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Abrahamsen G C GC Millhauser Laboratories, Department of Psychiatry, New York University Medical Center, NY 10016, - - 1995
Chronic food restriction lowers the threshold for lateral hypothalamic electrical self-stimulation (LHSS). This effect has previously been interpreted to reflect a sensitization of reward. In the present study a curve-shift method was used to explicitly differentiate effects of food restriction on brain stimulation rewarding efficacy and performance. Food restriction consistently ...
Portha B - - 1995
It has been suggested that impaired insulin action and/or insulin secretion in adult mammals could be a consequence of severe food restriction during fetal life. We have determined to what extent glucose homeostasis and insulin action are modified in male offspring of rats undernourished only during the first two trimesters ...
Urao M - - 1995
To investigate the beneficial effects of food restriction on systemic lupus erythematosus in NZB x NZW F1 mice, we separated the mice into three groups. One was fed a diet in which total food intake was reduced to 60% of normal from age 2 mo onward, while the animals were ...
McGuire M K - - 1995
This study was designed to determine if nutrient availability during gestation and early life modifies the effects of subsequent dietary intake on reproductive and lactation performance. Rat pups, whose mothers had been allowed free access to food or were food-restricted to 50% of ad libitum consumption were assigned to free ...
Luz J - - 1995
Data from our laboratory have demonstrated that food restriction leads to alterations in energy balance such as reduced energy expenditure as an energy conservation mechanism. Food restriction may be imposed on the animals in different ways. The most common is to give equal daily amounts of restricted food. Alternatively, food ...
Walker C D - - 1995
It has been shown that restricting food in lactating rats for the first 2 weeks postpartum at a level of 60% of the ad-libitum daily ration increases the length of lactational dioestrus by about 7 days but little is known about correlated changes in hormone levels. In the first experiment ...
Boswell T - - 1995
The present study addresses the role of prolactin as a regulator of migratory fattening in European quail (Coturnix coturnix). Plasma prolactin levels in captive birds undergoing migratory fattening in an outdoor aviary and in the laboratory were measured by radioimmunoassay with an antibody raised against recombinant-derived chicken prolactin. No strong ...
Thurman J D - - 1995
Two of 632 Fischer-344 rats in a food restriction study had spontaneous, bilateral, multicentric renal tubular cell carcinomas. Although there were 104 litters represented in this study, both rats that developed this rare neoplasm were from the same litter. The littermates, one male and one female, were in the food-restricted ...
Qu W - - 1995
Rates of conjugation of p-nitrophenol were studied in livers from normal and food-restricted rats perfused with either p-nitroanisole or p-nitrophenol. Female Sprague-Dawley rats had ad libitum access to a Purina 5001 nonpurified diet (control) or were given 65% of the intake of controls for 3 weeks. Livers were perfused with ...
Lane M A - - 1995
Food restriction increases life span, reduces aging rate and affects a wide variety of biological functions. In rats, food restriction delays bone growth and reduces bone density and mineral content. We report the effects of aging and long-term (> 6.0 y) food restriction on several indices of bone growth and ...
Jones G P - - 1995
1. Broilers were fed ad libitum or early-life food restricted and grown to 42 d of age to determine the influence of food restriction on the incidence and occurrence of ascites. 2. No differences in body weight, food conversion efficiency or arterial pressure index were observed although haematological data indicated ...
Hall M D - - 1995
The effect of post-operative diet selection on the recovery rate of 100 children ages 3-17 years undergoing tonsillectomy and adenoidectomy (T & A) was studied. In the first 12 h after T & A children were allowed either a 'restricted' diet of only soft foods and liquids or a 'non-restricted' ...
Kaufman A R - - 1995
Fifteen female ICR mice, 6-8 weeks old, were each exposed to 25 metacercarial cysts of Echinostoma caproni. To determine the effects of withholding food on survival, size and distribution of E. caproni in ICR mice, two groups of five each were maintained without food for 1 day (group A) or ...
