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Results 451 - 500 of 549
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Telegdy G - - 1984
The effects of intraperitoneally (ip.) and intracerebroventricularly (icv.) administered sulfated and nonsulfated cholecystokinin octapeptide (CCK-8-SE and CCK-8-NS) and their N- and C-terminal fragments on the tail-pinch-induced feeding behavior of rats were investigated. After ip. administration, only CCK-8-SE inhibited tail-pinch-induced food intake. After icv. administration, both CCK-8-SE and CCK-8-NS, in doses ...
Shurlock T G - - 1984
The hepatic portal veins of cockerels were catheterised to study the effects of 3-h infusions of nutrient solutions on voluntary food intake. An amino acid mixture, infused at rates up to 800 mg N/3 h, depressed intake of a standard diet in a significant linear manner (intakes with the highest ...
Levine A S - - 1984
Although the incidence of obesity in the domesticated dog is high, few studies have investigated the regulation of food intake in this species. In the present study we investigated the response of the dog to a number of putative satiety agents including cholecystokinin (CCK), bombesin, calcitonin and naloxone. CCK significantly ...
Gosnell B A - - 1984
Cholecystokinin octapeptide (CCK-8) reduced the amount consumed or the number of licks of several concentrations of sucrose in short-term tests with rats that were hungry, satiated, or fed ad lib. The suppressive effect of CCK-8 was generally smaller in the hungry than in the satiated or ad-lib condition. In the ...
Marks-Kaufman R - - 1984
The effects of chronic naltrexone infusions on food intake and energy balance were examined in male rats. Animals were fed either Purina Chow, or chow plus a 32% sucrose solution. After one week of being maintained on these diets, animals were implanted (intrascapularly) with osmotic minipumps infusing either 200 micrograms/kg/hr ...
West D B - - 1984
Food and water intake of free-feeding rats with indwelling intraperitoneal catheters connected to infusion pumps was continuously monitored and recorded by a microcomputer-based data acquisition system. Initially, at the start of every spontaneous meal for 4 days, each rat was infused with 0.27 ml of physiological saline. Saline infusion did ...
Shillabeer G - - 1984
Cholecystokinin, secreted in response to ingested food entering the duodenum, may play a role in limiting food intake. Inhibition of cholecystokinin should therefore induce an increase in food intake. Proglumide, a specific antagonist of cholecystokinin was used to block the satiety effect of a food preload in rats. A significant ...
van der Kooy D - - 1984
Administration of cholecystokinin (CCK) reduces food intake in rats. This effect of CCK was attenuated in rats with thermal lesions of the area postrema. This result was specific to CCK, as area postrema lesions had no effect on the reduction in food intake produced by amphetamine. The effect of the ...
Bartness T J - - 1984
Previous findings in this laboratory suggest that the cholecystokinin-induced decrease in food intake may be the result of a modulation of the orosensory factors controlling feeding. More recently we have presented evidence indicating that in sated animals the magnitude of cholecystokinin-induced inhibition of intake is proportional to the concentration of ...
Read N W - - 1984
The small bowel transit time of 100 ml of lactulose solution infused at the ligament of Treitz was measured by breath hydrogen excretion in paired studies carried out in 43 healthy volunteers during infusion (1.2 ml/min) of equal volumes (100 ml) of isotonic solutions of either fat emulsion (Intralipid, Prosparol, ...
Willis G L - - 1984
Cholecystokinin (CCK), bombesin and gastrin were stereotaxically injected into catecholamine (CA) innervated areas of the lateral hypothalamus (LH), the nucleus caudatus putamen (NP) and the olfactory tubercle (OT) in male Sprague Dawley rats. Bilateral injections of 100 ng of CCK in 2 microliters of vehicle into the LH produced a ...
Smith G P - - 1984
A review of the satiating effect of cholecystokinin in humans reveals that the synthetic C-terminal octapeptide of cholecystokinin (CCK-8) inhibits liquid and solid food intake in non-obese men and women, and in obese men. Side effects, such as nausea, slight stomach sickness or abdominal cramps are infrequent and transient, and ...
