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Hoenicke K - - 2004
Semicarbazide (SEM) is considered to be a characteristic protein-bound side-chain metabolite of the banned veterinary drug nitrofurazone. It is therefore used as a marker for nitrofurazone abuse. Recently, there has been concern about other sources of SEM in tissue samples, which are not linked to the illegal use of nitrofurazone. ...
Hurd H Scott - - 2004
The potential impact on human health from antibiotic-resistant bacteria selected by use of antibiotics in food animals has resulted in many reports and recommended actions. The U.S. Food and Drug Administration Center for Veterinary Medicine has issued Guidance Document 152, which advises veterinary drug sponsors of one potential process for ...
Klein Arnold W - - 2004
The forehead and crow's-feet (periorbital wrinkles) are among areas where Botox has been quite helpful. This cosmetic use is not approved by the Food and Drug Administration and is considered off-label. The effect, although temporary, is extremely popular with patients, has a very low incidence of side effects, and is ...
Ma Long-Sheng - - 2004
The first international comparison of femtosecond laser combs has been carried out at the International Bureau of Weights and Measures (BIPM). Three comb systems were involved: BIPM-C1 and BIPM-C2 from the BIPM and ECNU-C1 from the East China Normal University (ECNU). The agreement among the three combs was found to ...
Valenta Claudia - - 2004
Three different microemulsions (A-C) and one semisolid preparation D were investigated in terms of viscoelastic properties and skin permeation of the model compound sodium fluorescein. The influence of the polysaccharide carrageenan on these parameters was investigated. Carrageenan is frequently used as food additive and has very interesting properties like good ...
Willett Kristine L - - 2004
Botanical dietary supplements (herbal products) have flooded the market in the United States over the past decade, and studies show a significant percentage of Americans use them. With increasing frequency and duration of exposure, some serious adverse effects, though relatively uncommon, have been reported. Among the most troublesome is the ...
Aronson Sarah - - 2004
Escitalopram, a selective serotonin reuptake inhibitor (SSRI) was recently approved by the United States Food and Drug Administration (FDA) for the treatment of major depression. This chapter reviews preclinical and clinical studies with escitalopram, focusing on its therapeutic profile of action and tolerability. Escitalopram is the S-enantiomer of the racemic ...
Ortega Nathalie N Department of Anatomy, HSW1321, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0452, - - 2004
Endochondral ossification, the process by which most of the skeleton is formed, is a powerful system for studying various aspects of the biological response to degraded extracellular matrix (ECM). In addition, the dependence of endochondral ossification upon neovascularization and continuous ECM remodeling provides a good model for studying the role ...
Maeda Hiroaki - - 2004
Lactobacillus kefiranofaciens was reported to produce an exopolysaccharide named kefiran. In the present study, we developed a new medium, rice hydrolyzate (RH) medium, for the culture of L. kefiranofaciens. Structural analyses revealed that the exopolysaccharide produced by L. kefiranofaciens from RH medium was composed of a hexasaccharide repeating unit, and ...
Shave Evan - - 2004
In order to improve the production rates and lower the specific electrophoretic energy consumption values in preparative-scale, recirculating, binary isoelectric trapping separations, we propose to add an auxiliary isoelectric agent to the solution in the anodic separation compartment and another to the solution in the cathodic separation compartment to implement ...
McCabe Beverly J - - 2004
PURPOSE OF THE REVIEW: Adverse drug interactions may be the fourth leading cause of death in hospitalized patients. In children and older adults undetected food-drug interactions may lead to serious morbidity and mortality and be misdiagnosed as chronic disease progression. Recent recognition of the effects of certain foods on many ...
Takayanagui Osvaldo Massaiti - - 2004
Therapy for neurocysticercosis has advanced during the last 20 years with the advent of albendazole (Zentel) and praziquantel (Cysticide). Albendazole is the current medication of choice for the treatment of neurocysticercosis and is recommended for symptomatic patients with multiple viable cysts in the brain parenchyma. Albendazole may also be useful ...
