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Results 451 - 500 of 712
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Schatz R A - - 1996
Interest in coronary stenting has exploded since the publication of several large, randomized trials, and (due to the rapidity of patient recruitment into non-randomized trials) volumes of data are quickly abandoning "old standards" of patient selection, operative technique, and postoperative anticoagulation management. In this editorial, suggestions are offered to help ...
Apfelberg D B - - 1996
Fifty-one patients underwent a study approved by the Food and Drug Administration for laser-assisted liposuction in five plastic surgery centers. The YAG laser fiber is contained within the cannula, shears off the fat cleanly, and coagulates blood vessels as the fat is drawn into the cannula. Hemoglobin decrease was relatively ...
Bristol D R - - 1996
The problem of establishing the equivalence of an experimental treatment to a control with respect to a binary ("success" or "failure") response variable may be solved using an approximate (1-alpha) 100% confidence interval for the difference in the response rates (i.e., success probabilities). If the goal is to show that ...
Payne A P - - 1996
The hamster Harderian gland seems to present both an excellent model for the control of porphyrin biosynthesis and an unusually robust example of the interrelationship between structure and function. It has been known for some time that 1) the capacity for manufacturing and storing porphyrins and 2) gland histology and ...
Meltzer R S - - 1996
The Food and Drug Administration has recently revised its guidelines regarding acoustic output on diagnostic ultrasound equipment to allow a new track for manufacturers to achieve approval to market diagnostic ultrasound equipment. It would move for the first time toward regulating instrumental output based on scientific bioeffect data. It would ...
Wirth S B - - 1996
Fibroblast growth factor-2 (FGF-2), locally administered in gelfoam to the striatum of mice treated with the neurotoxic drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), has restorative and neuroprotective effects on dopaminergic neurons and associated striatal transmitter systems. Most of the beneficial alterations are apparently indirect. FGF-2 must therefore act through a series of cellular ...
Oguro T - - 1996
The mechanism by which molybdate produces joint and bone deformities is not known. However, we recently reported that molybdate decreases the sulfation of acetaminophen in rat liver. Therefore, the purpose of the present study was to determine the effect of molybdate on the sulfation of glycosaminoglycans (GAGS) and whether manganese-induced ...
Woodland E D - - 1996
1,2,3-Benzotriazin-4-one derivatives are extensively used as herbicides, insecticides and nematicides. Incorporation of these compounds into the human food chain is a cause for concern, since their toxicity to man is well documented. This work describes the development of a data-base of classical 1,2,3-benzotriazin-4-one fragmentation patterns and consequent sequential neutral mass ...
Pallikaris I G - - 1996
Corneal topographic hardware was used to develop software analysis for configuration and localization of relaxing astigmatic arcuate incisions. The software is based on the assessment of the results of corneal topographic measurements, performed by the EyeSys Corneal Analysis System. Data assessment includes: A) plotting the dioptric power curves along the ...
Welling P G - - 1996
This chapter provides an update on drug-food interactions reported in the literature during the past five years. The number of studies examining this phenomenon has increased dramatically, and many of the results of these studies have been unpredictable and spectacular. Drug-food interactions should really be considered as formulation-food interactions because ...
Wiklund I - - 1996
Since Quality of Life is increasingly more often used as a therapeutic endpoint in clinical trials, it is essential that the same level of scientific rigour is applied to these assessments. The draft guidelines issued by the Food and Drug Administration as well as with the Common Market are therefore ...
Turner R M - - 1995
An 8-year-old stallion was evaluated because of recurrent urinary tract infections and chronic intermittent urospermia. After extensive diagnostic testing, it was hypothesized that the stallion had a reflex dyssynergia of the bladder and urethral sphincter. Initial attempts to manage the urospermia included semen fractionation, semen collection after voluntary urination, and ...
Wu S P - - 1995
The effects of chopsticks handle diameter and tip angle on the food-serving performance of pinching food, pulling food, shearing food and thrusting food, were investigated in this study. A total of 24 male subjects was tested using 12 pairs of experimental chopsticks, consisting of three types of different handle diameters ...
Garattini S - - 1995
The present status of knowledge on drugs affecting food intake and presumably acting via a serotoninergic mechanism is reviewed. The mechanism of action of these drugs is analyzed at the neurochemical level. All the drugs, to various extents, inhibit the uptake of serotonin (5HT), increase the release of 5HT and ...
