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Zhao Yong Y Department of Emergency, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. - - 2014
Carvedilol is a non-selective β-blocker used in the treatment of cardiovascular disease, including myocardial ischemia. The aim of the present study was to investigate the molecular mechanisms underlying the effects of carvedilol on simulated ischemia/reperfusion (SI/R)-induced cardiomyocyte apoptosis in vitro. H9c2 cardiomyocytes were incubated with either a vehicle or an ...
Canna Scott W SW Molecular Immunology and Inflammation Branch, National Institute for Arthritis and Musculoskeletal and Skin Diseases (NIAMS), US National Institutes of Health (NIH), Bethesda, Maryland, - - 2014
Inflammasomes are innate immune sensors that respond to pathogen- and damage-associated signals with caspase-1 activation, interleukin (IL)-1β and IL-18 secretion, and macrophage pyroptosis. The discovery that dominant gain-of-function mutations in NLRP3 cause the cryopyrin-associated periodic syndromes (CAPS) and trigger spontaneous inflammasome activation and IL-1β oversecretion led to successful treatment with ...
Chu Chun-Hsien CH Neuropharmacology Section, National Institutes of Health/National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, - - 2014
Regulatory mechanisms of the expression of interleukin-10 (IL-10) in brain inflammatory conditions remain elusive. To address this issue, we used multiple primary brain cell cultures to study the expression of IL-10 in lipopolysaccharide (LPS)-elicited inflammatory conditions. In neuron-glia cultures, LPS triggered well-orchestrated expression of various immune factors in the following ...
Huang Yun-Ying YY Department of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan 2 Rd, Guangzhou, 510080, - - 2014
Palmitate, a common saturated free fatty acid (FFA), has been demonstrated to induce preadipocyte apoptosis in the absence of adipogenic stimuli, suggesting that preadipocytes may be prone to apoptosis under adipogenic insufficient conditions, like type 2 diabetes mellitus (T2DM). ClC-3, encoding Cl(-) channel or Cl(-)/H(+) antiporter, is critical for cell ...
Yan Xiaofei X Department of Biochemistry and Molecular Biology, Medical School, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China, - - 2014
Excessive reactive oxygen species (ROS) generation has been implicated as one of main agents in ouabain-induced anticancer effect. Unfortunately, the signaling pathways under it are not very clarified. In the present study, we investigated the molecular mechanism involved in ouabain-induced ROS generation and cell apoptosis on human U373MG and U87MG ...
Jian Chenyao C College of Veterinary Medicine, Northwest A & F University, Yangling, Shaanxi, 712100, People's Republic of China, - - 2014
Rotavirus infection is a major cause of diarrhea in children, piglets, calves, and young animals and results in large economic losses. Rotavirus nonstructural glycoprotein 4 (NSP4) serves a key function in viral replication and assembly. NSP4 could induce apoptosis during rotavirus infection, as demonstrated in previous studies. However, the mechanism ...
Hao Ming M Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, No. 23 Youzheng Street, NanGang District, Harbin, Heilongjiang Province, - - 2014
Diabetic retinopathy (DR) is a leading cause of acquired blindness in adults. Previous research has shown that the apoptosis of retinal ganglion cells(RGCs) plays an important role in the initiation and development of diabetic retinopathy. The positive effect of estrogen on the nervous system is currently attracting increasing attention. In ...
Ahn Ji-Hye JH Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, Republic of - - 2014
Ecklonia cava is an abundant brown alga and has been reported to possess various bioactive compounds having anti-inflammatory effect. However, the anticancer effects of dieckol, a major active compound in E. cava, are poorly understood. In the present study, we investigated the anti-tumor activity of dieckol and its molecular mechanism ...
Mollereau Bertrand B Laboratory of Molecular Biology of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France, - - 2014
The canonical role of p53 in preserving genome integrity and limiting carcinogenesis has been well established. In the presence of acute DNA-damage, oncogene deregulation and other forms of cellular stress, p53 orchestrates a myriad of pleiotropic processes to repair cellular damages and maintain homeostasis. Beside these well-studied functions of p53, ...
