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Wechalekar Mihir D MD Mihir D Wechalekar, Malcolm D Smith, Rheumatology Research Unit, Repatriation General Hospital, Daw Park SA 5041, - - 2014
The synovium is the soft tissue lining diarthrodial joints, tendon sheaths and bursae and is composed of intimal and subintimal layers. The intimal layer is composed of type A cells (macrophages) and type B cells (fibroblasts); in health, the subintima has few inflammatory cells. The synovium performs several homeostatic functions ...
Andersson K M E KM Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, University of Gothenburg, - - 2014
Survivin is a proto-oncogene that regulates cell division and apoptosis. It is a molecular marker of cancer. Recently, survivin has emerged as a feature of RA, associated with severe joint damage and poor treatment response. The present study examined if inhibition of survivin affects experimental arthritis, which was induced in ...
Misharin Alexander V AV Division of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, - - 2014
Different subsets and/or polarized phenotypes of monocytes and macrophages may play distinct roles during the development and resolution of inflammation. Here, we demonstrate in a murine model of rheumatoid arthritis that nonclassical Ly6C(-) monocytes are required for the initiation and progression of sterile joint inflammation. Moreover, nonclassical Ly6C(-) monocytes differentiate ...
Sieghart Daniela D Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster for Rheumatology, Balneology and Rehabilitation, Institute for Rheumatology and Balneology, Vienna-Oberlaa, - - 2014
Balneotherapy employing sulphurous thermal water is still applied to patients suffering from diseases of musculoskeletal system like osteoarthritis (OA) but evidence for its clinical effectiveness is scarce. Since the gasotransmitter hydrogen sulphide (H2 S) seems to affect cells involved in degenerative joint diseases, it was the objective of this study ...
Orlowsky Eric W - - 2014
Chondroitin Sulphate (CS), a natural glycosaminoglycan of the extracellular matrix, has clinical benefit in symptomatic osteoarthritis but has never been tested in gout. In vitro, CS has anti-inflammatory and positive effects on osteoarthritic chondrocytes, synoviocytes and subchondral bone osteoblasts, but its effect on macrophages is unknown. The purpose of our ...
Tsuchida Anika I - - 2014
IntroductionThis study aimed to evaluate whether profiles of several soluble mediators in synovial fluid and cartilage tissue are pathology-dependent and how their production is related to in vitro tissue formation by chondrocytes from diseased and healthy tissue.MethodsSamples were obtained from donors without joint pathology (n¿=¿39), with focal defects (n¿=¿65) and ...
An Ling-Ling LL Department of Respiratory, Inflammation and Autoimmune Diseases, MedImmune, LLC, Gaithersburg, MD, - - 2014
Anaphylatoxin C5a released upon complement activation is associated with both acute and chronic inflammations such as gout. The pathogenesis of gout was identified as uric acid crystals deposition in the joints that activates inflammasome, nod-like receptor pyrin domain-containing protein 3 (NLRP3), leading to IL-1β release. However, little is known about ...
Jackson Miriam T MT Raymond Purves Bone and Joint, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, Royal North Shore Hospital, St. Leonards, NSW, 2065, - - 2014
Objectives: To explore the involvement of protease activated receptor (PAR)-1 and PAR-2 in osteoarthritis (OA) joint pathology and the cells/tissues primarily affected by their ablation. Methods: Destabilisation of the medial meniscus (DMM)-induced OA in wild-type (WT), PAR-1(+/+) , PAR-1(-/-) and PAR-2(-/-) mice was compared by histologic scoring (cartilage aggrecan loss ...
Teunis Teun T Teun Teunis MD, Arnold H. Schuurman MD PhD, L. Paul van Minnen MD PhD, Department of Plastic Reconstructive and Hand Surgery University Medical Center, Utrecht, The - - 2014
New discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. We aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. Based on the general faster ...
Kaneva Magdalena K MK Faculty of Science and Technology, University of Westminster, 115 New Cavendish Street, London W1W 6UW, United Kingdom. Electronic address: - - 2014
Mechanical injury can greatly influence articular cartilage, propagating inflammation, cell injury and death-risk factors for the development of osteoarthritis. Melanocortin peptides and their receptors mediate anti-inflammatory and pro-resolving mechanisms in chondrocytes. This study aimed to investigate the potential chondroprotective properties of α-MSH and [DTRP(8)]-γ-MSH in mechanically injured cartilage explants, their ...
