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Zhao Y Y Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, - - 2014
Neutrophil elastase (NE) and cathepsin G (CG) contribute to intracellular microbial killing but, if left unchecked and released extracellularly, promote tissue damage. Conversely, mechanisms that constrain neutrophil serine protease activity protect against tissue damage but may have the untoward effect of disabling the microbial killing arsenal. The host elaborates thrombospondin-1 ...
Vaz Michelle M Johns Hopkins University, Oncology, Baltimore, Maryland, United States ; - - 2014
Heightened lung inflammation is a cardinal feature of chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS)-induced macrophage recruitment and activation, accompanied by abnormal secretion of a number of inflammatory cytokines and metalloproteinases (MMPs), play a major role in the pathophysiology of COPD. Heightened lung inflammation is a cardinal feature of ...
Chandler Joshua D JD University of Colorado Denver, Pharmaceutical Sciences, Aurora, Colorado, United States, National Jewish Health, Medicine, Denver, Colorado, United States ; - - 2014
Thiocyanate (SCN) is utilized by the innate immune system but less is known about its impact on inflammation and oxidative stress. Granulocytes oxidize SCN to evolve the bactericidal hypothiocyanous acid (HOSCN), which we previously demonstrated is metabolized by mammalian but not bacterial thioredoxin reductase (TrxR). There is also evidence that ...
Pilling Darrell D Department of Biology, Texas A&M University, College Station, TX 77843; and rgomer@tamu.edu - - 2014
Monocytes leave the blood and enter tissues. In healing wounds and fibrotic lesions, some of the monocytes differentiate into fibroblast-like cells called fibrocytes. In healthy tissues, even though monocytes enter the tissue, for unknown reasons, very few monocytes differentiate into fibrocytes. In this report, we show that fibroblasts from healthy ...
Du Jiangfeng - - 2014
BackgroundIRAK-M is an inhibitor of Toll-like receptor signaling that acts by re-directing IRAK-4 activity to TAK1 independent NF-¿B activation and by inhibition of IRAK-1/IRAK-2 activity. IRAK-M is expressed in monocytes/macrophages and lung epithelial cells. Lack of IRAK-M in mice greatly improves the resistance to nosocomial pneumonia and lung tumors, which ...
Jovic Sandra S Respiratory Medicine & Allergology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, SE-221 85 Lund, Sweden. Electronic address: - - 2014
The glycoprotein osteopontin plays important roles in several states of disease associated with inflammation, for example by recruiting neutrophils but its expression and possible roles in cystic fibrosis (CF) have not been investigated. Immunohistochemistry and ELISA were used to detect osteopontin in clinical samples. In addition, osteopontin-binding and functional interference ...
Dreymueller Daniela D RWTH Aachen - - 2014
Acute and chronic lung inflammation are driven and controlled by several endogenous mediators that undergo proteolytic conversion from surface expressed proteins to soluble variants by a disintegrin and metalloproteinase (ADAM) family members. TNF and epidermal growth factor receptor ligands are just some of the many substrates by which these proteases ...
Atochina-Vasserman Elena N EN University of Pennsylvania, Pulmonary, Allergy and Critical Care Medicine, Philadelphia, Pennsylvania, United States ; - - 2014
Pulmonary lymphangioleiomyomatosis (LAM) is a rare lung disease caused by mutations of the tumor suppressor genes Tuberous Sclerosis Complex (TSC1 or TSC2). LAM affects almost exclusively women and is characterized by neoplastic growth of atypical smooth muscle-like TSC2-null LAM cells in the pulmonary interstitium, cystic destruction of lung parenchyma, and ...
Yao S S Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, - - 2014
Respiratory syncytial virus (RSV) infection is a leading cause of severe lower respiratory tract illness in young infants, the elderly and immunocompromised individuals. We demonstrate here that the co-inhibitory molecule programmed cell death 1 (PD-1) is selectively upregulated on T cells within the respiratory tract during both murine and human ...
Volckaert Thomas T Department of Pediatrics, Division of Cell Biology, National Jewish Health, Denver, CO, 80206, - - 2014
The adaptation to terrestrial life required the development of an organ capable of efficient air-blood gas exchange. To meet the metabolic load of cellular respiration, the mammalian respiratory system has evolved from a relatively simple structure, similar to the two-tube amphibian lung, to a highly complex tree-like system of branched ...
