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Agrawal Rachana R Department of Medicine, University of Virginia Health System, Allergy Division, PO Box 801355, Charlottesville, VA, 22908-1355, USA, - - 2014
Atopic dermatitis (AD) is a chronic inflammatory skin condition with complex etiology that is dependent upon interactions between the host and the environment. Acute skin lesions exhibit the features of a Th2-driven inflammatory disorder, and many patients are highly atopic. The skin barrier plays key roles in immune surveillance and ...
Stock Angus T AT Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, the University of Melbourne, Parkville, Victoria 3010, - - 2014
Infection induces the expression of inflammatory chemokines that recruit immune cells to the site of inflammation. Whereas tissues such as the intestine and skin express unique chemokines during homeostasis, whether different tissues express distinct chemokine profiles during inflammation remains unclear. With this in mind, we performed a comprehensive screen of ...
Pasparakis Manolis M Institute for Genetics, Center for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, - - 2014
Immune responses in the skin are important for host defence against pathogenic microorganisms. However, dysregulated immune reactions can cause chronic inflammatory skin diseases. Extensive crosstalk between the different cellular and microbial components of the skin regulates local immune responses to ensure efficient host defence, to maintain and restore homeostasis, and ...
Mu Zhanglei Z Department of Dermatology, Peking University People's Hospital, No11, Xizhimen South Street, Beijing, 100044, - - 2014
Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific genetic and immunological mechanisms. The rapid development of new techniques in molecular biology had ushered in new discoveries on the role of cytokines, chemokines, and immune cells in the pathogenesis of AD. New polymorphisms of AD are continually being ...
Nakashima Chisa C Department of Dermatology, Kyoto University Graduate School of - - 2014
Although eosinophils have been detected in several human skin diseases in the vicinity of basophils, how eosinophils infiltrate the skin and the role of eosinophils in the development of skin inflammation have yet to be examined. Using murine irritant contact dermatitis (ICD) as a model, we sought to clarify the ...
Chen Lin L Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, IL, - - 2014
Pigment epithelium-derived factor (PEDF) is a multifunctional factor with potent anti-angiogenic activity that may play a role in skin homeostasis and wound healing. Analysis of PEDF levels demonstrated that PEDF levels are high in normal skin but quite low in early wounds. As previous studies have suggested that keratinocytes can produce PEDF, ...
Feller Liviu - - 2014
The presence of melanocytes in the oral epithelium is a well-established fact, but their physiological functions are not well defined. Melanin provides protection from environmental stressors such as ultraviolet radiation and reactive oxygen species; and melanocytes function as stress-sensors having the capacity both to react to and to produce a ...
Sumida Hayakazu H Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, - - 2014
Psoriasis is an inflammatory skin disease with accelerated epidermal cell turnover. Neutrophil accumulation in the skin is one of the histological characteristics of psoriasis. However, the precise mechanism and role of neutrophil infiltration remain largely unknown. In this article, we show that orchestrated action of CXCR2 and leukotriene B4 receptor ...
Lowes Michelle A MA Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10065; email: lowesm@rockefeller.edu , farinam@rockefeller.edu , - - 2014
The skin is the front line of defense against insult and injury and contains many epidermal and immune elements that comprise the skin-associated lymphoid tissue (SALT). The reaction of these components to injury allows an effective cutaneous response to restore homeostasis. Psoriasis vulgaris is the best-understood and most accessible human ...
Kim Bora B Skin & Bio Research, Ellead Co., Ltd., 325, Hwangsaeul-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-824, Republic of - - 2014
Atopic dermatitis, which is related to dermatologic disorders and is associated with skin barrier dysfunction, represents an epidemic problem demanding effective therapeutic strategies. In the present study, we showed that the treatment with Eruca sativa extract resulted in a significant increase in the transactivation activity of peroxisome proliferator-activated receptor (PPAR) ...
