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Nijland Philip G - - 2014
Recent evidence suggests that reactive oxygen species (ROS) produced by inflammatory cells drive axonal degeneration in active multiple sclerosis (MS) lesions by inducing mitochondrial dysfunction. Mitochondria are endowed with a variety of antioxidant enzymes, including peroxiredoxin-3 and thioredoxin-2, which are involved in limiting ROS-induced damage. In this study, we explored ...
Huang Siqin S Traditional Chinese Medicine College, Chongqing Medical University, No.1 Medical College Road, Yuzhong District, Chongqing, 400016, - - 2014
Electroacupuncture (EA) has been used worldwide to treat demyelinating diseases, but its therapeutic mechanism is poorly understood. In this study, a custom-designed model of compressed spinal cord injury (CSCI) was used to induce demyelination. Zusanli (ST36) and Taixi (KI3) acupoints of adult rats were stimulated by EA to demonstrate its ...
Chiurchiu Valerio V European Center for Brain Research (CERC), I.R.C.C.S. Santa Lucia Foundation, via del Fosso di Fiorano 64, 00143, Rome, Italy.. - - 2014
Despite multiple sclerosis (MS) represents one of the most fascinating mystery of modern medicine due to its unknown etiology and the incomplete knowledgeof a clear mechanism of pathogenesis, progress against this disease has made giant leaps. Current management of MS takes advantage of many disease-modifying therapeutics of anti-inflammatory and immunomodulatory ...
Peferoen Laura A N LA From the Departments of Pathology (LANP, DYSV, KU, WHG, RMBP-B, PvdV, SA) and Molecular Cell Biology and Immunology (DYSV, MB, PDAMH, CDD), VU University Medical Center, Amsterdam, The Netherlands; and Neuroimmunology Unit, Blizard Institute, Barts and the London School of Medicine Dentistry, Queen Mary University of London, London, United Kingdom - - 2014
Similar to macrophages, microglia adopt diverse activation states and contribute to repair and tissue damage in multiple sclerosis. Using reverse transcription-quantitative polymerase chain reaction and immunohistochemistry, we show that in vitro M1-polarized (proinflammatory) human adult microglia express the distinctive markers CD74, CD40, CD86, and CCR7, whereas M2 (anti-inflammatory) microglia express ...
Moore Spencer M SM http://orcid.org/0000-0001-9811-9007 Department of - - 2014
Currently available immunomodulatory therapies do not stop the pathogenesis underlying multiple sclerosis (MS) and are only partially effective in preventing the onset of permanent disability in patients with MS. Identifying a drug that stimulates endogenous remyelination and/or minimizes axonal degeneration would reduce the rate and degree of disease progression. Here, ...
Wang Xi X W. M. Keck Center for Collaborative Neuroscience, Rutgers, The State University of New Jersey, New Jersey; Institute of Neurosciences, the Fourth Military Medical University, Xian, - - 2014
Macrophage activation and persistent inflammation contribute to the pathological process of spinal cord injury (SCI). It was reported that M2 macrophages were induced at 3-7 days after SCI but M2 markers were reduced or eliminated after 1 week. By contrast, M1 macrophage response is rapidly induced and then maintained at ...
Bouzabata Amel A Université de Corse-CNRS, UMR 6134 SPE, Equipe Chimie et Biomasse, Route des Sanguinaires, 20000 Ajaccio, - - 2014
In Algeria, Myrtus communis L. is distributed throughout the Tell Atlas and the coastal regions of Algiers and Constantine. The leaves are used in respiratory disorders, diarrhea and hemorrhoids. The aims of this work were to evaluate the antifungal and anti-inflammatory potential of well characterized essential oils (EO). Since EO ...
Schmitz Katja K The MS study group of the TRIP-Graduate School, Goethe-University Frankfurt, - - 2014
The association between vitamin D and multiple sclerosis has (re)-opened new interest in nutrition and natural compounds in the prevention and treatment of this neuroinflammatory disease. The dietary amount and type of fat, probiotics and biologicals, salmon proteoglycans, phytoestrogens and protease inhibitor of soy, sodium chloride and trace elements, and ...
Ortiz Genaro Gabriel GG Laboratorio Desarrollo-Envejecimiento, Enfermedades Neurodegenerativas, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México. Electronic address: - - 2014
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system associated with demyelination and axonal loss eventually leading to neurodegeneration. MS exhibits many of the hallmarks of an inflammatory autoimmune disorder including breakdown of the blood-brain barrier (BBB). The BBB is a complex organization of cerebral endothelial cells, ...