Zhao Xiaoyang - - 2014
BackgroundDue to the increased application of titanium dioxide nanoparticles (TiO2 NPs) in the food industry and daily life, their potential toxic effects in humans and animals have been investigated. However, very few studies have focused on testicular oxidative stress and/or apoptosis.MethodsIn order to understand the possible molecular mechanisms of testicular ...
Song Xiaodong X Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China; Medicine Research Center, Binzhou Medical University, Yantai, - - 2014
Oxidative stress is an important molecular mechanism underlying lung fibrosis. The mitochondrion is a major organelle for oxidative stress in cells. Therefore, blocking the mitochondrial signalling pathway may be the best therapeutic manoeuver to ameliorate lung fibrosis. Astaxanthin (AST) is an excellent antioxidant, but no study has addressed the pathway ...
Li Fengtao F Orthopedics Department Two, The Second Affiliated Hospital of Xi'an Jiaotong University, Xiwu road NO.157, 710004, Xi An, - - 2014
Spinal cord injury (SCI) is considered to be primarily associated with loss of motor function and leads to activate diverse cellular mechanisms in the central nervous system to attempt to repair the damaged spinal cord tissue. Chemokine Receptor 5 (CCR5), a major co-receptor for macrophage-tropic human immunodeficiency viruses, is expressed ...
Wang Jiong J Department of Pulmonology, Anhui Geriatrics Institute, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, - - 2014
Clearance of apoptotic neutrophils by macrophages is important for both the successful resolution of acute inflammation and homeostasis. However, the dynamic process of phagocytosis of apoptotic neutrophils by macrophages and the fate of macrophages after the ingestion of apoptotic neutrophils has not been well documented. In the present study, we ...
Wang Wen-Ke WK The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, - - 2014
Apoptosis is a key event involved in diabetic cardiomyopathy. The expression of high mobility group box 1 protein (HMGB1) is up-regulated in diabetic mice. However, the molecular mechanism of high glucose (HG)-induced cardiomyocyte apoptosis remains obscure. We aimed to determine the role of HMGB1 in HG-induced apoptosis of cardiomyocytes. Treating ...
Choi H H BK 21 Plus KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu, Republic of - - 2014
In this study, a novel antimicrobial peptide, scolopendin 1, was identified from adult centipedes, Scolopendra subspinipes mutilans using RNA sequencing. Scolopendin 1 exerted an antimicrobial activity without inducing haemolysis of human erythrocytes. In order to understand the antifungal mechanism, a reactive oxygen species (ROS) assay was performed, which indicated that ...
Hong Dan D Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Xiangya Road 87#, Changsha, 410078, - - 2014
Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is emerging as a key contributing factor in atherogenesis, a process in turn known to involve macrophage apoptosis. The aim of this study was to determine the effect of ADMA on macrophage apoptosis, with specific reference to the endoplasmic ...
Karabay Arzu Z AZ Department of Biochemistry, Ankara University Faculty of Pharmacy , Tandogan, Ankara , Turkey - - 2014
Abstract Methylsulfonylmethane (MSM) is a non-toxic, natural organosulfur compound, which is known to possess antioxidant and anti-inflammatory activities. In recent years, MSM has been widely used as a dietary supplement for its beneficial effects against various diseases, especially arthritis. Despite being a popular supplement product, the mechanism of action of ...
Guo Huizhen H The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People's Republic of - - 2014
Ischemic stroke has been confirmed to cause neuronal injury due to its insufficient supply of glucose and oxygen to brain tissue. Previous research has shown that oxidative stress, a result of excessive accumulation of reactive oxygen species (ROS), relates to pathophysiology of ischemic stroke, and causes oxidative damage to biomolecules, ...
Mill C C From the School of Clinical Sciences, University of Bristol, Bristol Royal Infirmary, Bristol, United - - 2014
Apoptosis of vascular smooth muscle cells (VSMCs) contributes to thinning and rupture of the atherosclerotic plaque fibrous cap and is thereby associated with myocardial infarction. Wnt protein activation of β-catenin regulates numerous genes that are associated with cell survival. We therefore investigated Wnt/β-catenin survival signaling in VSMCs and assessed the ...
Ye Alice L AL University of California, Santa - - 2014
In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage ...
