Search Results
Results 1 - 50 of 1609
1 2 3 4 5 6 7 8 9 10 >
Yoo Young Y Department of Pediatrics, College of Medicine, Korea University, Seoul, South - - 2014
The prevalence of asthma and other allergic diseases is still increasing both in developed and developing countries. Allergic sensitization against common inhalant allergens is common and, although not sufficient, a necessary step in the development of allergic diseases. Despite a small number of proteins from certain plants and animals being ...
Legatzki Antje A Dr von Hauner Children's Hospital, Ludwig Maximilian University, Lindwurmstrasse 4, 80337, Munich, Germany, - - 2014
The prevalence of asthma and allergy has been constantly increasing in Westernized countries in the last decades. Asthma and allergies are complex diseases with a local tissue inflammation that are determined by genetic and environmental factors. Because the commensal microflora is crucial to maintain inflammatory homeostasis and to induce immune ...
Platzer B B Division of Gastroenterology and Nutrition, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, - - 2014
Antigen-mediated cross-linking of Immunoglobulin E (IgE) bound to mast cells/basophils via FcɛRI, the high affinity IgE Fc-receptor, is a well-known trigger of allergy. In humans, but not mice, dendritic cells (DCs) also express FcɛRI that is constitutively occupied with IgE. In contrast to mast cells/basophils, the consequences of IgE/FcɛRI signals ...
Fulkerson Patricia C PC Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH - - 2014
Eosinophils originate in the bone marrow from an eosinophil lineage-committed, IL-5Rα-positive, hematopoietic progenitor (eosinophil progenitor). Indeed, IL-5 is recognized as a critical regulator of eosinophilia and has effects on eosinophil progenitors, eosinophil precursors, and mature eosinophils. However, substantial levels of eosinophils remain after IL-5 neutralization or genetic deletion, suggesting that ...
Zasłona Zbigniew Z Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI - - 2014
The role and origin of alveolar macrophages (AMs) in asthma are incompletely defined. We sought to clarify these issues in the context of acute allergic lung inflammation using house dust mite and OVA murine models. Use of liposomal clodronate to deplete resident AMs (rAMs) resulted in increased levels of inflammatory ...
Kumar Rakesh K RK Department of Pathology, School of Medical Sciences, UNSW Australia, Sydney, - - 2014
Exposure to airborne particulate matter (PM) may promote development of childhood asthma and trigger acute exacerbations of existing asthma via injury to airway epithelial cells (AEC). We compared the response of AEC to ambient particulates with median aerodynamic diameters of <10 μm or <2.5 μm from the Sydney metropolitan region (Sydney PM10 ...
Raedler Diana D University Children's Hospital Munich, Department of Pulmonary & Allergy, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, - - 2014
Childhood asthma is classified into allergic asthma (AA) and nonallergic asthma (NA), yet both are treated identically, with only partial success. We sought to identify novel immune phenotypes for childhood AA and NA. The Clinical Asthma Research Association cohort study includes 275 steroid-naive 4- to 15-year-old German children (healthy control ...
Schaumann Frank - - 2014
BackgroundEpidemiological and experimental studies suggest that exposure to ultrafine particles (UFP) might aggravate the allergic inflammation of the lung in asthmatics.MethodsWe exposed 12 allergic asthmatics in two subgroups in a double-blinded randomized cross-over design, first to freshly generated ultrafine carbon particles (64 ¿g/m3; 6.1¿±¿0.4 × 105 particles/cm3 for 2 h) and then ...
Nabe Takeshi T Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, - - 2014
Interleukin (IL)-33, a member of the IL-1 family of cytokines, is produced when epithelial and endothelial cells are exposed to stimuli. Hematopoietic cells such as macrophages also produce IL-33. IL-33 is considered to function as an 'alarmin', activating various immune cells through its receptor ST2, which leads to the production ...
Miraglia Del Giudice Michele M Department of Pediatrics, Second University of Naples, Naples, - - 2014
Social and economic costs of allergic rhinitis (AR) are impressive; AR may also significantly impact school attendance and performance, quality of life, and sleep (1). The AR immunopathology is characterized by T-helper-2 (Th2)-dependent inflammation and Th1-response impairment. This imbalance is sustained by dysfunction of immune system: allergic patients are lacking ...