Howell Owain W OW Wolfson Neuroscience Laboratories, Centre for Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Imperial College London, UK; Neurology and Molecular Neuroscience, Institute of Life Science 1, College of Medicine, Swansea University, Swansea, SA2 8PP, - - 2014
Multiple Sclerosis (MS) is a progressive inflammatory neurological disease affecting myelin, neurons and glia. Demyelination and neurodegeneration of cortical grey matter contributes to a more severe disease and inflammation of the forebrain meninges associates with pathology of the underlying neocortical grey matter, particularly in deep sulci. We assessed the extent ...
Cheng Wenjing W Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai Institute of Immunology, PR - - 2014
Multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic neuroinflammatory autoimmune diseases characterized by axonal loss, demyelination and neurodegeneration of the central nervous system (CNS). Overactivation of CD4(+)T cells, especially the Th1 and Th17 subsets, is thought to play a causal role in this disease. In this ...
Karo-Atar Danielle D Tel-Aviv University. Sackler School of Medicine, - - 2014
Abstract Background: Macrophages are heterogeneous cells, which possess pleotropic effector and immunoregulatory functions. The phenotypic diversity of macrophages is best exemplified by the ability of IL-4 or IL-13, two key cytokines in asthma to promote macrophages into a suppressive/anti-inflammatory phenotype (e.g. alternatively activated or M2) whereas exposure to IFN-γ followed ...
Chan Elsa C EC Centre for Eye Research Australia, Department of Ophthalmology, University of Melbourne, Victoria, 3002, - - 2014
Systemic sclerosis is characterised by three main pathological features namely auto-immunity, vasculopathy and an overgrowth of connective tissues in the skin and visceral organs including lung, heart, kidney and gastrointestinal tract. Currently, there is no intervention directed towards fibrosis in systemic sclerosis. Blocking immune response with an immunosuppressive drug like ...
Thakur Krishan K KK Laboratory of Biotechnology, Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Gauhati Medical College, Guwahati-781032, Assam, - - 2014
Multiple Myeloma (MM) is a hematological malignancy characterized as an abnormal proliferation and invasion of plasma cells into the bone marrow. Toll-like receptors (ТLRs) connect the innate and adaptive immune responses and represent a significant and potentially linking element between inflammation and cancer. When TLRs bind to their ligands, they ...
Simon Anna - - 2014
A study in mice implicates a cholesterol derivative in damping down the inflammatory response mediated by interleukin-1β and explaining, at least in part, the immunosuppressive effect of type I interferon, which is used in the treatment of multiple sclerosis.
Dillingham Blythe C BC Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, 20010, - - 2014
Multiple sclerosis is a chronic disease of the central nervous system characterized by an autoimmune inflammatory reaction that leads to axonal demyelination and tissue damage. Glucocorticoids, such as prednisolone, are effective in the treatment of multiple sclerosis in large part due to their ability to inhibit pro-inflammatory pathways (e.g., NFκB). ...
Tanabe Shogo S Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita-shi, Osaka 565-0871, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, - - 2014
Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammation, demyelination, and neurodegeneration in the CNS. Although it is important to prevent neurodegeneration for alleviating neurological disability, the molecular mechanism of neurodegeneration remains largely unknown. Here, we report that repulsive guidance molecule-a (RGMa), known to regulate axonal growth, is ...
Cossu Davide D Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Sassari, - - 2014
A large number of reports indicate the association of Epstein-Barr virus (EBV), and Mycobacterium avium subsp. paratuberculosis (MAP) with multiple sclerosis (MS). To gain a better understanding of the role of these two pathogens, we investigated the host response induced by selected antigenic peptides. We examined both humoral and cell-mediated ...
Choi E Y EY 1] Department of Biomedical Sciences and Department of Pharmacology, Cell Dysfunction Research Center (CDRC), University of Ulsan College of Medicine, Seoul, Republic of Korea [2] Experimental Immunology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA [3] Department of Clinical Pathobiochemistry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany [4] Department of Internal Medicine III, Faculty of Medicine, Technische Universität Dresden, Dresden, - - 2014
Inflammation in the central nervous system (CNS) and disruption of its immune privilege are major contributors to the pathogenesis of multiple sclerosis (MS) and of its rodent counterpart, experimental autoimmune encephalomyelitis (EAE). We have previously identified developmental endothelial locus-1 (Del-1) as an endogenous anti-inflammatory factor, which inhibits integrin-dependent leukocyte adhesion. ...
