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Warner Neil N University of Michigan, United - - 2014
NOD2 encodes an intracellular multi-domain pattern recognition receptor that is the strongest known genetic risk factor in the pathogenesis of Crohns disease (CD), a chronic relapsing inflammatory disorder of the intestinal tract. NOD2 functions as a sensor for bacterial cell wall components and activates pro-inflammatory and anti-microbial signaling pathways. Here, ...
Chen L L Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, - - 2014
Interleukin-23 (IL-23) responsive group 3 innate lymphoid cells (ILC3s) have been implicated in immune homeostasis and pathogenesis in the adult, but little is known about their roles in the newborn. Here we show that IL-23 promotes conversion of embryonic intestinal Lin(-)IL-23R(+)Thy1(+) cells into IL-22-producing Thy1(+)Sca-1(hi) ILC3s in vitro. Gut-specific expression ...
Bain Calum C CC 1] Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow, Scotland, UK. [2] - - 2014
The paradigm that macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which contains the largest pool of macrophages. Using fate-mapping models and monocytopenic mice, together with bone marrow chimera and parabiotic models, we found that embryonic precursor cells seeded the ...
Zhu Caixia C State Key Laboratory of Forest Genetics and Tree Breeding, Northeast Forestry University, Harbin, 150040, China; College of Life Sciences, Northeast Forestry University, Harbin, 150040, - - 2014
The aim of this study was to observe the effect of the Rhodiola crenulata extracts on gut immunity of Drosophila melanogaster. Wild-type flies fed standard cornmeal-yeast medium were used as controls. Experimental groups were supplemented with 2.5% R. crenulata aqueous extracts in standard medium. Survival rate was determined by feeding pathogenic ...
Nguyen Duc Ninh DN University of - - 2014
A balance between pro- and anti-inflammatory signals from the milk and microbiota controls intestinal homeostasis just after birth, and an optimal balance is particularly important for preterm neonates that are sensitive to necrotizing enterocolis (NEC). We suggest that the intestinal cytokine IL-8 plays an important role and hypothesize that transforming ...
Mukherjee Subhadeep S Division of Immunology, National Institute of Cholera and Enteric Diseases, P-33, CIT Road, Scheme-XM, Kolkata-700 010, West Bengal, - - 2014
Interferon (IFN)-γ and tumor necrosis factor (TNF)-α cause chronic inflammation of the intestine leading to progression of inflammatory bowel disease (IBD), which is manifested through rapid apoptosis of the intestinal epithelial cells (iECs). Here, we show inhibition of IFN-γ and TNF-α-induced apoptosis of INT-407 cells by porin, a microbe-associated molecular ...
Johnson-Henry Kathene C KC Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, - - 2014
Few studies have focused on the ability of prebiotics to prevent pathogen-induced cellular changes or alter the composition of the intestinal microbiota in complimentary relevant cell and animal models of inflammatory bowel disease. The objective of this study was to determine if pretreatment with inulin and a short-chain fructo-oligosaccharide (sc-FOS) ...
Hyun Jinhee J Division of Gastroenterology, Department of Medicine, Miami, Fla., - - 2014
In the intestine, interaction between epithelial cells and macrophages (MΦs) create a unique immunoregulatory microenvironment necessary to maintain local immune and tissue homeostasis. Human intestinal epithelial cells (IECs) have been shown to express interleukin (IL)-10, which keeps epithelial integrity. We have demonstrated that bacterial signaling through Toll-like receptor (TLR) 4 ...
Gabutti Giovanni G Department of Medical Sciences; University of Ferrara; Ferrara, - - 2014
Pertussis continues to be an important public-health issue. The high immunization coverage rates achieved, mainly in industrialized countries, have certainly decreased the spread of the pathogen. However, as immunity wanes, adolescents and adults play an important role in the dynamics of the infection. The surveillance system has several limitations and ...
Ramanan Deepshika D Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Sackler Institute of Graduate Biomedical Science, New York University School of Medicine, New York, NY 10016, - - 2014
Nod2 has been extensively characterized as a bacterial sensor that induces an antimicrobial and inflammatory gene expression program. Therefore, it is unclear why Nod2 mutations that disrupt bacterial recognition are paradoxically among the highest risk factors for Crohn's disease, which involves an exaggerated immune response directed at intestinal bacteria. Here, ...