Chen Wei-Hong WH Stem Cell Research Center, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Biomedical Materials and Engineering, College of Oral, Medicine, Taipei Medical University, Taipei, - - 2014
Osteoarthritis (OA) is a common disease associated with tissue inflammation, physical disability and imbalanced homeostasis in cartilage. For advanced treatments, biological approaches are currently focused on tissue regeneration and anti-inflammation. This study was undertaken to evaluate the therapeutic efficacies of hyaluronic acid (HA) and platelet-rich plasma (PRP) (HA+PRP) on OA. ...
Wu Cuiyan C School of Public Health, Xi'an Jiaotong University Health Science Center; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education; Key Laboratory of Trace Elements and Endemic Diseases, Ministry of Health, Xi'an, Shaanxi, 710061, PR China. Electronic address: - - 2014
This study was undertaken to monitor autophagy in chondrocytes with Kashin-Beck disease (KBD) and osteoarthritis (OA). The identification and quantification of autophagy were morphologically visualized by transmission electron microscopy, together with immunohistochemical localization of Beclin1 and LC3 in cartilage, and immunoblotting of cellular Beclin1, LC3 and p62/SQSTM1 in the normal, ...
Luczkiewicz P P Department of Orthopedics, University Medical Center, ul. Smoluchowskiego 17, 80-214 Gdansk, - - 2014
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia and progressive joint destruction. Despite aggressive treatment with anti-rheumatic drugs, progressive destruction of joints continues to occur in RA patients, who subsequently require joint surgery. A lot of evidence suggest that fibroblast-like synovial cells (FLS) play crucial role ...
Liu Jingjing J Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212013, PR China; Department of Clinical Laboratory and Hematology, School of Medical Science and Laboratory Medicine of Jiangsu University, Zhenjiang, Jiangsu 212013, PR - - 2014
Our previous study has demonstrated that Toll-like receptor 4 (TLR4) can contribute to anti-β2-glycoprotein I/β2-glycoprotein I (anti-β2GPI/β2GPI)-induced tissue factor (TF) expression in human acute monocytic leukemia cell line THP-1. However, the role of TLR4 in the activation of autoimmune response in antiphospholipid syndrome (APS) has rarely been reported. In this ...
Zhao Ting T From the Department of Surgery (T.Z.), Division of Trauma, Emergency Surgery & Surgical Critical Care, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Department of Surgery (Y.L., B.L., I.H., H.B.A.), University of Michigan Hospital, Ann Arbor, Michigan; and Department of Microbiology and Immunobiology (R.T.B.), Harvard Medical School, Boston, - - 2014
We have recently demonstrated that inhibition of histone deacetylase (HDAC) Class I, II, and IV with nonspecific HDAC inhibitors improves survival in a mouse model of lethal cecal ligation and puncture (CLP). However, the consequence of HDAC Class III inhibition is unknown in this model. The aims of the present ...
Li Qingsheng Q Department of Hematology, The First Affiliated Hospital, Anhui Medical University , Hefei , PR China - - 2014
Abstract Immune thrombocytopenia (ITP) is an acquired autoimmune disorder. Both impaired platelet production and T-cell-mediated effects play a role in ITP. A T-helper1 (Th1) polarization of the immune response and up-regulation of Th17 cells have been demonstrated in ITP patients. Interleukin (IL)-12 and IL-23 produced by antigen presenting cells are ...
Pritz Theresa T Institute for Biomedical Aging Research, Universität Innsbruck, Rennweg 10, Innsbruck, - - 2014
With aging the immune system undergoes significant age-related changes. These age-dependent changes are referred to as immunosenescence and are partially responsible for the poor immune response to infections and the low efficacy of vaccination in elderly persons. Immunosenescence is characterized by a decrease in innate and adaptive cell-mediated immune function ...
Dobbs Nicole A NA Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX - - 2014
Mycoplasmas are a common cause of pneumonia in humans and animals, and attempts to create vaccines have not only failed to generate protective host responses, but they have exacerbated the disease. Mycoplasma pulmonis causes a chronic inflammatory lung disease resulting from a persistent infection, similar to other mycoplasma respiratory diseases. ...
