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Albert D J - - 1989
Female hooded rats were ovariectomized and implanted with a single testosterone-filled Silastic tube or an empty tube. The tube size was one which allowed a release of testosterone at the high end of the mean normal serum testosterone concentration for intact females. Following a 7-day recovery period, all rats were ...
McCarter R J - - 1989
It is widely held that restriction of food intake leads to a decrease in metabolic rate, and this effect has been implicated as the mechanism by which food restriction retards aging in laboratory rodents. Data on which this belief is based were obtained mostly from studies of basal metabolic rate ...
Laganiere S - - 1989
To assess which membrane properties are modulated by the action of food restriction, characteristics of liver membrane structures of ad libitum-fed and food restricted Fischer 344 rats were analyzed over a wide age range. The results show that the yields of mitochondrial and microsomal membranes decreased in ad libitum-fed rats, ...
Masoro E J - - 1989
Chronic nephropathy involving glomerular sclerosis markedly progresses in severity with age in male Fischer 344 rats fed ad libitum. Restricting food intake by 40% almost totally prevents progression of these lesions. Restricting food intake by 40% without restricting protein intake is also highly effective although somewhat less so than food ...
Rikimaru T - - 1989
Urinary excretions of creatinine (CR) and 3-methylhistidine (3-MeHis), and skeletal muscle mass (SKM) were measured in rats (male, Wistar, weighing about 290 g) fed a 20% casein diet ad libitum, rats restricted to 70% of the food intake of the ad libitum group, and rats deprived of food for 20 ...
Krackow S - - 1989
Primiparous, post-partum mated BALB/c bom inbred mice were allowed to raise litters of 6 young until Day 22 of lactation: 11 of 25 females were restricted to 60% of food consumption of ad-libitum fed dams after stud male removal at Day 2 of lactation. Since weight gain of restricted females ...
Rajpurohit R - - 1989
The susceptibility of experimental rats to Aflatoxin B1, a well known hepatocarcinogen, during chronic food restriction was studied, using a few putative preneoplastic biochemical markers. Gamma-Glutamyl transpeptidase was the most sensitive among the various enzymes studied, at the dose of 10 micrograms/day/100 gm body weight of Aflatoxin B1 fed over ...
Holliday R - - 1989
Calorie restriction results in an increased lifespan and reduced fecundity of rodents. In a natural environment the availability of food will vary greatly. It is suggested that Darwinian fitness will be increased if animals cease breeding during periods of food deprivation and invest saved resources in maintenance of the adult ...
Abraham M E - - 1989
The pattern of activity obtained in rats on a regimen of one hour access to food and water was compared to the activity pattern seen when immobilization stress was added to the same regimen. Food and water were provided at the same time of the day. Immobilization stress decreased the ...
Russell J C - - 1989
The JCR:LA-corpulent rat is a congenic strain that, if homozygous for the cp gene, is obese with a very low-density lipoprotein hyperlipidemia and is insulin resistant. The male corpulent rats develop atherosclerotic lesions of the major arteries and myocardial lesions. Corpulent and lean male rats were induced through mild food ...
Masoro E J - - 1989
Glucose has been proposed as a mediator of aging processes by means of glycation reactions resulting in advanced glycosylation end-products, thereby altering protein and DNA function. Testing this provocative concept has a high priority in gerontologic research. In this study, food restriction of rats--a procedure which markedly retards aging processes--was ...
Neafsey P J - - 1989
A Gompertz age-specific mortality rate model characterizing actuarial effects of food restriction in rats was developed based on mortality data from the study of Yu et al. (J. Gerontol. 40: 657-670, 1985). Results indicated that in the presence of adequate nutrition, food restriction reduces the aging rate parameter in a ...
Restrepo C - - 1989
The present work compares the effects of post-weaning crowding and those of food restriction on growth, body weight gain and the levels of several hormones, in male Sprague-Dawley rats. Crowding resulted in reduced food intake and diminished body weight gain. Rats daily receiving the same amount of food as that ...
Gross L - - 1988
Recent data referring to the influence of a restricted diet on the incidence of radiation-induced tumors and leukemia in rats and mice are reviewed. The incidence of tumors developing in rats exposed to total-body gamma irradiation was reduced from 93% to 35% in female rats and from 59% to 7% ...
Kalu D N - - 1988
Aging caused an increase in serum calcitonin that was markedly suppressed by food restriction. Food restriction had no significant effect on gut calcium absorption, urinary calcium excretion, serum 1,25(OH)2 vitamin D, blood ionized calcium, the clearance of calcitonin from plasma, and its rate of inactivation in vitro by the kidney ...
Touyz S W - - 1988
A 19-year-old woman, blind since birth, lost 26 kg over a 7-month period. This was achieved by restriction of food intake, excessive exercise, laxative abuse, and self-induced vomiting. Although the visual experience is often believed to be an integral component of body-shape perception and the overvaluation of thinness in contemporary ...
Alloway R - - 1988
Of twelve patients consecutively admitted to the Maudsley Hospital Eating Disorders Unit, four had neuromuscular abnormality, eight haematological abnormality, and four no abnormality. All those having neuromuscular signs had concomitant haematological dysfunction. Vomiting, and food restriction with vegetarianism, appeared more likely to lead to complications than either food restriction alone ...