Hendriks Anke G M AG Department of Dermatology, Radboud University Medical Center, Nijmegen, The - - 2014
Background: In healthy skin, tape stripping induces a transient wave of histological changes resembling immune-mediated skin diseases, such as psoriasis. The response to surface trauma may harbor mechanisms which are also relevant to the development of Koebner-positive skin disorders. However, studies on newly discovered drivers of inflammation in regenerative skin ...
Danso Mogbekeloluwa O MO Department of Drug Delivery Technology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The - - 2014
Atopic dermatitis (AD) is a chronic inflammatory skin disease in which the skin barrier function is disrupted. In this inflammatory AD environment, cytokines are up-regulated, but the cytokine effect on the AD skin barrier is not fully understood. We aimed to investigate the influence of Th2 (IL-4, IL-13, IL-31) and ...
Kimber Ian I Faculty of Life - - 2014
The skin has a sophisticated and highly orchestrated immune system. The ability of proteins encountered at skin surfaces to access that immune system remains controversial, however. In this article the question considered is whether proteins encountered epicutaneously (on the skin) at abraded or tape-stripped skin surfaces, but also at sites ...
Nakajima Saeko S Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, - - 2014
Atopic dermatitis (AD) is generally regarded as a Th2-mediated inflammatory skin disease. Although the number of interleukin (IL)-17A-producing cells is increased in the peripheral blood and in acute skin lesion of AD patients, the role of IL-17A in the pathogenesis of AD remains unclear. To clarify this issue, we used ...
McNeill Eileen E Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, London, WC2A 3LY, - - 2014
The S100A8/A9 heterodimer is expressed by myeloid cells where its function has been extensively investigated. Immune cell S100A8/A9 promotes pro-inflammatory effects and its absence is often associated with lack of leukocyte recruitment resulting in protection in terms of disease progression. S100A8/A9 is also expressed by certain epithelia, either constitutively as ...
Kuhn Annegret A Department of Dermatology, University of Muenster, Von-Esmarch-Strasse 58, 48149, Muenster, Germany, - - 2014
The underlying pathomechanisms of lupus erythematosus (LE), a multifactorial autoimmune disease, remain elusive. Due to the clinical evidence demonstrating a clear relationship between ultraviolet (UV) light exposure and skin lesions of LE, photosensitivity has been proven to be an important factor in the pathogenesis of the disease. Standardised photoprovocation with ...
Abramo Francesca - - 2014
Despite the precise pathogenesis of atopic dermatitis (AD) is still unknown, an immune dysregulation that causes Th2-predominant inflammation and an intrinsic defect in skin barrier function are currently the two major hypotheses, according to the so-called outside-inside-outside model. Mast cells (MCs) are involved in AD both by releasing Th2 polarizing ...
Guardiola Francisco A FA Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, 30100 Murcia, - - 2014
Mucosal surfaces of fish, including skin, gill and gut, contain numerous immune substances poorly studied that act as the first line of defence against a broad spectrum of pathogens. This study aimed to identify and characterize for the first time different constitutive humoral defence mechanisms of the skin mucus of ...
Gao Xinghua X Department of Dermatology, the First Hospital of China Medical University, Shenyang, 110001, China, - - 2014
Hyperthermia is a condition characterized by increased body temperature as a consequence of failed thermoregulation. Hyperthermia occurs when a body produces or absorbs more heat than it dissipates. Hyperthermia also elicits various effects on the physiology of living cells. For instance, fever-range temperature (39 °C to 40 °C) can modulate ...
Nakatsuji Teruaki T Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, California, - - 2014
The microbial community inhabiting skin is an important part of its defense, acting to control immune responses and to influence susceptibility to pathogens. In this issue, Volz et al. report that Vitreoscilla filiformis extracts modulate mouse cutaneous inflammatory responses induces of interleukin-10 production in dendritic cells and priming of regulatory ...
