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Griffin Matthew D - - 2012
Mononuclear phagocytes (macrophages, dendritic cells, and monocytes) play a complex role in kidney disease. Techniques for selectively depleting them in rodents have made important contributions but have also generated some contradictory results. Ferenbach et al. report that two widely used mononuclear phagocyte depletion techniques differentially affect early severity of renal ...
Hodge Lisa M - - 2012
Pneumonia is a common cause of morbidity and mortality worldwide. While antibiotics are generally effective for the treatment of infection, the emergence of resistant strains of bacteria threatens their success. The osteopathic medical profession has designed a set of manipulative techniques called lymphatic pump techniques (LPT), to enhance the flow ...
James R R - - 2011
The current state of knowledge regarding the effect of pesticides on insect immunity is reviewed here. A basic understanding of these interactions is needed for several reasons, including to improve methods for controlling pest insects in agricultural settings, for controlling insect vectors of human diseases, and for reducing mortality in ...
Zhang Lan - - 2011
BACKGROUND: In recent years, concerns over the potential impact of synthetic pesticides on the environment have made the discovery and development of environmentally friendly pesticides a more pressing issue. Camptothecin (CPT) and its derivatives have attracted much attention owing to their unique mechanisms of action against insects. In this paper, ...
Pérez-Maldonado Iván N - - 2011
Context: In previous studies, we showed that DDT and its metabolites are able to induce apoptosis of peripheral blood mononuclear cells (PBMC) "in vitro" and "in vivo", by a mechanism involving oxidative stress. Objective: The objective of this study was to evaluate the mechanism by which DDT induces apoptosis in ...
Giribaldi Laura - - 2011
Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the biosphere. The aim of the present study was to investigate the effect of HCB on the homeostasis of liver cell growth, analyzing parameters of cell proliferation and apoptosis, in HCB (0.1, 1, 10 and 100mg/kg body weight)-treated rats, during 4 ...
Svajger Urban - - 2011
DC-SIGN is a C-type lectin selectively expressed by certain types of DCs, including monocyte-derived DCs. Many reports have described the impact of DC-SIGN engagement with concomitant TLR signaling in tailoring of the DC maturation process, but so far, none has addressed the importance of DC-SIGN engagement during their differentiation from ...
Liao Che-Feng - - 2011
Abstract DC-SIGN, a C-type lection expressed on dendritic cells, enhances HIV-1 infection in cis and in trans. HIV-1 circulating recombinant form (CRF) 07_BC viruses have been the predominant strain found among injection drug users in southern China and Taiwan. The goal of this study was to map the DC-SIGN-interactive domain ...
Hayley Shawn - - 2011
The geographic distribution of environmental toxins is generally not uniform, with certain northern regions showing a particularly high concentration of pesticides, heavy metals and persistent organic pollutants. For instance, Northern Canadians are exposed to high levels of persistent organic pollutants like polychlorinated biphenyls (PCB), organochlorine pesticides (OCs) and methylmercury (MeHg), ...
Izquierdo-Useros Nuria - - 2011
Retroviruses appropriate pre-existing cellular machineries to propagate. In the last decade, impressive similarities have been observed in the generation and dissemination in the host cells of retroviruses and small cellular vesicles known as exosomes. These cellular vesicles are thought to facilitate intercellular communication processes and mediate immune functions. However, their ...
Brink Peter R - - 2010
Current in vivo approaches for the delivery of siRNAs have been hindered by inefficient targeting to cells and by the triggering of immune responses. The cellular delivery of siRNA by immunoprivileged cells avoids the immune response, because the siRNA is delivered from one cell interior to another via gap junctions, ...
Rommel Christian - - 2010
The multiple roles of PI3Kδ (p110δ) and PI3Kγ (p110γ) in various immune cells have encouraged the development of small-molecule inhibitors of both PI3K isoforms, alone or in combination, for the treatment of immune-mediated inflamatory diseases. Recent findings suggest a previously unrecognized interdependent cooperativity between p110δ and p110γ, if not all ...
