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Hurley Killian K Respiratory Research Division, Department of Medicine Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, - - 2014
Alpha-1 antitrypsin (AAT) deficiency (AATD) is characterized by neutrophil-driven lung destruction and early emphysema in a low AAT, and high neutrophil elastase environment in the lungs of affected individuals. In this study, we examined peripheral blood neutrophil apoptosis and showed it to be accelerated in individuals with AATD by a ...
Ryu Min Hyung MH The University of - - 2014
Emerging epidemiological evidence reveals a link between lung disease and exposure to indoor pollutants such as perfluorinated compounds (PFCs). PFC exposure during critical developmental stages may increase asthma susceptibility. Thus, in a murine model we tested the hypothesis that early life and continued exposure to two ubiquitous household PFCs, perfluorooctanoic ...
Subramanian V V Department of Surgery, Washington University School of Medicine, St. Louis, - - 2014
Immune responses against lung-associated self-antigens (self-Ags) are hypothesized to play a role in the development of chronic lung graft rejection. We determined whether immune responses to lung self-Ags, K-alpha-1-tubulin (Kα1T) and Collagen V (Col-V) in the absence of alloimmunity, could promote airway inflammation and fibrosis. Following syngeneic murine orthotopic lung ...
Felder M M ARTORG Center Lung Regeneration Technologies Lab, University of Bern, Murtenstrasse 50, 3010 Bern, Switzerland. - - 2014
Idiopathic pulmonary fibrosis (IPF) remains a major clinical challenge to date. Repeated alveolar epithelial microinjuries are considered as the starting point and the key event in both the development and the progression of IPF. Various pro-fibrotic agents have been identified and shown to cause alveolar damage. In IPF, however, no ...
Duque-Correa María A MA Department of Immunology - - 2014
Lung granulomas develop upon Mycobacterium tuberculosis (Mtb) infection as a hallmark of human tuberculosis (TB). They are structured aggregates consisting mainly of Mtb-infected and -uninfected macrophages and Mtb-specific T cells. The production of NO by granuloma macrophages expressing nitric oxide synthase-2 (NOS2) via l-arginine and oxygen is a key protective ...
Jones Christina V - - 2014
BackgroundLung immaturity due to preterm birth is a significant complication affecting neonatal health. Despite the detrimental effects of supplemental oxygen on alveolar formation, it remains an important treatment for infants with respiratory distress. Macrophages are traditionally associated with the propagation of inflammatory insults, however increased appreciation of their diversity has ...
Small Donna M DM Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Health Sciences Building, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, Northern Ireland, - - 2014
Elafin is a serine protease inhibitor produced by epithelial and immune cells with anti-inflammatory properties. Research has shown that dysregulated protease activity may elicit proteolytic cleavage of elafin, thereby impairing the innate immune function of the protein. The aim of this study was to generate variants of elafin (GG- and ...
Li Liu-Cheng LC Anhui Medical - - 2014
Fibrotic diseases occur in a variety of organs that lead to continuous organ injury, function decline, even failure. Nevertheless, there are currently limited effective treatment options. Galectin-3 (Gal-3) is a pleiotropic lectin which plays an important role in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis. Accumulating evidence indicates that Gal-3 ...
Rosa Arianna Carolina AC Dept. of Drug Science and Technology, University of Turin, Turin, - - 2014
Pulmonary fibrosis, a progressive and lethal lung disease characterized by inflammation and accumulation of extracellular matrix components, is one of major therapeutic challenge, where new therapeutic strategies are warranted. COX inhibitors have been previously utilized to reduce inflammation. Histamine H4 receptor (H4R), largely expressed in haematopoietic cells, has been identified ...
Ward Nicole L NL Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, - - 2014
Innate lymphoid cells (ILCs) are a recently discovered family of innate immune cells belonging to the lymphoid lineage, yet lacking antigen-specific receptors. ILCs were first identified in the intestinal tract, where they contribute to epithelial barrier integrity and host responses to commensal microbes. Teunissen et al. (in the current issue) ...
Larsen Jeppe Madura JM Systems Biology of Immune Regulation, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, - - 2014
Recent studies of healthy human airways have revealed colonization by a distinct commensal bacterial microbiota containing Gram-negative Prevotella spp. However, the immunological properties of these bacteria in the respiratory system remain unknown. Here we compare the innate respiratory immune response to three Gram-negative commensal Prevotella strains (Prevotella melaninogenica, Prevotella nanceiensis ...
