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Montano-Loza Aldo J AJ Division of Gastroenterology and Liver Unit, University of Alberta Hospital, Edmonton, AB, - - 2014
Autoimmune hepatitis is associated with interactive cell populations of the innate and adaptive immune systems, and these populations are amenable to therapeutic manipulation. The goals of this review are to describe the key cell populations implicated in autoimmune hepatitis and to identify investigational opportunities to develop cell-directed therapies for this ...
Chatterjee Nabanita N Cancer Biology & Inflammatory Disorder Division, CSIR - Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata, West Bengal 700032, - - 2014
Persistence of liver injury alters the internal milieu, promotes deregulation of inflammatory factors, and leads to dysplastic lesions like fibrosis, cirrhosis to hepatocellular carcinoma. Our previous study revealed that leishmanial lipid (pLLD) exerts potential anti-inflammatory activity in sepsis associated hepatic injury. We now show that pLLD gives protection against chemical ...
Mao Qiang Q Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, - - 2014
Clonorchiasis, caused by direct and continuous contact with Clonorchis sinensis, is associated with hepatobiliary damage, inflammation, periductal fibrosis, and the development of cholangiocarcinoma. Hepatic stellate cells respond to liver injury through production of proinflammatory mediators which drive fibrogenesis; however, their endogenous sources and pathophysiological roles in host cells were not ...
Zou Chengcheng C Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, - - 2014
The hepatitis B virus (HBV) is responsible for most of hepatocellular carcinoma (HCC). However, whether HBV plays an important role during hepatocarcinogenesis through effecting miRNAs remains unknown. Here, we reported that HBV up-regulated microRNA-181a (miR-181a) by enhancing its promoter activity. Simultaneously, we found that miR-181a inhibited apoptosis in vitro and ...
Yao Ning N Clinic College of Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, P.R. - - 2014
Oxymatrine, extracted from the herb Sophora alopecuraides L., was investigated to determine its anti-HBV immunomodulatory mechanism in vitro. Human peripheral lymphocytes were isolated from heparinized whole blood from 48 chronic hepatitis B (CHB) patients. The lymphocytes from each patient were divided into two groups according to pretreatment or no pretreatment ...
Maeda Hitoshi H Kumamoto - - 2014
Since reactive oxygen species (ROS) derived from Kupffer cells (KC), especially CD68+ KC, play a key role in the induction of hepatic oxidative stress and injuries, we newly developed a polythiolated- and mannosylated-human serum albumin (SH-Man-HSA), a novel nano-antioxidant for delivering thiol to CD68+ KC. In vitro electron paramagnetic resonance ...
Chtourou Yassine Y Toxicology- Microbiology and Environnemental Health Unit (UR11ES70), Faculty of Sciences, University of Sfax, Tunisia. Electronic address: - - 2014
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of hepatic abnormalities that extends from isolated steatosis to non-alcoholic steatohepatitis (NASH) and steatofibrosis. NASH is the progressive form of the disease that can lead to fibrosis, cirrhosis and hepatocellular carcinoma. Naringenin (NGEN), a healthful food, increases resistance to oxidative stress, inflammation ...
Shimada Shingo S Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, - - 2014
Hydrogen sulfide (H2S) ameliorates hepatic ischemia and reperfusion injury (IRI), but the precise mechanism remains elusive. We investigated whether sodium hydrogen sulfide (NaHS), a soluble derivative of H2S, would ameliorate hepatic IRI, and if so, via what mechanism. Mice were subjected to partial warm ischemia for 75 min followed by reperfusion. ...
Defamie V V Ontario Cancer Institute, University of Toronto, Toronto, Ontario, - - 2014
Inflammation enables human cancers and is a critical promoter of hepatocellular carcinoma (HCC). TIMP3 (Tissue inhibitor of metalloproteinase 3), a natural metalloproteinase inhibitor, controls cytokine and growth factor bioavailability to keep inflammation in check and regulate cell survival in the liver. TIMP3 is also found silenced in human cancers. We ...