Eom Sangkyung S Kangwon National University, Korea, Republic - - 2014
The molecular mechanism of transglutaminase II (TGaseII)-mediated allergic inflammation remains largely unknown. TGaseII, induced by antigen stimulation, showed an interaction and co-localization with FcεRI. TGaseII was necessary for in vivo allergic inflammation, such as triphasic cutaneous reaction (TpCR), passive cutaneous anaphylaxis (PCA), and passive systemic anaphylaxis (PSA). TGaseII was necessary ...
McGovern Toby K TK McGill University, Medicine, Montreal, Quebec, Canada ; - - 2014
ABSTRACT Rationale: Chlorine gas (Cl2) inhalation causes oxidative stress, airway epithelial damage, airway hyperresponsiveness (AHR) and neutrophilia. Objectives: We evaluated the effect of neutrophil depletion on Cl2-induced AHR, affect the endogenous anti-oxidant response and, if eosinophils or macrophages influence Cl2-induced AHR. Methods: We exposed male Balb/C to 100ppm Cl2 for ...
Guzmán Mauricio M Immunology, Institute of Experimental Medicine, National Academy of Medicine/CONICET, Pacheco de Melo 3081, Buenos Aires, C1425AUM, - - 2014
Purpose: To evaluate the role of nuclear factor kappa B (NF-κB) activation in eye drop preservative toxicity and the effect of topical NF-κB inhibitors on preservative-facilitated allergic conjunctivitis. Methods: Balb/c mice were instilled ovalbumin (OVA) combined with benzalkonium chloride (BAK) and/or NF-κB inhibitors in both eyes. After immunization, T cell ...
Sumpter Tina L TL Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, - - 2014
Efficient development of atopic diseases requires interactions between allergen and adjuvant to initiate and amplify the underlying inflammatory responses. Substance P (SP) and hemokinin-1 (HK-1) are neuropeptides that signal through the neurokinin-1 receptor (NK1R) to promote inflammation. Mast cells initiate the symptoms and tissue effects of atopic disorders, secreting TNF ...
Tian Bao-Ping BP Zhejiang University School of Medicine, Respiratory and Critical Care Medicine, Hangzhou, China ; - - 2014
Interleukin-17A (IL-17) is known to play important roles in immune and inflammatory disease such as in asthma, but its functions in allergic airway inflammation are still controversial, and the molecular mechanisms mediating these functions remain unclear. Increased production of eosinophils in bone marrow and their emergence in the airway have ...
Lambrecht Bart N BN Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium; Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium; Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands. Electronic address: - - 2014
Allergic sensitization to inhaled antigens is common but poorly understood. Although lung epithelial cells were initially merely regarded as a passive barrier impeding allergen penetrance, we now realize that they recognize allergens through expression of pattern recognition receptors and mount an innate immune response driven by activation of nuclear factor ...
Chesné J J INSERM UMR 1087, Institut du thorax, Nantes, Loire Atlantique, France, CNRS 6291, Nantes, Loire Atlantique, France, Université de Nantes, Nantes, Loire Atlantique, France ; - - 2014
Asthma is a major chronic disease ranging from mild to severe refractory disease and is classified into various clinical phenotypes. Severe asthma is difficult to treat and frequently requires high doses of systemic steroids. In some cases, severe asthma even responds poorly to steroids. Several studies have suggested a central ...
Hou Changchun - - 2014
The pro-inflammation factor high-mobility group box protein 1 (HMGB1) has been implicated in the pathogenesis of asthma. In this study, we used a murine model of chronic asthma to evaluate the effects of HMGB1 on airway remodeling. Female BALB/c mice were randomly divided into four groups: control, ovalbumin (OVA) asthmatic, ...
Murdoch Jenna R JR Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, UK, SW7 - - 2014
γδT cells play a crucial immunoregulatory role in the lung, maintaining normal airway tone and preventing hyperresponsiveness to innocuous allergen. During acute inflammatory episodes, γδT cells promote resolution of acute inflammation. However their contribution to inflammation associated airway remodelling remains unexplored. Here we investigate the effects of γδT cell blockade ...