Gallelli Luca - - 2014
Lung cancer is characterized by a high mortality rate probably attributable to early metastasis. Oxidative stress is involved in development and progression of lung cancer, through cellular and molecular mechanisms which at least in part overlap with proinflammatory pathways. Simvastatin is a statin with pleiotropic effects that can also act ...
Chen Xu X Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, P.R. - - 2014
Autophagy is a highly conserved pathway that permits recycling of nutrients within the cell and is rapidly upregulated during starvation or cell stress. Autophagy has been implicated in the pathophysiological process of warm ischemia‑reperfusion injury in the rat lung. Cold ischemia (CI) preservation for lung transplantation also exhibits cell stress ...
Vela-Ramirez Julia E JE Department of Chemical and Biological Engineering, Iowa State University, 2035 Sweeney Hall, Ames, Iowa, 50011, - - 2014
Carbohydrate functionalization of nanoparticles allows for targeting of C-type lectin receptors. This family of pattern recognition receptors expressed on innate immune cells, such as macrophages and dendritic cells, can be used to modulate immune responses. In this work, the in vivo safety profile of carbohydrate-functionalized polyanhydride nanoparticles was analyzed following ...
Huaux François F Louvain centre for Toxicology and Applied Pharmacology (LTAP), Institut de Recherche Experimentale et Clinique (IREC), Université catholique de Louvain, Brussels, - - 2014
Macrophages play a central role in immune and tissue responses of granulomatous lung diseases induced by pathogens and foreign bodies. Circulating monocytes are generally viewed as central precursors of these tissue effector macrophages. Here, we provide evidence that granulomas derive from alveolar macrophages serving as a local reservoir for the ...
Takashima Koji - - 2014
BackgroundAcute respiratory distress syndrome (ARDS) can result in a life-threatening form of respiratory failure, and established, effective pharmacotherapies are therefore urgently required. Quercetin is one of the most common flavonoids found in fruits and vegetables, and has potent anti-inflammatory and anti-oxidant activities. Quercetin has been demonstrated to exhibit cytoprotective effects ...
Gu Chao C 1Department of Respiratory Medicine, Zhejiang Provincial People's Hospital , Hangzhou, Zhejiang , P.R. - - 2014
Abstract In chronic obstructive pulmonary disease (COPD), two major pathological changes that occur are the loss of alveolar structure and airspace enlargement. Type II alveolar epithelial cells (AECII) play a vital role in maintaining alveolar homeostasis and lung tissue repair. Sirtuin 1 (SIRT1), a NAD(+)-dependent histone deacetylase, regulates many pathophysiological ...
Peeters Paul M - - 2014
RationaleMineral particles in the lung cause inflammation and silicosis. In myeloid and bronchial epithelial cells the inflammasome plays a role in responses to crystalline silica. Thioredoxin (TRX) and its inhibitory protein TRX-interacting protein link oxidative stress with inflammasome activation. We investigated inflammasome activation by crystalline silica polymorphs and modulation by ...
Pongrakhananon Varisa V *Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States; Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand; Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States; National Nanotechnology Center, Pathumthani, Thailand *Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States; Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand; Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States; National Nanotechnology Center, Pathumthani, - - 2014
Chronic exposure to single-walled carbon nanotubes (SWCNT) has been reported to induce apoptosis resistance of human lung epithelial cells. Since resistance to apoptosis is a foundation of neoplastic transformation and cancer development, we evaluated the apoptosis resistance characteristic of the exposed lung cells to understand the pathogenesis mechanism. Passage control ...
Liu Ming-Wei MW Department of Emergency, The First Hospital Affiliated to Kunming Medical University, Kunming, P.R. - - 2014
As a Traditional Chinese Medicine, Melilotus extracts have been reported to function as an anti‑inflammatory agent, antioxidant and inhibitor of capillary permeability. The present study aimed to identify the mechanisms by which Melilotus interferes with inflammation‑associated and oxidative stress pathways during sepsis. An animal model of cecal ligation‑perforation (CLP)‑induced sepsis ...
Müller-Redetzky H C HC Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, - - 2014
Anti-inflammatory functions of antibiotics may counteract deleterious hyperinflammation in pneumonia. Moxifloxacin reportedly exhibits immunomodulatory properties, but experimental evidence in pneumonia is lacking. Therefore, we investigated moxifloxacin in comparison with ampicillin regarding pneumonia-associated pulmonary and systemic inflammation and lung injury. Ex vivo infected human lung tissue and mice with pneumococcal pneumonia ...
