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Alani Behrang B Department of Genetic and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, - - 2014
By the current study, we tried to find out the interactive mechanisms enrolled by Hsp70 and Hsp90 following the 6-hydroxydopamine (6-OHDA)-induced oxidative stress. Of heat shock protein (Hsp) family, we have previously evaluated the effects of Hsp90 gene silencing on in vitro model of Parkinson's disease and its influence on ...
Kim Jung Soo JS Department of Neurosurgery, Haeundae Paik Hospital, College of Medicine, Inje University, Busan, Republic of - - 2014
Kainic acid (KA)-induced neuronal death is closely linked to endoplasmic reticulum (ER) and mitochondrial dysfunction. Parkin is an ubiquitin E3 ligase that mediates the ubiquitination of the Bcl-2 family of proteins and its mutations are associated with neuronal apoptosis in neurodegenerative diseases. We investigated the effect of salubrinal, an ER ...
Hu Xiaolei X Department of Endocrinology, Shanghai 3rd People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201999, P.R. - - 2014
Ubiquitin-fold modifier 1 (Ufm1) is a new member of the ubiquitin-like protein family, and its biological function remains largely unknown, particularly in macrophages. In this study, we demonstrate that Ufm1 expression is increased in diabetic mouse resident peritoneal macrophages (RPMs) and in the mouse macrophage cell line, Raw264.7, subjected to endoplasmic reticulum (ER) ...
Ha Jung-Heun JH Department of Food Science and Human Nutrition, - - 2014
Inflammation and endoplasmic reticulum (ER) stress are common denominators for vision-threatening diseases such as diabetic retinopathy and age-related macular degeneration. Based on our previous study, supplementation with muscadine grape polyphenols (MGPs) alleviated systemic insulin resistance and proinflammatory responses. In this study, we hypothesized that MGPs would also be effective in ...
Yi B B Hospital of the University of Munich (LMU), Marchioninistrasse 15, 81377 Munich, - - 2014
During interplanetary exploration, chronic stress caused by long term isolation and confinement in the spacecraft is one of the major concerns of physical and psychological health of space travelers. And for human on Earth, more and more people live in an isolated condition, which has become a common social problem ...
Li Meiling M Department of Cell Biology and Genetics, Core Facility of Development Biology, Chongqing Medical University, Chongqing 400016, - - 2014
Progranulin (PGRN) was reported to be a stress-response factor in response to hypoxia and acidosis. Here we present evidences demonstrating that PGRN is also an endoplasmic reticulum(ER) stress responsive factor: PGRN expression was induced and its activation of Erk1/2 and Akt signaling enhanced in response to ER stress; Normal ER ...
Adamo Shelley A SA Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS B3H 4R2, - - 2014
Intense, short-term stress (i.e., robust activation of the fight-or-flight response) typically produces a transient decline in resistance to disease in animals across phyla. Chemical mediators of the stress response (e.g., stress hormones) help induce this decline, suggesting that this transient immunosuppression is an evolved response. However, determining the function of ...
Bellezza Ilaria I Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica Cellulare, Università di Perugia, Via del Giochetto, 06123, Perugia, Italia. Electronic address: - - 2014
Many neurological and neurodegenerative diseases are associated with oxidative stress and glial inflammation, all related to endoplasmic reticulum stress. Cyclo(His-Pro) is an endogenous cyclic dipeptide that exerts cytoprotection by interfering with the Nrf2-NF-κB systems, the former presiding the antioxidant and the latter the pro-inflammatory cellular response. Here we investigated whether ...
Batal Ibrahim I *Transplantation Research Center, Departments of †Pathology and ‡Dermatology, and §Renal Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, - - 2014
Whereas DC have increasingly been recognized for their role in activating the inflammatory cascades during IRIs, the mechanisms by which oxidative stress enhances DC activation remain to be explored. We examined the role of oxidative stress on two important features of DC: T cell activation and trafficking. Bone marrow-derived OS-DC ...
