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Wang Shunchang S Department of Life Science, Huainan Normal University, Huainan 232001, China. Electronic address: - - 2014
Apoptosis is one of the main cellular processes in responses to arsenic, the well known environmental carcinogen. By using the nematode Caenorhabditis elegans as an in vivo model, we found that insulin-like growth factor-1 networks and their target protein DAF-16/FOXO, known as key regulators of energy metabolism and growth, played ...
Li Ruijin R Institute of Environmental Science, Shanxi University, Taiyuan, PR China; State Environmental Protection Key Laboratory of Efficient Utilization of Coal Waste Resources, Shanxi University, Taiyuan, PR - - 2014
Exposure to sulfur dioxide (SO2) increases asthma risk. Inflammatory and immune responses are typical in asthma disease. The exact effect of SO2 on modulation of the inflammatory and immune responses in asthmatic rats remains unclear. Here we sought to investigate the molecular mechanisms underlying the NF-κB inflammatory pathway and the ...
Barthel Andrea A Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Strasse 8, Jena 07745, Germany - - 2014
Ecological immunology examines the adaptive responses of animals to pathogens in relation to other environmental factors and explores the consequences of trade-offs between investment in immune function and other life-history traits. Among species of herbivorous insects, diet breadth may vary greatly, with generalists consuming a wide variety of plant families ...
Barclay Victoria C VC Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania - - 2014
Abstract Host immunity plays an important role in the evolution of pathogen virulence and disease emergence. There is increasing theoretical and empirical evidence that enhanced immunity through vaccination may have the unfortunate side effect of selecting for more virulent parasites, but the effect of host immune suppression on pathogen evolution ...
Gay Nicholas J NJ Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, - - 2014
Signal transduction by the Toll-like receptors (TLRs) is central to host defence against many pathogenic microorganisms and also underlies a large burden of human disease. Thus, the mechanisms and regulation of signalling by TLRs are of considerable interest. In this Review, we discuss the molecular basis for the recognition of ...
Lotti Torello T University of Rome "G. Marconi", Rome, Italy, - - 2014
Vitiligo is an acquired depigmentary skin disorder of unknown origin characterized by well-demarcated, white macules of varying size and distribution. Despite relevant new research and progresses, why melanocytes disappear to induce the characteristic achromic lesions of vitiligo is not fully understood. In spite of recent findings implicating genetic, immune and ...
de Sousa Rafael T RT University of Sao Paulo, Institute and Department of Psychiatry, Laboratory of Neuroscience, LIM-27, Faculty of Medicine , Paulo Rua Ovidio Pires de Campos 785, São Paulo, SP , - - 2014
Introduction: Bipolar disorder (BPD) is a severe illness with few treatments available. Understanding BPD pathophysiology and identifying potential relevant targets could prove useful for developing new treatments. Remarkably, subtle impairments of mitochondrial function may play an important role in BPD pathophysiology. Areas covered: This article focuses on human studies and ...
Singh Varsha V Johns - - 2014
Probiotics, including Lactobacilli, are commensal bacteria that have been used in clinical trials and experimental models for the prevention and treatment of diarrheal disorders. Our previous studies have shown that Lactobacillus acidophilus (LA) and its culture supernatant (CS) stimulated Cl(-)/HCO3 (-) exchange activity, acutely via an increase in the surface ...
Pathak Manisha M Parasitology Division, CSIR-Central Drug Research Institute, BS 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, - - 2014
Wolbachia is an endosymbiotic bacterium of filarial nematode Brugia malayi. The symbiotic relationship between Wolbachia and its filarial host is dependent on some interactions between the proteins of both organisms. However, very little is known about Wolbachia proteins that are involved in inflammatory pathology of the host during lymphatic filariasis. ...
Zhang Yongqiang Y Department of Anesthesiology, The First Affiliated Hospital of XinXiang Medical College, WeiHui, HeNan Province, 453100,, - - 2014
Ketamine is a commonly used pediatric anesthetic, but it might affect development, or even induce neurotoxicity in the neonatal brain. We have used an in vivo neonatal mouse model to induce ketamine-related neurotoxicity in the hippocampus, and found that miR-34c, a microRNA associated with pathogenesis of Alzheimer's disease, was significantly ...
