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Lang Bradley T BT Case Western Reserve University, Cleveland, OH 44121, - - 2014
Neuroinflammation is the foremost defense reaction of the nervous system to most if not all insults. Injuries to the central and peripheral nervous system (CNS and PNS) are followed by immediate activation of innate immune cells and infiltration of peripheral immune cells, amid waves of upregulation of numerous inflammatory mediators. ...
Sicard Mathieu M Université Montpellier 2, Institut des Sciences de l'Évolution, UMR CNRS 5554, Équipe Génomique de l'adaptation, Place Eugène Bataillon, F-34095 Montpellier cedex 05; Université de Poitiers, Laboratoire Écologie et Biologie des Interactions, UMR CNRS 7267, Équipe Écologie Évolution Symbiose, 5, rue Albert Turpin, F-86073 Poitiers cedex - - 2014
The Wolbachia are intracellular endosymbionts widely distributed among invertebrates. These primarily vertically transmitted α-proteobacteria have been intensively studied during the last decades due to their intriguing interactions with hosts, ranging from reproductive manipulations to mutualism. To optimize their vertical transmission from mother to offspring, the Wolbachia have developed fine-tuned strategies. ...
Rao Youliang - - 2014
High-mobility group box (HMGB) proteins, a family of chromatin-associated nuclear proteins, play amazingly multifaceted roles in the immune system of mammals. Thus far, little is known about the nucleocytoplasmic distribution of HMGBs in teleosts. The present study systematically investigated the dynamic localization of all six HMGB proteins in Ctenopharyngodon idella ...
Chuang Shu-Chun SC Department of Physiology, College of Medicine,Kaohsiung Medical University,No. 100, Shih-Chuan 1st Road, Kaohsiung - - 2014
SUMMARY Current development efforts of subunit vaccines against Toxoplasma gondii, the aetiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigens (SAGs) such as SAG2, due to their attachment roles in the process of host-cell invasion. In the present study, we aimed to produce poly(lactide-co-glycolide) (PLG) microparticles (MPs) ...
Han X X Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) and Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, - - 2014
IL-17 is one of the most potent and most actively investigated proinflammatory cytokines. In this study, we examined the effect of IL-17 on mesenchymal stem cells (MSCs) under the influence of inflammatory cytokines. Ironically, IL-17 dramatically enhanced the immunosuppressive effect of MSCs induced by IFNγ and TNFα, revealing a novel ...
Pereira Andrea Mendes - - 2014
Very few studies have been carried out so far aiming at modulating cellular immune responses in dogs. In this study, we evaluated the ability of recombinant canine IL-2 (rcaIL-2) and IL-12, in the form of a single-chain fusion protein (rsccaIL-12), to stimulate peripheral blood mononuclear cells (PBMC) of healthy mongrel ...
Gallo Vittorio V Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010, USA. Electronic address: - - 2014
Given the complexities of the mammalian CNS, its regeneration is viewed as the holy grail of regenerative medicine. Extraordinary efforts have been made to understand developmental neurogenesis, with the hopes of clinically applying this knowledge. CNS regeneration also involves glia, which comprises at least 50% of the cellular constituency of ...
Pajarinen Jukka J Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, - - 2014
Modulation of macrophage polarization is emerging as promising means to mitigate wear particle-induced inflammation and periprosthetic osteolysis. As a model for continuous local drug delivery, we used miniature osmotic pumps to deliver IL-4 in order to modulate macrophage polarization in vitro from nonactivated M0 and inflammatory M1 phenotypes towards a ...
Davies D Huw DH Division of Infectious Diseases, School of Medicine, University of California, Irvine, Irvine, CA 92697; Antigen Discovery, Inc., Irvine, CA 92618; and - - 2014
Vaccinia virus (VACV) is a useful model system for understanding the immune response to a complex pathogen. Proteome-wide Ab profiling studies reveal the humoral response to be strongly biased toward virion-associated Ags, and several membrane proteins induce Ab-mediated protection against VACV challenge in mice. Some studies have indicated that the ...
Tiantong Attapol A Department of Animal Science, National Chung Hsing University, Taichung, - - 2014
A problem for dairy cows following milk stasis is to cope with a high risk of intramammary infection and there is a need to initiate an extensive renewal of secretory modules in mammary glands so that milk production in next lactation may be optimized. We recently reported that ultrasonicated Enterococcus ...
