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Jongejan Laurian L Department of Experimental Immunology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands, - - 2014
Allergen-specific immunotherapy is the only treatment of allergic diseases that aims at modifying the underlying immune mechanism. Current protocols are long and at risk of anaphylactic reactions. The main aim of current research is decreasing the risk of side effects and increasing efficacy, in particular targeting reduction of treatment duration. ...
Martin Stefan F SF Allergy Research Group, Department of Dermatology, Medical Centre - University of Freiburg, Hauptstrasse 7, D-79104, Freiburg, - - 2014
Allergic contact dermatitis affects a worrying proportion of the general population. The mechanisms underlying this chemical-triggered delayed-type hypersensitivity are still not fully understood. In recent years, basic research has shown that the immune system reacts to contact allergens by activation of signalling pathways that are usually used to fight infections. ...
Jackson David J DJ Imperial College London, National Heart and Lung Institute, London, United Kingdom ; - - 2014
Rationale: Rhinoviruses are the major cause of asthma exacerbations, however mechanisms are poorly understood. We hypothesised that the epithelial-derived cytokine IL-33 plays a central role in exacerbation pathogenesis through augmentation of type 2 inflammation. Objectives: To assess whether rhinovirus induces a type 2 inflammatory response in asthma in vivo and ...
Lin Pin-Yi PY Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, Taipei, - - 2014
T helper (Th) 2 cells, which produce IL-4, IL-5, and IL-13, control immunity to all forms of allergic inflammatory responses. IL-21 reduces allergic symptoms in murine models and inhibits IL-4-induced IgE secretion by B cells. However, whether or not IL-21 directly affects Th2 cells which leads to reduced allergic symptoms ...
Asai-Tajiri Yukari - - 2014
BackgroundCD86-CD28 interaction has been suggested as the principal costimulatory pathway for the activation and differentiation of naïve T cells in allergic inflammation. However, it remains uncertain whether this pathway also has an essential role in the effector phase. We sought to determine the contribution of CD86 on dendritic cells in ...
Je In-Gyu IG CMRI, BK21 Plus KNU Biomedical Convergence Program, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of - - 2014
In this study, we investigated the effect of 3,4,5-trihydroxy-N-(8-hydroxyquinolin-2-yl)benzamide) (SG-HQ2), a synthetic analogue of gallic acid (3,4,5-trihydroxybenzoic acid), on the mast cell-mediated allergic inflammation and the possible mechanism of action. Mast cells play major roles in immunoglobulin E-mediated allergic responses by the release of histamine, lipid-derived mediators, and pro-inflammatory cytokines. ...
Vogel Elizabeth R ER Mayo - - 2014
Cigarette smoke is a common environmental insult associated with increased risk of developing airway diseases such as wheezing and asthma in neonates and children. In adults, asthma involves airway remodeling characterized by increased airway smooth muscle (ASM) cell proliferation and increased extracellular matrix (ECM) deposition, as well as airway hyperreactivity. ...
Gupta Anukriti A Department of Oral Biology, Rutgers School of Dental Medicine, Newark, New Jersey, USA; Departments of - - 2014
Allergic asthma is a chronic respiratory disease that results from an exaggerated inflammatory response in the airways. Environment stimuli, such as pollen and HDM, cause activation and migration of inflammatory WBCs into the respiratory tract, where they cause lung damage. Migration of these WBCs is dependent on the active configuration ...
Mathie Sara A SA Leukocyte Biology, NHLI, Faculty of Medicine, Imperial College London, SW7 2AZ, - - 2014
Alveolar macrophages are sentinels of the pulmonary mucosa and central to maintaining immunological homeostasis. However, their role in governing the response to allergen is not fully understood. Inappropriate responses to the inhaled environment manifest as asthma. We utilised a mechanistic IL-13 driven model and a house dust mite allergen mucosal ...
Bleier Benjamin S BS Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, - - 2014
Verapamil is an L-type calcium channel blocker (CCB) that has been shown to have immunomodulatory properties in a variety of tissues. The goal of this study was determine whether verapamil is capable of regulating cytokine secretion in sinonasal polyps and to compare this effect to dexamethasone, an established immunosuppressive corticosteroid. ...
