Search Results
Results 251 - 300 of 1724
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Chrisoulidou Alexandra - - 2008
Ectopic production of CRH by a medullary thyroid carcinoma or its metastases is a rare cause of ectopic Cushing's syndrome (ECS). We report a 45-year old male with medullary thyroid carcinoma (MTC), who, 24 years following the initial diagnosis, presented with clinical and biochemical evidence of an ACTH dependent Cushing's ...
Gough Jenny - - 2008
BACKGROUND: Palpable thyroid nodules are present in 4-7% of the population and their prevalence increases with age. Thyroid incidentalomas-impalpable nodules detected fortuitously during a radiological investigation-may be found in up to 50% of patients. Although numerous guidelines exist that indicate the appropriate management of palpable thyroid nodules, there are no ...
Tacon Lyndal - - 2008
We describe a 31-year-old woman who had ingested minocycline for 18 months prior to presenting with hyperthyroidism and a palpable thyroid nodule. There was no evidence of Graves' disease or autonomous nodule on thyroid scintigraphy, and a clinical diagnosis of thyroiditis was made. Fine-needle aspiration biopsy of the palpable lesion ...
Agarwal Shweta - - 2008
In April 2006, a 55-year-old female presented with a thyroid mass and multiple skin nodules on scalp, forehead and neck. Fine needle aspiration cytology of thyroid mass and multiple skin nodules show tumor cells clusters in a repetitive microfollicular pattern on May-Grunwald-Giemsa stain suggestive of follicular thyroid carcinoma with metastasis ...
Yassa Leila - - 2008
BACKGROUND: A 25-year-old woman presented to her gynecologist with pelvic pain. Pelvic ultrasonography showed a 9 cm left ovarian mass. The patient underwent left oophorectomy, omental biopsy, and lymph node sampling. The ovarian mass proved to be a struma ovarii with numerous microscopic foci of papillary thyroid carcinoma. The patient ...
Ito Yasuhiro - - 2008
Among thyroid nodules arising from follicular cells, benign nodular goiter is thought not to metastasize to regional or distant organs. However, we encountered five cases that were pathologically diagnosed as benign nodular goiter but showed metastasis. The prevalence of benign nodular goiter showing metastasis was 0.17% (5 of 2978 patients). ...
Rydlova Marie - - 2008
AIMS: The differential diagnosis of thyroid nodules in routine practice can be problemmatic for both pathologists and clinicians. Effective treatment requires a determination of the biological nature of the lesions. For this reason, ancilliary diagnostic markers along with histological examination of the nodules may be useful. The objective of this ...
Baloch Zubair W - - 2008
The National Cancer Institute (NCI) sponsored the NCI Thyroid Fine-needle Aspiration (FNA) State of the Science Conference on October 22-23, 2007 in Bethesda, MD. The two-day meeting was accompanied by a permanent informational website and several on-line discussion periods between May 1 and December 15, 2007 (http://thyroidfna.cancer.gov). This document summarizes ...
Bryson Paul C - - 2008
OBJECTIVES: To use immunohistochemical (IHC) evaluation of proteins encoded by genes that were differentially expressed in follicular thyroid adenomas (FAs) vs follicular thyroid carcinomas (FTCs) to distinguish benign vs malignant follicular thyroid lesions. Multiple gene microarray studies suggest that benign and malignant follicular thyroid neoplasms have different gene expression profiles. ...
Prasad Nijaguna B NB Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, - - 2008
Although fine-needle aspiration biopsy is the most useful diagnostic tool in evaluating a thyroid nodule, preoperative diagnosis of thyroid nodules is frequently imprecise, with up to 30% of fine-needle aspiration biopsy cytology samples reported as "suspicious" or "indeterminate." Therefore, other adjuncts, such as molecular-based diagnostic approaches are needed in the ...
Erbil Yesim - - 2008
HYPOTHESIS: The detection of suspected malignant thyroid nodules by ultrasonography is associated with thyroid gland volume and tumor size. DESIGN: Prospective clinical trial. SETTING: A tertiary referral center. PATIENTS: Three hundred sixty-five patients with a multinodular goiter with coexistent dominant nodules. MAIN OUTCOME MEASURES: The correlation between thyroid gland volume ...
Gurunathan Ramesh Kumar - - 2008
This prospective study analyzed the factors that could predict thyroid gland involvement in patients suffering from malignancy of the larynx and laryngopharynx. Fifty patients underwent total laryngectomy with either ipsilateral hemithyroidectomy or total thyroidectomy in cases with subglottic extent more than 1.5 cm or in patients undergoing total laryngopharyngectomy for ...
