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Hall Jason C JC Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, - - 2014
Acute pancreatitis is associated with alcohol abuse, gallstones and bacterial infection. Its basic cause is tissue destruction accompanied by an innate immune response, which induces epithelial stress pathways. Recent studies have focused on some of the integral cellular pathways shared between multiple pancreatitis models that also suggest new approaches to ...
Sahin Umut U Université Paris Diderot, Sorbonne Paris Cité, Hôpital St. Louis, 1 Avenue Claude Vellefaux, 75475 PARIS cedex 10, France; INSERM UMR 944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d'Hématologie, Hôpital St. Louis, 1 Avenue Claude Vellefaux, 75475 PARIS cedex 10, France; CNRS UMR 7212, Hôpital St. Louis, 1 Avenue Claude Vellefaux, 75475 PARIS cedex 10, - - 2014
PML nuclear bodies (NBs) were first described by electron microscopy and re-discovered through their treatment-reversible disruption in a rare leukaemia. They recruit multiple partner proteins and now emerge as interferon- and oxidative stress-responsive sumoylation factories. NBs mediate interferon-induced viral restriction, enhance proteolysis, finely tune metabolism and enforce stress-induced senescence. Apart ...
Yang Qianqian Q Institute of Biotechnology, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China; Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, - - 2014
The high-osmolarity glycerol pathway plays an important role in the responses of fungi to various environmental stresses. Saccharomyces cerevisiae Skn7 is a response regulator in the high-osmolarity glycerol pathway, which regulates the oxidative stress response, cell cycle, and cell wall biosynthesis. In this study, we characterized a Skn7 orthologue BcSkn7 ...
Elgart M M Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, - - 2014
Organisms have to be sufficiently robust to function and reproduce despite environmental and genetic perturbations, yet plastic enough to cope with stressful scenarios to which they are not fully adapted. How this apparent conflict between robustness and plasticity is resolved at the cellular and whole organism levels is not clear. ...
Small David M DM The University of - - 2014
Mechanism(s) underlying renoprotection by peroxisome proliferator-activated receptor-gamma (PPARγ) agonists in diabetic and non-diabetic kidney disease are not well-understood. Mitochondrial dysfunction and oxidative stress contribute to kidney disease. PPARγ upregulates proteins required for mitochondrial biogenesis. Our aim was to determine whether PPARγ has a role in protecting kidney proximal tubular epithelium ...
Meares Gordon P GP Departments of Cell, Developmental and Integrative Biology - - 2014
Neuroinflammation and endoplasmic reticulum (ER) stress are associated with many neurological diseases. Here we have examined the interaction between ER stress and JAK/STAT-dependent inflammation in glial cells. We show that ER stress is present in the CNS concomitant with inflammation and astrogliosis in the Multiple Sclerosis (MS) mouse model of ...
Nardocci Gino G Facultad de Ciencias Biológicas y Facultad de Medicina, Universidad Andrés Bello, Santiago, Chile. Av. República 252, 8370134 Santiago, - - 2014
In the last years, the aquaculture crops have experienced an explosive and intensive growth, because of the high demand for protein. This growth has increased fish susceptibility to diseases and subsequent death. The constant biotic and abiotic changes experienced by fish species in culture are challenges that induce physiological, endocrine ...
Liong Stella - - 2014
Increasing evidence indicates that endoplasmic reticulum (ER) stress is involved in various diseases. In non-gestational tissues, several markers of the unfolded protein response (UPR) have been shown to regulate the inflammatory response. Thus, the aim of this study was to determine the effect of human labour on markers of ER ...
Feuerecker Matthias M 1 Department of Anaesthesiology, Klinikum Großhadern, University of Munich , Research Group Stress and Immunity, Munich, Germany - - 2014
Abstract Feuerecker, Matthias, Brian Crucian, Alex P. Salam, Ales Rybka, Ines Kaufmann, Marjan Moreels, Roel Quintens, Gustav Schelling, Manfred Thiel, Sarah Baatout, Clarence Sams, and Alexander Choukèr. Early adaption in the Antarctic environment at Dome C: Consequences on stress-sensitive innate immune functions. High Alt Med Biol 15:000-000, 2014.-Purpose/Aims: Medical reports ...
