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Hendeles L L College of Pharmacy, University of Florida, Gainesville - - 1990
Pancreatic enzyme products are formulated, manufactured, and sold without submitting efficacy or bioavailability data to the Food and Drug Administration because of a quirk in the law. We documented therapeutic failures in three patients with cystic fibrosis after pharmacists substituted generic pancrelipase capsules for the Pancrease brand. Gastrointestinal symptoms and ...
Antia N H - - 1990
The anaesthetic foot in leprosy poses the most major problem in the rehabilitation of its patients. Various attempts have been made to produce protective footwear such as the microcellular rubber-car-tyre sandals. Unfortunately these attempts have had little success on a large scale because of the inability to produce them in ...
Letko G - - 1990
The survival of isolated pancreatic acinar cells and of hepatocytes from rats was compared to mimic cell injury and death during the pathogenesis of acute pancreatitis in the presence of varying concentrations of trypsin, chymotrypsin and of the uncoupler 2.4-dinitrophenol (DNP). While hepatocytes were quickly damaged by trypsin they still ...
McNamara R K - - 1990
The "security hypothesis" suggests food hoarding by rats serves to preempt attack and therefore might be motivated by "anxiety". The "object value" hypothesis suggests rats hoard objects that they perceive as valuable as related to some state or need. These hypotheses were evaluated with the anxiolytic drug diazepam, which is ...
Avogaro A - - 1990
Isotope dilution studies of ketone body (KB) turnover have usually been performed using a single 14C tracer and the so called 'combined KB specific activity'. By definition, this approach does not allow to evaluate the individual kinetics of acetoacetate (AcAc) and 3-hydroxybutyrate (R-BHB) which is feasible only using the separate ...
Da Prada M - - 1990
A novel class of antidepressants is emerging with considerable therapeutic potential: reversible inhibitors of monoamine oxidase type A (RIMA). Moclobemide (Aurorix) is a representative RIMA. It is a fully and rapidly reversible inhibitor of MAO-A with a correspondingly intermediate duration of action in vivo. It is free of hepatotoxicity and ...
Krupka L R - - 1990
The number and content of tobacco advertisements were examined in seventy-four gender-oriented popular magazines published during the summer of 1988. More ads were present in women's than men's magazines, and the messages contained in these ads were differentially stressed as a function of the magazine's primary readership. The type of ...
Keeler R F - - 1989
Logistic and biologic aspects of three separate means of administration of cyclopamine for experimental induction of terata or embryonic death in sheep were examined. Oral capsule administration of crystalline cyclopamine is logistically simple and biologically effective, but costly in terms of amount of compound required. Embryos were affected in five ...
Cohen N - - 1989
Evaluation of a series of 3,4-dihydro-2H-1-benzopyran-2-carboxylic acids linked to the 2-hydroxyacetophenone pharmacophore present in the standard peptidoleukotriene antogonist FPL 55712 (1) has led to the discovery of Ro 23-3544 (7), an antagonist possessing greater potency and duration of action vs LTD4 than the standard (aerosol route of administration, guinea pig ...
Tipton M J - - 1989
The protection provided against the initial responses to cold water immersion by a partial coverage wet suit was assessed. Eighteen subjects performed three 2-min immersions into water at 5 degrees C. During each immersion, the subjects wore either: a) cotton overall, b) trunk and arms "wet" immersion suit, or c) ...
Bradner W T - - 1989
Over 600 analogues of mitomycin C (MMC) have been made in the past and more recently a number of Mitomycin A (MMA) derivatives have been prepared. Since many of the MMA type had the same organic side chain at the 7-position as previously prepared MMC analogues it was of interest ...
Padmaja G - - 1989
Since cassava (Manihot esculenta Crantz) is a staple food item of several million people in the tropics, its toxicity cannot be underestimated. Therefore an attempt has been made to understand the metabolic changes caused by the chronic administration of sublethal doses linamarin, the principal cyanoglucoside of cassava, to rabbits. A ...
