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Hrusch Cara L CL Committee on Immunology, University of Chicago, Chicago, IL, - - 2015
Promoting tolerance to inhaled antigens is an active area of study with the potential to benefit the millions of Americans currently suffering from respiratory allergies and asthma. Interestingly, not all individuals with atopy are symptomatic, arguing that sensitization alone does not lead to an allergic clinical phenotype. Respiratory dendritic cells ...
Fonseca Denise Morais da DM Departments of Biochemistry and Immunology, University of São Paulo, Ribeirão Preto, - - 2014
We have shown that mycobacterial antigens and CpG oligodeoxynucleotides down modulate airway allergic inflammation by mechanisms dependent on T cell activation. Here we investigated the participation of the innate response, particularly the role of MyD88 adaptor, and Fas molecules in the effectiveness of DNA-HSP65 or CpG/CFP immunotherapy. Mice sensitized and ...
Pawankar Ruby R Department of Pediatrics, Nippon Medical School, Tokyo, - - 2014
Cytokines are immunomodulatory proteins important in cell signaling. Complex interactions of innate and adaptive immune cells, as well as structural cells and their cytokines, play crucial roles in regulating allergic airway inflammation. Here, we summarize current knowledge about the potential roles of known and newly identified helper T cells and ...
Divekar Rohit R Division of Allergic Diseases, Mayo Clinic, Rochester, Minnesota, - - 2014
Allergic diseases are thought to be driven by aberrant immune responses. Epithelium responds to various environmental factors by releasing key cytokines, such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25. Although there are important differences among these cytokines, there are also similarities which confound a clear understanding of the exact ...
Pérez-Novo Claudina A CA Upper Airways Research Laboratory, Department of Otolaryngology, Ghent University Hospital, Ghent, - - 2014
DNA methylation is an epigenetic mechanism that has been implicated in the pathogenesis of chronic inflammatory diseases by regulating differentiation, proliferation, apoptosis, and activation of immune cells. Changes in the methylation status of relevant genes have been linked to the origin, perpetuation, and severity of airway diseases. The DNA methylation ...
Karra L L Pharmacology Unit, The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, - - 2014
Chronic mucosal inflammation is the hallmark of important and common airway diseases, such as allergic rhinitis (AR) and asthma. Lipoxin A4 (LXA4) is an endogenous pro-resolving mediator for mucosal inflammation that decreases allergic and asthmatic responses. Lipoxin B4 (LXB4) is a structurally distinct member of the lipoxin family that signals ...
McAlees J W JW Division of Immunobiology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, - - 2014
Allergic asthma is a chronic, inflammatory lung disease. Some forms of allergic asthma are characterized by T helper type 2 (Th2)-driven eosinophilia, whereas others are distinguished by Th17-driven neutrophilia. Stimulation of Toll-like receptor 4 (TLR4) on hematopoietic and airway epithelial cells (AECs) contributes to the inflammatory response to lipopolysaccharide (LPS) ...
Doherty Taylor A TA Department of Medicine, University of California San Diego, La Jolla, California, USA - - 2014
The conventional paradigm of type 2 inflammatory responses is characterized by activation of CD4(+) Th2 cells that produce IL-4, IL-5, and IL-13, resulting in tissue eosinophil infiltration, mucus metaplasia, AHR, and IgE production. However, the recent discovery of ILC2s in mice and humans has brought forth a novel pathway in ...
Jongejan Laurian L Department of Experimental Immunology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands, - - 2014
Allergen-specific immunotherapy is the only treatment of allergic diseases that aims at modifying the underlying immune mechanism. Current protocols are long and at risk of anaphylactic reactions. The main aim of current research is decreasing the risk of side effects and increasing efficacy, in particular targeting reduction of treatment duration. ...
Navarro S S IPMC, CNRS UMR7275, INSERM U1080 Université de Nice-Sophia Antipolis, Valbonne, - - 2014
Allergic asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), lung infiltration of Th2 cells, and high levels of IgE. To date, allergen-specific immunotherapy (SIT) is the only treatment that effectively alleviates clinical symptoms and has a long-term effect after termination. Unfortunately, SIT is unsuitable for plurisensitized patients, ...