Vanderweele D A - - 1984
The injection of insulin has been used to produce increased food intake and, when given over a period of time, to produce obesity. The hormone, however, is released in 3 distinct phases when subjects encounter and ingest food and one would expect that insulin release would be a correlate, if ...
McLaughlin C L - - 1983
Decreased body weight and increased pancreas weight which occur in rats fed raw soybeans are thought to be due to the presence of trypsin inhibitors in the soybeans (SBTI). Since trypsin is postulated to be a negative feedback signal for cholecystokinin (CCK) secretion, SBTI may have these effects by increasing ...
Lind R W - - 1983
Knife-cut lesions were used to assess the participation of the subfornical organ (SFO) in the central pressor action of intravenously administered angiotensin. Knife-cuts of the ventral stalk of the SFO significantly attenuated pressor responses during infusion of 3 doses of angiotensin, although responses to bolus injections were unaffected. These results ...
Savory C J - - 1983
This paper presents new information about inhibitory effects of intravenous injections of cholecystokinin-octapeptide (CCK-8) on feeding activity in birds, with particular reference to variation in motivational state. With increasing food deprivation (0, 1, 2 or 3 h) before injection, doses of 2 and 8 micrograms/kg CCK-8 became progressively less effective ...
Woods S C - - 1983
Baboons received a 5-minute intravenous infusion of either saline or bombesin (BBS; 1-4 micrograms/kg) following 3 1/2 or 16 1/2 hours of food deprivation and were then allowed to eat for 30 minutes. Plasma insulin was significantly elevated following five minutes of BBS infusion, but there was no change of ...
Crawley J N - - 1983
Cholecystokinin induces a reduction in exploratory behaviors which could reflect an underlying behavioral state of either satiety or malaise. To investigate these alternative hypotheses, the effects of CCK were compared to the effects of (a) consumption of an extra quantity of palatable food, of (b) bombesin at doses known to ...
Larson T - - 1983
This study was designed to determine whether a bombesinlike peptide mediated the gastrin response to food. Tachyphylaxis of gastrin release was induced in six dogs by prolonged infusion of bombesin (500 ng X kg-1 X h-1) before ingestion of a meal. An impaired postprandial gastrin response during bombesin tachyphylaxis would ...
Collins S - - 1983
Intraperitoneal (IP) administration of the glutaramic acid derivative proglumide inhibited satiety induced by all IP doses of cholecystokinin octapeptide (CCK-OP) in 3-hour food-deprived intact rats. Proglumide did not influence satiety when administered alone and did not inhibit satiety induced by IP glucagon. While proglumide did not inhibit satiety induced by ...
Swerdlow N R - - 1983
The net reinforcing/aversive properties of cholecystokinin (CCK) were measured using a conditioned place-preference paradigm. Both sated and food-deprived rats showed a dose dependent aversion to an environment previously paired with CCK that was correlated with the effects of CCK on feeding. In contrast, all rats showed a conditioned preference for ...
Linnestad P - - 1983
The pancreatic polypeptide (PP) release after a standard meal and the PP release and the pancreatic secretion of bicarbonate and amylase after stimulation by secretin GIH, 1 CU kg-1 intravenously, and by cholecystokinin (CCK), 1 Ivy dog unit kg-1 intravenously, have been investigated in 10 patients with chronic pancreatitis. Significant ...
Duranton A - - 1983
Intraduodenal infusion of DL-lactic acid was performed in sheep fitted with a permanent cannula into the lateral cerebral ventricle and nichrome electrodes on the reticulum in order to record its electrical activity during periods of controlled food intake in a series of experiments subsequently repeated in animals fasted for 12 ...
Myers R D - - 1983
In the fasted cat, calmodulin (CaM) infused into the cerebral ventricle produces an increase in the normal intake of food in a dose-dependent manner. The enhancement of feeding by CaM seems to be functionally specific since the response was: (1) abolished by the simultaneous intraventricular infusion of calcineurin, a specific ...
Crawley J N - - 1983
Cholecystokinin (CCK) acts acutely to inhibit food consumption in fasted rats, mice, sheep, pigs, monkeys and humans. CCK has been proposed as a satiety signal, inducing the behavioural sequence of satiety, or as an aversive internal stimulus, which inhibits food intake by inducing malaise. Reductions in food intake and related ...
