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Qin Qingwu Q Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. - - 2014
Nerve growth factor (NGF) and dendritic cells (DCs) have been hypothesized to modulate T cell responses in a mouse model of asthma. However, whether NGF plays a role in regulating the maturation and polarization of lung DCs remains unclear. In the present study, the effect of NGF inhibition on the ...
Geraghty Patrick P Mount Sinai Roosevelt, Pulmonary Division, New York, New York, United States ; - - 2014
Rationale: α-1 antitrypsin (A1AT) was identified as a plasma protease inhibitor; however, it is now recognized as a multi-functional protein that modulates immunity, inflammation, proteostasis, apoptosis and cellular senescence. Like A1AT, protein phosphatase 2A (PP2A), a major serine-threonine phosphatase, regulates similar biological processes and plays a key role in COPD. ...
Gowdy K M KM Division of Intramural Research, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, - - 2014
Scavenger receptor B-I (SR-BI) is a multirecognition receptor that regulates cholesterol trafficking and cardiovascular inflammation. Although it is expressed by neutrophils (PMNs) and lung-resident cells, no role for SR-BI has been defined in pulmonary immunity. Herein, we report that, compared with SR-BI(+/+) counterparts, SR-BI(-/-) mice suffer markedly increased mortality during ...
Baldan Angel A Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095; Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University, St. Louis, MO - - 2014
Many metabolic diseases, including atherosclerosis, type 2 diabetes, pulmonary alveolar proteinosis, and obesity, have a chronic inflammatory component involving both innate and adaptive immunity. Mice lacking the ATP-binding cassette transporter G1 (ABCG1) develop chronic inflammation in the lungs, which is associated with the lipid accumulation (cholesterol, cholesterol ester, and phospholipid) ...
Qing Danielle Y DY University of Pennsylvania, Philadelphia, Pennsylvania, United States ; - - 2014
Abstract Rationale: RBC transfusions are associated with increased risk of ARDS in the critically ill, yet the mechanisms for enhanced susceptibility to ARDS conferred by RBC transfusions remain unknown. Objective: To determine the mechanisms of lung EC HMGB1 release following exposure to RBCs and to determine whether RBC transfusion increases ...
Sutherland Tara E TE Institute of Immunology and Infection Research, Centre for Immunity Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, - - 2014
Enzymatically inactive chitinase-like proteins (CLPs) such as BRP-39, Ym1 and Ym2 are established markers of immune activation and pathology, yet their functions are essentially unknown. We found that Ym1 and Ym2 induced the accumulation of neutrophils through the expansion of γδ T cell populations that produced interleukin 17 (IL-17). While ...
Ren Yahao - - 2014
The organic chemicals present in Asian sand dust (ASD) might contribute to the aggravation of lung eosinophila. Therefore, the aggravating effects of the Tar fraction from ASD on ovalbumin (OVA)-induced lung eosinophilia were investigated. The Tar fraction was extracted from ASD collected from the atmosphere in Fukuoka, Japan. ASD collected ...
Hu Jie J Chemical Biology Research Center at College of Pharmacy Sciences, Wenzhou Medical University, University Town, Wenzhou, Zhejiang, 325035, P.R. - - 2014
Quinazoline has been reported to exhibit multiple bioactivities. The aim of this study was to discovery new quinazoline derivatives with preventive effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) via anti-inflammatory actions. Thirty three 4-amino quinazolin derivatives were synthesized and screened for anti-inflammatory activities in LPS-induced macrophages. The most potent ...
Yang Zhiping Z Department of Environmental Health, Harvard School of Public Health, Boston, United - - 2014
To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections. Female and estrogen-treated male mice show greater resistance to pneumococcal pneumonia, seen as greater bacterial clearance, diminished lung inflammation and better survival. In vitro, lung macrophages from ...
Keiser Nicholas W NW Carver College of Medicine, University of Iowa, Department of Anatomy and Cell Biology, Iowa City, Iowa, United States ; - - 2014
Mucociliary clearance (MCC) and submucosal glands (SMGs) are major components of airway innate immunity that have impaired function in cystic fibrosis (CF). Although both of these defense systems develop post-natally in the ferret, the lungs of newborn ferrets remain sterile in the presence of a functioning cystic fibrosis transmembrane conductance ...
