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Main Maria Eve - - 2014
Increasing the number of individuals adequately immunized to prevent illness is a goal of community health nursing, but achieving this goal among occupational groups such as farmers remains a challenge. This article shares the process and outcome of a community-based participatory research project designed to provide tetanus immunizations to farmers. ...
Manthei David M DM University of Wisconsin School of Medicine and Public - - 2014
Asthma exacerbations contribute to significant morbidity, mortality, and healthcare utilization. Furthermore, viral infections are associated with asthma exacerbations by mechanisms that are not fully understood. The aim of this analysis was to determine whether cytokine patterns in patients with colds could identify risks for subsequent asthma exacerbations. We analyzed cytokine ...
Hobbs Jennifer Leigh - - 2014
Immunization offers the best protection from influenza infection. Little evidence describes disparities in immunization uptake among low-income individuals. Higher rates of chronic disease put this population at increased risk of influenza-related complications. This analysis examines if the type of main source of household income in low-income groups affects influenza immunization ...
Hazeldine Jon J MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Immunity and Infection, University of Birmingham, Birmingham, B15 2TT, UK, - - 2014
A well-established feature of physiological ageing is altered immune function, a phenomenon termed immunesenescence. Thought to be responsible in part for the increased incidence and severity of infection reported by older adults, as well as the age-related decline in vaccine efficacy and autoimmunity, immunesenescence affects both the innate and adaptive ...
Kumar Jitender J Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Electronic address: - - 2014
Persistent organic pollutants (POPs) are toxic compounds generated through various industrial activities and have adverse effects on human health. Studies performed in cell cultures and animals have revealed that POPs can alter immune-system functioning. The complement system is part of innate immune system that helps to clear pathogens from the ...
Longo Diane M - - 2014
Single-cell network profiling (SCNP) is a multiparametric flow cytometry-based approach that simultaneously measures evoked signaling in multiple cell subsets. Previously, using the SCNP approach, age-associated immune signaling responses were identified in a cohort of 60 healthy donors. In the current study, a high-dimensional analysis of intracellular signaling was performed by ...
Merlo Julieta L JL Laboratorio de Ecofisiología, Instituto de Investigaciones Marinas y Costeras, CONICET-Universidad Nacional de Mar del Plata, Mar del Plata, Buenos Aires, Argentina; Laboratorio de Ecofisiología, CIC - Universidad Nacional de Mar del Plata, Mar del Plata, Buenos Aires, Argentina. Electronic address: - - 2014
Immune activity has been proposed to be associated with substantial costs, due to trade-offs with other functions or activities that share common resources and contribute to an animal's fitness. However, direct estimates of the cost of mounting an immune response are few and have been performed mainly in birds. Thus, ...
Pérez Martínez G G Laboratory of Lactic acid bacteria and Probiotics, Department of Food Biotechnology, Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas (CSIC), Avenida Agustín Escardino 7, 46980 Paterna (Valencia), - - 2014
Today, advances in the public health system of most countries have managed to extend notably life expectancy, however, elderly's health remain as a very serious concern. The lifelong stimulation of innate and adaptive immune systems leads to immunosenescence and, as result, to a low ability to produce immunoglobulins against pathogens ...
Bush Sean P SP Department of Emergency Medicine, Brody School of Medicine at East Carolina University, Greenville, NC. Electronic address: - - 2014
We report 2 cases of catastrophic ischemic stroke after Crotalidae polyvalent immune Fab (ovine)-treated rattlesnake envenomation, 1 fatal and the other resulting in significant permanent disability. It is possible these serious adverse events may have been related to venom factor(s), an interaction between venom and antivenom, occult patient blood dyscrasia, ...
Ayhan Gulhan G 1 Department of Chest Diseases, 2 Department of Pathology, GATA Haydarpasa Training Hospital, Istanbul, - - 2014
Bronchiectasis develops as a result of genetic and environmental factors and its etiopathogenesis is not still clear. Recent studies have revealed that inflammatory cytokines, which are formed as a result of chronic infection and inflammation, play a role in the pathogenesis of bronchiectasis. For this purpose, the level of inflammatory ...
