Search Results
Results 1 - 50 of 1522
1 2 3 4 5 6 7 8 9 10 >
González Florencia B FB IDICER-CONICET, Institute of Clinical and Experimental Immunology of Rosario and Immunology Institute, Faculty of Medical Sciences, National University of Rosario, - - 2014
We previously showed that T. cruzi infection in C57BL/6 mice results in lethal infection linked to unbalanced pro- and anti-inflammatory mediators production. Here, we examined the dynamics of CD4(+)Foxp3(+) regulatory T (Treg) cells within this inflammatory and highly Th1-polarized environment. Treg cells showed a reduced proliferation rate and their frequency ...
Roy Susmita S Department of Pharmacology, Institute of Post Graduate Medical Education and Research, 244 B, Acharya J C Bose Road, Kolkata, 700020, West Bengal, - - 2014
Survival of the Leishmania parasite within monocytes hinges on its ability to effectively nullify their microbicidal effector mechanisms. Accordingly, this study aimed to delineate this biological niche in patients with visceral leishmaniasis (VL). In monocytes, the redox status, antigen presenting capacity, expression of Toll-like receptors (TLRs), co-stimulatory molecules (CD80/86) and ...
Corbett Yolanda Y Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, MI 20133 - - 2014
In malaria, the evidence concerning the nucleotide-binding, oligomerization domain (NOD) 2 (NOD2) receptor is fragmented and the stimuli that might activate NOD2 are not well characterized. We investigated the role of NOD2 in vitro in the response of macrophages to Plasmodium falciparum products. Immortalized or primary bone marrow derived macrophages ...
Mac-Daniel Laura L Malaria and Biology Genetics Unit, Department of Parasitology, Pasteur Institute, 28 Rue du Dr Roux, 75724 Paris Cedex 15, - - 2014
Plasmodium, the causative agent of malaria, initially multiplies inside liver cells and then in successive cycles inside erythrocytes, causing the symptoms of the disease. In this review, we discuss interactions between the extracellular and intracellular forms of the Plasmodium parasite and innate immune cells in the mammalian host, with a ...
Barreto-de-Souza Victor V Laboratory on Thymus Research, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, - - 2014
The protozoan parasite Leishmania infects and replicates in macrophages, causing a spectrum of diseases in the human host, varying from cutaneous to visceral clinical forms. It is known that cytokines modulate the immunological response against Leishmania and are relevant for infection resolution. Here, we report that Interleukin (IL)-27 increases Leishmania ...
Cousineau Susan V SV Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM1, UM2), 911 avenue Agropolis, B.P. 64501, 34394, Montpellier, Cedex 5, - - 2014
Heterogenity between sexes in terms of both the level and type of immune response to infection is documented in many species but its role on parasite evolution is only beginning to be explored. We adopt an evolutionary epidemiology approach to study how the ability of a host to reduce infection ...
Jabbour M N MN Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, - - 2014
Cutaneous leishmaniasis is an infection that has spread to non-endemic regions, stimulating recent interest for the enhanced understanding of this disease. Downregulation of the CD1a receptor on Langerhans cells has been described in various cutaneous infections. In this study, the immune response across different Ridley patterns and parasitic indices is ...
Tiwari Savitri S Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, - - 2014
Thioredoxin reductase plays crucial role in the maintenance of cellular redox homeostasis. In this study, we have targeted TrxR in Setaria cervi, a bovine filarial parasite using its inhibitor CDNB. It caused significant decrease in the motility and viability of these parasites leading to their death. Inhibition of TrxR leads ...
Poinar George G Jr Department of Zoology, Oregon State University, Corvallis, OR, 97331, USA, - - 2014
A new nematode, Tripius gyraloura n. sp., is described from the arundo gall midge, Lasioptera donacis Coutin (Diptera: Cecidomyiidae). This gall midge is being considered as a biological control agent for use in North America against the introduced giant reed Arundo donax (L.) (Poaceae: Cyperales). Thus the present study was ...
Braga Mariana P MP Laboratório de Ecologia Molecular e Parasitologia Evolutiva, Universidade Federal do Paraná, Setor de Ciências Biológicas, Departamento de Zoologia, Caixa Postal 19073, CEP 81531-980, Curitiba, PR, - - 2014
1.Because host-parasite interactions are so ubiquitous, it is of primary interest for ecologists to understand the factors that generate, maintain, and constrain these associations. Phylogenetic comparative studies have found abundant evidence for host-switching to relatively unrelated hosts, sometimes related to diversification events, in a variety of host-parasite systems. For Monogenoidea ...
