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Barthel Andrea A Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Strasse 8, Jena 07745, Germany - - 2014
Ecological immunology examines the adaptive responses of animals to pathogens in relation to other environmental factors and explores the consequences of trade-offs between investment in immune function and other life-history traits. Among species of herbivorous insects, diet breadth may vary greatly, with generalists consuming a wide variety of plant families ...
Liu Shuang S College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of - - 2014
Cadmium (Cd) is an important environmental pollutant present in soil, water, air, and food. Selenium (Se) can antagonize some metal element toxicity including Cd. To investigate the cytotoxicity of Cd and the protective effects of Se on bird immunocytes in vitro, chicken splenic lymphocytes with CdCl2 (10(-6) mol/L), Na2SeO3 (10(-7) mol/L), and ...
Yuan Damin D Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Department of Immunology, Medical College, Nantong University, Nantong, 226001, People's Republic of - - 2014
Somatostatins are peptide hormones that regulate diverse cellular processes, such as neurotransmission, cell proliferation, apoptosis, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. SSTR1 is a member of the superfamily of somatostatin receptors possessing seven-transmembrane segments. Aberrant expression of SSTR1 has been ...
Eskandari Mohammad Reza MR Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences , Zanjan , Iran - - 2014
Abstract 1. 5-Fluorouracil (5-FU) and its prodrug capecitabine are key chemotherapeutic agents in the treatment of many gastrointestinal tract adenocarcinomas. In addition to their beneficial antitumor effects, they also possess undesired cardiac toxicity. In the present study, we investigated the cytotoxic mechanisms of 5-FU and capecitabine in freshly isolated rat cardiomyocytes. ...
Hou Tingting T State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, - - 2014
Respiratory mitochondria undergo stochastic, intermittent bursts of superoxide production accompanied by transient depolarization of the mitochondrial membrane potential and reversible opening of the membrane permeability transition pore (mPTP). These discrete events were named "superoxide flashes", for the reactive oxygen species (ROS) signal involved, and "mitochondrial flashes (mitoflashes)", for the entirety ...
Jiang Yang Y aDepartment of Oral and Maxillofacial Surgery bCentral Laboratory, Peking University School and Hospital of Stomatology, Beijing, People's Republic of - - 2014
Salivary adenoid cystic carcinoma (SACC), which is one of the most common malignant tumors of the salivary glands, is associated with a poor long-term outcome. There are currently few therapeutic options for patients with SACC. Recent studies have shown the potential of the application of ultraviolet-C (UV-C) irradiation for the ...
Morissette Mathieu C MC Dept of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, - - 2014
Chronic obstructive pulmonary disease (COPD) is characterised by a state of chronic pulmonary inflammation punctuated by microbial exacerbations. Despite advances in treatment options, COPD remains difficult to manage. In this study, we investigated the potential of peroxisome proliferator-activated receptor (PPAR)γ activation as a new therapy against cigarette smoke-induced inflammation and ...
Guzeloglu-Kayisli O O Department of Obstetrics and Gynecology, the Ohio State University College of Medicine, Columbus, OH, - - 2014
Context: Despite the absence of progesterone receptor (PR) protein in human endometrial endothelial cells (HEECs), endometria of women receiving long-acting progestin-only contraceptives (LAPCs) displays reduced uterine blood flow, elevated reactive oxygen species (ROS) generation, increased angiogenesis and irregularly distributed, enlarged fragile microvessels resulting in abnormal uterine bleeding (AUB). Objective: We ...
Jeengar Manish Kumar MK National Institute of Pharmaceutical Education & Research, Balanagar, Hyderabad, 500037, A.P., - - 2014
The purpose of the present study is to evaluate the effect of emu oil on bioavailability of curcumin when co-administered and to evaluate the property that enhances the anti-inflammatory potential of curcumin. Oral bioavailability of curcumin in combination with emu oil was determined by measuring the plasma concentration of curcumin ...
Sessa Rosa R Rosa Sessa, Marisa Di Pietro, Simone Filardo, Department of Public Health and Infectious Diseases, "Sapienza" University, 00185 Rome, - - 2014
Atherosclerotic cardiovascular diseases, chronic inflammatory diseases of multifactorial etiology, are the leading cause of death worldwide. In the last decade, more infectious agents, labeled as "infectious burden", rather than any single pathogen, have been showed to contribute to the development of atherosclerosis through different mechanisms. Some microorganisms, such as Chlamydia ...
