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Vincent Crystal M CM Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada M5S 3G5 - - 2014
Sex differences in immunity are often observed, with males generally having a weaker immune system than females. However, recent data in a sex-role-reversed species in which females compete to mate with males suggest that sexually competitive females have a weaker immune response. These findings support the hypothesis that sexual dimorphism ...
Steelman Andrew J - - 2014
BackgroundAberrant neuroinflammation is suspected to contribute to the pathogenesis of myriad neurological diseases. As such, determining the pathways that promote or inhibit glial activation is of interest. Activation of the surface glycoprotein T-cell immunoglobulin and mucin-domain containing protein 3 (Tim-3) by the lectin galectin-9 has been implicated in promoting innate ...
Zhang Shen S Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Haidian District, Beijing 100193, PR - - 2014
Abstract Tunicamycin (TM) causes accumulation of unfolded protein in ER lumen and introduces from elsewhere ER stress. This study was to assess the apoptosis and autophagy effect induced by TM on HepG2 cells and the role of autophagy in the system. The viability of HepG2 cells was significantly inhibited by ...
Zhang Xiaoning X Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou, 730000, - - 2014
2,4-Dichlorophenol (2,4-DCP) has been widely used to produce herbicides and pharmaceutical intermediates, which exhibits various toxic effects including apoptosis. However, the mechanisms underlying 2,4-DCP-induced apoptosis, especially mediated by endoplasmic reticulum (ER) stress, are still unknown. In the present study, the mouse embryonic fibroblasts (MEFs) were used as an in vitro ...
Hunt Katherine M KM University of Alabama at Birmingham, University of Alabama School of Medicine, 1670 University Blvd., Birmingham, Alabama, 35233, United - - 2014
Significant amounts of arsenic have been found in the groundwater of many countries including Argentina, Bangladesh, Chile, China, India, Mexico, and the United States with an estimated 200 million people at risk of toxic exposure. Although chronic arsenic poisoning damages many organ systems, it usually first presents in the skin ...
Jia Qinghua Q Experimental Center of Medicine, Lanzhou General Hospital of Lanzhou Military, People's Liberation Army, Key Laboratory of Stem Cells and Gene Drug of Gansu Province, 333 Southern Binhe Road, Lanzhou, 730050, China, - - 2014
Lead is a kind of nephrotoxic metal which frequently threats human health. Hepatocyte growth factor (HGF) is a multifunctional growth factor that protects cell apoptosis. In this study, human mesangial cells (HMCs) were treated with a single HGF dose of 20 and 40 μl/ml in order to investigate the effect of ...
Yoon Sun-Ok SO Laboratory of Cellular Immunology, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, 70121, LA, USA, - - 2014
Activating mutations in the NOTCH1 gene are found in over 50 % of T-ALL cases. Since Notch signaling contributes to the leukemia cell survival and growth, targeting Notch signaling using γ-secretase inhibitors (GSI) has been proposed as a molecularly targeted therapy for the treatment of T-ALL. However, not all T-ALL with ...
Kim Seog-Young SY Department of Surgery, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh, PA, 15213, - - 2014
In this study, we attempted to develop a multimodality approach using chemotherapeutic agent mitomycin C, biologic agent tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo-2L), and mild hyperthermia to treat colon cancer. For this study, human colon cancer LS174T, LS180, HCT116 and CX-1 cells were infected with secretory TRAIL-armed adenovirus (Ad.TRAIL) and ...
Jie Zhou Z School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR - - 2014
Triptolide (TP), a major active ingredient extracted from the widely used Chinese herb Tripterygium wilfordii Hook f. (TWHF), has been demonstrated to possess various biological activities. However, the clinical applications of TP are limited by its narrow therapeutic window and severe toxicity. The current study aimed to investigate the roles ...
Wu Gengze G Chongqing Institute of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, China & Boston Children's Hospital, Harvard Medical School, Boston, - - 2014
-Long non-coding RNAs (lncRNAs) recently have been implicated in many biological processes and diseases. Atherosclerosis is a major risk factor for cardiovascular disease. However, the functional role of lncRNAs in atherosclerosis is largely unknown. -We identified lincRNA-p21 as a key regulator of cell proliferation and apoptosis during atherosclerosis. The expression ...
