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Results 101 - 150 of 649
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Wong K J KJ The Pennsylvania State University, Nutritional Sciences Dept., 110 Chandlee Laboratory, University Park, PA 16802, - - 2009
This study assessed the effects of the opioid antagonist naltrexone, the dopamine 2-like (D2) antagonist raclopride, and the GABA(B) agonist baclofen on consumption of fat/sucrose mixtures (FSM) using a limited access protocol. Sixty male Sprague-Dawley rats were grouped according to two schedules of access (Daily [D] or Intermittent [I]) to ...
De Jonghe Bart C BC Monell Chemical Senses Center, 3500 Market St, Philadelphia, PA 19104, - - 2009
Clay consumption can occur during illness but there has been little work to understand why. To investigate whether consuming clay confers an advantage to the sick animal, we compared the recovery from illness of adult male rats with or without access to kaolin. Illness was induced by injection of 6 ...
Luyten Laura - - 2009
The glucose metabolism in the mediodorsal thalamus (MD) is increased in rats in the activity-based anorexia (ABA) model. In patients, electrical stimulation in hyperactive brain regions reduced symptoms in e.g. major depressive disorder and cluster headache. In two blinded randomised controlled experiments, we therefore examined the effects of high-frequency electrical ...
Ooyama Katsuhiko - - 2009
Previous studies have demonstrated that fatty acid oxidation in the liver may affect food intake. This study examined the influence of preloading of medium-chain triacylglycerol (MCT) on food intake in comparison with long-chain triacylglycerol (LCT). Male rats were fasted for 18 h and then administered LCT or MCT emulsion orally. ...
Shinozaki Tomokazu - - 2008
The effects of fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), were studied in normophagic and food-restriction-induced hyperphagic middle-aged Wistar rats. Normophagic intact Wistar rats were given fluvoxamine (100 mg/kg/d, per os (p.o.)) or vehicle for 10 d. Hyperphagic middle-aged Wistar rats were subjected to 10 d of food restriction; they ...
Verhagen Linda A W - - 2009
Excessive physical activity is commonly described as symptom of Anorexia Nervosa (AN). Activity-based anorexia (ABA) is considered an animal model for AN. The ABA model mimics severe body weight loss and increased physical activity. Suppression of hyperactivity by olanzapine in anorectic patients as well as in ABA rats suggested a ...
Vento Peter J - - 2008
The benzimidazole anthelmintic fenbendazole (FBZ) is a common and effective treatment for pinworm infestation in laboratory animal colonies. Although many investigators have examined the potential for deleterious biologic effects of FBZ, more subtle aspects of the treatment remain untested. Accordingly, we evaluated differences in food intake when healthy male Sprague-Dawley ...
Chiamulera C C Neuropsychopharmacology Laboratory, Section of Pharmacology, Department of Medicine and Public Health, University of Verona, Verona, Italy. - - 2010
Noradrenergic transmission has been implicated in the affective component of relapse to tobacco smoking. Evidence in human and laboratory animals showed that smoking or nicotine administration may cause changes of the noradrenergic system resulting in hyperactivity in this system after cessation. It has been hypothesised that the anti-adrenergic beta-blocker propranolol ...
Germano C M R - - 2008
Melanocortin system and corticotropin releasing hormone (CRH) are implicated in the control of feeding behavior. Besides its anorexigenic effect on food intake, CRH is one of the most important regulators of hypothalamic-pituitary-adrenal (HPA) axis activity. Therefore, there could be an interplay between HPA axis activity and melanocortin system. We investigated ...
Martin Megan M - - 2008
Converging lines of evidence have supported a role for the nucleus basalis magnocellularis (NB) in attentional mechanisms; however, debate continues regarding the role of the medial septum in behavior (MS). Recent studies have supported a role for the septohippocampal system in the online processing of internally generated cues. The current ...
Hofbauer Karl G - - 2008
OBJECTIVE: Active immunization in rats may serve several purposes: the production of a disease-like phenotype, the generation of pharmacologic tools, and the development of clinically useful therapies. We selected the melanocortin-4 receptor (MC4R) as a target because its blockade could provide a treatment for anorexia and cachexia. METHODS: We used ...
