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Bahraoui Elmostafa - - 2014
BackgroundIn HIV-1 infected patients, production of interleukin-10 (IL-10), a highly immunosuppressive cytokine, is associated with progression of infection toward AIDS. HIV-1 Tat protein, by interacting with TLR4-MD2 at the membrane level, induces IL-10 production by primary human monocytes and macrophages. In the present study we evaluated the effect of the ...
Aslani Ferial F Department of Anatomy and Cell Biology, Justus-Liebig-University of Giessen, 35392 Giessen, - - 2014
Does high mobility group box protein 1 (HMGB1) regulate inflammatory reactions in a rat model of experimental autoimmune orchitis (EAO)? HMGB1 appears to be involved in regulating inflammatory reactions in testes, as HMGB1 is translocated from testicular cells during the course of EAO and blocking its action by ethyl pyruvate ...
Banda Nirmal K - - 2014
BackgroundThe complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising magnetic resonance imaging (MRI) contrast agent. However, dextran SPIO has been associated with significant number of complement-related side effects in patients ...
Ward S T ST Centre for Liver Research & NIHR Birmingham Biomedical Research Unit, Level 5 Institute for Biomedical Research, University of Birmingham, Vincent Drive, Birmingham B15 2TT, - - 2014
Background:Regulatory T cells (Treg) are enriched in human colorectal cancer (CRC) where they suppress anti-tumour immunity. The chemokine receptor CCR5 has been implicated in the recruitment of Treg from blood into CRC and tumour growth is delayed in CCR5-/- mice, associated with reduced tumour Treg infiltration.Methods:Tissue and blood samples were ...
Villa Valentina V Laboratory of Pharmacology, Dept. of Internal Medicine, and Center of Excellence for Biomedical Research (CEBR), University of Genova, 16132, Genoa, - - 2014
Activation of microglia is a central event in the atypical inflammatory response occurring during prion encephalopathies. We report that the prion protein fragment encompassing amino acids 90-231 (PrP90-231), a model of the neurotoxic activity of the pathogenic prion protein (PrP(Sc)), causes activation of both primary microglia cultures and N9 microglial ...
Jin Jun-O JO Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: - - 2014
Although some immune modulatory effects of fucoidan have been elucidated, the effects of fucoidan on the apoptosis and activation of human neutrophils have not been investigated. In this study, we demonstrated that fucoidan purified from the brown seaweed Undaria pinnatifilda delays spontaneous apoptosis of human neutrophils and induces their activation. ...
Ou Yang Y Columbia University, United - - 2014
Although p53 is frequently mutated in human cancers, about 80% of human melanomas retain wild-type p53. Here, we report that PHGDH, the key metabolic enzyme that cata-lyzes the rate-limiting step of serine biosynthesis pathway, is a target of p53 in human melanoma cells. p53 suppresses its expression and inhibits de ...
Cai Xin X Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA. Electronic address: - - 2014
The innate immune system uses pattern recognition receptors such as RIG-I and NLRP3 to sense pathogen invasion and other danger signals. Activation of these receptors induces robust signal transduction cascades that trigger the production of cytokines important for host protection. MAVS and ASC are essential adaptor proteins downstream of RIG-I ...
Banerjee Debashish - - 2014
MUC1 is a transmembrane mucin highly expressed in the stomach. While extensive research has uncovered many of its roles in cancer, knowledge about the functions of MUC1 in normal tissues is limited. Here we showed that acetylsalicylic acid (Aspirin, ASA) upregulated MUC1/Muc1 expression in the gastric mucosa of humans and ...
Chinetti-Gbaguidi Giulia G INSERM U1011, Institut Pasteur de Lille, 1, Rue du Professeur Calmette, BP 245, Lille 59019, - - 2014
Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. In atherosclerotic lesions, macrophages respond to various environmental stimuli, such as modified lipids, cytokines, and senescent erythrocytes, which can modify their functional phenotypes. The results of studies on human atherosclerotic plaques demonstrate that the relative proportions of macrophage subsets ...
Shi Hengliang H Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, People's Republic of China; Department of Clinical Medicine, The Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu, People's Republic of - - 2014
Ubiquitin ligase Nrdp1 (neuregulin receptor degradation protein 1) plays important roles in multiple physiological process because it can ubiquitinate various substrates such as ErbB3, BRUCE, MyD88, C/EBPβ, and Parkin, and so forth. In addition to the physiological function, it was also found to be involved in tumor progression. It has ...