Evers Alena A Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Member of the German Centre for Lung Research, Justus-Liebig-University Giessen, Feulgen-Str. 10-12, D-35385, Giessen, - - 2014
Acute rejection and respiratory infections are major risk factors for chronic lung allograft dysfunction (CLAD) after lung transplantation. To shed light on the enigmatic aetiology of CLAD we test the following hypotheses using a new experimental model: 1) Alloimmune-independent pulmonary inflammation reactivates alloimmunity. 2) Alloimmunity enhances the susceptibility of the ...
Gao Fengying F 1Department of Respiratory Medicine, Shanghai JianGong Hospital, Shanghai, P. R. - - 2014
ABSTRACT Background: Acute lung injury (ALI) is a high incidence disease with no effective therapeutic method (mortality rate > 40%). The aim of this study was to find a new and effective therapeutic method for ALI. Methods: After the isolation of human umbilical cord mesenchymal stem cells (HUMSCs) from cesarean ...
Qiu Yu-Ying YY Department of Respiratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, - - 2014
Bronchial asthma is characterized by chronic lung inflammation, airway hyperresponsiveness, and airway remodelling. Astragaloside IV (3-O-β-D-xylopyranosyl-6-O-β-D-glucopyranosyl-cycloastragenol, AST), the primary pure saponin isolated from the root of Astragalus membranaceus, is an effective compound with distinct pharmacological effects including anti-inflammation, immunoregulation, and antifibrosis. However, the effect of AST on asthma remains unclear. ...
Dos Santos Laise Aline Martins LA Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, CPqAM/FIOCRUZ, Brazil. Electronic address: - - 2014
Diethylcarbamazine citrate (DEC) is widely used to treat lymphatic filariasis and Tropical Pulmonary Eosinophilia. A number of studies have reported a possible role in the host immune system, but exactly how DEC exerts this effect is still unknown. The present study reports the effects of DEC pretreatment on NF-κB regulation ...
Wu Qianchao Q Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, PR - - 2014
Betulin, a naturally occurring triterpene, has shown anti-HIV activity, but details on the anti-inflammatory activity are scanty. In this study, we sought to investigate the effect of Betulin on LPS-induced activation of cell lines with relevance for lung inflammation in vitro and on lung inflammation elicited by either LPS or ...
Chang Yoke-Chen YC Department of Pharmacology & Toxicology, Rutgers University, Piscataway, - - 2014
Sulfur mustard (bis(2-chloroethyl) sulfide, SM) is a highly reactive bifunctional alkylating agent inducing edema, inflammation, and the formation of fluid-filled blisters in the skin. Medical countermeasures against SM-induced cutaneous injury have yet to be established. In the present studies, we tested a novel, bifunctional anti-inflammatory prodrug (NDH 4338) designed to ...
Soria Angèle A Sorbonne Universités, UPMC Univ. Paris 06, UMR_S CR7, Centre d'Immunologie et des Maladies Infectieuses Cimi-Paris, F-75013, Paris, France; INSERM U1135, Cimi-Paris, F-75013, Paris, France; Service de dermatologie et allergologie, hôpital Tenon, Assistance Publique Hôpitaux de Paris, 4 rue de la Chine, F-75020, Paris, - - 2014
As the primary protective barrier of the body, the skin plays a crucial role of immune-surveillance through a highly diverse skin immune system. Epidermal and dermal skin layers are particularly rich in antigen presenting cells (APCs): Langerhans cells (LCs) and several subsets of dermal dendritic cells (DCs) endowed with specific ...
Popov Aleksandrov Aleksandra A Department of Ecology, Institute for Biological Research "Sinisa Stankovic" , University of Belgrade, Belgrade , Serbia - - 2014
Abstract Context: Dermal toxicity of coumarin anticoagulant rodenticides, such as warfarin, represents potential risk for workers handling these agents and for individuals applying easily available rodenticides in their households as well. Objective: In this study, proinflammatory effects of repeated epicutaneous administration of warfarin in rats were explored by examining inflammatory ...
Goossens R An RA Contact Allergy Unit, Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Leuven B-3000, Belgium. Electronic address: - - 2014
The local application of pharmaceutical products may induce skin adverse reactions, including allergic contact dermatitis. Indeed, pharmaceutical products are, in general, applied on diseased or inflamed skin, the barrier function of which is often incapacitated, leading to enhanced skin penetration of the applied chemicals. Under these circumstances, even weak allergens ...