Engler Daniela B DB Institute of Molecular Cancer Research, University of Zürich, 8057 Zürich, - - 2014
The prevalence of allergic asthma and other atopic diseases has reached epidemic proportions in large parts of the developed world. The gradual loss of the human indigenous microbiota has been held responsible for this trend. The bacterial pathogen Helicobacter pylori is a constituent of the normal gastric microbiota whose presence ...
Valentin-Weigand Peter P Institute for Microbiology, University of Veterinary Medicine Hannover, 30173 Hannover, - - 2014
Enteropathogenic Yersinia enterocolitica bioserotype 4/O:3 are the most frequent cause of human yersiniosis worldwide with symptoms ranging from mild diarrhea to severe complications of mesenteric lymphadenitis, liver abscesses and postinfectious extraintestinal sequelae. The main reservoir host of 4/O:3 strains are pigs, which represent a substantial disease-causing potential for humans, as ...
Engel Elodie - - 2014
BackgroundRapid activation of innate immune defences upon microbial infection depends on the evolutionary conserved NF-¿B dependent signals which deregulation is frequently associated with chronic inflammation and oncogenesis. These signals are tightly regulated by the linkage of different kinds of ubiquitin moieties on proteins that modify either their activity or their ...
Liang Qian Q Department of Pain Management, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, - - 2014
This study aims to investigate the mechanism by which resveratrol (RV) prevents sodium nitroprusside (SNP)-induced chondrocyte apoptosis, which is a characteristic feature of osteoarthritis (OA). Rabbit articular chondrocytes were pre-incubated with 100 μM RV for 18 h before 1.5 mM SNP co-treatment for 6 h. Cell viability was evaluated by CCK-8. Annexin V/PI double staining ...
Chang C C CC Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, 3000, - - 2014
An immune reconstitution disorder occurs in up to 40 % of severely immunodeficient HIV patients who commence antiretroviral therapy (ART), with an immune reconstitution inflammatory syndrome (IRIS) being encountered most commonly. Differences in the immunopathogenesis of an IRIS associated with different types of pathogen have become apparent but common features have ...
- - 2014
ATP11C and CDC50A flippase activity prevents phosphatidylserine externalization and phagocytosis.
Xu Shujun S Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, Zhejiang, - - 2014
Rosiglitazone has been known to attenuate neurodegeneration in Alzheimer's disease (AD), but the underlying mechanisms remain unclear. In this study, Morris water maze test, ELISA and electrophysiological methods were used to examine the role and underling mechanisms of rosiglitazone on Aβ42 oligomer-induced memory impairments. We found that rosiglitazone attenuated Aβ42 ...
Geuking Markus B MB Mucosal Immunology Lab; Department of Clinical Research; University of Bern; Bern, - - 2014
The impact of the gut microbiota on immune homeostasis within the gut and, importantly, also at systemic sites has gained tremendous research interest over the last few years. The intestinal microbiota is an integral component of a fascinating ecosystem that interacts with and benefits its host on several complex levels ...
Holtan Shernan G SG Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, United - - 2014
Over the past five years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have already reached ...
Harkcom William T WT Department of - - 2014
Nicotinamide adenine dinucleotide (NAD(+)) is an endogenous enzyme cofactor and cosubstrate that has effects on diverse cellular and physiologic processes, including reactive oxygen species generation, mitochondrial function, apoptosis, and axonal degeneration. A major goal is to identify the NAD(+)-regulated cellular pathways that may mediate these effects. Here we show that ...
Sykes Lynne L L Sykes, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Imperial College london, United Kingdom - - 2014
Preterm birth occurs in 10-12% of pregnancies and is the primary cause of neonatal mortality and morbidity. Tocolytic therapies have long been the focus for the prevention of preterm labour yet they do not significantly improve neonatal outcome. A direct causal link exists between infection-induced inflammation and preterm labour. Tocolytics ...
