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Wang Ruoxing R University of Southern Mississippi, United - - 2014
We have recently reported that mouse embryonic stem cells (mESCs) are deficient in expressing type-I interferons (IFNs) in response to viral infection and synthetic viral RNA analogs (J. Biol. Chem. 2013, 288: 15926-15936). Here, we report that mESCs are able to respond to type-I IFNs, express IFN-stimulated genes (ISGs), and ...
Liu Tian T Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, - - 2014
Huntington's Disease (HD) is the most common hereditary neurodegenerative diseases, in which the loss of striatal neuron caused by the aggregation of mutant Huntingtin protein (mHtt) is the main pathological feature. Our previous studies have demonstrated that human adipose stem cells (hASC) and its extract can slow down the progression ...
Welner Robert S RS Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02151, - - 2014
In this issue of Cell Stem Cell, Zhao et al. (2014) and Schürch et al. (2014) describe two new stem cell mechanisms underlying protective responses to infection. In response to inflammatory signals, HSPCs and MSCs produce cytokines that stimulate HSC mobilization and differentiation toward innate immune cells at the expense of adaptive ...
Tan Chen Sabrina CS Center of Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA; Division of NeuroVirology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA. Electronic address: - - 2014
JCV causes progressive multifocal leukoencephalopathy (PML) in immunocompromised patients. The mechanism of JCV reactivation and immunity in a transplanted immune system remains unclear. We prospectively studied 30 patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT), and collected blood and urine samples pre-HSCT, 3, 6, and 12-18 months after HSCT. Pre-HSCT, ...
Ye Haoyu H State key laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China; Guangdong Zhongsheng Pharmaceutical Co Ltd, Dongguan 440100, Guangdong, - - 2014
Bioactivity-guided isolation of the EtOAc extract of the stems of Millettia dielsiana Harms yielded two new together with nine known isoflavones. Their structures were elucidated by analysis of the spectroscopic data including 2D-NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide ...
Ferris Ryan A RA Equine Reproduction Laboratory, Colorado State University, Fort Collins Colorado USA. Electronic address: - - 2014
Current treatments for Persistent mating-induced endometritis such as uterine lavage and oxytocin therapy focus on aiding the uterus in removal of inflammatory products, but these treatments do not modulate the inciting inflammatory response. Biological treatments, such as autologous conditioned serum (ACS) and mesenchymal stem cells (MSCs), have been used in ...
Li Xiaoli X Cincinnati, Ohio, United States ; - - 2014
Aims: The study seeks to investigate the cause of hydrocephalus, and to identify therapeutic targets for prevention of hydrocephalus. Results: In this study, we show that inactivation of the Foxo3a gene in two mouse models of Fanconi anemia (FA), leads to the development of hydrocephalus in late embryonic stage and ...
Huet Olivier O †Intensive Care Unit, The Alfred Hospital, Melbourne, Victoria, - - 2014
Septic shock results from the dysregulation of the innate immune response following infection. Despite major advances in fundamental and clinical research, patients diagnosed with septic shock still have a poor prognostic outcome, with a mortality rate of up to 50%. Indeed, the reasons leading to septic shock are still poorly ...
Feng Yuliang Y Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Cardiovascular Institute, Southern Medical University, Guangzhou, China ; Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, United States of - - 2014
Mesenchymal stem cells (MSCs) have potential application for the treatment of ischemic heart diseases. Besides differentiation properties, MSCs protect ischemic cardiomyocytes by secretion of paracrine factors. In this study, we found exosomes enriched with miR-22 were secreted by MSCs following ischemic preconditioning (Exo(IPC)) and mobilized to cardiomyocytes where they reduced ...
Scheiner Zachary Z CIRM - California Institute for Regenerative Medicine, United - - 2013
Induced pluripotent stem cell (iPSC) technology offers the promise of immune-matched cellular therapies for a wide range of diseases and injuries. It is generally assumed that cells derived from autologous iPSCs will be immune privileged. However, there are reasons to question this assumption, including recent studies that have tested iPSC ...
Cope Elise C - - 2013
Infections during pregnancy have been associated with increased risks of neuropsychiatric disorders in offspring, although the underlying mechanisms have not been determined. Gallagher et al. (2013) show that maternal exposure to the infection-induced inflammatory cytokine IL-6 produces lasting effects on forebrain stem cell pools of offspring during embryogenesis and throughout life.