Chen Zetao Z Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, Brisbane, Queensland 4059, Australia; Australia-China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, Brisbane, Queensland 4059, - - 2014
The osteoimmunomodulatory property of bone biomaterials is a vital property determining the in vivo fate of the implants. Endowing bone biomaterials with favorable osteoimmunomodulatory properties is of great importance in triggering desired immune response and thus supports the bone healing process. Magnesium (Mg) has been recognized as a revolutionary metal for ...
Guo Weixin W Guangdong Geriatrics Institute, Guangdong General Hospital, Guangdong Academy of Medical sciences No. 106, Zhongshan Road, Guangzhou 510100, - - 2014
The Stromal Cell-Derived Factor-1α/C-X-C Chemokine Receptor 4 (SDF-1/CXCR4) axis is involved in various aspects of tissue repair, regeneration and development. However, the role of SDF-1/CXCR4 in acute lung injury (ALI) remains largely unknown. The aim of the present investigation is to examine pathological changes in a rabbit model with ALI ...
Wang Hsiao-Chun HC School of Pharmacy and Center for Innovative Therapeutics Discovery, National Taiwan University, No. 33, LinSen South Road, Taipei 10051, - - 2014
Bioisosteric replacement of acylureido moiety in 6-acylureido-3-pyrrolylmethylidene-2-oxoindoline derivatives resulted in a series of malonamido derivatives with indolin-2-one scaffold (11-14). Further conformational restrictions of the malonamido moiety led to 2-oxo-1,2-dihydropyridine (21-25) or a 4-oxo-1,4-dihydropyridine derivatives (31-36). 4-Oxo-1,4-dihydropyridine derivatives were more potent Aurora B inhibitors than their 2-oxo-1,2-dihydropyridine counterparts and demonstrated cytotoxicities ...
Beloqui Ana A Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, 1200 Brussels, - - 2014
Nano-scaled particles have been found to preferentially accumulate in inflamed regions. Local delivery of anti-inflammatory drugs loaded in nanoparticles to the inflamed colonic site is of great interest for inflammatory bowel disease (IBD) treatment. Curcumin (CC) is an anti-inflammatory local agent, which presents poor ADME properties. Hence, we evaluated, both ...
Du Yun Y The Forth Hospital of Hebei Medical University, Hebei Province China-Japan Feriendship Center for Cancer Detection, - - 2014
While Bcl-2 protein is involved in the regulation of apoptosis, recent research showed that Beclin1, described as the essential autophagy effector and haploinsufficent tumour suppressor, was originally isolated as a Bcl-2 interacting protein. Beclin1 interacts with Bcl-2 through a BH3 domain; nevertheless, the function of the anti-apoptotic gene, Bcl-2, in ...
Herhaus Lina L MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, United - - 2014
The members of the transforming growth factor beta (TGFβ) family of cytokines, including bone morphogenetic proteins (BMP), play fundamental roles in development and tissue homeostasis. Hence, aberrant TGFβ/BMP signalling is associated with several human diseases such as fibrosis, bone and immune disorders, cancer progression and metastasis. Consequently, targeting TGFβ signalling ...
Huang Mianbo M School of Biology and the Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, - - 2014
In chronic liver failure patients with sustained fibrosis, excessive accumulation of extracellular matrix (ECM) proteins substantially dampens the regenerative capacity of the hepatocytes, resulting in poor prognosis and high mortality. Currently, the mechanisms and the strategies of inducing endogenous cellular sources such as hepatic progenitor cells (HPCs) to regenerate hepatocytes ...
Aurora Arin B AB Department of Molecular Biology and Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, - - 2014
The immune system, best known as the first line of defense against invading pathogens, is integral to tissue development, homeostasis, and wound repair. In recent years, there has been a growing appreciation that cellular and humoral components of the immune system also contribute to regeneration of damaged tissues, including limbs, ...
Huang Li L Department of Nephrology, The Third Affiliated Hospital of Guangzhou Medical University , Guangzhou , China - - 2014
Abstract Podocytes are highly differentiated epithelial cells that form interdigitating foot processes with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. Proteinuria is the most common clinical manifestation of glomerular diseases. Losartan is the traditional renin-angiotensin system (RAS). However; the precise mechanisms underlying the beneficial effects of Losartan on podocytes ...