Sha Wenwen W Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China; Baylor Institute for Immunology Research, Baylor Scott & White Health Service, Dallas, TX - - 2014
Inflammasomes are multiprotein platforms that activate caspase-1, which leads to the processing and secretion of the proinflammatory cytokines IL-1β and IL-18. Previous studies demonstrated that bacterial RNAs activate the nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3 (NLRP3) inflammasome in both human and murine macrophages. Interestingly, only mRNA, but neither tRNA ...
Li Lingyin L Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, - - 2014
Agonists of mouse STING (TMEM173) shrink and even cure solid tumors by activating innate immunity; human STING (hSTING) agonists are needed to test this therapeutic hypothesis in humans. The endogenous STING agonist is 2'3'-cGAMP, a second messenger that signals the presence of cytosolic double-stranded DNA. We report activity-guided partial purification ...
Wang Juan J State Key Laboratory of Organ Failure Research, Key Laboratory of Transcriptomics and Proteomics, Ministry of Education of China, Key Laboratory of Proteomics of Guangdong Province, Southern Medical University, Guangzhou, China; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, - - 2014
Trauma/hemorrhagic shock is associated with morbidity and mortality due to dysregulated inflammation, which is driven in part by monocytes/macrophages stimulated by injury-induced release of damage-associated molecular pattern (DAMP) molecules. MRP8/MRP14 is an endogenous DAMP involved in various inflammatory diseases, though its mechanism of action is unclear. Circulating MRP8/MRP14 levels in ...
García-Gareta Elena E RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood HA6 2RN, UK. Electronic address: - - 2014
Recent studies show that apoptosis affects surrounding tissue, playing a role in diseases such as fibrosis, a significant global disease burden. Elucidating the mechanisms by which the different apoptotic cells present during fibrotic wound healing affect their environment would enable development of new therapies. We describe here a simple, rapid, ...
Wang Jihong J State Key Lab of Agrobiotechnology, Key Lab of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, 100193, Beijing, People's Republic of China, - - 2014
Prion diseases are fatal neurodegenerative diseases characterized by spongiform change, neuronal loss, and gliosis involving microglial activation in the central nervous system. Microglial activation is thought to play a key role in the pathogenesis of prion disease; however, the molecular mechanisms underlying prion-induced microglial activation are not well understood. The ...
de Pinho Rosa Teixeira RT Laboratório de Imunologia Clínica, Av. Brasil 4365 - Manguinhos, Rio de Janeiro, CEP 21040-360, Brasil. Electronic address: - - 2014
Matrix metalloproteinases (MMPs) constitute a large family of Zn(2+) and Ca(2+) dependent endopeptidases implicated in tissue remodeling and chronic inflammation. MMPs also play key roles in the activation of growth factors, chemokines and cytokines produced by many cell types, including lymphocytes, granulocytes, and, in particular, activated macrophages. Their synthesis and ...
Johansson Maria E ME From the Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden (M.E.J., A.M.L., L.F., Z.-q.Y., G.K.H.); and Department of Physiology, Institute of Neuroscience and Physiology (M.E.J., M.A.U.), Department of Rheumatology and Inflammation Research, Institute of Medicine (A.B., A.A., U.I.), and Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine (L.F.), The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. - - 2014
Cholinergic pathways of the autonomic nervous system are known to modulate inflammation. Because atherosclerosis is a chronic inflammatory condition, we tested whether cholinergic signaling operates in this disease. We have analyzed the expression of the α7 nicotinic acetylcholine receptor (α7nAChR) in human atherosclerotic plaques and studied its effects on the ...
Costa M A MA Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal; Instituto de Biologia Molecular e Celular da Universidade do Porto (IBMC), Porto, - - 2014
The normal development of placenta relies essentially on a balanced proliferation, differentiation and apoptosis of cytotrophoblasts. These processes are tightly regulated by several hormones, cytokines, lipids and other molecules and anomalies in these events are associated with gestational complications. The cation channel transient receptor potential vanilloid 1 (TRPV1) is expressed ...
Ishii Noriko N Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, - - 2014
Nucleic acid-sensing TLRs are involved in both antimicrobial immune responses and autoimmune inflammation. TLR8 is phylogenetically and structurally related to TLR7 and TLR9, which undergo proteolytic processing in the endolysosomes to generate functional receptors. Recent structural analyses of human TLR8 ectodomain and its liganded form demonstrated that TLR8 is also ...
Adolph Elizabeth J EJ a Department of Chemical and Biomolecular Engineering , Vanderbilt University , Nashville , TN , - - 2014
Lysine-derived polyurethane scaffolds (LTI-PUR) support cutaneous wound healing in loose-skinned small animal models. Due to the physiological and anatomical similarities of human and pig skin, we investigated the capacity of LTI-PUR scaffolds to support wound healing in a porcine excisional wound model. Modifications to scaffold design included the addition of ...
