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Yu Jian J Center for safety evaluation, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, - - 2014
'SHENMAI' injection (SMI) has been widely used in cardioprotection and modulation of the immune system because of its great efficacy. SMI primarily comprises the saponins from Panax ginseng and Ophiopogon japonicas. The profiles of saponins in SMI during long-term toxicokinetics remain unclear. MiR-146a possesses excellent sensitivity as a bio-marker in ...
Zhu Yao Y 1] Departments of Neurology, The 105th Hospital of PLA, Hefei 230031, China [2] Clinic College, Anhui Medical University, Hefei 230032, - - 2014
Aim:Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) have been shown to ameliorate cerebral ischemia in animal models. In this study we investigated the effects of hUCB-MSCs on inflammatory responses and neuronal apoptosis during the early stage of focal cerebral ischemia in rabbits.Methods:Focal cerebral ischemia was induced in male New ...
Chen Fangyuan F aDepartment of Cardiovascular Medicine, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China bDepartment of Forensic Medicine, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China cKey Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an 710061, Shaanxi, - - 2014
This study aimed to investigate the effects of curcumin on macrophages polarization and possible mechanism involved, and to analyze the molecular basis of its anti-atherosclerosis activity. RAW264.7 macrophages (M0) and M1 macrophages were treated with curcumin at 0, 6.25, 12.5 and 25μmol/L with or without GW9662. Using real-time PCR and ...
Fatemi Farnaz F Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, - - 2014
Asthma is a chronic and heterogeneous inflammatory disorder with several different phenotypes. Whereas clinical features of asthma are non-specific and pulmonary function tests are often insensitive, further development is needed for efficient treatment or even early diagnosis. Recently, several airway inflammatory biomarkers have emerged as valuable tools in diagnosis and ...
Upthegrove Rachel R Department of Psychiatry, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK; Early Intervention Service, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK. Electronic address: - - 2014
This systematic review sets out to give a comprehensive overview of the cytokine profile at the onset of psychosis un-confounded by medication. We aim to provide insight into the early pathophysiological process of psychosis and areas for future research of potential biomarkers able to chart the extent of illness or ...
Bagheri Bahador B Shahid Madani Heart Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. - - 2014
Bacground: Evidence from several lines of investigations suggests that Toll-like receptor 4 (TLR4) is involved in atherosclerosis as a bridge between innate and acquired immunity. Percutaneous coronary intervention (PCI) can trigger inflammation through activation of human TLR4 (hTLR4) on monocytes. Hydrocortisone as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms ...
Tai Katsunori K First Department of Internal - - 2014
Tetracyclines are administered to cure Japanese spotted fever (JSF) and tsutsugamushi disease (TD). It is generally said that the clinical course of JSF is worse despite antibiotic treatment than that of TD. The precise mechanism underlying the more severe clinical course of JSF is not fully understood. We therefore examined ...
Dudemaine P L PL Dairy and Swine Research and Development Centre, Agriculture and Agri-Food Canada, Sherbrooke, QC, Canada J1M 1Z3; Département de biochimie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, QC, Canada J1H - - 2014
Paratuberculosis-infected cattle initially develop an effective cell-mediated immune response that declines as the disease progresses. Blood is one of best sources for characterizing the inflammatory status of infected cows and for studying mediators related to chronic diseases. The aim of this study was to evaluate the cow-level association between blood ...
Childs Caroline E CE Department of Food and Nutritional Sciences, The University of Reading, Reading RG6 6AP, - - 2014
Prebiotics, probiotics and synbiotics are dietary ingredients with the potential to influence health and mucosal and systemic immune function by altering the composition of the gut microbiota. In the present study, a candidate prebiotic (xylo-oligosaccharide, XOS, 8 g/d), probiotic (Bifidobacterium animalis subsp. lactis Bi-07, 109 colony-forming units (CFU)/d) or synbiotic (8 g ...
Erbel Christian C 1Department of Cardiology, University of Heidelberg, Heidelberg, - - 2014
Macrophage heterogeneity in human atherosclerotic plaques has been recognized; however, markers for unequivocal identification of some subtypes are lacking. We found that the platelet chemokine CXCL4 induces a unique macrophage phenotype, which we proposed to call 'M4'. Here, we sought to identify suitable markers that identify M4 macrophages in vitro and ...
