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Alaux Cédric C INRA,France - - 2014
Host-parasite interactions are often characterized by changes in the host behaviour, which are either beneficial to the parasite or the host, or a non-adaptive byproduct of parasitism. Those interactions are further complicated in animal society since the individual fitness is associated with the group performance. However, a better understanding of ...
Messmer Michelle N MN Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, - - 2014
Physiologically accurate mouse models of cancer are critical in the pre-clinical development of novel cancer therapies. However, current standardized animal-housing temperatures elicit chronic cold-associated stress in mice, which is further increased in the presence of tumor. This cold-stress significantly impacts experimental outcomes. Data from our lab and others suggest standard ...
Melnik Bodo C BC Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, - - 2014
Recent scientific interest in the pathogenesis of rosacea focuses on abnormally high facial skin levels of cathelicidin and the trypsin-like serine protease kallikrein 5 (KLK5) that cleaves the cathelicidin precursor protein into the bioactive fragment LL-37, which exerts crucial proinflammatory, angiogenic and antimicrobial activities. Furthermore, increased expression of Toll-like receptor-2 ...
Solanki Sumeet S University of - - 2014
Endoplasmic reticulum (ER) stress is a prominent mechanism of macrophage apoptosis in advanced atherosclerotic lesions. Recent studies from our laboratory showed that advanced atherosclerotic plaques in Apoe(-/-) mice with bone marrow deficiency of the calcium permeable channel Transient Receptor Potential Canonical 3 (TRPC3) are characterized by reduced areas of necrosis ...
Chauhan Anil Kumar AK Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 712-714,Republic of - - 2014
Salmonella is a common bacterial enteropathogen responsible for many deaths every year. In the present study, we evaluated the mechanism of action of thymol against Salmonella ser. Typhimurium, as well as its potential to induce intracellular killing and recovery from oxidative stress in macrophages. The minimum inhibitory concentration (MIC) of ...
Li Yiming Y Company Nine, Brigade of Undergraduates, The Fourth Military Medical University, Xi'an 710032, - - 2014
Endoplasmic reticulum stress (ER stress) is triggered due to a loss of homeostasis in the ER, resulting in accumulation of misfolded proteins in the ER lumen. ER stress activates a series of adaptive mechanisms known as the unfolded protein response. Perturbation of the ER is a powerful inducer of the ...
Dai Ming-Xiang MX Department of Cardiology, Xijing Hospital, The Fourth Military Medial University, Xi'an, Shaanxi, P.R. - - 2014
Background: The incidence of acute coronary syndrome caused by the rupture of atherosclerotic plaque and subsequent arterial thrombosis increases as the weather gets colder. However, the association between cold stress and atherosclerotic plaque rupture is currently unknown. Methods: An atherosclerotic plaque model was established in rabbits by balloon injury and ...
Muscatell Keely A KA Robert Wood Johnson Foundation Health and Society Scholars Program, University of California, San Francisco and University of California, Berkeley, San Francisco, CA, USA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, - - 2014
Psychological stress is implicated in the etiology of many common chronic diseases and mental health disorders. Recent research suggests that inflammation may be a key biological mediator linking stress and health. Nevertheless, the neurocognitive pathways underlying stress-related increases in inflammatory activity are largely unknown. The present study thus examined associations ...
McLachlan Deirdre H DH The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, - - 2014
I. II. III. IV. V. References SUMMARY: Terrestrial plants rely on stomata, small pores in the leaf surface, for photosynthetic gas exchange and transpiration of water. The stomata, formed by a pair of guard cells, dynamically increase and decrease their volume to control the pore size in response to environmental ...
Kim Jung Mogg JM Department of Microbiology, Hanyang University College of Medicine, - - 2014
Dendritic cells (DCs) are observed on the Helicobacter pylori-infected gastric mucosa. DCs generally play an important role in the regulation of inflammation. Although stimulation of gastric epithelial cells with H. pylori vacuolating cytotoxin (VacA) has been reported to induce apoptosis and endoplasmic reticulum (ER) stress, the effects of VacA on ...
