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Slauenwhite Drew D Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, - - 2014
Objective: The chemokine receptor CXCR6 is highly expressed on lymphocytes isolated from the synovium of patients with rheumatoid, psoriatic, or juvenile idiopathic arthritis, suggesting that CXCR6 regulates immune cell activation or infiltration into arthritic joints. We undertook this study to examine the role of CXCR6 in T cell activation and ...
Recke Andreas A Department of Dermatology, University of Lübeck, D-23538 Lübeck, Germany; - - 2014
Subepidermal autoimmune blistering dermatoses (AIBD) are prototypic autoantibody-mediated diseases. In epidermolysis bullosa acquisita (EBA), an autoimmune disease with severe and chronic skin blistering, autoantibodies are directed against type VII collagen. IgG is the predominant autoantibody isotype of EBA, the pathogenicity of which has been demonstrated in a variety of in ...
Sorato E E Department of Biomedical Sciences, University of Padova, 35131 Padova, - - 2014
Although mitochondrial dysfunction and oxidative stress have been proposed to play a crucial role in several types of muscular dystrophy (MD), whether a causal link between these two alterations exists remains an open question. We have documented that mitochondrial dysfunction through opening of the permeability transition pore plays a key ...
Hoeksema Marten A MA Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire of macrophages may hold novel approaches for future atherosclerosis management. Here, we describe a previously unrecognized role of the epigenomic enzyme Histone deacetylase 3 (Hdac3) in regulating the atherosclerotic phenotype of ...
Iizuka Mana M Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, - - 2014
Rheumatoid arthritis (RA) is an autoimmune disease associated with the recognition of self proteins secluded in arthritic joints. We previously reported that altered peptide ligands (APLs) of type II collagen (CII256-271) suppress the development of collagen-induced arthritis (CIA). In this study, we generated transgenic rice expressing CII256-271 and APL6 contained ...
Jaffer Omar A OA University of Iowa, Internal Medicine, Iowa City, Iowa, United States ; - - 2014
Background Asthma is a disease of acute and chronic inflammation in which cytokines play a critical role in orchestrating the allergic inflammatory response. Interleukin 13 (IL-13) and transforming growth factor β (TGFβ) promote fibrotic airway remodeling, a major contributor to disease severity. Improved understanding is needed because current therapies are ...
Arunkumar Chakkaravarthy C Centre for Biotechnology, Anna University, Chennai - 600025, - - 2014
To elucidate immunoprophylactic potential of recombinant Wuchereria bancrofti (W. bancrofti) cuticular collagen (COL-4) in BALB/c mice and filarial clinical samples. col-4 gene was PCR amplified from W. bancrofti L3 cDNA library and cloned in pRSET B vector. Recombinant COL-4 was over expressed in salt inducible system and was purified by ...
Talabot-Ayer Dominique D Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland; Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, - - 2014
Previous work suggested implication of the interleukin (IL)-1 family cytokine IL-33, signaling through its receptor ST2, in the pathogenesis of human and mouse arthritis. In this study, we directly investigated the role of endogenous IL-33 in antigen-induced arthritis (AIA) and collagen-induced arthritis (CIA) using IL-33 KO mice. AIA was induced ...
Su Zhaoliang Z The Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China; Department of Immunology & Laboratory Immunology, Jiangsu University, Zhenjiang, - - 2014
High mobility group box 1 (HMGB1), an important inflammatory mediator, is actively secreted by immune cells and some non-immune cells or passively released by necrotic cells. HMGB1 has been implicated in many inflammatory diseases. Our previous published data demonstrated that HMGB1 was up-regulated in heart tissue or serum in experimental ...
Galicka Anna A Department of Medical Chemistry, Medical University of Bialystok, Białystok, Poland, - - 2014
The collagen metabolism alterations triggered by reactive oxygen species are involved in the development of various connective tissue diseases and skin aging. This study was designed to examine whether (E)-anethole possesses a protective effect on H2O2-induced alterations in collagen metabolism as well as whether it can prevent apoptosis in human ...
Parra E R ER Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, - - 2014
Limitations on tissue proliferation capacity determined by telomerase/apoptosis balance have been implicated in pathogenesis of idiopathic pulmonary fibrosis. In addition, collagen V shows promise as an inductor of apoptosis. We evaluated the quantitative relationship between the telomerase/apoptosis index, collagen V synthesis, and epithelial/fibroblast replication in mice exposed to butylated hydroxytoluene ...