Shin In-Sik IS Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea; College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of - - 2014
Asthma is a common chronic inflammatory airway disease that is recognized as a major public health problem. In this study, we evaluated the effects of melatonin on allergic asthma using a murine model of ovalbumin (OVA)-induced allergic asthma and BEAS-2B cells. To induce allergic asthma, the mice were sensitized and ...
Woo Yeonduk Y Laboratory of Immune Regulation, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-744, - - 2014
Asthma is a common pulmonary disease with several different forms. The most studied form of asthma is the allergic form, which is mainly related to the function of Th2 cells and their production of cytokines (IL-4, IL-5, and IL-13) in association with allergen sensitization and adaptive immunity. Recently, there have ...
Lee Hyun Jae HJ Department of Pharmacology, Chungnam National University School of Medicine, Daejeon, - - 2014
It is valuable to find the potential activity of regulating the excessive mucin secretion by the compounds derived from various medicinal plants. We investigated whether aqueous extract of the root bark of Morus alba L. (AMA), kuwanon E, kuwanon G, mulberrofuran G, and morusin significantly affect the secretion and production ...
Cuppari Caterina C Department of Pediatrics, Unit of Pediatric Genetics & Immunology, University of Messina, - - 2014
Allergen immunotherapy is a disease-modifying therapy, effective for the treatment of allergic rhinitis, allergic asthma, conjunctivitis or stinging insect allergy. Allergen immunotherapy involves the administration of increasing doses of allergens with the aim of ameliorating the allergic response. Although precise underlying mechanisms of the induction of immune tolerance remain unclear, ...
Athari Seyyed Shamsadin SS Department of Immunology, Faculty of Medical Science, Tarbiat Modares University, Tehran, - - 2014
HBV is a non-cytopathic virus and cell mediated immune response against this. Humoral mediated immune response are responsible for allergic diseases. Balance between these two subsets of Th CD4+ cells are result of the immune system response. A 56 year old woman presented with chronic HBV infection, allergic asthma, type ...
Popescu Florin-Dan FD Florin-Dan Popescu, Department of Allergology, "Carol Davila" University of Medicine and Pharmacy, "Nicolae Malaxa" Clinical Hospital, Department of Allergology and Clinical Immunology, 022441 Bucharest, - - 2014
Grass pollen allergy represents a significant cause of allergic morbidity worldwide. Component-resolved diagnosis biomarkers are increasingly used in allergy practice in order to evaluate the sensitization to grass pollen allergens, allowing the clinician to confirm genuine sensitization to the corresponding allergen plant sources and supporting an accurate prescription of allergy ...
Moreira Flavio Tocci FT Department of Medicine, Federal University of São Paulo, Sao Paulo, SP, - - 2014
To compare the effects of two of the most effective lipid-lowering therapies with similar LDL-cholesterol reduction capacity on the innate and adaptive immune responses through the evaluation of autoantibodies anti- oxidized LDL (anti-oxLDL Abs) and electronegative LDL [LDL(-)] levels. We performed a prospective, randomized, open label study, with parallel arms ...
Sahoo Anupama A Department of Immunology, M. D. Anderson Cancer Center, Houston, Texas 77030, - - 2014
T helper (Th)-2 cells are the major players in allergic asthma; however, the mechanisms that control Th2-mediated inflammation are poorly understood. Here we find that enhanced expression of Grail, an E3 ubiquitin ligase, in Th2 cells depends on interleukin (IL)-4-signalling components, signal transducer and activator of transcription 6 (Stat6) and ...
Knol Edward F EF Department Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands, - - 2014
Despite growing use of flow cytometry to analyze the functional characteristics of primary basophils the intracellular signaling cascades that control their ability to elaborate various inflammatory mediators and cytokines remain comparatively obscure. Additionally, some studies require the analysis of pro-allergic and inflammatory mediators, such as histamine, LTC4, and various basophil-derived ...
Verheijden Kim A T KA Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University Utrecht, - - 2014
In this study a direct comparison was made between non-invasive and non-ventilated unrestrained whole body plethysmography (Penh) (conscious animals) and the invasive ventilated lung resistance (RL) method (anesthetized animals) in both mild and severe allergic airway inflammation models. Mild inflammation was induced by intraperitoneal sensitization and aerosols of ovalbumin. Severe ...