Lu Min M Cancer Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, - - 2014
Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption causes ER stress and augments disease. ER stress activates the unfolded protein response (UPR) to restore homeostasis. If stress persists, the UPR induces apoptotic cell death, but the mechanisms remain elusive. Here, we report that unmitigated ER stress ...
Hall Jason C JC Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, - - 2014
Acute pancreatitis is associated with alcohol abuse, gallstones and bacterial infection. Its basic cause is tissue destruction accompanied by an innate immune response, which induces epithelial stress pathways. Recent studies have focused on some of the integral cellular pathways shared between multiple pancreatitis models that also suggest new approaches to ...
Lin Tzu-Kai TK 1] Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA, USA [2] Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan and Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, - - 2014
Acute psychological stress (PS) mobilizes metabolic responses that are of immediate benefit to the host, but the current medical paradigm holds that PS exacerbates systemic and cutaneous inflammatory disorders. Although the adverse consequences of PS are usually attributed to neuroimmune mechanisms, PS also stimulates an increase in endogenous glucocorticoids (GC) ...
Mahboubi Hicham H Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6, - - 2014
Nucleoli and cytoplasmic stress granules (SGs) are subcellular compartments that modulate the response to endogenous and environmental signals to control cell survival. In our opinion, nucleoli and SGs are functionally linked; they are distant relatives that combine forces when cellular homeostasis is threatened. Several lines of evidence support this idea; ...
Kashyap Des Raj DR Indiana University School of Medicine-Northwest, Gary, Indiana, United States of - - 2014
Mammalian Peptidoglycan Recognition Proteins (PGRPs) are a family of evolutionary conserved bactericidal innate immunity proteins, but the mechanism through which they kill bacteria is unclear. We previously proposed that PGRPs are bactericidal due to induction of reactive oxygen species (ROS), a mechanism of killing that was also postulated, and later ...
Lee Eun Sang ES Division of Radiation Effects, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of - - 2014
Radiotherapy, which is one of the most effective approaches to the treatment of various cancers, plays an important role in malignant cell eradication in the pelvic area and abdomen. However, it also generates some degree of intestinal injury. Apoptosis in the intestinal epithelium is the primary pathological factor that initiates ...
Song Chi C Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing, 100081, - - 2014
High temperature is an important environmental factor that affects the growth and development of most edible fungi, however, the mechanism(s) for resistance to high temperature remains elusive. Nitric oxide is known to be able to effectively alleviate oxidative damage and plays an important role in the regulation of trehalose accumulation ...
Yung Hong Wa HW Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, - - 2014
Based on gestational age at diagnosis and/or delivery, pre-eclampsia (PE) is commonly divided into early-onset (<34 wk) and late-onset (≥34 wk) forms. Recently, the distinction between 'placental' and 'maternal' causation has been proposed, with 'placental' cases being more frequently associated with early-onset and intrauterine growth restriction. To test whether molecular ...
Zhao Chenyang C Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH - - 2014
The impact of environmental stressors on the magnitude of specific chemokine gene expression was examined in mouse bone marrow-derived macrophages stimulated through various TLRs. Levels of TLR-stimulated CXCL1 and CXCL2 but not CXCL10 or CCL5 mRNAs were selectively enhanced (>10-fold) in stressed macrophages. The amplification was also manifested for other ...
Yadav Sanjeev K SK Pineal Research Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, - - 2014
Throughout the year, birds encounter various environmental challenges such as extreme temperatures, rainfall and shortage of food. Here we report on the effect of stress on the general immunity of wild birds as measured by several assays including melatonin, an anti-stress hormone. We selected Perdicula asiatica, a wild tropical bird, ...
Ju X-H XH 1Department of Veterinary Medicine,Guangdong Ocean University,Zhanjiang - - 2014
Global warming is a challenge to animal health, because of increased heat stress, with subsequent induction of immunosuppression and increased susceptibility to disease. Toll-like receptors (TLR) are pattern recognition receptors that act as sentinels of pathogen invasion and tissue damage. Ligation of TLRs results in a signaling cascade and production ...