Muhammad Khan Asad A Department of Pharmacology, University of Health Sciences , Lahore , Pakistan - - 2014
Abstract Context: Ginger has been used commonly in the traditional system of medicine for the treatment of respiratory disorders. Objective: The present study investigates the immunosuppressive activity of ginger by using the mouse model of ovalbumin-induced allergic asthma. Materials and methods: Treatment with ethanol extract (500 mg/kg) and aqueous extract (720 mg/kg) ...
Scanlon S T ST MRC Laboratory of Molecular Biology, Protein & Nucleic Acid Chemistry (PNAC) Division, Cambridge University, Francis Crick Avenue, Cambridge, CB2 0QH, - - 2014
Although type-2 immune responses evolved primarily to defend against extracellular helminths, in part through the co-opting of tissue repair and remodelling mechanisms, it is often inappropriately directed towards relatively innocuous allergens resulting in conditions including asthma, allergic rhinitis, food allergy, and atopic dermatitis. The recent discovery of group 2 innate ...
Cheng Laurence E LE Department of Pediatrics, University of California, San Francisco, San Francisco, California - - 2014
Allergic inflammation is associated closely with parasite infection but also asthma and other common allergic diseases. Despite the engagement of similar immunologic pathways, parasitized individuals often show no outward manifestations of allergic disease. In this perspective, we present the thesis that allergic inflammatory responses play a primary role in regulating ...
Gershwin Laurel J LJ School of Veterinary Medicine, University of California, Davis, CA 95616; email: - - 2014
Allergic responses occur in humans, rodents, non-human primates, avian species, and all of the domestic animals. These responses are mediated by immunoglobulin E (IgE) antibodies that bind to mast cells and cause release/synthesis of potent mediators. Clinical syndromes include naturally occurring asthma in humans and cats; atopic dermatitis in humans, ...
Popov Aleksandrov Aleksandra A Department of Ecology, Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, - - 2014
Genetic factors are among the most important determinants of susceptibility to induction of allergic contact dermatitis. A limited number of studies of experimental contact hypersensitivity (CHS) in animals has shown differences in the severity of CHS; however, the underlying mechanisms are unknown. In this study comparative analysis of CHS to ...
Shin Yong-Kyu YK Department of Microbiology, Kyungpook National University, Daegu 702-701, Republic of - - 2014
In order to evaluate whether the aqueous fraction of Cinnamomum cassia produced by solid‑state fermentation with Phellinus baumii (afCc/Pb) inhibits atopic symptoms in vivo, its efficacy was evaluated in an animal model of 2,4‑dinitrofluorobenzene (DNFB)‑induced atopic dermatitis. Immune‑related cells were quantified using hematoxylin and eosin staining, and phenotypic cytokines, enzymes and ...
Zhang Fang F Department of Pulmonary Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China. Electronic address: - - 2014
High mobility group box chromosomal protein 1 (HMGB1) is a critical pro-inflammatory cytokine involved in diverse inflammatory diseases and has important immunomodulatory effects on allergic asthma. Our recent studies demonstrate that HMGB1 expression increases in the lung tissue and associates with interleukin-17(+) (IL-17) helper T cell (Th17) responses in a ...
Papazian Dick D Department of Cancer & Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; ALK, Hørsholm, - - 2014
The prevalence of allergic diseases such as allergic rhinitis is increasing, affecting up to 30% of the human population worldwide. Allergic sensitization arises from complex interactions between environmental exposures and genetic susceptibility, resulting in inflammatory T helper 2 (Th2) cell derived immune responses towards environmental allergens. Emerging evidence now suggest ...
Wu Chia-Ta CT Department of Emergency Medicine, Changhua Christian Hospital, Changhua, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, - - 2014
Asthma is a common allergic disease. In previous studies, probiotics improved the balance of intestinal microbes, reduced inflammation, and promoted mucosal tolerance. This study investigated whether oral administrations of Lactobacillus rhamnosus GG (LGG) inhibited allergen (ovalbumin or OVA)-induced airway inflammation in a mouse asthma model. The allergy/asthma animal model in ...