Trebinska Alicja A Department of Molecular and Translational Oncology, Cancer Center Institute, Warsaw, - - 2014
HS-1-associated protein X-1 (HAX-1) is a multi-functional protein that has been implicated in the regulation of apoptosis, cell motility and calcium homeostasis. In the present study, we set out to assess the postulated functional resemblance of HAX-1 to the BCL-2 family of anti-apoptotic proteins using non-transformed, cytokine-dependent murine bone marrow ...
Bengtsson Anders A - - 2014
Polymorphonuclear leukocytes (PMN) are main effector cells in the acute immune response. While the specific role of PMN in systemic lupus erythematosus (SLE) and autoimmunity is still unclear, their importance in chronic inflammation is gaining more attention. Here we investigate aspects of function, bone marrow release and activation of PMN ...
Grailer Jamison J JJ Department of Pathology, University of Michigan Medical School, Ann Arbor, Mich., - - 2014
Sepsis, both in humans and in rodents, is associated with persistent immunosuppression accompanied by defects in innate immunity during the acute phase of sepsis. Mice were rendered septic by cecal ligation and puncture (CLP) followed by the induction of acute lung injury, employing distal airway deposition of IgG immune complexes, ...
Linehan Eimear E Centre for Infection and Immunity, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, Northern - - 2014
Aging results in deterioration of the immune system, which is associated with increased susceptibility to infection and impaired wound healing in the elderly. Phagocytosis is an essential process in both wound healing and immune defence. As such, age-related impairments in phagocytosis impact on the health of the elderly population. Phagocytic ...
de Cortie Karin - - 2014
Abstract Purpose: We recently demonstrated that endoglin, an ancillary transforming growth factor beta (TGF-β) receptor, modulates vascular damage and fibrosis formation and influences renal function after kidney irradiation. We also suggested that this was partially accomplished by endoglin-mediated regulation of cytokine production in macrophages. Endoglin is expressed on both endothelial ...
Murray Peter J PJ Departments of Infectious Diseases and Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: - - 2014
Ongoing monocyte infiltration and subsequent macrophage seeding of adipose tissue is thought to be a key feature of obesity pathophysiology. Nagareddy et al. (2014) show that adipose cells locally activate IL-1β in macrophages in part through the alarmin S100A8/A9, which stimulates bone marrow myelopoiesis to perpetuate nonresolving inflammation.
Li Hui-Yuan HY State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , Tianjin , People's Republic of - - 2014
Abstract Primary immune thrombocytopenia (ITP) is an autoimmune disease with many immune dysfunctions, including over-proliferation and apoptosis resistance of auto-reactive lymphocytes. This study aimed to determine the effects of interleukin (IL)-7 on the cytokine production and survival of peripheral blood mononuclear cells and bone marrow mononuclear cells from ITP patients. ...
Sun Li-Fei LF a Department of Tumor Research and Treatment Centricity , People's Liberation Army No. 148 Hospital , Zibo , Shandong Province , - - 2014
Abstract Eosinophils (EOS) quantity, active state, peroxidase activity (POX) and HLA-DR expression in bone marrow of 176 Auto-Immune-Related Hematocytopenia (AIRH) patients were analyzed. Immunofluorescent staining (IF) is performed to observe the expression of immunizing molecules on EOS. In serum of AIRH patients the levels of IL-4, IL-5, IL-6, IL-12, IL-17 ...
Kusuhara Masahiro M Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Fukuoka, Japan; Kusuhara Dermatology Clinic, Fukuoka, - - 2014
In sporotrichosis, dermal dendritic cells were considered to participate in induction of the immune responses against Sporothrix schenckii infection. However, it is still unclear whether and how dermal dendritic cells were involved in the progress. To clarify the pathogenic role of dermal dendritic cells (DC) in sporotrichosis, we examined the ...
Grad Yonatan Y Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston - - 2014
Human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in infants and young children, and an important respiratory pathogen in the elderly and immunocompromised. While population-wide molecular epidemiology studies have shown multiple co-circulating RSV genotypes and revealed antigenic and genetic change over successive seasons, little ...
Lechner Klaus K Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, - - 2014
Bleeding and thrombosis are important complications in patients with malignant lymphomas. They may be due to direct actions of the lymphoma, such as venous compression or bone marrow infiltration, but they may also be caused by paraneoplastic phenomena, which are immune-mediated in most of the cases. The most important paraneoplastic ...
