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Suffredini A F AF Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, - - 2014
Linking human physiology to inflammatory mechanisms discovered in vitro or in animal models is essential to determine their importance. Innate immunity underlies many of these inflammatory responses in health and disease. Bacterial endotoxin is the quintessential trigger of innate immune responses. When administered to humans, endotoxin has been an important ...
Lee Suyeon S Bioland R&D Center, Cheonan, Chungnam, - - 2014
Portulaca oleracea extracts, known as Ma Chi Hyun in the traditional Korean medicine, show a variety of biomedical efficacies including those in anti-inflammation and anti-allergy. In this study, we investigate the protective activity of the P. oleracea extracts against UVB-induced damage in human epithelial keratinocytes and fibroblasts by several apoptosis-related tests. ...
Lin Hugo - - 2014
BackgroundMammalian target of rapamycin (mTOR) inhibitors, such as sirolimus and its derivative, everolimus, are potent immunosuppressive and antiproliferative drugs. Inflammatory diseases are characterized by immunological dysfunction, and monocyte recruitment underlies the mechanism of cell damage. Chemokines attract inflammatory cells to sites of inflammation. Interleukin-8 (IL-8/CXCL8); the monocyte chemoattractant protein-1 (MCP-1/CCL2); ...
Rylance Jamie J Liverpool School of Tropical Medicine, Respiratory Infection , Pembroke Place , Liverpool, United Kingdom, L3 5QA , 0044 1517053712 , Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi, University of Liverpool, Respiratory Medicine, University Hospital Aintree, Liverpool, United Kingdom ; - - 2014
Background Three billion people are exposed to household air pollution from biomass fuel use. Exposure is associated with higher incidence of pneumonia, and possibly tuberculosis. Understanding mechanisms underlying these defects would improve preventive strategies. Methods We used human alveolar macrophages obtained from healthy Malawian adults exposed naturally to household air ...
Herz Corinna C Institute for Environmental Health Sciences and Hospital Infection Control, Freiburg University Medical Center, Freiburg, - - 2014
In contrast to cancer cells, most normal human cells have no or low telomerase levels which makes it an attractive target for anti-cancer drugs. The small molecule sulforaphane from broccoli is known for its cancer therapeutic potential in vitro and in vivo. In animals and humans it was found to ...
Krug Sebastian S S Krug, Dept. of Gastroenterology, University of Marburg, Marburg, - - 2014
Pancreatic neuroendocrine neoplasms (PNENs) constitute a rare tumour entity, and prognosis and treatment options depend on tumour hallmarks such as angiogenesis, proliferation rate and resistance to apoptosis. Molecular pathways that determine the malignant phenotype are still insufficiently understood and have limited the use of effective combination therapies in the past. ...
Ammerdorffer Anne A Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Department of Bacteriology and TSEs, Central Veterinary Institute, Lelystad, The - - 2014
 Infection with Coxiella burnetii can lead to acute and chronic Q fever. Toll-like receptors (TLR)1, TLR2, TLR4, TLR6, NOD1, NOD2 and the MAP-kinases are central in the innate immune response against micro-organisms, but little is known about their role in the recognition of C. burnetii in humans.  Human peripheral blood ...
Cereijo Rubén R Departament de Bioquímica i Biologia Molecular, Institute of Biomedicine (IBUB), University of Barcelona, and CIBER Fisiopatología de la Obesidad y Nutrición , Barcelona, Catalonia , - - 2014
Evidence from rodents established an important role of brown adipose tissue (BAT) in energy expenditure. Moreover, to sustain thermogenesis, BAT has been shown to be a powerful sink for draining and oxidation of glucose and triglycerides from blood. The potential of BAT activity in protection against obesity and metabolic syndrome ...
Li Ping P Department of Plastic Surgery, The Third Xiang-Ya Hospital, Central South University, Changsha, - - 2014
Hypertrophic scarring leads to a deformed appearance and contracted neogenetic tissue, resulting in physiological and psychological problems for patients. Millions of people suffer these discomforts each year. Emerging evidence has reported that miRNA contributed to hypertrophic scarring or keloid formation. In this study, nine hypertrophic scar samples and the matched ...
