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Thirunavukkarasu Shyamala S Faculty of Veterinary Science, University of Sydney , Camden , - - 2014
Abstract Mycobacteria have a complex cell wall with a high lipid content that confers unique advantages for bacterial survival in the hostile host environment, leading to long-term infection. There is a wealth of evidence suggesting the role cell wall-associated lipid antigens play at the host-pathogen interface by contributing to bacterial ...
Zhang Yan-Li YL Laboratory of Pathogenic Biology, Medical College, Qingdao University, 266071, Qingdao, Shandong, - - 2014
Clostridium sporogenes ATCC 3584 is an obligate anaerobe that has been reported to possess excellent tumour-targeting capacity. Here, we use Cl. sporogenes as a vector to deliver IL-12, a potent antitumour cytokine that bears numerous anti-tumour properties but that has limited clinical applications due to its strong toxicity when delivered ...
Petersen Troels R TR Malaghan Institute of Medical Research, Wellington, New Zealand; and - - 2014
This study tests the hypothesis that CD8α(+) DCs in the spleen of mice contain an immature precursor for functionally mature, "classical" cross-presenting CD8α(+) DCs. The lymphoid tissues contain a network of phenotypically distinct DCs with unique roles in surveillance and immunity. Splenic CD8α(+) DCs have been shown to exhibit a ...
Jagannathan Prasanna P Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94110, - - 2014
Although clinical immunity to malaria eventually develops among children living in endemic settings, the underlying immunologic mechanisms are not known. The Vδ2(+) subset of γδ T cells have intrinsic reactivity to malaria antigens, can mediate killing of Plasmodium falciparum merozoites, and expand markedly in vivo after malaria infection in previously ...
Canton Johnathan J *Program in Cell Biology, Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, M5G - - 2014
Macrophages respond to changes in environmental stimuli by assuming distinct functional phenotypes, a phenomenon referred to as macrophage polarization. We generated classically (M1) and alternatively polarized (M2) macrophages -two extremes of the polarization spectrum- to compare the properties of their phagosomes. Specifically, we analyzed the regulation of the luminal pH ...
Chereddy Kiran Kumar KK Université catholique de Louvain (UCL), Louvain Drug Research Institute (LDRI), Advanced Drug Delivery and Biomaterials, Avenue E. Mounier 73 bte box B1.73.12, 1200 Brussels, - - 2014
Wound treatment remains one of the most prevalent and economically burdensome healthcare issues in the world. Poly (lactic-co-glycolic acid) (PLGA) supplies lactate that accelerates neovascularization and promotes wound healing. LL37 is an endogenous human host defense peptide that modulates wound healing, angiogenesis and fights infection. Hence, we hypothesized that the ...
Rosenzweig Jason A JA Department of Biology and Center for Bionanotechnology and Environmental Research, Texas Southern University, 3100 Cleburne Street, Houston, TX, 77004, USA, - - 2014
As their environments change, microbes experience various threats and stressors, and in the hypercompetitive microbial world, dynamism and the ability to rapidly respond to such changes allow microbes to outcompete their nutrient-seeking neighbors. Viewed in that light, the very difference between microbial life and death depends on effective stress response ...
Hussain Mazhar M Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD 4072, - - 2014
Insects are the most successful group of animals on earth, owing this partly to their very effective immune responses to microbial invasion. These responses mainly include cellular and humoral responses as well as RNA interference (RNAi). Small non-coding RNAs (snRNAs) produced through RNAi are important molecules in the regulation of ...
Magenta Daniele D Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, - - 2014
Malaria remains one of the world's most common infectious diseases, being responsible for more deaths than any other communicable disease except tuberculosis. There is strong evidence that tumour necrosis factor α and interleukin-1β are important contributors to the systemic disease caused by the infection with Plasmodium falciparum. Circulating levels of ...
Lim Hun Jai HJ College of Pharmacy, Kangwon National University, Chunchon 200-701, - - 2014
The roots of Angelica decursiva Fr. Et Sav (Umbelliferae) have been frequently used in traditional medicine as anti-inflammatory, antitussive, analgesic agents and expectorant, especially for treating cough, asthma, bronchitis and upper respiratory tract infections. To establish the scientific rationale for the clinical use of Angelica decursiva and to identify new ...
Kim Jong-Hwan JH Herbal Medicine Research Division, Korea Food & Drug Administration, Seoul 363-700, - - 2014
To investigate the cytotoxicity, anti-inflammatory activity, and action mechanism of root bark extracts of Acanthopanax henryi. The hot methanol extract of the root bark of A. henryi was subjected to XAD-4 column chromatography eluting with a gradient of methanol in water. The cytotoxicity and anti-inflammatory effects of the MeOH fractions ...
