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Kudo-Saito Chie C Division of Cellular Signalling; Institute for Advanced Medical Research; Keio University School of Medicine; Tokyo, - - 2013
In spite of significant advances in our understanding of the metastatic process, the relationship between the dissemination of primary neoplasms to the bones and antitumor immunity remains poorly understood. We have recently identified follistatin-like 1 (FSTL1), a soluble protein secreted by snail family zinc finger 1 (SNAI1)-expressing cancer cells, as ...
Karumbaiah Lohitash - - 2011
Chondroitin sulfate-4,6 (CS-E) glycosaminoglycan (GAG) upregulation in astroglial scars is a major contributor to chondroitin sulfate proteoglycan (CSPG)-mediated inhibition [Gilbert et al. (2005) Mol Cell Neurosci 29:545–558]. However, the role of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S6ST) catalyzed sulfation of CS-E, and its contribution to CSPG-mediated inhibition of CNS regeneration remains to ...
Cao Yuanning - - 2011
Neural tube defects in diabetic embryopathy are associated with increased protein kinase C (PKC)β2 activity and programmed cell death (apoptosis). The apoptosis is triggered by caspase 8, which activates members of the Bcl-2 and caspase families, such as Bid and caspase 3. Whether PKCβ2 regulates caspase 8-induced apoptosis remains to ...
Nakayama Emi - - 2011
Our previous study demonstrated that neutrophils transiently infiltrated into a site where apoptosis had been induced. However, the role of infiltrating neutrophils has not been fully elucidated. In this study, we examined their role in regeneration of the thymus after whole-body X-irradiation by focusing on SDF-1 production. After X-irradiation, the ...
Yamada Yoshihiko - - 2010
In the ovary, clear cell carcinoma (CCC) and endometrioid adenocarcinoma occur in the setting of endometriosis. In this review, we discuss the role of innate immune responses, specifically endogenous ligands (also known as "alarmins"), their pattern recognition receptors (PRRs) and their signaling pathways, in the pathogenesis of ovarian cancer, in ...
Spiegel David A - - 2010
Rationally designing new strategies to control the human immune response stands as a key challenge for the scientific community. Chemical biologists have the opportunity to address specific issues in this area that have important implications for both basic science and clinical medicine.
Taylor Andrew W - - 2010
The phrase "immune privilege" was coined by Peter Medawar to describe the absence of an immune response to allografts placed into the anterior chamber of the eye or brain. We now understand that immune privilege is more than a passive microenvironment with a distinctive anatomical structure that holds back immunity. ...
Witkin S S - - 2011
Immune responses to infection are uniquely regulated during gestation to allow for antimicrobial defence and tissue repair, whilst preventing damage to developing fetal organs or the triggering of preterm labour. A review and analysis of studies delineating gestation-specific immune modulation and intra-amniotic regulation of pro-inflammatory immunity. Identification of the alterations ...
Gilhar Amos - - 2010
Only indirect evidence supports the concept that a collapse of immune privilege (IP) in hair follicles leads to the development of alopecia areata (AA). In this issue, Kang et al. provide further evidence to support this theory, demonstrating downregulation of the expression of several genes important for the immunosuppressive environment ...
Cucco Marco - - 2010
As maintenance of the immune system is energetically costly and resource-limited, trade-offs among immune function, body condition, and reproductive allocation are expected. In this study, we experimentally test the possible trade-off between immune response, self maintenance, and reproductive output in breeding grey partridges Perdix perdix. Before laying, half the females ...
Sanders Melissa E - - 2010
To determine whether immunization with pneumolysin (PLY) protects against pneumococcal endophthalmitis. New Zealand white rabbits were immunized with a mutant form of PLY that retains only 1% of its cytolytic activity until serum IgG titers were ≥51,200. For a negative control, rabbits were immunized with phosphate-buffered saline (mock). Each vitreous ...
