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Results 401 - 450 of 625
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Cox J E - - 1988
We investigated the anatomical basis of paraventricular (PVN) and ventromedial (VMH) hypothalamic hyperphagia. Asymmetrical electrolytic lesions, damaging the VMH and PVN contralaterally, produced significant hyperphagia and weight gains (mean = 257.2 g) almost three times those of controls (89.8 g) during 56 postsurgical days. Weight gain in these rats was ...
Whishaw I Q - - 1988
Developments of a procedure to study two movements, food wrenching (stealing food from a conspecific) and dodging (escaping with food from a conspecific), used in the competition for food by rats is described. These include, (A) procedures for adaptation, (B) procedures for filming and scoring, and (C) procedures for measuring ...
Rattan A K - - 1988
Injections into third ventricle of brain of either 4 m Molar or 8 m Molar of GABA were given to intact and ovariectomized female rats to evaluate the effects of these dosages on body weight, food intake, water intake and blood glucose levels. Statistically significant reduction in food and water ...
Bowden C R - - 1988
Histidyl-proline diketopiperazine [cyclo(His-Pro)], a metabolite of thyrotropin releasing hormone (TRH), has been reported to decrease food intake of rats in a variety of feeding models following intracerebroventricular (ICV) injection. We have re-evaluated the anorectic effects of cyclo(His-Pro) on food deprivation-induced and spontaneous feeding. When injected ICV at the end of ...
Whishaw I Q - - 1988
Sensorimotor behavior in unilateral decorticate and unilateral dopamine-depleted rats was studied in a naturally occurring social interaction in which rats compete for food with relatively stereotyped species-typical responses. In the interaction a "robber" attempts to wrest food from a feeding "victim," which in turn protects the food by making rapid ...
Cornblath D R - - 1988
Animals with experimentally induced neuropathies frequently fail to gain weight normally and appear poorly nourished. To determine whether or not malnutrition alone contributes to peripheral nerve dysfunction in these disorders, we subjected healthy 40-day-old rats to three grades of food restriction. After 4 weeks, food-restricted rats weighed 203 +/- 5 ...
Lafont J - - 1988
It is now generally admitted that phytohemagglutinin (PHA) constitutes the main factor responsible for the dietary toxicity of raw kidney beans. In the growing rat, an impairment of growth is the unique expression of a malnutrition syndrome. The aim of this work was to precise to what extent the intestinal ...
McGowan M K - - 1988
Electrolytic lesions in the MPO of rats had no significant effects on ad lib food and water intake, but impaired the drinking response to 1 M NaCl. Large MPO lesions also produced a persistent increase in plasma osmolality. In Experiment 2, we depleted neurons from the MPO of rats by ...
Refinetti R - - 1988
Rats kept either at thermoneutrality (29 degrees C) or in the cold (19 degrees C) were fed either at thermoneutrality or in the cold. Rats kept in the cold ingested consistently more food than rats kept at thermoneutrality. Also, independently of nature temperature, rats fed in the cold ingested more ...
Tews J K - - 1988
GABA included in the diet is known to reduce food intake and growth of rats fed a low protein diet. Experiments were designed to determine if GABA or other small neutral amino acids would affect food intake if they were administered separately from the diet, and if such amino acids ...
Kumar B A - - 1988
To analyze further the role of corticosterone (CORT) in the control of feeding behavior, we examined the impact of adrenalectomy (ADX) and chronic CORT implants on the food intake and macronutrient self-selection patterns of adult male rats at different periods of the diurnal cycle. Consistent with a separate study of ...
Guilland J C - - 1988
Two experiments examined the contribution of the two catecholamines--epinephrine (EPI) and norepinephrine (NE)--to the control of food intake and body weight gain in male rats during chronic exercise. Urinary excretion of both catecholamines rose significantly and was positively correlated to food intake inhibition (NE, n = 54, r = 0.394, ...
Currie R W - - 1988
Isolated and perfused rat hearts can be maintained for up to 2.5 h with minimal synthesis of a stress protein with a relative mass (Mr) of 71 kilodaltons (SP71). Isolated hearts, subjected to 17 h of cold (4 degrees C) ischemia, upon perfusion (37 degrees C) synthesize a large amount ...
