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Results 301 - 350 of 550
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Lieverse R J - - 1993
CCK-33 was infused intravenously to groups of 9 lean and 9 obese volunteers in doses that elicited plasma CCK concentrations in the physiological range. The effect of these infusions on food intake and satiety signals was compared with the effect of saline infusions in the same subjects. Food intake (486 ...
Delany H M - - 1993
Access to the jejunum by orogastric intubation or insertion of a surgical tube provides a method for nutrient infusion in clinical conditions that involve abnormal upper gastrointestinal function. Despite the physiologically extraordinary nature of jejunostomy intubation-with enteral infusions beyond the stomach, biliary tract, pancreas, and duodenum--the current view is that ...
Balaskas E V - - 1993
We studied the effect of intraperitoneal infusion of various volumes and concentrations of dextrose (D) and amino acid (AA) solutions, in a variety of peritoneal dialysis schedules on food intake and biochemical profile in normal and uremic rabbits. Following omentectomy, a peritoneal catheter was implanted. Animals had free access to ...
Huang Y S - - 1993
Effects of cholecystokinin octapeptide (CCK-8) on feeding behavior were examined in male and female rats. After an 18-hour fast, ad lib food intake for 30 minutes was measured for each rat. In male rats, food intake measured for 30 minutes was significantly decreased by intraperitoneal injection of 0.25 to 1 ...
Yoshimatsu H - - 1992
The effects of injecting cholecystokinin (CCK) into the third ventricle or into selected hypothalamic sites on electrical firing rate of sympathetic nerves to interscapular brown fat (IBAT) has been investigated in anesthetized rats. The hypothesis for these experiments was that there was a reciprocal relationship between sympathetic activity and food ...
South E H - - 1992
Systemic administration of cholecystokinin C-terminal octapeptide (CCK-8) decreases body temperature. However, it remains unclear whether reduction of body temperature is concomitant with suppression of food intake at CCK-8 doses that approach physiological levels. We examined rectal temperature after intraperitoneal CCK-8, 4 micrograms/kg, both in the presence and absence of a ...
Melville L D - - 1992
3S(-)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-yl) -1H-indole-2-carboxamide (devazepide), a potent and selective cholecystokininA (CCKA) antagonist, has been shown to reverse the inhibitory effect of exogenously administered CCK-8 on food intake. In all tests, however, the inhibition of food intake could have been due not only to the CCK-8 administered but also to synergistic interactions between ...
Calingasan N - - 1992
Exogenous cholecystokinin (CCK) suppresses food intake by acting on vagal sensory neurons. However, CCK doses used in behavioral experiments are generally much larger than those necessary to produce electrophysiological changes in vagal afferents. We made automated measurements of liquid food intake before, during, and after infusion of low doses of ...
Okabe Y - - 1992
To ascertain anorexigenic effect of toxohormone-L, a polypeptide extracted and purified from ascites of patients with hepatoma were infused into the rat third cerebroventricle. Food intake decreased on the first day after infusion of an optimum dose of 10.0 micrograms (p less than 0.05). The suppressive effect on feeding was ...
Flanagan L M - - 1992
Systemic administration of cholecystokinin (CCK) or LiCl inhibits gastric motility and food intake in rats. Brain stem-projecting oxytocin (OT) neurons in the hypothalamic paraventricular nucleus (PVN) have been proposed to mediate the inhibitory effects of CCK and LiCl on gastric motility and food intake. In the present studies, we found ...
Geracioti T D TD - - 1992
Six patients with anorexia nervosa, the same patients after weight normalization, and six healthy control subjects had similar fasting and postprandial plasma cholecystokinin concentrations. These data do not support the hypothesis that low levels of hunger and food intake in anorexic patients reflect hypersecretion of this endogenous hormone, which is ...
Hildebrand P - - 1992
Somatostatin 28 (S-28), originating in gastrointestinal cells, is secreted into the circulation and increases in humans after ingestion of a mixed meal. To evaluate the possibility that the increased levels of S-28 post cibum might modulate the release of enzymes and bicarbonate from the exocrine pancreas, S-28 was infused intravenously ...
