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Birbrair Alexander - - 2015
Perivascular multipotent cells, pericytes, contribute to the generation and repair of various tissues in response to injury. They are heterogeneous in their morphology, distribution, origin and markers, and elucidating their molecular and cellular differences may inform novel treatments for disorders in which tissue regeneration is either impaired or excessive. Moreover, ...
Choudhary Gaurav S GS Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave. NB40, Cleveland, OH, 44195, - - 2015
Apoptosis can be measured by number of methods by taking advantage of the morphological, biochemical, and molecular changes undergoing in a cell during this process. The best recognized biochemical hallmark of both early and late stages of apoptosis is the activation of cysteine proteases (caspases). Detection of active caspase-3 in ...
Parlato Marianna M Unit of Cytokines and Inflammation, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris Cedex 15, - - 2015
Critically ill patients who display a systemic inflammatory response syndrome (SIRS) are prone to develop nosocomial infections. The challenge remains to distinguish as early as possible among SIRS patients those who are developing sepsis. Following a sterile insult, damage-associated molecular patterns (DAMPs) released by damaged tissues and necrotic cells initiate ...
Gautier Emmanuel L EL Institut National de la Sante et de la Recherche Médicale UMR_S 1166, Paris, France; Pierre & Marie Curie University Paris 6, Paris, France; ICAN Institute of CArdiometabolism & Nutrition, Paris, - - 2014
Macrophages are phagocytes characterized by high lysosomal activity and are involved in a wide range of biological processes. Consequently, macrophages have long been recognized for their critical roles in development as well as in healthy and pathological states. Our knowledge about macrophage biology has evolved greatly over the past several ...
Linkermann Andreas A Clinic for Nephrology and Hypertension, Christian-Albrechts-University, 24105 Kiel, - - 2014
Regulated cell death (RCD) is either immunologically silent or immunogenic. RCD in parenchymal cells may lead to the release of damage- associated molecular patterns that drive both tissue inflammation and the activation of further pathways of RCD. Following an initial event of regulated necrosis, RCD and inflammation can induce each ...
Stone Joshua K JK Department of Microbiology and Immunology, University of South Alabama, 610 Clinic Drive, Mobile, AL 36688, - - 2014
Burkholderia pseudomallei is a gram-negative bacterium that causes melioidosis, a multifaceted disease that is highly endemic in southeast Asia and northern Australia. This facultative intracellular pathogen possesses a large genome that encodes a wide array of virulence factors that promote survival in vivo by manipulating host cell processes and disarming ...
Rossin A A Université de Nice, Institut de Biologie Valrose, CNRS UMR 7277, INSERM UMR 1091, Nice, - - 2014
The death receptor Fas undergoes a variety of post-translational modifications including S-palmitoylation. This protein acylation has been reported essential for an optimal cell death signaling by allowing both a proper Fas localization in cholesterol and sphingolipid-enriched membrane nanodomains, as well as Fas high-molecular weight complexes. In human, S-palmitoylation is controlled ...
Griebel Thomas T Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, - - 2014
Intracellular nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are basic elements of innate immunity in plants and animals. Whereas animal NLRs react to conserved microbe- or damage-associated molecular patterns, plant NLRs intercept the actions of diverse pathogen virulence factors (effectors). In this review, we discuss recent genetic and molecular evidence for ...
Zhang Feng F Key Laboratory of Environment and Gene Related Diseases of Ministry Education, School of Public Health, College of Medicine, Xi'an Jiaotong University, Xi'an, PR - - 2014
Kashin-Beck disease (KBD) is a serious osteoarthropathia, mainly characterized by excessive chondrocyte necrosis and apoptosis. The molecular signaling pathways underlying KBD excessive chondrocyte apoptosis remain unclear, leading to a lack of effective medical interventions now. To clarify whether expression quantitative trait loci (eQTLs) contribute to excessive chondrocyte apoptosis of Kashin-Beck ...
Manresa Mario C MC University College - - 2014
Tissue injury can occur for a variety of reasons including physical damage, infection and ischemia. The ability of tissues to effectively recover from injury is a cornerstone of human health. The healing response in tissues is conserved across organs and typically involves distinct but overlapping inflammatory, proliferative and maturation/resolution phases. ...