Cubillos-Zapata Carolina C Tumor Immunology Laboratory, IdiPAZ, La Paz Hospital, 28046 Madrid, Spain; Innate Immunity Group, IdiPAZ, La Paz Hospital, 28046 Madrid, - - 2014
Endotoxin tolerance (ET) is a state of reduced responsiveness to endotoxin stimulation after a primary bacterial insult. This phenomenon has been described in several pathologies, including sepsis, in which an endotoxin challenge results in reduced cytokine production. In this study, we show that the NFκ L chain enhancer of activated ...
Busca Aurelia A Departments of Pathology and Laboratory Medicine and Biochemistry, Microbiology and Immunology and Infectious Disease & Vaccine Research Centre, Research Institute, Children's Hospital of Eastern Ontario, and Ottawa Hospital Research Institute, University of Ottawa, Ontario, - - 2014
Resistance to apoptosis is an important characteristic that human macrophages acquire during differentiation from monocytes. However, the intracellular mechanisms that mediate the development of resistance are not well understood. We have used M-CSF-stimulated primary human monocytes and PMA-treated THP1 cells to study apoptosis resistance during differentiation of human macrophages. Our ...
Lemaître Cécile C CNRS, UMR 8122, Institut Gustave Roussy, Villejuif, 94805, France Université Paris-Sud, Orsay, 91405, France Université Paris Denis Diderot, Sorbonne Paris-Cité, 75013 Paris, - - 2014
Endogenous retroviruses are the remnants of past retroviral infections that are scattered within mammalian genomes. In humans, most of these elements are old degenerate sequences that have lost their coding properties. The HERV-K(HML2) family is an exception: it recently amplified in the human genome and corresponds to the most active ...
Lin Hongyu H Department of Biotechnology, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, China; Laboratory of Molecular Virology and Immunology, College of Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China; Hebei Engineering and Technology Research Center of Veterinary Biotechnology, Baoding 071001, - - 2014
Human CD83 is type I transmembrane glycoprotein, mainly expressed on mature dendritic cells (DCs), so it was first described as a molecular marker for mature DC. However, increasing evidence has demonstrated that CD83 is also an immunomodulatory molecule either its membrane-bound CD83 (mCD83) or soluble CD83 (sCD83) released from DCs. ...
Valencia Jaris J Department of Cell Biology, Faculty of Medicine, Complutense University, Madrid, - - 2014
Wnt5a is a secreted pleiotropic glycoprotein produced in an inflammatory state by a wide spectrum of ubiquitous cell populations. Recently, we demonstrated that Wnt5a skews the differentiation of human monocyte derived dendritic cells (moDCs) to a tolerogenic functional state. In this study we focus our interest on the role of ...
Morato Camila I CI Tropical Pathology and Public Health Institute, Federal University of Goiás, Goiânia, Goiás, - - 2014
Although Leishmania (Viannia) braziliensis is the most prevalent species that cause American tegumentary leishmaniasis (ATL), the immune response against this parasite has been poorly investigated. Upon activation, macrophages produce a series of pro-inflammatory molecules, including the lipid mediator leukotriene B4 (LTB4). LTB4 has been shown to enhance several macrophage functions, ...
McGovern Naomi N Institute of Cellular Medicine, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK; Singapore Immunology Network, Agency for Science Technology and Research (A-Star), 8A Biomedical Grove, Immunos, Singapore - - 2014
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1(+)CLEC9A(+) DCs and CD1c(+) DCs are murine CD103(+) DCs and CD64(-)CD11b(+) DCs. In addition, human tissues also contain CD14(+) cells, currently designated as DCs, ...
Folco Eduardo J EJ Cardiovascular Medicine, Brigham and Women's - - 2014
Rationale: Inflammation drives atherogenesis. Animal and human studies have implicated interleukin (IL)-1β in this disease. Moderate hypoxia, a condition that prevails in the atherosclerotic plaque, may conspire with inflammation and contribute to the evolution and complications of atherosclerosis through mechanisms that remain incompletely understood. Objective: This study investigated the links ...
Choi Hye Jin HJ Laboratory of Mucosal Exposome and Biomodulation, Department of Biomedical Sciences, Pusan National University School of Medicine, Yangsan, South - - 2014
Carrageenan (CGN), a widely used food additive, has been shown to injure the epithelial barrier in animal models. This type of damage is a clinical feature of inflammatory bowel disease (IBD) in humans. In the present study, the effects of CGN on pro-apoptotic responses associated with macrophage inhibitory cytokine 1 ...