Denbow D M - - 1992
Triacylglycerols of varying chain lengths were tested for their effects on food intake in fasted Single-Comb White Leghorn cockerels 9-12 weeks of age. Tributyrin, tricaprylin, triolein, or saline were intubated intragastrically or infused intrahepatically. All triacylglycerol administrations were in 10 ml volumes with 10 kcal being infused intrahepatically and 10 ...
Deutsch J A - - 1992
The effect of treatment with the cholecystokinin antagonist L364,718 on intake of different dilutions of corn oil emulsion was tested under two levels of familiarity with the oil emulsion. No increase in intake was observed. To see if the CCK antagonist was effective under our conditions, exogenous CCK was administered ...
Laferrère B - - 1992
To study the mechanism by which bombesin induces satiety, we studied the effect of two new peptides, BIM187, a bombesin agonist, and BIM189, a bombesin antagonist, on food intake in rats fed 6 h a day. BIM187 at 4 micrograms/kg, significantly reduced food intake at 30 min, but did not ...
Azahan E A - - 1992
Infusion of salts of short-chain fatty acids into the rumen of sheep depresses food intake but the relative importance of the effect of the acids and of osmolality are not fully understood. Three experiments were carried out in which sodium acetate (NaAc) and sodium chloride (NaCl) were infused for 3 ...
Walls E K - - 1992
Three types of nutrient were infused intravenously for 30 min before and during the 17 h when rats were fed to assess the effects of these nutrients on short-term and daily food intake. Infusions of glucose (34 kcal/day for 4 days) reduced food intake from saline baseline levels by 18.8 ...
Miesner J - - 1992
To test the hypothesis that endogenous cholecystokinin (CCK) released from the small intestine by ingested food produces a satiating effect by acting at CCKA-receptors, we measured the effect of slow continuous intravenous infusions of three doses of MK-329, a potent and selective CCKA-antagonist, on food intake during 2.5-h tests in ...
Moran T H - - 1992
The relative ability of a norleucine substituted cholecystokinin (CCK) analogue, U-67827E, to interact with CCK receptors and to inhibit food intake was examined across a variety of paradigms. U-67827E and CCK had identical in vitro potencies as demonstrated by their ability to induce pyloric contractions or competitively inhibit [125I]CCK-8 binding ...
Schick R R - - 1991
In man, only little is known about the site of origin of satiety signals within the gastrointestinal tract. Therefore, it was the aim of this study to examine the role of the stomach and the small intestine as a source of satiety signals. 8 overnight fasted healthy volunteers received intraduodenal ...
Laferrere B - - 1991
The role of cholecystokinin (CCK) in food intake was investigated in rats by using BIM-18216, a novel CCK receptor antagonist. In rats fed 6 hr/day, BIM-18216 antagonized the reduction of food intake induced by exogenous CCK octapeptide (CCK-8; 4 micrograms/kg) in a dose-dependent manner and had a maximum effect at ...
Stricker E M - - 1991
Hunger and satiety appear to reflect the postabsorptive and absorptive phases of caloric homeostasis, respectively. However, only some of the signals that inhibit food intake can be related to caloric homeostasis. For example, decreases in food intake also are observed after administration of nauseogenic chemical agents, treatment with cholecystokinin (CCK), ...
Sasaki K - - 1991
In the present study, the relations between acidic and basic fibroblast growth factors (aFGF and bFGF, respectively), platelet-derived growth factor (PDGF), and food intake were studied. When aFGF-, bFGF-, and PDGF-like activity in cerebrospinal fluid (CSF) was examined by bioassay, the activity of those factors significantly increased in postfeeding CSF, ...
Tordoff M G - - 1991
We determined the site at which the fructose analogue 2,5-anhydro-D-mannitol (2,5-AM) acts to increase food intake in rats. Rats began eating sooner and ate more food during hepatic portal than during jugular infusions of 2,5-AM (50, 100, or 150 mg/h). After rats were intubated with 2,5-[14C]AM (1.15 microCi in 200 ...
Walls E K - - 1991
To determine whether feeding-generated gut signals act in conjunction with intravenous nutrients to suppress food intake, nutrients were infused intravenously to dark-fed rats during different portions of the 12:12 h light-dark cycle. During 4-day test periods rats received 35.5-37 kcal/day of a solution containing 25% glucose-4.25% amino acids. Food intakes ...