Liempi A A Programa de Anatomía y Biología del Desarrollo, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, - - 2014
The congenital transmission of Trypanosoma cruzi (T. cruzi) is responsible for one-third of new Chagas disease cases each year. During congenital transmission, the parasite breaks down the placental barrier formed by the trophoblast, basal laminae and villous stroma. The observation that only 5% of infected mothers transmit the parasite to the ...
Rogan M T MT Cestode Zoonoses Research Group, School of Environment and Life Sciences, University of Salford, Salford, M54WT, - - 2014
In 1982, Rickard & Williams stated that immunity to larval taeniid cestodes, could be divided into two different phases, the establishment phase, operating against oncospheres and the established phase, operating against established metacestodes in the tissues. These concepts were largely based on experimental and veterinary data. As a result of ...
Perosso Juliana J Department of Clinical Care, Surgery and Animal Reproduction, Laboratory of Cellular Immunology, School of Veterinary Science of the São Paulo State University (Faculdade de Medicina Veterinária da Universidade Estadual Paulista "Júlio de Mesquita Filho", FMVA/UNESP), Rua Clóvis Pestana, 793, Araçatuba, São Paulo, CEP 16050-680, - - 2014
Visceral leishmaniosis (VL) is caused by intracellular parasites of the genus Leishmania that affect humans and several animal species. Dogs are one of the main urban reservoirs of Leishmania infantum and play a central role in the transmission cycle to humans via sandflies. CD3+ cells apoptosis is involved in the ...
Sanches Françoise P - - 2014
BackgroundThere are only a few studies reporting the role of nitric oxide metabolites for controlling macrophage intracellular parasitism, and these are controversial. Therefore, the present study aimed to evaluate the expression of inducible nitric oxide synthase (iNOS) in the lymph nodes and spleen of dogs affected by visceral leishmaniasis through ...
Muñoz-Caro Tamara T Institute of Parasitology, BFS, Justus Liebig University Giessen, Schubertstraße 81, 35392, Giessen, - - 2014
Extracellular trap (ET) formation has been demonstrated as an important novel effector mechanism of polymorphonuclear neutrophils (PMN), eosinophils, mast cells and macrophages acting extracellularly against pathogens. In the present study, we show that tachyzoites of the emerging apicomplexan parasite Besnoitia besnoiti, that have recently been reported as potent inducers of ...
Schmitz Veronica V Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941, Brazil; Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040, - - 2014
Complement and the kallikrein-kinin cascade system are both activated in injured tissues. Little is known about their partnership in the immunopathogenesis of Chagas disease, the chronic infection caused by the intracellular protozoan Trypanosoma cruzi. In this study, we show that pharmacological targeting of the C5a receptor (C5aR) or the bradykinin ...
Poonyagariyagorn Hataya K HK 1 Division of Pulmonary and Critical Care Medicine - - 2014
Bronchopulmonary dysplasia (BPD), a common chronic respiratory disease that occurs after premature birth, is believed to be secondary to oxidative damage from hyperoxia and inflammation, which leads to impaired alveolar formation and chronic lung dysfunction. We hypothesized that extracellular superoxide dismutase (SOD)3, an antioxidant uniquely targeted to the extracellular matrix ...
Chen Fei F 1] Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, New Jersey, USA. [2] Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, New Jersey, - - 2014
We examined the role of innate cells in acquired resistance to the natural murine parasitic nematode, Nippostrongylus brasiliensis. Macrophages obtained from lungs as late as 45 d after N. brasiliensis inoculation were able to transfer accelerated parasite clearance to naive recipients. Primed macrophages adhered to larvae in vitro and triggered ...
Yousefi Elham - - 2014
Leishmaniasis is a complex protozoan disease comprising a wide range of clinical manifestations that is usually divided into visceral leishmaniasis, cutaneous leishmaniasis, and muco-cutaneous leishmaniasis depending on leishmania parasite species and host's immune system responses. Most of the drugs produced for the treatment of leishmaniasis, from the first used to ...