Wei Xue X Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou 730000, - - 2014
Abstract Context and objective: Recent reports have highlighted the relationship between cadmium (Cd) and autophagy, however, whether Cd can activate mitophagy remains enigmatic. This study aims to investigate the effects of Cd on mitophagy and its potential mechanism. Methods: Mice were intraperitoneally injected with Cd for 3 days. Mitochondrial membrane ...
Ochiai Sotaro S Malaghan Institute of Medical Research, Wellington 6012, New Zealand; University of Otago, Wellington 6021, New - - 2014
The cytokine thymic stromal lymphopoietin (TSLP) is produced by epithelia exposed to the contact sensitizer dibutyl phthalate (DBP), and it is critical for the induction of Th2 immune responses by DBP-FITC. TSLP is thought to act on dendritic cells (DC), but the precise DC subsets involved in the response to ...
Xu Xuefeng X National Clinical Research Centre for Respiratory Medicine, Beijing Hospital, Beijing 100730, - - 2014
Idiopathic pulmonary fibrosis (IPF) is characterized by hyperplasia of type II alveolar epithelial cells, aggregation of activated (myo)fibroblasts and excessive deposition of extracellular matrix, which will ultimately lead to lung architecture destruction with no proven effective therapies. Despite a significant increase in our understanding on the etiology and pathogenesis of ...
Lee Jong Seok JS 1 Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University , Atlanta, Georgia - - 2014
Formalin-inactivated respiratory syncytial virus (FI-RSV) immunization is known to cause severe pulmonary inflammatory disease after subsequent RSV infection. Ginseng has been used in humans for thousands of years due to its potential health benefits. We investigated whether ginseng would have immune modulating effects on RSV infection in mice previously immunized ...
Dong YiLong Y The School of Medicine, Yunnan University, Kunming, Yunnan, China P.R, - - 2014
Our previous studies have demonstrated that phytoestrogen α-zearalanol (α-ZAL) possesses potential benefits in alleviating cell apoptotic death just like estrogen. However, the underlying mechanism is not fully understood. This study was designed to test the hypothesis that the neuroprotective effect of α-ZAL is mediated by estrogen receptor (ER) since α-ZAL ...
Kaiser Steffen S Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, 55128 Mainz, - - 2014
RNA can function as a pathogen-associated molecular pattern (PAMP) whose recognition by the innate immune system alerts the body to an impending microbial infection. The recognition of tRNA as either self or nonself RNA by TLR7 depends on its modification patterns. In particular, it is known that the presence of ...
Machado M V MV Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA Gastroenterology Department, Hospital de Santa Maria, CHLN, Lisbon, - - 2014
Caspase-2 is an initiator caspase involved in multiple apoptotic pathways, particularly in response to specific intracellular stressors (eg, DNA damage, ER stress). We recently reported that caspase-2 was pivotal for the induction of cell death triggered by excessive intracellular accumulation of long-chain fatty acids, a response known as lipoapoptosis. The ...
Chavez Carolina C Instituto de Biotecnología, Universidad Nacional Autónoma de México. Apdo. Postal 510-3, Cuernavaca 62250, Morelos, Mexico. Electronic address: - - 2014
Nitric oxide (NO) produced by the nitric oxide synthase (NOS) enzyme is a reactive oxygen molecule widely considered as important participant in the immune system of different organisms to confront microbial infections. In insects the NO molecule has also been implicated in immune response against microbial pathogens. Bacillus thuringiensis (Bt) ...
Wäster P P Divison of Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Dermatology and Venereology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, - - 2014
Ultraviolet (UV) radiation constitutes an important risk factor for malignant melanoma, but the wavelength responsible for the initiation of this disease is not fully elucidated. Solar UV induces multiple signaling pathways that are critical for initiation of apoptotic cell death as a cellular defense against malignant transformation. To evaluate the ...
Metushi Imir G IG Department of Pharmacology and Toxicology, Faculty of Medicine - - 2014
Abstract Amodiaquine (AQ) treatment is associated with a high incidence of idiosyncratic drug-induced liver injury (IDILI) and agranulocytosis. Evidence suggests that AQ-induced IDILI is immune mediated. A significant impediment to mechanistic studies of IDILI is the lack of valid animal models. This study reports the first animal model of IDILI ...