Barker Catriona E CE Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Newcastle University, NE2 4HH, - - 2014
Oxidative stress is a major and recurring cause of damage during inflammation, especially following organ transplantation. Initial ischaemia-reperfusion injury causes the production of many reactive oxygen and nitrogen species, and subsequent recruitment and activation of inflammatory cells can lead to further oxidative stress. This stress is well known to cause ...
Wu Haoxi - - 2014
Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in response to stress. One of the best-characterized pathways, the unfolded protein response (UPR), is an intracellular signal transduction pathway that monitors endoplasmic reticulum (ER) homeostasis. Its activation is required to alleviate the effects of ER stress and ...
Kuroiwa Masahiro M Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, - - 2014
After traumatic spinal cord injury (SCI), endoplasmic reticulum (ER) stress exacerbates secondary injury, leading to expansion of demyelination and reduced remyelination due to oligodendrocyte precursor cell (OPC) apoptosis. Although recent studies have revealed that amiloride controls ER stress and leads to improvement in several neurological disorders including SCI, its mechanism ...
Pyne David B DB Physiology, Australian Institute of Sport, Canberra, - - 2014
Heat and immune stress can affect athletes in a wide range of sports and environmental conditions. The classical thermoregulatory model of heat stress has been well characterised, as has a wide range of practical strategies largely centered on cooling and heat acclimation training. In the last decade evidence has emerged ...
Wang Xiaowu X Center of Cardiovascular Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, 510010, - - 2014
Exposure to humid heat stress leads to the initiation of serious physiological dysfunction that may result in heat-related diseases, including heat stroke, heat cramp, heat exhaustion, and even death. Increasing evidences have shown that the humid heat stress-induced dysfunction of the cardiovascular system was accompanied with severe cardiomyocyte injury; however, ...
Rao J J Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA; Department of Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu Province, - - 2014
Although the roles of the metabolic stress in organ ischemia-reperfusion injury (IRI) have been well recognized, the question of whether and how these stress responses regulate innate immune activation against IR remains unclear. In a murine liver partial warm ischemia mode, we showed that prolonged ischemia triggered endoplasmic reticulum (ER) ...
Chen Yaxi Y Centre for Lipid Research, Key Laboratory of Metabolism on Lipid and Glucose, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, - - 2014
Patients with chronic kidney disease (CKD) are unlikely to gain the same benefit from conventional doses of statins as do patients with cardiovascular disease alone. This study investigated whether inflammation accompanying CKD causes statin resistance. Inflammatory stress was induced by adding cytokines and lipopolysaccharide (LPS) to human mesangial cells (HMCs) ...
Lee Kyung-Tae KT Department of Biotechnology, Center for Fungal Pathogenesis, Yonsei University, Seoul 120-749, - - 2014
The iron uptake and utilization pathways play a critical role in allowing human pathogens, including Cryptococcus neoformans, the causative agent of fatal meningoencephalitis, to survive within the mammalian body by competing with the host for iron. Here we show that the iron regulon is also required for diverse environmental stress ...
Chang Yu-Ming YM Department of Internal Medicine, Division of Gastroenterology, University of Michigan, 3912 Taubman Center, SPC 5362, 1500 East Medical Center Drive, Ann Arbor, MI, - - 2014
Psychological stress is known to induce somatic symptoms. Classically, many gut physiological responses to stress are mediated by the hypothalamus-pituitary-adrenal axis. There is, however, a growing body of evidence of stress-induced corticotrophin-releasing factor (CRF) release causing bowel dysfunction through multiple pathways, either through the HPA axis, the autonomic nervous systems, ...
Zuo Li L The Ohio State University Wexner Medical Center - - 2014
Cigarette smoking (CS) can impact the immune system and induce pulmonary disorders such as chronic obstructive pulmonary disease (COPD), which is currently the fourth leading cause of chronic morbidity and mortality worldwide. Accordingly, the most significant risk factor associated with COPD is exposure to cigarette smoke. The purpose of the ...