Zhu Lihua - - 2004
The purpose of this research is to investigate the release of phenylpropanolamine from oxidized cellulose-phenylpropanolamine (OC-PPA) complexes prepared using aqueous OC dispersions (degree of neutralization, DN, 0-0.44) and phenylpropanolamine-hydrochloride (PPA.HCl) (concentration, 0.5 M or 1.4 M) in vitro and in vivo. The results showed a faster drug release from the ...
Cortes-Perez Naima G - - 2003
E7 oncoprotein of human papillomavirus-16 (HPV-16) is constitutively produced in cervical cancer (CxCa) and is a good candidate for the design of therapeutic vaccines. In this work, the nisin-controlled expression system was used to display the E7 protein at the cell surface of the food-grade Gram-positive bacterium Lactococcus lactis. An ...
Brasić James Robert - - 2003
Although the United States Food and Drug Administration banned its use for nocturnal leg cramps due to lack of safety and efficacy, quinine is widely available in beverages including tonic water and bitter lemon. Numerous anecdotal reports suggest that products containing quinine may produce neurological complications, including confusion, altered mental ...
Holtzheimer Paul E - - 2003
Mood stabilizers have evolved considerably over the past decade. Lithium, divalproex, and olanzapine are currently Food and Drug Administration-approved for the treatment of acute mania. A number of new and traditional medications have also been tested and are commonly used in clinical practice. Several strategies for managing treatment-resistant mania have ...
Farhat Walid - - 2003
The objectives of this study are to examine the porosity of bladder acellular matrix (ACM) using deionized (DI) water as the model fluid and dextran as the indicator macromolecule, and to correlate the porosity to the ACM thickness. Porcine urinary bladders from pigs weighing 20-50 kg were sequentially extracted in ...
Izaki Yoshinori - - 2003
We studied the interaction between paired-pulse facilitation (PPF) and long-term potentiation (LTP) in the hippocampo-prefrontal cortex (PFC, prelimbic area) pathway, stimulating the ventral or posterior dorsal CA1 region (vCA1 or pdCA1). In the vCA1-PFC, the group averaged PPF did not change after the LTP induction, and there was a negative ...
O'Neill Robert T - - 2003
This paper recounts contributions made by Sam Greenhouse to the Food and Drug Administration during his tenure as an advisory committee member and as chair of the committee. The events and topics are taken from available recollections and minutes and selectively describe a range of topic areas and issues about ...
Trieger Norman - - 2003
A product developed by researchers in Sweden (Biora AB Malmo, Sweden) has been approved by the United States Food and Drug Administration for use in the regeneration of periodontal attachment apparatus. Enamel matrix protein (Emdogain) has been shown to be effective in animal and human studies. This report documents a ...
Schumm Walter R - - 2003
Much of modern western law now presupposes opposition to discrimination based on race, religion, sex, national origin, and other factors. However, ancient religious Scriptures may have sanctioned certain types of discrimination. Whether those who are inclined to accept literal interpretations of their Scriptures will condone certain forms of discrimination could ...
Ohkimoto Kei - - 2003
Environmental estrogen-like chemicals are increasingly recognized as a potential hazardous factor for wildlife as well as humans. We have recently embarked on developing a zebrafish model for investigating the role of sulfonation in the metabolism and adverse functioning of environmental estrogens. Here, we report on a systematic investigation of the ...
Flamm W Gary - - 2003
Between 1970 and 1975 developments in environmental mutagenesis proceeded with amazing speed. These developments were both structural and conceptual in nature. A new infrastructure was built and new concepts about how best to protect consumers from exposures to mutagens emerged. The internal dynamics within the Food and Drug Administration played ...
Moore Brent A - - 2003
The current study provides an initial examination of lapse and relapse to marijuana use among 82 individuals who achieved at least 2 weeks of abstinence during outpatient treatment for marijuana dependence. Seventy-one percent used marijuana at least once (i.e., lapsed) within 6 months of initial abstinence, averaging 73 days (SD ...
Isoherranen Nina - - 2003
PURPOSE: Racemic valnoctamide (VCD) is a central nervous system-active drug commercially available in Europe. VCD possesses two chiral centers and, therefore, it exists as a mixture of four stereoisomers. The purpose of this study was to evaluate the anticonvulsant activity of two VCD stereoisomers in comparison with VCD (racemate), valpromide ...