Malouf Camille - - 2013
Little is currently known about the developmental origins of the immune system and the lineage restriction processes that lead to its establishment. In this issue, Böiers et al. (2013) now demonstrate immune-restricted potential originating from the yolk sac even before the emergence of the first hematopoietic stem cells.
Turner Marc - - 2013
The ability to preselect the donor genotype of iPSC lines provides important opportunities for immune matching in cell therapy. Here we propose that an international assessment should be made of how immune incompatibility can best be managed and how a network of GMP HLA homozygous haplobanks could be operated.
Böiers Charlotta - - 2013
In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, ...
Boehm Anna-Marei - - 2013
Understanding aging and how it affects an organism's lifespan is a fundamental problem in biology. A hallmark of aging is stem cell senescence, the decline of functionality, and number of somatic stem cells, resulting in an impaired regenerative capacity and reduced tissue function. In addition, aging is characterized by profound ...
Dooley Dearbhaile - - 2013
The pharmacological support and stimulation of endogenous and transplanted neural stem cells (NSCs) is a major challenge in brain repair. Trauma to the central nervous system (CNS) results in a distinct inflammatory response caused by local and infiltrating immune cells. This makes NSC-supported regeneration difficult due to the presence of ...
Knight Jennifer M - - 2013
While psychosocial factors are known to affect cancer progression via biobehavioral pathways in many patient populations, these relationships remain largely unexplored in hematopoietic stem cell transplant (HCT) patients. The purpose of this paper is to critically review the literature regarding psychosocial and endocrine/immune aspects of HCT, with an emphasis on ...
Bosch Thomas C G - - 2013
Most epithelia in animals are colonized by microbial communities. These resident microbes influence fitness and thus ecologically important traits of their hosts, ultimately forming a metaorganism consisting of a multicellular host and a community of associated microorganisms. Recent discoveries in the cnidarian Hydra show that components of the innate immune ...
Mandana Mohyeddin Bonab - - 2013
BACKGROUND AND AIMS: Mesenchymal stem cells (MSC) are currently strong candidates for stem cell therapy. Cytokines have a profound effect on the resultant immune responses. This study aims to evaluate variations in the cytokine profile of multiple sclerosis patients treated with autologous MSC. METHODS: Twenty five patients received one dose ...
Quang Tran Hong - - 2013
Kalopanax pictus (Araliaceae) is a deciduous tree distributed in Korea, Japan, and China. The stem bark of K. pictus has been functionally used as a traditional crude drug for the treatment of various inflammatory diseases. In the present study, we describe the inhibitory effects of oleanane-type triterpenes and saponins isolated ...
Wang S-W - - 2013
The androgen receptor (AR) has a critical role in promoting androgen-dependent and -independent apoptosis in testicular cells. However, the molecular mechanisms that underlie the ligand-independent apoptosis, including the activity of AR in testicular stem cells, are not completely understood. In the present study, we generated induced pluripotent stem cells (iPSCs) ...
Wang Zhipeng Z Division of Infectious Diseases, Children's Hospital, Boston, Harvard Medical School, Boston, Massachusetts, - - 2013
Vibrio cholerae is an estuarine bacterium and an intestinal pathogen of humans that causes severe epidemic diarrhea. In the absence of adequate mammalian models in which to study the interaction of V. cholerae with the host intestinal innate immune system, we have implemented Drosophila melanogaster as a surrogate host. We ...
Vassiliadis Simon S Association of Greek Immunology Graduates (AGIG), Maroussi, Athens, - - 2013
Since the first Pharmacopoeia under the title "De Materia Medica," the importance of the utilization of plants and herbs has been an invaluable medicinal tool successfully employed for strengthening the immune system for combating a number of diseases in general, or assisting fertility and reproductive issues in particular. The beneficial ...
Pikman Regina - - 2012
Invasive fungal diseases are increasingly important opportunistic infections that are intimately linked to immune-suppression in the context of cytotoxic treatment of neoplastic diseases, stem cell and solid-organ transplantation, and primary immune deficiencies. Mortality rates remain high despite the availability of novel antifungals that are both safe and highly active in ...
Yang Gabsik - - 2012
ETHNOPHARMACOLOGICAL RELEVANCE: The stem bark of C. ovata has been used as a traditional herbal medicine for the treatment of various inflammatory diseases such as itching and scabies AIM OF THE STUDY: In the present study, we investigated the anti-AD effects of C. ovata stem bark on Dermatophagoides farinae-induced AD ...