Dong Jie J Key Laboratory of Diagnostic Medicine designated by the Ministry of Education Chongqing Medical University, 400016, Chongqing, - - 2014
Interaction between pneumococcal virulence factors and innate immune receptors triggers host responses via specific signaling pathways after infection. By generating deficient mutant, we showed here that, compared with wild-type parent strain, glycosyl hydrolase 25 relating to invasion protein mutant strain was impaired in rapid dissemination into vessel and caused less ...
Wolf Matthew T MT University of Pittsburgh, Bioengineering, Pittsburgh, Pennsylvania, United States, University of Pittsburgh, McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania, United States ; - - 2014
The host response to both synthetic and biologically-derived biomaterials is a temporally regulated, complex process that involves multiple interacting cell types. This complexity has classically limited the efficacy of in vitro assays for predicting the in vivo outcome, necessitating the use of costly animal models for biomaterials development. The present ...
Jiu-Rong Li L Department of Respiratory Diseases,PUMC Hospital,CAMS and PUMC,Beijing - - 2014
Objective To determine the changes in the airway inflammation-related cytokine/chemokine profiles after exposure to cigarette smoke(CS)and smoking cessation(SC). Methods A total of 18 male C57BL/6 mice were equally divided into three groups:CS group,SC group,and normal control group. The airway resistance,lung morphology,and collagen deposition around airways were determined. HE staining and ...
Aredia Francesca F Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, 27100 Pavia, - - 2014
Poly(ADP-ribosylation) results from the conversion of NAD(+) into ADP-ribose and the following addition of ADP-ribose units to form polymers, further bound to acceptor proteins; once post-translationally ADP-ribosylated, proteins could change their function in basic processes. Poly(ADP-ribosylation) is activated under critical situations represented by DNA damage and cellular stress, and modulated ...
Puri Sumant S Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York, 14214 - - 2014
Histatins are salivary cationic peptides that provide the first line of defense against oral candidiasis caused by Candida albicans. This review presents a critical evaluation of our knowledge of the candidacidal mechanism of Histatin 5 (Hst 5). Hst 5 is the most potent among all Histatin family members with regards ...
Hasegawa Urara - - 2014
Hydrogen sulfide (H2S) is a gaseous signaling molecule that has several important biological functions in the human body. Due to the difficulties of handling H2S gas, small organic compounds that release H2S under physiological conditions have been developed. The observed bioactivities of these H2S donors have generally been directly correlated ...
Patel Brijeshkumar B Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter Drive, Amarillo, Texas, 79106, - - 2014
Cysteinyl leukotrienes (CysLTs) propagate inflammatory reactions that result from allergen exposure in asthma. Montelukast, a CysLT type-1 receptor antagonist, disrupts mediator-receptor interactions and minimizes inflammatory response. In this study, we have evaluated anti-asthmatic efficacy of inhalable montelukast-loaded large porous particulate formulations in ovalbumin-induced rat airway inflammation model that mimics asthma. ...
Baruah Kartik K Laboratory of Aquaculture & Artemia Reference Center, Department of Animal Production, Faculty of Bioscience Engineering, Ghent University, Rozier 44, Gent 9000, Belgium. Electronic address: - - 2014
The cytoprotective role of heat shock protein (Hsp70) described in a variety of animal disease models, including vibriosis in farmed aquatic animals, suggests that new protective strategies relying upon the use of compounds that selectively turn on Hsp genes could be developed. The product Tex-OE(®) (hereafter referred to as Hspi), ...
Chan Kannie W Y KW Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, USA; Center of Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Baltimore, MD 21205, - - 2014
By means of physical isolation of cells inside semi-permeable hydrogels, encapsulation has been widely used to immunoprotect transplanted cells. While spherical alginate microcapsules are now being used clinically, there still is little known about the patient's immune system response unless biopsies are obtained. We investigated the use of Magnetization Transfer ...
Tarr Andrew J AJ Division of Biosciences, The Ohio State University, 305 W. 12[th] Ave Columbus, OH 43210, USA; Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, 460 Medical Center Dr., Columbus, OH 43210, USA. Electronic address: - - 2014
We found recently that controlled progressive challenge with subthreshold levels of E.coli can confer progressively stronger resistance to future reinfection-induced sickness behavior to the host. We have termed this type of inflammation "euflammation". In this study, we further characterized the kinetic changes in the behavior, immunological, and neuroendocrine aspects of ...