Zoratti Edward E Division of Allergy and Immunology, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan. Electronic address: - - 2014
Recent research has emphasized the need to better discriminate asthma phenotypes and consider underlying mechanistic endotypes in epidemiologic and clinical studies. Although allergic asthma and nonallergic asthma are frequently combined into 1 disease category in observational research and clinical trials, few studies have investigated the extent to which these 2 ...
Bourke Claire D CD Institute of Immunology & Infection Research, Centre for Immunity, Infection & Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United - - 2014
Improved helminth control is required to alleviate the global burden of schistosomiasis and schistosome-associated pathologies. Current control efforts rely on the anti-helminthic drug praziquantel (PZQ), which enhances immune responses to crude schistosome antigens but does not prevent re-infection. An anti-schistosome vaccine based on Schistosoma haematobium glutathione-S-transferase (GST) is currently in ...
Ruan Qingwei Q Research Center of Aging and Medicine, Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, - - 2014
Aging is associated with the dysregulation of immune system. Despite a progressive decline in immune function resulting in hyporesponsiveness to infection and vaccination, aging is also characterized by a chronic, low-grade, pro-inflammatory condition. An elderly individual with a systemic inflammation is at an increased risk of age-related diseases. Polymorphisms in ...
Man Angela L AL Gut Health and Food Safety Institute Strategic Programme, Institute of Food Research, Norwich, United - - 2014
The vast mucosal surface of the intestine is patrolled by a large number of lymphocytes forming the intestinal immune system. Like any other system in the body, this branch of the immune system is affected by ageing. Although our knowledge on the age-associated changes of the systemic immune system has ...
Spector June T JT Department of Environmental & Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA; Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA. Electronic address: - - 2014
Polychlorinated biphenyl (PCB) exposure has been associated with non-Hodgkin lymphoma in several studies, and the immune system is a potential mediator. We analyzed associations of plasma PCBs with immune function measures. We hypothesized that higher plasma PCB concentrations are associated with lower immune function cross-sectionally, and that increases in PCB ...
Mabbott Neil A NA The Roslin Institute & Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK, - - 2014
Bacterial and viral infections of the gastrointestinal tract are more common in the elderly and represent a major cause of morbidity and mortality. The mucosal immune system provides the first line of defence against pathogens acquired by ingestion and inhalation, but its function is adversely affected in the elderly. This ...
Vogelweith Fanny F Université de Bourgogne, Equipe Ecologie Evolutive, UMR 6282 Biogéosciences, 6 Bd Gabriel, F-21000 Dijon, France. Electronic address: - - 2014
Natural enemies including parasitoids are the major biological cause of mortality among phytophagous insects. In response to parasitism, these insects have evolved a set of defenses to protect themselves, including behavioral, morphological, physiological and immunological barriers. According to life history theory, resources are partitioned to various functions including defense, implying ...
Murugan Raghavan R The Center for Critical Care Nephrology, CRISMA, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, - - 2014
Survivors of critical illness complicated by acute kidney injury requiring renal replacement therapy (RRT) are at an increased risk of dialysis dependence and death but the mechanisms are unknown. In a multicenter, prospective, cohort study of 817 critically ill patients receiving RRT, we examined association between Day 1 plasma inflammatory ...
Schmidt T T Departments of Dermatology, Philipps University Marburg, - - 2014
Pruritus increasingly occurs in the elderly population and is associated with a variety of dermatoses of mixed etiology. Clinical and experimental evidence suggests that senile pruritus may be linked to autoimmune events initiated by loss of self-tolerance against cutaneous autoantigens, which is facilitated by immune ageing processes. T-cell immunity, which ...
Quah Phaik Ling PL Department of Pediatrics, Yong Loo Lin School of Medicine, Republic of - - 2014
Eczema is a known risk factor for the development of wheeze in childhood. Cord blood T-cell cytokine responses have been shown to be associated with the development of both early childhood eczema and wheeze. Our objective is to study and compare the influence of intrinsic T-cell cytokine responses on the ...