Nishida Kazuhiko K Cardiovascular Division, King's College London British Heart Foundation Centre of Excellence, London SE5 9NU, - - 2014
Autophagy has evolved as a conserved process for bulk degradation and recycling of cytoplasmic components, such as long-lived proteins and organelles. Macroautophagy is the most prevalent form and thus referred to as autophagy. Autophagy is initially considered to be a non-selective process as an adaptive response to nutrient starvation. However, ...
Wang Qian Q Central Laboratory, Wuxi People's Hospital of Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, Jiangsu, People's Republic of - - 2014
Multidrug resistance (MDR) to chemotherapeutic agents is a major obstacle to curative treatment of cancer. In various types of cancers, overexpression of glucosylceramide synthase (GCS) has been observed to be associated with MDR, thus making GCS a target for reversal of resistance. Our previous work demonstrated that GCS and Bcl-2 ...
Caldwell Andrew B AB Signaling Systems Laboratory, Department of Chemistry and Biochemistry, and San Diego Center for Systems Biology, University of California at San Diego, La Jolla, California 92093, - - 2014
A hallmark of the inflammatory response to pathogen exposure is the production of tumor necrosis factor (TNF) that coordinates innate and adaptive immune responses by functioning in an autocrine or paracrine manner. Numerous molecular mechanisms contributing to TNF production have been identified, but how they function together in macrophages remains ...
Boland Sonja S Univ Paris Diderot, (Sorbonne Paris Cité), UMR 8251 CNRS, Unit of Functional and Adaptive Biology (BFA), Laboratory of Molecular and Cellular Responses to Xenobiotics (RMCX), Paris, - - 2014
Increasing evidence link nanomaterials with adverse biological outcomes and due to the variety of applications and potential human exposures to nanoparticles, it is thus important to evaluate their toxicity for the risk assessment of workers and consumers. It is crucial to understand the underlying mechanisms of their toxicity as observation ...
Nikitovic Dragana D Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete, Heraklion, Greece. Electronic address: - - 2014
Interleukin-18 (IL-18) has been shown to play a key proximal role in the induction of allergic contact dermatitis. Low molecular weight hyaluronan (LMWHA), an endogenous molecule and a member of the so-called damage associated molecular patterns (DAMPs), has been suggested to elicit immune-stimulatory effects. The purpose of this study was ...
Farha Arakkaveettil Kabeer AK Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India, - - 2014
Deoxyelephantopin, a sesquiterpene lactone extracted and purified from Elephantopus scaber, has been shown to exhibit antitumor and hepatoprotective activities. The purpose of this study was to investigate the antiproliferative and apoptosis-inducing properties of deoxyelephantopin in SiHa cells and to elucidate the underlying molecular mechanisms. Deoxyelephantopin inhibited growth of SiHa cells ...
Kabátková Markéta M Department of Cytokinetics, Institute of Biophysics AS CR, Královopolská 135, 61265 Brno, Czech Republic; Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlářská 2, 61137 Brno, Czech - - 2014
Polycyclic aromatic hydrocarbons (PAHs) with lower molecular weight exhibit lesser genotoxicity and carcinogenicity than highly carcinogenic PAHs with a higher number of benzene rings. Nevertheless, they elicit specific effects linked with tumor promotion, such as acute inhibition of gap junctional intercellular communication (GJIC). Although inflammatory reaction may alter bioactivation and ...
Santos Cécile C SPCMIB, UMR-CNRS 5068-Université Paul Sabatier-Toulouse III, 118, route de Narbonne, F-31062 Toulouse Cedex 9 - - 2014
A highly compartmentalized enzymatic network regulates the pro-apoptotic and proliferative effects of sphingolipids. Over-conversion of ceramide (Cer) correlates with insensitivity to apoptosis signaling (in response to chemotherapy) and to drug resistance of cancer cells. De novo sphingomyelin biosynthesis relies on non-vesicular ceramide trafficking by the CERT (CERamide Transfer) protein. Therefore, ...
Adanitsch Florian F Department of Chemistry, University of Natural Resources and Life Sciences , Muthgasse 18, A-1190 Vienna, - - 2014
The endotoxic portion of lipopolysaccharide (LPS), a glycophospholipid Lipid A, initiates the activation of the Toll-like Receptor 4 (TLR4)-myeloid differentiation factor 2 (MD-2) complex, which results in pro-inflammatory immune signaling. To unveil the structural requirements for TLR4·MD-2-specific ligands, we have developed conformationally restricted Lipid A mimetics wherein the flexible βGlcN(1→6)GlcN ...