Byun D S - - 1995
Food restriction delays the loss of several cellular immune functions, retards the onset of many diseases during aging and, consequently, extends life span significantly in laboratory rodents. The present study was undertaken to determine whether the age-associated loss in immune function is linked to changes in microsomal and mitochondrial membranes ...
Xia E - - 1995
The objective of this study was to determine how food restriction (40% restriction of food intake) altered the age-related changes in the activities of Cu,Zn superoxide dismutase, catalase and glutathione peroxidase in liver, brain cortex, heart, kidney and intestinal mucosa obtained from 6-, 16- and 26-mo-old male Fischer 344 rats. ...
Conn C A - - 1995
Acute aerobic exercise has been shown to elicit physiological changes characteristic of the acute phase response (APR), a nonspecific host defense response. Regular evocation of these changes may prime the immune system to improve resistance to disease. Because food deprivation is associated with an impaired APR, food restriction may prevent ...
Conn C A - - 1995
We tested the hypothesis that voluntary running and moderate food restriction alter the acute phase response (APR), one index of nonspecific immune function. Hamsters were kept sedentary or permitted to run and were fed ad libitum or had food restricted for 20 days and were then injected intraperitoneally with saline ...
Everitt A V - - 1995
Long-term food restriction is known to inhibit development and aging in the rat. These actions may be mediated by the pineal hormone, melatonin, whose secretion is increased by food restriction. This mechanism was investigated by studying the effects of pinealectomy in ad libitum fed and food restricted rats of both ...
Bollweg G - - 1995
GM1 ganglioside (one week each at 10, 5, and 2.5 mg GM1/kg per day, ip) or gradual food restriction leading to a reduction in body weight to 75% of control were tested for their ability to block or reverse histopathologic and behavioral effects of trimethyltin (TMT) poisoning in rats. TMT ...
Wennerholm K - - 1995
The effect of sugar restriction on the oral levels of mutans streptococci was studied in 20 subjects fulfilling three criteria: (1) having more than 300,000 CFU mutans streptococci/ml saliva, (2) harbouring both Streptococcus mutans and Streptococcus sobrinus in saliva, and (3) eating sugar frequently. The subjects were randomly divided into ...
Masoro E J - - 1995
Long-term dietary restriction programs which retard aging processes in rodents usually involve meal eating rather than the nibbling pattern of food intake of ad libitum fed rodents. Thus, the possibility arises that the antiaging action may at least in part result from an altered temporal pattern of food intake. This ...
Merkt J R - - 1994
Food, like water, is in short supply in the desert. We report a specialized mechanism used by a desert mouse for surviving prolonged food shortages. The key element of this adaptation is a large reduction in resting metabolism. After about 2 weeks of restricted food intake (50% of normal), the ...
Sugden M C - - 1994
The effects of food restriction (limited access to food for 2 h/day for 10 days) on lipoprotein lipase (LPL) activities and rates of fatty acid synthesis and glucose utilization in vivo in two superficial (interscapular and subcutaneous) and three deep abdominal white adipose tissue depots (parametrial, perirenal, and mesenteric) of ...
Berman Y - - 1994
Chronic food restriction produces a variety of physiological and behavioral adaptations including a potentiation of the reinforcing effect of food, drugs and lateral hypothalamic electrical stimulation. Previous work in this laboratory has revealed that the lowering of self-stimulation threshold by food restriction is reduced by mu- and kappa-selective opioid antagonists. ...
Grasl-Kraupp B - - 1994
Restriction of dietary calories reduces cancer formation in experimental animals and probably also in humans. This effect is generally attributed to the inhibitory effect of fasting on cell proliferation. Here we studied the effect of fasting on physiological cell death through apoptosis by using rat liver as a model. (i) ...
Hazlett B A - - 1994
Three species of crayfish (Orconectes virilis, O. rusticus, andCambarus robustus) were tested for feeding responses to potential food odors from mollusks (either zebra mussels,Dreissena polymorpha, or native gastropods). In all three crayfish species, feeding responses to odor cues were shown only by individuals experienced with feeding on a prey type. ...