Finney J - - 1989
Hematuria is an important sign that indicates the presence of a pathologic condition in the genitourinary tract. Causes can be categorized by where in the urinary tract the problem is located--above the kidney, in the kidney or one of its structures, or below the kidney. Another category is false hematuria, ...
Kyroudis A - - 1989
The effect of food on the movement of pellets in the gastro-intestinal tract was investigated in seven volunteers, either by means of X-rays taken after oral administration of barium sulfate pellets or by means of saliva concentration profiles of lithium obtained after oral administration of lithium sulfate controlled-release pellets. The ...
Yutrzenka G J - - 1989
A drug-adulterated food (DAF) method was used in an attempt to establish physical dependence on either pentobarbital or phenobarbital in male CF1 mice. The mice were acclimated to the control diet for four days and then assigned to treatment groups. Group I continued to receive the control diet; Group II ...
Foltin R W - - 1989
Food intake of six adult male baboons (Papio c. anubis) was monitored during daily experimental sessions lasting 22 hr. Food was available under a chain schedule with two-components. After completion of the first "procurement component" response requirement, access to food, i.e., a meal, became available under the second "consumption component" ...
Jue T - - 1989
Optimizing the surface-coil design and spectral-acquisition parameters has lead to the observation of the 13C NMR natural abundance glycogen signal in man at 2.1 T. Both the human muscle and hepatic glycogen signals can be detected definitively with a time resolution of approximately equal to 13 min. A 1H/13C concentric ...
Wessels I F - - 1989
Cyanoacrylate tissue adhesive (CTA) is very useful for emergency treatment of corneal perforations. Lack of Food and Drug Administration approval as well as concerns about toxicity from the application of large amounts of glue, however, have limited its use. It is difficult to apply a sufficiently small amount of glue ...
Borutaite V - - 1989
The aim of this investigation was to study the effect of intramitochondrial acyl-CoA on the respiration of rabbit heart mitochondria over the whole range of stationary respiratory rates between States 4 and 3. The creatine phosphokinase system was used for stabilization of extramitochondrial adenine nucleotide concentration. It was shown that ...
Brindley C J - - 1989
Following oral administration of acitretin with food, peak plasma concentrations of unchanged drug (Ro 10-1670) are reached within 4 h. The mean absolute bioavailability of acitretin is 59% with high interpatient variability consistent with that of etretinate. Taking acitretin with food results in an increased and more consistent bioavailability. The ...
Garcia-Rinaldi R - - 1989
Several techniques have been described for preparing and applying fibrin glue to control surgical bleeding. However, these methods tend to be cumbersome, expensive, or messy. Furthermore, commercial kits have not been approved by the Food and Drug Administration because of the potential risk of hepatitis contamination. Therefore, we have devised ...
Moch R W - - 1989
Recently, the Food and Drug Administration has received several petitions which raise the question of the significance of an increased number of treated rats with foci of hepatocellular alteration. Study pathologists are responsible for defining the diagnostic criteria used in any study to diagnose proliferative changes in the liver. Similarly, ...
Stoeckel K - - 1989
Cefetamet pivoxil belongs to the class of orally absorbed pro-drug esters which are hydrolyzed to the active compound (cefetamet) on their first pass through the gut wall and/or the liver. The intravenously administered cefetamet is eliminated predominantly unchanged in the urine by glomerular filtration. Systemic and renal clearance values for ...
Roth S H - - 1989
Non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy is a serious public health problem. The United States Food and Drug Administration has recently proposed strong class labelling for NSAIDS, warning of the risk of ulceration, bleeding and perforation associated with their use. The adaptation of the gastric mucosa in response to NSAID intake ...
Takahashi J - - 1988
Twenty experimental phosphate-bonded investments were prepared by the mixing of two types of fillers (spherical glass beads and irregularly shaped silica particles) with five types of filler aggregates of different porosities, and two different ratios of MgO to NH4H2PO4. These investments were mixed with three different liquids, and their setting ...
Villa P - - 1988
Rat hepatocytes were used to study the toxicity of a new semisynthetic macrolide, roxithromycin, in comparison with erythromycin base and erythromycin estolate. Roxithromycin caused lactate dehydrogenase leakage close to that of erythromycin estolate and higher than erythromycin base after 21 h of exposure to the drugs. This effect was, at ...