Sun Jian-Guo JG Zhejiang University, Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zijinggang Campus, Hangzhou, PR China; Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou, PR - - 2014
ABT-737 is a novel anti-apoptotic Bcl-2 family protein inhibitor with high affinity to Bcl-2, Bcl-xl and Bcl-w but relatively low affinity to Mcl-1/A1. Therefore, high level Mcl-1 usually confers human tumor cells resistance to ABT-737. At the present study, we observed that clitocine can induce apoptosis in six tested human ...
Hagi-Pavli E E Bart's and the London School of Medicine and Dentistry, Queen Mary University, United Kingdom. Electronic address: - - 2014
Oral healthcare products are well tolerated and while adverse occurrences are rare there is still a need to explore the interaction between these products and the oral mucosa. This study assessed the effects of oral healthcare ingredients: sodium lauryl sulphate (SLS), a detergent; cinnamic aldehyde (CA), a flavouring agent; and ...
Alegado Rosanna A RA Department of Oceanography, Center for Microbial Oceanography: Research and Education, Sea Grant College, University of Hawai'i Mānoa, Honolulu, Hawaii - - 2014
Animals evolved in seas teeming with bacteria, yet the influences of bacteria on animal origins are poorly understood. Comparisons among modern animals and their closest living relatives, the choanoflagellates, suggest that the first animals used flagellated collar cells to capture bacterial prey. The cell biology of prey capture, such as ...
Suffredini A F AF Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, - - 2014
Linking human physiology to inflammatory mechanisms discovered in vitro or in animal models is essential to determine their importance. Innate immunity underlies many of these inflammatory responses in health and disease. Bacterial endotoxin is the quintessential trigger of innate immune responses. When administered to humans, endotoxin has been an important ...
Lee Suyeon S Bioland R&D Center, Cheonan, Chungnam, - - 2014
Portulaca oleracea extracts, known as Ma Chi Hyun in the traditional Korean medicine, show a variety of biomedical efficacies including those in anti-inflammation and anti-allergy. In this study, we investigate the protective activity of the P. oleracea extracts against UVB-induced damage in human epithelial keratinocytes and fibroblasts by several apoptosis-related tests. ...
Génot Elisabeth E Université de Bordeaux, F-33000 Bordeaux, France; INSERM U1045, F-33000 Bordeaux, France; European Institute of Chemistry and Biology, 2 rue Robert Escarpit, 33 600 Pessac, France. Electronic address: - - 2014
Podosomes and invadopodia (collectively known as invadosomes) are small, F-actin-rich protrusions that are located at points of cell-ECM contacts and endow cells with invasive capabilities. So far, they have been identified in human or murine immune (myelomonocytic), vascular and cancer cells. The overarching reason for studying invadosomes is their connection ...
Lin Hugo - - 2014
BackgroundMammalian target of rapamycin (mTOR) inhibitors, such as sirolimus and its derivative, everolimus, are potent immunosuppressive and antiproliferative drugs. Inflammatory diseases are characterized by immunological dysfunction, and monocyte recruitment underlies the mechanism of cell damage. Chemokines attract inflammatory cells to sites of inflammation. Interleukin-8 (IL-8/CXCL8); the monocyte chemoattractant protein-1 (MCP-1/CCL2); ...
Rylance Jamie J Liverpool School of Tropical Medicine, Respiratory Infection , Pembroke Place , Liverpool, United Kingdom, L3 5QA , 0044 1517053712 , Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi, University of Liverpool, Respiratory Medicine, University Hospital Aintree, Liverpool, United Kingdom ; - - 2014
Background Three billion people are exposed to household air pollution from biomass fuel use. Exposure is associated with higher incidence of pneumonia, and possibly tuberculosis. Understanding mechanisms underlying these defects would improve preventive strategies. Methods We used human alveolar macrophages obtained from healthy Malawian adults exposed naturally to household air ...
Herz Corinna C Institute for Environmental Health Sciences and Hospital Infection Control, Freiburg University Medical Center, Freiburg, - - 2014
In contrast to cancer cells, most normal human cells have no or low telomerase levels which makes it an attractive target for anti-cancer drugs. The small molecule sulforaphane from broccoli is known for its cancer therapeutic potential in vitro and in vivo. In animals and humans it was found to ...
Krug Sebastian S S Krug, Dept. of Gastroenterology, University of Marburg, Marburg, - - 2014
Pancreatic neuroendocrine neoplasms (PNENs) constitute a rare tumour entity, and prognosis and treatment options depend on tumour hallmarks such as angiogenesis, proliferation rate and resistance to apoptosis. Molecular pathways that determine the malignant phenotype are still insufficiently understood and have limited the use of effective combination therapies in the past. ...