Qu W - - 1994
This study assessed the effect of food restriction on the metabolism of model monooxygenase substrates in the perfused rat liver. Female Sprague-Dawley rats has access ad lib. to a Purina 5001 nonpurified diet (control) or were given 65% of the intake of controls for 3 weeks. Livers were perfused with ...
Hocking P M - - 1994
The general and sexual activity of food restricted male broiler breeder poultry was assessed for evidence of behavioural changes associated with musculoskeletal lesions. The activity and fertility of male birds given betamethasone (an anti-inflammatory steroid) or saline were compared in a two-period crossover experiment. Behavioural changes occurred and the birds' ...
Cameron-Smith D - - 1994
Hyperglycemia has been shown to contribute to the development and maintenance of insulin resistance in diabetic subjects and animal models of diabetes. Normalisation of circulating glucose levels is effective in restoring insulin action. The aim of the current study was to investigate the effects of mild food restriction on hyperglycemia ...
Zulkifli I - - 1994
1. White Plymouth Rock chickens placed under 60% food restriction or ad libitum feeding, with or without metyrapone treatment, from either 4 to 6 (early) or 24 to 26 (late) d of age were exposed to high ambient temperatures (35 +/- 2 degrees C) from 36 to 43 d of ...
Driver C J - - 1994
It is proposed that aging is induced by somatic replication of transposable elements (TEs). Most transposable elements in Drosophila reproduce by reverse transcription. Therefore inhibitors of reverse transcriptase were tested for their ability to retard aging in Drosophila melanogaster. Two inhibitors, phosphonoformic acid (PFA) and dideoxyinosine (ddI), were capable of ...
Pieper D R - - 1994
Previous studies have shown that bilateral removal of the olfactory bulbs (BX) results in a large increase in gonadotropin secretion in golden hamsters. The principal question addressed by the present study was whether BX would offset the inhibitory effect of food restriction on reproductive function. BX or sham (SH) BX ...
Zulkifli I - - 1994
1. Dwarf and nondwarf chickens placed under 60% food restriction from either 4 to 6 (early) or 24 to 26 (late) days of age were exposed to high ambient temperatures (35 +/- 2 degrees C) from 36 to 43 d of age. 2. As measured by heterophil/lymphocyte (H/L) ratios, stress ...
Carr K D KD Millhauser Laboratories, Department of Psychiatry, New York University Medical Center, New York - - 1994
Chronic food restriction and weight loss were previously shown to produce a naltrexone-reversible facilitation of perifornical lateral hypothalamic self-stimulation. In the present study, high affinity receptor-selective antagonists were used to determine the particular opioid receptor type(s) that mediates the facilitation of reward by food restriction. Separate groups of food-restricted and ...
García-Belenguer S - - 1993
After 4 weeks of food restriction to 50% of ad libitum intake in rats, plasma corticosterone levels were increased, without any change in adrenal weight, and with no evidence of sympathetic nervous system activation (as measured by Tyrosine Hydroxylase and Phenylethanolamine N-Methyl Transferase activities in the adrenal gland). Plasma corticosterone ...
Saari J T - - 1993
To test the effect of food restriction on responses to dietary copper deficiency, male weanling rats were fed two amounts of dietary copper via five dietary-intake regimens ranging from ad libitum to 70% of ad libitum intake. Copper-deficient rats exhibited characteristic signs, including depressed organ copper content, reduced activity of ...
Sugden M C - - 1993
The present study investigated the effects of chronic food restriction (achieved by limiting access to food to 2 h daily for up to 8 weeks) on the activity of the active form of pyruvate dehydrogenase (PDHa) in liver. Accelerated and exaggerated activation of hepatic PDH in response to a meal, ...