Bartolazzi Armando A Department of Pathology, St Andrea University Hospital, Rome, Italy. - - 2008
In the USA, about 30 200 well-differentiated thyroid carcinomas were diagnosed in 2007, but the prevalence of thyroid nodules is much higher (about 5% of the adult population). Unfortunately, the preoperative characterisation of follicular thyroid nodules is still a challenge, and many benign lesions, which remain indeterminate after fine-needle aspiration ...
Dimosthenous Kypros - - 2009
This is a report of an angiolipoma of the thyroid gland, an extremely rare entity. A thorough search of the literature revealed only one previously reported example. The patient was a 77-year-old woman with a history of a nodular lesion of the thyroid in the context of a multinodular goiter. ...
Costache M - - 2008
AIMS: It is often difficult to differentiate between cases of desmoplastic trichoepithelioma (DTE) and morphoeic basal cell carcinoma (MBCC) because both lesions have many features in common. The aim was to clarify which criteria for differentiation offer the best basis for diagnosis. METHODS AND RESULTS: Nineteen cases of DTE were ...
Hor Tiffany - - 2008
Fine-needle aspiration of the thyroid gland is a common procedure that is increasingly being used to evaluate thyroid nodules incidentally found by other imaging means such as computed tomography scans. Rare complications include hematoma, transient vocal cord paralysis, seeding of carcinoma cells, and infection. Of these, hematoma is the most ...
Feisal T K - - 2008
An ectopic location of the thyroid gland usually occurs in the midline, starting anywhere from the tongue to the diaphragm. The occurrence of an ectopic thyroid gland in a non-midline site is extremely rare. We report a 32-year-old Malay woman with an aberrant thyroid gland presenting as a parapharyngeal lesion. ...
Wiseman Sam M - - 2008
The aim of this study was to evaluate the diagnostic and prognostic utility of the type 1 growth factor receptor family in the management of differentiated thyroid cancer (DTC). Tissue microarrays consisting of 100 benign thyroid lesions and 105 malignant thyroid lesions stained for HER1, HER2, HER3, and HER4 were ...
Dilek Fatma Husniye - - 2008
pl30cas is a multifunctional protein that is involved in many aspects of cellular physiology, including adhesion, migration, and regulation of the cell cycle, and can be regulated by a variety of stimuli. We immunnohistochemically examined pl30cas, cytokeratin 19 (CK19), and epithelial membrane antigen (EMA) expression in 37 cases of papillary ...
Weber Dana - - 2008
OBJECTIVE: Atypical epithelial cells, cannot exclude papillary thyroid carcinoma (AEC-PTC), in fine needle aspiration (FNA) of the thyroid is a controversial diagnostic category that might cause a dilemma in patient management. STUDY DESIGN: Eighty-eight thyroid FNA specimens from 86 patients with a diagnosis of AEC-PTC were retrieved from our files ...
Galofré Juan C - - 2008
Thyroid nodules are inexplicably frequent and affect approximately one-third of the adult population. The appropriate clinical management is focused primarily on excluding thyroid cancer and also on evaluating thyroid dysfunction and mechanical obstruction. There remains no evidence that a benign thyroid nodule, once diagnosed appropriately, will progress to a malignant ...
Yildirim Gokcen G Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, - - 2008
Simultaneous malignancies in the field of radiation for Hodgkin's disease is an extremely rare event. A unique case of concurrent thyroid and neck mass in the postirradiation field of a young patient with Hodgkin's disease is presented. Thyroidectomy and excision biopsy of the neck mass were performed. A 1.5-cm papillary ...
Schmitz K J - - 2008
Wegener's granulomatosis (WG) is a systemic vasculitis characterised by the presence of necrotizing granulomas and classically manifests as a triad of upper and lower respiratory tract involvement along with glomerulonephritis. Other rather unusual presentations of WG include ocular, salivary gland, cutaneous, gastrointestinal and cardiac involvement. We report a case in ...
Paramo Juan C - - 2008
OBJECTIVE: To identify clinical predictors of malignancy in patients with intraoperative frozen-section diagnosis of follicular neoplasm of the thyroid. METHODS: We performed a retrospective cross-sectional study of 71 patients with intraoperative frozen-section diagnosis of follicular neoplasm who underwent thyroidectomy between January 1992 and December 2000. Age, sex, tumor size, and ...