Yamashita Cory M CM Department of Medicine, University of Western Ontario, London, ON, - - 2014
The matrix metalloproteinases (MMPs) encompass a family of zinc-dependent endopeptidases that are secreted into the extracellular environment or remain bound to the cell surface. While MMPs were initially identified based on their ability to degrade collagen and other components of the extracellular matrix, recent studies indicate that their non-degradative functions ...
Birukawa Naoko Kubo NK Sapporo Medical University School of Medicine, - - 2014
Stellate cells are distributed throughout organs where upon chronic damage, they become activated and proliferate to secrete collagen, that results in organ fibrosis. An intriguing property of hepatic stellate cells (HSCs) is that they undergo apoptosis when collagen is resolved by either stopping tissue damage or by treatment even though ...
Li Jun J Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, - - 2014
Objective: Fucosylation catalyzed by fucosyltransferases (FUTs) is an important post-translational modification involved in a variety of biological processes. The purpose of the current study is to determine the roles of fucosylation in rheumatoid arthritis (RA) and the efficacy of reestablishing the immune homeostasis by using 2-Deoxy-D-galactose (2-D-gal), a fucosylation inhibitor. ...
Tsenova Liana L 1 Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute (PHRI), Rutgers Biomedical and Health Sciences, Rutgers The State University of New Jersey , Newark, New - - 2014
Treatment of chronic inflammatory diseases with tumor necrosis factor alpha (TNF-α) antagonists has been associated with increased risk of tuberculosis (TB). We examined the usefulness of the rabbit model of active pulmonary TB for studying the impact of the human immune modulatory reagent etanercept on the host immune response. Control ...
Neidlinger-Wilke Cornelia C 1Institute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research, University of Ulm, 89081 Ulm, 2REPAIR-lab, Institute of Pathology, University of Mainz, Germany, 3Klinik für Orthopädie und Unfallchirurgie, Baden-Baden, Germany, 4Galenus-Klinik Stuttgart, 5Department of Orthopaedic Trauma, Hand Plastic and Reconstruction Surgery, Centre of Musculoskeletal Research, University of Ulm, 89081 Ulm, 6National Center for Spinal Disorders, Budapest, Hungary, 7Istituto Ortopedico Galeazzi, Milano, - - 2014
Study Design. Conditioned media of cartilaginous endplates (CEP) of intervertebral discs (IVD) were analyzed in a bioassay with regard to their influence on matrix turnover and inflammatory factors on nucleus pulposus (NP) cells of the same patient. CEP tissue underwent further histological and ultrastructural analysis.Objective. To identify possible interactions between ...
Ni Guo-Xin GX Department of Orthopeadics and Traumatology, Nanfang Hospital, Southern Medical University, China. Electronic address: - - 2014
To give an overview of the literature on the role of small leucine-rich proteoglycans (SLRPs) in osteoarthritis (OA) pathogenesis. Method: A literature search was performed and reviewed using the narrative approach. (1) OA is an organ disease with many tissue types and specific roles for each in the pathogenic process. ...
Umar Sadiq S Clinical Toxicology Laboratory, Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, India; Department of Biotechnology, Jamia Millia Islamia, New Delhi 110025, India. Electronic address: - - 2014
Rheumatoid arthritis (RA) is a chronic inflammatory disease which leads to destruction of joints. Current treatment modalities for RA either produce symptomatic relief (NSAIDs) or modify the disease process (DMARDs). Though effective, their use is also limited by their side effects. As a result, the interest in alternative, well tolerated ...
Wojcik Katarzyna A KA Faculty of Biology and Environmental Sciences, Department of Molecular Genetics, University of Lodz, Łódź, - - 2014
Keratoconus (KC) is a corneal disease associated with structural abnormalities in the corneal epithelium, Bowman's layer and stroma and altered concentration of tear components. KC corneas show a different pattern of collagen lamellae than their normal counterparts. Also, a reduction of several collagen types in KC epithelium and stroma was ...
