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Mora-Solano Carolina C University of Chicago, Department of - - 2014
Adaptive immune responses, characterized by T cells and B cells engaging and responding to specific antigens, can be raised by biomaterials containing proteins, peptides, and other biomolecules. How does one avoid, control, or exploit such responses? This review will discuss major properties and processes that influence biomaterials-directed adaptive immunity, including ...
Sawant Deepali V DV Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, - - 2014
Regulatory T cells (Tregs) prevail as a specialized cell lineage that has a central role in the dominant control of immunological tolerance and maintenance of immune homeostasis. Thymus-derived Tregs (tTregs) and their peripherally induced counterparts (pTregs) are imprinted with unique Forkhead box protein 3 (Foxp3)-dependent and independent transcriptional and epigenetic ...
Isik Gözde G Laboratory of Experimental Virology, Department of Medical Microbiology Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The - - 2014
Cytokines are often used as adjuvants to increase the immunogenicity of vaccines because they can improve the immune response and/or direct it into a desired direction. As an alternative to codelivering Ags and cytokines separately, they can be fused into a composite protein, with the advantage that both moieties act ...
Yan Hao - - 2014
The epithelial barrier dysfunction plays a critical role in the pathogenesis of a broad array of immune diseases. Alix protein is involved in the endolysosome system. This study aims to elucidate the role of Alix in the maintenance of epithelial barrier function. The results showed that Alix was detected in ...
Shisler Joanna L JL Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, - - 2014
FLICE-inhibitory proteins (FLIPs) are a family of viral (poxvirus and herpesvirus) and cellular proteins. The hallmark of this family is the presence of tandem death-effector domains (DED). Despite this shared motif, each protein possesses different abilities to modulate apoptosis, NF-κB and IRF3. These similarities and differences are discussed and highlighted ...
Fearing Bailey V BV Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, NC - - 2014
Macrophage response to biomaterials is emerging as a major focus in tissue repair and wound healing. Macrophages are able to differentiate to two distinct states eliciting divergent effects. The M1 phenotype is considered pro-inflammatory and up-regulates activity related to tissue destruction, while the M2 phenotype is considered anti-inflammatory and supports ...
Lennon Gráinne G School of Medicine and Medical Sciences; University College Dublin; Dublin, Ireland; Centre for Colorectal Disease; St Vincent's University Hospital; Elm Park, - - 2014
The colonic mucus gel layer (MGL) is a critical component of the innate immune system acting as a physical barrier to microbes, luminal insults, and toxins. Mucins are the major component of the MGL. Selected microbes have the potential to interact with, bind to, and metabolize mucins. The tolerance of ...
Kang Bin - - 2014
Apoptosis is a biological process that plays important roles in embryogenesis, aging and various diseases. During the process of apoptosis cells undergo a series of morphological and molecular events such as blebbing, cell shrinkage, proteolysis, and nuclear DNA fragmentation. Investigating these events on a molecular level is crucial for gaining ...
Choi Gil-Soon GS Departments of Internal Medicine, Kosin University College of Medicine, Republic of - - 2014
Titanium dioxide (TiO2) is increasingly widely used in industrial, commercial and home products. TiO2 aggravates respiratory symptoms by induction of pulmonary inflammation although the mechanisms have not been well investigated. We aimed to investigate lung inflammation in rabbits after intratracheal instillation of P25 TiO2. One ml of 10, 50 and ...
Santoni de Sio Francesca F San Raffaele Scientific Institute; Telethon Institute for Gene Therapy; Milan, - - 2014
The ability of adaptive immune system to protect higher vertebrates from pathogens resides in the ability of B and T cells to express different antigen specific receptors and to respond to different threats by activating distinct differentiation/activation pathways. In the past 10 years, the major role of epigenetics in controlling ...
Gurung Ratna B RB Faculty of Veterinary Science, University of Sydney, Camden, NSW, - - 2014
Johne's disease in ruminants is a chronic infection of the intestines caused by Mycobacterium avium subspecies paratuberculosis. An important strategy to control disease is the early detection and a potentially efficient method for early detection by measuring cell mediated immune responses developed by the host in response to exposure or ...
