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Goossens R An RA Contact Allergy Unit, Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Leuven B-3000, Belgium. Electronic address: - - 2014
The local application of pharmaceutical products may induce skin adverse reactions, including allergic contact dermatitis. Indeed, pharmaceutical products are, in general, applied on diseased or inflamed skin, the barrier function of which is often incapacitated, leading to enhanced skin penetration of the applied chemicals. Under these circumstances, even weak allergens ...
Gosmann Christina C University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia; - - 2014
Persistent infection with high-risk human papillomaviruses (HPV) causes epithelial hyperplasia that can progress to cancer and is thought to depend on immunosuppressive mechanisms that prevent viral clearance by the host. IL-17 is a cytokine with diverse functions in host defense and in the pathology of autoimmune disorders, chronic inflammatory diseases, ...
Desallais Lucille - - 2014
Interleukin 6 (IL-6) is a pleiotropic cytokine for which preliminary data have suggested that it might contribute to systemic sclerosis (SSc). Our aims were to investigate firstly, IL6 expression in SSc patients, and secondly, the efficacy of both passive and active immunization against IL-6 to reduce skin fibrosis in complementary ...
Epaulard Olivier O French Alternative Energies and Atomic Energy Commission, Division of Immuno-Virology, Institute for Emerging Diseases and Innovative Therapies, Infectious Diseases Models for Innovative Therapies Center, 92265 Fontenay-aux-Roses, France; Unité Mixte de Recherche E1, Université Paris-Sud, 91405 Orsay, France; Vaccine Research Institute, 94010 Créteil, France; Infectious Diseases Unit, Grenoble University Hospital, 38043 Grenoble, - - 2014
Dendritic cells are major APCs that can efficiently prime immune responses. However, the roles of skin-resident Langerhans cells (LCs) in eliciting immune responses have not been fully understood. In this study, we demonstrate for the first time, to our knowledge, that LCs in cynomolgus macaque skin are capable of inducing ...
Witte Ellen E 1] Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Berlin, Germany [2] Psoriasis Research and Treatment Center, University Hospital Charité, Berlin, - - 2014
Psoriasis is a common chronic inflammatory disease with characteristic skin alterations functioning as a model of immune-mediated disorders. Cytokines play a key role in psoriasis pathogenesis. Here, we demonstrated that out of 30 individually quantified cytokines IL-19 showed the strongest differential expression between psoriatic lesions and healthy skin. Cutaneous IL-19 ...
Briant Laurence L CPBS, Centre d׳études d׳agents Pathogènes et Biotechnologies pour la Santé, UMR5236 CNRS, Université Montpellier 1,2, Montpellier, - - 2014
Due to climate change and the propagation of competent arthropods worldwide, arboviruses have become pathogens of major medical importance. Early transmission to vertebrates is initiated by skin puncture and deposition of virus together with arthropod saliva in the epidermis and dermis. Saliva components have the capacity to modulate skin cell ...
Stappers M H T MH Department of Internal Medicine (463), Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The - - 2014
Complicated skin and skin structure infections (cSSSIs) are caused by Gram-positive and Gram-negative, aerobic and anaerobic pathogens, with a polymicrobial aetiology being frequent. Recognition of invading pathogens by the immune system results in the production of pro- and anti-inflammatory cytokines, which are extremely important for intercellular communication and control of ...
Ferreira Felipe S FS Departamento de Química Biológica, Universidade Regional do Cariri , Pimenta, Crato, CE , Brazil - - 2014
Abstract Context: Animals are used for the treatment of diseases caused by inflammatory processes, although few studies evaluate their potential for these purposes. Objectives: To evaluate the anti-inflammatory potential of zootherapeutic products derived from vertebrates used in Brazilian traditional medicine. Material and methods: The species analyzed were Tupinambis merianae, Iguana ...
El-Haj Nura N School of Medicine, Trinity College Dublin, Dublin, - - 2014
Physical blocks (i.e. wearing appropriate clothing), exposure avoidance, and the use of sunscreens are the main methods of photoprotection currently used. However, phytochemical and natural botanical extracts such as polypodium leucotomos, a tropical fern found in Central and South America, demonstrate a strong potential as adjuncts to sunscreen protection. A ...