Kim Mi-Sun MS R&D Center, LG Household & Healthcare Ltd., Daejeon, - - 2014
Dermal fibroblast is a primary cell type responsible for synthesis and remodeling of extracellular matrix in human skin. Type I collagen and hyaluronan are main components that have roles in skin fibrosis, wound healing, tissue remodeling as well as skin aging. Several studies have reported cytokine-dependent changes in collagen expression ...
Sprague Leslee L Biomedical Engineering Program, Russ College of Engineering and Technology, Ohio University, - - 2014
Dendritic cells (DCs) are immune cells found in peripheral tissues where they sample the organism for infections or malignancies. There they take up antigens and migrate towards immunological organs to contact and activate T lymphocytes that specifically recognize the antigen presented by these antigen presenting cells. In the steady state ...
Otsuka Fumiyuki F From CVPath Institute Inc, Gaithersburg, - - 2014
Coronary artery calcification is a well-established predictor of future cardiac events; however, it is not a predictor of unstable plaque. The intimal calcification of the atherosclerotic plaques may begin with smooth muscle cell apoptosis and release of matrix vesicles and is almost always seen microscopically in pathological intimal thickening, which ...
O'Reilly Steven S Newcastle University, United - - 2014
Fibrosis is a common and intractable condition associated with various pathologies. It is characterised by accumulation of an excessive amount of extracellular matrix molecules that primarily include collagen type I. IL-6 is a profibrotic cytokine that is elevated in the prototypic fibrotic autoimmune condition systemic sclerosis and is known to ...
Vassallo Robert R Department of Medicine, Division of Pulmonary and critical care Medicine, Mayo Clinic, Rochester, MN 55905, - - 2014
Individuals carrying DRB1*0401 who smoke cigarettes are at an increased risk of developing severe seropositive RA. To determine how cigarette smoke (CS) interacts with host genetic factors in the induction of RA-associated autoimmunity, we used transgenic mice carrying the RA-susceptible HLA genes DR4 and DQ8, but lacking all endogenous murine ...
Ghosh Sumit S Department of Veterinary and Microbiological Sciences, North Dakota State University, Dept 7690, P.O. Box 6050, Fargo, ND, 58105, USA, - - 2014
Allergic asthma is a chronic inflammatory disease of the airways characterized by excessive inflammation and remodeling of the extracellular matrix (ECM) and associated cells of the airway wall. Under inflammatory conditions, hyaluronan (HA), a major component of the ECM, undergoes dynamic changes, which may in turn affect the recruitment and ...
Lin Jun-Tang - - 2014
Atherosclerosis is now widely recognized as a chronic inflammatory disease that involves innate and adaptive immune responses. Both cellular and humoral components of the immune system have been implicated in atherogenesis. Growing evidence suggests that immune cells play crucial roles in atherogenic plaque formation. Vulnerability of the plaque probably plays ...
Li Jiang-Lin JL Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, - - 2014
The pathogenesis of hepatic fibrosis is to be further investigated. Protease-activated receptor-2 (PAR2) plays a role in hepatic fibrosis. This study aims to elucidate the role of activation of PAR2 in the regulation of hepatic stellate cell activities. In this study, the expression of PAR2, Fas and caveolin-1 in human ...
Giannandrea Matthew M Center for Lung Biology, University of Washington, Seattle, WA 98122, - - 2014
Fibrosis - a debilitating condition that can occur in most organs - is characterized by excess deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of proteinases that can degrade matrix, such as matrix metalloproteinases (MMPs), might be expected to be under-expressed in fibrosis or, if present, ...
Keshari Ravi S RS 1 Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, - - 2014
Sepsis-induced inflammation of the lung leads to acute respiratory distress syndrome (ARDS), which may trigger persistent fibrosis. The pathology of ARDS is complex and poorly understood, and the therapeutic approaches are limited. We used a baboon model of Escherichia coli sepsis that mimics the complexity of human disease to study ...
Jiao Zhijun Z Zhenjiang Key Laboratory of Medical Immunology, Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China. Electronic address: - - 2014
Recent studies have demonstrated that Notch signaling is critically involved in the regulation of immune response and contributes to autoimmune pathogenesis. Here, Notch signaling was found to be activated in CD4(+) T cells and synovial tissue from collagen-induced arthritis mice. In vivo administration of the γ-secretase inhibitor N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine t-butyl ester (DAPT) ...