Valenti Maria Teresa MT Department of Medicine, Clinic of Internal Medicine, section D, University of Verona, Piazzale Scuro, 10, 37134 Verona, Italy. - - 2014
Background/Aim: Osteosarcoma originates from mesenchymal stem cells with impaired bone differentiation. In the present study we investigated the effect of ascorbic acid (AsA) on osteogenic differentiation and apoptosis of the MG-63 osteosarcoma cell line. We evaluated the expression of runt-related transcription factor-2 (RUNX2) and secreted phosphoprotein 1 (SPP1) genes by ...
Warren Kristi J - - 2014
Lymph nodes (LNs) are integral sites for the generation of immune tolerance, migration of CD4+ T cells, and induction of Tregs. Despite the importance of LNs in regulation of inflammatory responses, the LN-specific factors that regulate T cell migration and the precise LN structural domains in which differentiation occurs remain ...
Chmilewsky Fanny F Aix Marseille Université, Centre National de la Recherche Scientifique, Institut des Sciences du Movement Unité Mixte de Recherche 7287, Marseille, - - 2014
Many aspects of dentin pulp tissue regeneration have been investigated, and it has been shown that dentin pulp has a high regeneration capacity. This seems to be because of the presence of progenitor cells and inductive regeneration signals from different origins. These signals can be liberated after the acidic dissolution ...
Zirngibl Matthias M Department of Internal Medicine 3, University of Erlangen-Nürnberg, Germany; Department for General Pediatrics, Haematology and Oncology, University Children's Hospital Tübingen, - - 2014
Most cases of systemic lupus erythematosus (SLE) are characterized by an impaired clearance of apoptotic cells in various tissues. Not cleared apoptotic waste is considered an immunogen driving the autoimmune response in patients with SLE. During the execution of apoptosis, membrane blebs are formed and filled with cellular components. Here, ...
Li Bing B Department of Ophthalmology, First Hospital of Liaoning Medical College, Jinzhou, Liaoning 121001, P.R. - - 2014
The aim of the present study was to examine the effect of exogenous IL-10 transfected rat dendritic cells (DCs) in corneal allografts. Rat lymphocyte separation medium and a cytokine induction method was used to extract and culture precursor cells of rat bone marrow-derived dendritic cells. A corneal transplant model was ...
Ivanov Pavel P Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, - - 2014
Translational control of gene expression contributes to various aspects of immune function [1]. Recent results by Brubaker et al. [2] show how alternative translation initiation produces distinct isoforms of Mitochondrial Antiviral Signaling (MAVS), an adaptor protein associated with RIG-I and MDA5 that possess unique immunomodulatory properties.
Jawale Chetan V CV College of Veterinary Medicine, Chonbuk National University, Jeonju, 561-756, Republic of - - 2014
The Escherichia coli heat-labile enterotoxin B subunit (LTB) is a potent vaccine adjuvant. Salmonella Enteritidis ghosts carrying LTB (S. Enteritidis-LTB ghosts) were genetically constructed using a novel plasmid, pJHL187-LTB, designed for the coexpression of the LTB and E lysis proteins. Salmonella Enteritidis-LTB ghosts were characterized using scanning electron microscopy to ...
Dinga Jerome Nyhalah JN Biotechnology Unit, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon. Electronic address: - - 2014
Malaria remains a public health hazard in tropical countries as a consequence of the rise and spread of drug and insecticide resistances; hence the need for a vaccine with widespread application. Protective immunity to malaria is known to be mediated by both antibody and cellular immune responses, though characterization of ...
Katsaris Matthew P MP 4(th) Department of Internal Medicine, University of Athens, Medical School, 12462 Athens, Greece; 2(nd) Department of Urology, University of Athens, Medical School, 12462 Athens, Greece. Electronic address: - - 2014
To investigate the efficacy of recombinant human interferon gamma (rhIFNγ) in experimental pyelonephritis by Escherichia coli METHODS: Pyelonephritis was induced by intrapelvic inoculation of bacteria after ureteral ligation in 38 rabbits assigned in three groups: group A (n= 16) controls (n=12); group B (n= 14) treated with intravenous rhIFNγ; and ...