Tong Philip L PL 1] Centenary Institute, Newtown, NSW, Australia [2] Discipline of Dermatology, The University of Sydney, Camperdown, NSW, Australia [3] Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW, - - 2014
Site-specific differences in skin response to pathogens and in the course of cutaneous inflammatory diseases are well appreciated. The composition and localization of cutaneous leukocytes has been studied extensively using histology and flow cytometry. However, the precise three-dimensional (3D) distribution of distinct immune cell subsets within skin at different body ...
Shen Wei W Laboratory of Immunoregulation - - 2014
The adaptive immune system provides critical defense against pathogenic bacteria. Commensal bacteria have begun to receive much attention in recent years, especially in the gut where there is growing evidence of complex interactions with the adaptive immune system. In the present study, we observed that commensal skin bacteria are recognized ...
Gruber-Wackernagel Alexandra A Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, Graz A-8036, - - 2014
Polymorphous light eruption is an immunologically mediated photodermatosis with high prevalence, particularly among young women in temperate climates, characterized by pruritic skin lesions of variable morphology, occurring in spring or early summer on sun-exposed body sites. A resistance to ultraviolet radiation (UVR)-induced immunosuppression and a subsequent delayed-type hypersensitivity response to ...
Vinter H H Department of Dermatology, Aarhus University Hospital, Aarhus, - - 2014
Application with Aldara(™) cream containing 5% imiquimod stimulates toll-like receptor (TLR) 7/8 on plasmacytoid dendritic cells (pDCs) thereby producing a potent immune-modulatory effect. This has been reported to trigger psoriasis. To establish a human model of Aldara-induced psoriasis-like skin inflammation in psoriatic patients. Non-lesional psoriatic skin of 13 patients was ...
Stifano Giuseppina - - 2014
The crucial role of innate immunity in the pathogenesis of systemic sclerosis (SSc) is well established, and in the past few years the hypothesis that Toll-like receptor 4 (TLR4) activation induced by endogenous ligands is involved in fibrogenesis has been supported by several studies on skin, liver, and kidney fibrosis. ...
Mac-Daniel Laura L Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 75724 Paris Cedex 15, - - 2014
Malarial infection is initiated when the sporozoite form of the Plasmodium parasite is inoculated into the skin by a mosquito. Sporozoites invade hepatocytes in the liver and develop into the erythrocyte-infecting form of the parasite, the cause of clinical blood infection. Protection against parasite development in the liver can be ...
Majewska-Szczepanik Monika M Department of Medical Biology, Faculty of Health Sciences, Jagiellonian University College of Medicine, Krakow, - - 2014
Background: Our previous work showed that epicutaneous (EC) immunization with protein antigen e.g. TNP-conjugated mouse immunoglobulin (TNP-Ig) in the form of a patch prior to hapten sensitization inhibits Th1-mediated contact hypersensitivity (CHS) in mice. We also found that suppression of CHS was mediated by TCRαβ+ CD4+ CD8+ T suppressor cells ...
Wölfle Ute U Skintegral Research Center, Department of Dermatology, University Medical Center Freiburg, Freiburg, - - 2014
Reactive oxygen and nitrogen species (ROS/RNS) which may exist as radicals or nonradicals, as well as reactive sulfur species and reactive carbon species, play a major role in aging processes and in carcinogenesis. These reactive molecule species (RMS), often referred to as 'free radicals' or oxidants, are partly by-products of ...
Kim Kyung Hu KH Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan, Repulic of - - 2014
Because antioxidants from natural sources may be an effective approach to the treatment and prevention of UV radiation-induced skin damage, the effects of purified exopolymers from Aureobasidium pullulans SM-2001 ("E-AP-SM2001") were evaluated in UVB-induced hairless mice. E-AP-SM2001 consists of 1.7% β-1,3/1,6-glucan, fibrous polysaccharides and other organic materials, such as amino ...
Park Gunhyuk G 1 Department of Life and Nanopharmaceutical Science, Graduate School and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University , Seoul, - - 2014
Abstract Contact dermatitis (CD) is a pattern of inflammatory responses in the skin that occurs through contact with external factors. The clinical picture is a polymorphic pattern of skin inflammation characterized by a wide range of clinical features, including itching, redness, scaling, and erythema. Coriandrum sativum L. (CS), commonly known ...
Guardiola Francisco A FA Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia. 30100. Murcia, - - 2014
Fish skin mucus contains several immune substances that provide the first line of defence against a broad spectrum of pathogens although they are poorly studied to date. Terminal carbohydrate composition and levels of total IgM antibodies, several immune-related enzymes (lysozyme, peroxidase, alkaline phosphatase, esterases, proteases and antiproteases) as well as ...
