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Stappaerts Jef J Drug Delivery and Disposition, KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Leuven, - - 2014
The mixed micelles and vesicles present in the intraluminal environment of the postprandial state exhibit suitable solubilizing capacities for lipophilic drugs. This increase in solubility, however, is accompanied by a decrease in the free fraction caused by micellar entrapment of these lipophilic compounds. In this study, both simulated and aspirated ...
Wang Juan J 1 College of Light Industry and Food Sciences, South China University of Technology , Guangzhou, China - - 2014
Abstract Banana resistant starch (BRS) was extracted to investigate the structural properties of BRS, its effects on the gastrointestinal transit, and dejecta of normal and experimentally constipated mice. The mouse constipation model was induced by diphenoxylate administration. The BRS administered mice were divided into three groups and gavaged with 1.0, ...
de Kivit Sander S Division of Digestive Diseases and Nutrition, Rush University Medical Center, Chicago, IL, USA. Electronic address: - - 2014
Alterations in the gut microbiota composition are associated with food allergy. Toll-like receptors (TLR) respond to microbial stimuli. We studied the effects of ligation of TLR on intestinal epithelial cells (IEC) in preventing an allergic effector response. IEC monolayers (T84 cells) were co-cultured with CD3/28-activated PBMC from healthy controls or ...
Alassane-Kpembi Imourana I UMR 1331 Toxalim, Research Center in Food Toxicology, INRA, 180 chemin de Tournefeuille, BP93173, 31027, Toulouse cedex 03, - - 2014
In case of mycotoxin contaminations, food and feedstuff are usually contaminated by more than one toxin. However toxicological data concerning the effects of mycotoxin combinations are sparse. The intestinal epithelium is the first barrier against food contaminants and this constantly renewing organ is particularly sensitive to mycotoxins. The aim of ...
Westerhout Joost J The Netherlands Organization for Applied Scientific Research (TNO), Zeist, The - - 2014
A reliable prediction of the oral bioavailability in humans is crucial and of high interest for pharmaceutical and food industry. The predictive value of currently used in silico methods, in vitro cell lines, ex vivo intestinal tissue and/or in vivo animal studies for human intestinal absorption, however, is often insufficient, ...
Cabrera Carmen M CM Immunology Section, Hospital General Universitario de Ciudad Real, Avda. Obispo Rafael Torija s/n, 13005, Ciudad Real, Spain, - - 2014
Food allergy represents an increasing health problem, with children being the most affected population. The symptoms can appear within minutes or hours of ingesting the offending food, producing skin manifestations, respiratory, gastrointestinal and anaphylactic reactions in the severe forms. Food allergy is established by the loss of tolerance to food ...
de Sousa Moraes Luís Fernando LF Department of Nutrition and Health, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil - - 2014
Celiac disease (CD) is a common chronic autoimmune enteropathy caused by gluten intake. To date, the only therapy for CD is the complete exclusion of dietary sources of grains and any food containing gluten. It has been hypothesized that the intestinal microbiota is somehow involved in CD. For this reason, ...
Wang Chao C Department of Food Science and Technology, Jinan University, Guangzhou, 510632, China, - - 2014
Bioaccessibility represents the maximum amount of pollutant ingested with food that is available for intestinal absorption. The measurement of bioaccessibility can achieve a more accurate risk assessment. Thus, in this study, the bioaccessibility of raw/microwave-cooked store-bought food including carrot, potato, white radish, lotus root, sweet corn, long grain rice, soybean, ...
van Avesaat M M 1] Top Institute of Food and Nutrition, Wageningen, the Netherlands [2] Division of Gastroenterology and Hepatology, Department of Internal Medicine, NUTRIM, Maastricht University Medical Center, the - - 2014
Background:Activation of the ileal brake, by infusing lipid directly into the distal part of the small intestine, alters gastrointestinal motility and inhibits food intake. The ileal brake effect on eating behavior of the other macronutrients is currently unknown.Objective:The objective of this study was to investigate the effects of ileal infusion ...