Strahler Jana J Department of Psychology, University of Marburg, Marburg, - - 2014
We have previously shown that psychosocial stress induces acute changes in glucocorticoid (GC) sensitivity of pro-inflammatory cytokine production. However, hormones of the sympathetic adrenal medullary system complement endocrine regulation of inflammatory responses. The current study therefore aimed at investigating the effects of repeated acute stress exposure on catecholamine sensitivity of ...
van Creveld Shiri Graff SG Department of Plant Sciences, Weizmann Institute of Science, Rehovot, - - 2014
Diatoms are ubiquitous marine photosynthetic eukaryotes that are responsible for about 20% of global photosynthesis. Nevertheless, little is known about the redox-based mechanisms that mediate diatom sensing and acclimation to environmental stress. Here we used a redox-sensitive green fluorescent protein sensor targeted to various subcellular organelles in the marine diatom ...
Carroll Jeffery A JA Livestock Issues Research Unit, USDA-ARS, Lubbock, TX 79403 - - 2014
Acknowledgment that modern livestock production systems impose stress upon animals has been accepted by the scientific community and producers. As the economic burden has increased for livestock producers, expectations for animal performance have increased, thus placing more strain upon the entire production system. Whether or not periodic exposure to stress ...
Wieck Andrea A Laboratory of Immunosenescence, Institute of Biomedical Research, Pontifical Catholic University of the Rio Grande do Sul (PUCRS), Porto Alegre, - - 2014
Mounting evidence suggests a chronic pro-inflammatory state in individuals with bipolar disorder (BD). Stress exposure is known to exacerbate several inflammatory conditions as well as psychiatric disorders. Here, we analyzed plasma levels of pro-inflammatory cytokines and their soluble receptors to realistic acute psychosocial stress challenge in BD. Thirteen euthymic type ...
Zhao Xilin X State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, South Xiang-An Road, Xiang-An District, Xiamen, Fujian Province 361102, China; Public Health Research Institute and Department of Microbiology & Molecular Genetics, New Jersey Medical School, Rutgers Biomedical and Health Sciences, 225 Warren Street, Newark, NJ 07103, USA. Electronic address: - - 2014
Bacteria are killed by a variety of lethal stressors, some of which promote a cascade of reactive oxygen species (ROS). Perturbations expected to alter ROS accumulation affect the lethal action of diverse antibacterials, leading to the hypothesis that killing by these agents can involve ROS-mediated self-destruction. Recent challenges to the ...
Alaux Cédric C INRA,France - - 2014
Host-parasite interactions are often characterized by changes in the host behaviour, which are either beneficial to the parasite or the host, or a non-adaptive byproduct of parasitism. Those interactions are further complicated in animal society since the individual fitness is associated with the group performance. However, a better understanding of ...
Messmer Michelle N MN Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, - - 2014
Physiologically accurate mouse models of cancer are critical in the pre-clinical development of novel cancer therapies. However, current standardized animal-housing temperatures elicit chronic cold-associated stress in mice, which is further increased in the presence of tumor. This cold-stress significantly impacts experimental outcomes. Data from our lab and others suggest standard ...
Smid Geert E GE Foundation Centrum '45/Arq, Diemen, The Netherlands. Electronic address: - - 2014
Combat stress exposed soldiers may respond to post-deployment stressful life events (SLE) with increases in symptoms of posttraumatic stress disorder (PTSD), consistent with a model of stress sensitization. Several lines of research point to sensitization as a model to describe the relations between exposure to traumatic events, subsequent SLE, and ...
Melnik Bodo C BC Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, - - 2014
Recent scientific interest in the pathogenesis of rosacea focuses on abnormally high facial skin levels of cathelicidin and the trypsin-like serine protease kallikrein 5 (KLK5) that cleaves the cathelicidin precursor protein into the bioactive fragment LL-37, which exerts crucial proinflammatory, angiogenic and antimicrobial activities. Furthermore, increased expression of Toll-like receptor-2 ...