Won Haejung H Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United - - 2014
The mechanisms controlling the development of dendritic cells (DCs) remain incompletely understood. Using an Mysm1 knockout (Mysm1(-/-)) mouse model, we identified the histone H2A deubiquitinase Mysm1 as a critical regulator in DC differentiation. Mysm1(-/-) mice showed a global reduction of DCs in lymphoid organs whereas development of granulocytes and macrophages ...
Lee Su Jin SJ Department of Nuclear Medicine, Ajou University School of Medicine, Suwon, Korea; - - 2014
For (18)F-FDG PET to be widely used to monitor atherosclerosis progression and therapeutic response, it is crucial to better understand how macrophage glucose metabolism is influenced by the atherosclerotic microenvironment and to elucidate the molecular mechanisms of this response. Oxidized low-density lipoprotein (oxLDL) is a key player in atherosclerotic inflammation ...
Meng Lan-Zhen LZ a State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences , University of Macau , Macao SAR , - - 2014
Two Ganoderma species, G. lucidum and G. sinense, are listed as Lingzhi in Chinese Pharmacopoeia and they are considered to have the same therapeutic effects. Polysaccharides were the main immunomodulatory and anticancer components in Ganoderma. In this study, the chemical characters and the effects of polysaccharides from G. lucidum (GLPS) ...
Wooden Jessica J Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center 985800 Nebraska Medical Center, Omaha, Nebraska - - 2014
The importance of Chromatin Immunoprecipitation (ChIP) technology has grown exponentially along with an increased interest in epigenetic regulation. The correlation of transcription factors with histone marks is now well established as the center of epigenetic studies; therefore, precise knowledge about histone marks is critical to unravel their molecular function and ...
Ehashi Tomo T Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, - - 2014
Biomaterials that contact with soft tissues such as postoperative adhesion prevention membrane or tissue-regenerative scaffolds should possess specific features such as hydrophilicity, mild to no immunogenicity, and quick degradability. The inflammation reaction to multiblock copolymers of poly(L-lactic acid) (PLLA) and poly(ethylene glycol), named as Multi, which we developed as a ...
Ji Yi Y Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, 610041, - - 2014
Currently, propranolol is the preferred treatment for problematic proliferating infantile hemangiomas (IHs). The rapid action of propranolol has been shown to be especially dramatic in IHs involving dyspnea, hemodynamic compromise, palpebral occlusion, or ulceration. Another remarkable aspect of propranolol treatment that was revealed was that not only was the growth ...
Castelino Flavia V FV aDivision of Rheumatology, Massachusetts General Hospital, Boston, MA bDivision of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, - - 2014
To summarize the recent advances in understanding the novel cytokine pathways, intracellular signaling molecules, cell-fate decisions, cellular aging and senescence, and the cross-talk of effector cells and the extracellular matrix (ECM) in the pathogenesis of systemic sclerosis (SSc) fibrosis. Studies from the animal models and human beings implicate novel molecular ...
de Bruin Alexander M AM Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, - - 2014
The pro-inflammatory cytokine interferon-gamma (IFNγ) is well-known for its important role in innate and adaptive immunity against intracellular infections and for tumor control. Yet, it has become clear that IFNγ also has a strong impact on bone marrow (BM) output during inflammation, as it affects the differentiation of most hematopoietic ...
Schjenken Je J School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, SA, - - 2014
Seminal fluid delivered to the female reproductive tract at coitus not only promotes the survival and fertilizing capacity of spermatozoa, but also contains potent signalling agents that influence female reproductive physiology to improve the chances of conception and reproductive success. Male to female seminal fluid signalling occurs in rodents, domestic ...
Niimori Daisuke D Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, - - 2014
During the wound-healing process, macrophages, fibroblasts, and myofibroblasts play a leading role in shifting from the inflammation phase to the proliferation phase, although little is known about the cell differentiation and molecular control mechanisms underlying these processes. Previously, we reported that Tsukushi (TSK), a member of the small leucine-rich repeat ...
Häcker Georg G Institute for Medical Microbiology and Hygiene, University Medical Centre Freiburg, Hermann Herder-Str. 11, D-79104 Freiburg, Germany. Electronic address: - - 2014
During ER-stress, one of the responses a cell can choose is apoptosis. Apoptosis generally is a cell's preferred response when other control mechanisms are overwhelmed. We now have a reasonably clear molecular picture what is happening once the apoptotic apparatus has been started. Unclear however are the majority of the ...