Suzuki T - - 1995
The effects of nifedipine on the development of physical dependence on barbital and diazepam in rats were examined using the drug-admixed food method. Rats were chronically treated with either barbital- or barbital in combination with nifedipine-admixed food for 28 days, and with either diazepam- or diazepam in combination with nifedipine-admixed ...
Fowler S F - - 1995
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of torsemide are reviewed. Torsemide belongs to the pyridine-sulfonylurea class of loop diuretics. Its primary site of activity is the thick ascending limb of the loop of Henle, where it blocks active reabsorption of sodium and chloride, resulting in ...
Webb D D - - 1995
OBJECTIVE: This study examined the effect of administration with food on the ability of ranitidine bismuth citrate to suppress and eradicate Helicobacter pylori in 41 infected volunteers. RESULTS: After a 7-day course of treatment with ranitidine bismuth citrate (400 mg b.i.d.), 90% (18/20) of subjects who received the drug with ...
Andersson G - - 1995
The purpose of this investigation was to assess nicotine regulation among users of portion-bag Swedish oral moist snuff (snus) when switching from an ordinary snus product (Brand A) to a low-nicotine product having only half the concentration of nicotine (Brand B). Two studies were performed to compare the short-term effects ...
Glinsmann W H - - 1995
Carbohydrate sweeteners in the diet, which are sources of added sugars, have recently undergone changes that vary considerably among countries. The major driving force for these changes is a technological development that permits conversion of corn and other starches to sweeteners. Major changes in the type of sweeteners used in ...
Morita M - - 1995
Agelasphin-9b, (2S,3S,4R)-1-O-(alpha-D-galactopyranosyl)-16-methyl-2- [N-((R)-2- hydroxytetracosanoyl)-amino]- 1,3,4-heptadecanetriol, is a potent antitumor agent isolated from the marine sponge Agelas mauritianus. Various analogues of agelasphin-9b (a lead compound) were synthesized, and the relationship between their structures and biological activities was examined using several assay systems. From the results, KRN7000, (2S,3S,4R)-1-O-(alpha-D- galactopyranosyl)-2-(N-hexacosanoylamino)-1,3,4-octadecanetriol , was selected ...
McEvoy M - - 1995
Tuberculosis (TB) has been recorded in London for centuries but reports have declined over the last 100 years, with a 10-fold decrease between 1948 and 1987. However, from 1987-1993 notifications of TB in London rose by 34%, compared with 15% nationally. This rise, together with concerns about undernotification and the ...
Blaney C L - - 1995
Progestin-only pills (POPs) are less widely used and available than combined pills. For example, the U.S. Agency for International Development (USAID) shipped only 3 million packets of POPs worldwide in 1994, compared with 62 million packets of combined pills, according to Mark Rilling, program analyst with USAID's Office of Population. ...
Baczynskyj W M - - 1995
The U.S. Food and Drug Administration (FDA) conducted a survey of domestic and imported ceramic dinnerware from January to February 1992 to determine the status of lead leaching from this ware. Ceramicware was screened at the collection point by using the Quick Color Test (QCT); if the QCT was positive, ...
James G L - - 1995
BZA-5B, a benzodiazepine peptidomimetic, inhibits CAAX farnesyltransferase (FTase) and blocks attachment of farnesyl groups to oncogenic and wild-type H-Ras in animal cells. This compound slows the growth of cells transformed with oncogenic H-Ras at concentrations that do not affect the growth of nontransformed cells. This finding suggested that nontransformed cells ...
Ki F Y - - 1995
As a consequence of a hearing on bioequivalence conducted by the Food and Drug Administration in 1986, the identification and the treatment of a potential outlier in bioequivalence trials has become an important issue in the assessment of bioequivalence because the exclusion of a statistically identified outlier may lead to ...
Rosenthal P J - - 1995
The effects of peptide proteinase inhibitors on globin hydrolysis by cultured malaria parasites were studied. All of the four cysteine proteinase inhibitors evaluated blocked globin hydrolysis, as documented by the development of a morphological abnormality in which parasite food vacuoles filled with undegraded globin and by SDS-PAGE showing that the ...
Brown M B - - 1995
Hyaluronan is a glycosaminoglycan and has a protective, shock-absorbing and structure-stabilizing role in connective tissue. Recently, it has been suggested that hyaluronan can be used as a controlled and localized delivery vehicle for diclofenac in the treatment of a variety of conditions including osteoarthritic pain, basal cell carcinoma and actinic ...
