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Deschner James J Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111, Bonn, Germany; Clinical Research Unit 208, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111, Bonn, - - 2014
Periodontitis is a chronic inflammatory disease of the periodontium, which is caused by pathogenic bacteria in combination with other risk factors. The bacteria induce an immunoinflammatory host response, which can lead to irreversible matrix degradation and bone resorption. Periodontitis can be successfully treated. In order to achieve regenerative periodontal healing, ...
Zhou Ershun E College of Veterinary Medicine, Jilin University, 5333#, Xian Road, Changchun 130062, PR - - 2014
Niacin has been reported to have potent anti-inflammatory effects in LPS-induced acute lung injury. However, the molecular mechanism of niacin has not been fully understood. The aim of the present study was to investigate the effects of niacin on the production of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β in LPS-induced ...
McCaslin Charles A CA Department of Pediatrics, Pediatric Pulmonology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, United - - 2014
Pseudomonas aeruginosa infection is a hallmark of lung disease in cystic fibrosis. Acute infection with P. aeruginosa profoundly inhibits alveolar macrophage clearance of apoptotic cells (efferocytosis) via direct effect of virulence factors. During chronic infection, P. aeruginosa evades host defense by decreased virulence, which includes the production or, in the ...
Jiang Chunmiao C State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, - - 2014
The skeletal and immune systems share a multitude of regulatory molecules, including cytokines, receptors, signaling molecules and signaling transducers, thereby mutually influencing each other. In recent years, several novel insights have been attained that have enhanced our current understanding of the detailed mechanisms of osteoimmunology. In orthodontic tooth movement, immune ...
Damgaard C C Section for Periodontology, Microbiology and Community Dentistry, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Infectious Diseases and Rheumatology, Institute for Inflammation Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, Massachusetts, - - 2014
Periodontitis is a highly prevalent inflammatory disease in tooth supporting tissues, induced by bacteria growing in a biofilm on tooth surfaces. Components of the complement system are present in the periodontal tissue and the system is activated in periodontitis. Continuous complement activation and modulation by bacteria within the biofilm in ...
Darveau Richard P RP Department of Periodontics, School of Dentistry, University of Washington, Seattle, WA 98195, USA. Electronic address: - - 2014
Defining the contribution of individual members of dysbiotic host-associated bacterial communities has been difficult. The recent paper by Maekawa et al. in Cell Host & Microbe describes bacterial manipulation of neutrophil responses by Porphyromonas gingivalis as a mechanism that contributes to forming a dysbiotic community.
Hajishengallis George G Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, - - 2014
In periodontitis, dysbiotic microbial communities exhibit synergistic interactions for enhanced protection from host defenses, nutrient acquisition, and persistence in an inflammatory environment. This Review discusses evidence that periodontitis-associated communities are 'inflammo-philic' (= loving or attracted to inflammation) in that they have evolved to not only endure inflammation but also to ...
Chen Shuai S School and Hospital of Stomatology, Fujian Medical University, and Stomatological Key Lab of Fujian College and University, Fuzhou, Fujian 350002, - - 2014
In this study, the effect of hyperlipidemia on immune responses to periodontal bacterial infections was investigated. Sixty male New Zealand white rabbits were equally assigned to normal diet (ND) and high-fat diet (HFD) for 6 weeks. Every six rabbits with ND or HFD were orally inoculated with live Aggregatibacter actinomycetemcomitans ...
Phelps David S DS The Center for Host defense, Inflammation, and Lung Disease (CHILD) Research, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, - - 2014
Surfactant protein A (SP-A) is involved in lung innate immunity. Humans have two SP-A genes, SFTPA1 and SFTPA2, each with several variants. We examined the in vivo effects of treatment with specific SP-A variants on the alveolar macrophage (AM) proteome from SP-A knockout (KO) mice. KO mice received either SP-A1, ...
Narasaraju T - - 2014
Frequent outbreaks caused by influenza viruses pose considerable public health threats worldwide. Virus-inflicted alveolar damage represents a major contributor of acute lung injury in influenza. We have previously demonstrated that hepatocyte growth factor (HGF) produced by macrophages enhances alveolar epithelial proliferation during influenza infection. Here, we investigated the therapeutic efficacy ...
Huang Nasi N Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, MA, - - 2014
Periodontal disease (PD) is a highly complex disease involving many factors; however, two principal facets central to initiation and progression of the majority of PD are the composition of the microbes in the sub-gingival plaque, and the host immune response to these organisms. Numerous studies point to the complexity of ...