Park Kwan Hee KH College of Pharmacy, Chung-Ang - - 2014
The roots of Rosa multiflora THUNB. (RM) has been used in oriental traditional medicines as remedies for scabies, rheumatic arthralgia and stomatitis which were practicably related with today's inflammatory and allergic diseases. In the present study, we evaluated whether RM root extract (RME) and its major constituent, 2-(3,4-dihydroxyphenyl)-6-(4-hydroxyphenyl)-8-(2,4-dihydroxyphenyl)-2,3-trans-6,7-cis-7,8-trans-3,4,7,8-tetrahydro-2H,6H-pyrano[2,3-f] chromene-3,7,9-triol (RM-3) ...
Kezic Sanja S Coronel Institute of Occupational Health, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The - - 2014
The skin represents the largest organ of the body and provides a vital interface between the body and the environment. Hereditary and acquired alterations of structural proteins and lipids of the stratum corneum and epidermal tight junctions leading to a diminished skin barrier function are major causative factors for a ...
Scholz Felix F Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, Minnesota, United States of - - 2014
Barrier surfaces, such as the intestinal lining and the skin, are colonized by a diverse community of commensal microorganisms. Although commensal microorganisms clearly impact the host immune system, whether the immune system also shapes the commensal community is poorly understood. We used 16S rDNA deep sequencing to test whether mice ...
Küng Denise D Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, - - 2014
Microbial communities can augment host immune responses and probiotic therapies are under development to prevent or treat diseases of humans, crops, livestock, and wildlife including an emerging fungal disease of amphibians, chytridiomycosis. However, little is known about the stability of host-associated microbiota, or how the microbiota is structured by innate ...
Mahapatra Subhashree S Department for Pediatric Pneumology, Allergology and Neonatology, Medical School Hannover, Hannover, - - 2014
Histamine drives pruritus in allergic skin diseases which clinically constitutes a most disruptive symptom. Skin pathology in allergic skin diseases is crucially influenced by different T-helper subsets. However, the contribution of different histamine-receptors to T-helper cell dependent skin pathology has not been definitively answered. Models which can specifically address the ...
Ismail Aimen A School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, - - 2014
Interferons (IFNs) are a family of naturally existing glycoproteins known for their antiviral activity and their ability to influence the behavior of normal and transformed cell types. Type I Interferons include IFN- α and IFN- β . Currently, IFN- α has numerous approved antitumor applications, including malignant melanoma, in which ...
Zgraggen Silvana S Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, - - 2014
Inflammatory angiogenesis and vascular remodeling play key roles in the chronic inflammatory skin disease psoriasis, but little is known about the molecular mediators of vascular activation. Based on the reported elevated mRNA levels of the angiogenic chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 in psoriasis, we investigated the ...
Fontana Judith M JM Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, - - 2014
KSHV is the etiologic agent for Kaposi's sarcoma (KS), a neoplasm that manifests most aggressively as multifocal lesions on parts of human skin with a propensity for inflammatory reactivity. However, mechanisms that control evolution of KS from a benign hyperplasia to the histologically complex cutaneous lesion remain unknown. In this ...
Bernard Quentin Q EA7290, Virulence Bacterienne Precoce, Groupe Borréliose de Lyme, Institut de Bacteriologie, Universite de Strasbourg, Strasbourg, - - 2013
The skin is a critical barrier between hosts and pathogens in arthropod-borne diseases. It harbors many resident cells and specific immune cells to arrest or limit infections by secreting inflammatory molecules or by directly killing pathogens. However, some pathogens are able to use specific skin cells and arthropod saliva for ...
Musharrafieh Rami R Center for Evolutionary and Theoretical Immunology, University of New Mexico, Albuquerque, NM, - - 2013
Commensal microorganisms live in association with the mucosal surfaces of all vertebrates. The skin of teleost fish is known to harbor commensals. In this study we report for the first time the presence of an intracellular Gram positive bacteria, Staphylococcus warneri that resides in the skin epidermis of rainbow trout ...
Khan Abdul Quaiyoom AQ a Molecular Carcinogenesis and Chemoprevention Division, Department of Medical Elementology and Toxicology, Faculty of Science , Jamia Hamdard (Hamdard University) , New Delhi , - - 2013
Silibinin is a major bioactive flavonolignan present in milk thistle (Silybum marianum) that possesses antioxidant, antiinflammatory, and anticarcinogenic activity. However, the precise underlying mechanism remains to be elucidated. The present study was designed to investigate underlying molecular mechanism for antitumorigenic potential of silibinin against chemically induced skin tumorigenesis in Swiss ...
