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An Jungsuk - - 2010
Primary schwannomas of the thyroid gland are extremely rare. These tumors most often present as asymptomatic solitary neck masses, slow growing and rarely malignant. Only 15 cases of intrathyroidal schwannoma have been reported in the literature, and few have been reported with fine needle aspiration (FNA) cytology. A 14-year-old male ...
Wo┼║niak Ewa - - 2010
Introduction: Recurrent goitre is a significant clinical problem among patients who have been operated due to benign lesions. An atypical localization of recurrent goitre - near the hyoid bone - poses additional difficulties as there are no data available on the clinical significance of such lesions. The aim of this ...
Listewnik Maria H - - 2010
Introduction: Radioiodine treatment (RT) of benign thyroid diseases is a well-known, safe, and effective treatment. In a group of patients after RT, who remained in long-term follow-up, sporadic cases of malignant thyroid lesions occurred. The aim of the study was to estimate how often it happened despite the exclusion of ...
Gutzeit Andreas - - 2011
Hemangioma of the thyroid gland is an extremely rare condition. We report a case of a primary cavernous hemangioma in the left lobe of the thyroid gland in an 84-year-old woman. Ultrasound examination of the lesion showed an inhomogeneous and hypoechoic nodule that was well demarcated from the rest of ...
Bishop Justin A - - 2011
Hyalinizing trabecular adenoma (HTA) is a rare primary thyroid neoplasm. Ever since its initial descriptions, controversy has surrounded the lesion, particularly in regard to its malignant potential and most appropriate terminology. HTA shares many features with medullary thyroid carcinoma and particularly papillary thyroid carcinoma, making it an especially treacherous lesion ...
Kim Eun Sook - - 2010
BACKGROUND: The association between autoimmune thyroiditis (AIT) and thyroid cancer is still not clear despite many previous reports. This study investigated whether serologic thyroid antibodies are predictive of thyroid cancer in patients with thyroid nodules. METHOD: We retrospectively reviewed records of patients with thyroid nodules evaluated by ultrasonography-guided fine-needle aspiration ...
Kagan Evgenia - - 2010
A patient with no immune compromise and no constitutional or pulmonary symptoms presented with an enlarging neck mass abutting the thyroid gland and extending through the pleura into the lung. Microbiologic evaluation revealed a diagnosis of cryptococcoma, and the patient responded well to oral fluconazole therapy. To the authors' knowledge, ...
Poiana Catalina - - 2010
We present a case of a Sertoli-Leydig cell tumour manifested with progressive hirsutism, frontal alopecia and secondary amenorrhea in a 46-years-old female, evolving for 6 years until presentation. Serum testosterone level was 8.01 ng/ml and gonadotropic hormones were LH 8.57 mIU/ml and FSH 9.52 mIU/ml. Computed tomography revealed a dense, ...
Wheeler Yurong Y - - 2010
Metastatic carcinomas to the thyroid are quite rare in daily cytology practice. However, when present they may produce a diagnostic dilemma, particularly when they share some morphologic similarities with primary thyroid lesions and when occurring in patients with occult malignant history. Herein, we report a case of metastatic gastric signet ...
Singaporewalla Reyaz M - - 2011
Ultrasound is routinely used in evaluating thyroid nodules and performing fine-needle aspiration cytology (FNAC). Occasionally, nonthyroidal lesions can mimic thyroid nodules on imaging and get wrongly aspirated. A 63-year-old woman was reported to have an incidental left thyroid "nodule" on neck ultrasound scan. It was isoechoic with a surrounding hypoechoic ...
Ozolins Arturs - - 2010
For management of thyroid nodules, distinction between benign and malignant tumours is essential. The study was performed to evaluate the diagnostic value of molecular markers in different thyroid tumours. Immunohistochemistry for CD56, HBME-1, COX-2, Ki-67, p53 and E-cadherin (E-CAD) was performed in 113 benign and 35 malignant thyroid lesions including ...
da Silveira Mitteldorf Cristina Aparecida Troques - - 2011
Thyroid nodules are a common clinical problem, and fine-needle aspiration biopsy (FNAB) is widely used for its evaluation. Only 5% are malignant, being papillary carcinoma (PC) the most frequent neoplasia. Approximately 20% are classified as indeterminate or suspicious for malignancy. Gene-expression pattern may be useful for diagnosing PC in difficult ...