Han Seong-Ji SJ Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California-Berkeley, Berkeley, CA, - - 2014
The classic anti-viral cytokine interferon (IFN)-β can be induced during parasitic infection, but relatively little is know about the cell types and signaling pathways involved. Here we show that inflammatory monocytes (IMs), but not neutrophils, produce IFN-β in response to T. gondii infection. This difference correlated with the mode of ...
Fernández-Villegas Ana A Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento s/n, 18016 Granada, - - 2014
The innate immune response from diamniotic and dichorionic twin brothers congenitally infected with Trypanosoma. cruzi (strain DTU-V) who displayed different clinical symptomatology was studied. While Brother I manifested severe cardiac and digestive disorders, the Brother II showed slight splenomegaly. The secretion level of IL-1β, TNF-α, IL-12, IL-10, IFN-α and IL-6 ...
Cribbs Sushma K SK 49 Jesse Hill Jr Dr(FOB) PulmonaryAtlanta, Georgia, United States , 30303 ; - - 2014
Objective: To quantify HIV viral load within the alveolar macrophage in a cohort of healthy HIV-infected subjects who did not have medical co-morbidities or smoke cigarettes, and to determine if alveolar macrophage proviral DNA was associated with alveolar macrophage phagocytic immune dysfunction. Design: Prospective cross-sectional study Methods: We enrolled 23 ...
Pushalkar Smruti S Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, - - 2014
Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate (BP)-related osteonecrosis of the jaw (ONJ) or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to ...
Vir Pooja P Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Sector-12, Chandigarh, 160012, - - 2014
Mycobacterium tuberculosis (M. tb), an intracellular pathogen, has the ability to infect alveolar epithelial cells (AEC) also in addition to alveolar macrophages. The virulence of M. tb is attributed to proteins encoded by genomic regions of deletion (RD) and till date 16 such regions (RD1-RD16) have been identified. Culture filtrate ...
Copenhaver Alan M AM Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of - - 2014
Legionella pneumophila, an intracellular pathogen responsible for the severe pneumonia Legionnaires' disease, uses its dot/icm-encoded type IV secretion system (T4SS) to translocate effector proteins that promote its survival and replication into the host cell cytosol. However, by introducing bacterial products into the host cytosol, L. pneumophila also activates cytosolic immunosurveillance ...
Nikota Jake K JK Medical Sciences Graduate Program, McMaster University, Hamilton, Ontario L8S 4K1, - - 2014
Cigarette smoke has a broad impact on the mucosal environment with the ability to alter host defense mechanisms. Within the context of a bacterial infection, this altered host response is often accompanied by exacerbated cellular inflammation, characterized by increased neutrophilia. The current study investigated the mechanisms of neutrophil recruitment in ...
Krupa Agnieszka A - - 2014
Previous observations made by our laboratory indicate that Bruton's tyrosine kinase (Btk) may play an important role in the pathophysiology of local inflammation in ALI/ARDS. We have also shown that there is cross talk between FcγRIIa and TLR4 in alveolar neutrophils from patients with ALI/ARDS and that Btk mediates the ...
Hazan-Molina H H Orthodontic and Craniofacial Department, Graduate School of Dentistry, Rambam Health Care Campus and the Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, - - 2014
Extracorporeal shock wave therapy has been used in various clinical conditions as a result of its ability to stimulate healing processes in acute and chronic inflammatory states. Orthodontic force application triggers an inflammatory reaction in the periodontal tissue surrounding the involved teeth, resulting in tooth movement. Preliminary work revealed that ...
Palm Eleonor E Örebro University, School of Health and Medical Sciences, Department of Biomedicine, Örebro, - - 2014
The interaction between human gingival fibroblasts (HGFs) and Porphyromonas gingivalis plays an important role in the development and progression of periodontitis. P. gingivalis possesses several virulence factors, including cysteine proteases, the arginine-specific (Rgp) and lysine-specific (Kgp) gingipains. Studying the mechanisms that P. gingivalis, and its derived virulence, use to propagate ...
Garlet G P GP Department of Biological Sciences, School of Dentistry of Bauru, São Paulo University (FOB/USP), Bauru, SP, Brazil - - 2014
The disruption of host-microbe homeostasis at the site of periodontal disease is considered a key factor for disease initiation and progress. While the downstream mechanisms responsible for the tissue damage per se are relatively well-known (involving various patterns of immune response operating toward periodontal tissue destruction), we are only beginning ...