Oršolić Nada N Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia. Electronic address: - - 2013
Thermal imaging has been utilized, both preclinically and clinically, as a tool for assessing inflammation. Psoriasis is a chronic inflammatory skin disease characterized by hyperkeratosis, dermal inflammatory infiltrate and increased angiogenesis. The aim of the present study was to assess usefulness of thermography in psoriatic lesion regression after topically treatment ...
Schlereth Tanja T Department of Neurology, Langenbeckstr, 1, D-55131 Mainz, Germany. Electronic address: - - 2013
Acute Complex Regional Pain Syndrome (CRPS) is associated with signs of inflammation such as increased skin temperature, oedema, skin colour changes and pain. Pro-inflammatory cytokines (tumour necrosis factor-α (TNF-α), interleukin-2 (IL-2), IL-1beta, IL-6) are up-regulated, whereas anti-inflammatory cytokines (IL-4, IL-10) are diminished. Adaptive immunity seems to be involved in CRPS ...
Worm Margitta M Dept. of Dermatology, Charité - University medicine, Berlin, Berlin, - - 2013
Contact dermatitis is one of the most frequent pathological manifestations of the skin and plays a central role in clinical and experimental dermatology. The IL-1 family consists a large group of cytokines which currently contains 11 members with different pro- and anti-inflammatory properties. Among the more pro-inflammatory acting cytokines from ...
Ishizaki Masayuki M Department of Immunology, Graduate School of Pharmaceutical Sciences Hokkaido University, Sapporo 060-0812, - - 2013
Tyrosine kinase 2 (Tyk2), a member of the Jak kinase family, mediates signals triggered by various cytokines, which are related to the pathogenesis of psoriasis. In this study, we investigated the role of Tyk2 in IL-23-induced psoriasis-like skin inflammation. Tyk2(-/-) mice when injected with IL-23 showed significantly reduced ear skin ...
Lauriano E R ER Department of Environmental Sciences, Territorial, Food and Health Security (S.A.S.T.A.S.), Viale Stagno d'Alcontres 31, University of Messina, I-98166 Messina, Italy. Electronic address: - - 2013
The skin is the primary interface between the body and the environment, and has a central role in host defence. In the epidermis, Langerhans' cells form an interconnecting network of dendritic cells, that play a central role within inflammatory and immune responses of terrestrial and aquatic mammals, but few studies ...
Yin Qili Q Department of Immunology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University , Shanghai , People's Republic of - - 2013
Abstract Photosensitivity represents a common feature for most forms of lupus erythematosus (LE) including cutaneous LE. Skin inflammatory infiltrates in response to ultraviolet (UV) exposure are closely involved in the development of skin lesions of LE patients. Skin-infiltrating plasmacytoid dendritic cells (pDCs), considered as a hallmark of cutaneous LE, contribute ...
Goebel Carsten C The Procter & Gamble Co., Central Product Safety and Communications, Cincinnati, OH, USA; The Procter & Gamble Co., Central Product Safety and Communications, Darmstadt, Germany. Electronic address: - - 2013
The strong sensitizing potencies of the most important primary intermediates of oxidative hair dyes, p-phenylenediamine (PPD) and p-toluylenediamine (PTD, i.e. 2-methyl-PPD) are well established. They are considered as the key sensitizers in hair dye allergic contact dermatitis. While modification of their molecular structure is expected to alter their sensitizing properties, ...
Salimi Maryam - - 2013
Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce the type 2 cytokines IL-5 and IL-13. Skin-derived ILC2s express the IL-33 receptor ST2, which is ...
Benyacoub J - - 2013
The gut intestinal tract harbours a complex microbiota. Disturbances in the microbiota composition have been associated with several immune dysfunctions such as inflammatory diseases. Specific strains of probiotics have shown to beneficially influence the composition and/or metabolic activity of the endogenous microbiota. Taking advantage of the plasticity of the immune ...