Yao Jun J Jun Yao, Chun-Suo Zhou, Bai-Qing Fu, Li-Sheng Tao, Ya-Ping Xu, Department of Gastroenterology, the People's Hospital Affiliated to Jiangsu University, Zhenjiang 212002, Jiangsu Province, - - 2014
To examine the effect of farnesoid X receptor (FXR) activation by GW4064 on endotoxin-induced hepatic inflammation in nonalcoholic fatty liver disease (NAFLD) and the underlying mechanism. Six-week-old male C57BL/6 mice were fed a normal diet or a high-fat (HF) diet for 8 wk. HF diet-fed mice were intraperitoneally injected with ...
Hammerich Linda L Dept. of Medicine III, RWTH University-Hospital Aachen, Pauwelsstrasse 30, 52074, Aachen, - - 2014
Molecular factors driving immune-mediated inflammation in the liver are incompletely understood. The transcription factor cyclic AMP responsive element modulator-alpha (CREMα) can endorse differentiation of T lymphocytes towards Th17 cells, thereby promoting autoimmunity in systemic lupus erythematosus or lung inflammation. To investigate the role of CREMα in liver disease we subjected ...
Hou Xin X Department of Microbiology and Parasitology, Anhui Provincial Laboratory of Microbiology and Parasitology, Anhui Medical University, PR China. Electronic address: - - 2014
Foxp3(+) Tregs play important roles in maintaining homeostasis by suppressing excessive immune responses that result in serious tissue damage; yet, it is largely unknown about the impact of Tregs on innate immune cells in hepatitis models in vivo. In this study, we examined the effect of hepatic Tregs on innate ...
Zhang Mengran M Institutes of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, 8 East Jingshun St., Beijing, 100015, China, - - 2014
Activation of hepatic stellate cell (HSC) is the central event in liver fibrosis. NS5ATP9 is related to many malignant tumors, but little is known about its function in HSC activation. The aim of this study is to investigate the role of NS5ATP9 in HSC activation in vitro. Genes related to ...
Navarro Laura A LA Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, - - 2014
Innate immune activation has been postulated as a central mechanism for disease progression from hepatic steatosis to steatohepatitis in obesity-related fatty liver disease. Arginase 2 competes with inducible nitric oxide synthase (iNOS) for its substrate and the balance between these two enzymes plays a crucial role in regulating immune responses ...
Fabre Thomas T Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec H3C 3J7, - - 2014
Activation of hepatic stellate cells (HSCs) is a key event in the initiation of liver fibrosis, characterized by enhanced extracellular matrix production and altered degradation. Activation of HSCs can be modulated by cytokines produced by immune cells. Recent reports have implicated the proinflammatory cytokine IL-17A in liver fibrosis progression. We ...
Chen Gang G 333 BuKui Street, JianHua District, Qiqihar, The Institute of Medicine, Qiqihar Medical University, Qiqihar, 161006, - - 2014
The major feature in the molecular pathogenesis of hepatic fibrosis requires maintenance of the activated hepatic stellate cells (HSCs) phenotype by both proliferation and inhibition of apoptosis. Thus, the induction of activated HSCs apoptosis has been proposed as an antifibrotic treatment strategy. Curcumol has pro-apoptotic activity in a number of ...
Zhang Xiao-Dong XD 1 Department of Cancer Research, 2 Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, - - 2014
The chronic infection of hepatitis B virus (HBV) is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV X protein (HBx protein) is a multifunctional regulator with a crucial role in hepatocarcinogenesis. However, information on the mechanism by which HBV induces HCC ...
Saiman Yedidya Y Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, - - 2014
Activation of hepatic stellate cells and development of chronic inflammation are two key features in the progression of hepatic fibrosis. We have shown that in vitro activated stellate cells increase their expression of CXCL12 as well as the receptor CXCR4 and that receptor engagement promotes a profibrogenic phenotype. Furthermore, injury ...
He Fei F Department of Hepatic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, - - 2014
Macrophages play multi-dimensional roles in hepatic fibrosis, but their control has not been fully understood. Literatures have shown that the Notch pathway mediated by RBP-J, the transcription factor transactivated by signals from four mammalian Notch receptors, is implicated in macrophage activation and plasticity. In this study, by using mouse hepatic ...
Sherwood Joanna J Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, - - 2014
ELR+ CXC chemokines are heparin-binding cytokines signalling through the CXCR1 and CXCR2 receptors. ELR+ CXC chemokines have been associated with inflammatory arthritis due to their capacity to attract inflammatory cells. Here, we describe an unsuspected physiological function of these molecules in articular cartilage homeostasis. Chemokine receptors and ligands were detected ...