Zhang Ying Y College of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206, People's Republic of - - 2014
Immunostimulating complexes (ISCOMs), a kind of novel antigen presenting system, could enhance immune protection by antigen presentation. AbISCO®-300 comprising purified saponin, cholesterol and phosphatidyl choline is an effective ISCOM adjuvant. To evaluate the immune protection of recombinant 3-1E protein against Eimeria acervulina infection, chickens were immunized with recombinant 3-1E protein ...
Ballotta Virginia V Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands. Electronic address: - - 2014
Implanted synthetic substrates for the regeneration of cardiovascular tissues are exposed to mechanical forces that induce local deformation. Circulating inflammatory cells, actively participating in the healing process, will be subjected to strain once recruited. We investigated the effect of deformation on human peripheral blood mononuclear cells (hPBMCs) adherent onto a ...
Lelio Ilaria Di ID Dipartimento di Agraria, Università degli Studi di Napoli "Federico II", via Università 100, 80055 Portici (Napoli), - - 2014
Insect immune defences rely on cellular and humoral responses targeting both microbial pathogens and metazoan parasites. Accumulating evidence indicates functional cross-talk between these two branches of insect immunity, but the underlying molecular mechanisms are still largely unknown. We recently described, in the tobacco budworm Heliothis virescens, the presence of amyloid ...
Chang Hong Tao - - 2014
A recombinant replication-defective adenovirus expressing the major epitopes of Porcine Circovirus-2 (PCV-2) capsid protein (rAd/Cap/518) was previously constructed, and shown to induce mucosal immunity in mice via intranasal immunization. The immune responses induced by intranasal immunization with the combination of rAd/Cap/518 and CpG ODN were evaluated in mice in this ...
Jessen Danielle L DL Department of Basic Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, - - 2014
Pathogens are recognized by hosts using various receptors including the TLR- and NLR-families. Ligands, for these varied receptors including bacterial products, are identified by the immune system resulting in development of innate immune responses. Only a couple of components from type III secretion systems are known to be recognized by ...
Ferreira Jean Carlos Barbosa JC Department of Oral Medicine (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, - - 2014
The aim of this study was to investigate the neoplastic potential of the PA of minor oral salivary glands measured by apoptosis (Bcl-2, Bax and p53), mucosecretory activity (MUC1), and cellular proliferation (Ki-67). Thirty-one cases of PA of the oral cavity and four controls (C) taken from normal oral minor ...
Fadel Tarek R TR Department of Chemical Engineering, Yale University, PO Box 208284, New Haven, CT, USA. Electronic address: - - 2014
Carbon nanotubes (CNTs) have the potential to overcome significant challenges related to vaccine development and immunotherapy. Central to these applications is an improved understanding of CNT interactions with the immune system. Unique properties such as high aspect ratio, flexible surface chemistry, and control over structure and morphology may allow for ...
McCarthy Derrick P DP Department of Microbiology-Immunology and Interdepartmental Immunobiology Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, - - 2014
The growing prevalence of nanotechnology in the fields of biology, medicine, and the pharmaceutical industry is confounded by the relatively small amount of data on the impact of these materials on the immune system. In addition to concerns surrounding the potential toxicity of nanoparticle (NP)-based delivery systems, there is also ...
Stenger Rachel M RM Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment, Bilthoven, The - - 2014
Knowledge of naturally processed Bordetella pertussis (B. pertussis) specific T cell epitopes may help to better understand the basis of cell-mediated immune mechanisms to control this re-emerging pathogen. Here we for the first time elucidate dominant MHC class II-presented B. pertussis CD4(+) T cell epitopes, expressed on human monocyte-derived dendritic ...
Harde Harshad H Center for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research, SAS Nagar, Punjab, 160062, - - 2014
Aim: The aim of this study was to develop a novel platform technology, comprising of stable glucomannosylated chitosan nanoparticles, for oral immunization. Materials & methods: Chitosan nanoparticles were stabilized by tandem crosslinking using tripolyphosphate followed by glutaraldehyde. Process and formulation variables were optimized using a 'Box-Behnken' design. The in vitro ...