Zhou Shanshan S The Center of Cardiovascular Diseases at the First Hospital of Jilin University, Changchun, 130021, China; KCHRI at the Department of Pediatrics, University of Louisville, Louisville, 40202, - - 2014
Endoplasmic reticulum (ER) stress, an adaptive response normally, causes apoptotic cell death under pathological conditions. Cardiac ER stress and associated cell death involve in the inflammatory responses that often cause cardiac remodeling and dysfunction. Here we examined whether chronic intermittent hypoxia (IH) induces cardiac ER stress and associate cell death ...
Kwak-Kim Joanne J Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA; Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, - - 2014
Inflammatory immune response plays a key role in reproductive failures such as multiple implantation failures (MIF), early pregnancy loss, and recurrent pregnancy losses (RPL). Cellular immune responses particularly mediated by natural killer (NK), and T cells are often dysregulated in these conditions. Excessive or inappropriate recruitment of peripheral blood NK ...
St Juliana Justin R JR Department of Biology, Indiana State University, Terre Haute, USA; Mitrani Department of Desert Ecology, Swiss Institute for Dryland Environmental and Energy Research, Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion, Israel; Department of Life and Physical Science, Ivy Tech Community College Region 7, Terre Haute, Indiana, - - 2014
1. Parasites are thought to have numerous negative effects on their hosts. These negative effects may be associated with stress in a host. 2. We evaluated the effects of four species of flea ectoparasites (Parapulex chephrenis, Synosternus cleopatrae, Xenopsylla conformis and Xenopsylla ramesis) on non-specific responses of eight species of ...
Wang Zhen Z Key Laboratory of Animal Epidemiology and Zoonosis of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China; Animal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, - - 2014
Brucella melitensis is a facultative intracellular pathogen that mainly resides within macrophages. The mechanisms employed by Brucella to adapt to harsh intracellular environments and survive within host macrophages are not clearly understood. Here, we constructed a cspA gene deletion mutant, NIΔcspA, that did not exhibit any discernible growth defect at ...
B'chir Wafa W INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France; Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, - - 2014
CHOP encodes an ubiquitous transcription factor that is one of the most important components in the network of stress-inducible transcription. In particular, this factor is known to mediate cell death in response to stress. The focus of this work is to study its pivotal role in the control of cell ...
Wang Hui H Guangdong Provincial Key Laboratory of Biotechnology Candidate Drug Research, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, P.R. - - 2014
Oridonin exhibits a curative effect on liver carcinoma in patients and experimental animals. In the present study, we performed proteomic and functional analyses to explore the mechanism involved in the anticancer activity of oridonin. Oridonin treatment for 24 h resulted in a dose-dependent decrease in cell viability with an IC50 value ...
Vargas-Caraveo Alejandra A Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Guillermo Massieu Helguera, No. 239, Fraccionamiento "La Escalera", Ticomán, C.P. 07320 México DF, Mexico; Departamento de Ciencias Químico Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo envolvente Pronaf y Estocolmo s/n, 32310 Cd. Juárez, Mexico. Electronic address: - - 2014
Psychological stress is a condition that not only generates behavioral disorders but also disrupts homeostasis and immune activity that can exacerbate or lead to inflammatory diseases. The aim of this work was to study biochemical changes in circulating immune cells from rats under psychological stress by using vibrational spectroscopy. A ...
Kermani Hamed Reihani HR Departments of Neurosurgery - - 2014
Object The purpose of this study was to evaluate the effects of chronic unpredictable stress on the intervertebral discs of rats. Methods The cellular events involved in injury- and stress-induced disc degeneration were investigated in male Wistar rats. Disc degeneration and apoptosis were evaluated using microscopic (light and electron) and ...
Oliveira Thiago Acosta TA Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Campus Universitário - Camobi, CEP 97105-900 Santa Maria, RS, - - 2014
Living animals exploit information released from dead animals to conduct adaptive biological responses. For instance, a recently published study has shown that avoidance behavior is triggered by death-associated odors in zebrafish. Stress can clearly act as an adaptive response that allows an organism to deal with an imminent threat. However, ...
Suliman Hagir B - - 2014
The influence of mitochondrial dysfunction on pathological states involving inflammatory and/or oxidative stress in tissues that do not show frank cellular apoptosis or necrosis has been rather difficult to unravel, and the literature is replete with contradictory information. Although such discrepancies have many potential causes related to the type of ...