Niemietz Thomas T Research Center for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany, - - 2014
Xenogeneic or allogeneic chondrocytes hold great potential to build up new cartilage in vivo. However, immune rejection is a major concern for the utility of universal donor-derived cells. In order to verify the reported immune privilege of chondrocytes in vivo, the aim of this study was to assess engraftment of ...
Liu Qin Q The Medical and Scientific Research Center, Guangxi Medical University, Nanning, 530021, China; Research Center for Regenerative Medicine, Guangxi Medical University, Nanning, 530021, - - 2014
The ideal therapeutic agent for treatment of osteoarthritis (OA) should have not only potent anti-inflammatory effect but also favorable biological properties to restore cartilage function. Gallic acid (GA) and its derivatives are anti-inflammatory agents reported to have an effect on OA [1]. However, GA has much weaker antioxidant effects and ...
Kato Tomohiro - - 2014
Osteoarthritis (OA) is a whole joint disease, and characterized by progressive degradation of articular cartilage, synovial hyperplasia, bone remodeling and angiogenesis in various joint tissues. Exosomes are a type of microvesicles (MVs) that may play a role in tissue-tissue and cell-cell communication in homeostasis and diseases. We hypothesized that exosomes ...
Wang Jianxin J Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China; Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People's Republic of - - 2014
The induction of hepatic stellate cell (HSC) apoptosis has potential as a potent strategy to diminish the progression of liver fibrosis. Previous studies have demonstrated the ability of soluble egg antigens (SEA) from schistosomes to inhibit HSC activation and to induce apoptosis in vitro. In this study, we aimed to ...
Yu Seon-Mi SM 0000-0002-3556-2199 Department of Biological Sciences, Kongju National University, Gongju, - - 2014
Withaferin A (WFA) is known as a constituent of Ayurvedic medicinal plant, Withania somnifera, and has been used for thousands of years. Although WFA has been used for the treatment of osteoarthritis (OA) and has a wide range of biochemical and pharmacologic activities, there are no findings suggesting its properties ...
Willard Vincent P VP Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC, - - 2014
Objective: The discovery of novel disease-modifying drugs for osteoarthritis (OA) is limited by the lack of adequate genetically-defined cartilage tissues for application in high-throughput screening systems. We addressed this need by synthesizing cartilage from induced pluripotent stem cells (iPSCs) to establish and validate an in vitro model of OA. Methods: ...
Hughes Chris - - 2014
We have previously demonstrated that a single chain fragment variable (scFv) specific to collagen type II (CII) post-translationally modified by reactive oxygen species (ROS) can be used to target anti-inflammatory therapeutics specifically to inflamed arthritic joints. The objective of the present study was to demonstrate the superior efficacy of anti-inflammatory ...
Hwang Hye Seong HS Biotherapeutics and Glycomics Laboratory, College of Pharmacy, Chung-Ang University, 221 Huksuk-dong, Dongjak-ku, Seoul 156-756, South - - 2014
Ovalbumin (OA) is one of the most abundant of the glycoprotein allergens, and induces a T-helper type 2 (Th2) immune response that results in an IgE-mediated hypersensitivity. In this study, the terminal carbohydrates of N-glycans from intact OA were cleaved with the exoglycosidases galactosidase, mannosidase, and N-acetylglucosaminidase to generate degalactosylated-OA, ...
Lee Jeongmin J Research Institute of Clinical Nutrition, Kyung Hee University, Seoul 130-701, Korea. ; Department of Medical Nutrition, Kyung Hee University, Gyeonggi 446-701, - - 2014
We investigated the effect of Pycnogenol (Pyc) on survival and immune dysfunction of C57BL/6 mice induced by low micronutrient supplementation. Female C57/BL/6 mice were fed a diet containing 7.5% of the recommended amount of micronutrients for a period of 12 wks (immunological assay) and 18 wks (survival test). For immunological ...
Sun Tao T Department of Orthopedics, Yantaishan Hospital, Yantai 264025, Shangdong Province, - - 2014
Osteoarthritis (OA), one of the most common joint disorders, is one of the leading causes of disability among the elderly. Proinflammatory cytokines, such as interleukin (IL)-1β, which is synthesized locally by synovial cells and chondrocytes, have been shown to play a critical role in sustaining cartilage damage in arthritis by ...