Capaldo Christopher T CT Epithelial Pathobiology and Mucosal Inflammation Research Unit, Dept. of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, - - 2014
Tight Junctions (TJs) are dynamic, mutiprotein intercellular adhesive contacts that provide a vital barrier function in epithelial tissues. TJs are remodeled during physiologic development and pathological mucosal inflammation, and differential expression of the claudin family of TJ proteins determines epithelial barrier properties. However, the molecular mechanisms involved in TJ remodeling ...
Thackray Larissa B LB Departments of - - 2014
Upon activation of Toll-like and RIG-I-like receptor signaling pathways, the transcription factor IRF5 translocates to the nucleus and induces antiviral immune programs. The recent discovery of a homozygous mutation in the immunoregulatory gene guanine exchange factor dedicator of cytokinesis 2 (Dock2(mu/mu)) in several Irf5(-/-) mouse colonies has complicated interpretation of ...
Yang Qiong Q Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, - - 2014
Cyclooxygenases (COXs) and their prostanoid products play important roles in a diverse range of physiological processes, including in the immune system. Here, we provide evidence that COX-1 is an essential regulator in early stages of B cell development. COX-1-deficient mice displayed systematic reduction in total B cells, which was attributed ...
Chen Jiann-Hwa JH Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan; Department of Emergency Medicine, Cathay General Hospital, Taipei - - 2014
Magnolol is isolated from the herb Magnolia officinalis, which has been demonstrated to exert pharmacological effects. Our aim was to investigate whether magnolol is able to act as an anti-inflammatory agent bring about neuroprotection using a global ischemic stroke model and to determine the mechanisms involved. Rats were treated with ...
Thomas Ac A University of Bristol, Bristol CardioVascular, Bristol, United - - 2014
Foam cell macrophage (FCM) formation is an early event in atherosclerosis that could contribute to fibrous cap development, although it has also been strongly implicated in cap rupture and thrombus formation. To understand this apparent paradox we compared the transcriptome of FCM and non-foamy macrophages (NFM) produced in vivo using ...
Inoue Tomoko - - 2014
Xanthogranulomatous inflammation is an uncommon form of chronic inflammation that is destructive to the normal tissue of affected organs. Although xanthogranulomatous endometritis and xanthogranulomatous salpingitis of the female genital tract has been described previously, to the best of our knowledge, this is the first report of xanthogranulomatous inflammation with infiltration ...
Behnen Martina M Institute for Medical Microbiology and Hygiene, University of Lübeck, D-23538 Lübeck, Germany; and - - 2014
Canonical neutrophil antimicrobial effector mechanisms, such as degranulation, production of reactive oxygen species, and release of neutrophil extracellular traps (NETs), can result in severe pathology. Activation of neutrophils through immune complexes (ICs) plays a central role in the pathogenesis of many autoimmune inflammatory diseases. In this study, we report that ...
Sampson Timothy R TR Department of Microbiology and Immunology, Microbiology and Molecular Genetics Program,Emory Vaccine Center, andYerkes National Primate Research Center, Emory University, Atlanta, GA - - 2014
Clustered, regularly interspaced, short palindromic repeats-CRISPR associated (CRISPR-Cas) systems defend bacteria against foreign nucleic acids, such as during bacteriophage infection and transformation, processes which cause envelope stress. It is unclear if these machineries enhance membrane integrity to combat this stress. Here, we show that the Cas9-dependent CRISPR-Cas system of the ...
Wang Wenxiang W Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China; Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, - - 2014
Twenty-one-day-old female Wistar rats were treated daily with orally administered soy isoflavones (SIFs) at concentrations of 50, 100, or 200mg/kg body weight from weaning until sexual maturity (3mo.), and ovarian follicle development was evaluated. At the end of the treatment period, the ultrastructure of the ovarian granulosa cells was examined ...
Adema C M CM Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: - - 2014
Gastropod immunology is informed importantly by the study of the frequent encounters snails endure with digeneans (digenetic trematodes). One of the hallmarks of gastropod-digenean associations is their specificity: any particular digenean parasite species is transmitted by a limited subset of snail taxa. We discuss the nature of this specificity, including ...