Jones Raasay S RS Trinity College Institute of Neuroscience, Department of Physiology, Trinity College, Dublin 2. Ireland. Electronic address: - - 2014
Microglia are particularly plastic cells which can be shifted from their resting state by numerous factors and adopt distinct phenotypes. The cells are multifunctional, though their main role is probably maintenance of homeostasis. Resting cells are responsible for surveillance, whereas activation induces the cells to adopt neuroprotective or neurodetrimental roles, ...
Zhu Minmin M Department of Anesthesiology, Fudan University Shanghai Cancer Center, No 270 DongAn Road, Shanghai, 200032, People's Republic of China, - - 2014
Hippocampal neuronal oxidative stress and apoptosis have been reported to be involved in cognitive impairment, and angiotensin II could induce hippocampal oxidative stress and apoptosis. Propofol is a widely used intravenous anesthetic agent in clinical practice, and it demonstrates significant neuroprotective activities. In this study, we investigated the mechanism how ...
Santhosh M Sebastin MS Department of Studies in Biochemistry, University of Mysore, Mysore, 570 006, Karnataka, - - 2014
Viper envenomation results in inflammation at the bitten site as well as target organs. Neutrophils and other polymorphonuclear leukocytes execute inflammation resolving mechanism and will undergo apoptosis after completing the task. However, the target specific toxins induce neutrophil apoptosis at the bitten site and in circulation prior to their function, ...
Wang Bin B State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan Univ, Wuxi, Jiangsu, 214122, - - 2014
Consumption of high-fat diet (HFD) is related with increased oxidative stress and dysfunctional mitochondria in many organs. The effects of resveratrol (trans-3,5,4'-trihydroxystilbene) that can protect T lymphocytes in various disease conditions on the HFD-induced apoptosis of CD4(+) CD25(+) CD127(low/-) regulatory T cells (Tregs) were studied, and the possible mechanism was ...
Huang Q Q School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, - - 2014
Apoptosis has essential roles in a variety of cellular and developmental processes. Although the pathway is well studied, how the activities of individual components in the pathway are regulated is less understood. In Drosophila, a key component in apoptosis is Drosophila inhibitor of apoptosis protein 1 (DIAP1), which is required ...
Ma S B SB Walter and Eliza Hall Institute of Medical Research, 1 G Royal Parade, Parkville, Melbourne, Victoria, - - 2014
In non-apoptotic cells, Bak constitutively resides in the mitochondrial outer membrane. In contrast, Bax is in a dynamic equilibrium between the cytosol and mitochondria, and is commonly predominant in the cytosol. In response to an apoptotic stimulus, Bax and Bak change conformation, leading to Bax accumulation at mitochondria and Bak/Bax ...
Chun Jaemoo J Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of - - 2014
In the present study, we investigated the effects of 3-O-β-D-galactopyranosyl-(1 → 2)-[β-D-xylopyranosyl-(1 → 3)]-β-D-glucuronopyranosyl-28-O-[α-L-arabinopyranosyl-(1 → 4)-α-L-arabinopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-β-D-fucopyranosyl] quillaic acid, named compound 1, on the induction of apoptosis and autophagy in human gastric cancer AGS cells. Compound 1, a triterpenoid saponin isolated from the root of Adenophora triphylla var. japonica, effectively inhibited the growth of AGS cells by ...
Wei Teng T College of Veterinary Medicine, Jilin University, Changchun, 130062, Jilin, - - 2014
Oxidative stress is a major component of harmful cascades activated in neurodegenerative disorders. We sought to elucidate possible effects of phillyrin, an active constituent isolated from the Chinese medicinal herb Forsythia suspense, on hydrogen peroxide (H2O2)-induced cell death and determine the underlying molecular mechanisms in neuron-like PC12 cells. By MTT ...
Valério Elisabete E Unidade de Água e Solo, Departamento de Saúde Ambiental, Instituto Nacional de Saúde Dr. Ricardo Jorge. Avenida Padre Cruz, 1649-016 Lisboa, Portugal; Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal. Electronic address: - - 2014
Microcystins (MC) are cyanotoxins occurring globally, known for causing acute hepatotoxicity in humans/animals, tumor promotion in animals and potential carcinogenicity. The mechanism of MC toxicity is considered a multi-pathway process involving the inhibition of protein phosphatases PP1/PP2A and the production of reactive oxygen species (ROS). However, their mechanism of action ...
