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Ma Yihua Y Department of Marine Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China. Electronic address: - - 2014
A new water-soluble polysaccharide (SEP-2), with a molecular weight of 6.78×10(5)Da, was isolated from Strongylocentrotus nudus eggs under the extraction conditions optimized by response surface methodology (RSM). Preliminary characterization of SEP-2 was performed by HPSEC and GC-MS, indicating that SEP-2 could be a d-glucan containing a (1→4)-linked d-Glcp backbone with ...
Stinchcombe Jane C JC Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, - - 2014
Recent findings on the behaviour of the centrosome at the immunological synapse suggest a critical role for centrosome polarization in controlling the communication between immune cells required to generate an effective immune response. The features observed at the immunological synapse show parallels to centrosome (basal body) polarization seen in cilia ...
Elawadli I I Department of Pathobiology, Ontario Veterinary College, University of Guelph, 419 Gordon Street, Guelph, Ontario, N1G 2W1 - - 2014
Lactic acid bacteria (LAB) are of interest because of their potential to modulate immune responses. The effects of LAB range from regulation to stimulation of the immune system. A series of studies were performed in vitro to study the effects of six lactic acid bacteria (LAB), Lactobacillus helveticus LH-2, Lactobacillus ...
Lee Shin Ae SA Department of Microbiology, Yonsei University College of Medicine, Seoul, - - 2014
With growing accounts of inflammatory diseases such as sepsis, greater understanding the immune system and the mechanisms of cellular immunity have become primary objectives in immunology studies. High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is implicated in various aspects of the innate immune system as ...
Fu Mei-Ya MY Department of Gastroenterology, The Fourth Affiliated Hospital of the Medical College of Jinan University, Guangzhou Red Cross Hospital, Guangzhou, Guangdong 510220, P.R. - - 2014
Autophagy is a metabolic process that is important in fibrogenesis, in which cellular components are degraded by lysosomal machinery. Transforming growth factor β1 (TGF‑β1) is a potent fibrogenic cytokine involved in liver fibrosis; however, it remains elusive whether autophagy is regulated by TGF‑β1 in this process. In the present study, the ...
Lo Ying-Chun YC aDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA bChang-Gung Transplantation Institute, Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan *These authors contributed equally to the writing of this - - 2014
In this review, we discuss the recent advances with regard to the mammalian target of rapamycin (mTOR) signaling pathway and focus on how this pathway modulates immune responses. Overall, these insights provide important clues in terms of strategically integrating mTOR and metabolic inhibitors into transplantation rejection protocols. mTOR is regulated ...
Su Chang C Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA, - - 2014
Oxidative stress has long been implicated in the pathogenesis of various neurodegenerative disorders such as Alzheimer's disease and stroke. While high levels of oxidative stress are generally associated with cell death, a slight rise of reactive oxygen species (ROS) levels can be protective by "preconditioning" cells to develop a resistance ...
Zhao Peng P Health Management Center, Hangzhou Sanatorium of PLA, Hangzhou, Zhejiang 310007, P.R. - - 2014
Quercetin can inhibit the growth of cancer cells with the ability to act as a 'chemopreventer'. Its cancer-preventive effect has been attributed to various mechanisms, including the induction of cell-cycle arrest and/or apoptosis, as well as its antioxidant functions. Quercetin can also reduce adipogenesis. Previous studies have shown that quercetin ...
Mhaidat Nizar M NM Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid 22110, - - 2014
Elucidation of the molecular mechanisms by which 5-fluorouracil (5-FU) induces apoptosis is required in order to understand the resistance of colorectal cancer (CRC) cells to 5-FU. In the current study, 5-FU-induced apoptosis was assessed using the propidium iodide method. Involvement of protein kinase C (PKC) was assessed by evaluating the ...
Xiao Xiao X Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. - - 2014
Gliomas are one of the most common types of malignant tumors worldwide, however, an effective therapeutic strategy not yet been fully determined. The present study aimed to investigate the anti-glioma activity and underlying mechanisms of pregnenolone, which originates from cholesterol and is metabolized into important steroid hormones in the body. ...
Dhingra Nikhil N 1] The Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA [2] Columbia University College of Physicians and Surgeons, New York, New York, - - 2014
Atopic dermatitis (AD) is associated with the effects of T helper type 2 (Th2) and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating molecular changes during AD; IL-17A's role, however, has yet to be ...