Schmidt Otto - - 2010
The recognition and inactivation of toxins and pathogens are mediated by a combination of cell-free and cellular mechanisms. A number of soluble and membrane-bound pattern recognition molecules interact with elicitors to become involved in both cell-free inactivation as well as cellular uptake reactions. Here we describe the possible recognition and ...
Deane Sean - - 2010
First described in 1735 (Watson-Williams et al., 1958), immune-mediated platelet destruction is a phenomenon of protean associations that has historically varied in its definition. Recently, consensus guidelines were proposed for a standardized system of nomenclature that preserves the acronym "ITP" but encompasses a number of causes of immune-mediated thrombocytopenias, including ...
Matthews Andrew - - 2009
Equine immune mediated keratopathies are common in both Europe and the USA. This review article will compare the clinical differences in horses with this disease and also review the current theories on pathogenesis and treatment of equine IMMK.
Salio Mariolina - - 2009
Immune activation is often associated with inflammation, but inflammation's role in the expansion of antigen-specific immune responses remains unclear. This primer focuses on recent findings that show how specific natural killer T cells are activated by inflammatory messengers, thus illuminating the cellular and molecular links between immunity and inflammation.
Jalil Aishah A - - 2010
Electrochemical dechlorination of chlorobenzenes in the presence of various arene mediators such as naphthalene, biphenyl, phenanthrene, anthracene, and pyrene, was studied. The amount of mediator required was able to be reduced to 0.01 equiv. for all mediators except for anthracene, with the complete dechlorination of mono-, 1,3-di- and 1,2,4-trichlorobenzene still ...
Kalnina Inta - - 2010
The fluorescent probe ABM (3-aminobenzanthrone derivative) one of the fluorescent probes synthesized in Riga Technical University proved to be an excellent, independent model for studying cell membranes. In our work we have investigated the possibility of using the fluorescent probe ABM for detection of immune state in patients with different ...
Chouvenc Thomas - - 2009
Reticulitermes flavipes workers were topically inoculated with approximately 10,000 conidia of the entomopathogenic fungus Metarhizium anisopliae. After being kept in groups of 20 individuals for 1-9 d, histopathological examination showed that termites had an individual immune reaction. The nodule formation at the point of entrance of the fungal hyphae was ...
Monteleone Giovanni - - 2009
Interleukin-21 (IL-21) is produced mostly by activated CD4+ T cells and controls the differentiation and functional activity of effector T helper cells, counteracts the suppressive effects of regulatory T cells, and stimulates non-immune cells to make inflammatory mediators. IL-21-driven tissue damage has been demonstrated in a number of organs, such ...
Kim Geun Seob - - 2009
Octopamine and 5-hydroxytryptamine (5-HT) have been known to mediate cellular immune responses, such as hemocytic phagocytosis and nodule formation, during bacterial invasion in some insects. In addition, eicosanoids also mediate these cellular immune reactions in various insects, resulting in clearing the bacteria circulating in the hemolymph. This study investigated a ...
VanderWeele Tyler J - - 2009
The concepts of mediation and mechanism are contrasted and logical implications holding between theses two concepts are described. The concept of mediation can be formalized using counterfactual definitions of indirect effects; the concept of mechanism can be formalized within the sufficient cause framework. It is shown that both concepts can ...
Tsirigotis Panagiotis D - - 2009
Immune-mediated cytopenias after allogeneic stem cell transplantation can be categorized as either alloimmune when host or donor immunity reacts against donor or host elements, respectively, or autoimmune when donor immunity reacts against donor hematopoietic tissue, owing to poorly understood mechanisms that result in severe impairment of central and peripheral tolerance. ...
Al-Ghazlat Suliman - - 2009
The author describes the range of current treatment options for dogs with this potentially deadly condition.
Pingle Shubhangi K - - 2008
Neopterin is regarded as an early biomarker of the cellular immune response. This low molecular mass compound belongs to the class of pteridine and is a metabolite of guanosine triphosphate, which is produced by the activated macrophages and dendritic cells after stimulation with gamma-interferon. An international group acknowledges the fact ...