Rehm Sabine - - 2008
Reduced food consumption and associated lower body weights may occur in subacute toxicity studies. The short-term effects of food restriction (FR) on body and reproductive organ weights, hormones, and testis histology were assessed in Sprague-Dawley rats fed 20% to 36% less (21 g feed/day) than rats fed ad libitum (AL) ...
Lyaruu Donacian M - - 2008
Renal impairment in children is associated with tooth defects that include enamel pitting and hypoplasia. However, the specific effects of uremia on tooth formation are not known. In this study, we used rat mandibular incisors, which continuously erupt and contain all stages of tooth formation, to characterize the effects of ...
Pettenuzzo Leticia Ferreira - - 2008
Anorectic effects of caffeine are controversial in the literature, while stress and obesity are growing problems in our society. Since many stressed people are coffee drinkers, the objective of the present study was to evaluate the effect of stress and chronic administration of caffeine on feeding behavior and body weight ...
Swithers Susan E SE Department of Psychological Sciences and Ingestive Behavior Research Center, Purdue University, West Lafayette, IN 47907-1364, USA. - - 2008
Adult male rats have been demonstrated to increase food intake in response to administration of drugs that interfere with oxidation of fatty acids (e.g. methyl palmoxirate and mercaptoacetate [MA]), effects that are larger in animals maintained on a high-fat diet. In contrast, while administration of MA has been reported to ...
Onyechi, U A; ;
<i>Detarium microcarpium</i> is a legumnous plant food used traditionally among the Ibos in the SouthEastern part of Nigeria as a thickening agent in vegetable soups. <i>Detarium</i> is largey uncharacterised and under exploited. There is a dearth of information in the lterature on this plant ood. The aim of the study ...
Thanos Panayotis K - - 2008
In the current study, we examined the effect of the selective D(3) receptor antagonists SB-277011A and NGB 2904 on operant food self-administration (FSA) in Zucker obese and lean rats. Obese (Ob) and lean (Le) Zucker rats were maintained under a restricted feeding regimen (70% of ad-libitum rat chow) and were ...
Kishida Taro - - 2008
OBJECTIVE: Estrogens downregulate eating behavior, and soy isoflavones are known to be estrogenic agents. We aimed to examine whether the estrogenic property of soy isoflavones can affect food intake and body weight. METHODS AND PROCEDURES: Seven-week-old male, female, and ovariectomized (OVX) Sprague-Dawley rats were given free access to a diet ...
Heinsbroek , Angelique Catharina ...
Nowadays, we live in a 24/7-economy, with high psychological demands and plenty of (high caloric) food. In this society, maternal undernutrition may be less relevant because food is so abundant. Other factors, like stress, maternal obesity and high fat diet, may be more relevant for our current society and can ...
Whishaw Ian Q - - 2008
Skilled reaching for food is an evolutionary ancient act and is displayed by many animal species, including those in the sister clades of rodents and primates. The video describes a test situation that allows filming of repeated acts of reaching for food by the rat that has been mildly food ...
Landry Glenn J - - 2007
Restricted daytime feeding generates food-anticipatory activity (FAA) by entrainment of a circadian pacemaker separate from the light-entrainable pacemaker located in the SCN. The dorsomedial hypothalamic nucleus (DMH) has been proposed as the site of food-entrainable oscillators critical for the expression of FAA, but another study found no effects of complete ...
Walker S C - - 2007
The pedunculopontine tegmental and cuneiform nuclei are adjacent structures in the mesopontine tegmentum. The pedunculopontine has attracted interest because of its extensive reciprocal connections with corticostriatal systems and possible role in complex behavioral and cognitive processes; the cuneiform is thought to be part of a neural system important for organizing ...
Kwun In-Sook - - 2007
Zn deficiency reduces food intake and growth rate in rodents. To determine the relationship between Zn deficiency and the regulation of food intake, we evaluated leptin gene expression in epididymal white adipose tissue (eWAT), and hypothalamic corticotropin-releasing hormone (hCRH) and hypothalamic neuropeptide Y (hNPY) of rats Zn-deficient only to show ...
White Wesley - - 2007
Following administration of a moderate dose of amphetamine, rats appear to pass through a sequence of physiological/psychological states, including stimulant and depressant states. The present research evaluated whether these states could be inferred from time-dependent changes in feeding-related measures. Male rats were housed in individual stations (light-dark 12-12 h, free ...