Albert D J - - 1988
Castrated rats with medial hypothalamic lesions or sham lesions and castrated rats with testosterone implants or sham implants were placed on a 23-hr food deprivation schedule, adapted to a highly palatable liquid food, and then housed in pairs. The pairs were observed in competition for the highly palatable food over ...
Pisa M - - 1988
The objective of this study was to examine the hypothesis of somatotopically organized motor functions in the striatum. In Experiment 1, ibotenate-induced lesions of the rostrolateral striatum in rats produced a transient decrease of ad libitum food intake, a more enduring decrease of body weight, and chronic impairments of food ...
Grey V L - - 1988
The oral intake of food is important for the observed compensatory hyperplasia in the remnant small intestine after resection but the molecular events governing this response are not known. Peptides, of molecular weight 4500 and 1000 daltons, present in the the proximal intestine for 96 hr after resection and mitogenic ...
Newberne P M - - 1988
Food additives, drugs, and other chemicals are known to influence the lower gastrointestinal tract under some defined conditions, resulting in morphological alterations in the mucosa and other tissues, deranged absorption and excretion of nutrients, and, in some cases, injury to other organs and tissues as a secondary phenomenon. Generally, in ...
Gorgels T G - - 1987
The neuron-specific phosphoprotein B-50 is a major substrate of kinase C in fetal nerve growth cones, neonatal neural and synaptosomal plasma membranes. B-50 is identical to a growth-associated protein GAP43. Similarly, increases in B-50 occur during rat brain development, neuronal differentiation and axon regeneration. To document the relation between the ...
Russell J C - - 1987
The rat is widely used in studies of the metabolic and physiological effects of physical exercise. The most commonly used form of exercise is running on treadmills or mechanically driven running wheels. Rats will not voluntarily run significant distances, under normal circumstances. If rats are exposed to running wheels with ...
Jeffrey P - - 1987
Variable amounts of food have been observed in the stomachs of male rats following an overnight fast. The effects of diet and diet type on the amount of residual food left in the stomach and on fat deposition and liver weight in the male rat were investigated. The implications of ...
Solomon S S - - 1987
The sensitivity to lipolytic agents is altered in diabetic vs. control animals. Because of its role as a diabetogenic hormone and its ability to elicit lipolysis, GH was studied in isolated fat cells (IFC) from control and streptozotocin-diabetic (STZ-DM) rats. IFCs from the epididymal fat of 150 to 200-g normal ...
George J K - - 1987
To investigate whether the circulating level of neurotensin (NT) in the rat is related to either the 24-h pattern in food consumption or environmental lighting conditions, the plasma level of NT was determined every 4 h in the hepatic-portal vein and the abdominal aorta over the course of 24 h. ...
Contreras S - - 1987
The effect of daily doses of 80 mg/kg (intraperitoneal) of alpha-methylparatyrosine, AMPT (inhibitor of tyrosine hydroxylase) on the voluntary consumption of ethanol, water, and solid food was studied in rats of both sexes belonging to the UChA (lower ethanol consumer) and UChB (high ethanol consumer) strains. The consumptions during the ...
Papp M - - 1987
The effects of 6-hydroxydopamine (6-OHDA) lesions in the ventral tegmental area (VTA) or substantia nigra, pars compacta (SN/pC) on the behaviour of hungry rats were examined in a Columbia obstruction box test. The lesions of dopaminergic neurones in the VTA as well as in the SN/pC decreased the number of ...
Good D W - - 1987
Transport of NH3 from loops of Henle to medullary collecting ducts has been proposed to play an important role in renal ammonia excretion. To determine whether transepithelial ammonia concentration gradients capable of driving this transport are present in the inner medulla, micropuncture experiments were performed in control rats and in ...