Eagle Ken K 25219 Dunlap Meadow Ln, Katy TX 77494. Electronic address: - - 2014
Five recent reviews have analyzed trials on the association between artificial food colors and ADHD; the 50 underlying studies and the reviews in aggregate were inconclusive. Recent work has shown human in vivo SULT1A inhibition leading to incremental catecholamines, and an inverted-U relationship between brain catecholamines and proper functioning of ...
Allen Heather K HK Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa 50010; email: - - 2014
The human food chain begins with upwards of 1,000 species of bacteria that inhabit the intestinal tracts of poultry and livestock. These intestinal denizens are responsible for the health and safety of a major protein source for humans. The use of antibiotics to treat animal diseases was followed by the ...
Cuervo Adriana A Department of Functional Biology, Facultad de Medicina, University of Oviedo, C/Julián Claverı́a s/n, 33006 Oviedo, Asturias, - - 2014
Several studies have addressed the use of dietary fibers in the modulation of intestinal microbiota; however, information about other highly correlated components in foods, such as polyphenols, is scarce. The aim of this work was to explore the association between the intake of fibers and polyphenols from a regular diet ...
Tinoco Ana B AB Complutense University of Madrid, - - 2014
Oleoylethanolamide (OEA) is a bioactive lipid mediator, produced in the intestine and other tissues, which is involved in energy balance regulation in mammals, modulating feeding and lipid metabolism. The purpose of the present study was to investigate the presence and possible role of OEA on feeding regulation in goldfish (Carassius ...
Faust James J JJ Molecular and Cellular Biosciences, School of Life Sciences, Arizona State University, Tempe, AZ, 85287-4501, - - 2014
Bulk- and nano-scale titanium dioxide (TiO2) has found use in human food products for controlling color, texture, and moisture. Once ingested, and because of their small size, nano-scale TiO2 can interact with a number of epithelia that line the human gastrointestinal tract. One such epithelium responsible for nutrient absorption is ...
Gou Ju-Hua JH Department of Gastroenterology, First Affiliated Hospital of Chongqing Medical University, Chongqing, - - 2014
A patient with acute obscure gastrointestinal bleeding was found to have a large amount of food retention in the stomach after fasting for >12 hours. We tried to adjust the patient's body position to facilitate capsule endoscopic examination. The patient laid on the bed on his right side, which is ...
Alvarez-Sieiro Patricia P Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300, Villaviciosa, Asturias, - - 2014
Prolyl endopeptidases (PEP) (EC 3.4.21.26), a family of serine proteases with the ability to hydrolyze the peptide bond on the carboxyl side of an internal proline residue, are able to degrade immunotoxic peptides responsible for celiac disease (CD), such as a 33-residue gluten peptide (33-mer). Oral administration of PEP has ...
Meyer Rosan R Great Ormond Street Children's Hospital, Gastroenterology, London, - - 2014
There is paucity of data on the prevalence of feeding difficulties in Food Protein Induced Gastrointestinal Allergies (FPIGA) and their clinical characteristics. However, it is a commonly reported problem by clinicians. We set out to establish the occurrence of feeding difficulties in children with FPIGA, the association with gastrointestinal and ...
Zhang Jiachao J Key Laboratory of Dairy Biotechnology and Bioengineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, 010018, P. R. - - 2014
Probiotics are believed to help to maintain a healthy balance of the human gut microbiota. Lactobacillus casei Zhang (LcZ) is a novel potential probiotic isolated from the naturally fermented food koumiss. To better understand the impact of this potential probiotic on human intestinal microbiota, 24 subjects were randomly recruited for ...
