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Hartman Hannes H Department of Clinical Sciences Malmö, Section of Surgery, Skåne University Hospital, Lund University, Inga-Marie Nilssons Gata 46, 205 02, Malmö, Sweden, - - 2014
The onset of acute pancreatitis (AP) is characterized by early protease activation followed by inflammation and organ damage, but the mechanisms are poorly understood. We hypothesized that histone deacetylase (HDAC) inhibition might exert protective effects on AP and investigated the role of HDAC in trypsin activation, inflammation, and tissue damage ...
Jaworek Jolanta J Jolanta Jaworek, Department of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Collegium Medicum, 31-125 Kraków, - - 2014
Acute pancreatitis is a nonbacterial disease of the pancreas. The severe form of this ailment is characterized by high mortality. Whether acute pancreatitis develops as the severe type or resolves depends on the intensity of the inflammatory process which is counteracted by the recruitment of innate defense mechanisms. It has ...
Tang Yin - - 2014
In this study, generation 5 (G5) polyamidoamine (PAMAM) dendrimers with two different surface groups, G4.5-COOH and G5-OH, were investigated for their protective effects on pancreas injury in a caerulein-induced acute pancreatitis (AP) mouse model. Both dendrimers significantly decreased pathological changes in the pancreas and reduced the inflammatory infiltration of macrophages ...
Irrera Natasha N Natasha Irrera, Alessandra Bitto, Monica Interdonato, Francesco Squadrito, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, - - 2014
Acute pancreatitis (AP) is an inflammatory disease characterized by acute inflammation and necrosis of the pancreatic parenchyma. AP is often associated with organ failure, sepsis, and high mortality. The pathogenesis of AP is still not well understood. In recent years several papers have highlighted the cellular and molecular events of ...
Yu Changhui C Department of Clinical Sciences, Section of Surgery, Malmö, Lund University, 20502 Malmö, Sweden.; Department of Gastroenterology, Zhujiang Hospital of Southern Medical University, 510282 Guangzhou, - - 2014
Neutrophil recruitment is known to be a rate-limiting step in mediating tissue injury in severe acute pancreatitis (AP). However, the signalling mechanisms controlling inflammation and organ damage in AP remain elusive. Herein, we examined the role of Ras signalling in AP. Male C57BL/6 mice were treated with a Ras inhibitor ...
Guzmán Esther A EA Center for Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University, 5600 US 1 North, Ft. Pierce, FL, 34946, USA, - - 2014
Pancreatic cancer, the 4th leading cause of cancer death in the US, is highly resistant to all current chemotherapies, and its growth is facilitated by chronic inflammation. An important mediator of inflammation is the nuclear factor kappa B (NFκB), a transcription factor that regulates over 500 genes including the regulation ...
Lv Jia Chen - - 2014
Abstract This study investigated the anti-oxidative and anti-inflammtory effects of lycopene on severe acute pancreatitis (SAP) in both in vivo and in vitro models. Utilizing a rat model, we found that lycopene administration protected against SAP, as indicated by the decreased levels of serum amylase and C-reaction protein. Pathological changes ...
Gorskii V A VA N. I. Pirogov Russian National Research Medical University, Moscow, - - 2014
Primary pancreatic injury that occurs in acute pancreatitis leads to necrosis of pancreatic cells and is accompanied by the development systemic inflammatory response of varying severity. Systemic inflammatory response, in turn, can lead to the development of multiple organ dysfunction syndrome and death of patients. The release of damage-associated molecular ...
Cunha Débora Maria Gomes DM Emergency Medicine Department, University of Sao Paulo, Sao Paulo, - - 2014
Acute pancreatitis is a life-threatening situation, frequently associated with uncontrolled local and systemic inflammation, and aging is associated with a worst prognosis. Antimicrobial peptides are ancient molecules that belong to innate immunity, produced by epithelial and immune cells, and are able to trigger a myriad of effector responses. We have ...
Akinosoglou Karolina K Karolina Akinosoglou, Charalambos Gogos, Department of Internal Medicine and Infectious Diseases, University General Hospital of Patras, 26504 Rio, - - 2014
Acute pancreatitis (AP) is one of the most common diseases of the gastrointestinal tract, bearing significant morbidity and mortality worldwide. Current treatment of AP remains unspecific and supportive and is mainly targeted to aggressively prevent systemic complications and organ failure by intensive care. As acute pancreatitis shares an indistinguishable profile ...