Kim Chun C Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Centre for Molecular Medicine (CMMC), University of Cologne, Cologne, - - 2014
The nuclear factor kappa B (NF-κB) signalling pathway exhibits both tumour-promoting and tumour-suppressing functions in different tissues and models of carcinogenesis. In particular in epidermal keratinocytes, NF-κB signalling was reported to exert primarily growth inhibitory and tumour-suppressing functions. Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to ...
Odoardi Francesca F 1] Institute for Multiple Sclerosis Research, Department of Neuroimmunology,Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, Göttingen, Germany [2] Max Planck Institute for Experimental Medicine Göttingen, - - 2014
A recent paper published in Nature reports sensory nerve fibers in the skin that give local immune cells important instructions for the organization of an immune response; in this particular case the cooperation between the nervous and immune systems had disastrous consequences, namely an auto-destruction of the skin.
Natarajan Vivek T VT 1] Council for Scientific and Industrial Research (CSIR) Institute of Genomics and Integrative Biology, Delhi, India. [2] Academy of Scientific and Innovative Research, New Delhi, - - 2014
The recurrent interaction of skin with sunlight is an intrinsic constituent of human life, and exhibits both beneficial and detrimental effects. The apparent robust architectural framework of skin conceals remarkable mechanisms that operate at the interface between the surface and environment. In this Review, we discuss three distinct protective mechanisms ...
Chandrasekaran Navin Chandrakanth NC School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, The University of Queensland, Queensland 4072, Australia School of Medicine, Translational Research Institute, The University of Queensland, Wooloongabba, Queensland 4102, - - 2014
Dead Sea and magnesium salt therapy are two of the oldest forms of treatment for skin disease and several other disorders, supported by a body of largely anecdotal evidence. In this paper we review possible pathways for penetration of magnesium ions through the epidermis to reach the circulation, in turn ...
Fan Chunxin C Institute for Marine Biosystem and Neuroscience, International Center for Marine Studies, Shanghai Ocean University, Shanghai, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Shanghai Ocean University, Ministry of Education, Shanghai, - - 2014
The skin mucus of fish acts as the first line of self-protection against pathogens in the aquatic environment and comprises a number of innate immune components. However, the presence of the critical classical complement component C1q, which links the innate and adaptive immune systems of mammalians, has not been explored ...
Mjösberg Jenny J Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, - - 2014
Innate lymphoid cells (ILC) is the collective term for a group of related innate lymphocytes, including NK cells and the more recently appreciated non-NK ILC (ILC1, ILC2 and ILC3). ILC all originate from a common lymphoid progenitor and depend on the common γ-chain of the IL-2 receptor and the transcription ...
Volpe Elisabetta E Department of Immunology, Institut Curie, Paris, France; Laboratory of Neuroimmunology, Fondazione Santa Lucia, Rome, Italy. Electronic address: - - 2014
Thymic stromal lymphopoietin (TSLP) is a major proallergic cytokine that promotes TH2 responses through dendritic cell (DC) activation. Whether it also plays a role in human autoimmune inflammation and associated pathways is not known. In this study we investigated the potential role of several epithelium-derived factors, including TSLP, in inducing ...
Niebuhr M M Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, - - 2014
Atopic dermatitis (AD) and psoriasis patients are frequently colonized with Staphylococcus aureus (S. aureus) that produce the staphylococcal exotoxin α-toxin. However, only patients with AD suffer from bacterial superinfections with this pathogen, which implicates immunological differences in AD vs psoriasis in combating these bacteria. S. aureus recognition is partially mediated by intracellular nucleotide-binding ...
Kawamura Tatsuyoshi T Department of Dermatology, Faculty of Medicine, University of Yamanashi, - - 2014
As the body's most exposed interface with the environment, the skin is constantly challenged by potentially pathogenic microbes, including viruses. To sense the invading viruses, various types of cells resident in the skin express many different pattern-recognition receptors (PRRs) such as C-type lectin receptors (CLRs), Toll-like receptors (TLRs), nucleotide-binding oligomerization ...
Stalder J F JF Department of Dermatology, University Hospital of Nantes, Nantes, - - 2014
The skin is the largest organ of the body, providing a protective barrier against bacteria, chemicals and physical insults while maintaining homeostasis in the internal environment. Such a barrier function the skin ensures protection against excessive water loss. The skin's immune defence consists of several facets, including immediate, non-specific mechanisms ...