Gangoda L L Department of Biochemistry, La Trobe Institute of Molecular Science, La Trobe University, Melbourne, Victoria, - - 2014
Loss of function mutations in the Prkar1a gene are the cause of most cases of Carney complex disorder. Defects in Prkar1a are thought to cause hyper-activation of PKA signalling, which drives neoplastic transformation, and Prkar1a is therefore considered to be a tumour suppressor. Here we show that loss of Prkar1a ...
Huang Baoyu B Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao, 266071, - - 2014
Diverse alternative splicing isoforms play an important role in immune diversity and specificity. Their role in molluscan host-defense is however poorly understood. We characterized two alternative isoforms of tumor necrosis factor receptor-associated factor 3 (TRAF3) in the Pacific oyster, Crassostrea gigas, which were named CgTRAF3-S and CgTRAF3-L. An intron was ...
Cao Anthony T AT Departments of Microbiology and Immunology and Pathology, The University of Texas Medical Branch, Galveston, Texas, - - 2014
Tregs play a crucial role in the maintenance of intestinal immune homeostasis. However, significant numbers of Foxp3(+) Tregs accumulate in the inflamed lesions in experimental colitis and in IBD patients. Treg production of the proinflammatory cytokines IFN-γ and/or IL-17 may arguably explain their ineffectiveness in suppressing intestinal inflammation. However, it ...
Iijima Koji K Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN - - 2014
Humans are frequently exposed to various airborne allergens in the atmospheric environment. These allergens may trigger a complex network of immune responses in the airways, resulting in asthma and other chronic airway diseases. In this study, we investigated the immunological mechanisms involved in the pathological changes induced by chronic exposure ...
Gorlino Carolina V CV Centro de Investigación en Bioquímica Clínica e Inmunología, Consejo Nacional de Investigaciones Científica y Técnicas, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, X5000HUA, - - 2014
Although much is described about the molecules involved in neutrophil migration from circulation into tissues, less is known about the molecular mechanisms that regulate neutrophil entry into lymph nodes (LNs) draining a local inflammatory site. In this study, we investigated neutrophil migration toward LNs in a context of inflammation induced ...
Liesz Arthur A Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Institute for Stroke and Dementia Research, Klinikum der Universität München, Max-Lebsche-Platz 30, 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address: - - 2014
Stroke induces a profound neuroinflammatory reaction that leads to secondary cerebral tissue injury. Interleukin-10 (IL-10) is a key anti-inflammatory cytokine that is endogenously produced by immune cells and limits this inflammatory reaction. Previously, therapeutic administration of IL-10 has been shown to be neuroprotective in experimental stroke. However, the signaling pathways ...
Vittet Daniel D Inserm, U1036, Grenoble, F-38000 France, CEA, DSV, iRTSV, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, F-38000 France, Univ Grenoble Alpes, Grenoble, F-38000 France. Electronic address: - - 2014
The lymphatic vasculature plays an essential role in the maintenance of tissue interstitial fluid balance and in the immune response. After capture of fluids, proteins and antigens by lymphatic capillaries, lymphatic collecting vessels ensure lymph transport. An important component to avoid lymph backflow and to allow a unidirectional flow is ...
McMahon Taegan A TA 1] University of South Florida, Department of Integrative Biology, Tampa, Florida 33620, USA [2] University of Tampa, Department of Biology, Tampa, Florida 33606, USA - - 2014
Emerging fungal pathogens pose a greater threat to biodiversity than any other parasitic group, causing declines of many taxa, including bats, corals, bees, snakes and amphibians. Currently, there is little evidence that wild animals can acquire resistance to these pathogens. Batrachochytrium dendrobatidis is a pathogenic fungus implicated in the recent ...
Kang Bo B Department of Cardiothoracic Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Fengyang Road #415, Shanghai, 200003, - - 2014
The protective effect of hydrogen sulfide (H2S) against myocardial ischemia/reperfusion (IR) injury via anti-apoptotic signaling is well established, but the underlying mechanism remains unclear. Recently, miRNAs have been identified as important mediators of myocardial injury by regulating apoptosis-related genes. It was found in our previous preliminary study that microRNA-1 (miR-1) ...
Yang Jing-Yu JY Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, PR - - 2014
Alcohol abuse can result in significant alterations to the structure of the brain and ultimately to behavioral dysfunctions. Epidemiological studies have shown that alcoholism is closely associated with impaired memory and judgment. However, the degree of deficit (brain injury) depends on factors such as the age of onset, duration of ...