Lupia Enrico E Enrico Lupia, Luca Pigozzi, Giuseppe Montrucchio, Department of Medical Sciences, University of Torino, 10126 Torino, - - 2014
A large body of experimental and clinical data supports the notion that inflammation in acute pancreatitis has a crucial role in the pathogenesis of local and systemic damage and is a major determinant of clinical severity. Thus, research has recently focused on molecules that can regulate the inflammatory processes, such ...
Liou Geou-Yarh GY Department of Cancer Biology, Mayo - - 2014
Desmoplasia and an inflammatory environment are defining features of pancreatic cancer. Unclear is how pancreatic cells that undergo oncogenic transformation can crosstalk with immune cells and how this contributes to the development of pancreatic lesions. Here we demonstrate that pancreatic acinar cells expressing mutant Kras can expedite their transformation to ...
Prada Jiménez de Cisneros Joaquín J Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow G61 1QH, UK - - 2014
Gastrointestinal nematodes are a global cause of disease and death in humans, wildlife and livestock. Livestock infection has historically been controlled with anthelmintic drugs, but the development of resistance means that alternative controls are needed. The most promising alternatives are vaccination, nutritional supplementation and selective breeding, all of which act ...
Zhou Min M Department of General Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, - - 2014
MicroRNAs (miRNAs) are aberrant in many human tumors which can be transferred to immune cells by tumor-derived exosomes. Dendritic cells (DCs) play an important role in activation of immune response. However, the effect of tumor-derived exosomes on toll-like receptor (TLR) in DCs remains unclear. We investigated the influence of pancreatic ...
Liu Dian-Lei DL Department of General Surgery, Guangxing Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310007, P.R. - - 2014
Gemcitabine is a first‑line chemotherapeutic agent used in the treatment of pancreatic cancer; however resistance of the disease to the drug often develops over time. Agents that can either enhance the effects of gemcitabine, or help to overcome the chemoresistance to the drug are needed for the successful treatment of ...
Bhoopathi Praveen P Human and Molecular Genetics, Virginia Commonwealth - - 2014
Polyinosine-polycytidylic acid (pIC) is a synthetic dsRNA that acts as an immune agonist of TLR3 and RLR to activate dendritic and NK cells that can kill tumor cells. pIC can also trigger apoptosis in pancreatic ductal adenocarcinoma cells but its mechanism of action is obscure. In this study, we investigated ...
Okazaki Kazuichi K Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Osaka, - - 2014
Recent studies have proposed nomenclatures of type 1 autoimmune pancreatitis (AIP) (IgG4-related pancreatitis), IgG4-related sclerosing cholangitis (IgG4-SC), IgG4-related cholecystitis, and IgG4-related hepatopathy as IgG4-related disease (IgG4-RD) in the hepato-bilio-pancreatic system. In IgG4-related hepatopathy, a novel concept of IgG4-related autoimmune hepatitis (AIH) with the same histopathological features as AIH has been ...
Suzuki Rei R Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, - - 2014
Although 5-fluorouracil (5-FU)-based combination chemotherapy (i.e. FOLFIRINOX) has demonstrated effectiveness against pancreatic cancer, novel therapeutic strategies must be developed to increase the therapeutic window of these cytotoxic agents. Genistein is a soy-derived isoflavone with pleiotropic biological effects that can enhance the antitumor effect of chemotherapeutic agents. To understand how genistein ...
Qin Yong Y Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. - - 2014
We previously demonstrated that resveratrol (Res) regulates the expression of PKC α and δ, to eventually inhibit growth and induce apoptosis in human gastric cancer cells. In the present study, the effect of Res on the growth of human pancreatic cancer cells was investigated, to further unveil the underlying mechanism. The ...
Sexton Michelle M Center for the Study of Cannabis and Social Policy, Seattle, WA, 98028, USA, - - 2014
Cannabinoids affect immune responses in ways that may be beneficial for autoimmune diseases. We sought to determine whether chronic Cannabis use differentially modulates a select number of immune parameters in healthy controls and individuals with multiple sclerosis (MS cases). Subjects were enrolled and consented to a single blood draw, matched ...