Seymour L A LA Experimental Haematology, School of Medicine, Translational Research Institute, University of Queensland, Brisbane, Queensland, Australia; Pathology Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, - - 2014
Immune thrombocytopenia (ITP) is an autoimmune disorder of unknown aetiology, characterised by an isolated low platelet count in the absence of other identifiable causes. Genes influencing activation of the immune system have been identified as influencing predisposition. Killer cell immunoglobulin-like receptors (KIR) control T-cell and natural killer (NK) cell function ...
Geevarghese Bessey B Department of Pediatrics; University of Colorado; Anschutz Medical Center; Aurora, CO - - 2014
We evaluated the cell-mediated immune (CMI) response to RSV acute infection including the magnitude, kinetics and correlates with morbidity and age. Twenty-nine RSV-infected patients with mean ± SD age of 15 ± 14 months were enrolled during their 1st week of disease. Th1, Th2, Th9, Th17 and Th22 responses were ...
Akinsanya-Beysolow Iyabode - - 2014
Each year, the Advisory Committee on Immunization Practices (ACIP) reviews the recommended immunization schedules for persons aged 0 through 18 years to ensure that the schedules reflect current recommendations for Food and Drug Administration-licensed vaccines. In October 2013, ACIP approved the recommended immunization schedules for persons aged 0 through 18 ...
Saghazadeh Amene - - 2014
Abstract Activation of proinflammatory and anti-inflammatory cytokines network seems to have a role in febrile seizures (FS). The present meta-analysis was aimed to pool the inconsistent data provided with case-control studies on the relationship of proinflammatory and anti-inflammatory cytokines and FS/epilepsy risk. The genotype interleukin (IL)-1α-889 1/1 (recessive model) was ...
Krams I A IA Institute of Systematic Biology, University of Daugavpils, Daugavpils, Latvia; Institute of Ecology and Earth Sciences, University of Tartu, Tartu, Estonia; Department of Biology, University of Turku, Turku, - - 2014
Harmful parasite infestation can cause energetically costly behavioural and immunological responses, with the potential to reduce host fitness and survival. It has been hypothesized that the energetic costs of infection cause resting metabolic rate (RMR) to increase. Furthermore, under terminal investment theory, individuals exposed to pathogens should allocate resources to ...
Bucci L L Department of Experimental, Diagnostic and Specialty Medicine and CIG-Interdepartmental Centre L. Galvani, University of Bologna, Bologna, - - 2014
Centenarians are rare and exceptional individuals characterized by a peculiar phenotype. They are the best example of healthy ageing in humans as most of them have escaped or substantially delayed the onset of major age-related diseases. Within this scenario, the purpose of the present work was to understand if immune ...
Dada Tahani T Integrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, - - 2014
Preterm infants, especially those that are exposed to prenatal intrauterine infection or inflammation, are at a major risk for adverse neurological outcomes, including cognitive, motor and behavioral disabilities. We have previously shown in a mouse model that there is an acute fetal brain insult associated with intrauterine inflammation. The objectives ...
Gaur Poonam P Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110 029, India. Electronic address: - - 2014
Altered Cytokine production can lead to immune dysfunction in cancer patients. Hence, we investigated the cytokine balance in oral squamous cell carcinoma (OSCC) patients and their significance in providing new therapeutic insights. We quantified Th17 (IL17A), Treg (TGFβ1), Th1 (IL2, IFNγ) and Th2 (IL4, IL10) like cytokines in the sera ...
Jung Myung-Hwa MH Department of Aqualife Medicine, Chonnam National University, Chonnam 550-749, Republic of Korea; Aquatic Animal Hospital, Chonnam National University, Chonnam 550-749, Republic of - - 2014
Viruses belonging to the genus Megalocytivirus cause diseases in marine fishes primarily in East and Southeast Asian countries. Rock bream iridovirus (RBIV), which is a member of the Megalocytivirus genus, causes severe mass mortalities in rock beam (Oplegnathus fasciatus) in Korea. In this study, we assessed apoptosis-related gene expression patterns ...