Hornung Thorsten T Department of Dermatology, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, - - 2014
Dermatomyositis (DM) is an autoimmune disease mainly affecting muscle and skin. Typical clinical and laboratory findings include muscle weakness with elevated muscle enzymes, characteristic skin lesions (e.g., Gottron papules, heliotrope erythema, Shawl sign), and specific serum autoantibodies. Recent studies have highlighted the activation of the innate immune system, including high ...
Tatsuno Tomoko T a Research Laboratory , LINTEC Corporation , Warabi-shi , - - 2014
N-methyl-2-pyrrolidone (NMP) is known for its multi-solvent properties. However, its biological, especially immunological significance still remains to be elucidated. In this study, we show for the first time that NMP stimulates the skin immune system by activating epidermal Langerhans cells (LCs). In contrast with the placebo tape, when the NMP-containing ...
Maurya Anil Kumar - - 2014
α-(-)-bisabolol is a natural oily monocyclic sesquiterpene alcohol present in the essential oil has generated considerable interest in chemical and pharmaceutical industries and currently in used in various formulations, mainly in cosmetics. This study was undertaken to evaluate its therapeutic profile against skin inflammation using in-vitro, in-vivo and in silico ...
McKelvey Kelly K Kelly McKelvey, Christopher John Jackson, Meilang Xue, Sutton Arthritis Research Laboratory, Level 10, Kolling Institute, University of Sydney at Royal North Shore Hospital, NSW 2065, - - 2014
Activated protein C (APC) is a physiological anticoagulant, derived from its precursor protein C (PC). Independent of its anticoagulation, APC possesses strong anti-inflammatory, anti-apoptotic and barrier protective properties which appear to be protective in a number of disorders including chronic wound healing. The epidermis is the outermost skin layer and ...
Malissen Bernard B Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Institut National de la Santé et de la Recherche Médicale U1104, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7280, 13288 Marseille, - - 2014
Immune cell populations in the skin are predominantly comprised of dendritic cells (DCs) and macrophages. A lack of consensus regarding how to define these cell types has hampered research in this area. In this Review, we focus on recent advances that, based on ontogeny and global gene-expression profiles, have succeeded ...
Zhuang Yong - - 2014
Inflammaging refers to a continuous, low-grade inflammation associated with aging. Such chronic inflammatory response could build up with time and gradually cause tissue damage. It is considered one of the driving forces for many age-related diseases such as diabetes, atherosclerosis, age-related macular degeneration (AMD), and skin aging. There is mounting ...
Webb Kirsten C KC Department of Dermatology, College of Medicine, University of Illinois at Chicago, Chicago (IL), - - 2014
Depigmentation in vitiligo occurs by progressive loss of melanocytes from the basal layer of the skin, and can be psychologically devastating to patients. T cell-mediated autoimmunity explains the progressive nature of this disease. Rather than being confronted with periods of rapid depigmentation and bouts of repigmentation, patients with long-standing, treatment-resistant ...
Byamba Dashlkhumbe D Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea; Department of Dermatology, School of Medicine, Health Sciences University of Mongolia, Ulaanbaatar, - - 2014
Accumulating evidence has shown that the Toll-like receptor 7 agonist imiquimod (IMQ) induces psoriasiform skin inflammation in mice and that this inflammation is dependent on the IL-23/IL-17 axis. Moreover it has been demonstrated that the main source of IL-17 is not Th17 but is dermal gamma delta (γδ) T cells ...
Yeh Chun-Nan CN GIST team, Department of Surgery, Chang Gung Memorial Hospital, Linkou; Chang Gung University, Taoyuan, - - 2014
Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor (TKI) used for the treatment of renal cell carcinoma and gastrointestinal stromal tumor (GIST), is notorious for cutaneous adverse effects, such as hand-foot skin reaction (HFSR). To explore the underlying mechanism of HFSR, we enrolled 53 sunitinib-treated GIST patients, including 23 HFSR cases, ...
McKee Sara J SJ The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Brisbane, Queensland, - - 2014
The skin is a complex immunological niche providing immunity to invading pathogens while simultaneously maintaining tolerance to innocuous environmental antigens. Consistent with this complex response, the skin is resident to both immunosuppressive and effector cell populations whose activities are tightly regulated. While NKT cells can activate immune responses in the ...