Li Wei-Hong WH Department of Pathophysiology, Chinese PLA General Hospital, Beijing, China; Department of Pathophysiology, College of Basic Medical Sciences, Taishan Medical University, Taian, China; State Key Laboratory of Kidney Disease, (Chinese PLA General Hospital, 2011DAV00088), Beijing, - - 2014
The present study was designed to evaluate whether exogenous calreticulin (CRT) was beneficial for alleviating microwave radiation (MR)-induced injury by suppressing endoplasmic reticulum (ER) stress in rat myocardial microvascular endothelial cells (MMECs). MMECs were pretreated with CRT (25 pg/mL) for 12 h, followed by the exposure to 2.856 GHz radiation ...
Runkel Eva Diana ED Faculty of Biology, Institute of Biology III; BIOSS Centre for Biological Signalling Studies; Spemann Graduate School of Biology and - - 2014
Mitochondria are vital organelles of the aerobic eukaryotic cell. Their dysfunction associates with aging and widespread age-related diseases. To sustain mitochondrial integrity, the cell executes a distinct set of stress-induced protective responses. The mitochondrial unfolded protein response (UPR(mt)) is a first response of the cell to mitochondrial damage. The transcription ...
Zhang Hangjun H Department of Environmental Sciences, Hangzhou Normal University, Xuelin Road 16#, Xiasha Gaojiao Dongqu, Hangzhou, Zhejiang Province 310036, China. Electronic address: - - 2014
Microcystins (MCs) are secondary metabolites produced by cyanobacteria. Oxidative stress is considered the major cytotoxic mechanism of microcystin-LR (MCLR). Quercetin (QE) is a flavonoid that can eliminate reactive oxygen species (ROS) and elicit anti-inflammatory and anti-apoptotic effects. This study determined the regulatory effect of QE on the cytotoxicity and oxidative ...
Vitlic Ana A School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, England, - - 2014
The immune response is essential for keeping an organism healthy and for defending it from different types of pathogens. It is a complex system that consists of a large number of components performing different functions. The adequate and controlled interaction between these components is necessary for a robust and strong ...
Gioacchini Giorgia G 1 Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche , Ancona, Italy - - 2014
Abstract In this study, the effects of probiotic administration on zebrafish Danio rerio intestinal innate immunity and hepatic stress were evaluated. Zebrafish adults were treated for 10 days with the probiotic Lactobacillus rhamnosus IMC 501(®). To assess the effects at the molecular level, the mRNA levels of genes involved in ...
Zhang Xue-Qun XQ Xue-Qun Zhang, Cheng-Fu Xu, Chao-Hui Yu, Wei-Xing Chen, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, - - 2014
Nonalcoholic fatty liver disease (NAFLD) has emerged as a common public health problem in recent decades. However, the underlying mechanisms leading to the development of NAFLD are not fully understood. The endoplasmic reticulum (ER) stress response has recently been proposed to play a crucial role in both the development of ...
Wu Wei W Department of Gastroenterology, The Shanghai Tenth People's Hospital of Tongji University, , Shanghai, - - 2014
The dysfunction of immune regulation plays a critical role in the pathogenesis of a number of chronic inflammatory disorders, such as IBD. A close relationship between psychological stress and intestinal inflammation has been noted; the underlying mechanism remains elusive. This study aims to elucidate a pathological pathway between psychological stress ...
Baker Michael J MJ Institute for Genetics Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) Center for Molecular Medicine (CMMC) University of Cologne, Cologne, - - 2014
The dynamic network of mitochondria fragments under stress allowing the segregation of damaged mitochondria and, in case of persistent damage, their selective removal by mitophagy. Mitochondrial fragmentation upon depolarisation of mitochondria is brought about by the degradation of central components of the mitochondrial fusion machinery. The OMA1 peptidase mediates the ...
Pillai Smitha S Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Duebendorf, - - 2014
Understanding mechanistic and cellular events underlying a toxicological outcome allows the prediction of impact of environmental stressors to organisms living in different habitats. A systems-based approach aids in characterizing molecular events, and thereby the cellular pathways that have been perturbed. However, mapping only adverse outcomes of a toxicant falls short ...