Beigelman Avraham A aDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital bThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri, - - 2014
Recent application of advanced culture-independent molecular techniques for the identification of microorganisms has contributed to our knowledge on the role of early-life microbial exposure and colonization in health and disease. The purpose of this review is to present the current perspectives regarding the role of microbial exposure and airway bacterial ...
Edlefsen Kerstin L KL Department of Laboratory Medicine, University of Washington Medical Center, Seattle, - - 2014
Specific associations for lymphoma in the general population suggest that chronic immune dysfunction/dysregulation may be associated with the development of B-cell non-Hodgkin lymphoma (NHL). Furthermore, polymorphisms in several cytokine genes have been associated with increased lymphoma risk, most consistently with genes for TNF and IL10. To evaluate the hypothesis that ...
Chang Hsiu-Hao HH Department of Pediatrics, National Taiwan University Hospital, College of medicine, National Taiwan University, Taipei, - - 2014
Autoantibodies against coagulation factors can develop in patients associated with autoimmune disorders, malignancies, pregnancy, and drug-induced, or dermatological diseases. These antibodies can bind to functional epitopes of individual coagulation factors, neutralize their activity or promote their clearance, and clinically leading to bleeding conditions. Among them, the most common one is ...
Lehman Dara A DA 1Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 2Department of Medicine, Stanford Immunology, Stanford University School of Medicine, California 3Department of Global Health, University of Washington, Seattle, WA 4Department of Medicine, University of Washington, Seattle, WA 5Department of Epidemiology, , University of Washington, Seattle, WA 6University of Nairobi, Nairobi, Kenya 7Coast Provincial General Hospital, Mombasa, Kenya 8Department of Biostatistics, University of Washington, Seattle, WA 9Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 10Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, - - 2014
It has been hypothesized that immune activation and inflammation may increase HIV-1 susceptibility and that cytokines may be useful biomarkers for risk. Within a prospective cohort, we conducted a nested case-control analysis of plasma cytokine levels among women who acquired HIV-1 <3 months after sampling, compared to three different control ...
Madhumitha Haridoss - - 2014
The role played by T helper cytokines under chronic, low grade inflammation as seen in type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) co-morbidity is less well studied. In the present study, we measured the serum levels of both Th1 and Th2 cytokines and correlated it with clinical risk ...
Weinstock Robert R 1823 Sawtelle Boulevard, Los Angeles, CA 90025. - - 2014
In 2013, legislation went into effect clarifying that the Tarasoff duty in California is now unambiguously solely a duty to protect. Warning the potential victim and the police is not a requirement, but a clinician can obtain immunity from liability by using this safe harbor. In situations in which a ...
Donnelly J Peter JP Department of Haematology, Radboud University Hospital Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6545 MD, Nijmegen, The Netherlands, - - 2014
Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident ...
Grover Madhusudan M Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN, - - 2014
Acute infectious gastroenteritis is one of the most commonly identifiable risk factors for the development of irritable bowel syndrome (IBS). A number of bacterial, viral and parasitic pathogens have been found to be associated with the development of IBS and other functional gastrointestinal (GI) disorders. Epidemiological studies have identified demographic ...
Xu Zhijing Z Center for Biosecurity Strategy Management, Beijing Institute of Biotechnology, Beijing, P. R. - - 2014
The high incidence of emerging infectious diseases has highlighted the importance of effective immunization strategies, especially the stochastic algorithms based on local available network information. Present stochastic strategies are mainly evaluated based on classical network models, such as scale-free networks and small-world networks, and thus are insufficient. Three frequently referred ...
Morgan Nani N Center for Integrative Medicine, Division of Rheumatology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, United States of - - 2014
Psychological and health-restorative benefits of mind-body therapies have been investigated, but their impact on the immune system remain less defined. To conduct the first comprehensive review of available controlled trial evidence to evaluate the effects of mind-body therapies on the immune system, focusing on markers of inflammation and anti-viral related ...
