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Li Li-Fu LF Department of Medicine, Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333, - - 2014
Mechanical ventilation used in patients with acute lung injury can damage pulmonary epithelial cells through production of inflammatory cytokines, oxygen radicals, and neutrophil infiltration, termed ventilator-induced lung injury. Neutrophil elastase, nuclear factor-κB (NF-κB), and NF-κB repressing factor (NRF) have previously been shown to participate in the regulation of macrophage inflammatory ...
Proctor William R WR Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, - - 2014
Liver eosinophilia has been associated with incidences of drug-induced liver injury (DILI) for more than 50 years, although its role in this disease has remained largely unknown. In this regard, we recently showed for the first time that eosinophils played a pathogenic role in a mouse model of halothane-induced liver ...
Camara-Lemarroy Carlos Rodrigo CR Carlos Rodrigo Camara-Lemarroy, Departamento de Medicina Interna, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, NL 64460, - - 2014
Common gastrointestinal diseases such as radiation enteritis (RE), acute pancreatitis, inflammatory bowel diseases (IBD) and drug-induced hepatotoxicity share pathophysiological mechanisms at the molecular level, mostly involving the activation of many pathways of the immune response, ultimately leading to tissue injury. Increased oxidative stress, inflammatory cytokine release, inflammatory cell infiltration and ...
Gong Jie J Department of Critical Care Medicine, Institute of Anesthesia and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, - - 2014
Acute lung injury is a severe illness with a high rate of mortality. Maresin1 (MaR1) was recently reported to regulate inflammatory responses. We used a lipopolysaccharide (LPS)-induced acute lung injury model to determine whether MaR1 could mitigate the lung injury. Male BALB/c mice were exposed to intratracheal administration of either ...
Gesuete Raffaella R From the Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland (RG, MPS-P); and Division of Neuroscience, Oregon National Primate Research Center, Beaverton (SGK), - - 2014
Toll-like receptors (TLRs) are master regulators of innate immunity and play an integral role in the activation of inflammatory response during infections. In addition, TLRs influence the body's response to numerous forms of injury. Recent data have shown that TLRs play a modulating role in ischemic brain damage after stroke. ...
Chen Jiao J Center for Research on Environmental Disease, University of Kentucky, Lexington, KY 40536, - - 2014
The presence of endotoxin in blood can lead to acute kidney injury (AKI) and septic shock. Resolvins, the endogenous lipid mediators derived from docosahexaenoic acid, have been reported to exhibit potent anti-inflammatory action. Using a mouse model of lipopolysaccharide (LPS)-induced AKI, we investigated the effects of aspirin-triggered resolvin D1 (AT-RvD1) ...
Inoue Yoshiyuki Y Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi 329-0498, - - 2014
Inflammation plays a key role in the pathophysiology of hepatic ischemia-reperfusion (I/R) injury. However, the mechanism by which hepatic I/R induces inflammatory responses remains unclear. Recent evidence indicates that a sterile inflammatory response triggered by I/R is mediated through a multiple-protein complex called the inflammasome. Therefore, we investigated the role ...
Zou Yinggang Y Department of Human Anatomy, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China ; Department of Obstetrics and Gynecology, Second Hospital, Jilin University, Changchun, Jilin 130041, P.R. - - 2014
Optimization of intratracheal instillation is necessary to establish an ideal animal model of acute lung injury (ALI) in order to further reveal the cellular and molecular pathogenesis of ALI. It is possible that instilling air from a prefilled syringe may promote the delivery of reagents into the alveolar spaces, resulting ...
Wu Xiaodan X Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, - - 2014
Bone marrow-derived mesenchymal stem cells (BMSCs) could modulate inflammation in experimental lung injury. On the other hand, adrenergic receptor agonists could increase DNA synthesis of stem cells. Therefore, we investigated the therapeutic role of adrenaline-stimulated BMSCs on lipopolysaccharide (LPS)-induced lung injury. BMSCs were cultured with adrenergic receptor agonists or antagonists. ...