Bernstein I L - - 1983
A modified learned food aversion paradigm simulated the prolonged food and illness exposure likely to characterize nutrient deficiencies or tumor growth. In this paradigm, a continuously available food was associated with a slow, continuous infusion of LiCl provided by osmotic minipump. Significant aversions were acquired when the available diet was ...
Hsiao S - - 1983
A detailed analysis of the licking response of rats to milk was made. The effects of cholecystokinin (CCK) and bombesin (BBS) on the consummatory response were compared. The normal licking response pattern was found not to change as the meal progressed; no predictor was found to indicate when the meal ...
Larue-Achagiotis C - - 1983
Normal rats with chronic cardiac catheters were infused with regular insulin at various doses (0.1 to 0.6 IU/hr). The insulin infusion was limited to the 12 light hours and repeated for 4 consecutive days. Daytime insulin infusion increased the 12 hr cumulative food intake in a dose-dependent fashion. This increase ...
Baldwin B A - - 1983
The effect of intravenous injections of 0 (Saline vehicle), 10, 20 or 40 units of CCK was studied in pigs performing operant responses for food, water, sucrose solution or radiant heat. In hungry pigs working for food, thirsty pigs responding for water, and non-deprived pigs working for sucrose, 20 and ...
Buéno L - - 1983
Continuous intracerebroventricular (ICV) infusion of CCK-octapeptide (CCK8) was performed in ewes fitted with a permanent cannula into the lateral cerebral ventricle and Nichrome electrodes on the reticulum in order to record its electrical activity. In the first series of experiments, subsequently repeated in 12 h fasted animals, CCK8 was infused ...
Chen F M - - 1983
Chronic infusion of angiotensin II (ANG II) into the olfactory bulb (OB) elicited a moderate dipsogenesis which occurred only during the dark phase, essentially doubling the water-to-food intake ratio. Removal of the food from the ANG II-OB group reduced water consumption to the level of the saline-infused/food-deprived controls. These experiments ...
Faris P L - - 1983
The endogenous neuropeptide cholecystokinin, when administered systemically or perispinally, potently antagonizes opiate analgesia produced by foot shock and morphine. Nonopiate foot-shock analgesia is not reduced by this neuropeptide. The spinal cord appears to be a critical site of cholecystokinin action. These experiments suggest a physiological role for cholecystokinin as a ...
Hsiao S - - 1983
Rats were food-rationed (15 g/day) and trained to bar-press for food. In Experiment 1, the animals were injected with cholecystokinin octapeptide (CCK, 2 micrograms/day), bombesin (BBS, 12 micrograms/kg), normal saline, or prefed with 20 Noyes 45 mg pellets. The animals were then tested for one hour for bar-pressing responses with ...
Inoue K - - 1982
Studies were conducted to determine the effect of resection of the colon on the release of cholecystokinin (CCK) and gastrin. A standard food stimulation test was performed in five dogs. Peripheral blood samples were collected for future measurement of CCK and gastrin by specific radioimmunoassay. Each dog underwent subtotal colectomy ...
McLaughlin C L - - 1982
Many peptides are contained in specific cells distributed throughout the gastrointestinal tract. Some are known to be released by the presence of specific components of food and to affect specific gastrointestinal functions related to digestion and absorption of nutrients. For many of the more recently identified peptides, however, stimuli for ...
Geiselman P J - - 1982
An investigation was made of the role of glucose in the regulation of hunger and satiety in the rabbit. Glucose, when infused intraduodenally at a low rate (1 milliliter per minute), produced a decrease in food intake. However, when glucose was infused into the duodenum at a high rate (3 ...
Pi-Sunyer X - - 1982
Six of eight obese men ate significantly less food during an intravenous infusion of the C-terminal octapeptide of cholecystokinin (CCK-8, 4 ng . kg-1 . min-1) than during a saline infusion in a double blind experimental paradigm. Subjects stopped eating sooner during CCK-8. CCK-8 did not change the rate of ...