Berni Canani Francesco - - 2008
OBJECTIVE: To describe a case of thyroglossal duct cyst carcinoma that arose in a patient with right thyroid lobe hemiagenesis. METHODS: We present the imaging, physical examination findings, treatment, and clinical course of the study patient. RESULTS: A 35-year-old woman was evaluated for a neck mass that had been present ...
Ersoz Safak - - 2008
The aim of this study is to evaluate the significance of immunohistochemical expression of Galectin-3 in the differential diagnosis of benign and malignant thyroid nodules. We studied the fine needle aspiration specimens of 38 patients who had evaluated for nodular goiter and undergone a thyroid surgery between 2004-2005. Slides had ...
Piragua Sandra C - - 2008
In this article, a case of cystic struma ovarii with macrocystic change is presented. Cysts derived from struma ovarii may mimic a mucinous or serous cystadenoma. A careful examination for any thyroid microfollicles within fibrous septa or areas of solid stroma is key. In problematic cases, immunohistochemical staining with thyroglobulin ...
Faquin William C - - 2008
Nodules of the thyroid gland are frequently encountered, occurring in up to 7% of the population, and although most of these nodules are benign, carcinomas of the thyroid gland are the most common malignancy of the endocrine system. Although the different types of thyroid carcinoma are few, a wide variety ...
Than T H - - 2008
INTRODUCTION: It has been suggested that Galectin-3 (Gal-3) and Galectin-7 (Gal-7) are potential tumour markers for differentiating thyroid carcinoma from its benign counter part. Galectins are beta-galactoside-binding proteins with Gal-3 being a redundant pre-mRNA splicing factor. They are supposed to be p53-related regulators in cell growth and apoptosis, being either ...
Kim Hun-Soo - - 2008
Adenolipomas are rare benign neoplasms composed of mature adipose tissue and thyroid follicles. The preoperative fine-needle aspiration cytology of such lesion has rarely been cited. Approximately 12 cases have been reported in the literature worldwide, diagnosed solely on histopathology. A 65-year-old woman presented with a 4-month history of a thyroid ...
Gosnell Jessica E - - 2008
OBJECTIVE: To report the uncommon case of a woman with abdominal pain and a complex adnexal mass, who was subsequently found to have medullary thyroid carcinoma (MTC) metastatic to the ovary. METHODS: We present the clinical history, physical findings, laboratory and imaging studies, and pathologic findings in a woman with ...
Owens Christopher L - - 2008
To assess the utility of chemical analysis for parathyroid hormone in the rinse (PTH-r) obtained via fine-needle aspiration (FNA) in the setting of inadvertently sampled parathyroid tissue or lesions (PTL) during "thyroid" or "neck" FNA, the authors review their experience at a large, tertiary care academic medical center. All cases ...
Lollar Kevin - - 2008
OBJECTIVES: A case is reported in which Langerhans cell histiocytosis was found in the thyroid gland. Although the thyroid gland is frequently affected with multiple common diseases, a search of the English language literature suggests that Langerhans cell histiocytosis in the thyroid gland is rarely reported. STUDY DESIGN: The study ...
Talwar N - - 2008
Lingual thyroid is a rare developmental anomaly. It is the result of failure of the thyroid to descend from the foramen caecum to its prelaryngeal site. Lithium is a known goitrogen, but has never been reported to cause symptomatic enlargement of the lingual thyroid. We describe a 40-year-old woman, who ...
Liu Ying Y - - 2008
OBJECTIVES: The microscopic distinction between benign and malignant thyroid lesions in clinical practice is still largely based on conventional histology. This study was performed to evaluate the diagnostic value of galectin-3 (Gal-3), Hector Battifora mesothelial-1 (HBME-1), cytokeratin (CK)-19, CBP P300-interacting transactivator with glutamic acid E- and aspartic acid D-rich C-terminal ...
Wineland Andre - - 2008
OBJECTIVE: To describe an elusive case of blastomycosis involving the thyroid gland, which was ultimately diagnosed by use of ultrasound-guided fine-needle aspiration (FNA). METHODS: We present a case report, including clinical features, results of laboratory studies, and radiographic, computed tomographic, and ultrasonographic findings. In addition, the treatment and the utility ...
Basu Adhish - - 2008
BACKGROUND: Fine needle aspiration biopsy (FNAB) of the thyroid is a simple and safe investigation. Dissemination of malignant cells during FNA for papillary thyroid carcinoma is extremely uncommon. CASE: We report a 49-year-old woman who presented with a multicystic goiter and palpable cervical lymph nodes. Three sessions of FNAB (a ...