Ekambaram Maheswari - - 2010
BACKGROUND: Hashimoto's thyroiditis (HT) is the most common cause of hypothyroidism in those areas of the world where iodine levels are sufficient. Fine-needle aspiration cytology (FNAC) can accurately diagnose this lesion in most of the patients. However, a small percentage of cases may be missed due to inherent limitations of ...
Suh Insoo - - 2010
BACKGROUND: Serum thyroglobulin (Tg) is the most accurate biomarker for thyroid cancer recurrence. However, some clinicians measure preoperative Tg as a diagnostic cancer marker despite lack of supporting evidence. We examined whether Tg accurately predicts malignancy in follicular or Hürthle-cell neoplasms. METHODS: We reviewed 366 patients who underwent thyroidectomies for ...
Chen Longwen - - 2010
BACKGROUND: The incidence of papillary thyroid carcinoma that has metastasized to the pancreas is extremely rare. To date, only 2 cases have been reported in the literature. CASE: A case of pancreatic metastatic papillary thyroid carcinoma occurred in an 82-year-old man with a prior history of thyroid papillary carcinoma, resected ...
Michalopoulos Nikolaos V - - 2010
A 78-year-old euthyroid patient presented for evaluation of a symptomatic, slowly growing neck mass. Ultrasound scan revealed a multinodular goiter and a hypoechoic nodule of the right thyroid lobe. Total thyroidectomy was performed and the lesion was completely excised. Definite diagnosis was obtained after histological examination of the surgical specimen. ...
Li Dong - - 2010
Iodine-131 (I-131) treatment and subsequent whole body iodine-131 scans (WBSs) are important in the management of differentiated thyroid carcinoma (DTC). Nevertheless, false positive benign lesions in WBS should be interpreted with reliable anatomic imaging methodologies to differentiate from true metastases. We report a DTC case with a concurrent thyroglossal duct ...
Pujani M - - 2010
Specific criteria are used to diagnose thyroid neoplasms; however, the distinction between certain neoplasms, such as follicular adenoma and carcinoma, could be difficult. Thus, additional diagnostic features that can assist in this distinction would have great clinical usefulness. To evaluate the role of the proliferative marker Ki-67 in nonneoplastic and ...
Lee Hwa-chan - - 2010
Cancer metastasis to the thyroid is extremely rare. The more commonly reported primary sites for metastasis to the thyroid are the kidney, breast, lung, colon, esophagus, and uterus. Thyroid metastasis from the stomach has only been reported in three cases. Herein, we report a 71-year-old man presenting with bilateral thyroid ...
Schinstine Malcolm - - 2010
Fine needle aspiration has become the most prominent, and the easiest way, to morphologically evaluate lesions of the thyroid. When done correctly, the sensitivity and specificity of thyroid aspirates for detecting malignancy is very high. Unfortunately, clinicians are sometimes confused by the terminology used in thyroid cytopathology reports. One way ...
Nuwal Paras - - 2010
We report an extremely rare case of primary adenoid cystic carcinoma (ACC) trachea presenting as midline swelling neck and mimicking thyroid tumor. A 44-year-old female presented with painless midline swelling neck without any respiratory complaints, hoarseness of voice or dysphagia etc. Fine needle aspiration cytology (FNAC) from swelling reveal features ...
Del Rio P - - 2011
Pre-operative cytology in thyroid disease remains the most appropriate diagnostic test for defining the nature of a thyroid nodule before surgical excision. We selected the most recent 825 surgical thyroid procedures performed in our institution from January 2004 to June 2007; 776 were total thyroidectomies, 23 were lobe-isthmectomies, and 26 ...
Kim D W - - 2010
There is no useful guide or study related to the differentiation of asymptomatic diffuse thyroid disease from normal thyroid by using thyroid US. This study was prospectively designed to evaluate the efficacy of the use of real-time thyroid sonography as performed by an experienced radiologist for the identification of asymptomatic ...
Joseph J - - 2011
Background National guidelines recommend that thyroid function is assessed at diagnosis of type I diabetes (TIDM) and annually thereafter. This paper reports an audit of thyroid surveillance in accordance with this guideline. Patients 110 patients (66 males), median age 11.3 (1.2-15.7) years at diagnosis of TIDM, were monitored for 2.3 ...
Kim Seung Ja - - 2010
BACKGROUND: Thyroid sonography is commonly used as a screening procedure resulting in finding of innumerable benign nodules. It would be necessary to apply strict sonographic criteria for incidentally detected thyroid nodules to avoid unnecessary invasive procedures or further examinations. PURPOSE: To prospectively evaluate the incidence of diverse thyroid lesions including ...