Reuss S - - 1991
The immunocytochemical distribution of the putative satiety peptides bombesin (BBS) and cholecystokinin (CCK) were studied in the hypothalamic suprachiasmatic nuclei (SCN) of male and female Djungarian hamsters (Phodopus sungorus) held under either long (light/dark, LD 16:8 h) or short (LD 8:16) photoperiod. The animals were killed by perfusion with a ...
Corwin R L - - 1991
To assess the role of cholecystokinin (CCK) receptors in mediating the satiating effect of an oral preload, overnight food-deprived rats (n = 7) were given access to a high-carbohydrate liquid diet for 40 min. At the end of 40 min, food was removed and rats were injected subcutaneously (SC) with ...
Muurahainen N E - - 1991
Cholecystokinin octapeptide (CCK-8) or saline was intravenously infused for 5 min before and 5 min during a meal of macaroni and beef, served 20 min after a preload of either 100 or 500 g of soup to 12 nonobese men. Intake of the test meal was significantly lower when CCK-8 ...
Rogers P J - - 1991
It was reported previously that the dipeptide sweetener aspartame suppresses food intake in humans by a postingestive action. The present study examined the hypothesis that this is due to an effect of phenylalanine, one of the primary breakdown products of aspartame (phenylalanine is a potent releaser of the so-called satiety ...
Pekas J C - - 1991
It was previously reported that cholecystokinin (CCK) immunization of swine increased food intake 8.2% and rate of growth 10.6%. This report compares carcass yields of lean, fat and bone tissues of CCK-immunized vs. human serum globulin (hSG) control animals. The experiment involved 24 castrated pigs, age 75 d, weight 25.6 ...
Kanayama S - - 1991
Dietary stimulation has trophic effects on the gastrointestinal tract, whereas prolonged fasting causes mucosal atrophy. Whether gastrointestinal endocrine cells within the mucosa are similarly affected is unknown. The present study was designed to determine the effects of food deprivation and refeeding on cholecystokinin (CCK) and somatostatin in the rat small ...
Tarjan E - - 1991
Sodium and water intake and excretion of wild rabbits was studied during intracerebroventricular (icv) infusion of corticotropin-releasing factor (CRF). Icv infusion of 200 and 600 pmol/h for 22 h induced changes in the ingestive and general behavior of animals. Increased consumption of 0.5 M NaCl solution was observed during the ...
Schick R R - - 1991
The present study was designed to determine in humans the dose of CCK which suppresses food intake. 18 male subjects received in randomized order either i.v. saline or Thr28 Nle31 CCK 25-33 (CCK-9) at 100 or 500 pmol/kgh, respectively. In addition, 7 subjects received CCK together with the opiate receptor ...
Bobbert A C - - 1991
Long-term records of the number of food approaches per 30 min were obtained from 16 rabbits in constant light and after blinding. Optic nerve sectioning usually resulted in a shortening of the free-running period (tau; mean reduction = -0.26 hr) of the oscillator governing the rabbit's food intake pattern. Subsequent ...
Tarjan E - - 1991
Intracerebroventricular (ICV) infusion of CRF, for 22 h, induced five- to seven-fold increase in the daily intake of sodium chloride solution in wild rabbits. The increased sodium intake persisted for 3 days after the infusion stopped and was accompanied by increased sodium excretion, water turnover and decreased food intake. ICV ...
Plata-Salamán C R - - 1991
From the perspective presented in this minireview, it is clear that a variety of psychological and physiological factors interact to regulate feeding behavior. The hunger-satiety cycle involves preabsorptive and postabsorptive humoral and neuronal mechanisms. Psychological, social and environmental factors, nutrients and metabolical processes and gastric contractions originate hunger signals. Eating, ...
Pérez C - - 1991
The present study investigated whether cholecystokinin (CCK), an intestinal hormone that is a putative satiety agent, can condition flavor preference in rats. In experiment 1 food-deprived rats were trained to consume two different-flavored saccharin solutions in separate one-bottle tests. One flavor (the CS+) was paired with intraperitoneal injections of CCK ...
Mathur R - - 1991
1. The development of endogenous cholecystokinin (CCK) effects on food intake was studied in normal and undernourished growing rats of postnatal day 1-22. 2. Food intake was estimated by recording the gain in body weight before weaning. 3. l-phenylalanine, a potent stimulant of endogenous CCK release, suppressed 30 min food ...