Bode Gerard H GH Division of Neuroscience, School for Mental Health and Neuroscience, Faculty of Health, Medicine, and Life Sciences, Maastricht University, 6200 MD Maastricht, The - - 2014
C1q is the initiator of the classical complement pathway and, as such, is essential for efficient opsonization and clearance of pathogens, altered self-structures, and apoptotic cells. The ceramide transporter protein (CERT) and its longer splicing isoform CERTL are known to interact with extracellular matrix components, such as type IV collagen, ...
Liang Guoyan G Department of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, - - 2014
The collagen type II alpha 1 (COL2A1) mutation causes severe skeletal malformations, but the pathogenic mechanisms of how this occurs are unclear. To understand how this may happen, a col2a1 p.Gly1170Ser mutated mouse model was constructed and in homozygotes, the chondrodysplasia phenotype was observed. Misfolded procollagen was largely synthesized and ...
Lee M-R MR Department of Pharmacology and Institute of Cardiovascular Research, Medical School, Chonbuk National University, Jeonju, Chonbuk, Republic of - - 2014
Endoplasmic reticulum (ER) stress is considered one of the pathological mechanisms of idiopathic pulmonary fibrosis (IPF). Therefore, we examined whether an ER stress regulator, Bax inhibitor-1 (BI-1), regulates collagen accumulation, which is both a marker of fibrosis and a pathological mechanism of fibrosis. The presence of BI-1 inhibited the transforming ...
Manke Amruta A Department of Pharmaceutical Sciences, West Virginia University, 1, Medical Center Drive, Morgantown, WV 26506, USA. - - 2014
Given their extremely small size and light weight, carbon nanotubes (CNTs) can be readily inhaled by human lungs resulting in increased rates of pulmonary disorders, particularly fibrosis. Although the fibrogenic potential of CNTs is well established, there is a lack of consensus regarding the contribution of physicochemical attributes of CNTs ...
Peng Xueyan X Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine New Haven, CT, - - 2014
Pulmonary fibrosis is a difficult to treat, often fatal disease whose pathogenesis involves dysregulated TGF-β1 signaling. CD4+CD25+FoxP3+ Regulatory T cells ("Tregs") exert important effects on host tolerance and arise from naïve CD4+ lymphocytes in response to TGF-β1. However, the precise contribution of Tregs to experimentally induced murine lung fibrosis remains ...
Lourenço Juliana D JD Department of Medicine, University of Sao Paulo, Sao Paulo, - - 2014
To determine whether a serine protease inhibitor treatment can prevent or minimize emphysema in mice. C57BL/6 mice were subjected to porcine pancreatic elastase (PPE) nasal instillation to induce emphysema and were treated with a serine protease inhibitor (rBmTI-A) before (Protocol 1) and after (Protocol 2) emphysema development. In both protocols, ...
Ryan Brent J BJ Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, - - 2014
Tissue inflammation results in the production of numerous reactive oxygen, nitrogen and chlorine species, in addition to the products of lipid and sugar oxidation. Some of these products are capable of chemically modifying amino acids. This in turn results in changes to the structure and function of proteins. Increasing evidence ...
Gardner Humphrey H Translational Medicine, Astrazeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA, - - 2014
Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. Signaling through α1 contributes to the regulation of extracellular matrix composition, in addition to supplying in some tissues a proliferative and survival signal that appears to be unique among the collagen ...
Xu Jun J School of Medicine, University of California at San Diego La Jolla, CA, - - 2014
Liver fibrosis results from dysregulation of normal wound healing, inflammation, activation of myofibroblasts, and deposition of extracellular matrix (ECM). Chronic liver injury causes death of hepatocytes and formation of apoptotic bodies, which in turn, release factors that recruit inflammatory cells (neutrophils, monocytes, macrophages, and lymphocytes) to the injured liver. Hepatic ...
Levine Yaakov A YA SetPoint Medical Corporation, Valencia, California, United States of - - 2014
The inflammatory reflex is a physiological mechanism through which the nervous system maintains immunologic homeostasis by modulating innate and adaptive immunity. We postulated that the reflex might be harnessed therapeutically to reduce pathological levels of inflammation in rheumatoid arthritis by activating its prototypical efferent arm, termed the cholinergic anti-inflammatory pathway. ...