Bernardis L L - - 1988
The present study was performed to see whether somatic and underlying metabolic-adaptive responses of DMNL rats and sham-operated controls (CON) to body weight restriction and subsequent refeeding could be influenced by the duration of ad lib feeding between lesion production and start of restriction. In contrast to previous studies (42 ...
Gettys T W - - 1988
1. Two experimental approaches were employed to assess the relation between food consumption rate and maintenance requirements in male weanling rats. The first approach involved restricting food intake in rats previously given free access to food from weaning to 59 d of age. The second approach involved restriction of food ...
Elsayed N M - - 1988
We fed Sprague-Dawley rats either freely or by restricting them to 20% of their usual diet for 21 days. In one experiment, we refed half of the food-restricted rats for 12 h, then exposed the three groups to air or 85% O2 for 5 days. The mortalities in 85% O2 ...
Bronson F H - - 1988
Female rats were prevented from growing and developing reproductively by restricting their food intake from the time they reached 80-85 g (27-29 days of age) until they were 2 mo old. A return to ad libitum feeding then typically yielded the pubertal ovulation during the third or fourth dark period. ...
Ward W F - - 1988
Age-related changes in liver protein synthesis of ad libitum fed and food-restricted SPF Fischer 344 rats have been measured. In ad libitum fed animals, valine incorporation increased from 3 to 6 mo of age, decreased to the 3-mo level at 12 mo, remained relatively constant through 18 mo, and then ...
Nelson W - - 1988
Evidence that food restriction alters circadian rhythms as it prolongs the healthful life of rats and mice is reviewed. Because rhythms in different variables are changed in different ways, the circadian organization that is characteristic of freely feeding animals is disrupted. In the case of daily food restriction (meal feeding), ...
Johnson D A - - 1988
Chronic administration of the catecholamine-depleting agent, reserpine (0.5 mg/kg), resulted in a reduction in food intake after 3 days. To differentiate effects of the drug from those of reduced food intake a pair-fed group, whose daily caloric intake was restricted to the amount consumed by the reserpine-treated rats, was included. ...
Hill J O - - 1988
Mature (450 g) rats were subjected to food restriction (60 percent of usual intake) with or without weight cycling (produced by cycles of 3 days of fasting followed by 7 days of refeeding). Weight cycling did not affect body weight, body composition, or food efficiency during the restriction period. However, ...
Källman S - - 1988
Field studies were undertaken to investigate if wild plants alone can be used as food to supply the necessary quantities of carbohydrates during survival and evasion. In these situations, attention must be drawn to the physiological effects of hypoglycemia and the proper utilisation of the adipose tissue as energy in ...
Shorey C D - - 1988
Morphometrical analyses were carried out on muscle fibres from cross-sectional areas of the medial head of gastrocnemius muscles from 5 groups each of 4 male Wistar rats representing young (aged approximately 100 days), medium-aged (400 days), old (1,000 days), old hypophysectomized (1,000 days) and old food-restricted (1,000 days) rats. Approximately ...
Hocking P M - - 1987
1. The phase of rapid development of ovarian follicles in turkeys fed ad libitum or given a restricted allocation of food from 6 to 30 weeks of age was determined by feeding a fat soluble dye and counting the number of rings of dye in the yolks of laid eggs. ...
Wyndham J R - - 1987
Age-related thickening of the glomerular basement membrane (GBM) was studied in three groups of male Wistar rats: (a) ad libitum fed, (b) hypophysectomized and (c) food-restricted eating the same amount of food as hypophysectomized rats, but about 45% of the ad libitum fed group. Studies were begun at 50 days ...
Bernier J F - - 1987
The effect of the level of food intake on protein synthesis rate in carcass, liver, gastrointestinal tract (GIT) and heart, kidneys and lungs (HKL) was determined in male mice with a major gene for rapid postweaning gain (line Ch) and normal controls (line CH) at 31 d of age. In ...
Marsteller F A - - 1987
Lactating HS/Ibg house mice housed at 21 degrees C and 5 degrees C were assigned to 3 feeding regimes: ad libitum, daily rations of 80% of ad libitum, or 60% of ad libitum beginning on the day that they bore litters. Significant interaction between temperature and food restriction was found ...
Bertrand H A - - 1987
The effects of aging and of food restriction at different times during life on rat adipocyte responses to glucagon and epinephrine were explored by studying hormone-stimulated lipolysis, hormone binding, and phosphodiesterase activity. The times of food restriction were: (a) from 6 weeks of age, (b) limited to early life, and ...
Pocino M - - 1987
We have studied the influence of different degrees of calorie restriction on the induction and the regulation of the delayed type hypersensitivity (DTH) response to trinitrobenzenesulfonic acid (TNBS) and TNBS-modified spleen cells (TNBS-SC), injected by the sc or the iv route. Immediately after weaning, BALB/c mice were placed on restricted ...