Kaku Masato M Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. Electronic address: - - 2014
Previous studies have revealed that orthodontic force affects dental pulp via the rupture of blood vessels and vacuolization of pulp tissues. We hypothesized that pulp tissues express inflammatory cytokines and regulators of odontoclast differentiation after excess orthodontic force. The purpose of this study was to investigate the effects of tensile ...
Mesureur Jennifer J INSERM, U1047, Nîmes, - - 2014
In recent years the zebrafish has gained enormous attention in infection biology, and many protocols have been developed to study interaction of both human and fish pathogens, including viruses, fungi, and bacteria, with the host. Especially the extraordinary possibilities for live imaging of disease processes in the transparent embryos using ...
Barel Monique M INSERM 1151 Team 11, Unité de Pathogénie des Infections Systémiques, Université Paris Descartes, Bâtiment Leriche, 14 rue Maria Helena Vieira Da Silva CS61431, 75993, Paris cedex 14, France, - - 2014
Dissecting the interaction between bacterial and host proteins is fundamental in understanding pathogenesis. It is also very helpful for exploring new therapeutic approaches, either preventive or curative. Here, we describe different techniques, which allowed us to detect new molecules involved in the binding and infection of the bacterium Francisella tularensis, ...
McClure Ryan R Department of Microbiology, Boston University School of Medicine , Boston, MA , - - 2014
Toll-like receptor (TLR) signaling represents one of the best studied pathways to implement defense mechanisms against invading microbes in human being as well as in animals. TLRs respond to specific microbial ligands and to danger signals produced by the host during infection, and initiate downstream cascades that activate both innate ...
Silva-Bailão Mirelle Garcia MG Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil; Programa de Pós-Graduação em Patologia Molecular, Universidade de Brasília, Brasília, - - 2014
Iron is a micronutrient required by almost all living organisms, including fungi. Although this metal is abundant, its bioavailability is low either in aerobic environments or within mammalian hosts. As a consequence, pathogenic microorganisms evolved high affinity iron acquisition mechanisms which include the production and uptake of siderophores. Here we ...
Lezama-Dávila Claudio M CM Department of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH, 43210, - - 2014
Cutaneous leishmaniasis (CL) manifests as localized skin lesions, which lead to significant tissue destruction and disfigurement. In the Yucatan Peninsula, Mayan traditional healers use Pentalinon andrieuxii Muell.-Arg. (Apocynaceae) roots for the topical treatment of CL. Here, we studied the effect of P. andrieuxii root hexane extract (PARE) on the parasites and ...
Zhang Jing - - 2013
Stem cells from the apical papilla (SCAPs) are important for tooth root development and may be candidates for regenerative endodontic procedures involving immature teeth. The potential use of SCAPs for clinical applications requires a better understanding of their responses to bacterial challenge. We have investigated the effects of exposure of ...
Maserejian Nancy N - - 2013
Resins used in dental composites, derived from bisphenol-A (BPA), have been shown to alter immune cells. The objective of this study was to explore children's immune function changes in relation to resin composite treatment. We conducted secondary data analysis of the New England Children's Amalgam Trial immune function substudy (N = 59). ...
Jelali N - - 2013
The contribution of antioxidant defence systems in different tolerance to direct and bicarbonate-induced Fe deficiency was evaluated in two pea cultivars (Kelvedon, tolerant and Lincoln, susceptible). Fe deficiency enhanced lipid peroxidation and H2 O2 concentration in roots of both cultivars, particularly in the sensitive one grown under bicarbonate supply. The ...
Lim Hun Jai - - 2013
The root barks of Morus alba have been used in traditional medicine as an anti-inflammatory drug, especially for treating lung inflammatory disorders. To find new alternative agents against airway inflammation and to establish the scientific rationale of the herbal medicine in clinical use, the root barks of M. alba and ...
Yang Jingwen - - 2013
Our previous study identified the appearance of autophagy in developing tooth germs, and suggested its possible association with apoptosis in odontogenesis. Beclin1 was recently indicated to play a central role in bridging autophagy and apoptosis, and occupied a key position in the process of development. This study hypothesized that Beclin1 ...
A Shilpa Reddy - - 2013
Ozone has been successfully used in medical field since many years owing to its oxidizing property making it an excellent antimicrobial agent. Moreover its potent anti-inflammatory property along with favorable cellular and humoral immune response made ozone an effective therapeutic agent. Also its ability to arrest and reverse carious lesions ...
Tavares Warley Luciano Fonseca - - 2013
Root canal treatment typically involves cleaning and shaping procedures followed by treatment with antibacterial endodontic dressing between appointments and, ultimately, 3-dimensional,hermetic filling. Chlorhexidine (CHX) is effective as an irrigation solution and is used as an endodontic dressing. The aim of this study was to examine the influence of CHX on ...