Flatt P R - - 1987
Subcutaneous implantation of small fragments of a radiation-induced transplantable rat insulinoma into the subscapular region of 16- to 17-week-old male NEDH rats resulted, over a 22-day period, in the progressive development of marked hyperinsulinaemia and severe hypoglycaemia, despite a compensatory increase in food intake. Diurnal changes were examined at 3-hourly ...
Wilson J F - - 1987
To assess the effects of sucrose, low levels of dietary protein, and pregnancy on food intake, sixty-four female rats were assigned to eight groups in a 2 X 2 X 2 design. Food, water, and sucrose intake and rats' weights were measured daily. Pregnant rats offered sucrose with low protein ...
Santos Pinto F N - - 1987
The relationship between food intake and oxygen consumption was studied in a group of 60 rats acclimated at environmental temperatures of either 30 or 10 degrees C. Three separate experiments were performed. In the first, 28 rats were divided into two groups: control, which received 20 and 32 g of ...
Bellinger L L - - 1987
In a previous study we found that while human satietin (h-SAT) suppressed the food intake of rats it was also aversive to them. In the present study rat satietin (r-SAT) was tested for aversiveness in rats fitted with chronic third ventricle (ICV) cannulas. The rats were then given access to ...
Tordoff M G - - 1987
Free-feeding normal and streptozotocin-diabetic rats were allowed to drink 10 ml of 35% glucose solution or an equicaloric 15% corn oil emulsion during the 1st hr of the dark period. While the drinks were available, the rats ate food that contained distinctive flavors such that a particular flavor was always ...
Plata-Salamán C R - - 1987
Evidence indicates that intra-third cerebroventricular (III-ICV) administration of calcitonin suppresses food and water intake of rats. The purpose of this study was to determine whether calcitonin would influence angiotensin II-induced dipsogenesis when simultaneously administered III-ICV. Administration of calcitonin (0.5 U/rat) suppressed food and water intake in male Wistar rats. III-ICV ...
Bellinger L L - - 1987
Satietin is a putative satiety agent when given either peripherally or intracerebroventricularly (ICV). In the present study male Sprague Dawley rats were fitted with chronic third ventricle cannulas. After recovery, Alzet seven day osmotic pumps were inserted subcutaneously and tubing was connected to the cannula. Rats were then infused ICV ...
Plata-Salamán C R - - 1987
The mechanism of the diurnal eating pattern in the rat (eating much more food at night than in the day) is not entirely clear. To further study the influence of environmental lighting on food intake, male rats were maintained in constant 12:12 light-dark cycle (daytime from 0800 to 2000) and ...
Behm R - - 1987
The effect of almitrine on salt appetite, water intake, and renal excretory function was investigated in conscious adult spontaneously hypertensive rats (SHR) of both sexes. The animals were kept singly in metabolic cages and given free access to food, water and 2.5% NaCl-solution. Oral administration of almitrine (0.4 mg/kg) for ...
Solano-Flores L P - - 1986
To assess the relation between the suprachiasmatic nucleus and the locus coeruleus, persistent estrous was induced in female rats by exposure to constant bright light followed with electrolytic damage of the locus coeruleus. Locus coeruleus lesions resulted in a transient loss of persistent estrous indicated by sustained diestrous aspect of ...
Friedman M I - - 1986
Inhibition of glycolysis and fatty acid oxidation by combined treatment with 2-deoxyglucose (2DG) and methyl palmoxirate, or inhibition of glycolysis and lipolysis by combined treatment with 2DG and nicotonic acid synergistically increased food intake in rats. Methyl palmoxirate treatment alone increased food intake in rats fed a high-fat, but not ...
Friedman M I - - 1986
To determine whether glucose and fat metabolism interact to control food intake, rats were administered 2-deoxyglucose (2-DG), which inhibits glucose utilization, and methyl palmoxirate (MP), which inhibits fatty acid oxidation. Combined treatment with 2-DG and MP increased food intake in a synergistic fashion. This synergistic effect was observed even at ...
Weatherford S C - - 1986
Hepatic vagotomized and hepatic portal alloxan-injected rats and their controls were tested for glucagon satiety at three time points during the circadian photoperiod: 6 hr into the light cycle with no food deprivation using a palatable liquid food; at the onset of the dark cycle after 6 hr food deprivation ...