Solanki Sumeet S University of - - 2014
Endoplasmic reticulum (ER) stress is a prominent mechanism of macrophage apoptosis in advanced atherosclerotic lesions. Recent studies from our laboratory showed that advanced atherosclerotic plaques in Apoe(-/-) mice with bone marrow deficiency of the calcium permeable channel Transient Receptor Potential Canonical 3 (TRPC3) are characterized by reduced areas of necrosis ...
Chauhan Anil Kumar AK Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 712-714,Republic of - - 2014
Salmonella is a common bacterial enteropathogen responsible for many deaths every year. In the present study, we evaluated the mechanism of action of thymol against Salmonella ser. Typhimurium, as well as its potential to induce intracellular killing and recovery from oxidative stress in macrophages. The minimum inhibitory concentration (MIC) of ...
Li Yiming Y Company Nine, Brigade of Undergraduates, The Fourth Military Medical University, Xi'an 710032, - - 2014
Endoplasmic reticulum stress (ER stress) is triggered due to a loss of homeostasis in the ER, resulting in accumulation of misfolded proteins in the ER lumen. ER stress activates a series of adaptive mechanisms known as the unfolded protein response. Perturbation of the ER is a powerful inducer of the ...
Dai Ming-Xiang MX Department of Cardiology, Xijing Hospital, The Fourth Military Medial University, Xi'an, Shaanxi, P.R. - - 2014
Background: The incidence of acute coronary syndrome caused by the rupture of atherosclerotic plaque and subsequent arterial thrombosis increases as the weather gets colder. However, the association between cold stress and atherosclerotic plaque rupture is currently unknown. Methods: An atherosclerotic plaque model was established in rabbits by balloon injury and ...
Ganguly Prabarna P Northeastern University, Psychology Department, 125 Nightingale Hall, 360 Huntington Avenue, Boston, MA 02115, USA. Electronic address: - - 2014
Exposure to adversity and stress early in development yields vulnerability to mental illnesses throughout the lifespan. Growing evidence suggests that this vulnerability has mechanistic origins involving aberrant development of both neurocircuitry and neuro-immune activity. Here we review the current understanding of when and how stress exposure initiates neuroinflammatory events that ...
Muscatell Keely A KA Robert Wood Johnson Foundation Health and Society Scholars Program, University of California, San Francisco and University of California, Berkeley, San Francisco, CA, USA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, - - 2015
Psychological stress is implicated in the etiology of many common chronic diseases and mental health disorders. Recent research suggests that inflammation may be a key biological mediator linking stress and health. Nevertheless, the neurocognitive pathways underlying stress-related increases in inflammatory activity are largely unknown. The present study thus examined associations ...
McLachlan Deirdre H DH The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, - - 2014
I. II. III. IV. V. References SUMMARY: Terrestrial plants rely on stomata, small pores in the leaf surface, for photosynthetic gas exchange and transpiration of water. The stomata, formed by a pair of guard cells, dynamically increase and decrease their volume to control the pore size in response to environmental ...
Kim Jung Mogg JM Department of Microbiology, Hanyang University College of Medicine, - - 2014
Dendritic cells (DCs) are observed on the Helicobacter pylori-infected gastric mucosa. DCs generally play an important role in the regulation of inflammation. Although stimulation of gastric epithelial cells with H. pylori vacuolating cytotoxin (VacA) has been reported to induce apoptosis and endoplasmic reticulum (ER) stress, the effects of VacA on ...
Lu Min M Cancer Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, - - 2014
Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption causes ER stress and augments disease. ER stress activates the unfolded protein response (UPR) to restore homeostasis. If stress persists, the UPR induces apoptotic cell death, but the mechanisms remain elusive. Here, we report that unmitigated ER stress ...
Lin Tzu-Kai TK 1] Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA, USA [2] Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan and Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, - - 2014
Acute psychological stress (PS) mobilizes metabolic responses that are of immediate benefit to the host, but the current medical paradigm holds that PS exacerbates systemic and cutaneous inflammatory disorders. Although the adverse consequences of PS are usually attributed to neuroimmune mechanisms, PS also stimulates an increase in endogenous glucocorticoids (GC) ...