Zhang Ying Y 1 Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University , Morgantown, West - - 2014
Cartilage defects are normally concomitant with posttraumatic inflammation and pose a major challenge in cartilage repair. Due to the avascular nature of cartilage and its inability to surmount an inflammatory response, the cartilage is easily attacked by proinflammatory factors and oxidative stress; if left untreated, osteoarthritis may develop. Suppression of ...
Fahy Niamh N National University of Ireland Galway, Regenerative Medicine Institute, Galway, Ireland ; - - 2014
Osteoarthritis (OA), the most common form of arthritis, is a disabling degenerative joint disease affecting synovial joints and is associated with cartilage destruction, inflammation of the synovial membrane and subchondral bone remodelling. Inflammation of the synovial membrane may arise secondary to degenerative processes in articular cartilage, or may be a ...
Shibuya Nobuhito N Department of Plastic and Reconstructive Surgery, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai-shi, Miyagi 980-8575, Japan. E-mail address for N. Shibuya: - - 2014
Osteochondral allograft transplantation is used to treat severe cartilage injury or chondral defects, with good outcomes in clinical studies. However, allograft chondrocyte death due to apoptosis may occur during storage or as a result of implantation stress. We investigated a third possible cause, chondrocyte apoptosis resulting from an immune response, ...
Sherwood Joanna C JC Barts and The London, Queen Mary University of London School of Medicine and Dentistry, William Harvey Research Institute, London, - - 2014
Cartilage breakdown is the disabling outcome of rheumatic diseases, whether prevalently inflammatory such as rheumatoid arthritis or prevalently mechanical such as osteoarthritis (OA). Despite the differences between immune-mediated arthritides and OA, common mechanisms drive cartilage breakdown. Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research and ...
Zhang Xiaodong X Medical Center of Hip, Luoyang Orthopedic-Traumatological Hospital, Henan, PR - - 2014
Osteoarthritis (OA), characterized by progressive destruction of articular cartilage, is the most common form of human arthritis and a major concern for aging societies worldwide. In OA, pro-inflammatory cytokines such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α can trigger the caspase cascade to promote apoptosis and activate NF-κB to ...
Liu Xiao X The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, University of Melbourne, Parkville, - - 2014
Objective. This study examines the impact of the gp130 cytokine family on cartilage and a potential regulatory role for Suppressor of Cytokine Signaling-3 (SOCS3) in chondrocytes. Methods. Baseline receptor expression levels and gp130 cytokine-induced JAK-STAT signaling were determined by flow cytometry in wild-type (WT) chondrocytes and SOCS3 expression in chondrocytes ...
Uehara Yusuke Y Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. Electronic address: - - 2014
When endoplasmic reticulum (ER) stress, i.e. the excessive accumulation of unfolded proteins in ER, endangers homeostasis, apoptosis is induced by C/EBP homologous protein (Chop). In osteoarthritis (OA) cartilage, Chop expression and apoptosis increase as degeneration progresses. We investigated the role of Chop in murine chondrocyte apoptosis and in the progression ...
Ponnunrangam Sathish S Columbia University, Dept. Earth and Environmental Engineering, Columbia University, 918 S. W. Mudd Hall, 500 West 120th Street, Mail Code: 4711, New York, New York, United States, 10027, 2128542925, 2128547081 ; - - 2014
The harsh inflammatory environment associated with injured and arthritic joints represents a major challenge to articular cartilage repair. In this study, we report the effect of cerium oxide nanoparticles, or nanoceria, in modulating development of engineered cartilage and in combating the deleterious effects of interleukin-1α. Nanoceria were found to be ...
Glass Katherine A KA Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27708, - - 2014
The pathogenesis of osteoarthritis is mediated in part by inflammatory cytokines including interleukin-1 (IL-1), which promote degradation of articular cartilage and prevent human mesenchymal stem cell (MSC) chondrogenesis. In this study, we combined gene therapy and functional tissue engineering to develop engineered cartilage with immunomodulatory properties that allow chondrogenesis in ...
Kwon Heenam H Program in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, 136 Harrison Avenue, Boston, MA, 02111, - - 2014
Cartilage tissue engineering has emerged as an attractive therapeutic option for repairing damaged cartilage tissue in the arthritic joint. High levels of pro-inflammatory cytokines present at arthritic joints can cause cartilage destruction and instability of the engineered cartilage tissue, and thus it is critical to engineer strong and stable cartilage ...
