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Spector June T JT Department of Environmental & Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA; Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA. Electronic address: - - 2014
Polychlorinated biphenyl (PCB) exposure has been associated with non-Hodgkin lymphoma in several studies, and the immune system is a potential mediator. We analyzed associations of plasma PCBs with immune function measures. We hypothesized that higher plasma PCB concentrations are associated with lower immune function cross-sectionally, and that increases in PCB ...
Mabbott Neil A NA The Roslin Institute & Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK, - - 2014
Bacterial and viral infections of the gastrointestinal tract are more common in the elderly and represent a major cause of morbidity and mortality. The mucosal immune system provides the first line of defence against pathogens acquired by ingestion and inhalation, but its function is adversely affected in the elderly. This ...
Vogelweith Fanny F Université de Bourgogne, Equipe Ecologie Evolutive, UMR 6282 Biogéosciences, 6 Bd Gabriel, F-21000 Dijon, France. Electronic address: - - 2014
Natural enemies including parasitoids are the major biological cause of mortality among phytophagous insects. In response to parasitism, these insects have evolved a set of defenses to protect themselves, including behavioral, morphological, physiological and immunological barriers. According to life history theory, resources are partitioned to various functions including defense, implying ...
Murugan Raghavan R The Center for Critical Care Nephrology, CRISMA, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, - - 2014
Survivors of critical illness complicated by acute kidney injury requiring renal replacement therapy (RRT) are at an increased risk of dialysis dependence and death but the mechanisms are unknown. In a multicenter, prospective, cohort study of 817 critically ill patients receiving RRT, we examined association between Day 1 plasma inflammatory ...
Schmidt T T Departments of Dermatology, Philipps University Marburg, - - 2014
Pruritus increasingly occurs in the elderly population and is associated with a variety of dermatoses of mixed etiology. Clinical and experimental evidence suggests that senile pruritus may be linked to autoimmune events initiated by loss of self-tolerance against cutaneous autoantigens, which is facilitated by immune ageing processes. T-cell immunity, which ...
Quah Phaik Ling PL Department of Pediatrics, Yong Loo Lin School of Medicine, Republic of - - 2014
Eczema is a known risk factor for the development of wheeze in childhood. Cord blood T-cell cytokine responses have been shown to be associated with the development of both early childhood eczema and wheeze. Our objective is to study and compare the influence of intrinsic T-cell cytokine responses on the ...
Seymour L A LA Experimental Haematology, School of Medicine, Translational Research Institute, University of Queensland, Brisbane, Queensland, Australia; Pathology Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, - - 2014
Immune thrombocytopenia (ITP) is an autoimmune disorder of unknown aetiology, characterised by an isolated low platelet count in the absence of other identifiable causes. Genes influencing activation of the immune system have been identified as influencing predisposition. Killer cell immunoglobulin-like receptors (KIR) control T-cell and natural killer (NK) cell function ...
Geevarghese Bessey B Department of Pediatrics; University of Colorado; Anschutz Medical Center; Aurora, CO - - 2014
We evaluated the cell-mediated immune (CMI) response to RSV acute infection including the magnitude, kinetics and correlates with morbidity and age. Twenty-nine RSV-infected patients with mean ± SD age of 15 ± 14 months were enrolled during their 1st week of disease. Th1, Th2, Th9, Th17 and Th22 responses were ...
Akinsanya-Beysolow Iyabode - - 2014
Each year, the Advisory Committee on Immunization Practices (ACIP) reviews the recommended immunization schedules for persons aged 0 through 18 years to ensure that the schedules reflect current recommendations for Food and Drug Administration-licensed vaccines. In October 2013, ACIP approved the recommended immunization schedules for persons aged 0 through 18 ...
Saghazadeh Amene - - 2014
Abstract Activation of proinflammatory and anti-inflammatory cytokines network seems to have a role in febrile seizures (FS). The present meta-analysis was aimed to pool the inconsistent data provided with case-control studies on the relationship of proinflammatory and anti-inflammatory cytokines and FS/epilepsy risk. The genotype interleukin (IL)-1α-889 1/1 (recessive model) was ...
Krams I A IA Institute of Systematic Biology, University of Daugavpils, Daugavpils, Latvia; Institute of Ecology and Earth Sciences, University of Tartu, Tartu, Estonia; Department of Biology, University of Turku, Turku, - - 2014
Harmful parasite infestation can cause energetically costly behavioural and immunological responses, with the potential to reduce host fitness and survival. It has been hypothesized that the energetic costs of infection cause resting metabolic rate (RMR) to increase. Furthermore, under terminal investment theory, individuals exposed to pathogens should allocate resources to ...