Mahboubi Hicham H Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6, - - 2014
Nucleoli and cytoplasmic stress granules (SGs) are subcellular compartments that modulate the response to endogenous and environmental signals to control cell survival. In our opinion, nucleoli and SGs are functionally linked; they are distant relatives that combine forces when cellular homeostasis is threatened. Several lines of evidence support this idea; ...
Sleadd Isaac M IM Center for Life in Extreme Environments, Department of Biology, Portland State University, Portland, OR 97207, United - - 2014
The endemic fish fauna of the Southern Ocean are cold-adapted stenotherms and are acutely sensitive to elevated temperature. Many of these species lack a heat shock response and cannot increase the production of heat shock proteins in their tissues. However, some species retain the ability to induce other stress-responsive genes, ...
Kashyap Des Raj DR Indiana University School of Medicine-Northwest, Gary, Indiana, United States of - - 2014
Mammalian Peptidoglycan Recognition Proteins (PGRPs) are a family of evolutionary conserved bactericidal innate immunity proteins, but the mechanism through which they kill bacteria is unclear. We previously proposed that PGRPs are bactericidal due to induction of reactive oxygen species (ROS), a mechanism of killing that was also postulated, and later ...
Lee Eun Sang ES Division of Radiation Effects, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of - - 2014
Radiotherapy, which is one of the most effective approaches to the treatment of various cancers, plays an important role in malignant cell eradication in the pelvic area and abdomen. However, it also generates some degree of intestinal injury. Apoptosis in the intestinal epithelium is the primary pathological factor that initiates ...
Song Chi C Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing, 100081, - - 2014
High temperature is an important environmental factor that affects the growth and development of most edible fungi, however, the mechanism(s) for resistance to high temperature remains elusive. Nitric oxide is known to be able to effectively alleviate oxidative damage and plays an important role in the regulation of trehalose accumulation ...
Yung Hong Wa HW Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, - - 2014
Based on gestational age at diagnosis and/or delivery, pre-eclampsia (PE) is commonly divided into early-onset (<34 wk) and late-onset (≥34 wk) forms. Recently, the distinction between 'placental' and 'maternal' causation has been proposed, with 'placental' cases being more frequently associated with early-onset and intrauterine growth restriction. To test whether molecular ...
Zhao Chenyang C Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH - - 2014
The impact of environmental stressors on the magnitude of specific chemokine gene expression was examined in mouse bone marrow-derived macrophages stimulated through various TLRs. Levels of TLR-stimulated CXCL1 and CXCL2 but not CXCL10 or CCL5 mRNAs were selectively enhanced (>10-fold) in stressed macrophages. The amplification was also manifested for other ...
Yadav Sanjeev K SK Pineal Research Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, - - 2014
Throughout the year, birds encounter various environmental challenges such as extreme temperatures, rainfall and shortage of food. Here we report on the effect of stress on the general immunity of wild birds as measured by several assays including melatonin, an anti-stress hormone. We selected Perdicula asiatica, a wild tropical bird, ...
Ju X-H XH 1Department of Veterinary Medicine,Guangdong Ocean University,Zhanjiang - - 2014
Global warming is a challenge to animal health, because of increased heat stress, with subsequent induction of immunosuppression and increased susceptibility to disease. Toll-like receptors (TLR) are pattern recognition receptors that act as sentinels of pathogen invasion and tissue damage. Ligation of TLRs results in a signaling cascade and production ...
Barker Catriona E CE Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Newcastle University, NE2 4HH, - - 2014
Oxidative stress is a major and recurring cause of damage during inflammation, especially following organ transplantation. Initial ischaemia-reperfusion injury causes the production of many reactive oxygen and nitrogen species, and subsequent recruitment and activation of inflammatory cells can lead to further oxidative stress. This stress is well known to cause ...
Wu Haoxi - - 2014
Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in response to stress. One of the best-characterized pathways, the unfolded protein response (UPR), is an intracellular signal transduction pathway that monitors endoplasmic reticulum (ER) homeostasis. Its activation is required to alleviate the effects of ER stress and ...