Deschner James J Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111, Bonn, Germany; Clinical Research Unit 208, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111, Bonn, - - 2014
Periodontitis is a chronic inflammatory disease of the periodontium, which is caused by pathogenic bacteria in combination with other risk factors. The bacteria induce an immunoinflammatory host response, which can lead to irreversible matrix degradation and bone resorption. Periodontitis can be successfully treated. In order to achieve regenerative periodontal healing, ...
Zhou Ershun E College of Veterinary Medicine, Jilin University, 5333#, Xian Road, Changchun 130062, PR - - 2014
Niacin has been reported to have potent anti-inflammatory effects in LPS-induced acute lung injury. However, the molecular mechanism of niacin has not been fully understood. The aim of the present study was to investigate the effects of niacin on the production of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β in LPS-induced ...
McCaslin Charles A CA Department of Pediatrics, Pediatric Pulmonology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, United - - 2014
Pseudomonas aeruginosa infection is a hallmark of lung disease in cystic fibrosis. Acute infection with P. aeruginosa profoundly inhibits alveolar macrophage clearance of apoptotic cells (efferocytosis) via direct effect of virulence factors. During chronic infection, P. aeruginosa evades host defense by decreased virulence, which includes the production or, in the ...
Jiang Chunmiao C State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, - - 2014
The skeletal and immune systems share a multitude of regulatory molecules, including cytokines, receptors, signaling molecules and signaling transducers, thereby mutually influencing each other. In recent years, several novel insights have been attained that have enhanced our current understanding of the detailed mechanisms of osteoimmunology. In orthodontic tooth movement, immune ...
Damgaard C C Section for Periodontology, Microbiology and Community Dentistry, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Infectious Diseases and Rheumatology, Institute for Inflammation Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, Massachusetts, - - 2014
Periodontitis is a highly prevalent inflammatory disease in tooth supporting tissues, induced by bacteria growing in a biofilm on tooth surfaces. Components of the complement system are present in the periodontal tissue and the system is activated in periodontitis. Continuous complement activation and modulation by bacteria within the biofilm in ...
Darveau Richard P RP Department of Periodontics, School of Dentistry, University of Washington, Seattle, WA 98195, USA. Electronic address: - - 2014
Defining the contribution of individual members of dysbiotic host-associated bacterial communities has been difficult. The recent paper by Maekawa et al. in Cell Host & Microbe describes bacterial manipulation of neutrophil responses by Porphyromonas gingivalis as a mechanism that contributes to forming a dysbiotic community.
Hajishengallis George G Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, - - 2014
In periodontitis, dysbiotic microbial communities exhibit synergistic interactions for enhanced protection from host defenses, nutrient acquisition, and persistence in an inflammatory environment. This Review discusses evidence that periodontitis-associated communities are 'inflammo-philic' (= loving or attracted to inflammation) in that they have evolved to not only endure inflammation but also to ...
Chen Shuai S School and Hospital of Stomatology, Fujian Medical University, and Stomatological Key Lab of Fujian College and University, Fuzhou, Fujian 350002, - - 2014
In this study, the effect of hyperlipidemia on immune responses to periodontal bacterial infections was investigated. Sixty male New Zealand white rabbits were equally assigned to normal diet (ND) and high-fat diet (HFD) for 6 weeks. Every six rabbits with ND or HFD were orally inoculated with live Aggregatibacter actinomycetemcomitans ...
Phelps David S DS The Center for Host defense, Inflammation, and Lung Disease (CHILD) Research, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, - - 2014
Surfactant protein A (SP-A) is involved in lung innate immunity. Humans have two SP-A genes, SFTPA1 and SFTPA2, each with several variants. We examined the in vivo effects of treatment with specific SP-A variants on the alveolar macrophage (AM) proteome from SP-A knockout (KO) mice. KO mice received either SP-A1, ...
Shyamsundar Murali M 1 Centre for Infection and Immunity, Queen's University of Belfast, Belfast, United Kingdom; - - 2014
Increasing epithelial repair and regeneration may hasten resolution of lung injury in patients with the acute respiratory distress syndrome (ARDS). In animal models of ARDS, keratinocyte growth factor (KGF) reduces injury and increases epithelial proliferation and repair. The effect of KGF in the human alveolus is unknown. To test whether ...
Narasaraju T - - 2014
Frequent outbreaks caused by influenza viruses pose considerable public health threats worldwide. Virus-inflicted alveolar damage represents a major contributor of acute lung injury in influenza. We have previously demonstrated that hepatocyte growth factor (HGF) produced by macrophages enhances alveolar epithelial proliferation during influenza infection. Here, we investigated the therapeutic efficacy ...