Bishop Michael J - - 2003
Because of case reports of severe bronchospasm after the use of mivacurium, we used the Food and Drug Administration MedWatch database to determine the frequency of bronchospasm as an adverse event after the use of nondepolarizing muscle relaxants.
Noviasky John A - - 2003
Nesiritide is an effective agent for the treatment of decompensated CHF. However, the VMAC trial shows that the agent's efficacy and safety are actually more similar than dissimilar to those of nitroglycerin. Indeed, objective reviews have placed nesiritide as a second-line agent behind current standard drug therapy. Finally, nesiritide is ...
Brenner S - - 2003
Pemphigus is an autoimmune disease that results from the interaction between predisposing genetic factors and exogenous factors, the most common environmental factors being drugs and food. Topical phenol has induced pemphigus in one patient. Drugs and foods that induce pemphigus are divided into three main groups according to their chemical ...
Larkin Jennie E - - 2003
Arousal from deep hibernation is accompanied by a transient rise of melatonin (Mel) in circulation; there are no comparable analyses of Mel concentrations in species that undergo much shallower, shorter duration episodes of daily torpor. Serum Mel concentrations were determined during arousal from both natural daily torpor and torpor induced ...
Fauza Dario O - - 2003
Despite several, mostly isolated successes, few controlled, prospective trials have yet validated clinical tissue engineering applications. Although this may, at least in part, be explained by the very young age of this field, tissue engineering involves the need for an elaborate and expensive infrastructure, not to mention qualified personnel. This ...
Cozad Ann - - 2003
This article reviews published literature to determine the role environmental disinfection plays in the prevention of infectious disease. Health benefits from disinfection have been established through studies of applications such as critical instrument sterilization, water treatment, and food production. Guidelines by the Centers for Disease Control and Prevention, the Food ...
Touma Dany J - - 2003
Topical photodynamic therapy is an evolving relatively new modality in dermatology. While widely used in Europe for treatment of actinic keratoses and skin cancer, topical photodynamic therapy is still relatively unfamiliar in the United States. Approved by the US Food and Drug Administration in 1999, photodynamic therapy is now being ...
Fink-Bennett Darlene M - - 2003
Non-Hodgkin's lymphoma (NHL) is the most frequently diagnosed malignancy of the immune system, with more than 53,900 new cases diagnosed in 2002. Conventional cancer therapies cure many, but not the majority of, cases of the aggressive forms of NHL, and the more indolent and follicular forms of the disease that ...
Liang Yao-Yun - - 2003
MAD plays an important role in decapentaplegic (DPP) signaling throughout Drosophila development. Despite a recent study describing the restriction of DPP signaling via putative ubiquitin E3 ligase dSmurf (1), the molecular mechanisms of how dSmurf affects DPP signaling remain unexplored. Toward this goal we demonstrated the degradation of phosphorylated MAD ...
Richards John R - - 2003
Droperidol is an antipsychotic and antiemetic drug that has been used extensively by emergency physicians, psychiatrists, and anesthesiologists worldwide since 1967. It also has been used effectively for other diverse conditions, such as treatment of headache and vertigo. As of January 2001, Droperidol was no longer available in Europe after ...
Saylan Ziya - - 2003
A number of facial filler materials that have not yet been approved by the Food and Drug Administration for use in the United States have been employed by physicians in Europe for several years. Although these products have proved efficacious, some complications events have been associated with their injection or ...
Ashley-Morrow Rhoda - - 2003
BACKGROUND: HerpeSelect HSV-1 and HSV-2 ELISAs are glycoprotein G-based, type-specific antibody detection tests that are approved by the US Food and Drug Administration for diagnosis of genital herpes. GOAL: The goal was to determine seroconversion times by means of HerpeSelect ELISAs. STUDY DESIGN: Four-hundred thirteen sera from 113 patients with ...
Sloan Kenneth B - - 2003
PURPOSE: To determine whether the fluxes through hairless mouse skin for three homologous series of prodrugs of 5-fluorouracil (5-FU, 1) and 6-mercaptopurine (6-MP, 2) from saturated aqueous suspensions show dependencies on aqueous (SAQ) and isopropyl myristate (SIPM) solubilities similar to those shown by the identical compounds delivered from IPM. METHODS: ...