Ribnicky David M DM Rutgers, The State University of New Jersey, School of Environmental and Biological Sciences, New Brunswick, New Jersey, USA. Electronic address: - - 2014
Scientifically validated food-based interventions are a practical means of addressing the epidemic of metabolic syndrome. An ethanolic extract of Artemisia dracunculus L. (PMI-5011) containing bioactive polyphenols, such as 2', 4'-dihydroxy-4-methoxydihydrochalcone (DMC-2), improved insulin resistance in vitro and in vivo. Plant polyphenols are concentrated and stabilized when complexed to protein-rich matrices, such as ...
Kheirandish Farnaz F Department of Parasitology and Mycology, School of Medicine, Lorestan University of Medical Sciences, 381351698, Department of Parasitology and Mycology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. Tel/Fax: +98 661 6200133, P.O. Box: 381351698. - - 2014
Parasitic infection is one of the problems that affect human health, especially in developing countries. In this study, all of the fast food shops, restaurants, and roast meat outlets of Khorramabad (Western Iran) and all the staff employed by them, some 210 people, were selected through a census and their ...
- - 2014
In February, the U.S. Food and Drug Administration approved an ingestible, pill-sized video camera called PillCam COLON to look for polyps in patients who have incomplete colonoscopies.
Noti Mario M Department of Microbiology, University of Pennsylvania, Philadelphia; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia; Division of Experimental Pathology, Institute of Pathology, University of - - 2014
Exposure to food allergens through a disrupted skin barrier has been recognized as a potential factor in the increasing prevalence of food allergy. We sought to test the immunologic mechanisms by which epicutaneous sensitization to food allergens predisposes to intestinal food allergy. Mice were epicutaneously sensitized with ovalbumin or peanut ...
Hassan Kareem K Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, The University of Arizona, Tucson AZ, - - 2014
Celiac disease is a widespread disorder caused by intolerance to gluten, a common protein in food. Currently, a life-long gluten-free diet is the only available treatment for patients with celiac disease. However, adherence to gluten-free diet is difficult due to the widespread use of wheat-derived gluten in the food industry. ...
Hayes James J Departments of Biology and Biochemistry, Memorial University of Newfoundland, St. John's, NL, A1B 3X9 - - 2014
The cunner, Tautogolabrus adspersus, is a marine teleost endemic to the cold waters of the Northwest Atlantic Ocean. The cunner is non-migratory and is known for its remarkable ability to endure the freezing winter months with little to no food by entering a torpid/dormant state. To evaluate the physiological strategies ...
Weiner Myra L ML Toxpertise, LLC , Princeton, NJ , - - 2014
Abstract Carrageenan (CGN) is a seaweed-derived high molecular weight (Mw) hydrocolloid, primarily used as a stabilizer and thickener in food. The safety of CGN regarding its use in food is reviewed. Based on experimental studies in animals, ingested CGN is excreted quantitatively in the feces. Studies have shown that CGN ...
Dailey Megan J MJ University of Illinois, - - 2014
Intestinal nutrient infusions result in variable decreases in food intake and body weight based on the nutrient type and the specific intestinal infusion site. We previously found that intrajejunal infusions of a fatty acid and glucose, but not casein hydrolysate, decreases food intake and body weight in lean chow-fed laboratory ...
Arena Mattia P MP S.A.F.E. Department, University of Foggia, Via Napoli 25, 71100 Foggia, Italy. - - 2014
Currently, the majority of prebiotics in the market are derived from non-digestible oligosaccharides. Very few studies have focused on non-digestible long chain complex polysaccharides in relation to their potential as novel prebiotics. Cereals β-glucans have been investigated for immune-modulating properties and beneficial effects on obesity, cardiovascular diseases, diabetes, and cholesterol ...
Meyer-Gerspach A C AC Department of Biomedicine and Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, - - 2014
Obesity is caused by an imbalance between food intake and energy expenditure. In recent decades the gastrointestinal tract has received growing attention as a control parameter for the regulation of appetite and food intake, however regulatory circuits and their interactions are complex. The basic understanding on the role of the ...