Blevins Lance K LK Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC - - 2014
Infection with influenza A virus can lead to increased susceptibility to subsequent bacterial infection, often with Streptococcus pneumoniae. Given the substantial modification of the lung environment that occurs following pathogen infection, there is significant potential for modulation of immune responses. In this study, we show that infection of mice with ...
Zhang Yi Y Department of Geriatrics, Shengjing Hospital of China Medical University, 36 Sanhao Road, Shenyang, 110004, China, - - 2014
Our previous study reported that waltonitone treatment inhibited proliferation and induced apoptosis of lung cancer cells. However, the mechanism of waltonitone-induced toxicity remains unclear. In the present study, we treated H460 and H3255 lung cancer cells using different concentration of waltonitone (0, 10, 20, 30 μmol/L). We observed that waltonitone inhibited ...
Moran Timothy P TP Department of Pediatrics, Duke University Medical Center, Durham, NC - - 2014
Adaptive immune responses to inhaled allergens are induced following CCR7-dependent migration of precursor of dendritic cell (pre-DC)-derived conventional DCs (cDCs) from the lung to regional lymph nodes. However, monocyte-derived (moDCs) in the lung express very low levels of Ccr7 and consequently do not migrate efficiently to LN. To investigate the ...
Che Karlhans F KF Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden ; - - 2014
Rationale: The role of the presumed Th17 cytokine interleukin (IL)-26 in antibacterial host defense of the lungs is not known. Objective: To characterize the role of IL-26 in antibacterial host defense of human lungs. Methods: Intra-bronchial exposure of healthy volunteers to endotoxin and vehicle was performed during bronchoscopy and bronchoalveolar ...
Ahmad Sheikh Fayaz SF Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: - - 2014
Increasing indication is unveiling a role for poly(ADP-ribose) polymerase (PARP)-1 in the regulation of inflammatory/immune responses. The aim of the present study was to determine the potential anti-inflammatory effects of PARP-1 inhibitor 5-aminoisoquinolinone (5-AIQ) to explore the role of PARP-1 inhibitor in a mouse model of carrageenan-induced lung inflammation. A ...
Morty Rory E RE University of Giessen Lung Center - - 2014
Transient receptor potential (TRP) channels are emerging as important players and drug targets in respiratory disease. Amongst the vanilloid-type TRP channels (which includes the six member of the TRPV family), target diseases include cough, asthma, cancer, and more recently, pulmonary edema associated with acute respiratory distress syndrome. Here, we critically ...
Antunes Mariana A - - 2014
We sought to assess whether the effects of mesenchymal stromal cells (MSC) on lung inflammation and remodeling in experimental emphysema would differ according to MSC source and administration route. Emphysema was induced in C57BL/6 mice by intratracheal (IT) administration of porcine pancreatic elastase (0.1 UI) weekly for 1 month. After the ...
Foronjy Robert F - - 2014
BackgroundRespiratory syncytial virus (RSV) infects the lung epithelium where it stimulates the production of numerous host cytokines that are associated with disease burden and acute lung injury. Characterizing the host cytokine response to RSV infection, the regulation of host cytokines and the impact of neutralizing an RSV-inducible cytokine during infection ...
Xia Hongping H Shanghai Jiao Tong University School of Medicine, Neonatology, Shanghai, Shanghai, China ; - - 2014
Current treatments for inflammation associated with bronchopulmonary dysplasia fail to show clinical efficacy. Foxm1, a transcription factor of the Forkhead box family, is a critical mediator of lung development and carcinogenesis, but its role in bronchopulmonary dysplasia-associated pulmonary inflammation is unknown. Immunohistochemistry and RNA analysis were used to assess Foxm1 ...
Knaul Julia K JK Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany ; - - 2014
Rationale: Myeloid cells encompass distinct populations with unique functions during homeostasis and disease. Recently, a novel subset of innate cells, namely myeloid-derived suppressor cells (MDSCs), has been described in cancer, which suppresses T-cell responses and fosters disease progression. The role of MDSCs in infection is insufficiently addressed. Objectives: To examine ...