Ammerdorffer Anne A Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Department of Bacteriology and TSEs, Central Veterinary Institute, Lelystad, The - - 2014
 Infection with Coxiella burnetii can lead to acute and chronic Q fever. Toll-like receptors (TLR)1, TLR2, TLR4, TLR6, NOD1, NOD2 and the MAP-kinases are central in the innate immune response against micro-organisms, but little is known about their role in the recognition of C. burnetii in humans.  Human peripheral blood ...
Cereijo Rubén R Departament de Bioquímica i Biologia Molecular, Institute of Biomedicine (IBUB), University of Barcelona, and CIBER Fisiopatología de la Obesidad y Nutrición , Barcelona, Catalonia , - - 2014
Evidence from rodents established an important role of brown adipose tissue (BAT) in energy expenditure. Moreover, to sustain thermogenesis, BAT has been shown to be a powerful sink for draining and oxidation of glucose and triglycerides from blood. The potential of BAT activity in protection against obesity and metabolic syndrome ...
Li Ping P Department of Plastic Surgery, The Third Xiang-Ya Hospital, Central South University, Changsha, - - 2014
Hypertrophic scarring leads to a deformed appearance and contracted neogenetic tissue, resulting in physiological and psychological problems for patients. Millions of people suffer these discomforts each year. Emerging evidence has reported that miRNA contributed to hypertrophic scarring or keloid formation. In this study, nine hypertrophic scar samples and the matched ...
Cubillos-Zapata Carolina C Tumor Immunology Laboratory, IdiPAZ, La Paz Hospital, 28046 Madrid, Spain; Innate Immunity Group, IdiPAZ, La Paz Hospital, 28046 Madrid, - - 2014
Endotoxin tolerance (ET) is a state of reduced responsiveness to endotoxin stimulation after a primary bacterial insult. This phenomenon has been described in several pathologies, including sepsis, in which an endotoxin challenge results in reduced cytokine production. In this study, we show that the NFκ L chain enhancer of activated ...
Busca Aurelia A Departments of Pathology and Laboratory Medicine and Biochemistry, Microbiology and Immunology and Infectious Disease & Vaccine Research Centre, Research Institute, Children's Hospital of Eastern Ontario, and Ottawa Hospital Research Institute, University of Ottawa, Ontario, - - 2014
Resistance to apoptosis is an important characteristic that human macrophages acquire during differentiation from monocytes. However, the intracellular mechanisms that mediate the development of resistance are not well understood. We have used M-CSF-stimulated primary human monocytes and PMA-treated THP1 cells to study apoptosis resistance during differentiation of human macrophages. Our ...
Lemaître Cécile C CNRS, UMR 8122, Institut Gustave Roussy, Villejuif, 94805, France Université Paris-Sud, Orsay, 91405, France Université Paris Denis Diderot, Sorbonne Paris-Cité, 75013 Paris, - - 2014
Endogenous retroviruses are the remnants of past retroviral infections that are scattered within mammalian genomes. In humans, most of these elements are old degenerate sequences that have lost their coding properties. The HERV-K(HML2) family is an exception: it recently amplified in the human genome and corresponds to the most active ...
Lin Hongyu H Department of Biotechnology, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, China; Laboratory of Molecular Virology and Immunology, College of Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China; Hebei Engineering and Technology Research Center of Veterinary Biotechnology, Baoding 071001, - - 2014
Human CD83 is type I transmembrane glycoprotein, mainly expressed on mature dendritic cells (DCs), so it was first described as a molecular marker for mature DC. However, increasing evidence has demonstrated that CD83 is also an immunomodulatory molecule either its membrane-bound CD83 (mCD83) or soluble CD83 (sCD83) released from DCs. ...
Valencia Jaris J Department of Cell Biology, Faculty of Medicine, Complutense University, Madrid, - - 2014
Wnt5a is a secreted pleiotropic glycoprotein produced in an inflammatory state by a wide spectrum of ubiquitous cell populations. Recently, we demonstrated that Wnt5a skews the differentiation of human monocyte derived dendritic cells (moDCs) to a tolerogenic functional state. In this study we focus our interest on the role of ...
Morato Camila I CI Tropical Pathology and Public Health Institute, Federal University of Goiás, Goiânia, Goiás, - - 2014
Although Leishmania (Viannia) braziliensis is the most prevalent species that cause American tegumentary leishmaniasis (ATL), the immune response against this parasite has been poorly investigated. Upon activation, macrophages produce a series of pro-inflammatory molecules, including the lipid mediator leukotriene B4 (LTB4). LTB4 has been shown to enhance several macrophage functions, ...