Travers Jeffrey B JB 1] Richard L. Roudebush VA Medical Center, Indianapolis, Indiana, USA [2] Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, - - 2014
Patients with atopic dermatitis (AD) are commonly colonized/infected with Staphylococcus aureus, and this bacterium is known to worsen the dermatitis. In this issue, Brauweiler et al. demonstrate a newly discovered mechanism by which Th2 cytokines involved in AD augment the toxicity of the lytic staphylococcal protein alpha toxin. This review ...
Junkins Robert D RD Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, - - 2014
Pseudomonas aeruginosa, an opportunistic pathogen, is the leading cause of morbidity and mortality in immune-compromised individuals. Maintaining the integrity of the respiratory epithelium is critical for an effective host response to P. aeruginosa. Given the close spatial relationship between mast cells and the respiratory epithelium, and the importance of tightly regulated ...
Pitt Jonathan M JM INSERM Unit U1015, Gustave Roussy Cancer Campus, 98405 Villejuif, France; Faculté de Médecine, Université Paris Sud-XI, 94276 Le Kremlin Bicêtre, - - 2014
Exosomes are nanometric membrane vesicles of late endosomal origin released by most, if not all, cell types as a means of sophisticated intercellular communication. A multitude of studies showed how exosomes can mediate and regulate immune responses against tumors. Dendritic cell-derived exosomes (Dex) have received much attention as immunotherapeutic anticancer ...
Sachewsky Nadia N Institute of Medical Science, University of Toronto, Medical Science Building, 1 King's College Circle, Toronto, ON M5S 1A8, - - 2014
Cyclosporin A (CsA) has direct effects on neural stem and progenitor cells (together termed neural precursor cells; NPCs) in the adult central nervous system. Administration of CsA in vitro or in vivo promotes the survival of NPCs and expands the pools of NPCs in mice. Moreover, CsA administration is effective ...
Johannesson Bjarki B Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, 00015, - - 2014
Allergic contact dermatitis (ACD) is triggered by an aberrant hyperinflammatory immune response to innocuous chemical compounds and ranks as the world's most prevalent occupational skin condition. Although a variety of immune effector cells are activated during ACD, regulatory T (Treg) cells are crucial in controlling the resulting inflammation. Insulin-like growth ...
Long Kristin K From the Section on Trauma and Acute Care Surgery (L.P., C.M., A.B.), Division of General Surgery (K.L.), Department of Microbiology, Immunology and Molecular Genetics (J.W., M.W.), and Department of Pathology (D.W.), University of Kentucky, Lexington, - - 2014
Transfusion-related immunomodulation consists of both proinflammatory and anti-inflammatory responses after transfusion of blood products. Stored red blood cells (RBCs) suppress human T-cell proliferation in vitro, but the mechanism remains unknown. We hypothesized that cytokine synthesis by T cells may be inhibited when stored RBCs are present and that suppression between ...
Fruci D D Paediatric Haematology/Oncology Department, IRCCS, Ospedale Pediatrico Bambino Gesù, 00165, Rome, - - 2014
Major histocompatibility complex (MHC) class I molecules present antigenic peptides on the cell surface to alert natural killer (NK) cells and CD8(+) T cells for the presence of abnormal intracellular events, such as virus infection or malignant transformation. The generation of antigenic peptides is a multistep process that ends with ...
Tsunoda Toshiyuki T Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka, - - 2014
We have previously reported the crucial roles of oncogenic Kirsten rat sarcoma viral oncogene homolog (KRAS) in inhibiting apoptosis and disrupting cell polarity via the regulation of phosphodiesterase 4 (PDE4) expression in human colorectal cancer HCT116 cells in three-dimensional cultures (3DC). Herein we evaluated the effects of resveratrol, a PDE4 ...
Ishikawa Mami M Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, Kobe, - - 2014
Macrophages play important roles in antitumor immunity, and immunotherapy with the group-specific component protein-derived macrophage-activating factor (GcMAF) has been reported to be effective in patients with various types of cancers. However, in macrophage research, it is important to properly evaluate macrophage activity. U937 macrophages were induced by 12-O-tetradecanoyl-13-phorbolacetate (TPA). The ...