Rydman Elina M - - 2014
BackgroundCarbon nanotubes (CNT) represent a great promise for technological and industrial development but serious concerns on their health effects have also emerged. Rod-shaped CNT are, in fact, able to induce asbestos-like pathogenicity in mice including granuloma formation in abdominal cavity and sub-pleural fibrosis. Exposure to CNT, especially in the occupational ...
Huang Jing J School of Pharmacy, Heath Science Center Xi'an Jiaotong University, 76#, Yanta Westroad, Xi'an, 710061, - - 2014
Allergy is an abnormal immune response to an allergen. Type I hypersensitivity is an immunoglobulin (Ig) E-mediated allergic disorder. Fructus piperis is derived from the ripe fruit of the pepper, which is widely used as a spice in human diets and is also administered as a medicine in many countries. ...
Cho Min Kyoung MK Department of Parasitology, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam-do, 626-870, Republic of - - 2014
Anisakis (Anisakidae) is one of the most important causes of helminth-induced allergic reactions and elicits clinical responses that include urticaria, rhinitis, bronco-constriction, cough, and/or gastrointestinal symptoms. More than 13 reactive allergens have been identified in the serum of Anisakis allergy patients, but the allergenicity of only a few of these ...
Yoo Young Y Department of Pediatrics, College of Medicine, Korea University, Seoul, South - - 2014
The prevalence of asthma and other allergic diseases is still increasing both in developed and developing countries. Allergic sensitization against common inhalant allergens is common and, although not sufficient, a necessary step in the development of allergic diseases. Despite a small number of proteins from certain plants and animals being ...
Legatzki Antje A Dr von Hauner Children's Hospital, Ludwig Maximilian University, Lindwurmstrasse 4, 80337, Munich, Germany, - - 2014
The prevalence of asthma and allergy has been constantly increasing in Westernized countries in the last decades. Asthma and allergies are complex diseases with a local tissue inflammation that are determined by genetic and environmental factors. Because the commensal microflora is crucial to maintain inflammatory homeostasis and to induce immune ...
Beale Janine J Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, London W2 1PG, UK. Medical Research Council (MRC) and Asthma UK Centre in Allergic Mechanisms of Asthma, London W2 1PG, UK. Centre for Respiratory Infection, Imperial College London, London W2 1PG, - - 2014
Rhinoviruses (RVs), which are the most common cause of virally induced asthma exacerbations, account for much of the burden of asthma in terms of morbidity, mortality, and associated cost. Interleukin-25 (IL-25) activates type 2-driven inflammation and is therefore potentially important in virally induced asthma exacerbations. To investigate this, we examined ...
Pillai Meenu R MR Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, - - 2014
The JmjC protein Mina is an important immune response regulator. Classical forward genetics first discovered its immune role in 2009 in connection with the development of T helper 2 (Th2) cells. This prompted investigation into Mina's role in the two best-studied contexts where Th2 responses are essential: atopic asthma and ...
Arrieta Marie-Claire MC Michael Smith Laboratories, 301 - 2185 East Mall, University of British Columbia, Vancouver, BC, Canada V6T - - 2014
There is increasing evidence that environmental changes are involved in the sharp increase in asthma incidence, as well as with other immune-mediated diseases. This increase matches the introduction of modern life advances such as antibiotics and caesarean sections. Several epidemiological studies provide convincing evidence that a lack of exposure to ...
Fyhrquist Nanna N Unit of Systems Toxicology, Finnish Institute of Occupational Health, Helsinki, - - 2014
The human commensal microbiota interacts in a complex manner with the immune system, and the outcome of these interactions might depend on the immune status of the subject. Previous studies have suggested a strong allergy-protective effect for Gammaproteobacteria. Here we analyze the skin microbiota, allergic sensitization (atopy), and immune function ...
Gil Malgorzata A MA Pharmacology, Merck Research Laboratories, Boston, MA, USA - - 2014
Alternaria alternata is a fungal allergen linked to the development of severe asthma in humans. In view of the clinical relationship between A. alternata and asthma, we sought to investigate the allergic activity of this antigen after direct application to the lungs of Brown Norway rats. Here we demonstrate that ...
Platzer B B Division of Gastroenterology and Nutrition, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, - - 2014
Antigen-mediated cross-linking of Immunoglobulin E (IgE) bound to mast cells/basophils via FcɛRI, the high affinity IgE Fc-receptor, is a well-known trigger of allergy. In humans, but not mice, dendritic cells (DCs) also express FcɛRI that is constitutively occupied with IgE. In contrast to mast cells/basophils, the consequences of IgE/FcɛRI signals ...