Hernández-Martínez Patricia - - 2010
The insect immune system is comprised of both humoral and cellular components that are mobilized in response to parasitic or pathogenic infections. Activation of the immune response implies a considerable expenditure of energy and that is why insects rely on inducible pathways that are activated after coming into contact with ...
Bowie Andrew G - - 2010
In this issue of Immunity, Pérez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein and show that human immunity to the virus HSV-1 is critically dependent on TRAF3.
Diamond Sarah E - - 2011
Immune defences are an important component of fitness. Yet susceptibility to pathogens is common, suggesting the presence of ecological and evolutionary limitations on immune defences. Here, we use structural equation modelling to quantify the direct effects of resource quality and selection history, and their indirect effects mediated via body condition ...
Babin Aurélie - - 2010
Costs of immunity include self-harming autoreactivity through the production of cytotoxic chemicals. While carotenoids stimulate immunity and reduce oxidative stress during immune activity in vertebrates, their involvement in invertebrate immunity is unclear. Recently, a positive correlation between immune defenses and concentration of carotenoids in the hemolymph was demonstrated in the ...
Weber Stephanie C - - 2010
In this issue of Molecular Cell, Han and Mizuuchi present evidence for a possible Turing-like reaction-diffusion mechanism underlying target immunity by the bacteriophage Mu.
Igarashi Kumiko - - 2010
A time-lag study design was used to examine the effects of an immunization programme implemented through an integrated community-based child health approach called the Growth Monitoring Programme Plus (GMP+) in peri-urban areas of Lusaka, Zambia. The immunization coverage and sociodemographic data of eligible children and households were obtained from three ...
Nicolas Emilien - - 2010
Specificity of the Tn4430 target immunity signal was examined by fusing the transposase TnpA to the LacI repressor of Escherichia coli. The resulting chimeric proteins failed to impose immunity to DNA targets carrying copies of the lacO operator, though they were proficient in lacO binding in vivo and remained responsive ...
Papanicolopulu Irini - - 2011
The use of sonar by military vessels during military exercises may produce acoustic pollution of the marine environment. States have an obligation under international law to reduce and control this form of pollution. Regulation of the use of sonar is rendered more complex by the specific regime applicable to warships, ...
Cotter S C - - 2010
Social immune systems comprise immune defences mounted by individuals for the benefit of others (sensuCotter & Kilner 2010a). Just as with other forms of immunity, mounting a social immune response is expected to be costly but so far these fitness costs are unknown. We measured the costs of social immunity ...
Prakash A - - 2010
Immunology plays a crucial role in establishing successful pregnancy. This is primarily due the recognition of fetal antigen and alteration of the immune response mounted by the mother. It is therefore easy to understand the importance of testing for immune causes of reproductive failure and offer immune therapy to those ...
Israeli Moshe - - 2010
BACKGROUND: Common immunosuppression strategies after heart transplantation (HTx) are based on accepted target drug levels, disregarding that drug levels do not correlate with the individual patient's pharmacokinetics or with the actual immunosuppressive drug effect on the patient. The Immuknow assay is used for immune monitoring and management of organ transplant ...
Duclos Philippe - - 2010
The majority of industrialized and some developing countries have formally established national technical advisory bodies to guide immunization policies; other countries are working towards or contemplating the establishment of such bodies. These advisory bodies are often referred to as National Immunization Technical Advisory Groups (NITAGs). A NITAG is a technical ...
Bryson Maggie - - 2010
This systematic review aimed to collect and synthesize information available on immunization policy making processes in countries across the globe. Twenty-nine published articles and five websites in either English or French provided varied information on the immunization policy making processes in 33 countries. The information retrieved varied from players involved ...
Zheng Jingshan - - 2010
The Experts Advisory Committee on Immunization Program (EACIP) of China was founded in 1982, and currently consists of 33 experts in immunization and related fields, selected by the Ministry of Health, to provide advice and guidance on the control of vaccine-preventable diseases. The main tasks of the EACIP are to ...