Gill K - - 1988
Previous work with the serotonin uptake blocker, sertraline, demonstrated that the drug suppressed the consumption of ethanol and saccharin as well as body weight gain. There is increasing evidence that many serotonergic agents such as agonists, releasing agents and uptake blockers, reduce food intake. Sertraline was found to have a ...
Lijnen P - - 1988
The effect of xipamide on the intracellular concentration and transmembrane fluxes of Na+ and K+ was studied in 12 normal male subjects, using a double-blind cross-over design. After a run-in period on placebo for 1 week, the subjects were treated with either placebo (n = 6) or xipamide 20 mg ...
Lukas S E - - 1988
Single daily subcutaneous injections of buprenorphine (1.0 mg/kg), diprenorphine (1.0 mg/kg), or heroin (1.0 mg/kg) were given over 25 consecutive days to examine the degree and the rate of tolerance development to drug-induced suppression of food maintained responding. One gram food pellets were available on a second order schedule (FR ...
Desai K M - - 1988
The diagnosis of venous leakage as a cause of impotence, based on failure to induce an artificial erection by means of rapid saline infusion alone, may be invalid. Our recent experience with 2 men whose impotence was subsequently found to be psychogenic in nature suggests that saline erection cavernosometry should ...
Moore G L - - 1988
A red cell additive solution (AS-005) containing ascorbate-2-phosphate (AsP) to maintain 2,3-diphosphoglycerate, plus adenine, phosphate, and mannitol to retain viability and reduce hemolysis, was evaluated by human clinical trials. A crossover design was used with another additive solution (Nutricel AS-3, Cutter Laboratories) serving as the control for each donor. Each ...
Mangino M J - - 1988
The effects of thromboxane synthesis inhibitors (imidazole and U 63557A; Upjohn) and the cyclooxygenase inhibitor, mefenamic acid, on jejunal capillary filtration coefficients (Kfc) were determined in dogs before and during the presence of predigested food in the jejunal lumen. The jejunal Kfc increased significantly soon after the placement of a ...
Sattler J - - 1988
In a randomized controlled trial, 30 pigs were orally treated with histamine (60 mg). In addition, half of the animals underwent a specific blockade of the enzyme diamine oxidase (DAO), which is the main histamine catabolising enzyme in the intestinal tract. Only these DAO-blocked animals exhibited severe clinical symptoms (e.g. ...
Serene T P - - 1988
Samples of four brands of gutta-percha and the nine ingredients that make up one brand were studied in vitro to observe their interaction with the serum complement system, thus allowing for assessment of their possible inflammatory potential. Crossed immunoelectrophoresis of the third complement component was used as an indicator of ...
Wu L J - - 1988
The ultrastructural changes caused by a new antimalarial drug, pyronaridine, were investigated using mice infected with erythrocytic forms of Plasmodium berghei and P. falciparum cultivated in vitro in human erythrocytes. The first changes observed in both parasites after exposure to pyronaridine occurred in the food vacuoles. This suggests that the ...
Franzén L - - 1988
Three different means of diminishing discomfort during radiation therapy of the gastrointestinal tract are demonstrated and discussed: 1. Use of the smallest possible treatment volumes in medically well developed regions with good possibilities for follow-up of all patients. 2. Regular consultations, with advice concerning food intake and dental hygiene 3. ...
Oser B L - - 1987
A review of the history of the evolution of the science of toxicology from the original concepts of Paracelsus through the early development of analytical chemistry and its contributions to the detection of toxic substances in foods and drugs as these have led to modern regulatory rules for public protection ...
Stroup W H - - 1987
The precision of instruments used in 3 collaborative studies conducted within the Food and Drug Administration over a 4-year period (1981, 1982, 1984) for water activity (aw) determinations according to the official AOAC method is evaluated. Calibration responses of the instruments were tested for linearity over the aw range from ...