Poiani G J - - 1994
Synthetic approaches for the preparation of macromolecular conjugates of the antifibrotic agent cis-4-hydroxy-L-proline (cHyp) were explored, and the efficacy of the conjugates in inhibiting collagen accumulation was investigated in vitro and in vivo. In one approach, poly(PEG-Lys), an alternating copolymer of poly(ethylene glycol) (PEG) and lysine, was used as the ...
Joshi B N - - 1994
Daily administration of melatonin for 8 weeks, either in the morning (9 a.m.) or late in the afternoon (5 p.m.), resulted in significant prolongation of the estrous cycle in the Indian desert gerbil Meriones hurrianae. The gonadosomatic index increased significantly (p < 0.01) in the melatonin-treated gerbils compared to the ...
Homeida M - - 1994
It has been suggested that praziquantel (40 mg/kg) and albendazole (400 mg) administered together may have a synergistic effect on intestinal parasites. In the present study, the pharmacokinetics of these agents, alone and in combination, were investigated in the presence and absence of food in two groups of Sudanese males. ...
Roebothan B V - - 1994
Dietary intakes and drug consumption were recorded for 24 seniors in a Newfoundland outport. Food frequency questionnaires suggested that the food groups consumed least adequately by the seniors were grain products and meat and alternatives: 71% did not consume the recommended daily minimum intake of grain products and 66.7% did ...
Hayden P J - - 1994
The biological properties of tumor-promoting and antipsoriatic 9-anthrones have been hypothesized to be mediated by free radical products such as the corresponding 9-anthron-10-yl radicals or by O2-, OH, and other persistent secondary radicals that are formed in the skin after topical treatment with 9-anthrones. To gain additional insights into the ...
Heck E L - - 1994
In this article we develop a calculation or formula for use in determining the potential dilution effect of fluids administered during patient treatment on serologic testing parameters. The formula uses basic principles of (a) fluid distribution over time from administration; (b) ratios of plasma and extravascular fluid volumes to body ...
Peeters J E - - 1994
Coccidia were isolated from 122 Belgian broiler farms without clinical coccidiosis. Shuttle programs including robenidin or nicarbazine in the starter (7-14 days) followed by an ionophore or diclazuril in the grower ration were most commonly used. Out of 215 coccidiosis-positive groups, 146 Eimeria acervulina, 65 E. maxima, and 88 E. ...
Komura J - - 1994
This study was conducted to investigate the effects associated with high dose administration of organic manganese to mice and to compare these effects with those of inorganic manganese. The disposition and toxicity of methylcyclopentadienyl manganese tricarbonyl (MMT; a potential substitute for lead in gasoline) in the brains of ddY mice ...
Prakash P - - 1994
Anteropositioning of inferior oblique is of late becoming popular but it inadvertently also entails a compulsory recession which may be undesirable at times. We have evaluated the effect of a 'pure' anteropositioning procedure (11 eyes), with Elliot & Nankin's anteropositioning (10 eyes) and Parks' recession (17 eyes). The mean change ...
Bagian J P - - 1994
Since March 1989, intramuscular (IM) promethazine has been successfully used to treat the symptoms of space motion sickness. The incidence of sedation associated with promethazine administration on the ground is large and may result in operational impact. The authors undertook a retrospective study to quantify the incidence of sedation from ...
Reyes-Chilpa R - - 1994
(-)-Edunol a prenylated pterocarpan was isolated from the roots of two Mexican 'snakeweeds', Brongniartia podalyrioides and B. intermedia (Leguminosae). Edunol (3.1 mg/kg, i.p.) reduced the expected mortality of mice previously treated by the same route with the LD50 of the venom of the serpent Bothrops atrox. The molecular structure and ...
Fujii T - - 1994
Both enantiomers [(1'R)-6 and (1'S)-6] of N6-(1,3-dimethyl-2-butenyl)adenine and their 9-beta-D-ribofuranosides [(1"R)-16 and (1"S)-16] have been synthesized for the first time from both enantiomers of alanine (15) in nine steps. These aglycones and nucleosides, together with N6-(3-methyl-2-butenyl)adenine (5) and its 9-beta-D-ribofuranoside (18) as well as 9-beta-D-ribofuranosyl-cis-zeatin (20) and 9-(2-deoxy-beta-D-ribofuranosyl)-cis-zeatin (19), were ...