Kostadinova Feodora F Biochemical Pharmacology, Department of Biology, University of Konstanz , - - 2014
Glucocorticoids (GC) are steroid hormones with important implications in the treatment of various inflammatory and autoimmune diseases. At the same time GC are known to have numerous side-effects. Endogenous GC are predominantly produced by the adrenal glands, and adrenal-derived GC serve important functions in the regulation of development, metabolism, and ...
A Priyanka - - 2014
Abstract Excessive expansion of white adipose tissue leads to hypoxia which is considered as a key factor responsible for adipose tissue dysfunction in obesity. Hypoxia induces inflammation, insulin resistance, and other obesity related complications. So the hypoxia-signalling pathway is expected to provide a new target for the treatment of obesity-associated ...
Bozza Silvia S Department of Experimental Medicine, University of Perugia, Perugia 06132, - - 2014
The long pentraxin 3 (PTX3) modulates different effector pathways involved in innate resistance to Aspergillus fumigatus, including complement activation or promotion of phagocytosis by interacting with FcγRs. However, whether and how TLRs modulate PTX3 mediates antifungal resistance is not known. In this study, we demonstrate that PTX3 binds myeloid differentiation ...
Johnson Bobby L - - 2014
In response to infection and trauma, exquisite control of the innate inflammatory response is necessary to promote an anti-microbial response and minimize tissue injury. Over the course of the host response, activated leukocytes are essential for the initial response and can later become unresponsive or undergo apoptosis. Leukocytes, along the ...
Liu Shuang S College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of - - 2014
Cadmium (Cd) is an important environmental pollutant present in soil, water, air, and food. Selenium (Se) can antagonize some metal element toxicity including Cd. To investigate the cytotoxicity of Cd and the protective effects of Se on bird immunocytes in vitro, chicken splenic lymphocytes with CdCl2 (10(-6) mol/L), Na2SeO3 (10(-7) mol/L), and ...
Yuan Damin D Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Department of Immunology, Medical College, Nantong University, Nantong, 226001, People's Republic of - - 2014
Somatostatins are peptide hormones that regulate diverse cellular processes, such as neurotransmission, cell proliferation, apoptosis, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. SSTR1 is a member of the superfamily of somatostatin receptors possessing seven-transmembrane segments. Aberrant expression of SSTR1 has been ...
Eskandari Mohammad Reza MR Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences , Zanjan , Iran - - 2014
Abstract 1. 5-Fluorouracil (5-FU) and its prodrug capecitabine are key chemotherapeutic agents in the treatment of many gastrointestinal tract adenocarcinomas. In addition to their beneficial antitumor effects, they also possess undesired cardiac toxicity. In the present study, we investigated the cytotoxic mechanisms of 5-FU and capecitabine in freshly isolated rat cardiomyocytes. ...
Hou Tingting T State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, - - 2014
Respiratory mitochondria undergo stochastic, intermittent bursts of superoxide production accompanied by transient depolarization of the mitochondrial membrane potential and reversible opening of the membrane permeability transition pore (mPTP). These discrete events were named "superoxide flashes", for the reactive oxygen species (ROS) signal involved, and "mitochondrial flashes (mitoflashes)", for the entirety ...
Endele Max M Department of Biosystems Science and Engineering (D-BSSE), ETH Zurich, Mattenstrasse 26, 4058 Basel, - - 2014
Hematopoiesis is the cumulative consequence of finely tuned signaling pathways activated through extrinsic factors, such as local niche signals and systemic hematopoietic cytokines. Whether extrinsic factors actively instruct the lineage choice of hematopoietic stem and progenitor cells or are only selectively allowing survival and proliferation of already intrinsically lineage-committed cells ...
Xia Xiaomin X Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, People's Republic of - - 2014
This study investigated the protective effect of α-lipoic acid (LA) on lipopolysaccharide (LPS)/d-galactosamine (d-GalN)-induced fulminant hepatic failure in mice. First, we found that LA markedly reduced LPS/d-GalN-induced increases in serum ALT and AST activities, which were supplemented with histopathological examination, suggested that LA has a protective effect on this model ...