Weiss Richard - - 2013
This review summarizes recent preclinical and human studies evaluating allergen-specific immunotherapy via the transcutaneous route, and provides a rationale for the application of modified allergens with reduced allergenicity. Furthermore, it covers approaches to generate hypoallergenic conjugates for specific dendritic cell targeting. Efficacy and safety of specific immunotherapy by application of ...
Lü Aijun A a School of Life Sciences , Jiangsu Normal University , Xuzhou , 221116 , - - 2013
Abstract Skin is an important innate immune organ in fish; however, little is known about the skin's immune response to infectious pathogens. We conducted a comparative analysis of the acute immune response of Zebrafish Danio rerio skin against gram-positive (Staphylococcus chromogenes) and gram-negative (Citrobacter freundii) bacterial infections. Gene expression profiles ...
Roby Keith D KD Department of Medicine, Division of Dermatology University of California, San Diego 9500 Gilman Drive # 0869 La Jolla, CA - - 2013
Cathelicidin antimicrobial peptide is an important mediator of the innate immune response. In addition to its potent antimicrobial activity, cathelicidin has been shown to have chemoattractant and angiogenic properties. Recent research has demonstrated that, in addition to its aforementioned functions, cathelicidin plays an important role in the complex pathogenesis of ...
Leyva-Castillo Juan Manuel - - 2013
Thymic stromal lymphopoietin (TSLP) has emerged as a key initiator in Th2 immune responses, but the TSLP-driven immune cascade leading to Th2 initiation remains to be delineated. Here, by dissecting the cellular network triggered by mouse skin TSLP in vivo, we uncover that TSLP-promoted IL-4 induction in CD4(+) T cells ...
Mollah Shamim - - 2013
Skin-derived dendritic cells (DC) are potent antigen presenting cells with critical roles in both adaptive immunity and tolerance to self. Skin DC carry antigens and constitutively migrate to the skin draining lymph nodes (LN). In mice, Langerin-CD11b- dermal DC are a low-frequency, heterogeneous, migratory DC subset that traffic to LN ...
Tay Szun S SS Centenary Institute, Locked Bag 6, Newtown, NSW 2042 - - 2014
The skin provides an effective physical and biological barrier against environmental and pathogenic insults whilst ensuring tolerance against commensal microbes. This protection is afforded by the unique anatomy and cellular composition of the skin, particularly the vast network of skin-associated immune cells. These include the long-appreciated tissue-resident macrophages, dendritic cells, ...
Darling Alanna R AR Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, - - 2014
Individuals with atopic dermatitis (AD) are susceptible to a severe, potentially fatal, systemic infection and inflammatory response following exposure to Vaccinia virus (VV). IL-10 acts both as an inducer of Th2 responses and as a regulator of T cell activation. It has been shown to limit skin inflammation elicited by ...
Abtin Arby A 1] The Centenary Institute, Newtown, New South Wales, Australia. - - 2014
Transendothelial migration of neutrophils in postcapillary venules is a key event in the inflammatory response against pathogens and tissue damage. The precise regulation of this process is incompletely understood. We report that perivascular macrophages are critical for neutrophil migration into skin infected with the pathogen Staphylococcus aureus. Using multiphoton intravital ...
Du Jihui - - 2013
ΔNp63 is known to be critical in skin development and cancer, however, how it triggers proliferation and inflammation in vivo remains to be elucidated. Here, we find that induced ΔNp63 expression in skin of transgenic mice (TG) results in a hyperproliferative epidermis coupled with inflammatory infiltrates. In situ, infiltrating cells ...
Sanford James A - - 2013
The skin, the human body's largest organ, is home to a diverse and complex variety of innate and adaptive immune functions. Despite this potent immune system present at the cutaneous barrier, the skin encourages colonization by microorganisms. Characterization these microbial communities has enhanced our knowledge of the ecology of organisms ...
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