Inagawa Hiroyuki H Faculty of Medicine, Kagawa University, FROM KAGAWA Bio Lab., Hayashi-cho, Takamatsu-shi, Kagawa-ken, Japan Control of Innate Immunity Technology Research Association, Takamatsu-shi, Kagawa-ken, Japan - - 2014
Many publications show that macrophages are closely involved in etiology of diseases, such as cancer, diabetes, arteriosclerosis, and Alzheimer's disease. Recent studies show that waste products (e.g. dead cells, denatured proteins, oxidized lipids, and advanced glycation end-products) are the real causative agents of lifestyle-associated diseases. From the standpoint of health ...
Lim Ji-Hong JH Department of Applied Biochemistry, College of Biomedical & Health Science, Research Institute of Inflammatory Disease, Konkuk University, Chungju, South - - 2014
Few studies have been performed on the anticancer activity of hispidin, a phenolic compound produced from the medicinal mushroom Phellinus linteus. Herein, we studied hispidin-induced apoptosis, which is associated with the generation of reactive oxygen species (ROS) in colon cancer cells. Hispidin was found to reduce cell viability both in ...
Kim Hyung Sook HS College of Pharmacy, Chungbuk National University, 52 Naesoodong, Heungduk, Cheongju, Chungbuk, 361-763, South - - 2014
4-O-methylhonokiol (MH) is known to inhibit inflammation by partially understood mechanisms. Here, the anti-inflammatory mechanisms of MH were examined using enzymatic, cellular, and animal assays. In enzymatic assays, MH inhibited COX-2 activity with an IC50 of 0.062 μM, and also COX-1 with an IC50 of 2.4 μM. In cellular assays, MH was ...
Xiong Shunbin S Department of Genetics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, 77030, - - 2014
The mitochondria-mediated caspase activation pathway is a major apoptotic pathway characterized by mitochondrial outer membrane permeabilization (MOMP) and subsequent release of cytochrome c into the cytoplasm to activate caspases. MOMP is regulated by the Bcl-2 family of proteins. This pathway plays important roles not only in normal development, maintenance of ...
Taverniti Valentina - - 2014
Intestinal inflammation is a natural process crucial for the maintenance of gut functioning. However, abnormal or prolonged inflammatory responses may lead to the onset of chronic degenerative diseases, typically treated by means of pharmacological interventions. Dietary strategies for prevention of inflammation are a safer alternative to pharmacotherapy. Anthocyanins and other ...
Leopold Wager C M CM 1] Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA [2] The South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, - - 2014
Macrophages are innate immune cells that possess unique abilities to polarize toward different phenotypes. Classically activated macrophages are known to have major roles in host defense against various microbial pathogens, including fungi, while alternatively activated macrophages are instrumental in immune-regulation and wound healing. Macrophages in the lungs are often the ...
Kanagavelu S S 1] Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA [2] Division of Gastroenterology, Department of Medicine, F. Widjaja Foundation, Inflammatory Bowel and Immunology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, - - 2014
Gastrointestinal mucosa reserves abundant Th17 cells where host response to commensal bacteria maintains Th17-cell generation. Although functional heterogeneity and dynamic plasticity of Th17 cells appear to be involved in chronic inflammatory disorders, how their plasticity is regulated in intestinal mucosa is unknown. Here we show that innate TRIF signaling regulates ...
Ge Wei W 1National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences , Dongdan Santiao 5 #, Dongcheng district, Beijing , - - 2014
Lysosomes perform a range of functions, some of which, such as degradation, are common to all cell types. Others, such as secretion or lysosomal exocytosis, are more specialised and tend to involve fusion of this organelle with the cell surface to release its contents. This review describes lysosomal regulation of ...
Park Hyojung H Sookmyung Women's University, Seoul, Korea, Republic of ; - - 2014
Aim: Lipopolysaccharide (LPS) is considered a prominent pathogenic factor in inflammatory bone diseases. LPS challenge contributes to the production of ROS in diverse inflammatory diseases. However, its mechanism remains to be clarified in bone. Thus, we investigated the critical mechanism of ROS in LPS-induced osteoclastogenesis and bone loss. Results: Antioxidant ...
Sun Yongkun Y a Group of Environmental Adaptation Science, Faculty of Environmental Earth Science, Hokkaido University , Sapporo , - - 2014
Despite extensive research on copper toxicity the mechanisms involved are not fully characterized. There have been many recent reports concerning the relationship between epigenetic factors and cell metabolism, but the effects of copper exposure on epigenetic factors have not been investigated. In this study, an in vitro culture system was ...