McGovern Naomi N Institute of Cellular Medicine, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK; Singapore Immunology Network, Agency for Science Technology and Research (A-Star), 8A Biomedical Grove, Immunos, Singapore - - 2014
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1(+)CLEC9A(+) DCs and CD1c(+) DCs are murine CD103(+) DCs and CD64(-)CD11b(+) DCs. In addition, human tissues also contain CD14(+) cells, currently designated as DCs, ...
Folco Eduardo J EJ Cardiovascular Medicine, Brigham and Women's - - 2014
Rationale: Inflammation drives atherogenesis. Animal and human studies have implicated interleukin (IL)-1β in this disease. Moderate hypoxia, a condition that prevails in the atherosclerotic plaque, may conspire with inflammation and contribute to the evolution and complications of atherosclerosis through mechanisms that remain incompletely understood. Objective: This study investigated the links ...
Choi Hye Jin HJ Laboratory of Mucosal Exposome and Biomodulation, Department of Biomedical Sciences, Pusan National University School of Medicine, Yangsan, South - - 2014
Carrageenan (CGN), a widely used food additive, has been shown to injure the epithelial barrier in animal models. This type of damage is a clinical feature of inflammatory bowel disease (IBD) in humans. In the present study, the effects of CGN on pro-apoptotic responses associated with macrophage inhibitory cytokine 1 ...
Tsai Ming-Kai MK Division of Nephrology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, - - 2014
Chemokines play essential roles during inflammatory responses and in pathogenesis of inflammatory diseases. Monocyte chemotactic protein-1 (MCP-1) is a critical chemokine in the development of atherosclerosis and acute cardiovascular syndromes. MCP-1, by its chemotactic activity, causes diapedesis of monocytes from the lumen to the subendothelial space that leads to atherosclerotic ...
Rumbo Carlos C Department of Microbiology, Complejo Hospitalario Universitario A Coruña-INIBIC, La Coruña, - - 2014
Acinetobacter baumannii is an extracellular opportunistic human pathogen that is becoming increasingly problematic in hospitals. In the present study, we demonstrated that the A. baumannii Omp33-36 KDa protein (Omp33-36) is a porin that acts as a channel for the passage of water. The protein is found on the cell surface ...
Baldwin William M WM 3rd aDepartment of Immunology, Lerner Research Institute, Cleveland Clinic bSchool of Health Sciences, Cleveland State University, Cleveland, Ohio, - - 2014
Experimental models have contributed enormously to basic immunology. However, the use of reductionist experiments has produced results that are not always successfully translated into the clinic. Recently, incorporation of more realistic clinical parameters in experimental designs has produced new insights relevant to cardiac transplantation. Experiments in mice have provided crucial ...
He Ping-Ping PP Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China; School of Nursing, University of South China, Hengyang, Hunan 421001, - - 2014
Accumulating evidence suggests that microRNA-590 (miR-590) has protective effects on cardiovascular diseases, but the mechanism is unknown. Interestingly, previous studies from our laboratory and others have shown that macrophage-derived lipoprotein lipase (LPL) might accelerate atherosclerosis by promoting lipid accumulation and inflammatory response. However, the regulation of LPL at the post-transcriptional ...
Wong Jacky J Centre for Cancer Research, Westmead Millennium Institute, University of Sydney, Westmead, - - 2014
The major regulators of human acute lymphoblastic leukemia (ALL) cell growth and survival mediate their effects through the phosphoinositide 3-kinase (PI-3K)/mammalian target of rapamycin (mTOR) pathway. We have shown that the mTOR inhibitor everolimus extended survival in a non-obese diabetic/severe combined immune-deficient (NOD/SCID) mouse xenograft model of human ALL. Since ...
Keightley Maria-Cristina MC Australian Regenerative Medicine Institute, Monash University, Clayton 3800, Victoria, Australia. Electronic address: - - 2014
The outcome following injury can be healing, repair or regeneration, all of which initiate within a resolving inflammatory response. Regeneration, comprising the complete anatomical and functional restoration of lost tissue with minimal residual consequence of injury, is the outcome that most holistically restores prior function. Leukocytes are recognized as playing ...
Wei Yi Y Icahn School of Medicine at Mount Sinai (Y.W., P.A.A.), New York, - - 2014
The purpose of this article is to review the evidence for the hypothesis that the core mechanism of dry eye disease (DED) is inflammation, including evidence from recent basic, clinical, and translational research involving human patients, animal models, and cell cultures. Using the key words "dry eye + inflammation," the ...
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