Nallapaneni Neelima N NN From the University of Nebraska Medical Center, Department of Internal Medicine, Division of Nephrology; Creighton University Medical Center, Department of Internal Medicine; University of Nebraska Medical Center, Department of Internal Medicine, Division of Hematology and Oncology; VA Nebraska-Western Iowa Health Care System, Department of Internal Medicine; and VA Nebraska-Western Iowa Health Care System, and University of Nebraska Medical Center, Department of Internal Medicine, Division of Hematology and Oncology, Omaha, - - 2014
Ipilimumab, a monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen-4, leading to enhanced T-cell activation and proliferation, is associated with improved overall survival in melanoma. Its use can result in immune-related adverse events, the most common of which are skin rash, diarrhea, and colitis. Ipilimumab-induced hypophysitis is uncommon, mostly involves anterior ...
Gosmann Christina C University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia; - - 2014
Persistent infection with high-risk human papillomaviruses (HPV) causes epithelial hyperplasia that can progress to cancer and is thought to depend on immunosuppressive mechanisms that prevent viral clearance by the host. IL-17 is a cytokine with diverse functions in host defense and in the pathology of autoimmune disorders, chronic inflammatory diseases, ...
Desallais Lucille - - 2014
Interleukin 6 (IL-6) is a pleiotropic cytokine for which preliminary data have suggested that it might contribute to systemic sclerosis (SSc). Our aims were to investigate firstly, IL6 expression in SSc patients, and secondly, the efficacy of both passive and active immunization against IL-6 to reduce skin fibrosis in complementary ...
Epaulard Olivier O French Alternative Energies and Atomic Energy Commission, Division of Immuno-Virology, Institute for Emerging Diseases and Innovative Therapies, Infectious Diseases Models for Innovative Therapies Center, 92265 Fontenay-aux-Roses, France; Unité Mixte de Recherche E1, Université Paris-Sud, 91405 Orsay, France; Vaccine Research Institute, 94010 Créteil, France; Infectious Diseases Unit, Grenoble University Hospital, 38043 Grenoble, - - 2014
Dendritic cells are major APCs that can efficiently prime immune responses. However, the roles of skin-resident Langerhans cells (LCs) in eliciting immune responses have not been fully understood. In this study, we demonstrate for the first time, to our knowledge, that LCs in cynomolgus macaque skin are capable of inducing ...
Witte Ellen E 1] Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Berlin, Germany [2] Psoriasis Research and Treatment Center, University Hospital Charité, Berlin, - - 2014
Psoriasis is a common chronic inflammatory disease with characteristic skin alterations functioning as a model of immune-mediated disorders. Cytokines play a key role in psoriasis pathogenesis. Here, we demonstrated that out of 30 individually quantified cytokines IL-19 showed the strongest differential expression between psoriatic lesions and healthy skin. Cutaneous IL-19 ...
Briant Laurence L CPBS, Centre d׳études d׳agents Pathogènes et Biotechnologies pour la Santé, UMR5236 CNRS, Université Montpellier 1,2, Montpellier, - - 2014
Due to climate change and the propagation of competent arthropods worldwide, arboviruses have become pathogens of major medical importance. Early transmission to vertebrates is initiated by skin puncture and deposition of virus together with arthropod saliva in the epidermis and dermis. Saliva components have the capacity to modulate skin cell ...
Stappers M H T MH Department of Internal Medicine (463), Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The - - 2014
Complicated skin and skin structure infections (cSSSIs) are caused by Gram-positive and Gram-negative, aerobic and anaerobic pathogens, with a polymicrobial aetiology being frequent. Recognition of invading pathogens by the immune system results in the production of pro- and anti-inflammatory cytokines, which are extremely important for intercellular communication and control of ...
Ferreira Felipe S FS Departamento de Química Biológica, Universidade Regional do Cariri , Pimenta, Crato, CE , Brazil - - 2014
Abstract Context: Animals are used for the treatment of diseases caused by inflammatory processes, although few studies evaluate their potential for these purposes. Objectives: To evaluate the anti-inflammatory potential of zootherapeutic products derived from vertebrates used in Brazilian traditional medicine. Material and methods: The species analyzed were Tupinambis merianae, Iguana ...
El-Haj Nura N School of Medicine, Trinity College Dublin, Dublin, - - 2014
Physical blocks (i.e. wearing appropriate clothing), exposure avoidance, and the use of sunscreens are the main methods of photoprotection currently used. However, phytochemical and natural botanical extracts such as polypodium leucotomos, a tropical fern found in Central and South America, demonstrate a strong potential as adjuncts to sunscreen protection. A ...