Fulkerson Patricia C PC Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH - - 2014
Eosinophils originate in the bone marrow from an eosinophil lineage-committed, IL-5Rα-positive, hematopoietic progenitor (eosinophil progenitor). Indeed, IL-5 is recognized as a critical regulator of eosinophilia and has effects on eosinophil progenitors, eosinophil precursors, and mature eosinophils. However, substantial levels of eosinophils remain after IL-5 neutralization or genetic deletion, suggesting that ...
Walford Hannah H HH Department of Medicine, University of California-San Diego, San Diego, CA, USA; Rady's Children's Hospital of San Diego, Division of Rheumatology, Allergy and Immunology, San Diego, CA, - - 2014
Type 2 innate lymphoid cells (ILC2s) have recently been identified in human nasal polyps, but whether numbers of ILC2s differ by polyp endotype or are influenced by corticosteroid use is unknown. Here, we show that eosinophilic nasal polyps contained double the number of ILC2s vs. non-eosinophilic polyps. Polyp ILC2s were ...
Zasłona Zbigniew Z Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI - - 2014
The role and origin of alveolar macrophages (AMs) in asthma are incompletely defined. We sought to clarify these issues in the context of acute allergic lung inflammation using house dust mite and OVA murine models. Use of liposomal clodronate to deplete resident AMs (rAMs) resulted in increased levels of inflammatory ...
Kumar Rakesh K RK Department of Pathology, School of Medical Sciences, UNSW Australia, Sydney, - - 2014
Exposure to airborne particulate matter (PM) may promote development of childhood asthma and trigger acute exacerbations of existing asthma via injury to airway epithelial cells (AEC). We compared the response of AEC to ambient particulates with median aerodynamic diameters of <10 μm or <2.5 μm from the Sydney metropolitan region (Sydney PM10 ...
Raedler Diana D University Children's Hospital Munich, Department of Pulmonary & Allergy, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, - - 2014
Childhood asthma is classified into allergic asthma (AA) and nonallergic asthma (NA), yet both are treated identically, with only partial success. We sought to identify novel immune phenotypes for childhood AA and NA. The Clinical Asthma Research Association cohort study includes 275 steroid-naive 4- to 15-year-old German children (healthy control ...
Schaumann Frank - - 2014
BackgroundEpidemiological and experimental studies suggest that exposure to ultrafine particles (UFP) might aggravate the allergic inflammation of the lung in asthmatics.MethodsWe exposed 12 allergic asthmatics in two subgroups in a double-blinded randomized cross-over design, first to freshly generated ultrafine carbon particles (64 ¿g/m3; 6.1¿±¿0.4 × 105 particles/cm3 for 2 h) and then ...
Nabe Takeshi T Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, - - 2014
Interleukin (IL)-33, a member of the IL-1 family of cytokines, is produced when epithelial and endothelial cells are exposed to stimuli. Hematopoietic cells such as macrophages also produce IL-33. IL-33 is considered to function as an 'alarmin', activating various immune cells through its receptor ST2, which leads to the production ...
Miraglia Del Giudice Michele M Department of Pediatrics, Second University of Naples, Naples, - - 2014
Social and economic costs of allergic rhinitis (AR) are impressive; AR may also significantly impact school attendance and performance, quality of life, and sleep (1). The AR immunopathology is characterized by T-helper-2 (Th2)-dependent inflammation and Th1-response impairment. This imbalance is sustained by dysfunction of immune system: allergic patients are lacking ...
Eom Sangkyung S Kangwon National University, Korea, Republic - - 2014
The molecular mechanism of transglutaminase II (TGaseII)-mediated allergic inflammation remains largely unknown. TGaseII, induced by antigen stimulation, showed an interaction and co-localization with FcεRI. TGaseII was necessary for in vivo allergic inflammation, such as triphasic cutaneous reaction (TpCR), passive cutaneous anaphylaxis (PCA), and passive systemic anaphylaxis (PSA). TGaseII was necessary ...