Guedouari H H Laboratoire Mitochondries, Métaux et Stress Oxydant, Institut Jacques Monod, Université Paris- Diderot/CNRS (UMR 7592), 15 rue Hélène Brion, 75013 Paris, - - 2014
Candia albicans is an opportunist pathogen responsible for a large spectrum of infections, from superficial mycosis to systemic diseases called candidiasis. Its ability to grow in various morphological forms, such as unicellular budding yeast, filamentous pseudohyphae and hyphae, contributes to its survival in the diverse microenvironments it encounters in the ...
Trautwein-Weidner K K Institute of Microbiology, ETH Zürich, Zürich, - - 2014
Interleukin-17 (IL-17)-mediated immunity has emerged as a crucial host defense mechanism against Candida albicans infections in mucosal tissues and the skin. The precise mechanism by which the IL-17 pathway prevents fungal outgrowth has not been clarified. Neutrophils are critical for limiting fungal dissemination and IL-17 is generally thought to act ...
Knoop K A KA Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, - - 2014
The delivery of luminal substances across the intestinal epithelium to the immune system is a critical event in immune surveillance, resulting in tolerance to dietary antigens and immunity to pathogens. How this process is regulated is largely unknown. Recently goblet cell-associated antigen passages (GAPs) were identified as a pathway delivering ...
Wang Yan Y Department of Microbiology and Immunology; Geisel School of Medicine; Dartmouth College; Lebanon, NH - - 2014
Tolerance established by host-commensal interactions regulates host immunity at both local mucosal and systemic levels. The intestinal commensal strain Bacteroides fragilis elicits immune tolerance, at least in part, via the expression capsular polysaccharide A (PSA). How such niche-specific commensal microbial elements regulate extra-intestinal immune responses, as in the brain, remains ...
Stephenson Erin E Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Health Medical Research Centre, Room 187, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, - - 2014
MRI and histological studies have shown global alterations in iron levels in the brains of patients with multiple sclerosis (MS), including increases in the iron stored by macrophages and microglia. Excessive free iron can be toxic, and accumulation of iron in MS has generally been thought to be detrimental. However, ...
Arroyo Juan J Department of Physiology and Developmental Biology, Brigham Young University , Provo, UT - - 2014
Abstract Increased trophoblast apoptosis has been implicated in pregnancies complicated by fetal growth restriction and preeclampsia (EC). We investigated placenta growth factor (PLGF) signaling during trophoblast apoptosis in culture and X-linked inhibitor of apoptosis protein (XIAP) and apoptosis inducible factor (AIF) in the preeclamptic placenta at term was determined. Primary ...
Sureda Antoni A University of Balearic - - 2014
Objective: Scuba diving, characterized by hyperoxia and hyperbaria, could increase reactive oxygen species production which acts as signalling molecules to induce adaptation against oxidative stress. The aim was to study the effects of scuba diving immersion on neutrophil inflammatory response, the induction of oxidative damage and the NO synthesis. Design: ...
Kumawat Kuldeep K University of Groningen, Groningen Research Institute for Asthma and COPD, Department of Molecular Pharmacology , A. Deusinglaan 1, 9713 AV Groningen , The Netherlands +31 50 363 8177 ; +31 50 363 6908 ; - - 2014
Introduction: Pathological alteration in the airway structure, termed as airway remodeling, is a hallmark feature of individuals with asthma and has been described to negatively impact lung function in asthmatics. Recent studies have raised considerable interest in the regulatory role of β-catenin in remodeling asthmatic airways. The WNT/β-catenin signaling pathway ...
Brunner Franziska S FS School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK Experimental Ecology, Institute of Integrative Biology, ETH Zürich, Universitätsstrasse 16, 8092 Zürich, - - 2014
Parasites infect hosts non-randomly as genotypes of hosts vary in susceptibility to the same genotypes of parasites, but this specificity may be modulated by environmental factors such as nutrition. Nutrition plays an important role for any physiological investment. As immune responses are costly, resource limitation should negatively affect immunity through ...
Botts Michael R MR Department of Biomolecular - - 2014
Among pathogenic environmental fungi, spores are thought to be infectious particles that germinate in the host to cause disease. The meningoencephalitis-causing yeast Cryptococcus neoformans is found ubiquitously in the environment and sporulates in response to nutrient limitation. While the yeast form has been studied extensively, relatively little is known about ...