Fossati-Jimack Liliane L Centre for Complement and Inflammation Research, College London, London, United - - 2014
A role for complement, particularly the classical pathway, in the regulation of immune responses is well documented. Deficiencies in C1q or C4 predispose to autoimmunity, whilst deficiency in C3 affects suppression of contact sensitisation and generation of oral tolerance. Complement components including C3 have been shown to be required for ...
Jiang Yang Y aDepartment of Oral and Maxillofacial Surgery bCentral Laboratory, Peking University School and Hospital of Stomatology, Beijing, People's Republic of - - 2014
Salivary adenoid cystic carcinoma (SACC), which is one of the most common malignant tumors of the salivary glands, is associated with a poor long-term outcome. There are currently few therapeutic options for patients with SACC. Recent studies have shown the potential of the application of ultraviolet-C (UV-C) irradiation for the ...
Morissette Mathieu C MC Dept of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, - - 2014
Chronic obstructive pulmonary disease (COPD) is characterised by a state of chronic pulmonary inflammation punctuated by microbial exacerbations. Despite advances in treatment options, COPD remains difficult to manage. In this study, we investigated the potential of peroxisome proliferator-activated receptor (PPAR)γ activation as a new therapy against cigarette smoke-induced inflammation and ...
De Haro Joaquin J Angiology and Vascular Surgery Department, Getafe University Hospital, Getafe, Madrid, Spain. Electronic address: - - 2014
This study assessed the effect of cellular and humoral autoimmune response inhibition after immunization with β2-glycoprotein I (β2-GPI) and the effect of immunomodulation with interleukin (IL)-2 and IL-10 in the development of early atherosclerotic vascular lesion in a murine model. Atherosclerosis is increasingly considered a chronic inflammatory disease with pathogenic ...
Guzeloglu-Kayisli O O Department of Obstetrics and Gynecology, the Ohio State University College of Medicine, Columbus, OH, - - 2014
Context: Despite the absence of progesterone receptor (PR) protein in human endometrial endothelial cells (HEECs), endometria of women receiving long-acting progestin-only contraceptives (LAPCs) displays reduced uterine blood flow, elevated reactive oxygen species (ROS) generation, increased angiogenesis and irregularly distributed, enlarged fragile microvessels resulting in abnormal uterine bleeding (AUB). Objective: We ...
Jeengar Manish Kumar MK National Institute of Pharmaceutical Education & Research, Balanagar, Hyderabad, 500037, A.P., - - 2014
The purpose of the present study is to evaluate the effect of emu oil on bioavailability of curcumin when co-administered and to evaluate the property that enhances the anti-inflammatory potential of curcumin. Oral bioavailability of curcumin in combination with emu oil was determined by measuring the plasma concentration of curcumin ...
Capaldo Christopher T CT Epithelial Pathobiology and Mucosal Inflammation Research Unit, Dept. of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, - - 2014
Tight Junctions (TJs) are dynamic, mutiprotein intercellular adhesive contacts that provide a vital barrier function in epithelial tissues. TJs are remodeled during physiologic development and pathological mucosal inflammation, and differential expression of the claudin family of TJ proteins determines epithelial barrier properties. However, the molecular mechanisms involved in TJ remodeling ...
Thackray Larissa B LB Departments of - - 2014
Upon activation of Toll-like and RIG-I-like receptor signaling pathways, the transcription factor IRF5 translocates to the nucleus and induces antiviral immune programs. The recent discovery of a homozygous mutation in the immunoregulatory gene guanine exchange factor dedicator of cytokinesis 2 (Dock2(mu/mu)) in several Irf5(-/-) mouse colonies has complicated interpretation of ...
Yang Qiong Q Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, - - 2014
Cyclooxygenases (COXs) and their prostanoid products play important roles in a diverse range of physiological processes, including in the immune system. Here, we provide evidence that COX-1 is an essential regulator in early stages of B cell development. COX-1-deficient mice displayed systematic reduction in total B cells, which was attributed ...
Chen Jiann-Hwa JH Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan; Department of Emergency Medicine, Cathay General Hospital, Taipei - - 2014
Magnolol is isolated from the herb Magnolia officinalis, which has been demonstrated to exert pharmacological effects. Our aim was to investigate whether magnolol is able to act as an anti-inflammatory agent bring about neuroprotection using a global ischemic stroke model and to determine the mechanisms involved. Rats were treated with ...