Borkowski Andrew W AW Division of Dermatology, Department of Medicine, University of California, San Diego, La Jolla, California, - - 2014
UV radiation poses a significant risk to human health. The mechanisms that help repair UV-damaged cells have recently been more clearly defined with the observation that Toll-like receptor 3 can sense self RNA released from necrotic keratinocytes following UV damage. TLR3 activation in the skin induces inflammation and increases the ...
Tartar Danielle - - 2014
Phototherapy is often used to treat inflammatory skin conditions such as psoriasis and eczema. Much progress has recently been made in understanding the mechanisms underlying the local, cutaneous immune effects induced by phototherapy. Unlike many immunosuppressive drugs used in the management of inflammatory skin disease, phototherapy not only targets effector ...
Candel Sergio S Departamento de Biología Celular e Histología, Facultad de Biología, Universidad de Murcia, Murcia, Spain; Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, - - 2014
TNFα overexpression has been associated with several chronic inflammatory diseases, including psoriasis, lichen planus, rheumatoid arthritis, and inflammatory bowel disease. Paradoxically, numerous studies have reported new-onset psoriasis and lichen planus following TNFα antagonist therapy. Here, we show that genetic inhibition of Tnfa and Tnfr2 in zebrafish results in the mobilization ...
Agrawal Rachana R Department of Medicine, University of Virginia Health System, Allergy Division, PO Box 801355, Charlottesville, VA, 22908-1355, USA, - - 2014
Atopic dermatitis (AD) is a chronic inflammatory skin condition with complex etiology that is dependent upon interactions between the host and the environment. Acute skin lesions exhibit the features of a Th2-driven inflammatory disorder, and many patients are highly atopic. The skin barrier plays key roles in immune surveillance and ...
Bhagwat Sampada S SS Department of Occupational and Environmental Medicine, University Hospital of North Norway, NO- 9038 Tromsø, Norway; Department of Medical Biology, Faculty of Health Sciences, UiT- The Arctic University of Norway, NO- 9037 Tromsø, - - 2014
Occupational skin symptoms are prevalent among the workers of the seafood processing industry. In this study we investigate the role of salmon (Salmo salar) and king crab trypsin (Paralithodes camtschaticus) as inducers of inflammation in skin via secretion of inflammatory mediators. Human skin keratinocytes (HaCaT cells) were exposed to purified ...
Khattri Saakshi S Laboratory for Investigative Dermatology, Rockefeller University, New York, - - 2014
Atopic dermatitis (AD) is the most common inflammatory disease. Evolving disease models link changes in epidermal growth and differentiation to TH2/TH22 cytokine activation. However, these models have not been tested by in vivo suppression of T-cell cytokines. Cyclosporine (CsA) is an immunosuppressant that is highly effective for severe disease, but its ...
Breuer Johanna J Department of Neurology, University of Münster, Münster, - - 2014
Objective: Environmental conditions (e.g. latitude) play a critical role in the susceptibility and severity of many autoimmune disorders, including Multiple Sclerosis (MS). Here, we investigated the mechanisms underlying the beneficial effects of immune regulatory processes induced in the skin by moderate ultraviolet B (UVB) radiation on central nervous system (CNS) ...
Yamaguchi Yukie Y Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Kanagawa, - - 2014
Extracellular matrix (ECM) is not only involved in the maintenance of normal physiological tissue but also in interactions with other ECM components, tissue remodeling, and modulating immune responses. The skin provides a distinctive environment characterized by rich fibroblasts producing various ECM proteins, epithelial-mesenchymal interactions, and immune responses induced by external ...
Hersini Kamelia J KJ Department of Health Science and Technology,, Aalborg University, DK-9220 Aalborg, - - 2014
Skin microdialysis is an established method for in vivo sample collection from the extracellular fluid space. This method has been extensively used in studies of inflammatory reactions in the skin of animals and humans. Microdialysis consists of the implantation of semi-permeable probes into the upper dermis, perfusion with a physiological ...
Czarnowicki Tali T The Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY; Center for Clinical and Translational Science, The Rockefeller University, New York, - - 2014
Atopic dermatitis is the most common chronic inflammatory skin disease. Its pathogenesis combines barrier defects, immune dysregulation, and increased skin infections; however, the relative contribution of each of these components is yet to be determined. Uninvolved atopic dermatitis skin also displays broad immune and barrier abnormalities, which highlights a role ...
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