Thacker S V - - 1987
We investigated the effects of acute food deprivation on the rates of glucose metabolism and lactate production by epididymal fat cells isolated from 2- and 8-mo-old Wistar rats in one of three nutritional states: fed ad libitum, restricted to 50% of ad libitum, or fasted for 48 h. Food restriction ...
Whitehead C C - - 1987
1. Dwarf broiler breeders were either fed ad libitum or restricted to allow growth to mean body weights of 1.4 or 1.8 kg at 20 weeks of age. During the breeding period these birds were fed ad libitum, or food was restricted to different degrees and the birds subjected to ...
Preston A P - - 1987
1. Layers housed as pairs in cages were denied access to food from 07.30 to 15.30 h each day. Analyses of video records of daily activity patterns showed several behaviour changes compared with the patterns shown by similar birds allowed ad libitum (AL) access to food. 2. Birds given restricted ...
Ves Losada A - - 1987
Male rats maintained at 24 C and then shifted to 5 C for 5 days increased food intake and decreased in growth rate and food conversion. No modification was observed in delta 6 desaturase activity, while delta 9 desaturase activity decreased after this period of time. These results were confirmed ...
Pugliese M T - - 1987
Parental misconceptions and health beliefs concerning what constitutes a normal diet for infants is reported as a cause for failure to thrive. There were seven patients (four boys, three girls), 7 to 22 months of age, who were evaluated for poor weight gain and linear growth. They were only consuming ...
Pinchasov Y - - 1987
The relationship between water intake and water concentration in the body and in the gastrointestinal contents was studied in meat-type chickens fed either intermittently or ad libitum, as controls. In experiment 1, male broilers were reared from 12 to 33 d of age and were fed every second day or ...
Totter J R - - 1987
Beneficial (hormetic) effects of ionizing radiation have been largely ignored in developing radiobiological theory, chiefly because a suitable explanatory hypothesis is lacking. Examination of the relevant literature has revealed that food restriction effects in animals resemble those of low-level, low-LET, whole-body ionizing radiation exposure (without food restriction) in two major ...
Rehm S - - 1987
A life span study of 900 female virgin Han:NMRI mice (300 outbred controls, 300 of a fat subline, and 300 of a lean subline) was done to determine the occurrence of spontaneous disease with ad libitum or restricted feeding. Major nonneoplastic lesions in the glandular stomach were erosions, ulcers and ...
Azoulay-Dupuis E - - 1987
The effects of food restriction or 20 ppm NO2 exposure on humoral immunity were investigated in normal and adrenalectomized C57Bl/6 mice. The thymic and splenic weights of sham-operated mice were similarly diminished after 4 days of NO2 exposure or 4 days of food depletion. The responses of corresponding adrenalectomized mice ...
Harrison D E - - 1987
Lifelong food restriction to two-thirds of normal ad libitum consumption extended mean and maximum life spans more than 200 d in male B6CBAF1 hybrid mice, already a long-lived genotype. The following biological systems were improved by food restriction, with values for older mice being similar to those previously found for ...
Cleary M P - - 1987
The effects of long-term moderate food restriction were assessed in lean and obese male Zucker rats. A 30% reduction in food intake from 5 to 68 wk of age resulted in parallel lowering of body weight in both lean and obese rats compared to their respective ad libitum-fed control groups. ...
Woodside B - - 1987
The ability of rat dams to cope with food restriction as well as a concurrent lactation and pregnancy was examined by varying the duration, time of onset and severity of the food restriction schedule. Groups of females impregnated in the postpartum estrus and nursing 8 pups were either allowed to ...
Armario A - - 1987
Adult male Sprague-Dawley rats were subjected to food restriction so that they ate 65% of food ingested by control rats. While control rats had free access to food over the 24-hour period, food-restricted rats were provided with food daily at 10 a.m. The experimental period lasted for 34 days. On ...
Puerta M L - - 1987
Food intake, body weight and brown adipose tissue (BAT) mass and composition of rats exposed at 6 degrees C either with food ad libitum or food-restricted were compared with those of rats in the thermoneutral zone, with food ad libitum. Cold acclimation with food ad libitum increases food intake and ...
Luz J - - 1987
The objective of the present study was to determine the relative importance of thermoregulatory and energy conservation mechanisms in cold-exposed, food-restricted rats at thermoneutrality. Oxygen consumption was measured at 25 degrees C and 10 degrees C in rats acclimated at 30 degrees C and fed ad libitum and in animals ...
Hill J O - - 1987
To investigate whether intermittent fasting alters subsequent utilization of ingested energy, we compared, in six groups of 450-g male Wistar rats, two modalities of food delivery: constant (CO) vs fasting for 3 days and refeeding for 7 days (F/RF). Both modalities were investigated at three planes of nutrition (100, 60 ...
Nelson R J - - 1987
The role of the pineal gland in mediating reproductive regression in response to nonphotoperiodic cues was assessed. A proportion of deer mice (Peromyscus maniculatus) undergo gonadal regression subsequent to moderate food restriction. The reproductive regression after inanition qualitatively and quantitatively resembles short-day-induced regression. The physiological mechanisms responsible for gonadal regression ...
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