Kim Seong Keun - - 2013
The fruit of the black raspberry (Rubus coreanus Miquel) has been employed in traditional medicine, and recent studies have demonstrated its measureable biological activities. However, the root of the black raspberry has not been studied. Therefore, in this study, we evaluated the anti-inflammatory and antibacterial properties of the root and ...
Li Wenjia - - 2013
ETHNOPHARMACOLOGICAL RELEVANCE: Aanthopanax senticosus (A. senticosus) Harms is a classical adaptogenic agent used in China. It has been applied as an analeptic aid to improve weakened physical status. However, little is known about the effects of A. senticosus on inflammatory disease processes. MATERIALS AND METHODS: Flies fed with standard cornmeal-yeast ...
Huang Xian-Ju - - 2013
Aim: Pendulous monkshood root is traditionally used for the treatment of several inflammatory pathologies such as rheumatisms, wounds, pain and tumors in China. In this study, the anti-inflammatory and anticancer activities and the mechanism of crude ethanol extract of pendulous monkshood root (EPMR) were evaluated and investigated in vitro. Materials ...
Dasc─âlu Ionela Teodora IT Department of Histology, University of Medicine and Pharmacy of Craiova, Romania; - - 2013
Angle Class III malocclusions are not so frequently met but they raise big problems of treatment. The analyzed case represents a 14-year-old patient that came to the dental consulting room with an Angle Class III malocclusion determined by the excess of the somatotropic pituitary hormone and a gingival hyperplasia more ...
Miki Yasuo - - 2012
We report a family of intravenous immunoglobulin (IVIg)-responsive X-linked Charcot-Marie-Tooth disease Type 1 (CMT1X) with a novel gap junction protein 1 mutation. Two of three siblings in the family complained of subacute motor and sensory impairment, and their symptoms improved after the administration of IVIg. Additional IVIg treatment also resulted ...
Kim Tae-Houn TH Division of Biological Sciences, Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, California 92093-0116, - - 2012
In a chemical genetics screen we identified the small-molecule [5-(3,4-dichlorophenyl)furan-2-yl]-piperidine-1-ylmethanethione (DFPM) that triggers rapid inhibition of early abscisic acid signal transduction via PHYTOALEXIN DEFICIENT4 (PAD4)- and ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1)-dependent immune signaling mechanisms. However, mechanisms upstream of EDS1 and PAD4 in DFPM-mediated signaling remain unknown. Here, we report that DFPM ...
Johnson Tyler A TA Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, United States. - - 2013
Extracts of four plant portions (roots, stems, leaves and flowers) of Urtica dioica (the stinging nettle) were prepared using accelerated solvent extraction (ASE) involving water, hexanes, methanol and dichloromethane. The extracts were evaluated for their anti-inflammatory and cytotoxic activities in an NF-κB luciferase and MTT assay using macrophage immune (RAW264.7) ...
Doshi Krunal - - 2012
Shyonaka (Oroxylum indicum Vent.; Bignoniaceae) root bark is one of the ingredients of dashamoola (a group of 10 roots), and is used for its anti-inflammatory and analgesic action in a number of compound formulations in Ayurveda. Ayurvedic Pharmacopoeia of India (API) recommends using the stem bark instead of root bark. ...
Grant Melissa - - 2012
SUMMARY This controlled longitudinal intervention study investigated changes in cytokines and biomarkers of bone and tissue metabolism within gingival crevicular fluid (GCF) from patients undergoing orthodontic treatment. GCF was collected on Periopaper™ strips (Oraflow Inc., USA) from 20 volunteers at baseline, before tooth extraction and appliance placement and then at ...
Xiao Haifang - - 2012
Eremurus chinensis Fedtch. (ECF) with nutritious roots, belonging to the genus of Eremurus, is a special species grown in China. However, the functional properties of ECF roots have not been intensely investigated. The antioxidant and anticancer effects of ethanol extracts from E. chinensis Fedtch. roots (ECFE) were evaluated in the ...
Tavares Warley Luciano Fonseca - - 2012
The use of calcium hydroxide is an effective step in killing bacteria that remain after cleaning and shaping procedures. It also induces hard-tissue formation and is effective for stopping inflammatory exudates. The aim of this study was to assay and to compare the influence of calcium hydroxide on periapical interstitial ...
Bundy David G - - 2012
With the use of Centers for Disease Control and Prevention (CDC) immunization recommendations as the gold standard, our objectives were to measure the accuracy ("is this child up-to-date on immunizations?") and usefulness ("is this child due for catch-up immunizations?") of the Healthcare Effectiveness Data and Information Set (HEDIS) childhood immunization ...
Moon Dong-Oh - - 2012
The anti-apoptotic oncogene K-RAS is hypothesized to increase the antioxidant status of cells, thereby protecting them from generation of reactive oxygen species (ROS). Therefore, we examined whether K-RAS overcomes hydrogen peroxide (H2O2)-mediated apoptosis in the human fetal prostate epithelial cell 267B1. In this study, we found that treatment of 267B1 ...