Chalmin F F Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, 1211 Geneva 14, Switzerland; Department of Pathology and Immunology, University of Geneva, 1211 Geneva 4, - - 2014
Perturbation of steroids pathways is linked to inflammation and chronic diseases, however the underlying mechanism remains unclear. Oxysterols, oxidized forms of cholesterol, are not only essential for bile synthesis and sterol transportation but have recently been shown to contribute to the immune response. In addition, serum oxysterols levels have been ...
Arosio Daniela - - 2014
Dendritic Cells (DCs), the most potent antigen-presenting cells, play a critical role in the detection of invading pathogens, which are recognized also by multiple carbohydrate-specific receptors. Among them, DC-SIGN is one of the best characterized, with high-mannose and Lewis-type glycan specifity. In this study, we present a potent DC-SIGN targeting ...
Han X - - 2014
Atherosclerosis is primarily a disorder of lipid metabolism, but there is also a prominent chronic inflammatory component that drives the atherosclerotic lesion progression in the artery wall. During hyperlipidaemic conditions, there is a rapid influx of circulating monocytes into the atherosclerosis-prone areas of the arterial intima. These infiltrated monocytes differentiate ...
Ghaffarinia Ameneh A Department of Immunology, Medical School, Kermanshah University of Medical Sciences, Kermanshah, - - 2014
Multiple sclerosis is an inflammatory autoimmune disease of central nervous system (CNS) in which inflammatory cells release pro-inflammatory cytokines, proteases, and other toxic mediators. Proteases are involved in many aspects of inflammatory process. There are many reports regarding the effect of proteases on inflammation. Chymotrypsin is a serine protease with ...
Zhu Y Y University of Miami School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, Miami, Florida, - - 2014
Spinal cord injury (SCI) leads to formation of a fibrotic scar that is inhibitory to axon regeneration. Recent evidence indicates that the fibrotic scar is formed by perivascular fibroblasts, but the mechanism by which they are recruited to the injury site is unknown. Using bone marrow transplantation in mouse model ...
Zhang Rongwei R Department of Gerontology and Geriatrics, The First Affiliated Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, China, - - 2014
A number of different microRNAs (miRNAs) have been implicated in various autoimmune diseases, including multiple sclerosis (MS). T helper (Th)17 and regulatory T cells (Tregs) have likewise been implicated as key players in MS, and a functional imbalance of these cell types is increasingly recognized as a key etiological factor ...
Alvarez Jorge Ivan JI Neuroimmunology Unit, Department of Neurosciences, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Canada. Electronic address: - - 2014
Early changes in the normal appearing white matter of multiple sclerosis (MS) patients precede the appearance of gadolinium-enhancing lesions. Although these findings suggest blood-brain barrier (BBB) breakdown as an important feature in MS pathogenesis, limited information is available on the BBB alterations during lesion genesis. Here, we perform a longitudinal ...
Kale Sagar L SL Allergy and Immunology Section, CSIR-Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110007, India; Department of Biotechnology, University of Pune, Ganeshkhind, Pune 411007, - - 2014
Protease activity of Per a 10 has been shown to modulate dendritic cells toward Th-2 polarization and to induce airway inflammation. To elucidate the role of serine protease activity of Per a 10 in inducing biochemical responses in epithelial cells. Per a 10 was inactivated by heat treatment (ΔPer a ...
Meyers Lindsay L Research Service VAMC, Memphis, TN 38104, United - - 2014
Apolipoprotein A1 (Apo A-I), the most abundant component of high-density lipoprotein (HDL), is an anti-inflammatory molecule, yet its potential role in the pathogenesis of multiple sclerosis (MS) has not been fully investigated. In this study, Western blot analyses of human plasma showed differential Apo A-I expression in healthy controls compared ...
Jonas Anna - - 2014
In patients with multiple sclerosis (MS) and mice with experimental autoimmune encephalomyelitis (EAE), inflammatory axonal injury is a major determinant of disability; however, the drivers of this injury are incompletely understood. Here, we used the EAE model and determined that the extracellular matrix protein matrilin-2 (MATN2) is an endogenous neuronal ...
Praet Jelle J Experimental Cell Transplantation Group, Laboratory of Experimental Hematology, University of Antwerp, Antwerp, Belgium; Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium; BioImaging Laboratory, University of Antwerp, Antwerp, Belgium. Electronic address: - - 2014
The cuprizone mouse model allows the investigation of the complex molecular mechanisms behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is generally accepted that oligodendrocytes are specifically vulnerable to cuprizone intoxication due to their high metabolic demands, a comprehensive overview of the etiology of cuprizone-induced pathology is still missing to ...