Tsai Ming-Kai MK Division of Nephrology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, - - 2014
Chemokines play essential roles during inflammatory responses and in pathogenesis of inflammatory diseases. Monocyte chemotactic protein-1 (MCP-1) is a critical chemokine in the development of atherosclerosis and acute cardiovascular syndromes. MCP-1, by its chemotactic activity, causes diapedesis of monocytes from the lumen to the subendothelial space that leads to atherosclerotic ...
Rumbo Carlos C Department of Microbiology, Complejo Hospitalario Universitario A Coruña-INIBIC, La Coruña, - - 2014
Acinetobacter baumannii is an extracellular opportunistic human pathogen that is becoming increasingly problematic in hospitals. In the present study, we demonstrated that the A. baumannii Omp33-36 KDa protein (Omp33-36) is a porin that acts as a channel for the passage of water. The protein is found on the cell surface ...
Baldwin William M WM 3rd aDepartment of Immunology, Lerner Research Institute, Cleveland Clinic bSchool of Health Sciences, Cleveland State University, Cleveland, Ohio, - - 2014
Experimental models have contributed enormously to basic immunology. However, the use of reductionist experiments has produced results that are not always successfully translated into the clinic. Recently, incorporation of more realistic clinical parameters in experimental designs has produced new insights relevant to cardiac transplantation. Experiments in mice have provided crucial ...
He Ping-Ping PP Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China; School of Nursing, University of South China, Hengyang, Hunan 421001, - - 2014
Accumulating evidence suggests that microRNA-590 (miR-590) has protective effects on cardiovascular diseases, but the mechanism is unknown. Interestingly, previous studies from our laboratory and others have shown that macrophage-derived lipoprotein lipase (LPL) might accelerate atherosclerosis by promoting lipid accumulation and inflammatory response. However, the regulation of LPL at the post-transcriptional ...
Keightley Maria-Cristina MC Australian Regenerative Medicine Institute, Monash University, Clayton 3800, Victoria, Australia. Electronic address: - - 2014
The outcome following injury can be healing, repair or regeneration, all of which initiate within a resolving inflammatory response. Regeneration, comprising the complete anatomical and functional restoration of lost tissue with minimal residual consequence of injury, is the outcome that most holistically restores prior function. Leukocytes are recognized as playing ...
Valencia-Pacheco Guillermo G Laboratorio de Inmunología, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, Mexico. Electronic address: - - 2014
Crucial to the defense against Leishmania is the ability of the host to mount a cell-mediated immune response capable of controlling and/or eliminating the parasite. The composition of the cell populations recruited in the early phase of the infection seems to be essential for defining the infection outcomes. The signals ...
Bisht Kavita K Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD, - - 2014
Sepsis is associated with abnormal host immune function in response to pathogen exposure, including endotoxin (lipopolysaccharide; LPS). Cytokines play crucial roles in the induction and resolution of inflammation in sepsis. Therefore, the primary aim of this study was to investigate the effects of endogenous tetrapyrroles, including biliverdin (BV) and unconjugated ...
Raffetto Joseph D JD Vascular Surgery Division, VA Boston Healthcare System, West Roxbury, MA, USA Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA - - 2014
Chronic venous leg ulcers (VLU) affect around 1% of the adult population in the Western world. The impact of VLU is both social and economic, with significant expenditures on active venous ulcers to provide medical treatment and eventual healing. At the core of VLU is venous hypertension which affects the ...
Campbell Laura L The Healing Foundation Centre, Faculty of Life Sciences, University of Manchester, Manchester, - - 2014
Efficient local monocyte/macrophage recruitment is critical for tissue repair. Recruited macrophages are polarised towards classical (pro-inflammatory) or alternative (pro-healing) activation in response to cytokines, with tight temporal regulation crucial for efficient wound repair. Estrogen acts as a potently anti-inflammatory regulator of cutaneous healing. However, understanding of estrogen/estrogen receptor contribution to ...
