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Results 51 - 100 of 1084
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Chun Katie - - 2013
[This corrects the article on p. e71575 in vol. 8.].
Li Jianhui - - 2013
[This corrects the article on p. e70331 in vol. 8.].
Maslanik Thomas - - 2013
[This corrects the article on p. e50636 in vol. 7.].
Sakharwade Sanica C - - 2013
[This corrects the article on p. e76583 in vol. 8.].
Cruz-Córdova Ariadnna - - 2013
[This corrects the article on p. e52091 in vol. 7.].
Hu Fanlei - - 2013
[This corrects the article on p. e72650 in vol. 8.].
Huang Jingfei - - 2013
[This corrects the article on p. e58499 in vol. 8.].
Tarosso Leandro F - - 2013
[This corrects the article on p. e11436 in vol. 5.].
Nishino Mari - - 2013
[This corrects the article DOI: 10.7554/eLife.00712.].
Busacca Sara - - 2013
[This corrects the article on p. e65489 in vol. 8.].
Lang Kuhs Krystle A - - 2013
[This corrects the article on p. e52165 in vol. 7.].
Singer Kanakadurga - - 2013
[This corrects the article on p. e57929 in vol. 8.].
Gao Anqi - - 2013
[This corrects the article DOI: 10.7717/peerj.51.].
Zhu Jianhua - - 2013
[This corrects the article on p. e46551 in vol. 7.].
Müller Silke - - 2013
[This corrects the article on p. e73439 in vol. 8.].
Malmstrøm Martin - - 2013
[This corrects the article on p. e74004 in vol. 8.].
Sarkar Roni - - 2013
[This corrects the article on p. e59073 in vol. 8.].
Onomoto Koji - - 2013
[This corrects the article on p. e43031 in vol. 7.].
Overbeek Saskia A - - 2013
[This corrects the article on p. e55612 in vol. 8.].
López-Acosta José Francisco - - 2013
[This corrects the article on p. e52862 in vol. 8.].
Amini-Vaughan Zhaleh J ZJ Department of Microbial and Molecular Pathogenesis, Texas A&M College of Medicine, Clinical Science and Translational Research Institute, Texas A&M Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, - - 2012
The eosinophil is a multifunctional granulocyte best known for providing host defense against parasites. Paradoxically, eosinophils are also implicated in the pathogenesis of allergic inflammation, asthma, and hypereosinophilic syndromes. Emerging evidence also supports the potential for harnessing the cytotoxic power of eosinophils and redirecting it to kill solid tumors. Central ...
Corvaisier Murielle - - 2012
[This corrects the article on p. e1001395 in vol. 10.].
Lau Ken S - - 2012
[This corrects the article on p. e1001393 in vol. 10.].
Nadda Neeti - - 2012
This study explored the role of pro- and anti-inflammatory cytokines in dimethyl benz(a)anthracene (DMBA)-induced lung cancer and its subsequent correction with a COX-2 inhibitory NSAID, etoricoxib. A single dose of DMBA (20 mg/kg body weight) in 0.9 % NaCl administered intratracheally was used to induce tumors in the rat lungs in 20 weeks. ...
Mejia Robin - - 2012
[This corrects the article on p. e1001359 in vol. 10.].
Nyström Sofia N - - 2012
Objective: AA amyloidosis is a complication to longstanding inflammatory diseases, but reduction of amyloid mass has been reported as the inflammation ceases. Not much is known about the endogenous factors that contribute to this amyloid resolution. Herein, we describe the dynamics of amyloid degradation and resolution in experimental murine AA-amyloidosis. ...
Kleemann Jochen - - 2012
[This corrects the article on p. e1002643 in vol. 8.].
Hohlfeld Reinhard - - 2012
β-Amyloid can modulate the immune response in a mouse model of multiple sclerosis (Grant et al., this issue).
Mejia Robin - - 2012
[This corrects the article on p. e1001359 in vol. 10.].
Leivo-Korpela Sirpa - - 2012
OBJECTIVES: Asbestos-exposure causes an inflammatory response driven by alveolar macrophages that can lead to pulmonary fibrosis. In addition to classical inflammatory cytokines, macrophages produce adipokines which regulate the inflammatory response. We studied if adipokines are related to the degree of parenchymal fibrosis, impaired lung function and inflammation in asbestos-exposed subjects. ...
Urbankowski Tomasz - - 2012
 Sarcoidosis is a multiorgan granulomatous disease of unknown etiology. The predominance of Th1‑related cytokines is observed in the bronchoalveolar fluid (BALF) in pulmonary sarcoidosis. Recently, Th17 cells have been postulated to be involved in the pathogenesis of sarcoidosis. Sarcoidosis is more prevalent in nonsmokers than in smokers. The exact effect of ...
Tajiri Kazuko - - 2012
Myocarditis and subsequent dilated cardiomyopathy are major causes of heart failure in young adults. Myocarditis in humans is highly heterogeneous in etiology. Recent studies have indicated that a subgroup of myocarditis patients may benefit from immune-targeted therapies, because autoimmunity plays an important role in myocarditis as well as contributing to ...
Skuk Daniel - - 2012
To detect the mechanisms of death in allogeneic myofibers rejected by the immune system, myoblasts were allotransplanted in muscles of macaques immunosuppressed with tacrolimus. Immunosuppression was stopped 1month later to induce a massive rejection of allogeneic myofibers. Grafted sites were biopsied at 2-week intervals and analyzed by histology. The loss ...
Peghini Bethânea Crema - - 2012
Several studies have suggested that patients with cervical intraepithelial and invasive neoplasia have reduced levels of Th1 cytokines, and increased levels of Th2 cytokines. Thus, the aim of this study was to delineate the immunological profile associated with lesion progression. Biopsies were obtained from 28 patients with low grade cervical ...