Wensing Lislaine A LA Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil; Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, - - 2014
Chronic kidney disease (CKD) is an increasingly common condition characterized by progressive loss of functional nephrons leading to renal failure. TGF-β1-induced mesangial cell (MC) phenotype alterations have been linked to the genesis of CKD. Here we show that TGF-β1 regulates TBX3 gene expression in MC. This gene encodes for two ...
Mazzon Emanuela E IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Messina, - - 2014
Spinal cord injury (SCI) occurs following damage to the spinal column. Following trauma, tissue damage is further exacerbated by a secondary damage due to a SCI-activated inflammatory process. Control of leukocytes activity is essential to therapeutic inhibition of the spinal cord damage to ameliorate the patient's conditions. The mechanisms that ...
Ping Mao M Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, PR - - 2014
Background: Paeonol (2'-hydroxy-4'-methoxyacetophenone) is thought to possess a broad range of clinically curative effects that are likely mediated by its anti-inflammatory and antioxidant activities. Aims: To elucidate the efficacy of paeonol's anti-inflammatory and antioxidant activities and the underlying mechanism of paeonol in advanced oxidation protein product (AOPP) stimulation of THP-1 ...
Norouzi Mahnaz M Department of Cellular and Molecular Biology, Faculty of Science, Kharazmi University, Tehran, - - 2014
Recently, much effort has been directed toward the search for compounds that influence apoptosis and to understand their mechanisms of action. Cyclooxygenase (COX)-2 inhibitors may induce apoptosis through the COX-2-independent mechanism via a mitochondrial pathway. In view of the reported antiproliferative activities of two COX-2 inhibitor derivatives (1, 2) in ...
Yen Benjamin B Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York - - 2014
Zaire ebolavirus (EBOV) VP35 is a double-stranded RNA (dsRNA) binding protein that inhibits RIG-I signaling and interferon (IFN)-α/β responses by both dsRNA-binding dependent and independent mechanisms. VP35 also suppresses DC maturation. Here, we define the pathways and mechanisms through which VP35 impairs DC maturation. Wild-type VP35 (VP35-WT) and two well-characterized ...
Dufey Estefanie E University of - - 2014
Increased demand on the protein folding capacity of the endoplasmic reticulum (ER) is a salient feature of secretory cells, a condition that engages an adaptive reaction known as the unfolded protein response (UPR). The UPR regulates protein translation and the expression of numerous target genes that contribute to restore ER ...
Shengyou Yu Y Department of Pediatrics, Guangzhou First People's Hospital, affiliate to Guangzhou Medical University, - - 2014
the objective of this article is to evaluate the role of siRNA-silenced TRPC6 on podocyte autophagy and apoptosis induced by AngII. mouse podocyte cell lines were cultured in vitro. The apoptosis rates of each group were detected using flow cytometry. The expression of LC3-II protein and changes in distribution were ...
Benkhalifa Moncef M Reproductive Medicine & Medical Cytogenetics, Centre of Obstetrics and Gynecology, Refional University Hospital and School of Medicine. Picardie University Jules Verne, Amiens, France. Electronic address: - - 2014
Mitochondria is a powerhouse organelle involved in ATP synthesis, calcium signaling, reactive oxygen species (ROS) by oxidative stress production, cell cycle arrest via apoptosis and sex steroid hormones biosynthesis. Improvement of sperm parameters such as motility, capacitation, acrosome reaction and oocyte interaction, involve regulation of ROS levels by the mitochondria. ...
Zanetti Filippo F Department of Pediatrics, 1211 Geneva, Switzerland; Department of Pathology and Immunology, Medical School, University of Geneva, - - 2014
Nicotine contributes to the onset and progression of several pulmonary diseases. Among the different pathophysiological mechanisms triggered by nicotine, oxidative stress and cell death are reported in several cell types. We found that chronic exposure to nicotine (48h) induced NOX1-dependent oxidative stress and apoptosis in primary pulmonary cells. In a ...
Seo Kyuhwa K College of Pharmacy, Chosun University, Gwangju 501-759, South - - 2014
Methylglyoxal is found in high levels in the blood and other tissues of diabetic patients and exerts deleterious effects on cells and tissues. Previously, we reported that resveratrol, a polyphenol in grapes, induced the expression of Sestrin2 (SESN2), a novel antioxidant protein, and inhibited hepatic lipogenesis. This study investigated whether ...