Tan Cheau Yih - - 2014
Mesenchymal stem cell-conditioned medium (MSC-CM) has been shown to have protective effects against various cellular injury models. This mechanism of protection, however, has yet to be elucidated. Recently, exosomes have been identified as the active component in MSC-CM. The aim of this study is to investigate the effect of MSC-derived ...
Chi Xiaoke X Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario L8N 3Z5, - - 2014
Bcl-2 family proteins are central regulators of apoptosis. Various family members are located in the cytoplasm, endoplasmic reticulum, and mitochondrial outer membrane in healthy cells. However during apoptosis most of the interactions between family members that determine the fate of the cell occur at the membranes of intracellular organelles. It ...
van der Oost John J Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The - - 2014
Bacteria and archaea have evolved sophisticated adaptive immune systems, known as CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) systems, which target and inactivate invading viruses and plasmids. Immunity is acquired by integrating short fragments of foreign DNA into CRISPR loci, and following transcription and processing of these loci, the ...
Zhu Rong R State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, - - 2014
A ranavirus-induced thymus cDNA library was constructed from Chinese giant salamander, the largest extant amphibian species. Among the 137 putative immune-related genes derived from this library, these molecules received particular focus: immunoglobulin heavy chains (IgM, IgD, and IgY), IFN-inducible protein 6 (IFI6), and T cell receptor beta chain (TCRβ). Several ...
Zhao X-M XM Embryo Biotechnology and Reproduction Laboratory, Institute of Animal Science (IAS), Chinese Academy of Agricultural Sciences (CAAS), Beijing, - - 2014
This study utilized three staining assays (Annexin V, mitochondrial membrane potential (JC-1) and TUNEL) for flow cytometric analysis of apoptosis in sex-sorted sperm from four different bulls (A, B, C and D). Correlations between sperm quality and IVF efficiency were then assessed to determine which assay provided the best prediction ...
Brulois Kevin K Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Harlyne J. Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, California 90033, - - 2014
The downregulation of immune synapse components such as MHC-I and ICAM-1 is a common viral immune evasion strategy that protects infected cells from targeted elimination by cytolytic effector functions of the immune system. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes two membrane-bound ubiquitin E3 ligases called K3 and K5, which share the ...
Liu Yuxiu Y Laboratory Animal Research Center, Institute of Medical Science, The University of - - 2014
Interleukin 18 (IL-18) plays an important role in the T-helper-cell type 1 immune response against intracellular parasites, bacteria, and viral infections. It has been widely used as an adjuvant for vaccines and as an anticancer agent. However, IL-18 protein lacks a typical signal sequence and requires cleavage into its mature ...
Rebouças Juliana De S JD Adjuvant Unit, Department of Pharmacy and Pharmaceutical Technology, and Department of Microbiology, University of Navarra, 31008, Pamplona, - - 2014
In the last decade, peanut allergy is increasing substantially. Significant differences in the prevalence among different countries are attributed to the type of thermal processing. In spite of the high prevalence and the severe reaction induced by peanut, there is no immunotherapy available. The aim of this work was to ...
Pedrazza Leonardo L Laboratório de Pesquisa em Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6681, prédio 12, bloco C, sala 221, Porto Alegre, Rio Grande do Sul, CEP 90619-900, - - 2014
Mesenchymal stem cells (MSCs) are potent modulators of immune responses. Sepsis is the association of a systemic inflammatory response with an infection. The aim of this study was to test the ability of MSCs derived from adipose tissue, which have immunomodulatory effects, and to inhibit the septic process in an ...
Jain Sanyog - - 2014
The present study embarks on the feasibility of GM-bilosomes as a rationally designed vehicle for oral mucosal immunization. Bilosomes containing BSA as a model antigen were found to have vesicle size of 157 +/- 3 nm, PDI of 0.287 +/- 0.045, zeta potential of -21.8 +/- 2.01 mV and entrapment ...
Khanlari Zahra Z Department of Medical Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR - - 2014
Hepatitis C virus (HCV) is able to down-regulate innate immune response. It is important to know the immune pathways that this virus interacts with. HCV non-structural protein 3 (NS3) plays an important role in this viral feature. HCV NS3 protein could affect the expression of antiviral protein such as viperin, ...