Yun Jeanho J Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA; Department of Biochemistry and Mitochondria Hub Regulation Center, College of Medicine, Dong-A University, Busan 602-714, South - - 2014
For many years, mitochondria were viewed as semiautonomous organelles, required only for cellular energetics. This view has been largely supplanted by the concept that mitochondria are fully integrated into the cell and that mitochondrial stresses rapidly activate cytosolic signaling pathways that ultimately alter nuclear gene expression. Remarkably, this coordinated response ...
Miousse Isabelle R IR Department of Environmental and Occupational Health, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, - - 2014
Respiratory mortality and morbidity has been associated with exposure to particulate matter (PM). Experimental evidence suggests involvement of cytotoxicity, oxidative stress, and inflammation in the development of PM-associated pathological states; however, the exact mechanisms remain unclear. In the current study, we analyzed short-term epigenetic response to PM10 (particles with aerodynamic ...
Sahni Sumit S University of Sydney, - - 2014
N-myc downstream regulated gene 1 (NDRG1) is a potent metastasis suppressor with an undefined role in the stress response. Autophagy is a pro-survival pathway and can be regulated via the PERK/eIF2α-mediated endoplasmic reticulum (ER) stress pathway. Hence, we investigated the role of NDRG1 in stress-induced autophagy as a mechanism of ...
Voraphani N N 1] University of Pittsburgh Asthma Institute at UPMC and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA [2] Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, - - 2014
Severe refractory asthma is associated with enhanced nitrative stress. To determine the mechanisms for high nitrative stress in human severe asthma (SA), 3-nitrotyrosine (3NT) was compared with Th1 and Th2 cytokine expression. In SA, high 3NT levels were associated with high interferon (IFN)-γ and low interleukin (IL)-13 expression, both of ...
Afrazi Amin A Children's Hospital of Pittsburgh, United - - 2014
The cellular cues that regulate the apoptosis of intestinal stem cells (ISCs) remain incompletely understood, yet may play a role in diseases characterized by ISC loss including necrotizing enterocolitis (NEC). Toll-like receptor-4 (TLR4) was recently found to be expressed on ISCs, where its activation leads to ISC apoptosis through mechanisms ...
Arai Koji Y KY Scleroprotein Research Institute, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, - - 2014
Repeated mechanical stresses applied to the same region of the skin are thought to induce morphological changes known as wrinkle. However, the underlying mechanisms are not fully understood. To study the mechanisms, we examined effects of repeated mechanical stress on the dermal equivalent. We developed a novel device to apply ...
Dassati Sarah S Department of Neurological Rehabilitation, Private Hospital "Villa Melitta", Bolzano, - - 2014
Apolipoprotein D (ApoD) is an ancient member of the lipocalin family with a high degree of sequence conservation from insects to mammals. It is not structurally related to other major apolipoproteins and has been known as a small, soluble carrier protein of lipophilic molecules that is mostly expressed in neurons ...
Yan Long - - 2014
A large number of studies have focused on how individual organism responses to a stress condition, but little attention was paid to the stress recovery process especially to ER (endoplasmic reticulum) stress recovery. HERP was originally identified as a chaperone-like protein that is strongly induced upon ER stress. Here we ...
Chen Rui - - 2014
Zinc oxide nanoparticles (ZnO NPs) have been widely used in cosmetics and sunscreens, advanced textiles, self-charging and electronic devices, the potential for human exposure and the health impact at each stage of their manufacture and use is attracting great concerns. In addition to pulmonary damage, nanoparticle exposure is also strongly ...
Navarro-Yepes Juliana J University of Nebraska-Lincoln, School of Veterinary Medicine and Biomedical Sciences, Lincoln, Nebraska, United States, CINVESTAV, IPN, Department of Toxicology, Mexico City, D.F., Mexico ; - - 2014
Significance: The molecular machinery regulating autophagy has started to become elucidated, and a number of studies have undertaken the task to determine the role of autophagy in cell fate determination within the context of human disease progression. Oxidative stress and redox signaling are also largely involved in the etiology of ...
Martin Jessica L JL Department of Biochemistry & Molecular Biology, Oregon Health & Science University, Portland, Oregon, United States of - - 2014
The ability of Leishmania to survive in their insect or mammalian host is dependent upon an ability to sense and adapt to changes in the microenvironment. However, little is known about the molecular mechanisms underlying the parasite response to environmental changes, such as nutrient availability. To elucidate nutrient stress response ...
