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Miot Charline C Université d'Angers, Angers, France Inserm, Unité 892, Angers, France CNRS, Unité 6299, Angers, France Laboratoire d'Immunologie et Allergologie, CHU Angers, Angers, - - 2014
Interleukin-26 (IL-26) is a member of the IL-10 cytokine family, first discovered based on its peculiar expression by virus-transformed T cells. IL-26 is overexpressed in chronic inflammation (rheumatoid arthritis and Crohn's disease) and induces proinflammatory cytokines by myeloid cells and some epithelial cells. We thus investigated the expression and potential ...
Vannella Kevin M KM Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of - - 2014
Mice expressing a Cre recombinase from the lysozyme M-encoding locus (Lyz2) have been widely used to dissect gene function in macrophages and neutrophils. Here, we show that while naïve resident tissue macrophages from IL-4Rαflox/deltaLysMCre mice almost completely lose IL-4Rα function, a large fraction of macrophages elicited by sterile inflammatory stimuli, ...
Zhu Xi-Chen XC Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, - - 2014
Accumulating evidence suggests that chronic metformin preconditioning offers potent neuroprotective effects against ischemic stroke. However, the underlying mechanisms remain largely unknown. In this study, we tested the hypothesis that chronic preconditioning with metformin conferred neuroprotection via suppression of nuclear factor kappa B (NF-κB)-mediated inflammatory pathway. Male Sprague-Dawley rats were treated ...
Elizabeth K E KE Department of Pediatrics, SAT Hospital, Government Medical College, Thiruvananthapuram, Kerala, India. Correspondence to: Dr KE Elizabeth, Professor of Pediatrics and Superintendent, SAT Hospital, Government Medical College, Thiruvananthapuram, Kerala, India 695 011. - - 2014
Immune Reconstitution Inflammatory Syndrome (IRIS), an exaggerated inflammatory response with clinical worsening due to immune recovery during treatment, is rare in the immune-competent population. A 5-½-year old immune-competent girl with CNS tuberculosis without HIV who developed paradoxical IRIS. Response to supportive care along with Anti-tuberculosis treatment. IRIS can occur in ...
Liu Zhi-Ming ZM Renmin Hospital of Wuhan University, Wuhan, 430060, China, - - 2014
In temporomandibular disorders (TMD), pain takes place when neuropeptides stimulate synovial tissue to produce several cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α, which activate neurons and glia of synovial membrane at the bilaminar regions of temporomandibular joint (TMJ). It has been reported that, after neurogenic differentiation, ...
Catrina Anca I AI Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm S-17176, - - 2014
Rheumatoid arthritis (RA) is a prototype for a criterion-defined inflammatory disease, for which the aetiology and initial molecular pathogenesis has been elusive for a long time. We describe in this Review how studies on the interplay between specific immunity, alongside genetic and environmental predisposing factors, provide new tools to understand ...
Silva Quinteiro Mariana M Laboratory of Orofacial Pain, Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, - - 2014
The aim of this study was to evaluate the peripheral effect of 15-deoxy(-Δ12,14)-Prostaglandin J2 (15d-PGJ2) in albumin-induced arthritis in temporomandibular joint (TMJ) of rats. Antigen-induced arthritis (AIA) was generated in rats with methylated bovine serum albumin (mBSA) diluted in complete Freund's adjuvant. Pretreatment with an intra-articular injection of 15d-PGJ2 (100ng/TMJ) ...
Kou Xiao-Xing XX Department of Orthodontics, 22 Zhongguancun Nandajie, Haidian District, Beijing 100081, PR China; Center for Craniofacial Stem Cell Research and Regeneration, 22 Zhongguancun Nandajie, Haidian District, Beijing 100081, PR - - 2014
Estrogen is involved in inflammation/pain of temporomandibular joint (TMJ), but the underlying mechanisms are largely unknown. Cadherin-11 plays an essential role in synovial inflammation. This study examined whether estrogen could potentiate cadherin-11 in synoviocytes and contribute to TMJ inflammatory pain. Female rats were ovariectomized, treated with increasing doses of 17β-estradiol ...