Aggarwal Neil R NR Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD - - 2014
Overwhelming lung inflammation frequently occurs following exposure to both direct infectious and noninfectious agents and is a leading cause of mortality worldwide. In that context, immunomodulatory strategies may be used to limit severity of impending organ damage. We sought to determine whether priming the lung by activating the immune system, ...
Kawabori Masahito M Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA, 94121, - - 2014
Microglia are considered the brain's resident immune cell involved in immune defense, immunocompetence, and phagocytosis. They maintain tissue homeostasis within the brain and spinal cord under normal condition and serves as its initial host defense system. However, when the central nervous system (CNS) faces injury, microglia respond through signaling molecules ...
Tang Shih-En SE Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, - - 2014
Stanniocalcin-1 (STC1) is an endogenous glycoprotein whose anti-inflammatory effects occur through induction of uncoupling proteins to reduce oxidative stress. In this study, we tested the hypothesis that exogenous recombinant human STC1 (rhSTC1) protects against lipopolysaccharide (LPS)-induced acute lung injury in mice. Anesthetized C57BL/6 mice underwent intratracheal spraying of LPS (20μg/10g ...
Xiao Xiao X 1Medical College of Georgia, Georgia Regents - - 2014
Acute kidney injury (AKI) is associated with mitochondrial fragmentation, which contributes to mitochondrial damage and tubular cell apoptosis. Mitochondrial fragmentation involves the cleavage of both mitochondrial outer and inner membranes. Cleavage of the outer membrane results from Drp-1-mediated fission activation and Bak-promoted fusion arrest, but the molecular mechanism of inner ...
Nakajima Takeshi T University of California, San Diego, Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Diego, California, United States ; - - 2014
Acute lung injury (ALI) is characterized by pulmonary inflammation and edema. Innate immune cells, e.g., neutrophils and macrophages, are major contributors to inflammation in ALI. Less is known regarding the role of T cells. We examined the effects of rapamycin on inflammation in a lipopolysaccharide (LPS)-induced murine model of ALI. ...
Lehmann C C Department of Anaesthesia, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address: - - 2014
Central nervous system (CNS) injury is classified as an independent factor, increasing patients' susceptibility to infections. The concept of infection susceptibility and impaired immune function is referred to as CNS-injury induced immunodeficiency syndrome (CIDS). The endocannabinoid system, an important homeostatic system that can modulate immune function, contributes to the consequences ...
Yan Jun J Department of Musculoskeletal Oncology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai , - - 2014
Despite the progress made in the clinical management of sepsis, sepsis morbidity and mortality rates remain high. The inflammatory pathogenesis and organ injury leading to death from sepsis are not fully understood for vital organs, especially the liver. Only recently has the role of the liver in sepsis begun to ...
Cai Ye Y Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. - - 2014
Dexmedetomidine (DEX), a highly specific α2‑adrenergic agonist, which exhibits anaesthetic‑sparing, analgesia and sympatholytic properties. DEX modulates gene expression, channel activation, transmitter release, inflammatory processes and apoptotic and necrotic cell death. It has also been demonstrated to have protective effects in a variety of animal models of ischemia/reperfusion (I/R) injury, including ...
Casalena Gabriella G 1Icahn School of Medicine at Mount - - 2014
Mitochondrial dysfunction is increasingly recognized as contributing to glomerular diseases, including those secondary to mitochondrial DNA (mtDNA) mutations and deletions. Mitochondria maintain cellular redox and energy homeostasis and are a major source of intracellular reactive oxygen species (ROS) production. Mitochondrial ROS accumulation may contribute to stress-induced mitochondrial dysfunction and apoptosis ...
Moreno-Vinasco Liliana L University of Illinois Chicago, Pulmonary, IPRM, Medicine,, Chicago, Illinois, United States ; - - 2014
We previously identified the intracellular nicotinamide phosphoribosyltransferase (iNAMPT, aka pre-B cell colony enhancing factor, PBEF), as a candidate gene promoting both acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI) with circulating NAMPT potently inducing NFkB signaling in lung endothelium. Intracellular NAMPT also synthesizes nicotinamide adenine dinucleotide (iNAD) in ...