Nitschke Cindy - - 2008
Analyzing the dynamics of cellular immune responses, although performed for decades in immunologic research, has seen an enormous increase in the number of studies using this approach since the development of intravital 2-photon microscopy. Meanwhile, new insights into the dynamics of cellular immunity are being published on a daily basis. ...
Vivoda Jonathon M - - 2008
OBJECTIVE: Use of a cellular phone has been shown to negatively affect one's attention to the driving task, leading to an increase in crash risk. At any given daylight hour, about 6% of US drivers are actively talking on a hand-held cell phone. However, previous surveys have focused only on ...
Pingle Shubhangi
Neopterin is regarded as an early biomarker of the cellular immune response. This low molecular mass compound belongs to the class of pteridine and is a metabolite of guanosine triphosphate, which is produced by the activated macrophages and dendritic cells after stimulation with γ-interferon. An international group acknowledges the fact ...
Abdulahad, Wayel Habib
Although the pathogenetic mechanisms involved in Wegener’s granulomatosis (WG) are not completely understood, considerable evidence support the concepts that activated T-cells play an important role in disease expression. It is, however, not clear which subsets of T-cells are involved in the aberrant (auto)immune response in WG. Zie: Chapter 8
França Marcondes C MC - - 2007
Inflammatory myopathies (IM) are a heterogeneous group of diseases characterized by immune-mediated damage to skeletal muscle. Sensory abnormalities are rare in patients with IM. We report two patients, one with dermatomyositis and the other with inclusion-body myositis, who presented with unexpected sensory abnormalities due to probable immune-mediated damage to dorsal ...
Harnett Margaret M MM Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, G12 8TA, UK. - - 2007
Flow cytometry allows quantitative analysis of the identity and effector function of individual cells. However, it cannot provide information on cellular responses that occur within physiological tissue microenvironments. Laser scanning cytometry is an emerging technology that allows imaging and quantitative analysis of individual cells in tissues in situ. This article ...
Gautam Amitabh - - 2007
Infection with lymphocytic choriomeningitis virus (LCMV) in rodents, the primary host, is known to cause suppression of cell-mediated immunity. Serial determinations using a functional cell-mediated immune assay in a kidney transplant recipient with donor-transmitted LCMV also suggested profound suppression of cellular immunity. This suppression persisted in spite of reduction of ...
Segerstrom Suzanne C - - 2006
Studies have linked optimism to poorer immunity during difficult stressors. In this study, when 1st-year law students (N = 46) relocated to attend law school, reducing conflict among curricular and extracurricular goals, optimism predicted larger delayed-type hypersensitivity responses, indicating more robust in vivo cellular immunity. However, when students did not ...
Trapani Joseph A - - 2006
Apoptosis and Immunity 2005 was the ninth in a series of conferences centred on cellular immunity and particularly the molecular and cellular biology of cytotoxic lymphocytes, the first of which was held in Marseilles in 1981. More than 80 delegates from 20 countries attended the conference, which was held in ...
Kølsen-Petersen Jens A - - 2004
BACKGROUND: Previous studies found hypertonicity to affect immune responses in intact laboratory animals and in human blood cell cultures. In this study, the authors investigated the cellular immune response to surgery after preoperative infusion of hypertonic saline in humans. METHODS: Sixty-two women scheduled to undergo abdominal hysterectomy were randomly assigned ...
Gonçalves Maria Alice Guimarães - - 2004
Although cellular immunity is essential for the elimination of human papillomavirus (HPV), the mechanisms involved are still poorly understood. We summarize the main mechanisms involved in cellular immune response to infections caused by HPV. Immunotherapies for HPV-related cancers require the disruption of T-cell response control mechanisms, associated with the stimulation ...
Perkins M C - - 2004
Five cases of suspected immune-mediated neutropenia in dogs are described. Clinical signs varied depending on whether the animals had a systemic infection or concurrent immune-mediated disease. Patients were diagnosed by excluding other causes of neutropenia, supportive bone marrow aspirate findings, an initial favourable response to corticosteroid administration in four of ...