Pineda Miguel A MA Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 - - 2014
Objective. The parasitic worm-derived immunomodulator, ES-62 protects against disease in the mouse collagen-induced arthritis (CIA) model of Rheumatoid Arthritis (RA) by suppressing pathogenic IL-17 responses. The Th17-associated cytokine, IL-22 also appears to play a pathogenic role in autoimmune arthritis, particularly in promoting pro-inflammatory responses by synovial fibroblasts (SF) and osteoclastogenesis. ...
Sheth Tejas T *Department of Internal Medicine, St Peter's University Hospital, Drexel University College of Medicine ‡Department of Medicine, New York Medical College, Valhalla, NY †Rutgers-Robert Wood Johnson Medical School and University Hospital §Department of Medicine, Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School ∥Division of Gastroenterology and Hepatology, Rutgers-Robert Wood Johnson Medical School and University Hospital ¶Crohn's and Colitis Center of NJ, Rutgers-Robert Wood Johnson University Hospital, New Brunswick, - - 2014
Inflammatory bowel diseases are chronic inflammatory disorders of multiple organ systems, primarily involving the gut, with chronic relapsing and remitting course. Musculoskeletal involvement is the most common extraintestinal manifestation. Distinct cell-mediated and humoral immunopathophysiological mechanisms have been identified underlying gut and joint inflammation in patients with inflammatory bowel disease and ...
Yang Xiao X Department of Orthopedics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Sichuan, - - 2014
Microwave diathermy is a recommended physicotherapeutics commonly for the cases in treating inflammatory arthritis and improving the post-operative complications, which could help the synovial's fluid of the joints recover to being physiological status. Sialylation of the components especially on the glycan proteins and cell surface in the synovial fluid plays ...
Duan Juanli J Key Laboratory of Ministry of Education for Developmental Genes & Human Diseases, School of Life Sciences, Southeast University, Nanjing, - - 2014
Aims: This study aimed to examine the efficacy of a nanocarrier (polyethyleneimine [PEI]-superparamagnetic iron oxide nanoparticle [SPIO]), composed of a core of iron oxide and a shell of PEI, in the systemic delivery of therapeutic siRNA to experimental arthritic joints. Materials & methods: PEI-SPIO/siRNA nanoparticles were synthesized and characterized in ...
Wojdasiewicz Piotr P 0000-0003-3309-996X Department of General and Experimental Pathology, Second Faculty of Medicine, Medical University of Warsaw, Pawińskiego 3c, 02-106 Warsaw, - - 2014
Osteoarthritis (OA) is the most common chronic disease of human joints. The basis of pathologic changes involves all the tissues forming the joint; already, at an early stage, it has the nature of inflammation with varying degrees of severity. An analysis of the complex relationships indicates that the processes taking ...
Yoshida Kohsuke K Faculty of Health Sciences, Kobe University School of Medicine, Kobe 654-0142, - - 2014
Among the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects the circadian nature of disease manifestation. In addition, inflammatory cytokines, which reach peak secretion early in the morning are major players ...
Ranatunga Sriya S Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, - - 2014
The axial spondyloarthropathies are a group of chronic inflammatory diseases that predominantly affect the axial joints. This group includes ankylosing spondylitis and nonradiographic axial spondyloarthropathy. While the pathogenesis of axial spondyloarthropathies is not clear, immunologically active tissues primarily include the entheses, ie, the areas where ligaments, tendons, and joint capsules ...
Singh Animesh A 0000-0002-4296-5105 Department of Rheumatology, Charing Cross Hospital, Imperial College NHS Trust, London W6 8RF, - - 2014
Inflammatory arthritis is a condition which is characterised by recurrent episodes of joint pain and swelling. It encompasses a spectrum of disorders ranging from rheumatoid arthritis to ankylosing spondylitis. In these conditions, for reasons that are poorly understood, the immune system raises an inflammatory response within the joint space. In ...
Gu Shuping S Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, United States of - - 2014
The central importance of BMP signaling in the development and homeostasis of synovial joint of appendicular skeleton has been well documented, but its role in the development of temporomandibular joint (TMJ), also classified as a synovial joint, remains completely unknown. In this study, we investigated the function of BMPRIA mediated ...