Shenderov Kevin K Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD - - 2014
The accumulation of improperly folded proteins within the endoplasmic reticulum (ER) generates perturbations known as ER stress that engage the unfolded protein response. ER stress is involved in many inflammatory pathologies that are also associated with the production of the proinflammatory cytokine IL-1β. In this study, we demonstrate that macrophages ...
Oguro Ami A Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, Sanda, - - 2014
NADPH-P450 reductase (NPR) was previously found to contribute to the hypoxic response of cells, but the mechanism was not clarified. In this study, we identified a cellular stress response (CSR) as a new factor interacting with NPR by a yeast two-hybrid system. Overexpression of CSR enhanced the induction of erythropoietin ...
Vida Carmen - - 2014
According to the oxidation-inflammation theory of aging, chronic oxidative stress and inflammatory stress situations (with higher levels of oxidant and inflammatory compounds and lower antioxidant and anti-inflammatory defences) are the basis of the age-related impairment of organism functions, including those of the nervous and immune systems, as well as of ...
Cao Gang G Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, Shanghai, China - - 2014
Chronic stress has dramatic impacts on the immune system and consequently contributes to the onset and progression of a variety of diseases, including cancer, immune disorders, and infections. Recent studies in animals and humans have demonstrated that mesenchymal stem cells (MSCs) significantly modulate the immune system. Here we show that ...
Wink Steven - - 2014
Over the past decade major leaps forward have been made on the mechanistic understanding and identification of adaptive stress response landscapes underlying toxic insult using transcriptomics approaches. However for predictive purposes of adverse outcome several major limitations in these approaches exist. Firstly the limited number of samples that can be ...
Li Bei B Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; Institute of Integrated Traditional Chinese and Western Medicine, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, - - 2014
Evidence shows that psychosocial stress exacerbates asthma, but there is little intervention to alleviate negative effects of psychosocial stress on asthma. We investigated the role of icariin in anti-inflammation and anti-anxiety potential in a murine model combined psychosocial stress with allergic exposure. The results indicated that icariin administered remarkable increased ...
Paniagua Soriano Guillem G LIC, Bio-organic synthesis, Einsteinweg 55, Leiden, Netherlands, 2333 CC ; - - 2014
Significance: Proteasome inhibitors are used in the clinic for treatment of hematopoietic malignancies. PI inhibitors induce endoplasmatic reticulum stress and oxidative stress, disruption of signaling pathways, mitochondrial dysfunction and eventually cell death by apoptosis. PIs designated as clinical candidates include natural product derivatives and compounds developed by rational design and ...
Nakajima Ai A Department of Pharmacology, School of Medicine, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142-8555, - - 2014
Anesthetic treatment has been associated with widespread apoptotic neurodegeneration in the neonatal rodent brain. It has recently been suggested that propofol, a short-acting intravenous anesthetic agent, may have a potential as a neuroprotective agent. An apoptotic pathway mediated through endoplasmic reticulum (ER) stress has been attracting attention. ER stress is ...
Veru Franz F Department of Psychiatry, McGill University, Montreal, QC, - - 2014
Abstract The intra-uterine environment provides the first regulatory connection for the developing fetus and shapes its physiological responses in preparation for postnatal life. Psychological stress acts as a programming determinant by setting functional parameters to abnormal levels, thus inducing postnatal maladaptation. The effects of prenatal maternal stress (PNMS) on the ...
Cano Marisol M Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD - - 2014
How cells degenerate from oxidative stress in aging-related disease is incompletely understood. The study's intent was to identify key cytoprotective pathways activated by oxidative stress, and determine the extent of their protection. Using an unbiased strategy with microarray analysis, retinal pigmented epithelial (RPE) cells treated with cigarette smoke extract (CSE) ...
Gárate Iciar - - 2014
The innate immune response is the first line of defence against invading microorganisms and it is also activated in different neurologic/neurodegenerative pathological scenarios. As a result, the family of the innate immune toll-like receptors (TLRs) and, in particular, the genetic/pharmacological manipulation of the TLR-4 signalling pathway emerges as a potential ...
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