Agmon-Levin Nancy N Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 52621, Israel; Sackler Medical School, Tel Aviv University, - - 2014
Hepatitis-B vaccine (HBVv) can prevent HBV-infection and associated liver diseases. However, concerns regarding its safety, particularly among patients with autoimmune diseases (i.e. SLE) were raised. Moreover, the aluminum adjuvant in HBVv was related to immune mediated adverse events. Therefore, we examined the effects of immunization with HBVv or alum on ...
Sessa Rosa R Rosa Sessa, Marisa Di Pietro, Simone Filardo, Department of Public Health and Infectious Diseases, "Sapienza" University, 00185 Rome, - - 2014
Atherosclerotic cardiovascular diseases, chronic inflammatory diseases of multifactorial etiology, are the leading cause of death worldwide. In the last decade, more infectious agents, labeled as "infectious burden", rather than any single pathogen, have been showed to contribute to the development of atherosclerosis through different mechanisms. Some microorganisms, such as Chlamydia ...
Thomas Ac A University of Bristol, Bristol CardioVascular, Bristol, United - - 2014
Foam cell macrophage (FCM) formation is an early event in atherosclerosis that could contribute to fibrous cap development, although it has also been strongly implicated in cap rupture and thrombus formation. To understand this apparent paradox we compared the transcriptome of FCM and non-foamy macrophages (NFM) produced in vivo using ...
Inoue Tomoko - - 2014
Xanthogranulomatous inflammation is an uncommon form of chronic inflammation that is destructive to the normal tissue of affected organs. Although xanthogranulomatous endometritis and xanthogranulomatous salpingitis of the female genital tract has been described previously, to the best of our knowledge, this is the first report of xanthogranulomatous inflammation with infiltration ...
Behnen Martina M Institute for Medical Microbiology and Hygiene, University of Lübeck, D-23538 Lübeck, Germany; and - - 2014
Canonical neutrophil antimicrobial effector mechanisms, such as degranulation, production of reactive oxygen species, and release of neutrophil extracellular traps (NETs), can result in severe pathology. Activation of neutrophils through immune complexes (ICs) plays a central role in the pathogenesis of many autoimmune inflammatory diseases. In this study, we report that ...
Sampson Timothy R TR Department of Microbiology and Immunology, Microbiology and Molecular Genetics Program,Emory Vaccine Center, andYerkes National Primate Research Center, Emory University, Atlanta, GA - - 2014
Clustered, regularly interspaced, short palindromic repeats-CRISPR associated (CRISPR-Cas) systems defend bacteria against foreign nucleic acids, such as during bacteriophage infection and transformation, processes which cause envelope stress. It is unclear if these machineries enhance membrane integrity to combat this stress. Here, we show that the Cas9-dependent CRISPR-Cas system of the ...
Wang Wenxiang W Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China; Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, - - 2014
Twenty-one-day-old female Wistar rats were treated daily with orally administered soy isoflavones (SIFs) at concentrations of 50, 100, or 200mg/kg body weight from weaning until sexual maturity (3mo.), and ovarian follicle development was evaluated. At the end of the treatment period, the ultrastructure of the ovarian granulosa cells was examined ...
Adema C M CM Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: - - 2014
Gastropod immunology is informed importantly by the study of the frequent encounters snails endure with digeneans (digenetic trematodes). One of the hallmarks of gastropod-digenean associations is their specificity: any particular digenean parasite species is transmitted by a limited subset of snail taxa. We discuss the nature of this specificity, including ...
Li Jie J Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, P. R. China; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, P. R. - - 2014
Luteolin has been reported to exert anti-fibrogenic effects in CCl4 induced hepatic fibrosis in mice. However, limited information is available on the cellular and molecular events responsible for this effect. The current study focused on the action of luteolin on HSCs and the relevant signaling molecules and pathways as well ...
Gangoda L L Department of Biochemistry, La Trobe Institute of Molecular Science, La Trobe University, Melbourne, Victoria, - - 2014
Loss of function mutations in the Prkar1a gene are the cause of most cases of Carney complex disorder. Defects in Prkar1a are thought to cause hyper-activation of PKA signalling, which drives neoplastic transformation, and Prkar1a is therefore considered to be a tumour suppressor. Here we show that loss of Prkar1a ...
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