Costa Ana - - 2014
Lung macrophages present an effective role on innate and immune response through specific and non-specific mechanisms, namely phagocytosis, antigen processing and presentation through major histocompatibility complex, activation of T cells and inflammatory cytokines release. Despite their protective role against injury in normal condition, they can cause several lung conditions, since ...
Han Wei W Vanderbilt university, Pulmonary Medicine, Nashville, Tennessee, United States ; - - 2014
Characterization of markers that identify activated macrophages could advance understanding of inflammatory lung diseases and facilitate development of novel methodologies for monitoring disease activity. We investigated whether folate receptor beta (FRβ) expression could be used to identify and quantify activated macrophages in the lungs during acute inflammation induced by E. ...
Andersson-Sjöland Annika A Lung Biology, Department of Experimental Medical Sciences, BMC D12, Lund University, Lund 221 84, - - 2014
Versican is a proteoglycan that has many different roles in tissue homeostasis and inflammation. The biochemical structure is comprised of four different types of the core protein with attached glycosaminoglycans that can be sulphated to various extents and has the capacity to regulate differentiation of different cell types, migration, cell ...
McElvaney Oliver J OJ Respiratory Research Division, Royal College of Surgeons in Ireland, ERC Beaumont Hospital, Dublin 9, - - 2015
The chemokine interleukin-8 (CXCL8) is a key mediator of inflammation in airways of patients with cystic fibrosis (CF). Glycosaminoglycans (GAGs) possess the ability to influence the chemokine profile of the CF lung by binding CXCL8 and protecting it from proteolytic degradation. CXCL8 is maintained in an active state by this ...
Qin Qingwu Q Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. - - 2014
Nerve growth factor (NGF) and dendritic cells (DCs) have been hypothesized to modulate T cell responses in a mouse model of asthma. However, whether NGF plays a role in regulating the maturation and polarization of lung DCs remains unclear. In the present study, the effect of NGF inhibition on the ...
Singh Rajesh K - - 2014
BackgroundNeutrophils are a critical part of the innate immune system. Their ability to migrate into infected or injured tissues precedes their role in microbial killing and clearance. We have previously shown that Rab27a can promote neutrophil migration by facilitating uropod release through protease secretion from primary granule exocytosis at the ...
Li Jiu-Rong JR Department of Respiratory Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, - - 2014
Aim:Interleukin-22 (IL-22) exhibits both proinflammatory and anti-inflammatory properties in various biological processes. In this study we explored the effects of exogenous recombinant IL-22 (rIL-22) on cigarette smoke (CS)-induced airway inflammation in mice.Methods:Male C57BL/6 mice were divided into groups: (1) CS group exposed to tobacco smoke for 3 consecutive days, (2) ...
Bantikassegn Amlak A Yale University, New Haven, Connecticut, United States ; - - 2014
Genetically engineered mouse models of lung adenocarcinoma have proven invaluable for understanding mechanisms of tumorigenesis, therapy response, and drug resistance. However, mechanistic studies focused on studying these processes in tumor-bearing mouse lungs are confounded by the fact that, in most cases, relevant signaling pathways are analyzed in whole lung preparations, ...
Kambara Kenta K Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan; First Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, - - 2014
Although phenotypically polarized macrophages are now generally classified into two major subtypes termed proinflammatory M1 and anti-inflammatory M2 macrophages, a contributory role of lung M2 macrophages in the pathophysiological features of acute lung injury is not fully understood. Herein, we show in an endotoxemic murine model that M2 macrophages serve ...
Geraghty Patrick P Mount Sinai Roosevelt, Pulmonary Division, New York, New York, United States ; - - 2014
Rationale: α-1 antitrypsin (A1AT) was identified as a plasma protease inhibitor; however, it is now recognized as a multi-functional protein that modulates immunity, inflammation, proteostasis, apoptosis and cellular senescence. Like A1AT, protein phosphatase 2A (PP2A), a major serine-threonine phosphatase, regulates similar biological processes and plays a key role in COPD. ...