Al-Alawi Mazen M Department of Respiratory Medicine, Mater Misericordiae Hospital, Eccles Street, Dublin 7, - - 2014
Asthma is a chronic inflammatory airway disease involving complex interplay between resident and infiltrative cells, which in turn are regulated by a wide range of host mediators. Identifying useful biomarkers correlating with clinical symptoms and degree of airway obstruction remain important to effective future asthma treatments. Transforming growth factor β ...
McGovern Toby K TK McGill University, Medicine, Montreal, Quebec, Canada ; - - 2014
ABSTRACT Rationale: Chlorine gas (Cl2) inhalation causes oxidative stress, airway epithelial damage, airway hyperresponsiveness (AHR) and neutrophilia. Objectives: We evaluated the effect of neutrophil depletion on Cl2-induced AHR, affect the endogenous anti-oxidant response and, if eosinophils or macrophages influence Cl2-induced AHR. Methods: We exposed male Balb/C to 100ppm Cl2 for ...
Guzmán Mauricio M Immunology, Institute of Experimental Medicine, National Academy of Medicine/CONICET, Pacheco de Melo 3081, Buenos Aires, C1425AUM, - - 2014
Purpose: To evaluate the role of nuclear factor kappa B (NF-κB) activation in eye drop preservative toxicity and the effect of topical NF-κB inhibitors on preservative-facilitated allergic conjunctivitis. Methods: Balb/c mice were instilled ovalbumin (OVA) combined with benzalkonium chloride (BAK) and/or NF-κB inhibitors in both eyes. After immunization, T cell ...
Sumpter Tina L TL Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, - - 2014
Efficient development of atopic diseases requires interactions between allergen and adjuvant to initiate and amplify the underlying inflammatory responses. Substance P (SP) and hemokinin-1 (HK-1) are neuropeptides that signal through the neurokinin-1 receptor (NK1R) to promote inflammation. Mast cells initiate the symptoms and tissue effects of atopic disorders, secreting TNF ...
Tian Bao-Ping BP Zhejiang University School of Medicine, Respiratory and Critical Care Medicine, Hangzhou, China ; - - 2014
Interleukin-17A (IL-17) is known to play important roles in immune and inflammatory disease such as in asthma, but its functions in allergic airway inflammation are still controversial, and the molecular mechanisms mediating these functions remain unclear. Increased production of eosinophils in bone marrow and their emergence in the airway have ...
Chen Shih-Ming SM a Graduate Institute of Clinical Medical Sciences, Chang Gung University, Tao-Yuan, - - 2014
Astragalus membranaceus, a traditional Chinese herb, has been used to improve airway inflammation and asthma. The present study investigated whether A. membranaceus has immunotherapeutic effects on asthma, a chronic inflammatory mucosal disease that is associated with excess production of IgE, eosinophilia, T helper 2 (Th2) cytokines, and bronchial hyperresponsiveness. An ...
Lambrecht Bart N BN Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium; Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium; Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands. Electronic address: - - 2014
Allergic sensitization to inhaled antigens is common but poorly understood. Although lung epithelial cells were initially merely regarded as a passive barrier impeding allergen penetrance, we now realize that they recognize allergens through expression of pattern recognition receptors and mount an innate immune response driven by activation of nuclear factor ...
Chesné J J INSERM UMR 1087, Institut du thorax, Nantes, Loire Atlantique, France, CNRS 6291, Nantes, Loire Atlantique, France, Université de Nantes, Nantes, Loire Atlantique, France ; - - 2014
Asthma is a major chronic disease ranging from mild to severe refractory disease and is classified into various clinical phenotypes. Severe asthma is difficult to treat and frequently requires high doses of systemic steroids. In some cases, severe asthma even responds poorly to steroids. Several studies have suggested a central ...
Hou Changchun - - 2014
The pro-inflammation factor high-mobility group box protein 1 (HMGB1) has been implicated in the pathogenesis of asthma. In this study, we used a murine model of chronic asthma to evaluate the effects of HMGB1 on airway remodeling. Female BALB/c mice were randomly divided into four groups: control, ovalbumin (OVA) asthmatic, ...
Murdoch Jenna R JR Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, UK, SW7 - - 2014
γδT cells play a crucial immunoregulatory role in the lung, maintaining normal airway tone and preventing hyperresponsiveness to innocuous allergen. During acute inflammatory episodes, γδT cells promote resolution of acute inflammation. However their contribution to inflammation associated airway remodelling remains unexplored. Here we investigate the effects of γδT cell blockade ...