Huang Nasi N Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, MA, - - 2014
Periodontal disease (PD) is a highly complex disease involving many factors; however, two principal facets central to initiation and progression of the majority of PD are the composition of the microbes in the sub-gingival plaque, and the host immune response to these organisms. Numerous studies point to the complexity of ...
Wang Cairui C Department of Geriatrics, Peking University First Hospital, Beijing 100034, - - 2014
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the first steps in the development of multiple organ failure induced by sepsis. A systemic excessive inflammatory reaction is currently the accepted mechanism of the pathogenesis of sepsis. Several studies have suggested a protective role of the peroxisome proliferator ...
Matthay Michael A MA Departments of Medicine and Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, - - 2014
In the last 30 years, we have learned much about the molecular, cellular, and physiological mechanisms that regulate the resolution of pulmonary edema in both the normal and the injured lung. Although the physiological mechanisms responsible for the formation of pulmonary edema were identified by 1980, the mechanisms that explain ...
Chiarella Sergio E - - 2014
Acute exposure to particulate matter (PM) air pollution causes thrombotic cardiovascular events, leading to increased mortality rates; however, the link between PM and cardiovascular dysfunction is not completely understood. We have previously shown that the release of IL-6 from alveolar macrophages is required for a prothrombotic state and acceleration of ...
Sokos D D Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, University of Amsterdam and VU University Amsterdam, Amsterdam, The - - 2014
During the last decade it has become clear that periodontal ligament fibroblasts may contribute to the in vitro differentiation of osteoclasts. We surveyed the current findings regarding their osteoclastogenesis potential. Periodontal ligament fibroblasts have the capacity to select and attract osteoclast precursors and subsequently to retract and enable migration of ...
Kearns Mark T MT University of Colorado-Denver Anschutz Medical Campus - - 2014
Apoptosis of alveolar macrophages and their subsequent clearance by neighboring phagocytes are necessary steps in the resolution of acute pulmonary inflammation. We have recently identified that activation of the Fas death receptor on the cell surface of macrophages drives macrophage apoptosis. However, the source of Fas ligand responsible for induction ...
Perry Elizabeth E Department of Rheumatology, Queen Elizabeth Hospital, Gateshead, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK, Department of Biochemistry, University of Alberta, Edmonton, Canada, Lung Immunobiology and Transplantation Group, Institute of Cellular Medicine, Newcastle University, Sir William Leech Centre, Freeman Hospital, Newcastle and Department of Rheumatology, Royal Cornwall Hospital, Truro, UK.Department of Rheumatology, Queen Elizabeth Hospital, Gateshead, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK, Department of Biochemistry, University of Alberta, Edmonton, Canada, Lung Immunobiology and Transplantation Group, Institute of Cellular Medicine, Newcastle University, Sir William Leech Centre, Freeman Hospital, Newcastle and Department of Rheumatology, Royal Cornwall Hospital, Truro, UK. - - 2014
Recent findings have highlighted the potential initiation of ACPA in sites away from the joint. Periodontitis is an example of this concept. This process in the gums appears to be independent of smoking, the main environmental risk factor for ACPA-positive RA. There is extensive literature regarding the potential role of ...
Trindade Fábio F QOPNA, Mass spectrometry center, Department of Chemistry, University of Aveiro, - - 2014
Periodontitis is a complex immune-inflammatory disease that results from a pre-established infection in gingiva, mainly due to Gram negative bacteria, that colonize deeper in gingival sulcus and latter periodontal pocket. Host inflammatory and immune responses have both protective and destructive roles. Although cytokines, prostaglandins and proteases struggle against microbial burden, ...
Doyle C J CJ Colgate Australian Clinical Dental Research Centre, School of Dentistry, The University of Adelaide, Frome Road, Adelaide, South Australia, 5005, - - 2014
Azithromycin is a macrolide antibiotic that appears to have both antibacterial and anti-inflammatory properties. This study aimed to investigate the effect of azithromycin on the production of pro-inflammatory cytokines and chemokines by human gingival fibroblasts (HGF) in vitro. The effects of azithromycin (0.1 to 10 μg/mL) on the production of interleukin-6 ...
1 2 3 4 5 6 7 8 9 10 >