Taddei Maria Letizia - - 2012
Increased ROS (cellular reactive oxygen species) are characteristic of both fibrosis and tumour development. ROS induce the trans-differentiation to myofibroblasts, the activated form of fibroblasts able to promote cancer progression. Here, we report the role of ROS produced in response to dysfunctions of mitochondrial complex I, in fibroblast activation and ...
Lockett Angelia D - - 2012
α-1 Antitrypsin (A1AT) is a serpin with a major protective effect against cigarette smoke-induced emphysema development, and patients with mutations of the A1AT gene display a markedly increased risk for developing emphysema. We reported that A1AT protects lung endothelial cells from apoptosis and inhibits caspase-3 activity. It is not clear ...
Busacca Sara - - 2011
Therapeutic options for malignant pleural mesothelioma (MPM) are limited despite the increasing incidence globally. The vinca alkaloid, vinorelbine exhibits clinical activity, however, to date, treatment optimization has not been achieved using biomarkers. BRCA1 regulates sensitivity to microtubule poisons, however its role in regulating vinorelbine induced apoptosis in mesothelioma is unknown. ...
Jewell Christine M - - 2012
A mutation in the D-loop of the second zinc finger of the DNA-binding domain of the human glucocorticoid receptor (hGR), A458T (GR(dim)), has been suggested to be essential for dimerization and DNA binding of the GR, and genetically altered GR(dim) mice survive, whereas murine GR knockout mice die. Interestingly, thymocytes ...
Reikvam Håkon - - 2011
Heat shock proteins (HSPs) are molecular chaperones that assist proteins in their folding to native structures. HSPs are regarded as possible therapeutic targets in acute myeloid leukaemia (AML). We used bioinformatical approaches to characterize the HSP profile in AML cells from 75 consecutive patients, in addition to the effect of ...
Majors Brian S - - 2012
Recently, researchers have created novel fluorescent proteins by harnessing the somatic hypermutation ability of B cells. In this study, we examined if this approach could be used to evolve a non-fluorescent protein, namely the anti-apoptosis protein Bcl-x(L), using the Ramos B-cell line. After demonstrating that Ramos cells were capable of ...
Chaudhary Neelkamal N Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, - - 2012
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) alter epithelial cell (EC) interactions with multiple microbes, such that dysregulated inflammation and injury occur with airway colonization in people with cystic fibrosis (CF). Aspergillus fumigatus frequently colonizes CF airways, but it has been assumed to be an innocent saprophyte; its ...
Suzuki Nao - - 2011
Hematopoietic stem cells (HSCs) are maintained at a very low frequency in adult bone marrow (BM) under steady state conditions. However, it is not fully understood how homeostasis of BM HSCs is maintained. We attempted to identify a key molecule involved in the regulation of HSC number, a factor which ...
Elhasid Ronit - - 2011
Apoptosis related protein in TGF-β signaling pathway (ARTS/septin 4 isoform 2) hereforth referred to as ARTS, was originally found to promote apoptosis induced by TGF-β, but later was shown to promote apoptosis induced by a wide variety of apoptotic stimuli. In vivo and in vitro studies revealed that ARTS-induced apoptosis ...
Li Hua H University of Pittsburgh Cancer Institute, PA, - - 2011
Autophagy is often found in apoptosis-defective cancer cells and contributes to chemotherapy resistance. However, it is far from clear how the coordination of apoptosis and autophagy determines sensitivity of cancer cells to chemotherapy. Our recent study showed that Beclin 1, a key regulator of autophagy, is cleaved by caspase 8 ...
Chakraborty Jayashree Bagchi - - 2011
Alcoholic extract of Piper betle leaves (PBL) was recently found to induce apoptosis of chronic myeloid leukemia (CML) cells expressing wild type and mutated Bcr-Abl having imatinib resistance phenotype. Hydroxychavicol (HCH), a constituent of the alcoholic extract of PBL, was evaluated for anti-CML activity. Here we report that HCH and ...
Poulton Cathryn J - - 2011
We describe a syndrome of primary microcephaly with simplified gyral pattern in combination with severe infantile epileptic encephalopathy and early-onset permanent diabetes in two unrelated consanguineous families with at least three affected children. Linkage analysis revealed a region on chromosome 18 with a significant LOD score of 4.3. In this ...
Niu Feng-Nan - - 2011
Inflammation is an important contributing mechanism in ischemic brain injury. The current study elucidates a previously unexplored role of Fas ligand (FasL) in post-stroke inflammatory responses that is independent of its well-known effect in triggering apoptosis. Focal cerebral ischemia was induced for 2h by right middle cerebral artery occlusion (MCAO) ...
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