White Amelia G AG Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, 1008 W Hazelwood Drive, Urbana, IL, 61802, - - 2014
Bacterial skin infections are common in dogs and humans. Keratinocytes have phenotypic features of nonprofessional antigen-presenting cells and express various cytokines. However, little is known about the effects of antibiotics on inflammatory markers in canine keratinocytes. To investigate inflammatory markers in canine progenitor epidermal keratinocytes (CPEKs) and to determine the ...
Cheng Dan D Tongji Hospital, Wuhan, China ; - - 2014
Rationale: Activation of type 2 cytokine pathways plays a central role in a large subset of subjects with asthma. "Th2 high" and "Th2 low" asthma have distinct clinical, pathological and molecular phenotypes and respond differently to therapy. The factors that initiate type 2 responses in some subjects with asthma are ...
Trenova Anastasiya G AG Department of Neurology, University Hospital "St. George", Bulgaria. Electronic address: - - 2014
T-helper (Th) cells involved in the pathogenesis of multiple sclerosis (MS) represent a functionally heterogeneous population defined by their cytokine secretion profile. The effects of immunotherapeutic drugs on the cytokine network are still not fully clarified. This study aimed to investigate serum levels of IFN-γ, TNF-α, IL-4, IL-10 in interferon-β-1b-treated ...
Abdallah Marwa M Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, - - 2014
Not only macrophages, T-helper(Th)1 and Th2, but also CD4(+) CD25(high) FoxP3(+) regulatory T-cells(T-regs), are involved in immune response to Mycobacterium leprae. to evaluate serum interleukin(IL)-1β and IL-12p70(macrophage cytokines), interferon-γ(IFN-γ)(Th1 cytokine), IL-4(Th2 cytokine), and circulating CD4(+) CD25(high) FoxP3(+) T-regs, in untreated leprosy patients. 43 patients and 40 controls were assessed for ...
Reuken Philipp A PA Department of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Friedrich Schiller University, Jena, Germany; Integrated Research and Treatment Center - Center for Sepsis Control and Care (CSCC), Jena University Hospital, Friedrich Schiller University Jena, - - 2014
Systemic inflammation in advanced cirrhosis represents a spectrum ranging from subclinical pathological bacterial translocation and immune activation to overt bacterial infection and sepsis. We hypothesized that systemic inflammation in cirrhosis is accompanied by a failure of ADAMTS13 to control the prothrombotic function of Von Willebrand factor (VWF), which is increased ...
Bolkun L L Department of Haematology, Medical University of Bialystok, 24a Sklodowskiej-Curie, Bialystok, 15-276, Poland, - - 2014
B cell-activating factor (BAFF), a proliferation-inducing ligand (APRIL) and apoptosis-inducing ligand (TRAIL) were demonstrated in several haematological diseases including acute myeloid leukemia (AML). Those cytokines are capable of activating a broad spectrum of intracellular signalling cascades that can either induce apoptosis or protect from programmed cell death. We have analysed ...
Tang Qunyong Q College of Food Science and Technology, Key Laboratory of Food Processing and Quality Control, Ministry of Agriculture of China, Nanjing Agricultural University, Nanjing, P. R. - - 2014
The lipopeptide antibiotic fengycin, produced by Bacillus subtilis, strongly inhibits growth of filamentous fungi. In this study, we evaluated the effects of fengycin treatment on apoptosis and necrosis in Rhizopus stolonifer by means of cell staining and epifluorescence microscopy. At fengycin concentrations less than 50 μg/ml, treated fungal cells demonstrated ...
Maté Ianire I Department of Physiology (Animal Physiology II), Faculty of Biology, Complutense University of Madrid (UCM), Madrid, - - 2014
The aging process involves the impairment of the immune system (immunosenescence), based on the imbalance of the redox status, as occurs in neurodegenerative diseases such as Alzheimer's disease (AD). Since in AD there is a systemic disorder, we aimed to assess longitudinally, from before the onset until the complete establishment ...
Wolak Talya T Hypertension Unit Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel. Electronic address: - - 2014
Atherosclerosis is a chronic inflammatory process of the vessel wall with systemic correlates. It is now well established that patients' outcome is tightly linked to atherosclerotic plaque stability, potentially more so than to the mere plaque size. Osteopontin (OPN) is an integrin-binding ligand, N-linked glycoprotein, which was recognized as a ...