Xu Min M Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, - - 2014
Neuregulin-1 (NRG-1) is a stress-mediated growth factor secreted by cardiovascular endothelial cells and provides the protection to myocardial cells, but the underlying mechanisms are not fully understood. This study aimed to demonstrate that NRG-1 protects myocardial cells exposed to oxidative damage by regulating endoplasmic reticulum (ER) stress. Neonatal rat cardiac ...
McClure Colin D CD Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK. - - 2014
Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost-free, artefacts of inbreeding, or come with deleterious side-effects. ...
Chen Si S Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR - - 2014
Sertraline is used for the treatment of depression, and is also used for the treatment of panic, obsessive-compulsive, and post-traumatic stress disorders. Previously, we have demonstrated that sertraline caused hepatic cytotoxicity, with mitochondrial dysfunction and apoptosis being underlying mechanisms. In this study, we used microarray and other biochemical and molecular ...
Giovanoli Sandra S Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, - - 2014
Exposure to prenatal infection and traumatizing experiences in peripubertal life are two environmental risk factors for developmental neuropsychiatric disorders. Modelling the cumulative neuronal impact of these factors in a translational animal model has led to the recent identification of pathological interactions between these environmental adversities in the development of adult ...
Binker Marcelo G MG Marcelo G Binker, Laura I Cosen-Binker, CBRHC Research Center, 1053 Ciudad Autónoma de Buenos Aires, Buenos Aires 1426, - - 2014
Acute pancreatitis is an inflammatory disorder of the pancreas that may cause life-threatening complications. Etiologies of pancreatitis vary, with gallstones accounting for the majority of all cases, followed by alcohol. Other causes of pancreatitis include trauma, ischemia, mechanical obstruction, infections, autoimmune, hereditary, and drugs. The main events occurring in the ...
Guo Monica S MS Department of Microbiology and Immunology, University of California, San Francisco, CA 94158, USA; Department of Cell and Tissue Biology, University of California, San Francisco, CA 94158, - - 2014
Microorganisms live in fluctuating environments, requiring stress response pathways to resist environmental insults and stress. These pathways dynamically monitor cellular status, and mediate adaptive changes by remodeling the proteome, largely accomplished by remodeling transcriptional networks and protein degradation. The complementarity of fast, specific proteolytic degradation and slower, broad transcriptomic changes ...
Huang Hongbiao H Protein Modification and Degradation Lab, Department of Pathophysiology, Guangzhou Medical College, Guangdong 510182, People's Republic of - - 2014
Anacardic acid (6-pentadecylsalicylic acid, AA), a natural compound isolated from the traditional medicine Amphipterygium adstringens, has been reported to possess antitumor activities. However, its molecular targets have not been thoroughly studied. Here, we report that AA is a potent inducer of endoplasmic reticulum (ER) stress, leading to apoptosis in hepatoma ...
McCormick Gail L GL Intercollege Graduate Degree Program in Ecology, Department of Biology, and The Center for Brain, Behavior and Cognition, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA. Electronic address: - - 2014
Prolonged elevations of glucocorticoids due to long-duration (chronic) stress can suppress immune function. It is unclear, however, how natural stressors that result in repeated short-duration (acute) stress, such as frequent agonistic social encounters or predator attacks, fit into our current understanding of the immune consequences of stress. Since these types ...
Yan Yutao Y Department of Immunology, Tongji Medical College, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 4340030, - - 2014
Extracellular hypotonic stress can affect cellular function. Whether and how hypotonicity affects immune cell function remains to be elucidated. Macrophages are immune cells that play key roles in adaptive and innate in immune reactions. The purpose of this study was to investigate the role and underlying mechanism of hypotonic stress ...
Shih Jing-Wen JW Integrated Laboratory, Center of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, - - 2014
Environmental stresses threatening cell homeostasis trigger various cellular responses ranging from the activation of survival pathways to eliciting programmed cell death. Cellular stress response highly depends on the nature and level of the insult as well as the cell type. Notably, the interplay among all these responses will ultimately determine ...