Zhang Xuchen X Department of Pathology, Yale University School of Medicine, New Haven, Connecticut; VA Connecticut Healthcare System, West Haven, - - 2014
Emphysema is characterized by loss of lung elasticity and irreversible air space enlargement, usually in the later decades of life. The molecular mechanisms of emphysema remain poorly defined. We identified a role for a novel cathepsin, cathepsin E, in promoting emphysema by inducing mitochondrial fission. Unlike previously reported cysteine cathepsins, ...
Rocha Joao J Research Institute for Medicines (iMed.ULisboa), Avenida Prof. Gama Pinto, 1649-003, Lisbon, - - 2014
Erythropoietin (EPO) is an endogenous regulator of erythropoiesis and is given exogenously as a replacement therapy for selected red blood cell disorders. In the past years, EPO has been emerging as a multifunctional, cytoprotective cytokine with anti-apoptotic, anti-inflammatory, and immunomodulatory properties. We aimed to evaluate the cytoprotective effect of rhEPO ...
Huang Huaqiong H 1] Department of Respiratory Disease, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China [2] Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA [3] Children's Research Foundation Institute, Le Bonheur Children's Hospital, Memphis, TN, - - 2014
Respiratory syncytial virus (RSV) infection remains a significant global health burden disproportionately affecting infants and leading to long-term lung disease. Interleukin (IL)-17A has been shown to be involved in regulating viral and allergic lung inflammatory responses, which has led to a more recent interest in its role in RSV infection. ...
Shen Yongbin Y Department of Vascular Surgery, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150086, - - 2014
Citral, a component of lemongrass oil, has been reported to have many pharmacological activities such as anti-bacterial and anti-inflammatory effects. However, the effects of citral on acute lung injury (ALI) and the molecular mechanisms have not been reported. The aim of this study was to detect the effects of citral ...
Wen Zongmei Z Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA - - 2014
Acute lung injury (ALI) is a major component of multiple organ dysfunction syndrome after hemorrhagic shock (HS) resulting from major surgery and trauma. The increased susceptibility in HS patients to the development of ALI suggests not yet fully elucidated mechanisms that enhance proinflammatory responses and/or suppress anti-inflammatory responses in the ...
Lingaraju Madhu Cholenahalli MC Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, U.P. 243 122, - - 2014
Sepsis commonly progresses to acute lung injury (ALI), an inflammatory lung disease with high morbidity and mortality. Septic ALI is characterized by excessive production of proinflammatory mediators. It remained refractory to present therapies and new therapies need to be developed to improve further clinical outcomes. Betulinic acid (BA), a pentacyclic ...
Schneider Christoph C Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology Zurich, Zurich, - - 2014
Tissue-resident macrophages constitute heterogeneous populations with unique functions and distinct gene-expression signatures. While it has been established that they originate mostly from embryonic progenitor cells, the signals that induce a characteristic tissue-specific differentiation program remain unknown. We found that the nuclear receptor PPAR-γ determined the perinatal differentiation and identity of ...
Kelly Ciara - - 2014
The development of small interfering RNA (siRNA) to silence specific genes offers a new means of understanding and treating a range of respiratory diseases, including inflammatory lung disease. The alveolar macrophage (AM) is a key component of the inflammatory process in the lungs, associated with high levels of gene expression ...
Pan Jing J Pharmacology and Toxicology, Medical College of - - 2014
Honokiol is an important bioactive compound found in the bark of Magnolia tree. It is a non-adipogenic PPARγ agonist, and capable of inhibiting the growth of a variety of tumor types both in vitro and in xenograft models. However, to fully appreciate the potential chemopreventive activity of honokiol, a less ...
Parker Dane D Department of Pediatrics, Columbia University, New York, New York, USA - - 2014
We postulated that the activation of proinflammatory signaling by USA300-MRSA is a major factor in the pathogenesis of severe pneumonia and a target for immunomodulation. Local activation of T cells in the lung was a conserved feature of multiple strains of S. aureus, in addition to USA300. The pattern of ...