Morciano Giampaolo G Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, - - 2014
The mitochondrial permeability transition is a key event in cell death. Intense research efforts have been focused on elucidating the molecular components of the mitochondrial permeability transition pore (mPTP) to improve the understanding and treatment of various pathologies, including neurodegenerative disorders, cancer and cardiac diseases. Several molecular factors have been ...
Dalbeth Nicola N Department of Medicine, University of Auckland, Auckland, New Zealand. Electronic address: - - 2014
The aims of this article were to systematically review the literature about the mechanism of action of colchicine in the multimodal pathology of acute inflammation associated with gout and to consider the clinical utility of colchicine in other chronic inflammatory diseases. The English-language literature on PubMed was searched for articles ...
Bernasconi Eric E Service of Gastroenterology and Hepatology, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, - - 2014
Objective: Macrophages play a critical role in intestinal wound repair. However, the molecular pathways that regulate macrophage wound repair activities remain poorly understood. The aim of this study was to evaluate the role of GM-CSF receptor signaling in the wound repair activities of macrophages. Methods: Murine macrophages were differentiated from ...
Kang Hyunju H Targeted Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, Chungbuk, Republic of Korea. College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea. These authors contributed equally to this - - 2014
Lytic induction of latent Kaposi's sarcoma-associated herpesvirus (KSHV) has been considered as a therapeutic option for efficient treatment of several KSHV-associated malignancies. Here, we developed a robust high-throughput screening system that allows an easy and quantitative measurement of lytic induction of latent KSHV and discovered three anthracyclines as potent inducers ...
Wajant Harald - - 2014
Abstract CD95 (Apo1/Fas) has been originally identified as the target of cell death-inducing antibodies. The recognition of CD95 as an apoptosis-triggering receptor represents one of the early milestones in the apoptosis field. Moreover, the research on CD95-induced cell death fostered various other discoveries of broad and general relevance in cell ...
Jiang Youde Y Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, United - - 2014
Ocular trauma affects 20% of Americans in their lifetime and can cause permanent visual system damage. We have used a mouse model of ocular trauma (exposure to an air blast from a paintball gun) to examine pathways that trigger the resulting retinal damage and to develop treatment strategies that might ...
Hazeldine Jon J NIHR Surgical Reconstruction and Microbiology Research Centre, Centre for Translational Inflammation Research, School of Immunity and Infection, Birmingham University Medical School, Birmingham B15 2TT, UK. Electronic address: - - 2014
A well described consequence of traumatic injury is immune dysregulation, where an initial increase in immune activity is followed by a period of immune depression, the latter leaving hospitalised trauma patients at an increased risk of nosocomial infections. Here, we discuss the emerging role of the neutrophil, the most abundant ...
Zhang Yong Y *Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania †Department of General Surgery, Union Hospital, Huazhong University of Science and Technology, China ‡This author contributed equally to this work and should be considered co-first - - 2014
An excessive and uncontrolled systemic inflammatory response is associated with organ failure, immunodepression, and increased susceptibility to nosocomial infection following trauma. Interleukin-6 (IL-6) plays a particularly prominent role in the host immune response after trauma with hemorrhage. However, as a result of its pleiotropic functions, the effect of IL-6 in ...
Zhao Cong - - 2014
Historically, fever, pneumonia, and sepsis after trauma are ascribed to pain and poor pulmonary toilet. No evidence supports that assertion however, and no known biologic mechanisms link injury to infection. Our studies show that injured tissues release mitochondria (MT). Mitochondrial damage-associated molecular patterns (mtDAMPs) however can mimic bacterial pathogen-associated danger ...
Niesler Ulrike U *Department of Trauma Surgery, Hand, Plastic and Reconstructive Surgery and † Department of Anesthesiology and Intensive Care, Center for Biomedical Research, University of Ulm, Helmholtzstr. 8/2, 89081 Ulm, - - 2014
Acute lung injury (ALI) and its more severe form acute respiratory distress syndrome (ARDS) can result from both direct and indirect pulmonary damage caused by trauma and shock. In the course of ALI/ARDS, mediators released from resident cells, such as alveolar macrophages, may act as chemoattractants for invading cells and ...