Douxfils J J University of Namur (UNamur), Research Unit in Environmental and Evolutionary Biology (URBE), Rue de Bruxelles, 61, B-5000, Namur, - - 2014
Domestication might be a possible way to reduce the physiological response to long-term stressors and deleterious effects on immunity. The present study aimed to evaluate the chronic immune response induced by repeated emersions and the possible impact of domestication by comparing farmed Eurasian perch with short (F1) and long (F4) ...
Zhan Yanxia Y Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, - - 2014
Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder which is characterized by decreased platelet count. Serum cytokines play an important role in the pathogenesis of ITP by initiating and perpetuating various cellular and humoral autoimmune processes. To investigate a broad spectrum of cytokines in ITP patients and the effects ...
Ye Liang - - 2014
Interleukin-37 (IL-37), a new member of IL-1 family cytokine, is recently identified as a natural inhibitor of innate immunity. This study aimed to measure the peripheral blood mononuclear cells (PBMCs) and serum levels of IL-37 in patients with systemic lupus erythematosus (SLE) and to investigate its role in SLE, including ...
Ohlsson Susanne M SM Department of Clinical Sciences in Lund, Section of Nephrology, Lund University, BMC B13, 221 84 Lund, - - 2014
Anti-neutrophil cytoplasmic antibody associated vasculitides (AAV) are conditions defined by an autoimmune small vessel inflammation. Dying neutrophils are found around the inflamed vessels and the balance between infiltrating neutrophils and macrophages is important to prevent autoimmunity. Here we investigate how sera from AAV patients may regulate macrophage polarization and function. ...
Rodrigues Rodrigo R Programa de Pós-Graduação em Bioquímica e Bioprospecção, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, - - 2014
Subjects with Down syndrome (DS) have an increased susceptibility to infections and autoimmune disorders. ATP, adenosine, and acetylcholine contribute to the immune response regulation, and NTPDase, adenosine deaminase (ADA) and acetylcholinesterase (AChE) are important enzymes in the control of the extracellular levels of these molecules. We evaluated the activities of ...
Wang Xian-Feng XF Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou, PR China; Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, PR - - 2014
Macrophages can be divided into two groups as M1 and M2 phenotype. Our results and other groups revealed that IFN-γ can up-regulate the IDO expression and differentiate THP-1 cells to M1 phenotype. Therefore we hypothesized that IDO may play potential roles in macrophage differentiation. Interesting, our results indicated that the ...
Hattab Suhaib - - 2014
Few studies have compared the impact of different antiretroviral regimens on residual immune activation and inflammation with discordant results. Aim of the study was to investigate the impact of various antiretroviral regimens on markers of immune activation and inflammation during the first two years of effective therapy. We studied HIV-infected ...
Philip Anju M AM Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, - - 2014
Anadromous Arctic charr (Salvelinus alpinus) undergo voluntary winter fasting for months in the Arctic. We tested the hypothesis that extended fasting will compromise the ability of this species to evoke an immune response. Charr were either fed or fasted for 85 days and challenged with lipopolysaccharide (LPS), and the molecular ...
Wang Lin L Department of Laboratory Medicine, Key Laboratory of Clinical Immunology of Jiangsu Province, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. - - 2014
Chronic hepatitis B (CHB) is one of the most common types of infectious diseases worldwide. The interaction between hepatitis B virus (HBV) and the host immune response is vital for the clinical outcome of HBV infection. Costimulatory signals are key factors for the host immune response and play a critical ...
Farhadi Naser N Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, - - 2014
Cytokines are important factors of the immune system in autoimmune diseases such as multiple sclerosis (MS) in which damage caused by oxidants plays a major role in the pathology. Melatonin secreted by the pineal gland has recently been considered as an antioxidant. The purpose of this study was to determine ...
Knez Wade W ASPETAR, Qatar Orthopaedic and Sports Medicine Hospital, Research and Education Centre, - - 2014
This study investigated the effect of living (summer vs. winter) and working (morning vs. afternoon) in a hot environment on markers of immune function and forearm strength. Thirty-one healthy male gas field employees were screened before (between 05:30 and 07:00) and after their working day (between 15:30 and 17:00) during ...