Liu Wenlong W Department of Otolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, No. 9 Jinsui Road, Guangzhou 510623, - - 2014
Background. Interleukin-37 (IL-37), a newly described member of IL-1family, functioned as a fundamental inhibitor of innate inflammatory and immune responses, especially its isoform IL-37b. Objective. This study was undertaken to evaluate the expression and regulation of IL-37b in children with allergic rhinitis (AR). Methods. Forty children with AR and twenty-five ...
Zhu Linnan L 1] State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China - - 2014
Macrophages acquire distinct phenotypes during tissue stress and inflammatory responses, but the mechanisms that regulate the macrophage polarization are poorly defined. Here we show that tuberous sclerosis complex 1 (TSC1) is a critical regulator of M1 and M2 phenotypes of macrophages. Mice with myeloid-specific deletion of TSC1 exhibit enhanced M1 ...
Drake Li Yin LY Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA; Department of Immunology, Mayo Clinic, Rochester, Minnesota, - - 2014
As the first line of defense, innate immunity plays an important role in protecting the host against pathogens. Innate lymphoid cells (ILCs) are emerging as important effector cells in the innate immune system and the cell type that regulate immune and tissue homeostases. Group 2 ILCs (ILC2s) are a subset ...
Shen Dandan D National Standard Laboratory of Pharmacology for Chinese Materia Medica, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China; Pharmacy Department, The First People's Hospital of Taicang, Taicang, - - 2014
Yu-ping-feng-san (YPFS) is a Chinese medical formula that is used clinically for allergic diseases and characterized by reducing allergy relapse. Our previous studies demonstrated that YPFS efficiently inhibited T helper 2 cytokines in allergic inflammation. The underlying mechanisms of action of YPFS and its effective components remain unclear. In this ...
Pritchard Antonia L AL Lung and Allergy Research Group, School of Medicine, The University of Queensland, Translational Research Institute (TRI), Woolloongabba, Brisbane, - - 2014
Human rhinovirus (HRV) infection is a major trigger for asthma exacerbations. Anti-viral immunity appears to be abnormal in asthma, with immune dysfunction reported in both airway structural cells and migratory, bone marrow derived cells. Though decreased capacity to produce anti-viral interferons (IFNs) has been reported in asthma, a detailed analysis ...
Tsujimura Yusuke Y Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Tsukuba, Ibaraki, - - 2014
Many epidemiological studies have suggested that the recent increase in prevalence and severity of allergic diseases such as asthma is inversely correlated with Mycobacterium bovis bacillus Calmette Guerin (BCG) vaccination. However, the underlying mechanisms by which mycobacterial components suppress allergic diseases are not yet fully understood. Here we showed the ...
Kim Sae-Hoon SH Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of - - 2014
Epidemiologic clinical studies suggested that chronic exposure to chlorine products is associated with development of asthma and aggravation of asthmatic symptoms. However, its underlying mechanism was not clearly understood. Studies were undertaken to define the effects and mechanisms of chronic low-dose chlorine exposure in the pathogenesis of airway inflammation and ...
Vatrella Alessandro A Department of Medicine and Surgery, University of Salerno, Salerno, - - 2014
Simultaneously with the steady progress towards a better knowledge of the pathobiology of asthma, the potential usefulness of anticytokine therapies is emerging as one of the key concepts in the newly developing treatments of this widespread airway disease. In particular, given the key role played by interleukin (IL)-4 and IL-13 ...
Hanssen Sveinn Are SA Norwegian Institute for Nature Research, Unit for Arctic Ecology, Fram Centre N-9296, Tromsø, - - 2013
Parasites are natural stressors that may have multiple negative effects on their host as they usurp energy and nutrients and may lead to costly immune responses that may cause oxidative stress. At early stages, animals may be more sensitive to infectious organisms because of their rapid growth and partly immature ...
McNamara K B - - 2013
Despite the ubiquitous nature of sperm storage in invertebrates, relatively little is known about its costs, or the impact that immune activation can have on a female's ability to maintain viable sperm stores. We explored the effects of an immune challenge on sperm storage under food-limited and ad libitum conditions ...