Morishita Koji K From the Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California, San Diego Health Sciences, San Diego, - - 2014
Previous studies have established that posthemorrhagic shock mesenteric lymph (PHSML) contains proinflammatory mediators, while the cellular basis of PHSML is less well characterized in acute models of injury. CD103 dendritic cells (DCs) have been identified in the mesenteric lymph (ML) in models of chronic intestinal inflammation, suggesting an important role ...
Wang Lei L Department of Anesthesia and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, - - 2014
A variety of inflammatory mediators and effector cells participate together in acute lung injury, and lead to secondary injury that is due to an inflammatory cascade and secondary diffuse lung parenchyma injury. Inflammation is associated with an oxidative stress reaction, which is produced in the development of airway inflammation, and ...
Li Xingwang X Department of Anesthesiology, Second Hospital, Wenzhou Medical College, Wenzhou, Zhejiang 325027, - - 2014
Protectin D1 (PD1), derived from docosahexaenoic acid, has been shown to control and resolve inflammation in some experimental models of inflammatory disorders. We investigated the protective roles of protectin D1 in pulmonary inflammation and lung injury induced by lipopolysaccharide (LPS). Mice were randomly assigned to six groups (n = 6 ...
Anderson Stacy L SL Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, - - 2014
To review the immune response to anesthesia including mechanical ventilation, inhaled anesthetic gases, and injectable anesthetics and sedatives. Review. Multiple literature searches were performed using PubMed and Google Scholar from spring 2012 through fall 2013. Relevant anesthetic and immune terms were used to search databases without year published or species ...
Zhong Weiting W Department of Respiration, the First Hospital of Jilin University, 71 Xinmin Road, Changchun, 130021, People's Republic of - - 2014
The object of our study is to investigate the protective effects of Borneol on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. To determine the effects of Borneol on the histopathological changes in mice with ALI, inflammatory cell count in bronchoalveolar lavage fluid (BALF) and lung wet/dry weight ratio were ...
Metushi Imir G - - 2014
Isoniazid (INH) remains a mainstay for the treatment of tuberculosis despite the fact that it can cause liver failure. The mechanism of INH-induced liver injury remains controversial. It had been proposed that the mechanism involves "metabolic idiosyncrasy" based on the observations that liver injury is not usually associated with fever, ...
Faure Emmanuel E Lille School of Medicine - UDSL - Lille North of France University, Pseudomonas aeruginosa host-pathogen translational research group, Lille, France ; - - 2014
Rationale. Pseudomonas aeruginosa, a major problem pathogen responsible for severe infections in critically ill patients, triggers, through a functional type-three secretion system (T3SS), the activation of an intracellular cytosolic sensor of innate immunity, NLRC4. While the NLRC4-inflammasome-dependent response contributes to increased clearance of intracellular pathogens, it seems that NLRC4-inflammasome activation ...
Gong Gu G Department of Anesthesia, General Hospital of Chengdu Military Area Command, Chengdu, 610000, Sichuan, - - 2014
Lipopolysaccharide (LPS) preconditioning is a powerful neuroprotective phenomenon by which an injurious stimulus renders the brain resistant to a subsequent damaging ischemic insult. The LPS response gene (Lrg) is a recently identified gene in human dental pulp cells treated with LPS. However, the role and mechanism of Lrg in brain ...
Wu Bangwei B The Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, - - 2014
Innate immune and inflammatory responses are involved in myocardial ischemia/reperfusion (I/R) injury. IL-37 is a newly identified member of the IL-1 family, and functions as a fundamental inhibitor of innate immunity and inflammation. However, its role in myocardial I/R injury remains unknown. I/R or sham operations were performed on male ...
Hiroshima Yuka Y Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, New South Wales 2052, - - 2014
S100A8 is considered proinflammatory by activating TLR4 and/or the receptor for advanced glycation end products. The aim was to investigate inflammatory effects of S100A8 in murine lung. S100A8 was administered to BALB/c mice by nasal inhalation and genes induced over a time-course assessed. LPS was introduced intranasally either alone or ...
Aggarwal Neil R NR 1Johns Hopkins - - 2014
Acute respiratory distress syndrome (ARDS) is a devastating disease with distinct pathological stages. Fundamental to ARDS is the acute onset of lung inflammation as a part of the body's immune response to a variety of local and systemic stimuli. In patients surviving the inflammatory and subsequent fibroproliferative stages, transition from ...