Bucci L L Department of Experimental, Diagnostic and Specialty Medicine and CIG-Interdepartmental Centre L. Galvani, University of Bologna, Bologna, - - 2014
Centenarians are rare and exceptional individuals characterized by a peculiar phenotype. They are the best example of healthy ageing in humans as most of them have escaped or substantially delayed the onset of major age-related diseases. Within this scenario, the purpose of the present work was to understand if immune ...
Dada Tahani T Integrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, - - 2014
Preterm infants, especially those that are exposed to prenatal intrauterine infection or inflammation, are at a major risk for adverse neurological outcomes, including cognitive, motor and behavioral disabilities. We have previously shown in a mouse model that there is an acute fetal brain insult associated with intrauterine inflammation. The objectives ...
Gaur Poonam P Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110 029, India. Electronic address: - - 2014
Altered Cytokine production can lead to immune dysfunction in cancer patients. Hence, we investigated the cytokine balance in oral squamous cell carcinoma (OSCC) patients and their significance in providing new therapeutic insights. We quantified Th17 (IL17A), Treg (TGFβ1), Th1 (IL2, IFNγ) and Th2 (IL4, IL10) like cytokines in the sera ...
Jung Myung-Hwa MH Department of Aqualife Medicine, Chonnam National University, Chonnam 550-749, Republic of Korea; Aquatic Animal Hospital, Chonnam National University, Chonnam 550-749, Republic of - - 2014
Viruses belonging to the genus Megalocytivirus cause diseases in marine fishes primarily in East and Southeast Asian countries. Rock bream iridovirus (RBIV), which is a member of the Megalocytivirus genus, causes severe mass mortalities in rock beam (Oplegnathus fasciatus) in Korea. In this study, we assessed apoptosis-related gene expression patterns ...
Beigelman Avraham A aDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital bThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri, - - 2014
Recent application of advanced culture-independent molecular techniques for the identification of microorganisms has contributed to our knowledge on the role of early-life microbial exposure and colonization in health and disease. The purpose of this review is to present the current perspectives regarding the role of microbial exposure and airway bacterial ...
Edlefsen Kerstin L KL Department of Laboratory Medicine, University of Washington Medical Center, Seattle, - - 2014
Specific associations for lymphoma in the general population suggest that chronic immune dysfunction/dysregulation may be associated with the development of B-cell non-Hodgkin lymphoma (NHL). Furthermore, polymorphisms in several cytokine genes have been associated with increased lymphoma risk, most consistently with genes for TNF and IL10. To evaluate the hypothesis that ...
Chang Hsiu-Hao HH Department of Pediatrics, National Taiwan University Hospital, College of medicine, National Taiwan University, Taipei, - - 2014
Autoantibodies against coagulation factors can develop in patients associated with autoimmune disorders, malignancies, pregnancy, and drug-induced, or dermatological diseases. These antibodies can bind to functional epitopes of individual coagulation factors, neutralize their activity or promote their clearance, and clinically leading to bleeding conditions. Among them, the most common one is ...
Lehman Dara A DA 1Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 2Department of Medicine, Stanford Immunology, Stanford University School of Medicine, California 3Department of Global Health, University of Washington, Seattle, WA 4Department of Medicine, University of Washington, Seattle, WA 5Department of Epidemiology, , University of Washington, Seattle, WA 6University of Nairobi, Nairobi, Kenya 7Coast Provincial General Hospital, Mombasa, Kenya 8Department of Biostatistics, University of Washington, Seattle, WA 9Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 10Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, - - 2014
It has been hypothesized that immune activation and inflammation may increase HIV-1 susceptibility and that cytokines may be useful biomarkers for risk. Within a prospective cohort, we conducted a nested case-control analysis of plasma cytokine levels among women who acquired HIV-1 <3 months after sampling, compared to three different control ...
Madhumitha Haridoss - - 2014
The role played by T helper cytokines under chronic, low grade inflammation as seen in type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) co-morbidity is less well studied. In the present study, we measured the serum levels of both Th1 and Th2 cytokines and correlated it with clinical risk ...
Grover Madhusudan M Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN, - - 2014
Acute infectious gastroenteritis is one of the most commonly identifiable risk factors for the development of irritable bowel syndrome (IBS). A number of bacterial, viral and parasitic pathogens have been found to be associated with the development of IBS and other functional gastrointestinal (GI) disorders. Epidemiological studies have identified demographic ...
Weinstock Robert R 1823 Sawtelle Boulevard, Los Angeles, CA 90025. - - 2014
In 2013, legislation went into effect clarifying that the Tarasoff duty in California is now unambiguously solely a duty to protect. Warning the potential victim and the police is not a requirement, but a clinician can obtain immunity from liability by using this safe harbor. In situations in which a ...