Matthay Michael A MA Departments of Medicine and Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, - - 2014
In the last 30 years, we have learned much about the molecular, cellular, and physiological mechanisms that regulate the resolution of pulmonary edema in both the normal and the injured lung. Although the physiological mechanisms responsible for the formation of pulmonary edema were identified by 1980, the mechanisms that explain ...
Wang Cairui C Department of Geriatrics, Peking University First Hospital, Beijing 100034, - - 2014
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the first steps in the development of multiple organ failure induced by sepsis. A systemic excessive inflammatory reaction is currently the accepted mechanism of the pathogenesis of sepsis. Several studies have suggested a protective role of the peroxisome proliferator ...
Chiarella Sergio E - - 2014
Acute exposure to particulate matter (PM) air pollution causes thrombotic cardiovascular events, leading to increased mortality rates; however, the link between PM and cardiovascular dysfunction is not completely understood. We have previously shown that the release of IL-6 from alveolar macrophages is required for a prothrombotic state and acceleration of ...
Sokos D D Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, University of Amsterdam and VU University Amsterdam, Amsterdam, The - - 2014
During the last decade it has become clear that periodontal ligament fibroblasts may contribute to the in vitro differentiation of osteoclasts. We surveyed the current findings regarding their osteoclastogenesis potential. Periodontal ligament fibroblasts have the capacity to select and attract osteoclast precursors and subsequently to retract and enable migration of ...
Kearns Mark T MT University of Colorado-Denver Anschutz Medical Campus - - 2014
Apoptosis of alveolar macrophages and their subsequent clearance by neighboring phagocytes are necessary steps in the resolution of acute pulmonary inflammation. We have recently identified that activation of the Fas death receptor on the cell surface of macrophages drives macrophage apoptosis. However, the source of Fas ligand responsible for induction ...
Perry Elizabeth E Department of Rheumatology, Queen Elizabeth Hospital, Gateshead, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK, Department of Biochemistry, University of Alberta, Edmonton, Canada, Lung Immunobiology and Transplantation Group, Institute of Cellular Medicine, Newcastle University, Sir William Leech Centre, Freeman Hospital, Newcastle and Department of Rheumatology, Royal Cornwall Hospital, Truro, UK.Department of Rheumatology, Queen Elizabeth Hospital, Gateshead, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK, Department of Biochemistry, University of Alberta, Edmonton, Canada, Lung Immunobiology and Transplantation Group, Institute of Cellular Medicine, Newcastle University, Sir William Leech Centre, Freeman Hospital, Newcastle and Department of Rheumatology, Royal Cornwall Hospital, Truro, UK. - - 2014
Recent findings have highlighted the potential initiation of ACPA in sites away from the joint. Periodontitis is an example of this concept. This process in the gums appears to be independent of smoking, the main environmental risk factor for ACPA-positive RA. There is extensive literature regarding the potential role of ...
Trindade Fábio F QOPNA, Mass spectrometry center, Department of Chemistry, University of Aveiro, - - 2014
Periodontitis is a complex immune-inflammatory disease that results from a pre-established infection in gingiva, mainly due to Gram negative bacteria, that colonize deeper in gingival sulcus and latter periodontal pocket. Host inflammatory and immune responses have both protective and destructive roles. Although cytokines, prostaglandins and proteases struggle against microbial burden, ...
Doyle C J CJ Colgate Australian Clinical Dental Research Centre, School of Dentistry, The University of Adelaide, Frome Road, Adelaide, South Australia, 5005, - - 2014
Azithromycin is a macrolide antibiotic that appears to have both antibacterial and anti-inflammatory properties. This study aimed to investigate the effect of azithromycin on the production of pro-inflammatory cytokines and chemokines by human gingival fibroblasts (HGF) in vitro. The effects of azithromycin (0.1 to 10 μg/mL) on the production of interleukin-6 ...
Wallace Alison M AM St. Paul's Hospital, University of British Columbia Center for Heart Lung Innovation, 166 - 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, - - 2014
An imbalance between proteolytic enzymes and their inhibitors is thought to be involved in the pathogenesis of chronic obstructive pulmonary disease. Matrix metalloproteinase-1, also known as interstitial collagenase, has been implicated as a potentially important proteinase in the genesis of chronic obstructive pulmonary disease and, more specifically, emphysema. We performed ...