Li Xue-Tao XT State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, - - 2014
Most anticancer drugs are not able to cross the blood-brain barrier (BBB) effectively while surgery and radiation therapy cannot eradicate brain glioma cells and glioma stem cells (GSCs), hence resulting in poor prognosis with high recurrence rates. In the present study, a kind of multifunctional targeting daunorubicin plus quinacrine liposomes ...
Vincent Crystal M CM Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada - - 2014
A critical task in evolutionary genetics is to explain the persistence of heritable variation in fitness-related traits such as immunity. Ecological factors can maintain genetic variation in immunity, but less is known about the role of other factors, such as antagonistic pleiotropy, on immunity. Sexually dimorphic immunity-with females often being ...
Barker Bethan L - - 2014
Background:Relationships between airway inflammation and respiratory potentially pathogenic microorganisms (PPMs) quantified using quantitative polymerase chain reaction (qPCR) in subjects with COPD are unclear. Our aim was to evaluate mediators of airway inflammation and their association with PPMs in COPD subjects at stable state and during exacerbations. Methods:Sputum from 120 stable ...
Bissoyi Akalabya A Department of Biotechnology and Medical Engineering, National Institute of Technology , Rourkela, India - - 2014
Cryopreservation of mesenchymal stem cells (MSCs) is important because of their commercial applications in the clinical sector. MSCs are vulnerable to cryopreservation-induced apoptosis due to activation of apoptosis-related proteins during thawing. But the relationship between cryopreservation and apoptosis is not well understood. MSCs derived from umbilical cord blood were cryopreserved ...
Dalle Pezze Piero P Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom; Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United - - 2014
Cellular senescence, a state of irreversible cell cycle arrest, is thought to help protect an organism from cancer, yet also contributes to ageing. The changes which occur in senescence are controlled by networks of multiple signalling and feedback pathways at the cellular level, and the interplay between these is difficult ...
Ghosh Mistuni M Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland CA 94609, - - 2014
Curcumin is a plant-derived polyphenol that displays antitumor properties. Incubation of cultured SF-767 glioma cells with curcumin gave rise to intense intranuclear foci of curcumin fluorescence. In vitro studies revealed that nuclear homing by curcumin is not a result of DNA/chromatin binding. On the other hand, curcumin fluorescence colocalized with ...
Leung Anna M AM Department of Surgery, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, - - 2014
The generation of reactive oxygen species (ROS) and their resultant oxidative damage is a common pathway for gastric mucosal injury. Developing strategies to protect the gastric epithelium against oxygen free radical damage is of profound pathophysiological interest. We have previously shown caspase-mediated apoptosis as a major cause of ROS-induced cell ...
Yang Canchao C Ministry of Education Key Laboratory for Tropical Plant and Animal Ecology, College of Life Sciences, Hainan Normal University, Haikou, 571158, Hainan Province, - - 2014
Parasites may, in multi-parasite systems, block the defenses of their hosts and thus thwart host recognition of parasites by frequency-dependent selection. Nest defenses as frontline may block or promote the subsequent stage of defenses such as egg recognition. We conducted comparative studies of the defensive strategies of a host of ...
Grencis Richard K RK Faculty of Life Sciences, University of Manchester, Manchester, - - 2014
Immune responses to gastrointestinal nematodes have been studied extensively for over 80 years and intensively investigated over the last 30-40 years. The use of laboratory models has led to the discovery of new mechanisms of protective immunity and made major contributions to our fundamental understanding of both innate and adaptive responses. In ...
Gil-Ramírez Yolanda Y Departamento de Microbiología y Parasitología e Instituto de Salud Tropical, Universidad de Navarra, 31008 Pamplona (Spain). Electronic address: - - 2014
Brucellosis is a worldwide extended zoonosis caused by Brucella spp. These gram-negative bacteria are not readily detected by innate immunity, a virulence-related property largely linked to their surface lipopolysaccharide (LPS). The role of the LPS lipid A and O-polysaccharide in virulence is well known. Moreover, mutation of the glycosyltransferase gene ...