O'Neill Luke A J - - 2012
A surprising link between innate immunity and nuclear reprogramming is reported by Lee et al.; this discovery may boost the efficiency of stem cell production.
Guo Yuan - - 2012
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, with increasing incidence and prevalence in the last one-half century. IBD patients suffer from autonomic vagal neuropathy and nerve dysfunction, with deficiency of acetylcholine in inflamed mucosa. Recent studies showed that death of enteric neuron in local tissue was induced during ...
Shuai Zhisheng - - 2012
A mathematical model for cholera is formulated that incorporates hyperinfectivity and temporary immunity using distributed delays. The basic reproduction number [Formula: see text] is defined and proved to give a sharp threshold that determines whether or not the disease dies out. The case of constant temporary immunity is further considered ...
Madhunapantula SubbaRao V - - 2012
Resistance to therapies develops rapidly for melanoma leading to more aggressive disease. Therefore, agents are needed that specifically inhibit proteins or pathways controlling the development of this disease, which can be combined, dependent on genes deregulated in a particular patient's tumors. This study shows that elevated sphingosine-1-phosphate (S-1-P) levels resulting ...
Larsson Dhana E - - 2012
Emetine and CGP-74514A has previously shown antitumor activity in neuroendocrine tumor cell lines. The aim of this study was to investigate the cytotoxic activity of the drugs in a three-dimensional model and to study if the mechanism of the cytotoxic activity was induction of apoptosis. An in vitro hollow fiber ...
Enomoto Noriyuki - - 2012
Allergen-specific CTL have a protective effect on allergic airway inflammation, a function thought to be mediated by cytokines, especially IFN-γ. However, the contribution of cytotoxic function to this protective effect has not been investigated. We examined the contribution of cytotoxic function to the therapeutic effect of allergen-specific CTL in allergic ...
Saleem Ahamed A The Cancer Institute of New Jersey, New Brunswick, New Jersey, - - 2012
Targeting multiple anti-apoptotic proteins is now possible with the small molecule BH3 domain mimetics such as ABT-737. Given recent studies demonstrating that autophagy is a resistance mechanism to multiple therapeutic agents in the setting of apoptotic inhibition, we hypothesized that hydroxychloroquine (HCQ), an anti-malarial drug that inhibits autophagy, will increase ...
Khanal Tilak - - 2012
Intestinal microflora (IM) is able to produce toxic and carcinogenic metabolites and induce more potent cytotoxicity against cells than non-metabolites. This study was performed to investigate the cytotoxic responses of geniposide (GS) and its metabolite and to determine the role of metabolism by IM in GS-induced cytotoxicity. Genipin (GP), a ...
Hsu Chia-Chun - - 2012
Melanoma is a lethal form of skin cancer that can metastasize rapidly. While surgery and radiation therapy provide palliative therapy for local tumor growth, systemic therapy is the mainstay of treatment for metastatic melanoma. However, limited chemotherapeutic agents are available for melanoma treatment. In this study, we investigated the anti-melanoma ...
Lovo Elena E Section of Immunobiology, Division of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Imperial College London, London W12 0NN, United - - 2012
How dendritic cells (DC) present Ag to cytotoxic T cells (CTL) without themselves being killed through contact-mediated cytotoxicity (so-called kiss of death) has proved to be controversial. Using mice deficient in serine protease inhibitor 6 (Spi6), we show that Spi6 protects DC from the kiss of death by inhibiting granzyme ...
Zhang Cheng Cheng - - 2012
Ample evidence indicated that hematopoietic stem cells (HSCs) receive signaling from infection or other immune responses to adjust their differentiation and self-renewal. More recent reports also suggested that, while the bone marrow microenvironment or niche may provide the immune privilege for HSCs, HSCs can present surface immune inhibitors per se ...
Wang Shih-Min - - 2012
Enterovirus 71 (EV71) is one of the most important causes of herpangina and hand, foot, and mouth disease. It can also cause severe complications of the central nervous system (CNS). Brain stem encephalitis with pulmonary edema is the severe complication that can lead to death. EV71 replicates in leukocytes, endothelial ...
Zheng Yuhuan Y Department of Lymphoma/Myeloma, Division of Cancer Medicine, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, - - 2012
NVP-BKM120 is a novel phosphatidylinositol 3-kinase (PI3K) inhibitor and is currently being investigated in phase I clinical trials in solid tumors. This study aimed to evaluate the therapeutic efficacy of BKM120 in multiple myeloma (MM). BKM120 induces cell growth inhibition and apoptosis in both MM cell lines and freshly isolated ...