Rinaman Linda - - 2007
We previously reported that noradrenergic (NA) neurons in the nucleus of the solitary tract (NST) are necessary for exogenous CCK octapeptide to inhibit food intake in rats. To determine whether NST NA neurons also are necessary for lithium chloride (LiCl) to inhibit food intake and/or to support conditioned avoidance behavior, ...
Nakao Reiko - - 2007
Several specific locations in brain, including pyriform cortex and hypothalamus, are associated with regulation of food intake. Although lesions of these locations significantly alter food intake, their involvement in the selection of macronutrients is not well characterized. In this study, we examined distinct effects of anterior pyriform cortex (APC) and ...
Mahía J J Psicobiología, Universidad de Granada, Campus de Cartuja, Granada, 18071, Spain. - - 2007
The aim of this study was to examine the dipsogenic mechanisms involved in the recently discovered tuberomammillary (TM)-mediated polydipsia. Rats with bilateral electrolytic lesions of each TM subnucleus underwent several dipsogenic treatments, both osmotic and volemic. Animals with ventral (E2) or medial TM lesions (E3 or E4) showed a potentiated ...
Petrovich Gorica D GD Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA. - - 2007
Motivation plays an important role in the control of food intake. A cue that acquires motivational properties through pairings with food consumption when an animal is hungry can override satiety and promote eating in sated rats. This phenomenon of conditioned potentiation of feeding is mediated by connections between the forebrain ...
Alaverdashvili Mariam - - 2007
Amphetamine (AMPH) has been proposed as a treatment for post-stroke motor deficits when coupled with symptom-relevant physical rehabilitation. Whereas a number of experimental studies report improvements in endpoint measures of skilled reaching for food by rats, there has been no assessment of whether beneficial effects extend to overcoming learned non-use ...
Moran Timothy H - - 2007
Curt Richter's seminal contributions to the field of psychobiology continue to enlighten us today. His approaches to scientific questions, his ability to design ways of allowing his research subjects (usually rats) to answer his questions and his unique style of data presentation inform current investigations into the biological bases of ...
Ellsworth Bruce A - - 2007
Structure-activity relationships for a series of pyrazine carboxamide CB1 antagonists are reported. Pharmaceutical properties of the series are improved via inclusion of hydroxyl-containing sidechains. This structural modification sufficiently improved ADME properties of an orally inactive series such that food intake reduction was achieved in rat feeding models. Compound 35 elicits ...
Cottone Pietro - - 2008
Binge eating and an increased role for palatability in determining food intake are abnormal adaptations in feeding behavior linked to eating disorders and body weight dysregulation. The present study tested the hypothesis that rats with limited access to highly preferred food would develop analogous opioid-dependent learned adaptations in feeding behavior, ...
Whishaw I Q - - 2007
Reaching for food, or skilled reaching, is used as a test of basal ganglia function in preclinical studies as well as studies of human neurological conditions. Although changes in the end-point measure of success document the effects of neurotoxic cellular damage to the caudate-putamen and its treatment in rodents, there ...
Chirino Rosario - - 2007
Maternal behavior is induced in virgin female rabbits (normally unresponsive to foster pups) by removing the accessory olfactory bulbs. To determine if the main olfactory system (MOS) plays a similar inhibitory role in the present work we investigated the effect of lesioning the olfactory epithelium with a ZnSO(4) spray on ...
Stashkevich I S - - 2007
After 48-h food deprivation,Wistar rats were trained to reach a food sphere from a narrow horizontal feeder tube with one paw, with a free choice of limb. The animals used both limbs at the initial stages of training--seizing of food with one paw could alternate with seizing using the other ...
El-Amamy Heather H Johns Hopkins University, Department of Psychological & Brain Sciences, 3400 North Charles Street, Baltimore, MD 21218, - - 2007
Recent evidence suggests that the amygdala central nucleus (CeA) and midbrain-striatal dopamine systems are critically involved in the alteration of attentional and emotional processing of initially neutral stimuli by associative learning. In rats, the acquisition of learned orienting responses (ORs) to visual cues paired with food is impaired by lesions ...
Jarosz Patricia A - - 2007
A previous study in our laboratory using Sprague-Dawley (SD) male rats showed that conditioned place preferences (CPPs) can be learned to two different high-caloric "snack foods"--one high in sugar (Froot Loops cereal: FL) vs. one high in fat (Cheetos: C), and that both preferences were mediated by endogenous opioids. Using ...