Ji Xiaotong X College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, PR - - 2014
Nitrogen dioxide (NO2) is an air pollutant associated with poor respiratory health, asthma exacerbation, and an increased likelihood of inhalational allergies. However, the underlying mechanisms are not clear. In the present study, the airway inflammatory response was first assessed in rats exposed to 5mg/m(3) NO2 for seven days. The results ...
Berger Marieke M Department of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Department of Respiratory Medicine, Spaarne Hospital, Hoofddorp, The - - 2014
House dust contains mite allergens as well as bacterial products like lipopolysaccharide (LPS). Asthma exacerbations are associated with the level of exposure to allergens and LPS. LPS can potentiate allergen effects in steroid-naïve patients. Long-acting β2-agonists (LABA) were shown to inhibit LPS-induced bronchial inflammation in healthy volunteers. The aim of ...
Vo Thanh-Sang TS Marine Bioprocess Research Center, Pukyong National University, Busan, 608-739, Republic of - - 2014
Marine polysaccharides have been found as the principle component in cell wall structures of seaweeds or exoskeletons of crustaceans. Due to numerous pharmaceutical properties of marine polysaccharides such as antioxidant, anti-inflammatory, anti-allergic, anti-tumor, anti-obesity, anti-diabetes, anti-coagulant, anti-viral, immunomodulatory, cardioprotective, and anti-hepatopathy activities, they have been applied in many fields of ...
Gela Anele A Respiratory Medicine & Allergology, Karolinska Institutet, Stockholm, - - 2014
During bacterial infections of the airways, a Th1-profiled inflammation promotes the production of several host defense proteins and peptides with antibacterial activities including β-defensins, ELR-negative CXC-chemokines, and the cathelicidin LL-37. These are down-regulated by Th2 cytokines of the allergic response. Instead, the eosinophil-recruiting chemokines eotaxin-1/CCL11, eotaxin-2/CCL24, and eotaxin-3/CCL26 are expressed. ...
Baiula Monica - - 2014
Glucocorticoids are used to treat chronic and severe forms of allergic conjunctivitis. Although they exert a rapid and powerful therapeutic activity, relevant side effects may limit their ocular use: increase of intraocular pressure, cataract formation and reduced resistance to infections. New glucocorticoids displaying the same potency of classical glucocorticoids but ...
Rosenstein Rachel K RK Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT - - 2014
Allergic diseases represent a significant burden in industrialized countries, but why and how the immune system responds to allergens remain largely unknown. Because many clinically significant allergens have proteolytic activity, and many helminths express proteases that are necessary for their life cycles, host mechanisms likely have evolved to detect the ...
Ghosh Sumit - - 2014
Sensitization to fungi often leads to a severe form of asthma that is particularly difficult to manage clinically, resulting in increased morbidity and hospitalizations in these patients. Although B lymphocytes might exacerbate asthma symptoms through the production of IgE, these cells might also be important in the protective response against ...
Han Hongwei - - 2014
Atopic dermatitis (AD) and food allergy are closely linked; however, the mechanisms that guide the progression of AD to allergic inflammatory responses at other mucosal surfaces, including the gastrointestinal tract, are not well understood. Here, we determined that exposure of mice that have been epicutaneously sensitized with thymic stromal lymphopoietin ...
Wang Yong Y Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, - - 2014
Cigarette smoking enhances oxidative stress and airway inflammation in asthma, the mechanisms of which are largely unknown. Myeloid-derived regulatory cells (MDRC) are free radical producing immature myeloid cells with immunoregulatory properties that have recently been demonstrated as critical regulators of allergic airway inflammation. NO (nitric oxide)-producing immunosuppressive MDRC suppress T-cell ...
Simpson Laura J LJ Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, California, - - 2014
MicroRNAs (miRNAs) exert powerful effects on immunological function by tuning networks of target genes that orchestrate cell activity. We sought to identify miRNAs and miRNA-regulated pathways that control the type 2 helper T cell (TH2 cell) responses that drive pathogenic inflammation in asthma. Profiling miRNA expression in human airway-infiltrating T ...
Soyka Michael B - - 2014
Allergen-specific immunotherapy (AIT) was described as a therapeutic option for the treatment of allergies > 100 years ago. It is based on administration of allergen extracts and leads to the development of clinical allergen tolerance in selected patients. According to current knowledge, AIT results in the restoration of immune tolerance ...