Jiao Jingjing J Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY - - 2014
Neutrophils are the most abundant cell type in the immune system and play an important role in the innate immune response. Using a diverse range of mouse models with either defective dendritic cell (DC) development or conditional DC depletion, we provide in vivo evidence indicating that conventional DCs play an ...
Zhang Qiang Q Laboratory for Bio-Organic Chemistry and Cell Biology Program, Sloan-Kettering Institute for Cancer Research, New York, NY - - 2014
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a medicinally important glycoprotein, used as an immunostimulant following bone-marrow transplant. On the basis of reports of its potential utility as an anticancer vaccine adjuvant, we undertook to develop a synthetic route toward single-glycoform GM-CSF. We describe herein a convergent total synthesis of GM-CSF aglycone ...
Gardner Jason C JC Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati College of Medicine, Cincinnati, OH - - 2014
Traumatic injury is generally considered to have a suppressive effect on the immune system, resulting in increased susceptibility to infection. Paradoxically, we found that thermal injury to the skin induced a robust time-dependent protection of mice from a lethal Klebsiella pneumoniae pulmonary challenge. The protective response was neutrophil dependent and ...
Bowcutt R R 1] Faculty of Life Sciences, University of Manchester, Manchester, UK [2] Present address: Department of Microbiology, New York University, New York, - - 2014
The ability of the colon to generate an immune response to pathogens, such as the model pathogen Trichuris muris, is a fundamental and critical defense mechanism. Resistance to T. muris infection is associated with the rapid recruitment of dendritic cells (DCs) to the colonic epithelium via epithelial chemokine production. However, ...
Parsons Matthew W MW Department of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA - - 2014
The myeloid C-type lectin receptor Dectin-2 directs the generation of Th2 and Th17 immune responses to the house dust mite Dermatophagoides farinae through the generation of cysteinyl leukotrienes and proinflammatory cytokines, respectively, but a role for Dectin-2 in effector phase responses has not been described. In this study, we demonstrate ...
- - 2014
Ionizing irradiation and PD-L1 blockade synergistically enhance antitumor immunity.
Gupta Manish M Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi-110067, - - 2014
IRF-1 is a critical hematopoietic transcription factor, which regulates cell growth, development of immune cells, immune response, tumor suppression, apoptosis and autophagy in mammalian cells. Protein-protein interactions of IRF-1 in mouse bone marrow cells (BMCs) by GST-IRF-1 pull-down followed by mass spectrometry, coimmunoprecipitation, immunoblotting and colocalization show that Regulated in ...
Zaretsky Arielle Glatman AG Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA - - 2014
The bone marrow (BM) is an important site for the interrelated processes of hematopoiesis, granulopoiesis, erythropoiesis, and lymphopoiesis. A wide variety of microbial challenges are associated with profound changes in this compartment that impact on hematopoietic differentiation and mobilization of a variety of cell types. This article reviews some of ...
Cho Dong-Im DI Research Laboratory of Cardiovascular Regeneration, Chonnam National University Hospital, Gwangju, South - - 2014
Mesenchymal stem cells (MSCs) have been widely studied for their applications in stem cell-based regeneration. During myocardial infarction (MI), infiltrated macrophages have pivotal roles in inflammation, angiogenesis and cardiac remodeling. We hypothesized that MSCs may modulate the immunologic environment to accelerate regeneration. This study was designed to assess the functional ...
Wang Yi-Hao YH Department of Hematology, Tianjin Medical University General Hospital, Tianjin, - - 2014
Immune-related pancytopenia (IRP) is characterized by pancytopenia caused by autoantibody-mediated bone marrow destruction or suppression. The bone marrows of IRP patients have remarkably increased erythroblastic islands (EIs). We determined the immunoglobulin G (IgG) autoantibodies in some parts of EIs of IRP patients using immunofluorescence to investigate the biological function of ...
Giles Francis J FJ Northwestern Medicine Developmental Therapeutics Institute, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, USA, - - 2014
Acute leukaemias are a group of malignancies characterised by the invasion of the bone marrow by immature haematopoietic precursors and differentiation arrest at various maturation steps. Multiplicity of intrinsic and extrinsic factors influences the transformation and progression of leukaemia. The intrinsic factors encompass genetic alterations of cellular pathways leading to ...