Nita Małgorzata M Domestic and Specialized Medicine Centre "Dilmed", Bohaterów Monte Cassino 3, 40-231 Katowice, - - 2014
The products of oxidative stress trigger chronic low-grade inflammation (pathophysiological parainflammation) process in AMD patients. In early AMD, soft drusen contain many mediators of chronic low-grade inflammation such as C-reactive protein, adducts of the carboxyethylpyrrole protein, immunoglobulins, and acute phase molecules, as well as the complement-related proteins C3a, C5a, C5, ...
Schaible Hans-Georg HG Institute of Physiology 1/Neurophysiology, Jena University Hospital, Friedrich Schiller University of Jena, Teichgraben 8, 07743 Jena, - - 2013
Joints are densely innervated by postganglionic sympathetic nerve fibers. These fibers control the blood flow in the joint and vascular permeability, either directly or indirectly, in cooperation with leukocytes. Chemical sympathectomy or suppression of adrenergic signaling significantly reduces inflammatory processes in the initial acute state of inflammation whereas the same ...
Marijnissen Renoud J RJ Radboud University Nijmegen Medical Centre, Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Nijmegen, the - - 2013
Objective: The cytokine IL-21 can have both proinflammatory and immunosuppressive effects. Purpose of this study was to investigate the potential dual role of IL-21 in experimental arthritis in relation to Th17-cells. Method: In IL-21R-deficient mice and wild-types, antigen-induced arthritis (AIA) and chronic Streptococcal Cell Wall (SCW) arthritis were induced. Knee ...
Zhang Lei - - 2013
Myeloid-derived suppressor cells (MDSCs) have been reported to participate in immune suppression and autoimmune disorders. However, its role in autoimmune arthritis remains to be determined. We explored whether adoptive transfer of MDSCs in vivo would block joint inflammation and histological damage using collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA) models. ...
Carrión Mar - - 2013
Rheumatoid arthritis (RA) and osteoarthritis are two rheumatic diseases whose progression is associated with a chronic synovitis. Fibroblast-like synoviocytes (FLS) have been shown to play a pivotal role in initiating and perpetuating inflammatory and destructive processes in the rheumatoid joint. Recently, the stimulating role of IL-22 has been reported on ...
Dos Santos Solange Almeida - - 2013
Synovial membrane inflammation plays an important role in osteoarthritis (OA) pathophysiology. The synovial tissue of patients with initial OA is characterized by mononuclear cell infiltration and the production of pro-inflammatory cytokines and other mediators of joint injury. The study aims to evaluate the effect of low-level laser therapy (LLLT) at ...
Teunis T - - 2013
To identify the mediator profile in healthy, pre-osteoarthritis (OA) and end-stage OA radiocarpal joints. We hypothesized that there would be an increase in soluble mediators in posttraumatic wrist OA. We obtained radiocarpal synovial fluid samples from 3 groups of patients: healthy control (n = 12) samples were collected during wrist ...
de Alcântara Camejo Flavio - - 2013
BACKGROUND: Apoptosis is a programme of cell death which does not induce an inflammatory response. Recent previous research has suggested a correlation between temporomandibular internal derangement and apoptosis. Fas ligand (FasL) is an apoptosis-inducing factor, known to trigger apoptosis through distinct signal pathways. This study aims to examine, by immunohistochemistry, ...
Zhao Xu-Ying - - 2013
We have recently reported that CD4(+) T cells synthesize and secrete catecholamines that facilitate a shift of T helper 1 (Th1)/Th2 balance toward Th2 polarization. In this study, we used an animal model of human rheumatoid arthritis, collagen type II-induced arthritis (CIA), to explore relationship between catecholamine production in CD4(+) ...
Sokolove Jeremy - - 2013
Osteoarthritis (OA) has traditionally been classified as a noninflammatory arthritis; however, the dichotomy between inflammatory and degenerative arthritis is becoming less clear with the recognition of a plethora of ongoing immune processes within the OA joint and synovium. Synovitis is defined as inflammation of the synovial membrane and is characteristic ...
van den Brand B T BT Radboud University Nijmegen Medical Centre, Nijmegen, The - - 2013
Hyperactivation of innate immunity by Toll-like receptors (TLRs) can contribute to the development of autoinflammatory or autoimmune diseases. This study evaluated the activation of Tyro3, Axl, Mer (TAM) receptors, physiologic negative regulators of TLRs, by their agonists, growth arrest-specific protein 6 (GAS-6) and protein S, in the prevention of collagen-induced ...