Zheng Xiaoting X Institute of Geology and Paleontology, Linyi University, Linyi, Shandong, China; Tianyu Natural History Museum of Shandong, Pingyi, Shandong, - - 2014
A crop adapted for an herbivorous diet of seeds has previously been documented in the Early Cretaceous birds Sapeornis and Hongshanornis. Here we report on several specimens of Yanornis that preserve a crop containing fish. One specimen preserves two whole fish in the oesophagus, indicating that Early Cretaceous birds shared ...
Nickerson Kourtney P KP Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of - - 2014
In the latter half of the 20th century, societal and technological changes led to a shift in the composition of the American diet to include a greater proportion of processed, pre-packaged foods high in fat and carbohydrates, and low in dietary fiber (a "Western diet"). Over the same time period, ...
Mitsuoka Tomotari T Professor Emeritus, The University of Tokyo, - - 2014
Recent advances in intestinal microbiota research are the background for the appearance of functional foods. Lactic fermentation products are included in the functional foods and classified into 3 groups based on their mechanisms of action: probiotics, prebiotics and biogenics. Probiotics are viable microorganisms, such as lactobacilli and bifidobacteria, that beneficially ...
Lin Fangjun F Department of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, 46# Xinkang Road, - - 2013
The protein nucleobindin-2 (NUCB2) was identified over a decade ago and recently raised great interest as its derived peptide nesfatin-1 was shown to reduce food intake and body weight in rodents. However, the involvement of NUCB2 in feeding behavior has not well been studied in fish. In the present study, ...
de Theije Caroline G M CG Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands. Electronic address: - - 2013
Food allergy has been suggested to contribute to the expression of psychological and psychiatric traits, including disturbed social behaviour and repetitive behaviour inherent in autism spectrum disorders (ASD). Most research in this field receives little attention, since fundamental evidence showing direct effects of food allergic immune responses on social behaviour ...
Yamaki Kouya K Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Hyogo 658-8558, Japan. Electronic address: - - 2013
To clarify the role of Janus kinase (JAK) in and the efficacy of JAK inhibitors on food allergy, we investigated the effect of the clinically available JAK inhibitor ruxolitinib on mouse food allergy and the functions of cultured mast cells in vitro. Anaphylactic symptoms including diarrhea and decreases in body ...
Tordesillas L - - 2013
Since intestinal absorption of food protein can trigger an allergic reaction, the effect of plant food allergen on intestinal epithelial cell permeability and its ability to cross the epithelial monolayer was evaluated. To study the interaction of Pru p 3 with intestinal epithelium, its natural entrance, analyzing transport kinetics and ...
Scaldaferri F F Medical Pathology, Department of Internal Medicine, Gastroenterology Division, Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Rome, Italy. - - 2013
Intestinal gases are the expression of metabolic activity of gut microbiota in the gut, particularly carbohydrates in the case of H2, CH4. Alterations in composition of gases and air handling, directly or upon challenge with food are relevant for GI and extra-GI diseases. Assessing gas composition in breath can be ...
Date Yasuhiro Y RIKEN Center for Sustainable Resource Science, 1-7-22 Suehirocho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehirocho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, - - 2014
The aim of this work was to develop a simple and rapid in vitro evaluation method for screening and discovery of uncharacterised and untapped prebiotic foods. Using a NMR-based metabolomic approach coupled with multivariate statistical analysis, the metabolic profiles generated by intestinal microbiota after in vitro incubation with feces were ...
Salazar Nuria N a Department of Microbiology and Biochemistry of Dairy Products , Instituto de Productos Lácteos de Asturias (IPLA-CSIC) , Villaviciosa , Asturias , - - 2013
Objective: The development of functional foods for microbiota modulation in the elderly constitutes an interesting strategy. However, for such development, specific targets, not just in terms of microbiota but also considering immune and nutritional parameters, should be identified in this population. Methods: We analyzed the intestinal microbiota and immune parameters ...