Choi Won-Seok WS School of Biological Sciences and Technology, College of Natural Sciences, College of Medicine, Chonnam National University, Gwangju 500-757, Korea. ; Department of Biology, Yonsei University College of Life Science and Biotechnology, Seoul 120-749, - - 2014
Calbindin-D28K has been implicated in the regulation of neuronal cell death. Previously, we demonstrated that calbindin-D28K prevents staurosporine (STS)-induced caspase activation and subsequent apoptosis in a neuronal cell line. However, the role of calbindin-D28K in STS-induced activation of calpain and necrotic cell death was not identified. Staurosporine induced the elevation ...
Campbell Stephanie S Li Ka Shing Institute for Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2S2, - - 2014
Apoptosis is a tightly regulated process that plays a crucial role in the removal of virally infected cells; a process controlled by both pro- and anti-apoptotic members of the Bcl-2 family. The pro-apoptotic proteins Bak and Bax are regulated by anti-apoptotic Bcl-2 proteins and are also activated by a subset ...
Fray Michael A MA Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, - - 2014
The inappropriate expansion of self-reactive "bystander" T cells can contribute to autoimmune disease. In this issue of Immunity, Watanabe et al. (2014) demonstrate that the tumor suppressor p53 prevents the cytokine-dependent proliferation of T cells in the absence of cognate antigens.
Mantovani Alberto A Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy. Electronic address: - - 2014
Macrophages in the gut originate from blood precursors and have distinct functional properties. In this issue of Immunity,Zigmond et al. (2014) and Shouval et al. (2014) report that interleukin-10 drives macrophages to express homeostatic tolerogenic functions, preventing colitis.
Cutone Antimo A Department of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, - - 2014
Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up- or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system. Ferroportin is a key player in maintenance of correct iron homeostasis, because it is ...
Galbiati Valentina V Laboratory of Toxicology, DiSFeB, Università degli Studi di Milano, Milan, - - 2014
Keratinocytes play a key role in all phases of allergic contact dermatitis. We have recently identified the possibility to use IL-18 production for the in vitro identification of contact allergens. The purpose of this study was to characterize the molecular mechanisms underlying allergen-induced IL-18 production, in order to identify the ...
Zahn S S Department of Dermatology, University of Bonn, - - 2014
Irradiation with ultraviolet (UV) light is an important exacerbating factor in cutaneous lupus erythematosus (CLE) and induces various effects in the skin of patients with the disease, such as cell death and inflammation. Recently, we demonstrated the ability of a broad-spectrum sunscreen to prevent UV-induced damage both in patients with ...
Abt Michael C MC Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center New York, New York, USA. Electronic address: - - 2014
Commensal bacterial communities residing within the intestinal lumen of mammals have evolved to flourish in this microenvironment. To preserve this niche, commensal bacteria act with the host to prevent colonization by invasive pathogens that induce inflammation and disrupt the intestinal niche commensal bacteria occupy. Thus, it is mutually beneficial to ...
Nussenblatt Robert B RB The National Eye Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: - - 2014
To describe the immune alterations associated with, age related macular degeneration (AMD). Based on these findings, to offer an approach to possibly prevent the expression of late disease. Perspective METHODS: Review of the existing literature dealing with epidemiology, models, and immunologic findings in patients. Significant genetic associations have been identified ...
Nair Nandini N Division of Cardiology, Scott & White Hospital, Texas A&M HSC College of Medicine, Temple, Texas; Sacred Heart Medical Center/Providence Spokane Heart Institute, Spokane, Washington. Electronic address: - - 2014
Cancers in post-transplant patients exhibit the same molecular and cellular properties as those in their non-transplanted counterparts and arise secondary to uncontrolled/sustained growth, apoptosis resistance, inhibition of tumor suppressors, immortalization of cells with invasion, and and metastasis. Disruption of DNA repair mechanisms, upregulation of angiogenic growth factors, impaired viral immunity ...
Figarola James L JL Departments of Diabetes and Metabolic Diseases Research, Beckman Research Institute of the City of Hope National Medical Center, NCI Designated Comprehensive Cancer Center, Gonda North, RM # 2108, 1500 E. Duarte Rd, Duarte, CA, 91010, - - 2014
Methylglyoxal (MGO) is a highly reactive dicarbonyl compound known to induce cellular injury and cytoxicity, including apoptosis in vascular cells. Vascular endothelial cell apoptosis has been implicated in the pathophysiology and progression of atherosclerosis. We investigated whether the advanced glycation end-product inhibitor LR-90 could prevent MGO-induced apoptosis in human umbilical ...