Fredensborg B L BL Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark - - 2014
A trade-off between resource-specialization and the breadth of the ecological niche is one of the most fundamental biological characteristics. A true generalist (Jack-of-all-trades) displays a broad ecological niche with little resource specialization while the opposite is true for a resource-specialist that has a restricted ecological niche that it masters. Parasites ...
Moeller Mark M Institute for Biostatistics and Informatics in Medicine und Ageing Research, Rostock University Medical Center, Rostock, - - 2014
Traditionally, biomarkers of aging are classified as either pro-longevity or antilongevity. Using longitudinal data sets from the large-scale inbred mouse strain study at the Jackson Laboratory Nathan Shock Center, we describe a protocol to identify two kinds of biomarkers: those with prognostic implication for lifespan and those with longitudinal evidence. ...
Williams Gareth R GR Chemistry Research Laboratory, Department of Chemistry; 2 Nuffield Department of Surgical Sciences, John Radcliffe Hospital; and 3 Department of Statistics; University of Oxford, Oxford OX1 2JD, England, - - 2014
There is currently no paradigm in immunology that enables an accurate prediction of how the immune system will respond to any given agent. Here we show that the immunological responses induced by members of a broad class of inorganic crystalline materials are controlled purely by their physicochemical properties in a ...
Suchy Dariusz D Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia in Katowice, Katowice, Poland. Electronic address: - - 2014
The immune system of humans is strongly affected by the processes of aging and what is called immunosenescence and inflammaging. Aging processes are also associated with altered macrophage functions and their ability to undergo differential activation. As a result, the risk of macrophage-related disorders like atherosclerosis is increased in the ...
Kemgang T S TS Department of Animal Biochemistry, National Dairy Research Institute, 132001, Karnal, Haryana state, India; Department of Food Science/Nutrition, National School of AgroIndustrial Sciences, University of Ngaoundere, PO Box: 455, Ngaoundere, Adamaoua, - - 2014
The mechanism by which probiotic lactobacilli affect the immune system is strain specific. As the immune system is multi-compartmental system, each strain has his way to interact with it and induce a visible and quantifiable effect. This review summarises the interplay existing between the host immune system, with emphasis on ...
Ilinskaya A N AN Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, Maryland - - 2014
Nanoparticle interactions with various components of immune system are determined by their physicochemical properties such as size, charge, hydrophobicity and shape. Nanoparticles can be engineered to either specifically target the immune system or to avoid immune recognition. Nevertheless, identifying their unintended impacts on the immune system and understanding the mechanisms ...
Kubli Shawn P SP Department of Biology, University of Western Ontario, London, Ontario N6A 5B7, - - 2014
Abstract In short-lived animals, innate immunity is an important component of fitness and quality. Although receivers cannot generally assess a signaler's immune function directly, sexually selected displays such as birdsong may reflect past or current condition. We investigated the degree to which song complexity and consistency, thought to reflect condition ...
Lyte Marc M Department of Immunotherapeutics and Biotechnology; School of Pharmacy; Texas Tech University Health Sciences Center; Abilene, TX - - 2014
The ability of microorganisms, whether present as commensals within the microbiota or introduced as part of a therapeutic regimen, to influence behavior has been demonstrated by numerous laboratories over the last few years. Our understanding of the mechanisms that are responsible for microbiota-gut-brain interactions is, however, lacking. The complexity of ...
Zak Daniel E DE Seattle BioMed, Seattle, Washington 98109; email: - - 2014
Systems-level analysis of biological processes strives to comprehensively and quantitatively evaluate the interactions between the relevant molecular components over time, thereby enabling development of models that can be employed to ultimately predict behavior. Rapid development in measurement technologies (omics), when combined with the accessible nature of the cellular constituents themselves, ...
Moreno-García Miguel M Centro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Avda. Universidad 655. Col. Sta. María Ahuacatitlán, 62100 Cuernavaca, Morelos, México. Electronic address: - - 2014
The insect immune response strategy has generally been considered bipolar: either resistance or death. Lately, a much broader and subtler landscape has emerged: occurrence of tolerance and resistance has been described as a host-regulated immune response. However, little is known about the interplay between the immune response strategy mounted by ...
Lewis Christina M - - 2014
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the neuromuscular system and does not have a known singular cause. Genetic mutations, extracellular factors, non-neuronal support cells, and the immune system have all been shown to play varied roles in clinical and pathological disease progression. The therapeutic plasticity of mesenchymal ...
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