Frede Natalie - - 2014
Inflammatory bowel disease constitutes a heterogeneous group of conditions, whose aetiology is only partly understood. The prevailing hypothesis on its pathogenesis is that IBD is the result of an inadequate immune response to the resident bacterial flora of the intestine. An autoimmune background, however, has been discussed since the 1950s. ...
Brosseron Frederic F German Center for Neurodegenerative Diseases (DZNE), Bonn, - - 2014
This article gives a comprehensive overview of cytokine and other inflammation associated protein levels in plasma, serum and cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). We reviewed 118 research articles published between 1989 and 2013 to compare the reported levels of 66 cytokines ...
Bennett William D WD 1 Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina (UNC) at Chapel Hill , - - 2014
Abstract Background: In healthy nonsmokers, inhaled endotoxin [lipopolysaccharide (LPS)] challenge induces airway neutrophilia and modifies innate immune responses, but the effect on mucociliary clearance (MCC), a key host defense response, is unknown. Although smokers are chronically exposed to LPS through inhaled tobacco smoke, the acute effect of inhaled LPS on ...
Manni M L ML Division of Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, - - 2014
Asthma is a common respiratory disease affecting ∼300 million people worldwide. Airway inflammation is thought to contribute to asthma pathogenesis, but the direct relationship between inflammation and airway hyperresponsiveness (AHR) remains unclear. This study investigates the role of inflammation in a steroid-insensitive, severe allergic airway disease model and in severe ...
Shen Xuejiao X Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Xinkang 46, Ya'an 625014, People's Republic of - - 2014
Examples of probiotics that can promote host health by improving its intestinal microbial balance and intestinal immunity belong to the genus Lactobacillus. Bursin (BS) is a peptide isolated from the bursa of Fabricius for use as an adjuvant for a variety of immunogens. To investigate the synergistic effects of Lactobacillus ...
Verhage R J J RJ Department of Surgery, University Medical Centre Utrecht, Utrecht, The - - 2014
/st>Transthoracic oesophagectomy requires prolonged one-lung ventilation causing systemic and local inflammatory responses. Application of continuous positive airway pressure (CPAP) to the collapsed lung potentially reduces pulmonary damage, hypoxia, and consequent inflammation. This randomized controlled trial studied the influence of CPAP applied to the collapsed right lung during thoracoscopic oesophagectomy on ...
Singh Bisu B Department of Zoology, Balurghat College, Blaurghat, Dakshin Dinajpur, 733101, West Bengal, India; Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri 734013, West Bengal, - - 2014
Over the years, schizophrenia is speculated to be associated with immune or inflammatory reactions mediated by cytokines. It is proposed that chronic inflammation might damage the micro-vascular system of brain and hamper cerebral blood flow. Scientific evidence suggests that an increase of stress hormone like norepinephrine may activate the inflammatory ...
El Bassat Hanan H Department of Tropical Medicine, Faculty of Medicine, Tanta University, Tanta, - - 2014
This study aimed to find out non-invasive markers for the assessment of severity of non-alcoholic steatohepatitis (NASH) in an attempt to decrease the need for liver biopsy. It also aimed to evaluate the key role of apoptosis in the pathogenesis of the disease and the suggested role of anti-apoptotic factors ...
Teymournejad Omid O Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, - - 2014
Outer inflammatory protein A (OipA) has an important role in Helicobacter pylori pathogenesis. In this study, we purified the outer membrane protein and evaluated the effects of this protein on maturation and cytokine production by dendritic cells (DCs). The oipA gene was inserted into pET28a, and this construct was transformed ...
Howe Charles L CL Department of Neurology, Mayo Clinic, Rochester, Minnesota; Department of Immunology, Mayo Clinic, Rochester, - - 2014
Neuromyelitis optica (NMO) is a primary astrocyte disease associated with central nervous system inflammation, demyelination, and tissue injury. Brain lesions are frequently observed in regions enriched in expression of the aquaporin-4 (AQP4) water channel, an antigenic target of the NMO IgG serologic marker. Based on observations of disease reversibility and ...
Caraballo Juline N JN Department of Ophthalmology - - 2014
Abstract Purpose: To compare the cytokine spectrum of vitreoretinal lymphoma to uveitis and correlate cytokine concentrations with disease activity. Methods: Retrospective case series of 10 patients with vitreoretinal lymphoma and 7 patients with uveitis. Aqueous humor concentration of IFN-γ, TNF-α, TNF-β, IL-1ra, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, ...