Palit Shreyasi S Infectious Diseases & Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, - - 2014
Hesperetin, a flavanone glycoside predominantly found in citrus fruits, exhibits a wide array of biological properties. In the present study hesperetin exhibited a significant cytotoxic effect in human breast carcinoma MCF-7 cells in a concentration- and time-dependent manner without affecting normal (HMEC) as well as immortalized normal mammary epithelial cells ...
Sieck Jochen B JB Novartis Pharma AG, Biologics Process R&D, Basel, Switzerland; Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, - - 2014
In this work, the response and adaption of CHO cells to hydrodynamic stress in laboratory scale bioreactors originating from agitation, sparging and their combination is studied experimentally. First, the maximum hydrodynamic stress, τmax, is characterized over a broad range of operating conditions using a shear sensitive particulate system. Separate stress ...
Ishaq Mohammad M Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology, Chandigarh 160 036, - - 2014
Gambogic acid (GA) is a potent anticancer agent and has been found effective against various types of cancer cells. The present study was addressed to explore the cytotoxic potential of GA and the modulation of autophagy and apoptosis in bladder cancer cells T24 and UMUC3. Bladder cancer cells lines T24 ...
BoseDasgupta Somdeb S Biozentrum, University of Basel, - - 2014
Coronin 1 is a member of the evolutionarily conserved coronin protein family. Coronin proteins are characterized by the presence of a central WD repeat and a C-terminal coiled coil that in coronin 1 is responsible for trimerization. Coronin 1 was identified as a host protein protecting intracellularly residing mycobacteria from ...
Amini Elham E Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, - - 2014
Epilepsy is the most common and chronic neurological disorder characterized by recurrent unprovoked seizures. The key aim in treating patients with epilepsy is the suppression of seizures. An understanding of focal changes that are involved in epileptogenesis may therefore provide novel approaches for optimal treatment of the seizure. Although the ...
Han Yanqiu - - 2014
Objectives Derived from plants, flavonoids have been proven to possess anti-cancer activities. Adriamycin (ADM), an anthracycline antibiotic, is widely applied in the chemotherapy for leukemia; however, it has a side effect of heart damage. This study aims to explore potential anti-leukemia effects of quercetin (Que) and the underlying mechanism. Methods ...
Miao Yi Y Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, P.R. - - 2014
Previous findings have shown that acetycholine (ACh) decreased hypoxia-induced tumor necrosis factor alpha (TNF α) production, thus protected against cardiomyocyte injury. However, whether and how ACh affects TNF α-induced endoplasmic reticulum (ER) stress and cell apoptosis remain poorly defined. This study was aimed at determining the effect of ACh in ...
Zhang Chris Zhiyi CZ Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, China, - - 2014
Background The incidence and mortality of hepatocellular carcinoma (HCC) remain high worldwide. Drug screening from natural plants is one of the potential therapeutic approaches on HCC. Methods The antitumor effect of momordica charantia lectin (MCL) was examined, using MTT, colony formation, AnnexinV/PI staining, western blot and animal model. Results MCL ...
Gao Zhe Z State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093, - - 2014
Strategy on activated T cells is an effective treatment for T cell mediated diseases. By using a synthesized chromone derivative, we examined its effects on the activated T cells. This compound, (Z)-1,3-dihydroxy-9-methyl-13H-benzo[b]chromeno[3,2-f][1,4]oxazepin-13-one (neochromine S5), exhibited immunosuppressive activity in vitro and in vivo. Interestingly, neochromine S5 selectively inhibited proliferation and induced ...
Wen Ying - - 2014
As a marker for oxidative stress and a second messenger in signal transduction, hydrogen peroxide (H2O2) plays an important role in living systems. It is thus critical to monitor the changes in H2O2 in cells and tissues. Here, we developed a highly sensitive and versatile ratiometric H2O2 fluorescent probe (NP1) ...
Yang Long L Department of Biology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E2; State Key Laboratory of Agricultural Microbiology, Key Laboratory of Plant Pathology of Hubei Province, Huazhong Agricultural University, Wuhan 430070, China; - - 2014
The rapid reorganization and polarization of actin filaments (AFs) toward the pathogen penetration site is one of the earliest cellular responses, yet the regulatory mechanism of AF dynamics is poorly understood. Using live-cell imaging in Arabidopsis, we show that polarization coupled with AF bundling involves precise spatiotemporal control at the ...