Donnelly J Peter JP Department of Haematology, Radboud University Hospital Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6545 MD, Nijmegen, The Netherlands, - - 2014
Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident ...
Del Rosario Espinoza Mora Maria M Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421, Homburg, - - 2013
Type 17 helper T (Th17) cells producing the proinflammatory signature cytokine interleukin (IL)-17 are conterregulated by regulatory T cells (Treg) producing anti-inflammatory cytokines like transforming growth factor (TGF)-β and interleukin-(IL)-10. An imbalance of the Th17/Treg-ratio toward Th17 cell subset was shown to be involved in plaque destabilization and acute myocardial ...
Thyssen J P JP National Allergy Research Centre, Department of Dermato-Allergology, Gentofte University Hospital, Hellerup, - - 2013
Atopic dermatitis and allergic contact dermatitis are both common skin diseases having an immune pathogenesis. There has been considerable interest about their inter-relationships with regard to altered susceptibility. Recent investigations have shed new light on this important question, and in this article, we explore whether there is evidence that atopic ...
Moore Wendy C WC Wake Forest School of Medicine, Center for Genomics and Personalized Medicine Research and the Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Winston-Salem, NC. Electronic address: - - 2013
Clinical cluster analysis from the Severe Asthma Research Program (SARP) identified 5 asthma subphenotypes that represent the severity spectrum of early-onset allergic asthma, late-onset severe asthma, and severe asthma with chronic obstructive pulmonary disease characteristics. Analysis of induced sputum from a subset of SARP subjects showed 4 sputum inflammatory cellular patterns. ...
Chantratita N - - 2013
Melioidosis is a severe infection caused by the flagellated bacterium Burkholderia pseudomallei. The nonsense polymorphism TLR51174C>T is associated with improved outcome in Thais with melioidosis. We hypothesized that other TLR5 variants may modulate the host response and determine outcome in melioidosis. We genotyped 12 TLR5 variants selected de novo from ...
Bozhedomov V A - - 2013
The role of antisperm antibodies (ASA) in the aetiopathogenesis of varicocoele-related male infertility remains unclear. The objective of this study was to determine whether varicocoele is associated with antisperm immune response and whether this factor provides additional affect on male fertility. We performed a multicentral, prospective study that included the ...
Pawelec Graham - - 2013
"Immunosenescence" is a loosely descriptive designation for age-associated alterations to most measures of immunity, which can be seen in all mammals examined in any detail. Both innate and adaptive immunity are affected in a manner assumed to be deleterious, but often the clinical consequences of the assessed changes are unclear ...
Contreras-Garduño J - - 2013
Immune priming is a new paradigm in innate immunity. However, most studies have focused on the benefits of priming (enhanced survival and parasite clearance after a second challenge), while little attention has been paid to the costs. In this study, both factors were investigated in Anopheles albimanus primed against Plasmodium ...
Perdijk Olaf - - 2013
The Fulani are known to have a lower parasitaemia and less clinical episodes of malaria as compared to the Dogon sympatric ethnic group, living in Mali. Higher circulating malaria-specific antibody titers and increased pro-inflammatory cytokine levels have been shown in Fulani individuals. Several studies have tried to link haptoglobin (Hp) ...
Cho Soo Jung - - 2013
Firefighters exposed to World Trade Center (WTC) dust have developed chronic rhinosinusitis (CRS) and abnormal forced expiratory volume in 1 s (FEV1). Overlapping but distinct immune responses may be responsible for the clinical manifestations of upper and lower airway injury. We investigated whether a panel of inflammatory cytokines, either associated or not ...
Gallenga Carla Enrica - - 2013
Inflammaging is a phenomenon triggered by the conjunction of chronic repetitive and subclinical inflammation from external aggressors and internal inflammatory mechanisms due to the progressive degradation of systems such as the mitochondrial function. Age-related macular degeneration is the leading cause of blindness and visual impairment in patients older than 60 years ...
Kitayama Ken - - 2013
Objective. To examine desired characteristics of an online immunization record for parents from a predominantly Latino, low-income population. Methods. Four focus groups were conducted with parents (n = 29) from an urban, primarily Latino, low-income population in New York. The data were collected and analyzed during winter 2008-2009. Results. Participants ...
Chancharoenthana Wiwat - - 2013
Hypercytokinemia plays a central role in pathogenesis and is related to the high mortality in sepsis-related acute kidney injury (AKI). Besides the established cytokines, vascular endothelial growth factor (VEGF) is demonstrated as an important factor in enhancing vascular leakage in sepsis. This prospective randomized trial was conducted to compare the ...
Manuel Oriol - - 2013
Novel strategies are needed to further reduce the burden of cytomegalovirus (CMV) disease in solid-organ transplant (SOT) recipients. Measurement of the specific cell-mediated immunity against CMV can identify the actual risk for the development of CMV disease in a given patient. Thus, immune monitoring is an attractive strategy for individualizing ...