Hammond P B - - 1993
The overall objective of this investigation was to determine whether the growth-depressive effects of lead (Pb) are reversible. The animal model used was the female weanling rat. In Study 1, one group of animals was exposed to Pb for 10 days, a second group was exposed for an additional 21 ...
Ruf T - - 1993
We investigated the influence of ambient temperature (Ta) and food availability on seasonal timing and extent of physiological responses to short photoperiod (SP), in particular daily torpor, in Djungarian hamsters (Phodopus sungorus). Exposure of hamsters to cold temperature (Ta = 5 degrees C), relative to warm Ta (23 degrees C), ...
Bates P C - - 1993
Hypophysectomy of adult rats results in a loss of body growth which can be reversed by treatment with GH. The increased growth caused by administration of GH is accompanied by an increase in food consumption. The effects of GH and interactions with nutrition were investigated by treating hypophysectomized rats with ...
Salih M A - - 1993
Male F344 rats fed ad libitum or maintained on 60% of the ad libitum food intake were sacrificed at 6, 12, 18 and 24 months of age. The thyroids were removed for the analysis of the C-cell hormones, calcitonin, calcitonin gene-related peptide (CGRP) and somatostatin. In the animals fed ad ...
Dong Q - - 1993
The effect of food restriction on circulating luteinizing hormone (LH) levels in orchidectomized rats is controversial. The present study demonstrates that decreasing food intake by 50% for 3-10 days in orchidectomized rats increases LH pulse amplitude, length, area under pulse curve, and mean levels but decreases LH pulse frequency compared ...
Ghooi R B - - 1993
Salt has had a long and controversial history. It is not known when man began to use salt in his diet, but it is logical to believe that salt has always been a part of human diet though we do not have scientific proof for this. Restriction of salt in ...
Munch I C - - 1993
Oxygen consumption was measured in male rats during starvation and during different regimens of restricted feeding and refeeding after starvation. Changes in oxygen consumption and body mass were mostly parallel, but rats with a very reduced food intake displayed the same reduction in oxygen consumption as starved rats, despite the ...
Deroche V - - 1993
Food restriction has been shown to enhance the behavioral sensitivity to addictive drugs. The biological factors involved in this effect are largely unknown. Since food restriction, among other factors, increases corticosterone secretion, the role of this hormone in the effects of food restriction on the response to psychostimulants and opioids ...
Reif S - - 1993
Fibrosis of the liver has been reported to be associated with malnutrition, based on qualitative histological and histochemical approaches. The aim of this study was to quantitatively examine the effect of perinatal food-restriction on the expression of extracellular matrix components of the liver, using rats fed 50% of ad libitum ...
Carr K D - - 1993
Electrical stimulation frequency thresholds for lateral hypothalamic (LH) self-stimulation were monitored throughout a 3 week period of food restriction and a subsequent 3 week period of re-feeding. Rats with electrodes placed in the perifornical LH were sensitive to this dietary manipulation as evidenced by a high positive correlation between body ...
Wideman C H - - 1993
Plasma levels of glucose and urea nitrogen were compared in vasopressin-containing (LE) and vasopressin-deficient (DI) rats under ad lib and food-restricted conditions. In the ad lib situation, DI and LE rats had similar levels of glucose and urea nitrogen. Variations in this pattern were observed under food-restricted conditions. The DI ...
Kelly F J - - 1993
In ad lib.-fed rats the epithelium of the small intestine, like the liver, contains large quantities of glutathione, 17.0 and 32.4 nmol/mg protein respectively. Following 24 h food restriction the glutathione content in both tissues fell 53 and 69% respectively. Unlike the liver, however, the glutathione content of the intestinal ...
Mistlberger R E - - 1993
Wheel-running activity of 31 Syrian hamsters was monitored in constant light (LL), dark (DD), and light-dark (LD) under ad lib and restricted food and water access schedules. Free-running or damped circadian wheel-running rhythms of 26 hamsters in LL were entrained by exposure to the restriction schedule. The phase of entrainment ...
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