Serio B B Hematology and Hematopoietic Stem Cell Transplant Center Department of Medicine and Surgery, University of Salerno , - - 2014
Hypocellular or hypoplastic myelodysplastic syndromes (HMDS) are a distinct subgroup accounting for 10-15% of all MDS patients, that are characterized by the presence of bone marrow (BM) hypocellularity, various degree of dysmyelopoiesis and sometimes abnormal karyotype. Laboratory and clinical evidence suggest that HMDS share several immune-mediated pathogenic mechanisms with acquired ...
Columbaro Marta M SC Laboratory of Musculoskeletal Cell Biology, IOR, Bologna, - - 2014
Fanconi anemia (FA) is a genetic disorder characterised by chromosome instability, cytokine ipersensibility, bone marrow failure and abnormal haematopoiesis associated with acute myelogenous leukemia. Recent reports are contributing to characterize the peculiar FA metabolism. Central to these considerations appears that cells from complementation group A (FANCA) display an altered red-ox ...
Chou Pei-Yu PY Graduate Institute of Basic Medical Science, China Medical University, No. 91, Hsueh-Shih Road, Taichung, Taiwan ; Department of Nursing, Hung Kuang University, Taichung, - - 2014
Osteoarthritis (OA) is a mechanical abnormality associated with degradation of joints. It is characterized by chronic, progressive degeneration of articular cartilage, abnormalities of bone, and synovial change. The most common symptom of OA is local inflammation resulting from exogenous stress or endogenous abnormal cytokines. Additionally, OA is associated with local ...
Haslauer Carla M CM Department of Orthopaedic Surgery, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115 - - 2014
The response of the joint to anterior cruciate ligament (ACL) injury has not been fully characterized. In particular, the characterization of both catabolic factors, including interleukin-6 (IL-6), interleukin-8 (IL-8), and markers of ongoing tissue damage (CRP), and anabolic factors, including vascular endothelial growth factor (VEGF), transforming growth factor β-induced (TGFβI), ...
Kondo Masahiro M The First Department of Internal Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan. - - 2014
An inflammatory milieu breaks down the cartilage matrix and induces chondrocyte apoptosis, resulting in cartilage destruction in patients with cartilage degenerative diseases, such as rheumatoid arthritis or osteoarthritis. Because of the limited regenerative ability of chondrocytes, defects in cartilage are irreversible and difficult to repair. Mesenchymal stem cells (MSCs) are ...
Goto Yukinobu Y Department of Thoracic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. Electronic address: - - 2013
A bone marrow (BM) response induced by cardiopulmonary bypass (CPB) as a systemic inflammatory reaction has previously been postulated but not clarified. Newly released polymorphonuclear leukocytes (PMNs) and monocytes from the BM are known to be immature, indicating their greater potential to damage tissue. The present study aimed to examine ...
Czerner Christoph P - - 2013
Expression and function of histamine H4-receptor, an immunomodulatory receptor involved in inflammatory diseases, on murine macrophages, which are vital for immunity, were investigated. The expression pattern of histamine receptors on bone marrow-derived macrophages of BALB/c mice and on RAW 264.7 cells was studied at the mRNA level by reverse transcription ...
Yaxin Wang W Department of Anesthesiology and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, - - 2013
The recruitment of neutrophils plays an important role in the progress of acute lung injury (ALI). Excessive neutrophils released from bone marrow accumulate in lung, release proinflammatory factors, and cause tissue damage. CXCL-12/CXCR4 is an important signaling pathway, which regulates the migration of bone marrow hematopoietic cells out of bone ...
Sun Li-Fei LF Department of Tumor Research and Treatment Centricity, People's Liberation Army No. 148 Hospital, Zibo, Shandong 255300, China. Email: - - 2013
Immune-related hematocytopenia (IRH) is considered to be related with the production of autoantibody, as well as the activation of humoral immunity which is stimulated by B lymphocyte. This study aimed to observe the levels of various cytokines in the blood serum and the in situ active state of macrophage (Mφ) ...
Amdekar Sarika S Department of Microbiology, Barkatullah University, Hoshangabad Road Habibganj, Bhopal, 462026 Madhya Pradesh - - 2014
Arthritis is an inflammatory disease of joints. Exact etiology of the disease is not understood yet; but histopathological examination of vital organs like liver, kidney, ovary and knee joint can anticipate immune mediated damage. In this study, Lactobacillus acidophilus was administered orally by both prophylactic and curative protocol in freund's ...
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