Thewissen Kristof - - 2013
The role of the adaptive immune system and more specifically T cells in the pathogenesis of multiple sclerosis (MS) has been studied extensively. Emerging evidence suggests that dendritic cells (DCs), which are innate immune cells, also contribute to MS. This study aimed to characterize circulating DC populations in MS and ...
Xu Xiao-Jun - - 2013
Although many inflammatory cytokines are prognostic in sepsis, the utility of cytokines in evaluating disease severity in pediatric hematology/oncology patients with septic shock was rarely studied. On the other hand, a single particular cytokine is far from ideal in guiding therapeutic intervention, but combination of multiple biomarkers improves the accuracy. ...
Seys S F - - 2013
Asthma is a heterogeneous disease with various clinical, inflammatory and molecular phenotypes. We studied sputum cytokine mRNA expression patterns in an unselected group of adult asthma patients to characterize the underlying inflammatory process. Differential cell counts and cytokine mRNA (quantified by real-time PCR) were analysed on sputum from 40 controls ...
Pistone T - - 2013
Short-term semi-immunity to malaria in sub-Saharan African migrants who have recently arrived in non-endemic countries results in less severe imported malaria. Our aim was to investigate the factors associated with imported malaria that would favour the hypothesis of a 'long-term' semi-immunity to malaria in adult travellers of sub-Saharan origin living ...
Mbulaiteye S M - - 2013
We conducted a study to test the hypothesis that systemic dysregulation of Th1/Th2 cytokine levels was associated with detection of carcinogenic or overall human papillomavirus (HPV) at the cervix among 964 women residing in a rural village in Nigeria. Levels in plasma were measured for 19 cytokines, including Th1-like cytokines ...
Macfarlane S - - 2013
Ageing can result in major changes in the composition and metabolic activities of bacterial populations in the large gut and an impaired immune system. To investigate the effects of synbiotic consumption on the colonic microbiota, immune function and health status in older people. A randomised, double-blind placebo-controlled, 4-week crossover study ...
Behbod Behrooz - - 2013
Knowledge of the inhalable particulate matter components responsible for health effects is important for developing targeted regulation. In a double-blind randomised cross-over trial of controlled human exposures to concentrated ambient particles (CAPs) and their endotoxin and (1→3)-β-D-glucan components, we evaluated acute inflammatory responses. 35 healthy adults were exposed to five ...
Palacios Maria G - - 2013
Abstract The immunocompetence "pace-of-life" hypothesis proposes that fast-living organisms should invest more in innate immune defenses and less in adaptive defenses compared to slow-living ones. We found some support for this hypothesis in two life-history ecotypes of the snake Thamnophis elegans; fast-living individuals show higher levels of innate immunity compared ...
Dunshea F R - - 2013
In most countries, male pigs are physically castrated soon after birth to reduce the risk of boar taint and to avoid behaviours such as fighting and mounting. However, entire male pigs are more feed efficient and deposit less fat than barrows. In addition, many animal welfare organizations are lobbying for ...
El-Hamarneh Tania - - 2013
To investigate the immune environment of endometrial polyps (EPs). Prospective case-control study. Teaching hospital and university research laboratory. Reproductive-age women undergoing hysteroscopy dilation and curettage for benign indications. Samples were collected from women with (n = 23) and without (n = 40) EPs. Endometrial samples were immunohistochemically stained with antibodies ...
Jaremka Lisa M - - 2013
Distressed marriages enhance risk for a variety of health problems. Immune dysregulation is one potential mechanism; cross-sectional studies have demonstrated that marital distress is linked to maladaptive immune alterations. The current study filled an important gap in the literature by examining the ability of marital distress to prospectively predict immune ...
Boots Mike - - 2013
There is good evidence for costs to both the use of immune defences as well as their development and maintenance. The optimal defence will be a balance of these costs with the risk of infection and the virulence of the disease. It is therefore clear that the life-history characteristics of ...
Fedorka Kenneth M - - 2013
To improve thermoregulation in colder environments, insects are expected to darken their cuticles with melanin via the phenoloxidase cascade; a phenomenon predicted by the thermal melanin hypothesis. However, the phenoloxidase cascade also plays a significant role in insect immunity, leading to the additional hypothesis that the thermal environment indirectly shapes ...
Ventevogel Melissa S - - 2013
The thymus is a vital organ for homeostatic maintenance of the peripheral immune system. It is within this mediastinal tissue that T cells develop and are extensively educated and exported to the periphery for establishment of a functional and effective immune system. A striking paradoxical feature of this critical lymphoid ...
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