Nardelli L M LM Laboratory of Pulmonary - - 2014
We investigated the effects of acute hypercapnic acidosis and buffered hypercapnia on lung inflammation and apoptosis in experimental acute lung injury (ALI). Twenty-four hours after paraquat injection, 28 Wistar rats were randomized into four groups (n=7/group): (1) normocapnia (NC, PaCO2=35-45mmHg), ventilated with 0.03%CO2+21%O2+balancedN2; (2) hypercapnic acidosis (HC, PaCO2=60-70mmHg), ventilated with ...
Hurley Killian K Respiratory Research Division, Department of Medicine Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, - - 2014
Alpha-1 antitrypsin (AAT) deficiency (AATD) is characterized by neutrophil-driven lung destruction and early emphysema in a low AAT, and high neutrophil elastase environment in the lungs of affected individuals. In this study, we examined peripheral blood neutrophil apoptosis and showed it to be accelerated in individuals with AATD by a ...
Ryu Min Hyung MH The University of - - 2014
Emerging epidemiological evidence reveals a link between lung disease and exposure to indoor pollutants such as perfluorinated compounds (PFCs). PFC exposure during critical developmental stages may increase asthma susceptibility. Thus, in a murine model we tested the hypothesis that early life and continued exposure to two ubiquitous household PFCs, perfluorooctanoic ...
Subramanian V V Department of Surgery, Washington University School of Medicine, St. Louis, - - 2014
Immune responses against lung-associated self-antigens (self-Ags) are hypothesized to play a role in the development of chronic lung graft rejection. We determined whether immune responses to lung self-Ags, K-alpha-1-tubulin (Kα1T) and Collagen V (Col-V) in the absence of alloimmunity, could promote airway inflammation and fibrosis. Following syngeneic murine orthotopic lung ...
Felder M M ARTORG Center Lung Regeneration Technologies Lab, University of Bern, Murtenstrasse 50, 3010 Bern, Switzerland. - - 2014
Idiopathic pulmonary fibrosis (IPF) remains a major clinical challenge to date. Repeated alveolar epithelial microinjuries are considered as the starting point and the key event in both the development and the progression of IPF. Various pro-fibrotic agents have been identified and shown to cause alveolar damage. In IPF, however, no ...
Duque-Correa María A MA Department of Immunology - - 2014
Lung granulomas develop upon Mycobacterium tuberculosis (Mtb) infection as a hallmark of human tuberculosis (TB). They are structured aggregates consisting mainly of Mtb-infected and -uninfected macrophages and Mtb-specific T cells. The production of NO by granuloma macrophages expressing nitric oxide synthase-2 (NOS2) via l-arginine and oxygen is a key protective ...
Jones Christina V - - 2014
BackgroundLung immaturity due to preterm birth is a significant complication affecting neonatal health. Despite the detrimental effects of supplemental oxygen on alveolar formation, it remains an important treatment for infants with respiratory distress. Macrophages are traditionally associated with the propagation of inflammatory insults, however increased appreciation of their diversity has ...
Small Donna M DM Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Health Sciences Building, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, Northern Ireland, - - 2014
Elafin is a serine protease inhibitor produced by epithelial and immune cells with anti-inflammatory properties. Research has shown that dysregulated protease activity may elicit proteolytic cleavage of elafin, thereby impairing the innate immune function of the protein. The aim of this study was to generate variants of elafin (GG- and ...
Li Liu-Cheng LC Anhui Medical - - 2014
Fibrotic diseases occur in a variety of organs that lead to continuous organ injury, function decline, even failure. Nevertheless, there are currently limited effective treatment options. Galectin-3 (Gal-3) is a pleiotropic lectin which plays an important role in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis. Accumulating evidence indicates that Gal-3 ...
Rosa Arianna Carolina AC Dept. of Drug Science and Technology, University of Turin, Turin, - - 2014
Pulmonary fibrosis, a progressive and lethal lung disease characterized by inflammation and accumulation of extracellular matrix components, is one of major therapeutic challenge, where new therapeutic strategies are warranted. COX inhibitors have been previously utilized to reduce inflammation. Histamine H4 receptor (H4R), largely expressed in haematopoietic cells, has been identified ...
Ward Nicole L NL Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, - - 2014
Innate lymphoid cells (ILCs) are a recently discovered family of innate immune cells belonging to the lymphoid lineage, yet lacking antigen-specific receptors. ILCs were first identified in the intestinal tract, where they contribute to epithelial barrier integrity and host responses to commensal microbes. Teunissen et al. (in the current issue) ...