Ito Yasuhiro - - 2010
BACKGROUND: The recent prevalence of ultrasonography (US) has facilitated the early detection and qualitative evaluation of thyroid nodules. Furthermore, novel technical developments are extending the application range of US for other thyroid diseases. METHODS: The use of US to differentiate between thyroid carcinoma and benign nodule, between a metastatic lymph ...
Garcia Eduardo Anselmo - - 2010
Thyroid cancer is the most frequent endocrine neoplasia worldwide. The route for metastasis and loco-regional invasion preferentially occurs by lymphatic vessels. For this reason, the assessment of lymphatic vessel density (LVD) is supposed to represent both a prognostic parameter and also a potential therapeutic target. In order to evaluate the ...
Clerici T - - 2010
BACKGROUND: Follicular thyroid microcarcinomas (mFTCs) of 10 mm or less in size rarely manifest clinically and their clinical significance is controversial. This study assessed their characteristics and incidence, and analysed treatment modalities used for mFTC. METHODS: Members of the German Association of Endocrine Surgeons were asked to review patients with ...
Barut Figen - - 2010
Difficulties in diagnosis of thyroid lesions, even with histologic analysis, are well known. This study has been carried on to evaluate the role of immunohistochemical markers including galectin-3, Hector Battifora mesothelial cell-1 (HBME-1), and cytokeratin-19 in the diagnosis and differential diagnosis of benign and malignant thyroid lesions. The expressions of ...
Asioli Sofia - - 2010
Decoration of the nuclear membrane by emerin staining enhances detection of nuclear irregularities typical of papillary thyroid carcinoma (PTC). Our study aims to verify whether staining with emerin is a helpful diagnostic marker in fine-needle aspiration (FNA) cytology. We first designed a prospective study on smears, Thin Prep, and cell ...
Torregrossa Liborio - - 2010
BACKGROUND: The cytological discrimination between benign and malignant follicular-patterned lesions of the thyroid can represent a diagnostic challenge, even for experienced pathologists. We evaluated the diagnostic use of protein expression of CXC chemokine receptor 4 (CXCR4) and galectin-3 (gal-3) that were found to be upregulated in papillary thyroid carcinoma compared ...
Wallander Michelle - - 2010
Despite the recognition of the follicular variant of papillary carcinoma of the thyroid (FVPTC) for over 50 years, reproducibility of this diagnostic category has remained poor. Architectural features have been of variable utility as some FVPTC seem encapsulated, whereas others are multifocal and may be confused with nodular hyperplasia. Nuclear ...
Ardito Guglielmo - - 2010
BACKGROUND: The aim of this retrospective study was to assess the accuracy and usefulness of cytological classification of fine-needle aspirates in determining the appropriate surgical treatment for thyroid lesions studied with conventional smears (CS) and liquid-based cytology (LBC) in a split-sample method. PATIENTS AND METHODS: A total of 353 patients ...
Tan Winson J H - - 2010
INTRODUCTION: The aim of this study was to conduct an audit of the sensitivity and specificity of ultrasound, fi ne needle aspiration cytology (FNAC) and frozen section in the evaluation of thyroid malignancies in our practice. MATERIALS AND METHODS: The medical records of all the patients who underwent thyroid surgery ...
Turker Omer - - 2010
BACKGROUND: Posttherapy or diagnostic whole-body radioiodine (131I) scans are conducted to observe metastases of differentiated thyroid carcinomas. Sometimes, false-positive scans occur due a variety of lesions. Here we report a patient with marked radioiodine accumulation in a large adnexal cystadenofibroma, a benign ovarian tumor. SUMMARY: A 51-year-old woman underwent subtotal ...
Yoshino Yayoi - - 2010
A previously healthy 6-year-old boy had continuous fever for 6 days before admission to our hospital. His general condition was good except for pyrexia. The left lobe of the thyroid gland was swollen, red, hot, and tender, and neck movement was limited. The provisional diagnosis was upper respiratory tract infection. We ...
Michailidi Christina - - 2010
Focal Adhesion Kinase (FAK) and Src have been reported to regulate tumor growth, invasion, metastasis and angiogenesis. The present study aimed to evaluate by immunohistochemistry the clinical significance of FAK and Src expression in 108 patients with benign and malignant thyroid lesions. Total FAK expression provided a distinct discrimination between ...
Lee Sanghee - - 2010
The aim of this study was to evaluate whether sonography can diagnose medullary thyroid carcinoma (MTC) as a malignant lesion using widely accepted sonographic criteria and to compare which sonographic findings of MTC are different from findings for papillary thyroid carcinoma (PTC). The study included 42 patients (13 men and ...