Shin In-Sik IS Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea; College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of - - 2014
Asthma is a common chronic inflammatory airway disease that is recognized as a major public health problem. In this study, we evaluated the effects of melatonin on allergic asthma using a murine model of ovalbumin (OVA)-induced allergic asthma and BEAS-2B cells. To induce allergic asthma, the mice were sensitized and ...
Woo Yeonduk Y Laboratory of Immune Regulation, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-744, - - 2014
Asthma is a common pulmonary disease with several different forms. The most studied form of asthma is the allergic form, which is mainly related to the function of Th2 cells and their production of cytokines (IL-4, IL-5, and IL-13) in association with allergen sensitization and adaptive immunity. Recently, there have ...
Lee Hyun Jae HJ Department of Pharmacology, Chungnam National University School of Medicine, Daejeon, - - 2014
It is valuable to find the potential activity of regulating the excessive mucin secretion by the compounds derived from various medicinal plants. We investigated whether aqueous extract of the root bark of Morus alba L. (AMA), kuwanon E, kuwanon G, mulberrofuran G, and morusin significantly affect the secretion and production ...
Kim Hyung-Woo HW Division of Pharmacology, Department of Korean Medicine, School of Korean Medicine, Pusan National University, Busan 626-870, Republic of - - 2014
So-Cheong-Ryong-Tang (SCRT), herbal medicine, has been used for the control of respiratory disease in East Asian countries. However, its therapeutic mechanisms, especially an inhibitory effect on inflammatory cell infiltration and airway remodeling in allergic asthma are unclear. The present study investigated the mechanism of antiasthmatic effects of SCRT in allergic ...
Gamazo Carlos C University of Navarra Dept. Microbiology C/Irunlarrea, 1; 31080 - Pamplona, - - 2014
Allergic diseases are one of the most prevalent diseases, reaching epidemic proportions in developed countries. An allergic reaction occurs after contact with an environmental protein, such as inhalants allergens (pollen, animal dander, house dust mites), or food proteins. This response is known as part of the type 2 immunity that ...
MacRedmond Ruth E RE Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, - - 2014
The airway epithelium has a number of roles pivotal to the pathogenesis of asthma, including provision of a physical and immune barrier to the inhaled environment. Dysregulated injury and repair responses in asthma result in loss of airway epithelial integrity. Inhaled corticosteroids are a corner stone of asthma treatment. While ...
Cuppari Caterina C Department of Pediatrics, Unit of Pediatric Genetics & Immunology, University of Messina, - - 2014
Allergen immunotherapy is a disease-modifying therapy, effective for the treatment of allergic rhinitis, allergic asthma, conjunctivitis or stinging insect allergy. Allergen immunotherapy involves the administration of increasing doses of allergens with the aim of ameliorating the allergic response. Although precise underlying mechanisms of the induction of immune tolerance remain unclear, ...
Athari Seyyed Shamsadin SS Department of Immunology, Faculty of Medical Science, Tarbiat Modares University, Tehran, - - 2014
HBV is a non-cytopathic virus and cell mediated immune response against this. Humoral mediated immune response are responsible for allergic diseases. Balance between these two subsets of Th CD4+ cells are result of the immune system response. A 56 year old woman presented with chronic HBV infection, allergic asthma, type ...
Popescu Florin-Dan FD Florin-Dan Popescu, Department of Allergology, "Carol Davila" University of Medicine and Pharmacy, "Nicolae Malaxa" Clinical Hospital, Department of Allergology and Clinical Immunology, 022441 Bucharest, - - 2014
Grass pollen allergy represents a significant cause of allergic morbidity worldwide. Component-resolved diagnosis biomarkers are increasingly used in allergy practice in order to evaluate the sensitization to grass pollen allergens, allowing the clinician to confirm genuine sensitization to the corresponding allergen plant sources and supporting an accurate prescription of allergy ...
Moreira Flavio Tocci FT Department of Medicine, Federal University of São Paulo, Sao Paulo, SP, - - 2014
To compare the effects of two of the most effective lipid-lowering therapies with similar LDL-cholesterol reduction capacity on the innate and adaptive immune responses through the evaluation of autoantibodies anti- oxidized LDL (anti-oxLDL Abs) and electronegative LDL [LDL(-)] levels. We performed a prospective, randomized, open label study, with parallel arms ...
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