Jazwinski S Michal SM Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, - - 2014
The retrograde response was discovered in Saccharomyces cerevisiae as a signaling pathway from the mitochondrion to the nucleus that triggers an array of gene regulatory changes in the latter. The activation of the retrograde response compensates for the deficits associated with aging, and thus it extends yeast replicative life span. ...
De Kleer Ismé I VIB Inflammation Research Center, University of Ghent , Ghent , Belgium ; Department of Respiratory Medicine, University Hospital Ghent , Ghent , Belgium ; Department of Pulmonary Medicine, Erasmus MC , Rotterdam , - - 2014
Granulocytes, monocytes, macrophages, and dendritic cells (DCs) represent a subgroup of leukocytes, collectively called myeloid cells. During the embryonic development of mammalians, myelopoiesis occurs in a stepwise fashion that begins in the yolk sac and ends up in the bone marrow (BM). During this process, these early monocyte progenitors colonize ...
Sadeghnia Hamid Reza HR Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran ; Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran ; Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, - - 2014
In the present study, the cytotoxic and apoptogenic properties of hydroalcoholic extract and ethyl acetate (EtOAc), n-butanol, and water fractions (0-800 μg/mL) of Viola tricolor were investigated in Neuro2a mouse neuroblastoma and MCF-7 human breast cancer cells. In addition, antiangiogenic effect of EtOAc fraction was evaluated on chicken chorioallantoic membrane (CAM). ...
Nishie Wataru W Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: - - 2013
Bullous pemphigoid (BP) is a common autoimmune blistering skin disorder that tends to affect the elderly. Autoantibodies (autoAbs) from BP patients react with two hemidesmosomal components: transmembrane collagen XVII (BP180 or BPAG2) and plakin family protein BP230 (BPAG1). Of these, collagen XVII (COL17) is thought to be a major autoantigen. ...
Bleicher Françoise F Institut de Génomique Fonctionnelle de Lyon (IGFL), UMR CNRS 5242-69100 Lyon; Ecole Normale Supérieure de Lyon-69007 Lyon; Université de Lyon, Univ Lyon1, 69100-Lyon, France. Electronic address: - - 2013
Odontoblasts are post-mitotic cells organized as a layer of palisade cells along the interface between the dental pulp and dentin. They are responsible for the formation of the physiological primary and secondary dentins. They synthesize the organic matrix of type I collagen and actively participate to its mineralization by secreting ...
Jiang L - - 2013
Objectives:Many complex mechanisms responsible for the pathogenesis of pressure ulcers (PUs) currently remain poorly understood. The objective of this study was to discover the major roles for inflammatory cytokines, growth factors and several apoptosis-related signal molecules in chronic PU wound.Methods:We investigated expression of inflammatory cytokines, growth factors and their corresponding ...
Serve Kinta M - - 2013
Abstract Fibrosis, characterized by excessive collagen protein deposition, is a progressive disease that can fatally inhibit organ function. Prolonged exposure to pathogens or environmental toxicants such as asbestos can lead to chronic inflammatory responses associated with fibrosis. Significant exposure to amphibole asbestos has been reported in and around Libby, Montana ...
Putra Agus Budiawan Naro - - 2013
We previously reported that jellyfish collagen stimulates both the acquired and innate immune responses. In the acquired immune response, jellyfish collagen enhanced immunoglobulin production by lymphocytes in vitro and in vivo. Meanwhile, in the innate immune response jellyfish collagen promoted cytokine production and phagocytotic activity of macrophages. The facts that ...
Arriazu Elena - - 2013
Significance: The extracellular matrix is a dynamic microenvironment that undergoes continuous remodeling particularly during injury and wound healing. Chronic liver injury of many different etiologies such as viral hepatitis, alcohol abuse, drug-induced liver injury, obesity and insulin resistance, metabolic disorders and autoimmune disease is characterized by excessive deposition of extracellular ...
de Mesquita Fernanda C - - 2013
Hepatic stellate cells (HSC) play a key role in liver fibrogenesis. Activation of PPARγ and inhibition of fibrogenic molecules are potential strategies to block HSC activation and differentiation. Aware that the process of hepatic fibrosis involves inflammatory mediators, various anti-inflammatory substances have been studied in an attempt to revert fibrosis. ...
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