Nath Siddharth S Department of Biochemistry and Biomedical Sciences, Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada, L8N - - 2014
Cellular stress is a normal part of the aging process and is especially relevant in neurodegenerative disease. Canonical stress responses, such as the heat shock response, activate following exposure to stress, and restore proteostasis through the action of isomerases and chaperones within the cytosol. Through live cell imaging, we demonstrate ...
Vincent Crystal M CM Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada M5S 3G5 - - 2014
Sex differences in immunity are often observed, with males generally having a weaker immune system than females. However, recent data in a sex-role-reversed species in which females compete to mate with males suggest that sexually competitive females have a weaker immune response. These findings support the hypothesis that sexual dimorphism ...
Rochette Luc L Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM) Inserm UMR866, Facultés de Médecine et de Pharmacie - Université de Bourgogne, 7 Bld Jeanne d'Arc 21033 DIJON France. Electronic address: - - 2014
The maintenance of stable extracellular and intracellular iron concentrations requires the coordinated regulation of iron transport into plasma. Iron is a fundamental cofactor for several enzymes involved in oxidation-reduction reactions. The redox ability of iron can lead to the production of oxygen free radicals, which can damage various cellular components. ...
Song Wei W Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, P.R. - - 2014
The present study was designed to investigate the effect of tanshinol on hydrogen peroxide (H2O2)‑induced apoptosis in human umbilical vein endothelial cells (HUVECs), and to determine the underlying mechanisms. HUVECs were pre‑incubated with tanshinol (25‑200 µM) for 24 h, followed by an incubation with 600 µM H2O2 for 6 h. The cell viability was ...
Pérez-Perarnau Alba A Departament de Ciències Fisiològiques II, University of Barcelona, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat - - 2014
A new class of small molecules, with an unprecedented trifluorothiazoline scaffold, were synthesized and their pro-apoptotic activity was evaluated. With an EC50 in the low micromolar range, these compounds proved to be potent inducers of apoptosis in a broad spectrum of tumor cell lines, regardless of the functional status of ...
Goswami Akshra A Department of Biotechnology, Panjab University, Chandigarh 160014, - - 2014
Leukemia is one of the deadliest types of cancer. Lack of effective treatment strategies has resulted in an extensive quest for new therapeutic molecules against it. One such promising molecule is P16, a semi synthetic analog of parthenin which has been extracted from flowering plant Parthenium hysterophorus. This study explores ...
Schlegelmilch Katrin K Orthopedic Center for Musculoskeletal Research, University of Würzburg, Germany. Electronic address: - - 2014
WNT-induced secreted protein 1 (WISP1/CCN4), a member of the CCN protein family, acts as a downstream factor of the canonical WNT signaling pathway. Its expression is known to affect proliferation and differentiation of human mesenchymal stromal cells (hMSCs), which are fundamental for the development and maintenance of the musculoskeletal system. ...
Aslan Mutay M Department of Medical Biochemistry, Akdeniz University Faculty of Medicine, Antalya, Turkey. Electronic address: - - 2014
Endoplasmic reticulum (ER) stress and excessive nitric oxide production via induction of inducible nitric oxide synthase (NOS2) have been implicated in the pathogenesis of neuronal retinal cell death in ocular hypertension. Neutral sphingomyelinase (N-SMase)/ceramide pathway can regulate NOS2 expression, hence this study determined the role of selective neutral sphingomyelinase (N-SMase) ...
Wu Li-Hua LH Department of Pathology, The 2nd Affiliated Hospital of Harbin Medical University, Nangang District, Harbin, 150081, - - 2014
Ionizing radiation (IR) can generate reactive oxygen species (ROS). Excessive ROS have the potential to damage cellular macromolecules including DNA, proteins, and lipids and eventually lead to cell death. In this study, we evaluated the potential of arbutin, a drug chosen from a series of traditional herbal medicine by measuring ...
Li Hai-Ying HY Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University, 2 FuXue Road, Wenzhou 325000, - - 2014
Honokiol, a constituent of Magnolia officinalis, has been reported to possess potent anti-cancer activity through targeting multiple signaling pathways in numerous malignancies including acute myeloid leukemia (AML). However, the underlying mechanisms remain to be defined. Here, we report that honokiol effectively decreased enzyme activity of HDACs and reduced the protein ...