Aiad Hayam A - - 2008
BACKGROUND: Galectin-3 is a human lectin linked to malignant transformation in different organs including thyroid gland. We aimed to evaluate the diagnostic role of galectin-3 in differentiating benign from malignant thyroid lesions in cytological and histological samples. MATERIAL AND METHODS: This study included a total of 79 cases; 19 multinodular ...
Fischer Sandra - - 2008
CONTEXT: Thyroid lesions with nodular architecture and follicular pattern of growth often pose difficulties in accurate diagnosis during the assessment of cytologic and histologic specimens. The diagnosis of follicular neoplasm on cytology or of follicular tumor of uncertain malignant potential on histology is likely to cause confusion among clinicians and ...
Flanagan John N - - 2008
OBJECTIVE: To examine cytokeratin 19 (CK19) expression levels by immunostaining for protein and quantitative reverse-transcription polymerase chain reaction (qPCR) for messenger RNA in thyroid surgical specimens from patients with papillary carcinoma (PC) and other types of thyroid lesions. METHODS: A total of 54 randomly selected postoperative thyroid tissue samples were ...
Widder Sandy - - 2008
BACKGROUND: Histopathologic criterion for follicular variant of papillary thyroid cancer (FVPTC) has only recently been utilized universally. The purpose was to determine whether, on review, these criteria would result in a change in diagnosis of follicular neoplasm (FN). METHODS: A ten-year clinical cohort included patients with a diagnosis of a ...
Krause Kerstin - - 2008
BACKGROUND: With the advent of microarray technology, increasing numbers of marker genes are proposed to distinguish benign and malignant thyroid lesions. However, most markers await confirmation through independent studies. In this paper, we re-evaluate the diagnostic potential of 10 proposed candidate genes in benign and malignant thyroid pathologies in a ...
Ali, M A; ;
Thyroglossal cyst rarely presents with carcinoma formation in the remnants of the thyroid gland. We report a 40 year old male with papillary thyroid carcinoma formation in a thyroglossal cyst. The patient underwent surgical intervention for the cyst. His pathology was positive for thyroid carcinoma and he underwent complete thyroidectomy ...
El Demellawy Dina - - 2008
ABSTRACT: Papillary carcinoma of the thyroid (PTC) is the commonest thyroid cancer. In the recent decades an obvious increase in the incidence of PTC has occurred. The pathological diagnosis of PTC is usually an easy diagnosis in the majority of cases. However since the introduction of follicular variant of PTC ...
Mori Kiyoshi - - 2008
A 54-year-old man was admitted to the hospital presenting with a 3-month history of sclerosing dermal lesion in the external genitalia. A scrotal skin biopsy revealed a poorly-differentiated adenocarcinoma, immunohistochemically positive for cytokeratin 7 (CK7) and for thyroid transcription factor 1 (TTF-1), and negative for CK20. One month after admission, ...
Tom Andrea - - 2008
A 20-year-old Somali woman presented with a tender, enlarging neck mass in the setting of weight loss and tachycardia. This was initially thought to be a thyroid storm. On further investigation, she had suppurative thyroiditis from Mycobacterium tuberculosis. This case illustrates a high prevalence of extrapulmonary tuberculosis (TB) in foreign-born ...
Malloy Kelly M - - 2008
Most thyroid neoplasms arise from follicular cells and are well differentiated. Anaplastic and poorly differentiated carcinomas are rare and have a high mortality. Five percent of tumors are of C-cell origin, and 20% to 25% of these are hereditary. Thyroid lymphoma is rare and occurs in the setting of Hashimoto's ...
PaƟcanu Ionela - - 2008
Fine-needle aspiration biopsy (FNAB) of the thyroid, although not perfect, is considered currently the best preoperative method in establishing malignancy in a thyroid nodule. We report the case of an 8-year-old girl with a thyroid mass in the right thyroid lobe. Endocrine investigations revealed subclinical hypothyroidism and high titer of ...
Volante Marco - - 2008
Nodules having a non-follicular-non-papillary structure may be frequently encountered in the thyroid, the solid/trabecular arrangement being the most common feature. When solid/trabecular pattern is predominant within a thyroid nodule, the wide range of differential diagnoses represents one of the major diagnostic problems in the routine thyroid practice, including--among others--relatively frequent ...
Bucerius Jan - - 2008
Papillary carcinoma is the most common malignancy of the thyroid gland with initial lymphogenic metastatic spread in many cases. Hematogenous spread may affect the lung, bone and brain. We present a case of hematogenous metastases of papillary thyroid carcinoma both in the choroid and the skin, which are reported in ...
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