Yan Jiaqi - - 2011
Sensitization of cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by luteolin has been suggested by in vitro studies. However, no in vivo experiment has been reported to validate the potentiation effect of luteolin on TRAIL's anticancer activity. In this report, we first confirmed that luteolin ...
Inkielewicz-Stepniak Iwona - - 2011
Fluoride intoxication and dexamethasone treatment produce deleterious effects in bone and brain. The aim of this study was to evaluate the effect of fluoride (F) and dexamethasone (Dex) co-exposure on oxidative stress and apoptosis in osteoblast-like MC3T3-E1 and hippocampal HT22 cell lines. Co-exposure to F and Dex resulted in a ...
Spotin Adel - - 2011
Cystic echinococcosis (hydatidosis) is a zoonotic helminthic disease of human and other intermediated hosts wherein infection is caused by the larval stages of tapeworm Echinococcus granulosus. Growth of the larval stage is formed throughout the internal organs, the liver and lung, causing their destruction. Important pathways are unknown about suppression ...
de Saint Basile Geneviève - - 2011
Hemophagocytic lymphohistiocytosis (HLH) manifests as the uncontrolled activation of T lymphocytes and macrophages infiltrating multiple organs. Molecular studies of individuals with HLH have demonstrated in most of these conditions a critical role of granule-dependent cytotoxic activity in the regulation of lymphocyte homeostasis, and have allowed the characterization of key effectors ...
Liu Shujing - - 2011
Norcantharidin (NCTD) has been reported to induce tumor cell apoptosis. However, the underlying mechanism behinds its antitumor effect remains elusive. We have previously shown that TR3 expression is significantly decreased in metastatic melanomas and involved in melanoma cell apoptosis. In this study, we showed that NCTD inhibited melanoma cell proliferation ...
Suffert Guillaume G Architecture et Réactivité de l'ARN, Institut de Biologie Moléculaire et Cellulaire du CNRS, Université de Strasbourg, Strasbourg, - - 2011
Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection. Previous studies reported that KSHV is able to inhibit apoptosis during latent infection; we thus tested the involvement of viral miRNAs in this process. We found that both HEK293 ...
Sutherland R M - - 2011
Adenoviral (Adv) vectors are widely used in both experimental and clinical trials for vaccination and gene therapy. Recombinant Adv can evoke potent innate immune responses and adaptive immune responses to encoded antigens. However, how Adv infection affects the response to subsequently encountered antigens is poorly understood. We show that intravenously ...
Dissanayake Dilan - - 2011
Mature dendritic cells (DCs) are crucial for the induction of adaptive immune responses and perturbed DC homeostasis can result in autoimmune disease. Either uncontrolled expansion or enhanced survival of DCs can result in a variety of autoimmune diseases in mouse models. In addition, increased maturation signals, through overexpression of surface ...
Hu Wenbin - - 2012
Chemoresistance of ovarian cancer has been previously attributed to the expression and activation of Bcl-2 family proteins. BH3-mimetic molecules possessing potential anticancer activity are able to inhibit antiapoptotic Bcl-2 family proteins. AT101 (R-(-)-gossypol), a natural BH3-mimetic molecule, has shown anti-tumor activity as a single agent and in combination with standard ...
Montes-Fonseca Silvia Lorena - - 2011
Cytotoxicity of carbon nanotubes (CNTs) is a prime concern for its use as antigen carriers. Here we evaluated the cytotoxic effect of unpurified (UP-CNTs), purified (P-CNTs), flourescein isothiocyanate functionalized (CNT-FITC) and Entamoeba histolytica-220 KDa lectin functionalized (CNT-L220) CNTs, in J774A macrophage (MOs) cell line. Cell viability and apoptosis were analyzed ...
Miah Mohammad Alam - - 2011
The cytokine inducible SH2-domain protein (CISH) is a well known STAT5 target gene, but its role in the immune system remains uncertain. In this study, we found that CISH is predominantly induced during dendritic cell (DC) development from mouse bone marrow (BM) cells, and plays a crucial role in type ...
Klymenko Tetyana - - 2011
Neuroblastoma is a common solid tumor of childhood and advanced disease carries a poor prognosis despite intensive multimodality therapy. Hypoxia is a common feature of solid tumors because of poorly organized tumor-induced neovasculature. Hypoxia is associated with advanced stage and poor outcome in a range of tumor types, and leads ...
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