François Antoine A ImmunoRhumatologie Moléculaire, INSERM UMR S1109, Université de Strasbourg; Fédération de Médecine Translationnelle de Strasbourg, Centre National de Référence pour les Maladies Auto-immunes Systémiques Rares, Service de Rhumatologie, CHU Strasbourg; Centre de Recherche d'Immunologie et d'Hématologie, Strasbourg, - - 2014
Idiopathic pulmonary fibrosis (IPF) is a progressive devastating, yet untreatable fibrotic disease of unknown origin. We investigated the contribution of the B-cell activating factor (BAFF), a TNF family member recently implicated in the regulation of pathogenic IL-17-producing cells in autoimmune diseases. The contribution of BAFF was assessed in a murine ...
Gowdy K M KM Division of Intramural Research, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, - - 2014
Scavenger receptor B-I (SR-BI) is a multirecognition receptor that regulates cholesterol trafficking and cardiovascular inflammation. Although it is expressed by neutrophils (PMNs) and lung-resident cells, no role for SR-BI has been defined in pulmonary immunity. Herein, we report that, compared with SR-BI(+/+) counterparts, SR-BI(-/-) mice suffer markedly increased mortality during ...
Baldan Angel A Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095; Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University, St. Louis, MO - - 2014
Many metabolic diseases, including atherosclerosis, type 2 diabetes, pulmonary alveolar proteinosis, and obesity, have a chronic inflammatory component involving both innate and adaptive immunity. Mice lacking the ATP-binding cassette transporter G1 (ABCG1) develop chronic inflammation in the lungs, which is associated with the lipid accumulation (cholesterol, cholesterol ester, and phospholipid) ...
Mokra Daniela D Department of Physiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Mala Hora 4, Martin SK-03601, Slovakia. Electronic address: - - 2014
Acute respiratory distress syndrome (ARDS) and its milder form acute lung injury (ALI) may result from various diseases and situations including sepsis, pneumonia, trauma, acute pancreatitis, aspiration of gastric contents, near-drowning etc. ALI/ARDS is characterized by diffuse alveolar injury, lung edema formation, neutrophil-derived inflammation, and surfactant dysfunction. Clinically, ALI/ARDS is ...
Rodríguez Francisco F Unit of Veterinary Histology and Pathology, Institute for Animal Health, Veterinary School, Universidad de Las Palmas de Gran Canaria, 35413, Arucas, Gran Canaria, Spain, - - 2014
Cytokine expression in the lung can play an important role during Mycoplasma bovis infection through leukocyte recruitment and activation, and the induction of a broad array of inflammatory mediators. To gain further insight into the pathogenesis of M. bovis-associated pneumonia, cytokine expression was examined, by immunohistochemical methods in formalin-fixed, paraffin ...
Villar Jesús - - 2014
IntroductionThe mechanisms of lung repair and fibrosis in the acute respiratory distress syndrome (ARDS) are poorly known. Since the role of WNT/ß-catenin signaling appears to be central to lung healing and fibrosis, we hypothesized that this pathway is activated very early in the lungs after sepsis.MethodsWe tested our hypothesis using ...
Qing Danielle Y DY University of Pennsylvania, Philadelphia, Pennsylvania, United States ; - - 2014
Abstract Rationale: RBC transfusions are associated with increased risk of ARDS in the critically ill, yet the mechanisms for enhanced susceptibility to ARDS conferred by RBC transfusions remain unknown. Objective: To determine the mechanisms of lung EC HMGB1 release following exposure to RBCs and to determine whether RBC transfusion increases ...
Sutherland Tara E TE Institute of Immunology and Infection Research, Centre for Immunity Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, - - 2014
Enzymatically inactive chitinase-like proteins (CLPs) such as BRP-39, Ym1 and Ym2 are established markers of immune activation and pathology, yet their functions are essentially unknown. We found that Ym1 and Ym2 induced the accumulation of neutrophils through the expansion of γδ T cell populations that produced interleukin 17 (IL-17). While ...
Hu Jie J Chemical Biology Research Center at College of Pharmacy Sciences, Wenzhou Medical University, University Town, Wenzhou, Zhejiang, 325035, P.R. - - 2014
Quinazoline has been reported to exhibit multiple bioactivities. The aim of this study was to discovery new quinazoline derivatives with preventive effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) via anti-inflammatory actions. Thirty three 4-amino quinazolin derivatives were synthesized and screened for anti-inflammatory activities in LPS-induced macrophages. The most potent ...