Donders Raf - - 2014
Umbilical cord matrix or Wharton?s jelly-derived stromal cells (WJ-MSCs) are an easily accessible source of mesenchymal-like stem cells. Recent studies describe a hypo-immunogenic phenotype, multipotent differentiation potential and trophic support function for WJ-MSCs, with variable clinical benefit in degenerative disease models such as stroke, myocardial infarction and Parkinson?s disease. It ...
Liu Nan N Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, - - 2014
Immunological dysfunction is a primary characteristic of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been shown to ameliorate the clinical signs of EAE by suppressing the production of proinflammatory cytokines IFN-γ, TNF-α and ...
Kyrova Kamila - - 2014
BackgroundFollowing infection and initial multiplication in the gut lumen, Salmonella Typhimurium crosses the intestinal epithelial barrier and comes into contact with cells of the host immune system. Mononuclear phagocytes which comprise macrophages and dendritic cells (DC) are of key importance for the outcome of Salmonella infection. Although macrophages and DC ...
Pannee Chinjarernpan C Interdisciplinary Program of Pharmacology, Graduate School, Chulalongkorn University, Bangkok, - - 2014
Cassia oil (CO) from different parts of Cinnamomum cassia have different active components. Very few pharmacological properties of cassia leaf oil have been reported. This study investigated and compared effects of cassia leaf oil and cinnamaldehyde on lipopolysaccharide (LPS)-activated J774A.1 cells. Volatile compositions in cassia leaf oil were identified by ...
Wagner Verena V Max-Eder Group Experimental Therapies for Hematologic Malignancies, German Cancer Research Center (DKFZ) and Dept. of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. Contributed equally to this - - 2014
The inhibitor-of-apoptosis family member survivin has been reported to inhibit apoptosis and regulate mitosis and cytokinesis. In multiple myeloma, survivin has been described to be involved in downstream sequelae of various therapeutic agents. We assessed 1093 samples from previously untreated patients, including two independent cohorts of 392 and 701 patients, ...
Huber Amanda K AK From the Holtom-Garrett Program in Neuroimmunology and Multiple Sclerosis Center, Departments of Neurology (A.K.H., D.N.I., B.M.S.), Biostatistics (L.W.), and Radiology (A.S.), University of Michigan, Ann Arbor; Neurology Service (B.M.S.), VA Ann Arbor Healthcare System, MI; Department of Statistics and Actuarial Science (P.H.), University of Waterloo, Canada; Department of Mathematics and Statistics (X.Z.), Bowling Green State University, OH; and Department of Imaging Sciences (S.E.), University of Rochester Medical Center, - - 2014
In the current exploratory study, we longitudinally measured immune parameters in the blood of individuals with relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS), and investigated their relationship to disease duration and clinical and radiologic measures of CNS injury. Peripheral blood mononuclear cells (PBMCs) and plasma were obtained ...
Pakravan Nafiseh N Department of Microbiology and Immunology, Medical School, Alborz University of Medical Sciences, Karaj, - - 2014
Previous studies have shown that insemination elicits the expansion of the natural FoxP3(+) regulatory T cell (Treg) pool in female reproductive tissue during mating. Further research demonstrated that this effect was due to seminal vesicle fluid. Indeed, seminal vesicle fluid causes differential recruitment of Tregs into different organs. The recruitment ...
Thomas Katja K Departments of Neurology (K.T., T.S., H.R., T.Z.) and Dermatology (C.G.), University Hospital, Dresden; Institute of Immunology (K.D., R.W., M.S.), Medical Faculty, TU Dresden; Department of Neuropathology (I.M., W.B.), University Medical Centre, Göttingen; Department of Neurology (H.T.), University Hospital, Ulm; Department of Dermatology (K.S.), University Hospital, Heidelberg; and Center for Regenerative Therapies Dresden (M.S.), Dresden, - - 2014
To examine the potential role of 6-sulfo LacNAc(+) (slan) dendritic cells (DCs) displaying pronounced proinflammatory properties in the pathogenesis of multiple sclerosis (MS). We determined the presence of slanDCs in demyelinated brain lesions and CSF samples of patients with MS. In addition, we explored the impact of methylprednisolone, interferon-β, glatiramer ...