Garbin Ulisse U Medicina Interna D,, Medicine, verona, Italy, Medicina Interna D, Medicine, Verona, Italy ; - - 2014
Macrophage apoptosis is involved in atherosclerotic plaque development. The aim of this study was to evaluate the interrelationship between macrophage apoptosis and the endoplasmic reticulum (ER)-stress in the tissue around the necrotic core (TANC) and in the periphery (P) of the same carotid plaques derived from patients undergoing carotid endarterectomy. ...
Hermans David - - 2014
Campylobacter jejuni is the most common cause of bacterium-mediated diarrheal disease in humans worldwide. Poultry products are considered the most important source of C. jejuni infections in humans but to date no effective strategy exists to eradicate this zoonotic pathogen from poultry production. Here, the potential use of passive immunization ...
Segawa Ryosuke R Graduate School of Pharmaceutical Sciences, Tohoku University, - - 2014
Environmental chemicals, such as cigarette smoke and diesel exhaust, have been reported as risk factors that exacerbate allergic diseases. However, the exacerbation mechanisms induced by these chemicals are not yet fully understood. Thymic stromal lymphopoietin (TSLP) is produced mainly by epithelial cells and plays an important role as a master ...
Silvestre Bruna T BT Department of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, - - 2014
Bovine anaplasmosis is a disease caused by the intraerythrocytic rickettsia Anaplasma marginale. Surface proteins (MSPs) of A. marginale are important in the interaction of the pathogen with the host and constitute potential vaccine targets against this pathogen. Currently, there is no commercial inactivated vaccine against bovine anaplasmosis that can generate ...
Dixit Saurabh S Center for NanoBiotechnology Research (CNBR), Alabama State University, Montgomery, AL, - - 2014
PLA-PEG [poly (lactic acid)-poly (ethylene glycol)], a biodegradable copolymer, is underexploited for vaccine delivery although it exhibits enhanced biocompatibility and slow release immune-potentiating properties. We document here successful encapsulation of M278, a Chlamydia trachomatis MOMP (major outer membrane protein) peptide, within PLA-PEG nanoparticles by size (~73-100 nm), zeta potential (-16 ...
Liang Jun-Jun JJ Department of Cardiovascular Thoracic Surgery, Anqiu People's Hospital, Anqiu 262100, - - 2014
To establish rabbit model of restenosis after carotid endarterectomy surgery, and to study tissue inflammatory cytokines (TNF-α, IL-6) involved in restenosis. A total of 32 rabbits were randomly divided into two groups: model group and control group. The right common carotid artery in rabbits was damaged by carotid endar terectomy ...
Ilyinskii Petr O PO Selecta Biosciences, Watertown, MA 02472, USA. Electronic address: - - 2014
Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions in vivo, leading to potential adverse events and safety concerns. We have developed a synthetic vaccine particle (SVP) technology that enables co-encapsulation of ...
Roch Toralf T Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Kantstraße, Teltow, Germany Helmholtz Virtual Institute - Multifunctional Biomaterials for Medicine, Teltow and Berlin, - - 2014
With the worldwide increase of atherosclerosis, the need for new engineered patient specific implants such as stents or vascular grafts is still emerging. Recently, very smooth poly(ether imide) (PEI) films were, based on their excellent hemocompatibility and compatibility with endothelial cells, suggested as potential biomaterial for cardiovascular applications. In atherosclerosis, ...
Curley Gerard F - - 2014
Mesenchymal stem/stromal cells (MSCs) have become the focus of intense research effort over the past 10 years, in an effort to harness their regenerative and immune-modulating capacity for a variety of clinical conditions. In Acute Respiratory Distress Syndrome (ARDS), pre-clinical studies point towards a therapy that modulates multiple aspects of ...
Spiller Kara L KL Department of Biomedical Engineering, Columbia University, 622 West 168th Street, New York, NY 10032, USA; School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Chestnut St., Philadelphia, PA 19104, - - 2014
Angiogenesis is crucial for the success of most tissue engineering strategies. The natural inflammatory response is a major regulator of vascularization, through the activity of different types of macrophages and the cytokines they secrete. Macrophages exist on a spectrum of diverse phenotypes, from "classically activated" M1 to "alternatively activated" M2 ...