Washino Satoshi S 1Jichi Medical - - 2014
Interstitial lung disease (ILD) is a well-known adverse effect of mammalian target of rapamycin (mTOR) inhibitors. However, it remains unknown how lung toxicities are induced by mTOR inhibitors. Here, we constructed a mouse model of mTOR inhibitor-induced ILD using temsirolimus and examined the pathogenesis of the disease. Male ICR mice ...
Hajishengallis G G Department of Microbiology, University of Pennsylvania Dental School, Philadelphia, PA, - - 2014
New insights into the biological mechanisms involved in modulating periodontal inflammation and alveolar bone loss are paving the way for novel therapeutic strategies for periodontitis. The neutrophil adhesion cascade for transmigration in response to infection or inflammation is a key paradigm in immunity. Developmental endothelial locus-1 (Del-1) is one of ...
Amano A A Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, - - 2014
Periodontal disease is caused by a group of bacteria that utilize a variety of strategies and molecular mechanisms to evade or overcome host defenses. Recent research has uncovered new evidence illuminating interesting aspects of the virulence of these bacteria and their genomic variability. This paper summarizes some of the strategies ...
He Hua H Neonatology Department, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. - - 2014
Bronchopulmonary dysplasia (BPD) is characterized by alveolar simplification with decreased numbers of alveoli and increased airspace. BPD, frequently suffered by very low birth weight infants, has been closely associated with intrauterine infection. However, the underlying mechanisms of BPD remain unclear. In the present study, it was identified that administration of ...
Yumoto Hiromichi H Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8504, - - 2014
Periodontitis is a chronic inflammatory disease initiated by a microbial biofilm formed in the periodontal pocket. Gingival epithelium plays important roles as the first physical barrier to bacterial invasion and in orchestrating the innate immune reaction via toll-like receptors (TLRs), which recognize various bacterial products, and maintaining its function. Newly ...
Sarode Sachin C SC Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Maheshnagar, Pimpri, Pune - 18, Maharashtra, - - 2014
We read with the great interest and take this opportunity to discuss the article by Khaw A et al. on 'Radiation-induced oral mucositis and periodontitis - proposal for an inter-relationship'. Authors have credibly reviewed and discussed the recent evidences that provide the rationale for proposing a link between radiotherapy, periodontitis and ...
Shyamsundar Murali M Queen's University of Belfast, Centre for Infection and Immunity, Belfast, Northern Ireland, United Kingdom ; - - 2014
Rationale Increasing epithelial repair and regeneration may hasten resolution of lung injury in patients with the Acute Respiratory Distress Syndrome (ARDS). In animal models of ARDS, Keratinocyte Growth Factor (KGF) reduces injury and increases epithelial proliferation and repair. The effect of KGF in the human alveolus is unknown. Objective To ...
Goncharova Elena A EA Pulmonary, Allergy and Critical Care Division, Airways Biology Initiative, Department of Medicine, Perelman School of Medicine, Philadelphia, PA 19104, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, - - 2014
Spontaneous pneumothoraces due to lung cyst rupture afflict patients with the rare disease Birt-Hogg-Dubé (BHD) syndrome, which is caused by mutations of the tumor suppressor gene folliculin (FLCN). The underlying mechanism of the lung manifestations in BHD is unclear. We show that BHD lungs exhibit increased alveolar epithelial cell apoptosis ...
Machado-Aranda David D From the Department of Surgery, University of Michigan, Ann Arbor, - - 2014
Lung contusion (LC) is a common injury resulting from blunt thoracic trauma. LC is an important risk factor for the development acute lung injury, adult respiratory distress syndrome, and ventilator-associated pneumonia, all of which increase mortality from trauma. LC produces a nonspecific immune cellular response. Neutrophil recruitment is known to ...
Berenson Charles S CS Infectious Disease Division, Department of Veterans Affairs Western New York Healthcare System, State University of New York at Buffalo School of Medicine, , Buffalo, New York, - - 2014
Alveolar macrophages (AM) in COPD have fundamentally impaired responsiveness to Toll-like receptor 2 (TLR2) and TLR4 ligands of non-typeable Haemophilus influenzae (NTHI). However, the contribution of innate immune dysfunction to exacerbations of COPD is unexplored. We hypothesised that impaired innate AM responses in COPD extend beyond NTHI to other pathogens ...
de Aquino Sabrina G SG Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The - - 2014
Increasing epidemiologic evidence supports a link between periodontitis and rheumatoid arthritis. The actual involvement of periodontitis in the pathogenesis of rheumatoid arthritis and the underlying mechanisms remain, however, poorly understood. We investigated the influence of concomitant periodontitis on clinical and histopathologic characteristics of T cell-mediated experimental arthritis and evaluated modulation ...