Siniscalchi Antonio - - 2014
Abstract Stroke represents the most frequent cause of permanent disability in adults worldwide. Cerebral ischemia triggers the pathological pathways of the ischemic cascade and causes irreversible neuronal injury in the ischemic core within minutes of the onset. Elements of the immune system are involved in all stages of ischemic cascade ...
Yang Huaisong H Department of Emergency Medicine, The General Hospital of Shenyang Military District, Shenyang, Liaoning Province, - - 2014
Sepsis is the leading cause of death in the intensive care units worldwide. Proinflammatory cytokines such as TNF-α and IL-6 mediate the pathogenesis of septic shock characterized by hemodynamic instability and end-stage multi-organ functional failure. Brain natriuretic peptide (BNP) has been used as a diagnostic and prognostic biomarker in the ...
Castellaneta Antonino A Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA; Present address: Unit of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Bari, - - 2014
Plasmacytoid dendritic cells (pDC) constitute the body's principal source of type I interferon (IFN) and are comparatively abundant in the liver. Among various cytokines implicated in liver ischemia and reperfusion (I/R) injury, type I IFNs have been described recently as playing an essential role in its pathogenesis. Moreover, type I ...
Willam Carsten C Department of Nephrology and Hypertension, University Erlangen-Nuremberg, Erlangen, - - 2014
An inflammatory stimulus prior to an ischemic insult can be protective in acute kidney injury (AKI) as well as other acute organ injury models, an effect called cross-tolerance. He et al. investigated mechanisms of cross-tolerance whereby pretreatment with lipopolysaccharide (LPS) protects from a subsequent ischemic insult of the kidney. The ...
Chen Sheng S Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, - - 2014
Acute central nervous system (CNS) injuries, including stroke, traumatic brain injury (TBI), and spinal cord injury (SCI), are common causes of human disabilities and deaths, but the pathophysiology of these diseases is not fully elucidated and, thus, effective pharmacotherapies are still lacking. Valproic acid (VPA), an inhibitor of histone deacetylation, ...
Lassmann Hans H Center for Brain Research, Medical University of Vienna, - - 2014
Glia cells are mediators as well as targets of the chronic inflammatory process in the central nervous system of multiple sclerosis (MS) patients. They are involved in the control of autoimmunity, in the propagation and termination of the inflammatory reaction, in the induction of demyelination and neurodegeneration, and in remyelination ...
Xu Feng F Department of Infectious Diseases, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, - - 2014
Curcumin has remarkable anti-inflammatory and antioxidant properties. However, its effects on bacterium-induced acute lung injury (ALI) are not fully understood. To investigate the protective effects of curcumin on a mouse model of S. aureus-induced ALI. Mice were pretreated with i.p. injection of curcumin or vehicle 2h before S. aureus instillation. ...
Huen Sarah C SC Department of Medicine, Section of Nephrology, Yale University, PO Box 208029, New Haven, CT, USA, - - 2014
Acute ischemic kidney injury is a common complication in hospitalized patients. No treatment is yet available for augmenting kidney repair or preventing progressive kidney fibrosis. Animal models of acute kidney injury demonstrate that activation of the innate immune system plays a major role in the systemic response to ischemia/reperfusion injury. ...
Wang Xinzhi X Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR - - 2014
The study was designed to investigate the immune-modulatory effects of triptolide (TP) on CD4(+)T cell responses during liver injury. Previous studies have suggested that TP plays a critical role in modulating both innate and adaptive immune reactions, but its effects on the Th17/Treg balance during TP-induced liver injury remain unknown. ...
Roman Jesse J Departments of Medicine and Pharmacology & Toxicology, University of Louisville Health Sciences Center and Robley Rex VA Medical Center, Louisville, - - 2014
Although liver is the organ most often associated with the damaging effects of chronic alcohol abuse, other organs may also be affected. In the past decade, data emerged linking chronic alcohol intake to lung dysfunction. However, the mechanisms by which alcohol affects the lung remain incompletely elucidated. In this issue, ...