Nindl Veronika - - 2012
Myocarditis is a potentially lethal inflammatory heart disease of children and young adults that frequently leads to dilated cardiomyopathy (DCM). Since diagnostic procedures and efficient therapies are lacking, it is important to characterize the critical immune effector pathways underlying the initial cardiac inflammation and the transition from myocarditis to DCM. ...
Corsten Maarten F - - 2012
Viral myocarditis is an important cause of heart failure for which no specific treatments are available. Direct viral injury to cardiac cells provokes an inflammatory response that significantly contributes to cardiac damage and ensuing morbidity. Despite the central pathogenic role of autoimmune injury, broad inhibition of the inflammatory response does ...
Corsten Maarten F - - 2012
Rationale:Viral myocarditis results from an adverse immune response to cardiotropic viruses, which causes irreversible myocyte destruction and heart failure in previously healthy people. The involvement of microRNAs and their usefulness as therapeutic targets in this process are unknown.Objective:To identify microRNAs involved in viral myocarditis pathogenesis and susceptibility.Methods and Results:Cardiac microRNAs ...
Chan P T - - 2012
Pauci-immune necrotizing glomerulonephritis is a form of a rapidly progressive glomerulonephritis that is associated with the anti-neutrophil cytoplasmic antibodies (ANCA). ANCA-associated pauci-immune glomerulonephritis may be secondary to rheumatic diseases. We report on a patient with limited cutaneous systemic sclerosis who presented with subacute onset of nephritic syndrome and renal insufficiency. ...
Hosoki Koa - - 2012
Colonization by SA is associated with exacerbation of AD. Eosinophilic inflammation is a cardinal pathological feature of AD, but little is known about possible direct interaction between SA and eosinophils. PAFR appears to be involved in phagocytosis of Gram-positive bacteria by leukocytes. The objective of this study was to investigate ...
Silva Pedro Henrique Ramos Quintino da - - 2012
To investigate the significance of cellular immune markers, as well as that of collagen and elastic components of the extracellular matrix, within granulomatous structures in biopsies of patients with pulmonary or extrapulmonary sarcoidosis. We carried out qualitative and quantitative evaluations of inflammatory cells, collagen fibers, and elastic fibers in granulomatous ...
De Vico G - - 2012
Over the last few years, there has been a large increase in studying the biology and pathology of molluscs, predominantly in addressing the molecular patterns involved in their immune-mediated and inflammatory responses. Conversely, the literature-based diagnostic criteria concerning the morphology of the above phenomena still involves pathogenetic confusion and conflicting ...
Gu Xiaoyan - - 2012
Astragaloside IV (AS-IV) has been noted for its reduction of eosinophilic airway inflammation in a murine model of chronic asthma. To gain a better understanding of the mechanisms involved in this anti-inflammatory phenomenon, the effect of AS-IV on human blood eosinophils was studied in vitro. Eosinophils were isolated from the ...
Fairweather Delisa - - 2012
PURPOSE OF REVIEW: To present recent findings on the pathogenesis of coxsackievirus B3 (CVB3) myocarditis based on animal models, with a focus on the role of T helper (Th) immune responses in disease progression. RECENT FINDINGS: Acute CVB3 myocarditis is known to be increased by Th1 immune responses, but recent ...
Newman Kira L KL Emory University School of Medicine, Atlanta, Georgia, - - 2012
Sarcoidosis, the multiorgan granulomatous disease of unknown cause, remains mysterious. Several important investigations in the past 2 years add to the accumulating evidence for both occupational and environmental causes of granulomatous inflammation. This review considers the most recent studies that contribute to the hypothesis that sarcoidosis occurs when individuals are ...
Cohen Taylor Sitarik - - 2012
Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that regulates the transport of ions and the movement of water across the epithelial barrier. Mutations in CFTR, which form the basis for the clinical manifestations of cystic fibrosis, affect the epithelial innate immune function in the lung, resulting in ...
Driss Virginie - - 2012
Eosinophils have recently been shown to participate in innate immune responses against mycobacteria. We have investigated whether Mycobacterium bovis BCG regulate the human eosinophil immune response. A negative correlation between mycobacteria internalization and eosinophil activation was observed. In addition, mannose-capped lipoarabinomannan from M. bovis BCG (ManLAM) failed to induce a ...
Hsu Lewis L LL University of Illinois, - - 2012
Hydroxyurea treatment of sickle cell mice improved their survival from pneumococcal pneumonia, counteracting the abnormally elevated inflammatory response and reducing invasion of bacteria into the bloodstream, through down regulation of E-selectin.
Persad Rabindranath - - 2012
ABSTRACT: Eosinophilic Esophagitis (EoE) is a clinicopathologic diagnosis characterized by inflammation and infiltration of eosinophils at the esophageal mucosa. The underlying etiology of EoE remains elusive. Inflammatory diseases, such as asthma, are associated with structural remodeling of the airways, which includes angiogenesis. We compared the angiogenic profile of the esophageal ...
Hackett Tillie-Louise - - 2012
We currently understand little about the mechanisms that lead to airway remodeling in asthma. The origin of the mesenchymal cells that contribute to fibrosis of the airway is poorly understood. However, emerging evidence suggests that the airway epithelium could contribute to airway remodeling through the process of epithelial-mesenchymal transition (EMT) ...
Graber David J - - 2012
Limiting excessive production of inflammatory mediators is an effective therapeutic strategy for many diseases. It's also a promising remedy for neurodegenerative diseases and central nervous system (CNS) injuries. Glucocorticoids are valuable anti-inflammatory agents, but their use is constrained by adverse side-effects. Activators of NF-E2-related factor-2 (Nrf2) signaling represent an attractive ...
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