Yu Houyou H Department of Emergency Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, - - 2014
Several studies have reported that microRNA (MIR) is involved in the pathogenesis and progression of ischemic diseases, including cerebral ischemia, and that MIR-22 may inhibit the inflammatory response and cell apoptosis, which contribute to ischemia/reperfusion (I/R) injury. However, the specific function of MIR-22 in cerebral I/R injury remains far from ...
Chen Liming L Department of Hematology, Yantai Yuhuangding Hospital, No.20, Yuhuangding East Road, Yantai, Shandong Province, 264000, People's Republic of - - 2014
Radiation-induced cellular injury is attributed primarily to the harmful effects of free radicals, which play a key role in irradiation-induced apoptosis. In this study, we investigated the radioprotective efficacy of edaravone, a licensed clinical drug and a powerful free radical scavenger that has been tested against γ-irradiation-induced cellular damage in ...
Zhang Yanlin Y From the Research Center of Occupational Medicine, Peking University Third Hospital, Beijing, People's Republic of China (Y.Z., L.G., J.Z.); Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China (Z.W., X.L.); Department of Emergency, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China (P.J.); Department of Oncology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, People's Republic of China (T.G.); and Beijing Institute of Hepatology, Beijing Youan Hospital affiliated with Capital Medical University, Beijing, People's Republic of China - - 2014
Systemic inflammation is a key feature in acid aspiration-induced acute respiratory distress syndrome (ARDS), but the factors that trigger inflammation are unclear. The authors hypothesize that extracellular histones, a newly identified inflammatory mediator, play important roles in the pathogenesis of ARDS. The authors used a hydrochloric acid aspiration-induced ARDS model ...
Jose Shinsmon - - 2014
BackgroundProgression of neurodegenerative diseases occurs when microglia, upon persistent activation, perpetuate a cycle of damage in the central nervous system. Use of mesenchymal stem cells (MSC) has been suggested as an approach to manage microglia activation based on their immunomodulatory functions. In the present study, we describe the mechanism through ...
Tang Bo B Hepatosplenic Surgery Center, Department of General Surgery, Harbin Medical University, Harbin, - - 2014
Objective: The present study aims to investigate the underlying mechanisms accounting for the activities of everolimus to inhibit the growth of vascular smooth muscle cells (VSMCs), which contributes to restenosis. Methods: Primary VSMCs were cultured in media containing smooth muscle growth supplements and incubated with testing agents. Cell proliferation, cell ...
Assis L C LC Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, - - 2014
β-caryophyllene (BCP), a natural bicyclic sesquiterpene present in several essential oils, displays analgesic and anti-inflammatory properties in vitro and in vivo. Astrocytes are a major class of glial cells that regulate extracellular ion balance, repair and scarring processes in the central nervous system (CNS) following neuroinflammatory conditions and traumatic injuries. ...
Damasio Danusa de Castro DD Pós-graduação em Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Paraná, 80215-901, Curitiba, Paraná, - - 2014
It has been demonstrated that the cytotoxic effect of BJcuL, the lectin isolated from Bothrops jararacussu venom, on human gastric carcinoma is accompanied by the inhibition of extracellular matrix adhesion, cytoskeleton disassembly and apoptosis induction. The present study aimed to evaluate the apoptosis mechanisms triggered by the BJcuL interaction with ...
Yang Hsin-Ling HL Institute of Nutrition, China Medical University, Taichung, 40402, - - 2014
Humic acid (HA) in well water is associated with Blackfoot disease and various cancers. Previously, we reported that acute humic acid exposure (25-200 µg/mL for 24 hr) induces inflammation in RAW264.7 macrophages. In this study, we observed that prolonged (72 hr) HA exposure (25-200 µg/mL) induces cell-cycle arrest and apoptosis ...
Picone Pasquale - - 2014
Abstract Neuroblastoma is one of the most frequent extra cranial solid tumors in children. It accounts for 8-10% of all childhood cancer deaths and development of new drugs for its treatment results to be needed. Curcumin (diferuloylmethane) a major active component of tumeric (Curcuma longa) has been shown to exert ...
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