Caruntu Constantin C Dermatology Research Laboratory, "Carol Davila" University of Medicine & Pharmacy, 22-24 Gr. Manolescu, 0111234, Sector 1, Bucharest, - - 2014
The immune-pathogenesis of psoriatic arthritis represents a subject of intense research, as a still unknown factor can trigger the chronic inflammation that, upon a defective immune terrain, generates this auto-immune/auto-inflammatory condition. The pathogenesis complexity of psoriatic arthritis resides in the psoriatic synovitis milieu, where intricate immune relations are emerging during ...
Garutti Ignacio I From the *Anesthesiology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain; †Department of Biochemistry and Molecular Biology III, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain; and ‡Thoracic Surgery Department, Hospital General Universitario Gregorio Marañón, Madrid, - - 2014
Lung resection surgery is associated with an inflammatory reaction. The use of 1-lung ventilation (OLV) seems to increase the likelihood of this reaction. Different prophylactic and therapeutic measures have been investigated to prevent lung injury secondary to OLV. Lidocaine, a commonly used local anesthetic drug, has anti-inflammatory activity. Our main ...
Teichert Tom T Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf׳m Hennekamp 65, 40225 Düsseldorf, Germany. Electronic address: - - 2014
Exposure to air pollutants represents a risk factor not only for respiratory diseases and lung cancer, but also for cardiometabolic diseases. It has been hypothesised that local inflammation in the lung and systemic subclinical inflammation are linked by impaired lung function and the spill-over of proinflammatory factors from the lung ...
Mesman Esther E Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The - - 2014
There is increasing evidence that both immune and neurochemical alterations are involved in the pathogenesis of bipolar disorder; however, their precise role remains unclear. In this study, we aimed to evaluate neuro-immune changes in a prospective study on children of patients with bipolar disorder. Bipolar offspring, from the prospective Dutch ...
Zingone Adriana A Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, - - 2014
Currently, no reliable biomarkers are available to predict transformation from smoldering myeloma (SMM) to multiple myeloma (MM). Using an ultrasensitive enzyme-linked immunosorbent assay (ELISA) we assessed the levels of a broad range of cytokines and chemokines in the peripheral blood (PB) and bone marrow (BM) supernatant collected from 14 SMM ...
Crescio Claudia C Dipartimento di Scienze Biomediche, Università degli studi di Sassari, 07100 Sassari, - - 2014
Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and ...
Attia E A S EA Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Ain Shams University, Cairo, 11381, Egypt, - - 2014
Leprosy is not only a bacteriological disease but also an immunological disease, in which T helper17 and CD4(+) CD25(high)FoxP3(+) regulatory T cells (T-regs), among others, may play a role. We aimed to evaluate serum levels of interleukin (IL)-17, IL-22 (Th17 cytokines), IL-10 and transforming growth factor (TGF)-β (down regulatory cytokines) ...
Chowdhury Imran Hussain IH Department of Biochemistry, Institute of Postgraduate Medical Education and Research (IPGME&R), 244B, AJC Bose Road, Kolkata 700020, - - 2014
Active pulmonary tuberculosis (APTB) is associated with a failure of the host immune system to control the invading Mycobacterium tuberculosis (Mtb). The objective of this study was to quantify and assess the role of serum inflammatory cytokines in active pulmonary tuberculosis patients following anti-tuberculosis drug (ATD) therapy. Blood samples were ...
Calder Philip C PC Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom. - - 2014
In order to gain better insight into meaningful effects of nutrition on immune function, there is a need for guidance on the assessment and interpretation of immune markers. However, there is no consensus as to which markers best represent the various aspects of immunity, including acute, chronic or low-grade inflammation. ...
Cabrera Carmen M CM Immunology Section, Servicio de Análisis Clínicos, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain. Electronic address: - - 2014
Systemic reactions to Hymenoptera stings can be fatal and represent a reduction in the quality of life. The immune mechanisms involved in venom allergic subjects are barely known. Nevertheless, a shift towards a Th1-type response with an increase in IFNγ levels has been observed after venom immunotherapy (VIT). There is ...