Jost Nils H NH Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, - - 2014
Cytomegalovirus (CMV) establishes lifelong chronic infection in its host with mostly asymptomatic or only mild disease, but under immunosuppressive conditions the virus can reactivate and infection can cause life-threatening disease. CMV has evolved several mechanisms to escape from host's immunity, allowing persistence of the virus. Until now, it remains elusive ...
Cho In-Hee - - 2014
Eotaxin proteins are a potential therapeutic target in treating the peribronchial eosinophilia associated with allergic airway diseases. Since inflammation is often associated with an increased generation of reactive oxygen species (ROS), oxidative stress is a mechanistically imperative factor in asthma. Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity and newly ...
Denis Marie C - - 2014
Cranberry fruit has been reported to have high antioxidant effectiveness that is potentially linked to its richness in diversified polyphenolic content. The aim of the present study is to determine the role of cranberry polyphenolic fractions in oxidative stress, inflammation and mitochondrial functions using intestinal Caco-2/15 cells. The combination ofHPLC ...
Neumann Christian C German Rheumatism Research Centre Berlin, an Institute of the Leibniz-Association, 10117 Berlin, Germany Department of Rheumatology and Clinical Immunology, Medical Clinic I, Gastroenterology, and Department of Microbiology and Hygiene, Charité University Hospital, 10117 Berlin, - - 2014
Secretion of the immunosuppressive cytokine interleukin (IL) 10 by effector T cells is an essential mechanism of self-limitation during infection. However, the transcriptional regulation of IL-10 expression in proinflammatory T helper (Th) 1 cells is insufficiently understood. We report a crucial role for the transcriptional regulator Blimp-1, induced by IL-12 ...
Viaud S S Institut National de la Santé et de la Recherche Médicale, U1015, Gustave Roussy, Villejuif, France. Université Paris-Sud, Kremlin Bicêtre, - - 2014
Distinct cytotoxic agents currently used in the oncological armamentarium mediate their clinical benefit by influencing, directly or indirectly, the immune system in such a way that innate and adaptive immunity contributes to the tumoricidal activity. Now, we bring up evidence that both arms of anticancer immunity can be triggered through ...
Ernst Matthias M Cell signalling and cell death, Walter and Eliza Hall Institute for Cancer Research - - 2014
Emerging evidence suggests that cytokines produced by inflammatory cells act as rheostats to link the degree of wounding and local inflammation to epithelial cell survival, proliferation, and metabolism that collectively underpin the repair response. Among these cytokines, the GP130 family, which encompasses among others interleukin (IL)-6 and -11, plays a ...
Vieira-Potter Victoria J VJ Department of Nutrition and Exercise Physiology, University of Missouri, Columbia MO 65211, - - 2014
The adipose tissue is an active endocrine organ that harbors not only mature and developing adipocytes but also a wide array of immune cells, including macrophages, a key immune cell in determining metabolic functionality. With adipose tissue expansion, M1 pro-inflammatory macrophage infiltration increases, activates other immune cells, and affects lipid ...
Hojyo Shintaro S Laboratory for Homeostatic Network,Osteoimmunology, Deutsches Rheuma-Forschungszentrum, 10117 Berlin, - - 2014
The humoral immune response, also called the antibody-mediated immune response, is one of the main adaptive immune systems. The essential micronutrient zinc (Zn) is known to modulate adaptive immune responses, and dysregulated Zn homeostasis leads to immunodeficiency. However, the molecular mechanisms underlying this Zn-mediated modulation are largely unknown. Here, we ...
Zheng Ying Y 1] Cancer Research Institute, Central South University, Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Key Laboratory of Carcinogenesis, Ministry of Health, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, China [2] Center for Medical Research, Second Xiangya Hospital, Central South University, Changsha, - - 2014
Epstein-Barr virus (EBV) infection contributes to tumorigenesis of various human malignancies including nasopharyngeal carcinoma (NPC). EBV triggers innate immune and inflammatory responses partly through Toll-like receptor (TLR) signaling. Lactoferrin (LF), with its anti-inflammatory properties, is an important component of the innate immune system. We previously reported that LF protects human ...
Aranda F F 1] Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, INSERM U1138, Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [3] Metabolomics and Cell Biology Platforms, Villejuif, - - 2014
cis-Diamminedichloroplatinum(II) (CDDP), which is mostly referred to as cisplatin, is a widely used antineoplastic. The efficacy of cisplatin can be improved by combining it with the vitamin B6 precursor pyridoxine. Here, we evaluated the putative synergistic interaction of CDDP with pyridoxine in the treatment of an orthotopic mouse model of ...