Poonyagariyagorn Hataya H Johns Hopkins University School of Medicine, Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States ; - - 2014
Bronchopulmonary dysplasia (BPD), a common chronic respiratory disease following premature birth, is believed to be secondary to oxidative damage from hyperoxia and inflammation that leads to impaired alveolar formation and chronic lung dysfunction. We hypothesized that extracellular superoxide dismutase (SOD3), an antioxidant uniquely targeted to the extracellular matrix (ECM) and ...
Duarte P M PM Dental Research Division, Department of Periodontology, Guarulhos University, São Paulo, - - 2014
Microbiological and immunological hypotheses have been raised to explain the differences in the clinical manifestations of aggressive periodontitis and chronic periodontitis. However, studies comparing the cytokine/chemokine profiles in gingival crevicular fluid between these two clinical conditions have so far not been compiled. This systematic review aimed to answer the following ...
Hirsch Jan - - 2014
Ventilator induced lung injury (VILI) impacts clinical outcomes in acute respiratory distress syndrome (ARDS), which is characterized by neutrophil-mediated inflammation and loss of alveolar barrier function. Recent epidemiological studies suggest that smoking may be a risk factor for the development of ARDS. Because alveolar type II cells are central to ...
Alvira Cristina M CM Division of Critical Care Medicine Department of Pediatrics, Stanford University School of Medicine, Stanford, - - 2014
In contrast to other organs, the lung completes a significant portion of its development after term birth. During this stage of alveolarization, division of the alveolar ducts into alveolar sacs by secondary septation, and expansion of the pulmonary vasculature by means of angiogenesis markedly increase the gas exchange surface area ...
Jian Congxiang C Department of Oral and Maxillofacial Surgery, Second Affiliated Hospital, Third Military Medical University, Xinqiaozheng Street, Shapingba District, Chongqing, 400038, People's Republic of - - 2014
Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth supporting tissues. Hypoxia, the mainly changes of the plateau environment, can induce severe periodontitis by animal experiments. There is, however, very little information on hypoxia and lipopolysaccharide (LPS) induced cytokine expression in periodontal ligament (PDL) cells. In this ...
Souto Giovanna Ribeiro GR Department of Oral Surgery and Pathology. School of Dentistry. Universidade Federal de Minas Gerais, Belo Horizonte, - - 2014
Aim: To evaluate the relationship between chemokines and dendritic cells (DCs) in human chronic periodontitis (CP). Material and Methods: Gingival samples were obtained from 23 individuals with human chronic periodontitis and six samples of normal mucosa (NM) overlapping the third molar were used to control the chemokine levels. Periodontal examination ...
Li Yong Y Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Ningxia University, Yinchuan, Ningxia 750021, China; College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, - - 2014
Increasing evidence has demonstrated that the epithelial cells in the lung play crucial roles in regulating certain inflammatory responses by modulating Wnt signaling during microbial infection. However, the anti-microbial functions of Wnt signaling in alveolar epithelial cells remain elusive. In this report, we show that Wnt/β-catenin signaling is repressed in ...
Khalaf Hazem H Division of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden. Electronic address: - - 2014
Periodontitis is a chronic inflammatory disease characterized by destruction of periodontal tissue ultimately leading to bone destruction and has been associated with other inflammatory diseases, such as atherosclerosis. Attachment loss of periodontal tissue is primarily caused by host cell-derived immune responses against subgingival biofilm. The aim of the present study ...
Wachtel Marco M University Children's Hospital, Department of Oncology and Children's Research Center, Steinwiesstrasse 75, CH-8032, Zurich, - - 2014
Biological heterogeneity represents a major obstacle for cancer treatment. Therefore, characterization of treatment-relevant tumor heterogeneity is necessary to develop more effective therapies in the future. Here, we uncovered population heterogeneity among PAX/FOXO1-positive alveolar rhabdomyosarcoma by characterizing pro-survival networks initiated by FGFR4 signaling. We found that FGFR4 signaling rescues only subgroups ...