Wager-Srdar S A - - 1986
During lactation food intake increases greatly without an accompanying large increase in body weight; therefore, this physiological state is an excellent example of non-obese hyperphagia. In the present study, we found that cholecystokinin (CCK-8) decreased food intake in lactating and virgin female rats. However, female rats were more resistant to ...
Shor-Posner G - - 1986
Norepinephrine (NE) injected into the paraventricular nucleus (PVN) has a stimulatory effect on feeding behavior and is found to selectively enhance preference for carbohydrate in the rat. The present experiments were conducted to assess the impact of chronic depletion of NE within the PVN on food intake and appetite regulation. ...
Mascarenhas J F - - 1986
Adult female rats were given ad lib access to two pairs of specially prepared diets containing the three macro-nutrients, protein, fat and carbohydrate, in such proportion that both pairs were isocaloric but one pair varied in protein content (45% and 5%) and the other pair in carbohydrate content (70% and ...
Scharrer E - - 1986
The role of fatty acid oxidation in the control of food intake was studied using mercaptoacetate (MA), an inhibitor of fatty acid oxidation. Food intake, plasma free fatty acids (FFA) and ketone bodies, and blood glucose were measured. Rats were fed either a low-fat (LF, 3.33% fat) or a medium-fat ...
Virk M S - - 1986
We determined the effects of phenol and 2,6-dimethoxyphenol (syringol) on N-nitrosomorpholine (NMOR) formation in rats given morpholine and nitrite by gavage. At 30 min post-gavage the recovery (from the stomach, duodenum and blood) of 564 micrograms NMOR was six times higher when administered to rats by gavage with 2 g ...
Shor-Posner G - - 1986
The hypothalamic paraventricular nucleus (PVN) has been found to be sensitive to the feeding stimulatory effects of opiates. The present experiments investigated the effect of systemic morphine (2 mg/kg) on macronutrient selection in freely-feeding and food-restricted rats and assessed the impact of PVN electrolytic and 6-hydroxydopamine lesions on the rats' ...
Osborne B - - 1986
The feeding and drinking behavior was examined in male rats with fornix transections and sham-operated control rats. Total food and water consumption was recorded but supplemented by a pattern analysis of feeding and drinking behavior. The behavior of the rats was continuously monitored during four hour morning and afternoon sessions ...
Simbayi L C - - 1986
Associations between a specific flavour and access to food were studied using a discrimination procedure devised by Holman (1975). This involved giving rats one flavour (e.g. cinnamon) of saccharin solution on some days, and following this by delivery of food, and a second flavour (e.g. wintergreen) on other days which ...
Vergoni A V - - 1986
The synthetic corticotropin ACTH (1-24) (tetracosactide), injected into a brain lateral ventricle after a 24h starvation period or into the ventromedial hypothalamus during the nocturnal feeding phase, markedly inhibited food intake, in rats. In starved rats, the dose of 4 micrograms/rat was maximally effective and reduced food intake by 76.6% ...
Hoffman D C - - 1986
It has been observed in previous research that rats treated with the dopamine receptor antagonist, pimozide, failed to eat palatable food pellets. Two possible interpretations for this effect were evaluated, namely, a reduction in the primary level of food motivation or drug-induced hypokinesia resulting in a subsequent failure to find ...
Plata-Salamán C R - - 1986
Several lines of evidences indicate that insulin affords short- and long-term neuroendocrine signals to modulate ingestive behavior. To further study a possible role of insulin in the control of food intake, male Wistar rats were subjected to various intra-third cerebro-ventricular applications of saline and insulin. Infusion of 2.0 mIU/rat of ...
Stoynev A G - - 1986
The 24-hour variations in 2-hour diuretic and saluretic action of furosemide (4 mg/kg) given at 8, 12, 16, 20, 24 or 4 hr and the circadian rhythms of food and water intake, urine and electrolyte excretion followed for two consecutive days at 4-hour intervals were investigated in suprachiasmatic nuclei (SCN)-lesioned ...
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