Cazareth Julie - - 2014
Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflammatory cytokines with central or peripheral origin after various insults. ...
Mosovsky Kara K Regional Center of Excellence in Emerging Diseases and Bioterrorism, Department of Microbiology, Immunology, and Pathology, Colorado State University, Ft. Collins, CO, - - 2014
Burkholderia pseudomallei, a facultative intracellular pathogen, causes severe infections and is inherently refractory to many antibiotics. Previous studies from our group have shown that interferon-gamma (IFN-γ) interacts synergistically with the antibiotic ceftazidime to kill bacteria in infected macrophages. The present study aimed to identify the underlying mechanism of that interaction. ...
Lam Roselind S RS Oral Health Cooperative Research Centre, Melbourne Dental School, The University of Melbourne, Melbourne, Victoria 3010, Australia; - - 2014
The role of the macrophage in the immunopathology of periodontitis has not been well defined. In this study, we show that intraoral inoculation of mice with Porphyromonas gingivalis resulted in infection, alveolar bone resorption, and a significant increase in F4/80(+) macrophages in gingival and submandibular lymph node tissues. Macrophage depletion ...
Sunke Rajnikanth R Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India. - - 2014
We report a true MCR involving the reaction of N-(prop-2-ynyl)quinoxalin-2-amine derivatives with 2-iodoanilines and tosyl azide in the presence of 10 mol% of CuI and Et3N in DMSO to afford the pre-designed hybrid molecules containing quinoxaline framework linked with a benzimidazole nucleus. The MCR proceeds in the absence of any ...
Matos Marina N MN Cátedra de Inmunología and Instituto de Estudios de la Inmunidad Humoral (IDEHU), CONICET-UBA, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. Instituto de Microbiología y Parasitología Médica, IMPaM (UBA-CONICET) and Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, UBA, Buenos Aires, - - 2014
In this work we immunized mice with DNA encoding full-length Tc52, or its amino- or carboxy-terminal domain (N- and C-term, respectively) carried by attenuated Salmonella as a DNA delivery system. As expected, Salmonella-mediated DNA delivery resulted in low antibody titers and a predominantly Th1 response, as shown by the ratio ...
Toma Ilario De ID University Vita-Salute San Raffaele, Milan, - - 2014
High Mobility Group Box 1 (HMGB1) is a small nuclear protein with two functions. In the nucleus, it helps to wrap DNA around nucleosomes. When secreted, it recruits inflammatory cells and induces cytokine production. Before HMGB1 is secreted from inflammatory cells, it relocates to the cytoplasm, which partially or totally ...
Ji Haofeng H Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, - - 2014
Hepatic ischemia-reperfusion injury (IRI), an innate immunity-driven inflammation response, occurs in multiple clinical settings including liver resection, transplantation, trauma, and shock. TIM-4, the only TIM protein not expressed on T cells, is found on macrophages and dendritic cells. The regulatory function of macrophage TIM-4 in the engulfment of apoptotic/necrotic bodies ...
Rivellese Felice F Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, - - 2014
Basophils are circulating granulocytes, best known as effector cells in allergic reactions. Recent studies in mice suggest that they might also participate in the suppression of chronic inflammation. The aim of this study was to assess the ability of purified human basophils to modulate monocyte responses upon IL-33 and IgE ...
Zhan Qingling Q Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, 210009, Jiangsu Province, People's Republic of - - 2014
Recently, quantum dots (QDs) have been widely applied in biological and biomedical fields such as cell labeling, living tissue imaging, and photodynamic therapy because of their superior optical properties. Meanwhile, the potential biological negative effects and/or toxic effects of QDs have become increasingly important, especially the cytotoxicity caused by QDs. ...
Sendoel Ataman A 1] Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190 CH-8057 Zurich, Switzerland [2] Division of Hematology, University Hospital Zurich, Raemistrasse 190 CH-8091 Zurich, Switzerland - - 2014
Microtubule-targeting chemotherapeutics induce apoptosis in cancer cells by promoting the phosphorylation and degradation of the anti-apoptotic BCL-2 family member MCL1. The signalling cascade linking microtubule disruption to MCL1 degradation remains however to be defined. Here, we establish an in vivo screening strategy in Caenorhabditis elegans to uncover genes involved in ...
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