Lee Jae-Won JW Division of Nephrology, Department of Internal Medicine, Korea University Medical College, Seoul, Republic of Korea. Electronic address: - - 2014
The pathophysiology of ischemic acute kidney injury (AKI) is thought to include a complex interplay between vascular endothelial cell dysfunction, inflammation, and tubular cell damage. Several lines of evidence suggest a potential anti-inflammatory effect of vitamin D in various kidney injury models. In this study, we investigated the effect of ...
de Rivero Vaccari Juan Pablo JP Department of Neurological Surgery, The Miami Project to Cure Paralysis, Lois Pope LIFE Center, Miami, Florida, - - 2014
The inflammasome is an intracellular multiprotein complex involved in the activation of caspase-1 and the processing of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18. The inflammasome in the central nervous system (CNS) is involved in the generation of an innate immune inflammatory response through IL-1 cytokine release and in cell ...
O'Neill Stephen S MRC Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, - - 2014
Heat preconditioning induces heat-shock protein-70 upregulation and protects from renal ischemia/reperfusion injury. Kim et al. report that heat-shock protein-70 and regulatory T cells play a key role in protective heat preconditioning. This work reinforces the utility of inducing heat-shock protein-70 expression by pharmacological agents as a novel therapy for the ...
Entezari Maria M Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA ; The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY 11030, USA ; Department of Natural Science, LaGuardia Community College City University of New York, Queens, NY 11101, - - 2014
Prolonged exposure to hyperoxia results in acute lung injury (ALI), accompanied by a significant elevation in the levels of proinflammatory cytokines and leukocyte infiltration in the lungs. However, the mechanisms underlying hyperoxia-induced proinflammatory ALI remain to be elucidated. In this study, we investigated the role of the proinflammatory cytokine high ...
Di Yuanpu Peter YP Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Bridgeside Point, Pittsburgh, PA, 15219, USA, - - 2014
In animals, environmental exposure such as toxic chemicals and microorganisms or pathophysiological conditions in respiratory system could result in inflammatory response in their lungs. Bronchoalveolar lavage (BAL) is a procedure that can be used to collect samples from animal lungs to efficiently evaluate the immune response by examining both the ...
Sethi Sanjeev S Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Electronic address: - - 2013
Proliferative glomerulonephritis (GN) often is classified based on the pattern of injury. The pattern of injury does not reveal the underlying cause. New insights into the causes of proliferative GN suggest that determining the type of deposits is more likely to provide clues to the underlying cause than determining the ...
Rodriguesa Stephen F - - 2013
Ischemic stroke remains a leading cause of death worldwide. While the underlying causes of stroke remain poorly defined, brain inflammation appears to be a characteristic response to the vascular insult and there is growing evidence suggesting a cause-effect relationship between the inflammatory response and stroke-induced brain dysfunction and tissue injury. ...
An Chengrui C State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Fudan University, Shanghai 200032, - - 2013
Immune and inflammatory responses actively modulate the pathophysiological processes of acute brain injuries such as stroke. Soon after the onset of stroke, signals such as brain-derived antigens, danger-associated molecular patterns (DAMPs), cytokines, and chemokines are released from the injured brain into the systemic circulation. The injured brain also communicates with ...
Granja T T Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital; Eberhard-Karls University, Tübingen, - - 2013
Acute pulmonary inflammation during lung injury is initiated by the migration of neutrophils into the alveolar space. The severity of these inflammatory changes within the pulmonary tissue determines the severity of lung injury and ultimately patient outcome. Recent work has demonstrated that the guidance protein Semaphorin 7A propagates the infiltration ...
Yang Jixin J The Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Department of Pediatric Surgery, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH 43205, USA. Electronic address: - - 2014
Throughout the past 20 years, we have been investigating the potential therapeutic roles of heparin-binding EGF-like growth factor (HB-EGF), a member of the epidermal growth factor family, in various models of intestinal injury including necrotizing enterocolitis (NEC), intestinal ischemia/reperfusion (I/R) injury, and hemorrhagic shock and resuscitation (HS/R). Our studies have ...
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