Tong Philip L PL 1] Centenary Institute, Newtown, NSW, Australia [2] Discipline of Dermatology, The University of Sydney, Camperdown, NSW, Australia [3] Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW, - - 2014
Site-specific differences in skin response to pathogens and in the course of cutaneous inflammatory diseases are well appreciated. The composition and localization of cutaneous leukocytes has been studied extensively using histology and flow cytometry. However, the precise three-dimensional (3D) distribution of distinct immune cell subsets within skin at different body ...
Shen Wei W Laboratory of Immunoregulation - - 2014
The adaptive immune system provides critical defense against pathogenic bacteria. Commensal bacteria have begun to receive much attention in recent years, especially in the gut where there is growing evidence of complex interactions with the adaptive immune system. In the present study, we observed that commensal skin bacteria are recognized ...
Gruber-Wackernagel Alexandra A Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, Graz A-8036, - - 2014
Polymorphous light eruption is an immunologically mediated photodermatosis with high prevalence, particularly among young women in temperate climates, characterized by pruritic skin lesions of variable morphology, occurring in spring or early summer on sun-exposed body sites. A resistance to ultraviolet radiation (UVR)-induced immunosuppression and a subsequent delayed-type hypersensitivity response to ...
Vinter H H Department of Dermatology, Aarhus University Hospital, Aarhus, - - 2014
Application with Aldara(™) cream containing 5% imiquimod stimulates toll-like receptor (TLR) 7/8 on plasmacytoid dendritic cells (pDCs) thereby producing a potent immune-modulatory effect. This has been reported to trigger psoriasis. To establish a human model of Aldara-induced psoriasis-like skin inflammation in psoriatic patients. Non-lesional psoriatic skin of 13 patients was ...
Stifano Giuseppina - - 2014
The crucial role of innate immunity in the pathogenesis of systemic sclerosis (SSc) is well established, and in the past few years the hypothesis that Toll-like receptor 4 (TLR4) activation induced by endogenous ligands is involved in fibrogenesis has been supported by several studies on skin, liver, and kidney fibrosis. ...
Mac-Daniel Laura L Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 75724 Paris Cedex 15, - - 2014
Malarial infection is initiated when the sporozoite form of the Plasmodium parasite is inoculated into the skin by a mosquito. Sporozoites invade hepatocytes in the liver and develop into the erythrocyte-infecting form of the parasite, the cause of clinical blood infection. Protection against parasite development in the liver can be ...
Majewska-Szczepanik Monika M Department of Medical Biology, Faculty of Health Sciences, Jagiellonian University College of Medicine, Krakow, - - 2014
Background: Our previous work showed that epicutaneous (EC) immunization with protein antigen e.g. TNP-conjugated mouse immunoglobulin (TNP-Ig) in the form of a patch prior to hapten sensitization inhibits Th1-mediated contact hypersensitivity (CHS) in mice. We also found that suppression of CHS was mediated by TCRαβ+ CD4+ CD8+ T suppressor cells ...
Wölfle Ute U Skintegral Research Center, Department of Dermatology, University Medical Center Freiburg, Freiburg, - - 2014
Reactive oxygen and nitrogen species (ROS/RNS) which may exist as radicals or nonradicals, as well as reactive sulfur species and reactive carbon species, play a major role in aging processes and in carcinogenesis. These reactive molecule species (RMS), often referred to as 'free radicals' or oxidants, are partly by-products of ...
Kim Kyung Hu KH Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan, Repulic of - - 2014
Because antioxidants from natural sources may be an effective approach to the treatment and prevention of UV radiation-induced skin damage, the effects of purified exopolymers from Aureobasidium pullulans SM-2001 ("E-AP-SM2001") were evaluated in UVB-induced hairless mice. E-AP-SM2001 consists of 1.7% β-1,3/1,6-glucan, fibrous polysaccharides and other organic materials, such as amino ...
Park Gunhyuk G 1 Department of Life and Nanopharmaceutical Science, Graduate School and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University , Seoul, - - 2014
Abstract Contact dermatitis (CD) is a pattern of inflammatory responses in the skin that occurs through contact with external factors. The clinical picture is a polymorphic pattern of skin inflammation characterized by a wide range of clinical features, including itching, redness, scaling, and erythema. Coriandrum sativum L. (CS), commonly known ...
Guardiola Francisco A FA Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia. 30100. Murcia, - - 2014
Fish skin mucus contains several immune substances that provide the first line of defence against a broad spectrum of pathogens although they are poorly studied to date. Terminal carbohydrate composition and levels of total IgM antibodies, several immune-related enzymes (lysozyme, peroxidase, alkaline phosphatase, esterases, proteases and antiproteases) as well as ...