Adam B D - - 2003
This paper offers a critique of patient-deficit models of adherence by examining the articulation of dosing schedules and food prohibitions with the structure of everyday lives. Interviews with 31 men and 4 women taking HAART show that doses associated with regular daily life events are most consistently taken, but many ...
Donoghue Dan J - - 2003
Antibiotics are used by the poultry industry to enhance the health and productivity of flocks. The use of antimicrobials is strictly regulated by the Food and Drug Administration (FDA) and the USDA to warrant their safety and efficacy. Prior to regulatory approval, the pharmacokinetics and tissue tolerances of an antimicrobial ...
Stege H - - 2003
The Danish Ministry of Food, Agriculture and Fisheries funds a monitoring system based on drug usage information collected at the herd level: VETSTAT. VETSTAT is constructed as a relational database and data originates from three sources: pharmacies, veterinarians and feed mills. All administration of drugs for use in animal production ...
Koob Thomas J - - 2003
Nordihydroguaiaretic acid (NDGA), an antioxidant with two functional ortho-catechols from the creosote bush, has been shown to increase the mechanical properties of synthetic collagen fibers, producing biologically based, biocompatible fibers with material properties in uniaxial tensile tests to failure that are comparable to those of native tendon (Koob and Hernandez, ...
Kamijo Yoshito - - 2003
A 42-year-old man attempted suicide by ingesting about 150 mL of a saponated cresol solution containing about 50% cresol. His serum aminotransferase concentrations were elevated, and a coagulopathy was present at the time of admission, 15 hours after ingestion. The hyperaminotransferasemia and coagulopathy worsened on the second day, but resolved ...
Rogers True L - - 2003
PURPOSE: The purpose of this work was to investigate spray-freezing into liquid (SFL) and atmospheric freeze-drying (ATMFD) as industrial processes for producing micronized SFL powders with enhanced aqueous dissolution. Micronized SFL powders dried by ATMFD were compared with vacuum freeze-dried SFL powders. METHOD: Danazol was formulated with polyvinyl alcohol (MW ...
Ruiz-Santaella J P - - 2003
Rice (Oryza sativa var.), is one of the most important crops worldwide, and is cultivated in the five continents since it adapts itself to all climatic conditions. The most important weeds that reduce the world rice yield are Echinochloa spp., annual gramineae, which, because of the selection pressure imposed on ...
Coughlin Michael T - - 2003
The recent Food and Drug Administration approval of drotrecogin alfa (activated) and the potential of several other new therapies may represent the beginning of a breakthrough in the management of critical illness in the intensive care unit. However, their use in clinical practice will likely be dependent on a rigorous ...
Scholey Jonathan M - - 2003
It has been a decade since a novel form of microtubule (MT)-based motility, i.e., intraflagellar transport (IFT), was discovered in Chlamydomonas flagella. Subsequent research has supported the hypothesis that IFT is required for the assembly and maintenance of all cilia and flagella and that its underlying mechanism involves the transport ...
Narayana A - - 2003
Man has been fascinated by nature since he evolved from his primitive ancestors, the apes. No doubt to start with, he hunted for food mainly by killing the wild animals, but if there was anything on which he could depend upon with any confidence towards its availability, it was the ...
Carter David O - - 2003
Forensic archaeologists and criminal investigators employ many different techniques for the location, recovery, and analysis of clandestine graves. Many of these techniques are based upon the premise that a grave is an anomaly and therefore differs physically, biologically, or chemically from its surroundings. The work reviewed in this communication demonstrates ...
Killian Jessica - - 2003
The pubertal initiation of spermatogenesis is reliant on androgens, and during this time, 5alpha-reduced androgens such as dihydrotestosterone (DHT) are the predominant androgens in the testis. Two 5alpha-reductase (5alphaR) isoenzymes (5alphaR1 and 5alphaR2) have been identified, which catalyze the conversion of testosterone to the more potent androgen DHT. The present ...
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