Kuroiwa Masahiro M Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, - - 2014
After traumatic spinal cord injury (SCI), endoplasmic reticulum (ER) stress exacerbates secondary injury, leading to expansion of demyelination and reduced remyelination due to oligodendrocyte precursor cell (OPC) apoptosis. Although recent studies have revealed that amiloride controls ER stress and leads to improvement in several neurological disorders including SCI, its mechanism ...
Pyne David B DB Physiology, Australian Institute of Sport, Canberra, - - 2014
Heat and immune stress can affect athletes in a wide range of sports and environmental conditions. The classical thermoregulatory model of heat stress has been well characterised, as has a wide range of practical strategies largely centered on cooling and heat acclimation training. In the last decade evidence has emerged ...
Wang Xiaowu X Center of Cardiovascular Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, 510010, - - 2014
Exposure to humid heat stress leads to the initiation of serious physiological dysfunction that may result in heat-related diseases, including heat stroke, heat cramp, heat exhaustion, and even death. Increasing evidences have shown that the humid heat stress-induced dysfunction of the cardiovascular system was accompanied with severe cardiomyocyte injury; however, ...
Rao J J Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA; Department of Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu Province, - - 2014
Although the roles of the metabolic stress in organ ischemia-reperfusion injury (IRI) have been well recognized, the question of whether and how these stress responses regulate innate immune activation against IR remains unclear. In a murine liver partial warm ischemia mode, we showed that prolonged ischemia triggered endoplasmic reticulum (ER) ...
Chen Yaxi Y Centre for Lipid Research, Key Laboratory of Metabolism on Lipid and Glucose, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, - - 2014
Patients with chronic kidney disease (CKD) are unlikely to gain the same benefit from conventional doses of statins as do patients with cardiovascular disease alone. This study investigated whether inflammation accompanying CKD causes statin resistance. Inflammatory stress was induced by adding cytokines and lipopolysaccharide (LPS) to human mesangial cells (HMCs) ...
Lee Kyung-Tae KT Department of Biotechnology, Center for Fungal Pathogenesis, Yonsei University, Seoul 120-749, - - 2014
The iron uptake and utilization pathways play a critical role in allowing human pathogens, including Cryptococcus neoformans, the causative agent of fatal meningoencephalitis, to survive within the mammalian body by competing with the host for iron. Here we show that the iron regulon is also required for diverse environmental stress ...
Chang Yu-Ming YM Department of Internal Medicine, Division of Gastroenterology, University of Michigan, 3912 Taubman Center, SPC 5362, 1500 East Medical Center Drive, Ann Arbor, MI, - - 2014
Psychological stress is known to induce somatic symptoms. Classically, many gut physiological responses to stress are mediated by the hypothalamus-pituitary-adrenal axis. There is, however, a growing body of evidence of stress-induced corticotrophin-releasing factor (CRF) release causing bowel dysfunction through multiple pathways, either through the HPA axis, the autonomic nervous systems, ...
Zuo Li L The Ohio State University Wexner Medical Center - - 2014
Cigarette smoking (CS) can impact the immune system and induce pulmonary disorders such as chronic obstructive pulmonary disease (COPD), which is currently the fourth leading cause of chronic morbidity and mortality worldwide. Accordingly, the most significant risk factor associated with COPD is exposure to cigarette smoke. The purpose of the ...
Xu Min M Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, - - 2014
Neuregulin-1 (NRG-1) is a stress-mediated growth factor secreted by cardiovascular endothelial cells and provides the protection to myocardial cells, but the underlying mechanisms are not fully understood. This study aimed to demonstrate that NRG-1 protects myocardial cells exposed to oxidative damage by regulating endoplasmic reticulum (ER) stress. Neonatal rat cardiac ...
McClure Colin D CD Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK. - - 2014
Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost-free, artefacts of inbreeding, or come with deleterious side-effects. ...
Chen Si S Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR - - 2014
Sertraline is used for the treatment of depression, and is also used for the treatment of panic, obsessive-compulsive, and post-traumatic stress disorders. Previously, we have demonstrated that sertraline caused hepatic cytotoxicity, with mitochondrial dysfunction and apoptosis being underlying mechanisms. In this study, we used microarray and other biochemical and molecular ...
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