Ren Yahao - - 2014
The organic chemicals present in Asian sand dust (ASD) might contribute to the aggravation of lung eosinophila. Therefore, the aggravating effects of the Tar fraction from ASD on ovalbumin (OVA)-induced lung eosinophilia were investigated. The Tar fraction was extracted from ASD collected from the atmosphere in Fukuoka, Japan. ASD collected ...
Yang Zhiping Z Department of Environmental Health, Harvard School of Public Health, Boston, United - - 2014
To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections. Female and estrogen-treated male mice show greater resistance to pneumococcal pneumonia, seen as greater bacterial clearance, diminished lung inflammation and better survival. In vitro, lung macrophages from ...
Keiser Nicholas W NW Carver College of Medicine, University of Iowa, Department of Anatomy and Cell Biology, Iowa City, Iowa, United States ; - - 2014
Mucociliary clearance (MCC) and submucosal glands (SMGs) are major components of airway innate immunity that have impaired function in cystic fibrosis (CF). Although both of these defense systems develop post-natally in the ferret, the lungs of newborn ferrets remain sterile in the presence of a functioning cystic fibrosis transmembrane conductance ...
Blevins Lance K LK Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC - - 2014
Infection with influenza A virus can lead to increased susceptibility to subsequent bacterial infection, often with Streptococcus pneumoniae. Given the substantial modification of the lung environment that occurs following pathogen infection, there is significant potential for modulation of immune responses. In this study, we show that infection of mice with ...
Zhang Yi Y Department of Geriatrics, Shengjing Hospital of China Medical University, 36 Sanhao Road, Shenyang, 110004, China, - - 2014
Our previous study reported that waltonitone treatment inhibited proliferation and induced apoptosis of lung cancer cells. However, the mechanism of waltonitone-induced toxicity remains unclear. In the present study, we treated H460 and H3255 lung cancer cells using different concentration of waltonitone (0, 10, 20, 30 μmol/L). We observed that waltonitone inhibited ...
Moran Timothy P TP Department of Pediatrics, Duke University Medical Center, Durham, NC - - 2014
Adaptive immune responses to inhaled allergens are induced following CCR7-dependent migration of precursor of dendritic cell (pre-DC)-derived conventional DCs (cDCs) from the lung to regional lymph nodes. However, monocyte-derived (moDCs) in the lung express very low levels of Ccr7 and consequently do not migrate efficiently to LN. To investigate the ...
Che Karlhans F KF Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden ; - - 2014
Rationale: The role of the presumed Th17 cytokine interleukin (IL)-26 in antibacterial host defense of the lungs is not known. Objective: To characterize the role of IL-26 in antibacterial host defense of human lungs. Methods: Intra-bronchial exposure of healthy volunteers to endotoxin and vehicle was performed during bronchoscopy and bronchoalveolar ...
Ahmad Sheikh Fayaz SF Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: - - 2014
Increasing indication is unveiling a role for poly(ADP-ribose) polymerase (PARP)-1 in the regulation of inflammatory/immune responses. The aim of the present study was to determine the potential anti-inflammatory effects of PARP-1 inhibitor 5-aminoisoquinolinone (5-AIQ) to explore the role of PARP-1 inhibitor in a mouse model of carrageenan-induced lung inflammation. A ...
Morty Rory E RE University of Giessen Lung Center - - 2014
Transient receptor potential (TRP) channels are emerging as important players and drug targets in respiratory disease. Amongst the vanilloid-type TRP channels (which includes the six member of the TRPV family), target diseases include cough, asthma, cancer, and more recently, pulmonary edema associated with acute respiratory distress syndrome. Here, we critically ...
Antunes Mariana A - - 2014
We sought to assess whether the effects of mesenchymal stromal cells (MSC) on lung inflammation and remodeling in experimental emphysema would differ according to MSC source and administration route. Emphysema was induced in C57BL/6 mice by intratracheal (IT) administration of porcine pancreatic elastase (0.1 UI) weekly for 1 month. After the ...
Foronjy Robert F - - 2014
BackgroundRespiratory syncytial virus (RSV) infects the lung epithelium where it stimulates the production of numerous host cytokines that are associated with disease burden and acute lung injury. Characterizing the host cytokine response to RSV infection, the regulation of host cytokines and the impact of neutralizing an RSV-inducible cytokine during infection ...
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