Lied Gülen Arslan - - 2013
Majority of the patients with perceived food hypersensitivity have irritable bowel syndrome (IBS), and a significant proportion of IBS patients also attribute their gastrointestinal complaints to food items. Different factors such as disturbed intestinal fermentation, enteric dysmotility, post-infectious changes and altered microbial flora in the colon as well as psychological ...
Hessel Stefanie - - 2013
Polycyclic aromatic hydrocarbons (PAHs) are well-known food contaminants comprising compounds with carcinogenic properties. Pyrene (PYR) is an important non-carcinogenic PAH because its metabolites are frequently used as biomarkers to assess human PAH exposure. This study investigated for the first time the formation and transport of PYR metabolites in the human ...
De Vadder Filipe - - 2013
Mu-opioid receptors (MORs) are known to influence food intake at the brain level, through their involvement in the food reward system. MOR agonists stimulate food intake. On the other hand, MOR antagonists suppress food intake. MORs are also active in peripheral organs, especially in the small intestine where they control ...
Maurer J M - - 2013
ColoPulse tablets are an innovative development in the field of oral drug delivery and are characterized by a colon-specific release. Until now ColoPulse dosage forms (only capsules) have been studied in healthy volunteers having a standardized breakfast three hours after administration but not in specific patient groups and not with ...
Borel P P a INSERM, UMR1062, Nutrition, Obesity and Risk of Thrombosis , F-13385 , Marseille , - - 2013
Abstract There has been renewed interest in vitamin D since numerous recent studies have suggested that besides its well-established roles in bone metabolism and immunity, vitamin D status is inversely associated with the incidence of several diseases, e.g. cancers, cardio-vascular diseases and neurodegenerative diseases. Surprisingly, there is very little data ...
Liu Tianlong - - 2013
Recent advances in design and controllable synthesis of rattle-type silica nanoparticles have led to a dramatic expansion of their potential drug delivery application. However, the relationship between physico-chemical parameters and bio-effects of silica nanoparticles is still unclear. In the present study, we investigated the effect of particle size on acute ...
Price Dwan D Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, Burwood, VIC 3125, Australia. ; NeuroAllergy Research Laboratory, School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, Geelong, VIC 3216, - - 2013
The increase in the incidence of food allergy is a growing problem for the western world. This review will focus on the findings from several macromolecular epithelial transport experiments and drug permeability studies to provide a recent comprehension of food allergen intestinal epithelial cell transport and the allergen-epithelial relationship. Specifically, ...
Koskimies Pasi - - 2013
Objective: To assess the effect of concomitant food intake on the relative bioavailability of ospemifene and its main metabolite, 4-hydroxyospemifene, after single oral dosing. Methods: This was an open-label, randomized, balanced, two-treatment (fed vs. fasted), two-period, two-sequence cross-over study in 24 healthy male subjects. Single 60-mg doses of ospemifene were ...
Lee Han-Seung - - 2013
Archaea are prokaryotic organisms distict from bacteria in the structural and molecular biological sense, and these microorganisms are known to mostly thrive at extreme environments. In particular, most studies on halophilic archaea have been focused on environmental and ecological researches. However, new species of halophilic archaea are being isolated and ...
Liu Z-Q - - 2013
B lymphocytes are an important cell population of the immune regulation; their role in the regulation of food allergy has not been fully understood yet. This study aims to investigate the role of a subpopulation of tolerogenic B cells (TolBC) in the generation of regulatory T cells (Treg) and in ...
Kannen Vinicius - - 2013
Calorie restriction regimens usually promote health and extend life-span in mammals. This is partially related to their preventive effects against malignancies. However, certain types of nutritional restriction failed to induce beneficial effects. The American Institute of Nutrition defines calorie restriction as diets which have only 40% fewer calories, but provide ...
Järvinen Kirsi M - - 2013
Children with food allergy have been shown to have increased small intestinal permeability (IP) following ingestion of the offending food as well as during elimination diets. We investigated IP in asymptomatic food allergic children during an elimination diet to identify clinical characteristics associated with altered IP. Urinary recovery ratios of ...
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