Godinho-Silva Cristina C Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, - - 2014
Persistent infections are subject to constant surveillance by CD8+ cytotoxic T cells (CTL). Their control should therefore depend on MHC class I-restricted epitope presentation. Many epitopes are described for γ-herpesviruses and form a basis for prospective immunotherapies and vaccines. However the quantitative requirements of in vivo immune control for epitope ...
Wang Rui R MOE Key Laboratory of Aquatic Product Safety / State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, People's Republic of - - 2014
Infectious spleen and kidney necrosis virus (ISKNV) belongs to the genus Megalocytivirus in the family Iridoviridae. This virus is the etiological agent of a serious and pandemic disease in fish. Cells infected with ISKNV undergo apoptosis. In this study, the ISKNV ORF005L gene was characterized and functionally investigated. Bioinformatics analysis ...
Abo Masahiro - - 2014
Hydrogen peroxide (H2O2), a member of reactive oxygen species (ROS), plays diverse physiological roles including host defense and cellular signal transduction. During ingestion of invading microorganisms, professional phagocytes such as macrophages release H2O2 specifically into the phagosome to direct toxic ROS toward engulfed microbes. Although H2O2 is considered to exert ...
Natasha G Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, London, United Kingdom; UCL Medical School, University College London, London, United - - 2014
Exosomes are small biological membrane vesicles that measure 30 to 100 nm in diameter. They are involved in a wide array of biological activities, such as cell-cell communication, signal transduction, transport of genetic materials, and modulation of immune response. Evidence indicates that they can be used as not only therapeutic ...
Price Dwan B DB Centre for Cellular and Molecular Biology (CCMB), School of Life and Environmental Sciences, Deakin University, Burwood, Victoria, - - 2014
Background/Aims: Allergen absorption by epithelia may play an important role in downstream immune responses. Transport mechanisms that can bypass Peyer's patches include transcellular and paracellular transport. The capacity of an allergen to cross via these means can modulate downstream processing of the allergen by the immune system. The aim of ...
Wolf Matthew T MT Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, - - 2014
The host response to implanted biomaterials is a highly regulated process that influences device functionality and clinical outcome. Non-degradable biomaterials, such as knitted polypropylene mesh, frequently elicit a chronic foreign body reaction with resultant fibrosis. Previous studies have shown that an extracellular matrix (ECM) hydrogel coating of polypropylene mesh reduces ...
Kim Jaeyun - - 2014
The in vivo enrichment of dendritic cells (DCs) in implanted macroporous scaffolds is an emerging strategy to modulate the adaptive immune system. The pore architecture is potentially one of the key factors in controlling enrichment of DCs. However, there have been few studies examining the effects of scaffold pore structure ...
Zhang Qing Q MOE Key Laboratory of Plant Cell Engineering and Germplasm Innovation / Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, Jinan, Shandong, 250100, - - 2014
Calnexin (Cnx) is an endoplasmic reticulum membrane-bound lectin chaperone that comprises a dedicated maturation system with another lectin chaperone calreticulin (Crt). This maturation system is known as the Cnx/Crt cycle. The main functions of Cnx are Ca(2+) storage, glycoprotein folding, and quality control of synthesis. Recent studies have shown that ...
Kansal S S Pharmaceutics Division, CSIR-Central Drug Research Institute, BS-10/1 sector-10 Jankipuram Extension, Lucknow 226031, - - 2014
Aim of present study was to evaluate the immunomodulatory and chemotherapeutic potential of alginate (SA) coated nanocapsule (NCs) loaded with doxorubicin (SA-NCs-DOX) for synergistic action against visceral leishmaniasis (VL) in comparison with nano-emulsion bearing doxorubicin (NE-DOX). Low energy emulsification method was utilized to prepare NE-DOX. Stepwise addition of protamine sulphate ...
Grotenhuis N N Department of Otorhinolaryngology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands; Department of General Surgery, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The - - 2014
Macrophages play an important role in the reaction to biomaterials, which sometimes have to be used in a surgical field at risk of contamination. The macrophage phenotype in reaction to biomaterials in an inflammatory environment was evaluated in both an in vivo and in vitro setting. In the in vivo setting, polypropylene (PP) ...
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