Ammari Meryem - - 2013
PURPOSE OF REVIEW: It is becoming more and more obvious that epigenetic processes influence the development of rheumatic diseases as strongly as the genetic background. Research on the role of microRNAs (miRNAs) in rheumatic diseases, and especially in rheumatoid arthritis (RA), has been very active for the past 5 years. ...
MacFarlane Robert J - - 2013
Mesenchymal stem cells (MSCs) are multipotent stromal cells characterized by their ability to differentiate into adipocytes, chondrocytes, osteocytes and a number of other lineages. Investigation into their use has increased in recent years as characterization of their immunomodulatory properties has developed, and their role in the pathophysiology of joint disease ...
Galanti Concetta - - 2013
The temporomandibular joint (TMJ) connects the mandible to the skull. TMJ disorders induce degenerative tissue changes in TMJ disc that are largely the result of maladaption to abnormal joint loading. Histopathological studies have documented an association between TMJ arthropathy and loss of tissue cellularity, via apoptosis-related processes, that result in ...
Goodman Stuart B SB Department of Orthopaedic Surgery, Stanford University Medical Center, Redwood City, CA, - - 2013
Total joint arthroplasty has revolutionized the treatment of arthritic and degenerative conditions for many joints in the body; however, wear debris is continuously generated with day-to-day use of an artificial joint. Excessive production of wear by-products induces a foreign body and chronic inflammatory reaction that accelerates periprosthetic bone destruction and ...
Li Ning N Department of Rheumatology, Shanghai East Hospital, Tongji University, Shanghai, - - 2013
Rheumatoid arthritis (RA) is a common autoimmune disease of chronic systemic inflammatory disorder that will affect multiple tissues and organs such as skin, heart or lungs; but it principally attacks the joints, producing a nonsuppurative inflammatory and proliferative synovitis that often progresses to major damaging of articular cartilage and joint ...
Sadik Christian D CD Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, - - 2012
Neutrophil recruitment into the joint is a hallmark of inflammatory arthritides, including rheumatoid arthritis (RA). In a mouse model of autoantibody-induced inflammatory arthritis, neutrophils infiltrate the joint via multiple chemoattractant receptors, including the leukotriene B(4) (LTB(4)) receptor BLT1 and the chemokine receptors CCR1 and CXCR2. Once in the joint, neutrophils ...
Chaudhry Parvesh - - 2012
Prostate apoptosis response 4 (Par-4) is a ubiquitously expressed proapoptotic tumor suppressor protein. Here, we show for the first time, that Par-4 is a novel substrate of caspase-3 during apoptosis. We found that Par-4 is cleaved during cisplatin-induced apoptosis in human normal and cancer cell lines. Par-4 cleavage generates a ...
Erickson Michael - - 2012
Hyaluronan is a matrix polymer prominent in tissues undergoing rapid growth, development, and repair, in embryology and during malignant progression. It reaches 10(7) Daltons in size but also exists in fragmented forms with size-specific actions. It has intracellular forms whose functions are less well known. Hyaluronan occurs in all vertebrate ...
Chang Weiyuan - - 2011
Acetaminophen (APAP) is hepatotoxic and can cause toxicity in Jurkat T cells. p-Aminophenol (PAP), an industrial chemical and APAP metabolite, is nephrotoxic and hepatotoxic. Its potential toxicity in Jurkat T cells was investigated. PAP (10-250 µM) caused toxicity (decreased survival and increased LDH activity in incubation medium) and GSH depletion. ...
Chen Yongwen - - 2011
The expression and function of B7-H4, a recently identified co-inhibitory molecule of the B7 superfamily, in the pathogenesis of primary biliary cirrhosis (PBC) is still unclear. Here the expression of B7-H4 in sections from PBC patients (n = 16) was examined by immunohistochemistry and it was detected in primary bile duct epithelial ...
Canbakan Billur - - 2011
A letter in response to: Yilmaz Y, Kurt R, Kalayci C. Apoptosis in nonalcoholic steatohepatitis with normal aminotransferase values: zooming in on cytokeratin 18 fragments. Biomarkers Med. 4(5), 743-745 (2010).