Branham-O'Connor Melissa M Medical University of South Carolina, United - - 2014
Activator of G protein Signaling 3 (AGS3, gene name G-protein signaling modulator, Gpsm1)(1), an accessory protein for G protein signaling, has functional roles in the kidney and CNS. Here we show that AGS3 is expressed in spleen, thymus and bone marrow-derived dendritic cells (BMDCs), and is upregulated upon leukocyte activation. ...
Castellano Delia D Fundación Hospital La Fe, Regenerative Medicine and Heart Transplantation Unit, Valencia, Spain ; - - 2014
The development of biomaterials for myocardial tissue engineering requires a careful assessment of their performance with regards to functionality and biocompatibility, including the immune response. poly(3-hydroxybutyrate) (PHB), poly(e-caprolactone) (PCL), silk, poly-lactic acid (PLA), and polyamide (PA) scaffolds were generated by electrospinning, and cell compatibility in vitro, and immune response and ...
Aurora Arin B - - 2014
Myocardial infarction (MI) leads to cardiomyocyte death, which triggers an immune response that clears debris and restores tissue integrity. In the adult heart, the immune system facilitates scar formation, which repairs the damaged myocardium but compromises cardiac function. In neonatal mice, the heart can regenerate fully without scarring following MI; ...
Ankrum James A JA 1] Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, - - 2014
The diverse immunomodulatory properties of mesenchymal stem/stromal cells (MSCs) may be exploited for treatment of a multitude of inflammatory conditions. MSCs have long been reported to be hypoimmunogenic or 'immune privileged'; this property is thought to enable MSC transplantation across major histocompatibility barriers and the creation of off-the-shelf therapies consisting ...
Godwin James W JW Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, - - 2014
Salamanders and frogs are distinct orders of Amphibians with very different immune systems during adult life, exhibiting varying potential for scar free repair and regeneration. While salamanders can regenerate a range of body parts throughout all stages of life, regeneration is restricted to early stages of frog development. Comparison of ...
Xu Xinxian X Osteopathy Department, Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, - - 2014
Osteocyte apoptosis is the main manifestation of steroid-induced avascular necrosis of the femoral head (SANFH). STAT1 and caspase 3 participate in the process of apoptosis and STAT1 upregulates the expression of caspase 3. We examined the relationship between the STAT1-caspase 3 pathway and apoptosis in SANFH. All specimens were divided ...
Ikezoe Kohei K Kyoto University Graduate School of Medicine, - - 2014
To the Editor:Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kD lipocalin that is covalently bound to matrix metalloproteinase (MMP)-9 produced by neutrophils (1). NGAL in blood or bronchoalveolar lavage fluid (BALF) may reflect neutrophilic inflammation in the lungs (2, 3), and it is highly induced in injured epithelial cells, including ...
Huang Ying Y Jiangsu Key Laboratory for Biodiversity & Biotechnology and Jiangsu Key Laboratory for Aquatic Crustacean Diseases, College of Life Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210046, PR - - 2014
C-type lectin is one of the pattern-recognition proteins of the non-self-innate immune system in invertebrates. In this study, two novel C-type lectin cDNAs (EsCTL1 and EsCTL2) of Eriocheir sinensis were cloned and characterized. EsCTL1 has 169 amino acids, whereas EsCTL2 has 164 amino acids. These two lectins contain one carbohydrate-recognition ...
Sunaga Fujiko F Laboratory of Infectious Disease, School of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa, 252-5201, Japan, - - 2014
The aim of this study is to determine the efficacy of exoantigens derived from Babesia gibsoni cultures to induce protective immunity against challenge exposure of virulent organisms. An attenuated B. gibsoni Oita strain was maintained in vitro by the microaerophilus stationary phase (MASP) method, and exoantigens-containing supernatant fluids were collected ...
Bullers Sam S University of York, Jack Birch Unit for Molecular Carcinogenesis, York, United Kingdom ; - - 2014
In vivo studies of implanted acellular biological scaffolds in experimental animals have shown constructive remodelling mediated by anti-inflammatory macrophages. Little is known about the human macrophage response to such biomaterials, or the nature of the signalling mechanisms that govern the macrophage phenotype in this environment. The cellular events at the ...
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