Astrup Elisabeth E Institute of Clinical Medicine, Akershus University Hospital, Lørenskog, Norway ; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, - - 2014
Scrub typhus, caused by Orientia tsutsugamushi, is endemic in the Asia-Pacific region. Mortality is high if untreated, and even with treatment as high as 10-20%, further knowledge of the immune response during scrub typhus is needed. The current study was aimed at comparing plasma levels of a variety of inflammatory ...
Magalon Jeremy J Culture and Therapy Unit, CHU La Conception (AP-HM) , Marseilles, France - - 2014
Autologous conditioned serum (ACS) is a recent biotherapy based on certain cytokines anti-inflammatory properties mainly used for the reduction of osteoarthritis (OA) symptoms. Here we investigated different physico-chemical factors influencing ACS purification and cytokine production. Human venous blood was incubated in the presence of different diameter beads (respectively 2.5, 3, ...
Darkoh Charles C The University of Texas School of Public Health-Center For Infectious Diseases, Houston, Texas 77030, - - 2014
There are major gaps in our understanding of the immunopathogenesis of C. difficile infections (CDI). In this study, 36 different biomarkers were examined in the stools of CDI and non-CDI patients using the Proteome Profiler Human Cytokine Array assay and quantitative ELISA. CDI diarrheal stools showed higher relative amounts of ...
Caselles Ab A Cell Physiology Research Group, Department of Physiology, University of Extremadura, Caceres, - - 2014
Apoptosis in the testis is required to ensure an efficient spermatogenesis. However, sometimes, defective germ cells that are marked for elimination during this process escape elimination in the testes, giving rise to ejaculates with increased percentages of abnormal and apoptotic spermatozoa and a high percentage of apoptotic bodies. Apoptosis markers ...
Melki Vilyam V Department of Surgical Sciences, Cardiac and Thoracic Surgery, Uppsala University , Uppsala , - - 2014
Objectives. During extracorporeal circulation (ECC), a mechanical pump and an oxygenator replace the functions of the heart and lungs. The aim of this study is to test the effect of the nitric oxide donor glyceryl-tri-nitrate on activation markers of the innate immune system during simulated ECC. Design. Whole blood concentrations ...
Martinez Danica D Inflammation and Infection Research Centre (IIRC), School of Medical - - 2014
In chronic hepatitis C virus infection (CHC), expression of suppressor of cytokine signaling-3 (SOCS3) has been shown to be associated with obesity and non-response to antiviral therapy. In this study, we aimed to determine the effect of SOCS3 induction on the cytokine response in patients receiving Pegylated interferon (PegIFN) and ...
Ciprandi Giorgio G Department of Medicine, IRCCS - Azienda Ospedaliera Universitaria San Martino, Viale Benedetto XV 6, 16132 Genoa, - - 2014
Allergic asthma and rhinitis are characterized by IgE-mediated inflammation consequent to the exposure to a specific allergen. Therefore, IgE production may be considered the hallmark of allergy. Actually, allergen immunotherapy (AIT) is the unique causal treatment for respiratory allergy. Indeed, successful AIT can induce a physiologic immune tolerance toward the ...
Szalat Raphael R Département d'immunologie Clinique, Hôpital Saint Louis, Paris, F-75010, France; EA3963, Université Paris 7 Denis Diderot, INSERM, IFR105, Institut Universitaire d'Hématologie, Paris, F-75475, - - 2014
Xanthomatosis associated with monoclonal gammopathy includes hyperlipidemic xanthoma (HX), normolipidemic xanthoma (NX) and necrobiotic xanthogranuloma (NXG). All three pathologies are characterized by skin or visceral lesions related to cholesterol accumulation, monoclonal immunoglobulin (MIg) and hypocomplementemia. The pathophysiology underlying NXG remains unknown although the involvement of MIg is suspected. To provide ...
Barra Lillian L From the Department of Medicine, Division of Rheumatology, the Department of Microbiology and Immunology, and the Centre for Human Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, - - 2014
Various cytokines have been implicated in the pathogenesis of rheumatoid arthritis (RA) and it is known that elevations in multiple cytokines occur prior to disease onset. The objective of our study is to determine whether the cytokine profile in unaffected first-degree relatives (FDR) of patients with RA is distinct from ...