Metcalfe Hannah Jane HJ The University of Manchester; Manchester Academic Health Science Centre; University Hospital South Manchester NHS Foundation Trust; NIHR South Manchester Respiratory and Allergy Clinical Research Facility, Manchester, M23 - - 2014
Chronic Obstructive Pulmonary Disease (COPD) is characterized by an abnormal innate immune response. We have investigated the changes in the innate immune response of COPD alveolar macrophages exposed to both cigarette smoke and Toll-like Receptor (TLR) stimulation. COPD and control alveolar macrophages were exposed to cigarette smoke extract (CSE) followed ...
Nyanhanda Tafadzwa T Food Innovation, The New Zealand Institute for Plant & Food Research Ltd, Private Bag 3123, Hamilton, 3240, New - - 2014
Eosinophil recruitment to the airways is a characteristic feature of allergic asthma. Eotaxins are potent chemokines that regulate the recruitment of eosinophils to sites of inflammation. Of these, CCL26 is linked to persistent eosinophil recruitment in the later phase of an allergic response. We evaluated the effectiveness of 10 different ...
Forbes Ben B Academy of Pharmaceutical Sciences of Great Britain, UK; King's College London, Institute of Pharmaceutical Science, London SE1 9NH, - - 2014
Alveolar macrophage (AM) responses are commonly induced in inhalation toxicology studies, typically being observed as an increase in number or a vacuolated 'foamy' morphology. Discriminating between adaptive AM responses and adverse events during nonclinical and clinical development is a major scientific challenge. When measuring and interpreting induced AM responses, an ...
Kan Baotian B Department of Poisoning and Occupational Disease, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. - - 2014
In China, and other Asian countries, numerous patients have succumbed to pulmonary fibrosis induced by paquarat poisoning, but the early pathogenesis remains unclear. In this study the effect of cytokine transforming growth factor (TGF)-β1 was observed in early acute paraquat poisoning and examined the mechanism by which paraquat caused early ...
Cheng Wan-Chien WC Department of Periodontology, School of Dentistry, King's College London, London, UK; Division of Immunology, Infection & Inflammatory Disease, Centre for Molecular and Cellular Biology of Inflammation, King's College London, London, - - 2014
Periodontitis (PD) is a chronic inflammatory disease characterised by tissue inflammation and destruction of the associated alveolar bone. It is caused by the colonisation of the bacterial plaque biofilm and the resultant host immune responses in the surrounding periodontal tissues. The pro-inflammatory cytokine IL-17, and IL-17 producing CD4+ T cells ...
Mirakaj Valbona V Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Eberhard-Karls University, Tübingen, - - 2014
The hallmarks of acute lung injury (ALI) are the compromised alveolar-capillary barrier and the extravasation of leukocytes into the alveolar space. Given the fact that the peroxisome proliferator-activated receptor-γ agonist rosiglitazone holds significant anti-inflammatory properties, we aimed to evaluate whether rosiglitazone could dampen these hallmarks of local pulmonary inflammation in ...
Berggreen Ellen E Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway. Electronic address: - - 2014
Extravasated fluid, proteins and cells are returned into the circulation by lymphatic vessels that are also important in immune cell trafficking. Lymphatic vessels in gingiva are located in lamina propria, and traverse the external surface of the alveolar bone. Lack of gingival lymphatics has been shown to increase the interstitial ...
Contreras Adolfo - - 2014
Human periodontitis is associated with a wide range of bacteria and viruses and with complex innate and adaptive immune responses. Porphyromonas gingivalis, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, Treponema denticola, cytomegalovirus and other herpesviruses are major suspected pathogens of periodontitis, and a combined herpesvirus-bacterial periodontal infection can potentially explain major clinical features ...
Cekici Ali - - 2014
The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility to periodontitis appears to be determined by the host response; specifically, the magnitude of the inflammatory response and the differential activation of immune ...
Barratt Shaney S Academic Respiratory Unit School of Clinical Sciences University of Bristol Learning and Research Building Southmead Hospital Southmead BS10 - - 2014
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible fibrosing interstitial pneumonia of unknown aetiology that usually leads to respiratory failure and death within 5 years of diagnosis. Alveolar epithelial cell injury, disruption of alveolar capillary membrane integrity and abnormal vascular repair and remodelling have all been proposed as possible ...
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