Peter Jean-Christophe - - 2007
Functionally active antibodies (Abs) against central G-protein-coupled receptors have not yet been reported. We selected the hypothalamic melanocortin-4 receptor (MC4-R) as a target because of its crucial role in the regulation of energy homeostasis. A 15 amino acid sequence of the N-terminal (NT) domain was used as an antigen. This ...
Aimé P - - 2007
Olfaction plays a fundamental role in feeding behavior, but changes in olfactory acuity according to feeding states have never been precisely demonstrated in animals. The present study assesses the olfactory detection performance of fasted or satiated rats placed under a strictly controlled food-intake regimen. We did this using a conditioned ...
Landry G J - - 2007
Rats can anticipate a fixed daily mealtime by entrainment of a circadian timekeeping mechanism anatomically separate from the light-entrainable circadian pacemaker located in the suprachiasmatic nucleus. Neural substrates of this food-entrainable circadian system have not yet been fully elucidated. A role for the thalamic paraventricular nucleus (PVT) is suggested by ...
Hermer-Vazquez Linda L SUNY Health Science Center, Brooklyn, NY 11203, United States. - - 2007
Humans and non-human animals make use of sensory hierarchies in "selecting" strategies for solving many cognitive and behavioral tasks. Often, if a preferred type of sensory information is unavailable or is not useful for solving a given task, the animal can switch to a lower-priority strategy, making use of a ...
Sibilia V - - 2006
We studied the effect of the acute central administration of obestatin on food intake and body weight in short-term starved male rats, and those of 28-day continuous intracerebroventricular (icv) infusion of obestatin in free feeding rats. In 16-h starved rats, obestatin induced a trend toward a reduction of food intake ...
Payne Martha E - - 2007
BACKGROUND: Studies indicate that diet may be related to the occurrence of brain lesions. The cross-sectional association between food intake and brain lesion volumes in late-life depression was examined in a cohort of elderly individuals with current or prior depression. METHODS: Food intake was assessed in 54 elderly vascular depression ...
Ivliev D A DA Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow. - - 2006
Neuron activity was recorded from the basal forebrain of rats, including the mixed area of the ventral pallidum, substantia innominata, and mid part of Meynert's nucleus. The base of the forebrain was found to contain neurons (40% of all neurons recorded) which altered their activity on acquisition of a food-procuring ...
Pisu Maria Giuseppina - - 2006
Stressful stimuli and anxiogenic drugs increase the plasma and brain concentrations of neuroactive steroids. Moreover, in rats trained to consume their daily meal during a fixed period, the anticipation of food is associated with changes in the function of various neurotransmitter systems. We have now evaluated the effects of anticipation ...
Wallace Douglas G - - 2006
Operant procedures combined with pharmacological manipulations have implicated a role for the dopaminergic system in the perception and production of temporal intervals. Because studies have suggested that animals use temporal information to organize food protection behavior, the current study investigates whether dopaminergic systems are involved in timing during this natural ...
Silveira Patricia Pelufo - - 2006
We have previously demonstrated that neonatal handling increases sweet food ingestion. In the present study, we examined whether food intake, using different kinds of food, is altered in neonatally handled animals, with or without inducing satiety using a sucrose solution. Abdominal fat, glycemia and hormones linked to appetite including leptin, ...
Thorpe Christina M - - 2006
Rats were trained on an interval time-place learning (TPL) task in which the location of food availability depended on the time since the start of the session. Each of four levers (numbered 1, 2, 3, 4) provided food on an intermittent schedule for two nonconsecutive 3-min periods. The order in ...
Messina Michelina M - - 2006
Estradiol exerts an inhibitory effect on food intake via interactions with anorexigenic peptides, like cholecystokinin, that function to decrease meal size. It is currently unknown whether estradiol also interacts with orexigenic compounds implicated in the physiological control of food intake. Thus, the primary goal of this study was to determine ...
Silveira P P - - 2006
Neonatal handled rats ingest more sweet food than non-handled ones, but it was documented only after puberty. Here, we studied the purinergic system in the nucleus accumbens, a possible target for the alteration in the preference for palatable food. We measured the ATP, ADP and AMP hydrolysis mediated by ectonucleotidases ...
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