Larsen Jeppe Madura JM Systems Biology of Immune Regulation, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, - - 2014
Recent studies of healthy human airways have revealed colonization by a distinct commensal bacterial microbiota containing Gram-negative Prevotella spp. However, the immunological properties of these bacteria in the respiratory system remain unknown. Here we compare the innate respiratory immune response to three Gram-negative commensal Prevotella strains (Prevotella melaninogenica, Prevotella nanceiensis ...
Evers Alena A Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Member of the German Centre for Lung Research, Justus-Liebig-University Giessen, Feulgen-Str. 10-12, D-35385, Giessen, - - 2014
Acute rejection and respiratory infections are major risk factors for chronic lung allograft dysfunction (CLAD) after lung transplantation. To shed light on the enigmatic aetiology of CLAD we test the following hypotheses using a new experimental model: 1) Alloimmune-independent pulmonary inflammation reactivates alloimmunity. 2) Alloimmunity enhances the susceptibility of the ...
Shepardson Kelly M KM Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of - - 2014
Hypoxia inducible factor 1α (HIF1α) is the mammalian transcriptional factor that controls metabolism, survival, and innate immunity in response to inflammation and low oxygen. Previous work established that generation of hypoxic microenvironments occurs within the lung during infection with the human fungal pathogen Aspergillus fumigatus. Here we demonstrate that A. ...
Davies Jonathan J Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, - - 2014
Hyperoxic lung injury is characterized by cellular damage from high oxygen concentrations that lead to an inflammatory response in the lung with cellular infiltration and pulmonary edema. Adenosine is a signaling molecule that is generated extracellularly by CD73 in response to injury. Extracellular adenosine signals through cell surface receptors and ...
Hamblin Mark J MJ University of Kansas Hospital, - - 2014
Lovastatin has a unique ability to bind Leukocyte Function Antigen-1 (LFA-1), an integrin necessary for the full expression of inflammatory cytokines induced by the low molecular weight form of the extracellular matrix glycosaminoglycan hyaluronan (LMW HA). We hypothesized that lovastatin could inhibit LMW HA inflammatory signals via interaction with LFA-1, ...
Kim Hyun-Jeong HJ Department of Applied Life Science, The Graduate School, Yonsei University, Seoul, Korea ; Department of Oral Biology, Oral Cancer Research Institute, BK21 PLUS project, Yonsei University College of Dentistry, Seoul, - - 2014
Allium victorialis var. platyphyllum is an edible perennial herb and has been used as a vegetable or as a Korean traditional medicine. Allium species have received much attention owing to their diverse pharmacological properties, including antioxidative, anti-inflammatory, and anticancer activities. However, A. victorialis var. platyphyllum needs more study. The chemopreventive ...
Gao Fengying F 1Department of Respiratory Medicine, Shanghai JianGong Hospital, Shanghai, P. R. - - 2014
ABSTRACT Background: Acute lung injury (ALI) is a high incidence disease with no effective therapeutic method (mortality rate > 40%). The aim of this study was to find a new and effective therapeutic method for ALI. Methods: After the isolation of human umbilical cord mesenchymal stem cells (HUMSCs) from cesarean ...
Qiu Yu-Ying YY Department of Respiratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, - - 2014
Bronchial asthma is characterized by chronic lung inflammation, airway hyperresponsiveness, and airway remodelling. Astragaloside IV (3-O-β-D-xylopyranosyl-6-O-β-D-glucopyranosyl-cycloastragenol, AST), the primary pure saponin isolated from the root of Astragalus membranaceus, is an effective compound with distinct pharmacological effects including anti-inflammation, immunoregulation, and antifibrosis. However, the effect of AST on asthma remains unclear. ...
Dos Santos Laise Aline Martins LA Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, CPqAM/FIOCRUZ, Brazil. Electronic address: - - 2014
Diethylcarbamazine citrate (DEC) is widely used to treat lymphatic filariasis and Tropical Pulmonary Eosinophilia. A number of studies have reported a possible role in the host immune system, but exactly how DEC exerts this effect is still unknown. The present study reports the effects of DEC pretreatment on NF-κB regulation ...
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