Kim Chun C Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Centre for Molecular Medicine (CMMC), University of Cologne, Cologne, - - 2014
The nuclear factor kappa B (NF-κB) signalling pathway exhibits both tumour-promoting and tumour-suppressing functions in different tissues and models of carcinogenesis. In particular in epidermal keratinocytes, NF-κB signalling was reported to exert primarily growth inhibitory and tumour-suppressing functions. Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to ...
Odoardi Francesca F 1] Institute for Multiple Sclerosis Research, Department of Neuroimmunology,Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, Göttingen, Germany [2] Max Planck Institute for Experimental Medicine Göttingen, - - 2014
A recent paper published in Nature reports sensory nerve fibers in the skin that give local immune cells important instructions for the organization of an immune response; in this particular case the cooperation between the nervous and immune systems had disastrous consequences, namely an auto-destruction of the skin.
Natarajan Vivek T VT 1] Council for Scientific and Industrial Research (CSIR) Institute of Genomics and Integrative Biology, Delhi, India. [2] Academy of Scientific and Innovative Research, New Delhi, - - 2014
The recurrent interaction of skin with sunlight is an intrinsic constituent of human life, and exhibits both beneficial and detrimental effects. The apparent robust architectural framework of skin conceals remarkable mechanisms that operate at the interface between the surface and environment. In this Review, we discuss three distinct protective mechanisms ...
Chandrasekaran Navin Chandrakanth NC School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, The University of Queensland, Queensland 4072, Australia School of Medicine, Translational Research Institute, The University of Queensland, Wooloongabba, Queensland 4102, - - 2014
Dead Sea and magnesium salt therapy are two of the oldest forms of treatment for skin disease and several other disorders, supported by a body of largely anecdotal evidence. In this paper we review possible pathways for penetration of magnesium ions through the epidermis to reach the circulation, in turn ...
Fan Chunxin C Institute for Marine Biosystem and Neuroscience, International Center for Marine Studies, Shanghai Ocean University, Shanghai, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Shanghai Ocean University, Ministry of Education, Shanghai, - - 2014
The skin mucus of fish acts as the first line of self-protection against pathogens in the aquatic environment and comprises a number of innate immune components. However, the presence of the critical classical complement component C1q, which links the innate and adaptive immune systems of mammalians, has not been explored ...
Mjösberg Jenny J Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, - - 2014
Innate lymphoid cells (ILC) is the collective term for a group of related innate lymphocytes, including NK cells and the more recently appreciated non-NK ILC (ILC1, ILC2 and ILC3). ILC all originate from a common lymphoid progenitor and depend on the common γ-chain of the IL-2 receptor and the transcription ...
Volpe Elisabetta E Department of Immunology, Institut Curie, Paris, France; Laboratory of Neuroimmunology, Fondazione Santa Lucia, Rome, Italy. Electronic address: - - 2014
Thymic stromal lymphopoietin (TSLP) is a major proallergic cytokine that promotes TH2 responses through dendritic cell (DC) activation. Whether it also plays a role in human autoimmune inflammation and associated pathways is not known. In this study we investigated the potential role of several epithelium-derived factors, including TSLP, in inducing ...
Niebuhr M M Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, - - 2014
Atopic dermatitis (AD) and psoriasis patients are frequently colonized with Staphylococcus aureus (S. aureus) that produce the staphylococcal exotoxin α-toxin. However, only patients with AD suffer from bacterial superinfections with this pathogen, which implicates immunological differences in AD vs psoriasis in combating these bacteria. S. aureus recognition is partially mediated by intracellular nucleotide-binding ...
Kawamura Tatsuyoshi T Department of Dermatology, Faculty of Medicine, University of Yamanashi, - - 2014
As the body's most exposed interface with the environment, the skin is constantly challenged by potentially pathogenic microbes, including viruses. To sense the invading viruses, various types of cells resident in the skin express many different pattern-recognition receptors (PRRs) such as C-type lectin receptors (CLRs), Toll-like receptors (TLRs), nucleotide-binding oligomerization ...
Stalder J F JF Department of Dermatology, University Hospital of Nantes, Nantes, - - 2014
The skin is the largest organ of the body, providing a protective barrier against bacteria, chemicals and physical insults while maintaining homeostasis in the internal environment. Such a barrier function the skin ensures protection against excessive water loss. The skin's immune defence consists of several facets, including immediate, non-specific mechanisms ...
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