Fogg Paul C M - - 2010
Bacteriophage lambda has an archetypal immunity system, which prevents the superinfection of its Escherichia coli lysogens. It is now known that superinfection can occur with toxigenic lambda-like phages at a high frequency, and here we demonstrate that the superinfection of a lambda lysogen can lead to the acquisition of additional ...
M?nz Christian - - 2010
Macroautophagy was thought to be an unspecific bulk degradation process. However, Ponpuak et al. (2010) show in this issue of Immunity that cytosolic proteins are selectively recruited to autophagosomes to become metabolized to bactericidal peptides.
Baker Dian L - - 2010
We explored factors associated with perception of barriers to immunization among parents of Hmong origin in California, whose children experience persistent immunization inequities even with health insurance. A partnership of academic researchers and members of the Hmong community conducted a community-based participatory research project. We collected data in naturalistic settings ...
Pérez-Martínez Manuel - - 2010
The adaptive immune response depends on the interaction of T cells and antigen-presenting cells at the immune synapse. Formation of the immune synapse and the subsequent T-cell activation are highly dependent on the actin cytoskeleton. In this work, we describe that T cells express drebrin, a neuronal actin-binding protein. Drebrin ...
Tonteri A - - 2010
Using Atlantic salmon (Salmo salar) as a model system, we investigated whether 18 microsatellites tightly linked to immune-relevant genes have experienced different selection pressures than 76 loci with no obvious association with immune function. Immune-relevant loci were identified as outliers by two outlier tests significantly more often than nonimmune linked ...
Bryson Maggie - - 2010
This paper reports the results of a global survey on the topic of national immunization policy development. Countries reported on actors involved, sources of evidence consulted, challenges faced and desired changes in their immunization policy development processes. Most countries had established or would like to establish a national Immunization Technical ...
Gershman S N - - 2010
Inbreeding is assumed to have negative effects on fitness, including the reduced ability to withstand immune challenges. We examined the immunological consequences of inbreeding in decorated crickets, Gryllodes sigillatus, by comparing lytic activity, phenoloxidase (PO) activity, and encapsulation ability of crickets from eight inbred lines with that of crickets from ...
Palmer Caroline V - - 2010
Immunity is a key life history trait that may explain hierarchies in the susceptibility of corals to disease and thermal bleaching, two of the greatest current threats to coral health and the persistence of tropical reefs. Despite their ongoing and rapid global decline, there have been few investigations into the ...
Heininger Ulrich - - 2010
Pertussis (or whooping cough) is a frequent and important infectious disease of the respiratory tract, mainly caused by the Gram-negative rod bacterium Bordetella pertussis. Although it is frequently believed that pertussis is exclusively a 'childhood disease', in reality it occurs at any age but is most serious in young infants. ...
Zhou Ru - - 2010
The eye attempts to limit local immune and inflammatory responses to preserve vision. This phenomenon, known as ocular immune privilege, is mediated by a combination of local and systemic mechanisms. While immune privilege is believed to protect the eye from day-to-day inflammatory insults, it is not absolute and its mechanisms ...
Grunau Brian E - - 2010
Despite successful large-scale immunization programs in North America, there remains a significant population without active immunity to tetanus toxins because immunizations have been refused or delayed, and because of waning immunity. We report the case of a 7-year-old boy who presented to the emergency department with a chin laceration and ...
Picard Clément - - 2010
Diffuse alveolar haemorrhage (DAH) is a life-threatening condition due to immune and non-immune causes. Early identification of an underlying immune disorder is essential in order to initiate appropriate treatment. The purpose of this study was to identify early predictive factors of an immune cause of DAH. We conducted a retrospective ...
Niederkorn Jerry Y - - 2010
Immune privilege is the condition in which selected immune responses are suppressed or excluded in certain organs, such as the eye. Immune privilege in the eye was described over 130 years ago, but its significance was not appreciated until the early 1950s. Investigations beginning in the 1970s ushered in a ...