Pruss A - - 2003
The differential diagnosis of anemia must consider immune hemolytic anemias as a frequent cause. Whereas detection of anti-red blood cell (RBC) alloantibodies frequently induced by immunogenic stimuli (transfusion, pregnancy) is performed by routine serology, diagnosing autoimmune hemolytic anemias or drug-induced hemolytic anemias remains a challenge, usually requiring close collaboration of ...
Kamei Ken-ichiro - - 2003
An immune cellular biosensing system has been constructed to assess immunomodulating effects of chemicals. Production of nitric oxide in the immune cellular biosensing system was used as readout of an immune cellular response for assessing the immunomodulating effects of chemicals. The macrophage-like cell line RAW264.7, which has signaling pathways of ...
Young, Lauren Jill
This thesis describes a comprehensive study of the cellular responses of a number of endangered marsupial species with a principal focus on the tammar wallaby (Macropus eugenii) as a model macropod species. The development of in vitro experimental assays for the assessment of immune responses in this model species are ...
Greenberg P D - - 1999
The critical role of cellular immunity in resistance to infectious diseases is glaringly revealed by life-threatening infections if T cell function is disrupted by an inherited or acquired immunodeficiency. Although treatment has historically focused on infectious complications, understanding of the cellular and molecular basis of immunodeficiency and technologies useful for ...
Veldman J - - 1998
A review is given on the way our knowledge of pathways of immune responses inside and in the immediate vicinity of the inner ear has gradually developed over the past two decades. Immune reactivity plays a more important role in the etiopathogenesis and natural course of various inner ear disorders ...
Winkelstein A - - 1997
Immunohematology encompasses a broad array of clinical disorders in which immune reactions are involved in the pathogenesis of hematologic diseases. Immune reactions can involve the formed elements of the blood, producing hemolytic anemia, thrombocytopenia, or neutropenia. Autoimmune phenomena and drug-induced reactions are the most common mechanisms. In newborns, maternal antibodies ...
Smiley S T - - 1997
Extravascular procoagulant activity often accompanies cell-mediated immune responses and systemic administration of pharmacologic anticoagulants prevents cell-mediated delayed-type hypersensitivity reactions. These observations suggest a direct association between coagulation and cell-mediated immunity. The cytokine interleukin (IL)-4 potently suppresses cell-mediated immune responses, but its mechanism of action remains to be determined. Herein we ...
Miller E - - 1997
Currently available therapeutic protocols for immune-mediated diseases in dogs and cats can be associated with poor response rates and a high incidence of side effects. The development of multidrug protocols often results in a synergistic effect that more efficiently suppresses the immune response. One drug that may be added to ...
Mege J L - - 1997
Although substantial progress occurred in the knowledge of Coxiella burnetii during the past years, the pathophysiology of Q fever is still obscure. Emerging evidence from clinical investigations suggested that certain disorders of cell-mediated immunity play a pivotal role in Q fever and especially in its chronic form. This review analyses ...
Kuwano K - - 1997
The role of cellular immunity in mycoplasma infection is not completely understood. In this study, we established mycoplasma-specific T-cell clones to evaluate cellular immunity in mycoplasma infection. We developed a T-cell clone (G-10) which was stimulated with Acholeplasma laidlawii. The T-cell clone G-10, CD4+ and T-cell receptor (TCR) alpha beta- ...
Patarca R - - 1995
The realization that dysregulation of the soluble immune mediator network can contribute to the progression of a wide variety of clinical disorders, including neoplasias, has opened up the possibility of designing new forms of therapy and has established the need for accurate methods of detection of immune mediator expression levels ...
Watson I P - - 1993
OBJECTIVE: To explore immune function in patients with chronic post-traumatic stress disorder (PTSD). DESIGN: A case-control study using the standardised Cell-mediated Immunity (CMI) Multitest. PARTICIPANTS: Cases were 25 Vietnam combat veterans undergoing treatment for clinically diagnosed PTSD. Controls had no diagnosed psychiatric disorders: 28 were civilians and 20 were servicemen ...
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