Gayle M E - - 1987
You, as individuals and as professionals, cannot be expected to solve all the problems of this decade and those projected for the future that I have discussed with you today, but you must accept the challenge to help bring individuals and society to a more holistic approach to a quality ...
Price V F - - 1987
Coadministration of caffeine (CAF) with acetaminophen (ACM) to mice prolonged the blood half-life of ACM, increased moderately the fraction of ACM excreted as the glucuronide conjugate, and decreased slightly the fraction excreted as the sulfate conjugate. CAF exerted more profound effects on fractions of ACM metabolites which are formed as ...
Hobara T - - 1987
In order to examine the cholecystohepatic circulation of trichloroethylene (TRI) and its metabolites, we injected the gallbladder with TRI and its metabolites, i.e. chloral hydrate (CH), free-trichloroethanol (F-TCE), trichloroacetic acid (TCA) and conjugated-trichloroethanol (Conj-TCE), using anesthetized dogs. The absorption rates of water from the gallbladder were 25-30% 2 h after ...
Kondo Y - - 1987
Using the in vitro microperfusion technique on isolated rat papillary collecting duct (PCD), we examined whether the glutaraldehyde-fixation method can be also applied to the mammalian collecting duct for preservation of the vasopressin-stimulated water and urea transport. Arginine vasopressin (AVP) at 10(-9) mol/l increased diffusional water permeability (Pdw) from 101.9 ...
Bartzokas C A - - 1987
The initial and cumulative efficacy of two antiseptic handwash preparations in eliminating Serratia marcescens from hands was evaluated on volunteers. Two antiseptics with persistent skin antibacterial activity, 4% chlorhexidine gluconate in detergent and 1.5% triclosan in natural soap, were studied in a new protocol designed according to Food and Drug ...
Hughes J R - - 1987
In a sample of 1,006 middle-aged male smokers drawn from the general population, 90% (N = 905) fulfilled DSM-III criteria and 36% (N = 362) fulfilled Fagerstrom's criteria for tobacco dependence. Among the 875 who had stopped smoking in the past for at least 24 hours, 21% (N = 184) ...
Edwards W T - - 1987
Mechanical studies of the Functional Spinal Unit (FSU) in-vitro have shown that the slopes of the load-displacement curves increase with load. This nonlinearity implies that the stiffness of the FSU is not constant over the range of physiologic loads, and that measurements obtained for FSU specimens through the application of ...
Asghar K - - 1987
A review of the literature indicates that a number of food constituents, e.g., dietary sugar, neurotransmitter amino acid precursors and food deprivation, may modulate the development of tolerance and physical dependence as well as influence the self-administration of several drugs of abuse in animals. In particular, the role of palatability ...
Schunack W - - 1987
The H2-receptor antagonists which are used for ulcer therapy fall into four main structural classes. Cimetidine is an imidazole derivative; ranitidine belongs to the basically substituted furans, famotidine is a member of the guanidinothiazole group; and roxatidine belongs to the aminoalkylphenoxy series. Famotidine is the most potent, selective H2-receptor antagonist ...
Sebel P S - - 1987
We have studied the transdermal absorption of tritiated fentanyl (citrate and base) and sufentanil citrate. Approximately 50 micrograms of drug in water was applied to the forearm skin of volunteers (5 subjects for fentanyl citrate and base, 6 for sufentanil). When the water had evaporated the site was covered with ...
Kan J P - - 1987
SR 95191 [3-(2-morpholino-ethyl-amino)-4-cyano-6-phenylpyridazine] is a novel psychotropic drug which possesses the pharmacological properties of a selective, reversible type A monoamine oxidase inhibitor (MAOI). The MAOI activity of SR 95191 was examined in the rat brain, liver and duodenum and compared to that of clorgyline, harmaline, l-deprenyl, moclobemide and cimoxatone. In ...
van Leeuwen F X - - 1987
Inorganic bromide is widely distributed in nature. Its natural physiological role in animal life is unknown. More than a century ago bromide was introduced in medicine as an antiepileptic drug. Nowadays, man is primarily exposed to bromide via food as the result of use of bromide-containing fumigants in intensive horticulture ...
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