Slowik A A Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, - - 2014
The sphingosine 1-phosphate (S1P) receptor modulator is an approved treatment of relapsing multiple sclerosis (MS) because of its anti-inflammatory effect to retain lymphocytes within the lymph nodes. Here, we evaluated the potential of FTY720 (fingolimod; Gilenya™, Novartis Pharma AG) to activate pro-myelinating pathways within the brain to encourage remyelination and ...
Mayo Lior L Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Astrocytes have complex roles in health and disease, thus it is important to study the pathways that regulate their function. Here we report that lactosylceramide (LacCer) synthesized by β-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the central nervous system (CNS) of mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of ...
Abdin Amany A AA Departments of Pharmacology, Faculty of Medicine, Tanta University, Egypt. Electronic address: - - 2014
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of brain and spinal cord that has an increasing incidence worldwide and classically presents in a relapsing-remitting form. This study was designed to induce a relapsing-remitting model of experimental autoimmune encephalomyelitis (EAE) to investigate the possible modulatory effect of celastrol on ...
Zhou Xin X Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea; Department of Chemistry, Faculty of Science, Yanbian University, People's Republic of - - 2014
In the study described herein, the red emitting probe CHCN, which possesses a linked coumarin-hemicyanine scaffold, was developed for detection of peroxynitrite (ONOO(-)) under physiological conditions. The studies show that CHCN displays a dual ratiometric and colorimetric response to ONOO(-) that is caused by an oxidation process. A possible mechanism ...
Li Hong-Mei HM Faculty of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu, 233030, Anhui, - - 2014
Bioassay-guided fractionation of the MeOH extract of Magnolia grandiflora seeds resulted in the isolation of a new dimeric neolignan, named bishonokiol A (1), as well as two known neolignans magnolol (2) and honokiol (3). The structures of the compounds were determined on the basis of data obtained using NMR and ...
Liu Xiaomei X Nanjing Medical University, - - 2014
Interleukin 17 (IL-17), produced mainly by T helper (Th) 17 cells, is increasingly recognized as a key regulator in various autoimmune diseases, including human multiple sclerosis (MS), and its animal model, experimental autoimmune encephalomyelitis (EAE). Although several microRNAs (miRNAs) with aberrant expression have been shown to contribute to the pathogenesis ...
Panos Michael - - 2014
Abstract Recent studies provide a functional link between kallikrein 6 (Klk6) and the development and progression of disease in patients with multiple sclerosis (MS) and in its murine models. To evaluate the involvement of additional kallikrein family members, we compared Klk6 expression with four other kallikreins (Klk1, Klk7, Klk8, and ...
Russi Abigail E AE Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, - - 2014
The central nervous system (CNS) largely comprises nonregenerating cells, including neurons and myelin-producing oligodendrocytes, which are particularly vulnerable to immune cell-mediated damage. To protect the CNS, mechanisms exist that normally restrict the transit of peripheral immune cells into the brain and spinal cord, conferring an "immune-specialized" status. Thus, there has ...
Anthony Daniel C DC Department of Pharmacology, University of Oxford Mansfield Road, Oxford, OX1 3QT, United - - 2014
The mechanism of action of anti-B cell therapy in multiple sclerosis (MS) is not fully understood. Here, we compared the effect of anti-CD20 therapy on microglial activation in two distinct focal rat models of MS. The effect of anti-CD20 therapy on lesion formation and extralesional microglial activation was evaluated in ...
Hussain Rehana Z RZ Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, TX, - - 2014
Treatment of central nervous system (CNS) autoimmune disorders frequently involves the reduction, or depletion of immune-competent cells. Alternatively, immune cells are being sequestered away from the target organ by interfering with their movement from secondary lymphoid organs, or their migration into tissues. These therapeutic strategies have been successful in multiple ...
Lassmann H H Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Wien, Austria. Electronic address: - - 2014
Basic mechanisms of immune surveillance of the central nervous system (CNS) and of brain inflammation have recently been elucidated through neuroimmunological research. Despite this progress our understanding of human inflammatory diseases of the brain and spinal cord is still incomplete. In this short review, we discuss some recent findings on ...
He Yi-Xin - - 2014
Radix Astragali is famous for its beneficial effect on inflammation associated diseases. This study was to assess the efficacy of astragalosides (AST) extracted from Radix Astragali, on the progression of experimental autoimmune encephalomyelitis (EAE), and explore its possible underlying molecular mechanisms. EAE was induced by subcutaneous immunization of MOG35-55. Infiltration ...
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