Ruvolo Giovanni G Unit of Cardiac Surgery, Department of Surgery and Oncology, University of Palermo, 90127 Palermo, - - 2014
Thoracic aorta shows with advancing age various changes and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur as pathological entities responsible principally for the sporadic TAA onset. Little is known about their genetic, molecular, and cellular mechanisms. Recent evidence is ...
Del Rosario Espinoza Mora Maria M Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421, Homburg, - - 2013
Type 17 helper T (Th17) cells producing the proinflammatory signature cytokine interleukin (IL)-17 are conterregulated by regulatory T cells (Treg) producing anti-inflammatory cytokines like transforming growth factor (TGF)-β and interleukin-(IL)-10. An imbalance of the Th17/Treg-ratio toward Th17 cell subset was shown to be involved in plaque destabilization and acute myocardial ...
Thyssen J P JP National Allergy Research Centre, Department of Dermato-Allergology, Gentofte University Hospital, Hellerup, - - 2013
Atopic dermatitis and allergic contact dermatitis are both common skin diseases having an immune pathogenesis. There has been considerable interest about their inter-relationships with regard to altered susceptibility. Recent investigations have shed new light on this important question, and in this article, we explore whether there is evidence that atopic ...
Moore Wendy C WC Wake Forest School of Medicine, Center for Genomics and Personalized Medicine Research and the Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Winston-Salem, NC. Electronic address: - - 2013
Clinical cluster analysis from the Severe Asthma Research Program (SARP) identified 5 asthma subphenotypes that represent the severity spectrum of early-onset allergic asthma, late-onset severe asthma, and severe asthma with chronic obstructive pulmonary disease characteristics. Analysis of induced sputum from a subset of SARP subjects showed 4 sputum inflammatory cellular patterns. ...
Chantratita N - - 2013
Melioidosis is a severe infection caused by the flagellated bacterium Burkholderia pseudomallei. The nonsense polymorphism TLR51174C>T is associated with improved outcome in Thais with melioidosis. We hypothesized that other TLR5 variants may modulate the host response and determine outcome in melioidosis. We genotyped 12 TLR5 variants selected de novo from ...
Bozhedomov V A - - 2013
The role of antisperm antibodies (ASA) in the aetiopathogenesis of varicocoele-related male infertility remains unclear. The objective of this study was to determine whether varicocoele is associated with antisperm immune response and whether this factor provides additional affect on male fertility. We performed a multicentral, prospective study that included the ...
Pawelec Graham - - 2013
"Immunosenescence" is a loosely descriptive designation for age-associated alterations to most measures of immunity, which can be seen in all mammals examined in any detail. Both innate and adaptive immunity are affected in a manner assumed to be deleterious, but often the clinical consequences of the assessed changes are unclear ...
Contreras-Garduño J - - 2013
Immune priming is a new paradigm in innate immunity. However, most studies have focused on the benefits of priming (enhanced survival and parasite clearance after a second challenge), while little attention has been paid to the costs. In this study, both factors were investigated in Anopheles albimanus primed against Plasmodium ...
Perdijk Olaf - - 2013
The Fulani are known to have a lower parasitaemia and less clinical episodes of malaria as compared to the Dogon sympatric ethnic group, living in Mali. Higher circulating malaria-specific antibody titers and increased pro-inflammatory cytokine levels have been shown in Fulani individuals. Several studies have tried to link haptoglobin (Hp) ...
Cho Soo Jung - - 2013
Firefighters exposed to World Trade Center (WTC) dust have developed chronic rhinosinusitis (CRS) and abnormal forced expiratory volume in 1 s (FEV1). Overlapping but distinct immune responses may be responsible for the clinical manifestations of upper and lower airway injury. We investigated whether a panel of inflammatory cytokines, either associated or not ...
Gallenga Carla Enrica - - 2013
Inflammaging is a phenomenon triggered by the conjunction of chronic repetitive and subclinical inflammation from external aggressors and internal inflammatory mechanisms due to the progressive degradation of systems such as the mitochondrial function. Age-related macular degeneration is the leading cause of blindness and visual impairment in patients older than 60 years ...
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