King Alice A Laboratory for Regenerative Wound Healing, Division of Pediatric, General, Thoracic and Fetal Surgery, Cincinnati Children's Hospital Medical Center , Cincinnati, - - 2014
Significance: Postnatal wounds heal with characteristic scar formation. In contrast, the mid-gestational fetus is capable of regenerative healing, which results in wound repair that is indistinguishable from uninjured skin. However, the underlying mechanisms of fetal regenerative phenotype are unknown. Recent Advances: The potent anti-inflammatory cytokine, interleukin-10 (IL-10), plays an essential ...
Willenborg Sebastian S Department of Dermatology, University of Cologne, Cologne, - - 2014
Restoration of skin integrity and homeostasis following injury is a vital process. Wound healing disorders, including chronic skin ulcers and pathological scarring, are of major clinical impact. The current therapeutic approaches are often not sufficient. The development of novel efficient therapies requires a thorough understanding of the underlying molecular mechanisms. ...
Yoon Hyunho H R&D Center, Cellbiotech Co. Ltd., Gimpo, - - 2014
Probiotics are live microorganisms that confer a health benefit on the host. Duolac-Gold is a mixture of seven probiotic bacteria containing three species of Bifidobacteria, two species of Lactobacillus, and Streptococcus thermophilus. The aim of this study was to assess the anti-inflammatory effects of Duolac-Gold in an inflammatory bowel disease ...
Ingle John W JW University of Pittsburgh Voice Center, Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, - - 2014
Steroids are used for the treatment of laryngitis in vocal performers and other individuals despite the absence of evidence demonstrating their impact on vocal fold inflammation. Our objective was to examine laryngeal secretion cytokine inflammatory profile changes associated with corticosteroid treatment in a human phonotrauma model. Prospective, individual, randomized, double-blinded, ...
Hurdayal Ramona R International Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component and Institute of Infectious Diseases and Molecular Medicine (IIDMM), Division of Immunology, University of Cape Town, Cape Town, South - - 2014
Murine models of Leishmania major infection in the 1980's revealed two distinct, counter-regulatory populations of CD4(+) T helper (Th) cells, delineated Th1 and Th2, and their archetypal cytokines, interferon gamma (IFN-γ) and interleukin (IL)-4/IL-13, which promoted resistance/susceptibility to infection, respectively. However, the introduction of global cytokine-deficient mice in the 1990's ...
Wu Yu-Sheng YS College of Life Science, National Taiwan University Taipei, - - 2014
We consider that from the wound to the healing process, the physiology point key to linkage of the process is still unclear. The process from inflammation to the wound healing is divided into three phases: (1) inflammation process, (2) tissue formation, and (3) tissue remodeling. The inflammation program includes cell ...
Parlato Marianna M Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. - - 2014
The intestinal epithelium constitutes a dynamic physical barrier segregating the luminal content from the underlying mucosal tissue. Following injury, the epithelial integrity is restored by rapid migration of intestinal epithelial cells (IECs) across the denuded area in a process known as wound healing. Hence, through a sequence of events involving ...
Nelson M M Biomedical Science Department, DSTL, Porton Down, Salisbury SP4 0JQ, - - 2014
The common marmoset (Callithrix jacchus) is increasingly being utilised as a nonhuman primate model for human disease, ranging from autoimmune to infectious disease. In order to fully exploit these models, meaningful comparison to the human host response is necessary. Commercially available reagents, primarily targeted to human cells, were utilised to ...
Minciullo Paola Lucia PL 0000-0002-3010-3815 Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy ; Policlinico Universitario, Via Consolare Valeria, 98125 Messina, - - 2014
Benzene represents an ubiquitous pollutant both in the workplace and in the general environment. Health risk and stress posed by benzene have long been a concern because of the carcinogenic effects of the compound which was classified as a Group 1 carcinogen to humans and animals. There is a close ...
Menck Kerstin K Department of Hematology and Oncology, University Medical Center - - 2014
Human macrophages are involved in a plethora of pathologic processes ranging from infectious diseases to cancer. Thus they pose a valuable tool to understand the underlying mechanisms of these diseases. We therefore present a straightforward protocol for the isolation of human monocytes from buffy coats, followed by a differentiation procedure ...
Janeklang Somkid S Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand E-mail : - - 2014
Cholangiocarcinoma (CCA) is a fatal cancer with poor prognosis and less than 10% of CCA patients can be offered surgical cure. Conventional chemotherapy results in unfavorable outcomes. At present, plant-derived compounds are gaining interest as potential cancer therapeutics, particularly for treatment-refractory cancers. In this study, antitumor activity of tiliacorinine, the ...