Nakamura Yoshikuni - - 2011
The peroxisome proliferator-activated receptor (PPAR) δ is involved in tissue repair. In this study, we investigated the functional role of PPARδ in corneal epithelial wound healing. In an in vivo corneal wound-healing model, the changes of PPARδ expression in corneal epithelia were examined by immunofluorescence microscopy, and the effect of ...
Wong Yau Hsiung - - 2012
Leea indica is a medicinal plant traditionally used to treat cancer. Through bioassay-guided approach, we isolated mollic acid arabinoside (MAA), for the first time from Leea indica. Here, we present the apoptosis-inducing effect of MAA on Ca Ski cervical cancer cells. Based on DAPI staining, MAA-treated cells manifested nuclear shrinkage, ...
Jang Young Hoon - - 2011
Phospholipase D plays an anti-apoptotic role but little is known about dynamics of phospholipase D turnover during apoptosis. We have recently identified phospholipase D1 as a new substrate of caspases which generates the N-terminal and C-terminal fragment of phospholipase D1. In the present study, we tried to investigate whether association ...
Longtine Mark S - - 2011
Human placental villi are surfaced by a multinucleated and terminally differentiated epithelium, the syncytiotrophoblast, with a subjacent layer of mononucleated cytotrophoblasts that can divide and fuse to replenish the syncytiotrophoblast. The objectives of this study were (i) to develop an approach to definitively identify and distinguish cytotrophoblasts from the syncytiotrophoblast, ...
Boubaker J - - 2011
Objective:  Fractionation of ethyl acetate extract (EA) obtained from Nitraria retusa leaves was assessed using different methods of chromatography, and isorhamnetin3-O-rutinoside (I3-O-R) was isolated from this extract. Its structure was determined using data obtained from (1) H and (13) C NMR spectra, as well as by various correlation experiments (COSY, ...
Guery Leslie - - 2011
M-CSF-driven differentiation of peripheral blood monocytes is one of the sources of tissue macrophages. In humans and mice, the differentiation process involves the activation of caspases that cleave a limited number of proteins. One of these proteins is nucleophosmin (NPM1), a multifunctional and ubiquitous protein. Here, we show that caspases ...
Weinstein Robert S - - 2011
The adverse skeletal effects of glucocorticoid excess are due to increased osteoclast survival, decreased production of osteoblasts, and increased apoptosis of osteoblasts and osteocytes, but it remains unknown which of these is the principle cause of the decrease in bone strength. Previous studies suggested that osteocytes contribute to bone strength ...
Liang Jiurong J Division of Pulmonary, Allergy and Critical Care Medicine, Duke University School of Medicine, Durham, NC, - - 2011
The characteristics of human asthma are chronic inflammation and airway remodeling. Hyaluronan, a major extracellular matrix component, accumulates during inflammatory lung diseases, including asthma. Hyaluronan fragments stimulate macrophages to produce inflammatory cytokines. We hypothesized that hyaluronan and its receptors would play a role in human asthma. To investigate the role ...
Gaylord Monica L - - 2011
Tree defense against bark beetles (Curculionidae: Scolytinae) and their associated fungi generally comprises some combination of constitutive (primary) and induced (secondary) defenses. In pines, the primary constitutive defense against bark beetles consists of preformed resin stored in resin ducts. Induced defenses at the wound site (point of beetle entry) in ...
Gasparoto Thaís H - - 2011
Gerodontology 2011; doi: 10.1111/j.1741-2358.2011.00476.x Salivary immunity in elderly individuals presented with Candida-related denture stomatitis Objectives:  Elderly individuals with Candida-related denture stomatitis (DS) present with a reduced defence against Candida albicans. This study evaluated levels of antimicrobial mediators in the elderly DS saliva and salivary neutrophils' activation characteristics compared with elderly ...
McNally Sara - - 2011
Abstract The pubertal mammary gland is an ideal model for experimental morphogenesis. The primary glandular branching morphogenesis occurs at this time, integrating epithelial cell proliferation, differentiation, and apoptosis. Between birth and puberty, the mammary gland exists in a relatively quiescent state. At the onset of puberty, rapid expansion of a ...
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