Humphries Ashley C - - 2013
The role of clathrin in pathogen entry has received much attention and has highlighted the adaptability of clathrin during internalization. Recent studies have now uncovered additional roles for clathrin and have put the spotlight on its role in pathogen spread. Here, we discuss the manipulation of clathrin by pathogens, with ...
Karanika Styliani S Colorectal Unit, First Department of Propaedeutic Surgery, Athens Medical School, Athens, - - 2013
Colorectal cancer (CRC) is the third leading cause of cancer mortality worldwide and laparoscopic colectomy has been established as equivalent to the open approach in terms of oncological results and patients' safety. Survival benefits have been reported in favor of laparoscopic colectomy (LC) in stage III CRC patients. Different immune ...
Zhao Feng - - 2012
The aim of this study was to investigate the effect and the potential molecular mechanism of sustained inflation (SI) recruitment maneuvers in acute respiratory distress syndrome (ARDS) in beagle dog following endotracheal suctioning. ARDS was induced in 24 beagle dogs with oleic acid. They had mechanical ventilation support. They were ...
Jones L A - - 2012
The degree of periparturient relaxation of immunity to gastrointestinal parasites has a nutritional basis, as overcoming protein scarcity through increased protein supply improves lactational performance, enhances local immune responses and reduces worm burdens. Herein lactating rats, re-infected with Nippostrongylus brasiliensis, are used to test the hypothesis that a similar and ...
Zamilpa Rogelio R San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, - - 2012
Following myocardial infarction (MI), activated macrophages infiltrate into the necrotic myocardium as part of a robust pro-inflammatory response and secrete matrix metalloproteinase-9 (MMP-9). Macrophage activation, in turn, modulates the fibrotic response, in part by stimulating fibroblast extracellular matrix (ECM) synthesis. We hypothesized that overexpression of human MMP-9 in mouse macrophages ...
Namkung Jeong - - 2012
Context:Müllerian inhibiting substance (MIS) is produced in Sertoli cells of fetal testis and causes regression of Müllerian ducts in male embryos. MIS also can induce the cell cycle arrest and apoptosis in Müllerian duct-derived tumors in vivo and in vitro.Objective:Our objective was to investigate the expression of MIS type II ...
Ghourbani Gazar Samira - - 2012
Background: Atherosclerosis is a multifactorial disorder with chronic inflammatory conditions in which immune cells play a significant role in its pathogenic process. Regulatory T cells (Treg), as a part of immune system, are involved in controlling auto-immune and inflammatory diseases. Tregs have been shown to play an atheroprotective role and ...
Yao Ling-Ling - - 2012
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is known to be a "housekeeping" protein, studies in non-cardiomyocytic cells have shown that GAPDH plays pro-apoptotic role by translocating from cytoplasm to the nucleus or to the mitochondria. However, the cardiovascular roles of GAPDH are unknown. We observed that phenylephrine (PE) (100 µM) protected against serum and ...
Thorp Edward B - - 2012
In cardiovascular disorders including advanced atherosclerosis and myocardial infarction (MI), increased cell death and tissue destabilization is associated with recruitment of inflammatory monocyte subsets that give rise to differentiated macrophages. These phagocytic cells clear necrotic and apoptotic bodies and promote inflammation resolution and tissue remodeling. The capacity of macrophages for ...
Chinetti-Gbaguidi Giulia - - 2012
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the intracellular reduction of inactive cortisone to active cortisol, the natural ligand activating the glucocorticoid receptor (GR). Peroxisome proliferator- activated receptor-γ (PPARγ) is a nuclear receptor controlling inflammation, lipid metabolism, and the macrophage polarization state. In this study, we investigated the impact of macrophage ...
Moon Jung Lee - - 2011
Brefeldin A (BFA), an endoplasmic reticulum (ER)-Golgi transport inhibitor, has been shown to cause accumulation of proteins in the ER, ER stress, and ultimately apoptosis. In this paper, we demonstrate that the knockdown of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm), a mitochondrial NADPH-generating enzyme, by small interfering RNA (siRNA) enhanced BFA-induced ...
1 2 3 4 5 6 7 8 9 10 >