Madonini Enzo R ER Allergopharma S.p.A. Scientific Direction; Via C. Porta - Residenza Bosco 833, 20080 Basiglio (MI) Phone: +39 335 52 62 740 E-mail: enzo.madonini@gmail.com - - 2014
During the last years, along with the growing knowledge about the role and importance of the intestinal flora, interest remarkably increased in probiotic bacteria supplementation. It has indeed been demonstrated that the intestinal microbiota is very important in the regulation of several functions of the organism, even those far from ...
Chapman Aaron M AM David Geffen School of Medicine at UCLA Departments of Molecular Toxicology Los Angeles, - - 2014
Asthma is a common heterogeneous disease with both genetic and environmental factors that affects millions of individuals worldwide. Activated type 2 helper T cells secrete a panel of cytokines, including IL-13, a central immune regulator of many of the hallmark type 2 disease characteristics found in asthma. IL-13 has been ...
Miller Rachel L RL Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY. Electronic address: - - 2014
Despite attempts and some successes to improve air quality over the decades, current US national trends suggest that exposure to outdoor and indoor air pollution remains a significant risk factor for both the development of asthma and the triggering of asthma symptoms. Emerging science also suggests that environmental exposures during ...
Lee Yong Gyu YG The Ohio State University, Pulmonary, Allergy, Critical Care and Sleep, Columbus, Ohio, United - - 2014
Rationale: Although alveolar macrophages (AM) from asthmatics are known to be functionally different than those of healthy individuals, the mechanism by which this transformation occurs has not been fully elucidated in asthma. Objective: To define the mechanism(s) that controls AM phenotypic and functional transformation in response to acute allergic airway ...
Kato Go - - 2014
BackgroundLong-acting ß2 adrenergic agonists (LABAs) are commonly used combined with inhaled corticosteroids (ICS) to treat asthmatic patients. Previous reports suggest that LABAs have an anti-inflammatory effect in bronchial asthma, and this should be further investigated. The aim of this study was to investigate whether LABAs inhibit allergic airway inflammation and ...
Bernink Jochem H JH Department of Cell Biology & Histology, Academic Medical Center at the University of Amsterdam, - - 2014
Group 2 innate lymphoid cells (ILC2) which are strategically interspersed throughout barrier surfaces are important regulators of type 2 immune reactions, particularly against helminthic parasites. ILC2 are also involved in tissue homeostasis and repair. Studies in a variety of animal models have demonstrated that when dysregulated or chronically activated, ILC2 ...
Engelke Carsten C Institute for Systemic Inflammation Research, University of Lübeck and Airway Research Center North, member of the German Center for Lung Research, 23538 Lübeck, - - 2014
Conventional dendritic cells (cDC) are necessary and sufficient to drive mixed maladaptive Th2/Th17 immune responses toward aeroallergens in experimental allergy models. Previous studies suggest that the anaphylatoxin C3a promotes, whereas C5a protects from the development of maladaptive immunity during allergen sensitization. However, only limited evidence exists that such effects are ...
Martin Stefan F SF Allergy Research Group, Department of Dermatology, Medical Centre - University of Freiburg, Hauptstrasse 7, D-79104, Freiburg, - - 2014
Allergic contact dermatitis affects a worrying proportion of the general population. The mechanisms underlying this chemical-triggered delayed-type hypersensitivity are still not fully understood. In recent years, basic research has shown that the immune system reacts to contact allergens by activation of signalling pathways that are usually used to fight infections. ...
Jackson David J DJ Imperial College London, National Heart and Lung Institute, London, United Kingdom ; - - 2014
Rationale: Rhinoviruses are the major cause of asthma exacerbations, however mechanisms are poorly understood. We hypothesised that the epithelial-derived cytokine IL-33 plays a central role in exacerbation pathogenesis through augmentation of type 2 inflammation. Objectives: To assess whether rhinovirus induces a type 2 inflammatory response in asthma in vivo and ...
Lin Pin-Yi PY Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, Taipei, - - 2014
T helper (Th) 2 cells, which produce IL-4, IL-5, and IL-13, control immunity to all forms of allergic inflammatory responses. IL-21 reduces allergic symptoms in murine models and inhibits IL-4-induced IgE secretion by B cells. However, whether or not IL-21 directly affects Th2 cells which leads to reduced allergic symptoms ...