Robison Steve G - - 2010
A challenge facing immunization registries is developing measures of childhood immunization coverage that contain more information for setting policy than present vaccine series up-to-date (UTD) rates. This study combined milestone analysis with provider encounter data to determine when children either do not receive indicated immunizations during medical encounters or fail ...
Ge Jun - - 2010
We describe a new immunity mechanism that protects actively replicating/transposing Mu from self-integration. We show that this mechanism is distinct from the established cis-immunity mechanism, which operates by removal of MuB protein from DNA adjacent to Mu ends. MuB normally promotes integration into DNA to which it is bound, hence ...
Luthy Karlen E - - 2010
OBJECTIVES: To determine why parents in a Utah community hesitated in immunizing their children. DESIGN AND SAMPLE: Cross-sectional descriptive study. Data were collected from a convenience sample of 86 parents of under-immunized children in the county health department and local pediatric and family practice offices. MEASURES: Participants were asked to ...
Mathews John D - - 2010
The ecology of influenza may be more complex than is usually assumed. For example, despite multiple waves in the influenza pandemic of 1918-19, many people in urban locations were apparently unaffected. Were they unexposed, or protected by pre-existing cross-immunity in the first wave, by acquired immunity in later waves, or ...
Guinan Eva - - 2010
An important barrier to the success of transplanting haploidentical hematopoietic stem cells is delayed reconstitution of immune cells that provide protection from opportunistic infections and recurrent malignancy. In recent years a large research effort has been directed toward improving immune reconstitution through methods that potentially spare these cells while simultaneously ...
Thomas M - - 2010
INTRODUCTION: Auto-immune pemphigus is an organ-specific immune disorder due to pathogenic auto-antibodies. Both genetic and environmental factors have been associated with the occurrence of auto-immune pemphigus. Little is known about the epidemiology of auto-immune pemphigus in western Europe. OBJECTIVE: To evaluate the incidence of auto-immune pemphigus in south-western France (namely ...
Ma Zhaipu - - 2010
Through analyzing the immunity indicators in recent crustacean research, two defects are pointed in comprehensive immunity evaluation, 1) the integrant indicators cannot comprehensively reflect the change of immunity, and 2) the conclusions that obtained from different indicators of immunity level cannot be compared objectively and scientifically. Basing on that, the ...
Bascu??n-Garc?a Ana Priscila - - 2010
We investigated whether an immune response is associated with growth, female reproduction and survival costs in the house cricket. Using different intensities of challenge immune (implantation of one piece of nylon (1N) and two nylons (2N), with their respective sham-challenge and control groups) with body size and exoskeleton thickness as ...
Beltman Joost B - - 2009
The visualization of the dynamic behaviour of and interactions between immune cells using time-lapse video microscopy has an important role in modern immunology. To draw robust conclusions, quantification of such cell migration is required. However, imaging experiments are associated with various artefacts that can affect the estimated positions of the ...
Wearing Helen J - - 2009
Case notifications of pertussis have shown an increase in a number of countries with high rates of routine pediatric immunization. This has led to significant public health concerns over a possible pertussis re-emergence. A leading proposed explanation for the observed increase in incidence is the loss of immunity to pertussis, ...
Schauer Stephanie L - - 2009
Measuring progress toward national immunization objectives at the local level, although difficult, is becoming more feasible owing to statewide immunization information systems. This article describes how a state immunization program expanded the scope of immunization service contracts with local health departments (LHDs) to address the immunization rates among children living ...
Song Chunyuan - - 2009
A highly sensitive immunoassay based on surface enhanced Raman scattering (SERS) has been developed with a novel immune marker named as Raman reporter-labeled immuno-Au aggregates on a SERS-active immune substrate. The features of those immune aggregates were characterized by UV-vis extinction spectra, TEM images, SEM pictures and SERS spectra. It ...
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