Niesler Ulrike U From the Departments of Trauma Surgery, Hand, Plastic and Reconstructive Surgery (U.N., A.P., J.S.F., S.T.B., F.G., M.W.K., D.H.S.) and Clinical Chemistry (S.Z.), University of Ulm, Ulm, - - 2014
Blunt chest trauma is an injury that enhances the morbidity and mortality rate, particularly in the context of polytrauma. Our previous studies showed local and systemic inflammatory alterations after blunt chest trauma in mice. This study was designed to determine whether alveolar macrophages (AMΦ) have an alleviative role in this ...
Pierce Albert A Department of Anesthesiology, University of Alabama at Birmingham, Birmingham Alabama, - - 2014
Recent studies have changed our understanding of the timing and interactions of the inflammatory processes and coagulation cascade following severe trauma. This review highlights this information and correlates its impact on the current clinical approach for fluid resuscitation and treatment of coagulopathy for trauma patients. Severe trauma is associated with ...
Volpin Gershon G Department of Orthopaedic Surgery, Western Galilee Hospital, Naharia, Israel, - - 2014
Much research is now being conducted in order to understand the role of cytokines in the development of the inflammatory response following trauma. The purpose of this study was to evaluate whether serum levels of certain cytokines, measured immediately after initial injury, can be used as potential biomarkers for predicting ...
Rehman Yasir Y 0000-0002-2817-3638 Neuro Science, Division of Neurology, Department of Medicine, Mc Master University, Hamilton, ON, - - 2014
Besides brain injury and systemic infection, cognitive and concussion like sickness behaviour is associated with muscular trauma and perioperative patients, which represents a major obstacle to daily activities and rehabilitation. The neuroinflammatory response triggers glial activation and consequently the release of proinflammatory cytokines within the hippocampus. We review clinical studies ...
Seiter Maximilian A MA Department of Pediatrics I, Medical University Innsbruck, Anichstraße 35, A-6020 Innsbruck, Austria ; Tyrolean Cancer Research Institute, Innrain 66, A-6020 Innsbruck, - - 2014
Defects in the regulation of apoptosis are one main cause of cancer development and may result from overexpression of anti-apoptotic proteins such as the X-linked inhibitor of apoptosis protein (XIAP). XIAP is frequently overexpressed in human leukemia and prostate and breast tumors. Inhibition of apoptosis by XIAP is mainly coordinated ...
Soskic Blagoje B School of Immunity and Infection, University of Birmingham, Birmingham, United - - 2014
T cell activation is a key event in the adaptive immune response and vital to the generation of both cellular and humoral immunity. Activation is required not only for effective CD4 T cell responses but also to provide help for B cells and the generation of cytotoxic T cell responses. ...
Mazon Moya Maria J MJ Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College - - 2014
Shigella flexneri is an intracellular pathogen that can escape from phagosomes to reach the cytosol, and polymerize the host actin cytoskeleton to promote its motility and dissemination. New work has shown that proteins involved in actin-based motility are also linked to autophagy, an intracellular degradation process crucial for cell autonomous ...
Park Joo-In JI Department of Biochemistry, Dong-A University Busan, South - - 2014
Many marine triterpene glycosides have in vitro and in vivo activities with very low toxicity, suggesting that they are suitable agents for the prevention and treatment of different diseases, particularly cancer. However, the molecular mechanisms of action of natural marine compounds in cancer, immune, and other various cells are not ...
Kiedrowski Miroslaw M Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences - SGGW, Warsaw, Poland ; Department of Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, - - 2014
Like many malignancies, the development of colorectal carcinoma (CRC) can be considered as an imbalance between the compromised process of programmed cell death (apoptosis) and excessive, uncontrolled proliferation. Several mutations and epigenetic alterations are acquired during colorectal carcinogenesis. These are responsible for the cell cycle regulation, cellular sensitivity to pro- ...
McCracken Jenna M JM Inflammation Program, University of Iowa, Iowa City, IA, USA. ; Department of Microbiology, University of Iowa, Iowa City, IA, - - 2014
Neutrophils (also called polymorphonuclear leukocytes, PMNs) are the most abundant white blood cells in humans and play a central role in innate host defense. Another distinguishing feature of PMNs is their short lifespan. Specifically, these cells survive for less than 24 hours in the bloodstream and are inherently pre-programed to ...
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