Je In-Gyu IG CMRI, BK21 Plus KNU Biomedical Convergence Program, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of - - 2014
In this study, we investigated the effect of 3,4,5-trihydroxy-N-(8-hydroxyquinolin-2-yl)benzamide) (SG-HQ2), a synthetic analogue of gallic acid (3,4,5-trihydroxybenzoic acid), on the mast cell-mediated allergic inflammation and the possible mechanism of action. Mast cells play major roles in immunoglobulin E-mediated allergic responses by the release of histamine, lipid-derived mediators, and pro-inflammatory cytokines. ...
Asai-Tajiri Yukari - - 2014
BackgroundCD86-CD28 interaction has been suggested as the principal costimulatory pathway for the activation and differentiation of naïve T cells in allergic inflammation. However, it remains uncertain whether this pathway also has an essential role in the effector phase. We sought to determine the contribution of CD86 on dendritic cells in ...
Brandelius Angelica A Unit of Respiratory Immunopharmacology, Dept. Experimental Medical Science, Lund University, - - 2014
Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in ...
Wei Hongqi H Department of Otolaryngology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, - - 2014
Staphylococcal enterotoxin (SE) induces T lymphocyte activation along with nasal allergic inflammation during rhinosinusitis, but it is under debate on which types of T helper (Th) cells respond exclusively or whether they respond synergically. We hypothesize that their responses may vary based on dose of SE. To test this hypothesis, ...
Vogel Elizabeth R ER Mayo - - 2014
Cigarette smoke is a common environmental insult associated with increased risk of developing airway diseases such as wheezing and asthma in neonates and children. In adults, asthma involves airway remodeling characterized by increased airway smooth muscle (ASM) cell proliferation and increased extracellular matrix (ECM) deposition, as well as airway hyperreactivity. ...
Gupta Anukriti A Department of Oral Biology, Rutgers School of Dental Medicine, Newark, New Jersey, USA; Departments of - - 2014
Allergic asthma is a chronic respiratory disease that results from an exaggerated inflammatory response in the airways. Environment stimuli, such as pollen and HDM, cause activation and migration of inflammatory WBCs into the respiratory tract, where they cause lung damage. Migration of these WBCs is dependent on the active configuration ...
Kaur Manminder M University of Manchester, Institute of Inflammation and Repair, University Hospital of South Manchester Foundation Trust, Southmoor Road, Manchester M23 9LT, UK. Electronic address: - - 2014
Lymphocytes play a central role in the pathophysiology of asthma. Corticosteroids have a limited effect in severe asthma and we hypothesise that lymphocytes play a central role in corticosteroid insensitivity. We investigated the effects of corticosteroids on cytokine production from lung lymphocytes obtained from patients with moderate severe asthma (MSA) ...
Mathie Sara A SA Leukocyte Biology, NHLI, Faculty of Medicine, Imperial College London, SW7 2AZ, - - 2014
Alveolar macrophages are sentinels of the pulmonary mucosa and central to maintaining immunological homeostasis. However, their role in governing the response to allergen is not fully understood. Inappropriate responses to the inhaled environment manifest as asthma. We utilised a mechanistic IL-13 driven model and a house dust mite allergen mucosal ...
Bleier Benjamin S BS Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, - - 2014
Verapamil is an L-type calcium channel blocker (CCB) that has been shown to have immunomodulatory properties in a variety of tissues. The goal of this study was determine whether verapamil is capable of regulating cytokine secretion in sinonasal polyps and to compare this effect to dexamethasone, an established immunosuppressive corticosteroid. ...
Jang Hyun-Young HY Departments of Biochemistry National University Medical School, Jeonju, Jeonbuk 561-756, Republic of - - 2014
In recent studies, SPA0355, a thiourea analog, has been demonstrated to possess strong anti-inflammatory activity. However, the mechanisms underlying the effects of SPA0355 on immune-mediated diseases have not been fully defined. The present study was designed to investigate the immunological and molecular mechanisms by which SPA0355 modulates cluster of differentiation ...
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