Nemenqani Dalal - - 2010
The thyroid gland is a known but an unusual site for metastatic tumours from various primary sites. Primary smooth muscle tumours of thyroid are rare. Leiomyosarcoma of the thyroid gland whether of primary or metastatic origin should be distinguished from anaplastic carcinoma. Few cases of leiomyosarcoma metastatic to thyroid, diagnosed ...
Thakur Abhijit - - 2010
Ectopic cervical thymomas are often confused with thyroid or parathyroid swellings due to their anatomical positioning. Predominant epithelial thymoma can be misdiagnosed as papillary thyroid carcinoma on fine needle aspiration and lymph node metastasis of epithelial tumor on frozen section. Predominantly lymphocytic thymomas have often been misinterpreted as Hashimoto's thyroiditis ...
Sheth Sheila - - 2010
Ultrasonography (US) is the single-most valuable imaging modality in the evaluation of the thyroid gland. This review discusses the US appearances of thyroid nodules, emphasizing sonographic features associated with potentially malignant or, at the other end of the spectrum, likely benign nodules. Diffuse thyroid abnormalities have also been reviewed. The ...
O'Neill J P - - 2012
Struma Ovarii are mature teratomas. In rare circumstances thyroid tissue is found as part of the histopathological makeup. Malignant transformation may occur in 1-2% of these rare cases. To report a rare case of malignant thyroid carcinoma within a struma ovarii. A 22-year-old lady presented with a right pelvic mass. ...
Yeo S H - - 2011
SUMMARY: A 52-year-old man presented with subacute thyroiditis and showed an intensely hypermetabolic thyroid lesion on (18)F-FDG PET/CT. The patient also had coexisting chronic lymphocytic thyroiditis. The lesion of subacute thyroiditis revealed an SUV(max) of 9.1 g/mL and was ill-defined, heterogeneous, markedly hypoechoic, and hypovascular on US. Biopsy demonstrated histologic ...
Pang Tony - - 2010
BACKGROUND: Of all thyroid nodules assessed by fine needle aspiration cytology (FNAC), 10-20% are classified as indeterminate/atypical. Traditionally, this group is considered to primarily represent follicular neoplasia. We hypothesize that papillary carcinoma accounts for a significant proportion of lesions classified as "atypical" on FNAC. METHODS: This retrospective study includes 228 ...
Wang Y - - 2010
In this prospective study, the diagnostic value of real-time ultrasound elastography (USE) was evaluated in 51 consecutive patients referred for surgical treatment with single solid thyroid nodules < 10 mm in maximum diameter with an indeterminate result on B-mode and colour Doppler ultrasonography. Ultrasonographic results were compared with histopathological data. ...
Giaginis Constantinos - - 2010
Coxsackievirus and adenovirus receptor (CAR) expression on tumor cells is associated with sensitivity to adenoviral infection, being considered as a surrogate marker for monitoring and/or predicting adenovirus-mediated gene therapy. The aim of this study was to evaluate the clinical significance of CAR expression in human benign and malignant thyroid lesions. ...
Moslavac Sandra - - 2010
Thyroid fine needle aspiration cytology (FNAC) is the most accurate and cost effective method in the evaluation of the thyroid nodule and has been commonly used in adults. Thyroid nodules are uncommon in younger patients (1-2%). Our aim was to determine some relevant clinical and cytological parameters in this demographic ...
Iared Wagner - - 2010
OBJECTIVE: The purpose of this systematic review was to obtain summary estimates of the diagnostic accuracy of color Doppler ultrasonography (CDU) in predicting malignancy in thyroid follicular neoplasms (FNs). METHODS: We searched Medical Subject Headings together with the search terms "follicular," "thyroid," and "Doppler" in the MEDLINE, Web of Science, ...
Steinfort D P - - 2010
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has proven its utility in the mediastinal staging of lung cancer. Its use in the evaluation of thyroid lesions has not previously been described. We report the safe and effective use of EBUS-TBNA to evaluate a thyroid lesion in a patient with suspected lung ...
Fornelli Adele - - 2010
The first case of well-differentiated intrahepatic cholangiocarcinoma with remarkable follicular architecture resembling a follicular neoplasm of thyroid is described in a 52-year-old man. The follicles contained homogenous eosinophilic material akin to colloid and were lined by benign-looking cuboidal cells. Immunohistochemically, thyroid transcription factor-1 (TTF-1) and thyroglobulin were negative and the ...
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