Na Ha-Na HN Department of Biotechnology, The Catholic University of Korea, Bucheon, 420-743, - - 2014
Adenovirus 36 (Ad36) is known to be associated with human obesity and to trigger inflammation in murine models. However, no clinical drugs have to date been developed to treat virus-induced obesity. Therefore, in this study, we evaluated the anti-obesity and anti-inflammation effects of mulberry extract on Ad36. The mulberry extract-fed ...
Flores-García Aurelio - - 2014
Sporotrichosis is a cutaneous fungal infection caused by Sporothrix schenckii. It is known to be mainly contained by Th1 responses. As IL-12 is crucial for Th1 response, we investigated if treatment with recombinant murine IL-12 (rmIL-12) promoted Th1 immunity and/or clinical improvement in an experimental sporotrichosis gerbil model. Gerbils were ...
Kim Seok-Jo SJ Northwestern University Feinberg School of Medicine, United - - 2014
Mitochondria-targeted human 8-oxoguanine DNA glycosylase (mt-hOgg1) and aconitase-2 (Aco-2) each reduce oxidant-induced alveolar epithelial cell (AEC) apoptosis but it is unclear whether protection occurs by preventing AEC mitochondrial DNA (mtDNA) damage. Using quantitative PCR-based measurements of mitochondrial and nuclear DNA damage, mtDNA damage was preferentially noted in AEC following exposure ...
Emr Bryanna B ¶ Department of Surgery, SUNY Upstate University, Syracuse NY 13210 * Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213 § Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219 ¥ Department of Computational and Systems Biology, University of Pittsburgh, PA 15260 # Department of Biologic Sciences, SUNY Cortland, Cortland, NY 13045 $ Department of Surgery, University of Chicago, Chicago, IL - - 2014
Sepsis-induced inflammation in the gut/peritoneal compartment occurs early in sepsis, and can lead to acute lung injury (ALI). We have suggested that inflammatory ascites drives the pathogenesis of ALI, and that removal of ascites with an abdominal wound vacuum prevents ALI. We hypothesized that the time- and compartment-dependent changes in ...
Kobayashi Teruyoshi T Graduate School of Economics, Kobe University, 2-1 Rokkodai, Nada, Kobe 657-8501, - - 2014
Many immunization strategies have been proposed to prevent infectious viruses from spreading through a network. In this work, we study efficient immunization strategies to prevent a default contagion that might occur in a financial network. An essential difference from the previous studies on immunization strategy is that we take into ...
Fridmann-Sirkis Yael Y Department of Biological Chemistry, Weizmann Institute of Science Rehovot, - - 2014
Commensal gut bacteria in many species including flies are integral part of their host, and are known to influence its development and homeostasis within generation. Here we report an unexpected impact of host-microbe interactions, which mediates multi-generational, non-Mendelian inheritance of a stress-induced phenotype. We have previously shown that exposure of ...
Yang Tsai-Hsiu TH Department of Health and Nutrition, Chia-Nan University of Pharmacy and Science, Tainan 71710, Taiwan. - - 2014
UVA contributes to the pathogenesis of skin aging by downregulation of procollagen I content and induction of matrix metalloproteinase (MMP)-associated responses. Application of antioxidants such as lycopene has been demonstrated as a convenient way to achieve protection against skin aging. Lycogen™, derived from the extracts of Rhodobacter sphaeroides, exerts several ...
Khurana Sandhya S 0000-0002-3263-9840 Medical Sciences Division, Northern Ontario School of Medicine, Laurentian University, Sudbury, ON, Canada P3E - - 2014
Reactive oxygen species trigger cardiomyocyte cell death via increased oxidative stress and have been implicated in the pathogenesis of cardiovascular diseases. The prevention of cardiomyocyte apoptosis is a putative therapeutic target in cardioprotection. Polyphenol intake has been associated with reduced incidences of cardiovascular disease and better overall health. Polyphenols like ...