Zhang Yuan Y State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, - - 2014
CD4+ T helper cells regulate appropriate cellular and humoral immune responses to a wide range of pathogens and get involved in many diseases progress. The balance of the earliest determined CD4+ T helper cell subsets, Th1 and Th2, play an important role in allergy and autoimmune diseases. During the research, ...
Temme Sebastian - - 2013
Inflammation results in the recruitment of neutrophils and monocytes, which is crucial for the healing process. In the present study, we used (19)F MRI to monitor in vivo the infiltration of neutrophils and monocytes from the onset of inflammation to the resolution and healing phase. Matrigel, with or without LPS, ...
Lu Ling - - 2013
During the acute liver injury, immune responses are provoked into eliciting inflammation in the acute phase. In the healing phase, the inflammation is terminated for wound healing and restoration of immune homeostasis. In this study, we sought to address how regulatory T cells (Tregs) are involved in the progression of ...
Gao J-H JH Division of Peptides Related with Human Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. shcqcdmed@163.com; - - 2013
The mammalian gastrointestinal (GI) mucosa is a rapidly self-renewing tissue in the body, and its integrity is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. Polyamines are shown to play an important role in the regulation of gastrointestinal mucosal growth and healing after injury under ...
Kemmerly Thomas - - 2013
To review recent developments in the field of gastroduodenal mucosal defense. Research in the field of gastroduodenal mucosal defense has focused on continued elucidation of molecular mechanisms that protect the mucosa and influence healing at the cellular level. Review of literature over the past year reveals focus on familiar processes ...
Raynaud A - - 2013
Honey is well known for its wound healing properties although the cellular and molecular mechanisms underlying honey-stimulated healing process are still poorly understood. The present study was intended to characterize the stimulation of Raw 264.7 murine macrophages in response to thyme honey. Honey induces significant increase in PGE2 production, and ...
Neurath M F - - 2013
Healing of the inflamed mucosa (mucosal healing) is an emerging new goal for therapy and predicts clinical remission and resection-free survival in inflammatory bowel diseases (IBDs). The era of antitumor necrosis factor (TNF) antibody therapy was a remarkable progress in IBD therapy and anti-TNF agents led to mucosal healing in ...
Novak Margaret L - - 2013
Macrophages are essential for the efficient healing of numerous tissues, and they contribute to impaired healing and fibrosis. Tissue repair proceeds through overlapping phases of inflammation, proliferation, and remodeling, and macrophages are present throughout this progression. Macrophages exhibit transitions in phenotype and function as tissue repair progresses, although the precise ...
Hopkins Brittney C - - 2013
Immune function early in life can be influenced by parental effects and the environment, but it remains unclear how these two factors may interact to influence immunocompetence. We evaluated maternal and environmental contributions to offspring healing ability in a viviparous reptile, the northern watersnake (Nerodia sipedon). We measured wound healing ...
Taylor Samuel A - - 2013
Meniscal tears are relatively common injuries sustained by athletes and non-athletes alike and have far reaching functional and financial implications. Studies have clearly demonstrated the important biomechanical role played by the meniscus. Long-term follow-up studies of post-menisectomy patients show a predisposition toward the development of degenerative arthritic changes. As such, ...
Schuppan Detlef D Institute of Molecular and Translational Medicine and Department of Medicine I, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany. - - 2013
Fibrosis is an intrinsic response to chronic injury, maintaining organ integrity when extensive necrosis or apoptosis occurs. With protracted damage, fibrosis can progress toward excessive scarring and organ failure, as in liver cirrhosis. To date, antifibrotic treatment of fibrosis represents an unconquered area for drug development, with enormous potential but ...
Campbell Laura L The Healing Foundation Centre, Faculty of Life Sciences, The University of Manchester, Manchester, - - 2013
Chronic nonhealing wounds in the elderly population are associated with a prolonged and excessive inflammatory response, which is widely hypothesized to impede healing. Previous studies have linked alterations in local L-arginine metabolism, principally mediated by the enzymes arginase (Arg) and inducible nitric oxide synthase (iNOS), to pathological wound healing. Over ...
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