Miao Yanying Y Department of Medicine, University of Chicago, Section of Cardiology, Chicago, IL 60637, - - 2014
Stroke is a leading cause of death and serious long-term disability. Ischemic stroke is the major subtype of stroke. Currently, its diagnosis is mainly dependent upon clinical symptoms and neuroimaging techniques. Despite these clinical and imaging modalities, often strokes are not recognized after initial onset. As early intervention of medical ...
Mahle William T WT Division of Pediatric Cardiology, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia. Electronic address: - - 2014
Cardiac surgery in infants results in a profound inflammatory response secondary to cardiopulmonary bypass (CPB) and the need for blood products. It is not clear how this inflammatory response modulates postoperative course or whether quantification of proinflammatory cytokines can aid with risk stratification. In this study, we prospectively assessed a ...
Benito María Jesús MJ IOBA - University of Valladolid, Campus Miguel Delibes, Paseo de Belén 17, Valladolid E-47011, Valladolid, - - 2014
Tear levels of certain cytokines/chemokines can potentially serve as biomarkers for dry eye and other ocular surface diseases if they remain stable from day-to-day in healthy eyes. The aim of this study was to determine the normal intra- and inter-day variation of selected tear cytokines/chemokines. Tear samples from 24 young, ...
Bose Madhura M Department of Physiology, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata, 700009, - - 2014
Karanjin, the furanoflavonoid reported to possess gastroprotective and anti-diabetic properties, was investigated against experimental arthritis and its molecular signalling in inflammation was explored in macrophages. Karanjin was isolated from hexane extract of Pongamia pinnata seeds and was evaluated on arthritis markers in adjuvant induced arthritis model (AIA) in two doses ...
Chou Sherry Hsiang-Yi - - 2014
There is growing interest in the potential neuroprotective properties of gelsolin. In particular, plasma-type gelsolin (pGSN) can ameliorate deleterious inflammatory response by scavenging pro-inflammatory signals such as actin and lipopolysaccharide. In a recent issue of Critical Care, Pan and colleagues report an important association between pGSN and subarachnoid hemorrhage (SAH) ...
Dauvilliers Yves Y CHU Montpellier, Service de Neurologie, Unité des Troubles du Sommeil, Hôpital Gui-de-Chauliac, Montpellier, France; National Reference Network for Orphan Diseases (Narcolepsy, Idiopathic Hypersomnia and Kleine Levin syndrome),; Inserm, U1061, F-34000 Montpellier, France; Université Montpellier 1, F-34000 Montpellier, France. Electronic address: - - 2014
Recent advances in the identification of susceptibility genes and environmental exposures provide strong support that narcolepsy-cataplexy is an immune-mediated disease. Only few serum cytokine studies with controversial results were performed in narcolepsy and none in the cerebrospinal fluid. We measured a panel of 12 cytokines by a proteomic approach in ...
Wang Yong-Tang - - 2014
As a new type of biomaterials, gold nanoparticles (GNPs), also known as colloidal gold (CG), have a wide biomedical application. In this study, GNPs with diameters of 10, 15, and 25 nm were prepared by sodium citrate reduction, and detected by common optical property, ultraviolet-visible (UV-vis) absorbance spectroscopy, and scanning ...
Craddock Travis J A TJ Center for Psychological Studies, Nova Southeastern University, Fort Lauderdale, Florida, United States of America ; Graduate School for Computer and Information Sciences, Nova Southeastern University, Fort Lauderdale, Florida, United States of America ; Institute for Neuro-Immune Medicine, Nova Southeastern University, Fort Lauderdale, Florida, United States of - - 2014
A key component in the body's stress response, the hypothalamic-pituitary-adrenal (HPA) axis orchestrates changes across a broad range of major biological systems. Its dysfunction has been associated with numerous chronic diseases including Gulf War Illness (GWI) and chronic fatigue syndrome (CFS). Though tightly coupled with other components of endocrine and ...
Tang Ying Y Department of Respiratory Medicine, The First Hospital, Jilin University, Changchun, - - 2014
Macrophages are the infiltrate components of tuberculous pleural effusion (TPE). This study is aimed at examining the role of different subsets of macrophages in pleural fluid (PF) and peripheral blood (PB) from patients with new onset TPE. The numbers of PB and PF CD163(+), CD206(+) and CD115(+) macrophages in 25 ...
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