Cauwels A A 1] Inflammation Research Center, VIB, Ghent, Belgium [2] Department of Biomedical Molecular Biology, Ghent University, Ghent, - - 2014
Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of several toxic and damaging molecules. These are necessary to fight and resolve the cause of SIRS, ...
Lu Chen C 1. Institute of Materia, Fourth Military Medical University, Xi'an 710032, - - 2014
Parkinson's disease (PD) is the second most prevalent progressive neurodegenerative disease. Although several hypotheses have been proposed to explain the pathogenesis of PD, apoptotic cell death and oxidative stress are the most prevalent mechanisms. Tetramethylpyrazine (TMP) is a biological component that has been extracted from Ligusticum wallichii Franchat (ChuanXiong), which ...
Pallas Merce M Unitat de Farmacologia i Farmacognosia Facultat de Farmacia, Avda Diagonal 643. 08028- Barcelona, - - 2014
Resveratrol has been extensively investigated and has been demonstrated to have antioxidant properties, cancer chemopreventive activity, and the capacity to modulate the hepatic synthesis of triglycerides and cholesterol, among others well established actions. A noteworthy feature of resveratrol is its ability to cross the blood-brain barrier and to exhibit neuroprotective ...
Buttari Brigitta B 0000-0002-0575-4106 Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, - - 2014
the proinflammatory M1 subset and the anti-inflammatory M2 one. 7-oxo-cholesterol, the most abundant cholesterol autoxidation product within atherosclerotic plaque, is able to skew the M1/M2 balance towards a proinflammatory profile. In the present study, we explored the ability of the polyphenolic compound resveratrol to counteract the 7-oxo-cholesterol-triggered proinflammatory signaling in ...
Alonso Carmen C Neuro-Immuno-Gastroenterology Group, Digestive Diseases Research Unit, Gastroenterology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Paseo Vall d'Hebron 119-129, 08035, Barcelona, - - 2014
The luminal-mucosal interface of the intestinal tract is the first relevant location where microorganism-derived antigens and all other potentially immunogenic particles face the scrutiny of the powerful mammalian immune system. Upon regular functioning conditions, the intestinal barrier is able to effectively prevent most environmental and external antigens to interact openly ...
Su Xiaomin X 1] Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China - - 2014
The innate immune-dependent bactericidal effects are critical for preventing microbial colonization in the urinary system. However, the mechanisms involved in establishing innate immune responses in kidney are not completely understood. Here we describe the role of a novel member of the LRR (leucine-rich repeat) class of transmembrane proteins, LRRC19 (LRR-containing ...
Guo Jintao J Department of Pathology and Bosch Institute, The University of Sydney, Sydney, NSW 2006, - - 2014
Cerebral malaria (CM) is a severe complication of and a leading cause of death due to Plasmodium falciparum infection. CM is likely the result of interrelated events, including mechanical obstruction due to parasite sequestration in the microvasculature, and upregulation of Th1 immune responses. In parallel, blood-brain-barrier (BBB) breakdown and damage ...
Latorre Eva E Department of Pharmacology and Physiology, Faculty of Veterinary Sciences, University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, - - 2014
Oxidative stress is thought to play a key role in the development of intestinal damage in intestinal inflammatory diseases. Several molecules are involved in the intestinal inflammation, either as pro- or anti-inflammatory factors; however, their effects on intestinal oxidative stress seem to be controversial. This work analyzes the contribution of ...
Sakai Fumihiko F Milk Science Research Institute, Megmilk Snow Brand Co. Ltd., Minamidai, Kawagoe, Saitama, - - 2014
Probiotic bacteria provide benefits in enhancing host immune responses and protecting against infection. Induction of IgA production by oral administration of probiotic bacteria in the intestine has been considered to be one reason for this beneficial effect, but the mechanisms of the effect are poorly understood. Lactobacillus gasseri SBT2055 (LG2055) ...
Ueshima Shigeyuki S Department of Surgery, Osaka University Graduate School of - - 2014
Gastrointestinal dysmotility is frequently observed under septic conditions, yet its precise mechanisms remain to be elucidated. In this study, we have investigated the mechanisms of intestinal dysmotility by lipopolysaccharides (LPS) and the role of the interstitial cells of Cajal (ICCs) in motility disorders using a mouse endotoxin model. The injection ...
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