Palmer Christine D CD aRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Cambridge bFenway Healthand Department of Medicine, Beth Israel Deaconess Hospital/Harvard Medical School, Boston cDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA dHeinrich-Pette-Institut, Leibniz Institute for Experimental Virology, Department of Viral Immunology, Hamburg, - - 2014
This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4/CD8 T cell ratios. ...
Neupane Sudan P SP SERAF-Norwegian Centre for Addiction Research, University of Oslo, Oslo, - - 2014
As major depression (MD) is often comorbid with alcohol-use disorders (AUD) and alcohol itself modulates the immune system, we examined serum levels of interleukin (IL)-6, IL-10, tumor necrosis factor (TNF), and interferon (IFN)-γ in AUD patients with and without MD. Putative interactions between alcohol variables and MD on cytokine levels ...
de-la-Torre Alejandra A Universidad del Rosario, Escuela de Medicina y Ciencias de la Salud, Departamento de Inmunología, Bogotá, - - 2014
To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed ...
Fink S L SL Department of Laboratory Medicine, Yale School of Medicine , New Haven, CT , - - 2014
Context. Cardiac glycosides of plant origin are implicated in toxic ingestions that may result in hospitalization and are potentially lethal. The utility of commonly available digoxin serum assays for detecting foxglove and oleander ingestion has been demonstrated, but no studies have evaluated the structurally similar convallatoxin found in Convallaria majalis ...
Lippi Giuseppe G Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma , Parma , - - 2014
Several lines of evidence demonstrate that the immune system plays a pivotal role in development and progression of ischemic heart disease (IHD). More recently, a series of biological and clinical investigations has generated new interest about the existence of a relationship between a specific class of immunoglobulin, that is immunoglobulin ...
Ruffilli I I Department of Clinical and Experimental Medicine, University of Pisa, Pisa, - - 2014
The interferon-γ-inducible protein 10 (IP-10) was initially identified as a chemokine that is induced by interferon (IFN)-γ. IP-10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3). IP-10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type ...
Park Mi Hwa MH Department of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 617-736, - - 2014
This study investigated whether Padina arborescens extract (PAE) protects INS-1 pancreatic β cells against glucotoxicity-induced apoptosis. Assays, including cell viability, lipid peroxidation, generation of intracellular ROS, NO production, antioxidant enzyme activity and insulin secretion, were conducted. The expressions of Bax, Bcl-2, and caspase-3 proteins in INS-1 cells were evaluated by ...
Moreno-Solís G G Pediatric Pneumology and Allergy Unit, Pediatrics Clinical Management Unit, Reina Sofía Children's University Hospital, Avda. Menéndez Pidal s/n, 14004 Córdoba, Spain; Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, - - 2014
Respiratory syncytial virus acute bronchiolitis (RSV-AB) is a major cause of hospital admission among our infants. The immune and inflammatory mechanisms involved in the RSV-AB and factors influencing severity have not been clearly established, although an imbalanced Th1 and Th2 response seems to be crucial. To assess the local and ...
Gono Takahisa T Institute of Rheumatology, Tokyo Women's Medical University and Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, - - 2014
PM and DM are often complicated by interstitial lung disease (ILD). In this study we aimed to evaluate various serum cytokines in patients with PM/DM with ILD so as to clarify the differences in pathophysiology between anti-melanoma differentiation-associated gene 5 antibody-associated ILD (anti-MDA5-ILD) and anti-aminoacyl tRNA synthetase antibody-associated ILD (anti-ARS-ILD). ...
Clark K Fraser KF AVC Lobster Science Centre, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada. C1A 4P3; Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada. C1A 4P3; Department of Plant and Animal Sciences, Faculty of Agriculture, Dalhousie University, Truro, Nova Scotia, B2N 5E3. Electronic address: - - 2014
The American lobster (Homarus americanus) is the most important commercially exploited marine species in Canada. Very little is known about the H. americanus molecular humoral immune response or how to determine if a seemingly healthy lobster is infected with a pathogen. The goal of this work is to characterize several ...
Raeiszadeh Jahromi Sareh S Genetics and Genomics Lab, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore, Karnataka, - - 2014
Abstract Objectives: The development of inflammation in asthma involves an intricate network of cytokines that recruit and activate numerous immune cells. This study was aimed to compare serum levels of IL-10, IL-17F, and IL-33 in asthmatic patients and non-asthmatic controls and correlate cytokine levels to asthma severity and various clinical, ...
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