Lindén A - - 1990
In food-deprived male rats IP injection of cholecystokinin octapeptide (CCK-8, 5 micrograms), ingestion of food or ejaculation caused a comparable increase in plasma concentrations of CCK-8 and inhibited food intake. IV injection of 0.1 microgram CCK-8 interrupted ongoing feeding and greatly increased plasma CCK-8 levels. Osmotic minipumps delivering 0.5 micrograms ...
Takaki A - - 1990
Glutaryl-CCK-8 (Glt-CCK-8, 16-160 pmol) suppressed food intake dose dependently when injected into the ventromedial hypothalamus (VMH) bilaterally, but not when injected unilaterally. In contrast, CCK-8 (160 and 320 pmol) did not suppress food intake when injected into the VMH bilaterally. When injected intraperitoneally, Glt-CCK-8 significantly decreased food intake at a ...
Bellinger L L - - 1990
Preabsorptive satiety has been hypothesized to occur as the result of food activating oral and gastrointestinal receptors that cause the release of catecholamines in the liver. The catecholamines were then proposed to hyperpolarize hepatic glucoreceptors and produce satiety. In the present study the hepatic portal vein was chronically cannulated in ...
Alemayehu A - - 1990
The effects of a thromboxane A2 (TxA2)-endoperoxide receptor antagonist, SQ 29548, on jejunal blood flow, oxygen uptake, and capillary filtration coefficient (Kfc) were determined in anesthetized dogs under resting conditions and during the presence of predigested food in the jejunal lumen in three series of experiments. In series 1, 2.0 ...
Gil K M - - 1990
The effect of peripheral parenteral nutrition (PPN) on voluntary food intake was examined in healthy male subjects. Each study (lasting 17 to 19 days) was divided into three phases: Ringer's lactate (RL); PPN administered as a combination of glucose, fat, and amino acids; and finally RL. During the middle phase, ...
Koopmans H S - - 1990
Studies on animals that drastically reduce their food intake after having a jejunoileal bypass or an ileal transposition surgery suggest that the lower ileum may play a major role in the control of daily food intake. In this study, eight rats were given slow continuous infusions of either 18, 28, ...
Pekas J C - - 1990
Experimental superalimentation at 30% above ad libitum intake increased growth 40% and confirmed that voluntary food intake is a growth-limiting factor in swine. A sequence of contingent hypotheses was proposed for swine: cholecystokinin (CCK) is a regulator of food intake; food intake is enhanced by reduction of serum CCK; serum ...
Kaplan J M - - 1990
A novel intake testing paradigm, allowing explicit adjustment of the rate of sucrose ingestion via intraoral delivery, was used to investigate the effects of ingestion rate on ingestion duration and amount consumed. In experiment I, 12 rats were tested under each of three sucrose concentrations (0.1, 0.3, and 1.0 M) ...
Sawmiller D R - - 1990
If adenosine mediates postprandial intestinal hyperemia, increases in local adenosine release must accompany the hyperemia. We tested this by determining jejunal venous and arterial plasma adenosine concentrations, jejunal blood flow, and oxygen consumption before and during placement of normal saline or predigested food plus bile into the jejunal lumen of ...
McCoy J G - - 1990
The effects of injections of either bombesin (BBS) or cholecystokinin octapeptide (CCK-8) on patterns of food intake of macronutrients were examined in adult male rats, and compared to the effects following saline injections. The animals were food deprived for 18 hours and then offered one of three isocaloric dietary components ...
Badgaiyan R D - - 1990
The pH of third ventricular CSF was altered by infusing acidic or alkaline solution of artificial cerebrospinal fluid (aCSF) through chronically implanted stainless steel cannula. In two separate group of rats (n = 18 each) water and food consumptions were recorded 30 min, 1 hr, and 24 hr after intraventricular ...
Toth P - - 1990
The putative satiety peptide cholecystokinin octapeptide (CCK-8) has been shown to reduce ethanol intake induced by prior fluid deprivation. Since fluid-deprived animals tend to reduce their food intake and consequently become hungry, the ability of CCK-8 to reduce ethanol intake might be limited to conditions where the motivation for food ...
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