Huang-Lee L L - - 1994
Previously we demonstrated that the contraction of collagen fibrillar matrices (CFM) by fibroblasts was significantly reduced when high concentrations (> 1 mg/ml) of hyaluronan were present in the media. This highlights the prominent role of hyaluronan in preventing scar formation during fetal wound healing. In the present study, we covalently ...
Jäger-Waldau R - - 1994
An account is given on the development of a purely mechanical Micro Spray Pump (MSP) which is capable of delivering aqueous drug solutions to the respiratory tract. In-vitro, deposition characteristics of two solutions, food dye and salbutamol sulphate, at different dosage levels and various flow rates were determined. A theoretical ...
Morotomi Y - - 1994
The aim of this study was to define the functional role of the pancreaticoduodenal papilla (PDP) in the regulation of pancreatic outflow into the duodenum in response to feeding and secretin administration in conscious dogs. The canine model we developed allowed for measurement of the pancreatic ductal pressure and pancreatic ...
Brenner S - - 1994
Today it is generally accepted that every drug that possesses an active thiol group in its molecule is capable of inducing pemphigus. Some plants, in particular those belonging to the Allium group, contain several active compounds with stable disulfide and thiol groups in their molecule. The Allium group contains many ...
Malsch R - - 1994
Unfractionated heparin and LMMH were substituted with different lipophilic organic compounds. Specifically endpoint attached (LMMH-tyramine and LMMH-tyramine-FITC) and nonspecifically substituted heparins (acylated heparins, and LMMH-biotin and LMMH-cholesterol hemisuccinate) were obtained. The lipophilically substituted heparins were analysed by HPSEC and showed different retention times, high peak purity, different UV/VIS absorbances, and ...
Dhanoa D S - - 1993
A series of N-acylated indoles (12-18), N-alkylated indoles (19-24), N-acylated dihydroindoles (26-30), and N-alkylated dihydroindoles (31-34) were synthesized and evaluated in the in vitro AT1 (rabbit aorta) and AT2 (rat midbrain) binding assay. The carboxylic acid 3-[[N-(2-carboxy-3,6-dichlorobenzoyl)-5-indolyl]methyl]-5,7-dimeth yl- 2-ethyl-3H-imidazo[4,5-b]pyridine (14b) was found to be the most potent AT1 (IC50 = ...
Bamforth K J - - 1993
Interactions between dietary xenobiotics, drugs and biologically active endogenous compounds are a potential source of idiosyncratic adverse pathology. We have examined the inhibition of the sulphation of a number of xenobiotics and endobiotics in human liver cytosol by 15 food additives and constituents. Sulphation of dehydroepiandrosterone was resistant to inhibition ...
Kousen M - - 1993
The nausea and vomiting that often accompany early pregnancy may be ameliorated if the patient eats small portions of food at frequent intervals, increases the amount of carbohydrates and decreases the amount of fat, and avoids bothersome food odors. When these strategies fail, antiemetic drugs such as pyridoxine and phosphorated ...
Hyman F N - - 1993
The Food and Drug Administration maintains a passive surveillance system for reporting and follow-up of complaints related to food items. The most commonly reported complaint is the discovery of foreign objects in food. The most common injuries are abrasions to the throat and buccal mucosa. Although dentists are qualified to ...
Maeno Y - - 1993
Ultrastructural changes induced in Plasmodium falciparum by artemisinin were studied in vitro. Electron microscopic autoradiography was performed on infected erythrocytes that were exposed in vitro to 3H-dihydroartemisinin and 14C-artemisinin. These drugs consistently were located in food vacuoles and mitochondria. Two hours after administration, changes were observed in parasite mitochondria, rough ...
Haning R V RV - - 1993
To study the interrelationships of steroids within the follicle, combined 6-h infusions of [3H]dehydroepiandrosterone sulfate and [14C] testosterone ([14C]T) were performed in four normal women treated with menotropins who were undergoing medically indicated surgery. The concentrations of tracer and/or nonisotopic dehydroepiandrosterone sulfate, androst-5-ene-3 beta,17 beta-diol sulfate, androst-5-ene-3 beta,17 beta-diol, dehydroepiandrosterone, ...
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