Wendt D J - - 1982
Chronic intracarotid cannulation of the common carotid artery was performed in the pigeon. The catheter system of polyethylene tubing consisted of an indwelling component and an injection component. The indwelling component was exteriorized at the occiput so the bird could not reach the catheter with its beak. Following surgery, the ...
Denbow D M - - 1982
The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel. Four-week old chicks were maintained in a thermoneutral environment of 23-24 degrees C. After food was removed for a 24 hr interval, ...
Stacher G - - 1982
Cholecystokinin decreases food intake in animals and in man. This study investigated whether the structurally related ceruletide reduces food intake in healthy non-obese man. Twelve females and 12 males participated, after an over-night fast, in each of two experiments. During the basal 40 min, saline was infused IV. Thereafter, the ...
Levine A S - - 1982
Somatostatin (SS) is considered to be an important regulator of nutrient homeostasis. As such, we felt it would be of use to study in detail its effects on feeding. Intraperitoneal administration of SS (10 microgram/kg) reduces spontaneous nocturnal feeding (3.6 +/- 0.6 g/2 hr vs 1.6 +/- 0.5 g/2 hr, ...
Maggio C A - - 1982
Food-deprived Sprague-Dawley rats were given equicaloric intragastric infusions of mixed meals consisting largely of short- (SCT), medium- (MCT), or long-chain triglyceride (LCT). When animals were allowed to feed 20 min after infusion, there was an immediate reduction of food intake that was sustained over the 2 hr feeding period. During ...
Gibbs J - - 1982
We compared the satiety effects and mechanisms of action of food stimuli delivered to anatomically restricted areas of the gut with the satiety effects and mechanisms of action of the gut peptides cholecystokinin (CCK) and bombesin (BBS). When food is limited to contact with the pregastric and gastric gut surfaces ...
Crawley J N - - 1982
Cholecystokinin (CCK) reduces total food consumption in mice, rats, pigs, sheep, monkeys and humans. Behaviors associated with an underlying state of satiety are reported after CCK administration. Reductions in exploration and social interactions by CCK are not due to true sedation or sleep, as measured by cortical EEG recordings. The ...
Waldbillig R J - - 1982
The intestinal hormone cholecystokinin (CCK) has been shown to play a role in the termination of food intake, however its behavioral mechanism of action remains to be determined. Recent work from this laboratory suggested that the suppression of intake with CCK is dependent upon the specific orosensory characteristics of the ...
Roelfsema F - - 1982
In freely moving rats the diurnal in electrolyte excretion was studied. Food was available during either the dark or the light period. The lights were on from 0800-2000; the dark phase extended from 2000-0800 hrs. The electrolyte excretory rhythms were studied during a control period, in which the minerals were ...
Stacher G - - 1982
Cholecystokinin octapeptide (CCK-OP) was reported to decrease the intake of liquid food in lean and in obese man. This study investigated the effect of CCK-OP on the consumption of real life food, i.e., of standardized sandwiches. Sixteen young non-obese females and males participated, after an overnight fast, each in two ...
Gallavan R H RH - - 1982
The effect of prostaglandin synthesis inhibition on the postprandial intestinal hyperemia was examined in the jejunum of anesthetized dogs. Both intravenous and intra-arterial infusion of the cyclooxygenase inhibitors indomethacin and mefenamic acid reduced resting jejunal blood flow and markedly enhanced the food-induced jejunal hyperemia. The jejunal vascular response to food ...
Houpt K A - - 1982
The evidence for the participation of signals from the gastrointestinal tract in hunger and satiety is reviewed. Various methods of subjecting only certain portions of the gastrointestinal tract to food are described including sham feeding, crossing of the intestines of two animals, and intragastric, intraduodenal and intravenous feeding. These methods ...
Chen F M - - 1982
The effects of continuous infusion of angiotensin II (ANG II, 1 microgram hr-1) into the olfactory bulb (O.B.) were studied on rats with chronically indwelling intracerebral cannulae. Chronic infusion (ALZA minipump system) of ANG II into the O.B. elicited a moderate dipsogenesis as compared to saline infused animals. The increased ...
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