Longhuo Wu - - 2014
Osteoarthritis (OA) is a chronic degenerative disease leading to aberrance of cartilage structures with unclear or multifactorial mechanisms. Recently, a great portion of research endeavor to explore the molecular mechanisms of OA has been focused on the mitochondrial pathology. Mitochondrial respiratory chain (MRC) produces reactive oxygen species (ROS), which in ...
Liu Ning N Department of Orthopaedic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. - - 2014
For the past 60 years, glucocorticosteroid (GC) drugs, including prednisone and dexamethasone (Dex), have been used for the treatment of early stage osteoarthritis (OA). However, multiple administration of GCs may destroy the articular cartilage. It has been previously reported that GC treatment may also lead to the initiation of autophagy, which ...
Zhang Xiaohong X School of Biomedical Science, Huaqiao University, Quanzhou, - - 2014
Preclinical Research Osteoarthritis (OA) is characterized by a loss of articular cartilage accompanied with inflammation of synovium. β-Ecdysterone (Ecd), a major component of several Chinese herbal medicines, e.g., Achyranthes bidentata BL., has been used for the prevention and treatment of OA. Ecd is an estrogen analog and is likely to have ...
Alvarez-Garcia Oscar O Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, - - 2014
Objectives Obesity is a major risk factor for the development of osteoarthritis (OA) that is associated with a state of low-grade inflammation, and increased circulating adipokines and free fatty acids (FFA). The aim of this study was to analyze effects of saturated (palmitate) and monounsaturated (oleate) free fatty acids (FFA) ...
Xiong Chengjie C Orthopedic Department, Wuhan General Hospital of Guangzhou Military Area Command, Wuhan, - - 2014
Type 1 Modic changes are characterized by edema, vascularization, and inflammation, which lead to intervertebral disc degeneration. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine closely related to the inflammatory cytokines detected in degenerative intervertebral disc tissues. However, the existence and role of MIF and its receptor CD74 in ...
Lu Huading H Department of Orthopaedics, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. - - 2014
Osteoarthritis (OA) is a chronic degenerative joint disorder in which genetic, hormonal, mechanical and ageing factors affect its progression. Current studies are focusing on chondrocytes as a key mediator of OA at a cellular level. however, the mechanism underlying chondrocyte apoptosis remains unclear. PUMA is a pro-apoptotic member of the BH3-only subgroup ...
Balaganur Venkanna V Division of Pharmacology & Toxicology, Indian Veterinary Research Institute, Bareilly, UP, - - 2014
To study the chondroprotective and anti-inflammatory potential of inducible nitric oxide synthase (iNOS) inhibitor S-methylisothiourea (SMT) in in-vitro model. Rabbit cartilage explants were stimulated with recombinant human interleukin 1β (rhIL-1β), and the chondroprotective and anti-inflammatory effects of SMT were investigated. Rat synovial explants were stimulated with LPS, and the anti-inflammatory ...
Siebelt M M Department of Orthopedics, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: - - 2014
Osteoarthritis (OA) is a non-inflammatory joint disease characterized by progressive degeneration of the cartilage extra-cellular matrix (ECM), enhanced subchondral bone remodelling, activation of synovial macrophages and osteophyte growth. Inhibition of calcineurin activity through tacrolimus (FK506) in in vitro monolayer chondrocytes exerts positive effects on ECM marker expression. This study therefore ...
Barbosa Carmem Patrícia CP Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, - - 2014
The objective of the present study was to investigate the effects of monotherapy with simvastatin or ezetimibe compared with those of an ezetimibe + simvastatin combination on the histopathologic aspects of arthritis induced by Complete Freund's Adjuvant in rats. The characteristics of diarthrosis were analyzed 7 and 28 days after arthritis ...
Henrotin Yves Y Bone and Cartilage Research Unit, Institute of Pathology, CHU Sart-Tilman, University of Liège, 4000 Liège, - - 2014
Synovitis is a key feature in osteoarthritis and is associated with symptom severity. Synovial membrane inflammation is secondary to cartilage degradation which occurs in the early stage and is located adjacent to cartilage damage. This inflammation is characterized by the invasion and activation of macrophages and lymphocytes, the release in ...
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