Vachharajani Vidula T VT Anesthesiology, Internal Medicine, and Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA - - 2014
Mechanism-based sepsis treatments are unavailable, and their incidence is rising worldwide. Deaths occur during the early acute phase of hyperinflammation or subsequent postacute hypoinflammatory phase with sustained organ failure. The acute sepsis phase shifts rapidly, and multiple attempts to treat early excessive inflammation have uniformly failed. We reported in a ...
Jolly S S Université de Reims Champagne-Ardenne, UMR-I02 SEBIO, BP 1039, 51687, Reims Cedex 2, France, - - 2014
Aluminium is used in diverse anthropogenic processes at the origin of pollution events in aquatic ecosystems. In the Champagne region (France), high concentrations of aluminium (Al) are detected due to vine-growing practices. In fish, little is known about the possible immune-related effects at relevant environmental concentrations. The present study analyzes ...
Zhang Xiaolei X Department of Cardiology, Affiliated Hospital of Jiangsu - - 2014
Aim: It has been reported that oxidized low-density lipoprotein (oxLDL) forms a stable and non-dissociable complex with β2-glycoprotein I (β2GPI) and that IgG anti-β2GPI autoantibodies are able to recognize this complex, thus facilitating macrophage-derived foam cell formation in patients with antiphospholipid syndrome (APS). However, the immunopathological mechanisms of oxLDL/β2GPI complexes ...
Park Youngjin Y Department of Bioresource Sciences, Andong National University, Andong 760-749, Republic of - - 2014
Integrins are cell surface heterodimeric proteins interacting with the extracellular matrix and mediating environmental signals through cell membranes. A full-length cDNA sequence of the integrin β1 subunit gene (HaITGb1) was cloned from the Oriental tobacco budworm, Helicoverpa assulta, and analyzed for its physiological role in both immune response and development. ...
Need Eleanor F EF Discipline of Surgery, School of Medicine, The Queen Elizabeth Hospital, University of Adelaide, DX465702, 28 Woodville Road, Woodville, SA, 5011, - - 2014
It is well established that the development and homeostasis of the mammary gland are highly dependent upon the actions of ovarian hormones progesterone and estrogen, as well as the availability of prolactin for the pregnant and lactating gland. More recently it has become apparent that immune system cells and cytokines ...
Escande Carlos C Department of Anesthesia, Mayo Clinic, Rochester, MN, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Institut Pasteur Montevideo, Montevideo, - - 2014
Chronic obesity leads to inflammation, tissue dysfunction, and cellular senescence. It was proposed that cellular senescence during obesity and aging drives inflammation and dysfunction. Consistent with this, clearance of senescent cells increases healthspan in progeroid mice. Here, we show that the protein Deleted in Breast Cancer-1 (DBC1) regulates cellular senescence ...
Meng Fanyong F University of Chicago, Medicine, Chicago, Illinois, United States ; - - 2014
Background: Reversible changes in lung microstructure accompany lung inflammation, although alterations in tissue micromechanics and their impact in inflammation remains unknown. This study investigated changes in extracellular matrix (ECM) remodeling and tissue stiffness in the model of LPS-induced inflammation and examined a role of lipoxin analog eLXA4, in reduction of ...
Wang Ke K Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong - - 2014
Neuroinflammation underlies a wide variety of pathological processes in the central nerve system (CNS). Although previous experimental and clinical studies indicate that activation of neuroinflammatory signaling occurs early in glaucoma, the mechanisms controlling microglia activation are still poorly defined. In the present study, we investigated the role of the chemokine ...
Hsia B J BJ Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, - - 2014
Allergic asthma is thought to stem largely from maladaptive T helper 2 (Th2) responses to inhaled allergens, which in turn lead to airway eosinophilia and airway hyperresponsiveness (AHR). However, many individuals with asthma have airway inflammation that is predominantly neutrophilic and resistant to treatment with inhaled glucocorticoids. An improved understanding ...
Fan Hong-Bo HB Key Lab of Stem Cell Biology & State Key Lab for Medical Genomics & Lab of Development and Diseases, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, - - 2014
Neutrophils play critical roles in vertebrate innate immune responses. As an emerging regulator in normal myelopoiesis, the precise roles of microRNA in the development of neutrophils have yet to be clarified. Using zinc-finger nucleases, we have successfully generated heritable mutations in miR-142a and miR-142b, and showed that hematopoietic-specific miR-142-3p is ...
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