Bisti Silvia S University of L'Aquila, DISCAB, L'Aquila, - - 2014
Age-related macular degeneration (AMD) is a retinal neurodegenerative disease whose development and progression are the results of a complex interaction between genetic and environmental risk factors. Both oxidative stress and chronic inflammation play a significant role in the pathogenesis of AMD. Experimental studies in rats with light-induced photoreceptors degeneration demonstrated ...
Dey Sumanta S Department of Infectious Diseases and Immunology, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West Bengal, - - 2014
Liver efficiently restores function after damage induced during malarial infection once the parasites get cleared from the blood. However, the molecular events leading to the restoration of liver function after malaria are still obscure. To study this, we developed a suitable model wherein mice infected with Plasmodium yoelii (45% parasitemia) ...
Dhabhar Firdaus S FS Department of Psychiatry and Behavioral Sciences, Institute for Immunity, Transplantation, and Infection, Neurosciences Institute, Cancer Institute, Stanford University, 300 Pasteur Drive, MC 5135, Stanford, CA, 94305-5135, USA, - - 2014
Although the concept of stress has earned a bad reputation, it is important to recognize that the adaptive purpose of a physiological stress response is to promote survival during fight or flight. While long-term stress is generally harmful, short-term stress can be protective as it prepares the organism to deal with challenges. ...
Bronson Stefanie L SL Dept. of Animal Biology, University of Pennsylvania School of Veterinary - - 2014
Adverse experiences during gestation such as maternal stress and infection are known risk factors for neurodevelopmental disorders, including schizophrenia, autism, and attention deficit/hyperactivity disorder. The mechanism by which distinct exposures may confer similar psychiatric vulnerability remain unclear, although likely involve pathways common to both stress and immune responses at the ...
Selvakumar Govindasamy Pushpavathi GP Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, 608 002, Tamil Nadu, - - 2014
Parkinson's disease (PD) is a common, chronic, and debilitating neurodegenerative disorder characterized by progressive loss of nigrostriatal dopaminergic neurons due to unknown factors. In the present study, we have evaluated if escin, a triterpene saponin from seeds of horse chestnut tree (Aesculus hippocastanum), offers neuroprotection against chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/p)-induced toxicity ...
Hill Geoffrey E GE Department of Biological Sciences, 331 Funchess Hall, Auburn University, Auburn, AL 36849-5414, - - 2014
A fundamental hypothesis for the evolution and maintenance of ornamental traits is that ornaments convey information to choosing females about the quality of prospective mates. A diverse array of ornaments (e.g., colors, morphological features, and behaviors) has been associated with a wide range of measures of individual quality, but decades ...
Kose Shingo S Cellular Dynamics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. Electronic address: - - 2014
In eukaryotic cells, molecular trafficking between the nucleus and cytoplasm is a highly regulated process related to cellular homeostasis and cellular signaling. However, various cellular stresses induce the perturbation of conventional nucleocytoplasmic transport pathways, resulting in the nucleocytoplasmic redistribution of many functional proteins. We describe the recent insights into the ...
Yang Kyung Mi KM Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul 120-749, - - 2014
ω-Hydroxyundec-9-enoic acid (ω-HUA), a hydroxyl unsaturated fatty acid derivative, is involved in the antifungal activity of wild rice (Oryza officinalis). Here, we investigated the anti-cancer activity of ω-HUA on a non-small cell lung cancer (NSCLC) cell line. ω-HUA increased apoptosis and induced cleavages of caspase-6, caspase-9, and poly (ADP-ribose) polymerase ...
Zhiqing Zhang Z Institute of Health & Environmental Medicine, Tianjin, 300050, People's Republic of - - 2014
Moderate levels of stress can be beneficial to health, while stress overload can cause injury or contribute to diseases. Despite a number of studies of adaptation or stress damage, the mechanisms of adaptation and stress damage remain far from clear. The effect and mechanisms of adaptation on cardiomyocytes damage caused ...
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