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Hommes Tijmen J TJ 1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 3Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 4Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
Streptococcus pneumoniae is the most common causative organism in community-acquired pneumonia responsible for millions of deaths every year. DNAX-activating protein of 12 kDa is an adaptor molecule for different myeloid expressed receptors involved in innate immunity. Animal study. University research laboratory. DNAX-activating protein of 12 kDa-deficient (dap12) and wild-type mice. ...
Zhang Li L Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, PR - - 2014
Cathepsin B (CB) is involved in the turnover of proteins and has various roles in maintaining the normal metabolism of cells. In our recent study, CB is increased in the muscles of polymyositis/dermatomyositis (PM/DM). However, the role of CB in interstitial lung disease (ILD) has not been reported. ILD is ...
Srivastava Smita S Departments of Medicine, Microbiology, and Pathology, New York University School of Medicine, New York, NY, - - 2014
Mycobacterium tuberculosis, the bacterium that causes tuberculosis (TB), is an intracellular pathogen of mononuclear phagocytes. Although M. tuberculosis has traditionally been thought to survive and replicate in macrophages, recent work in our laboratory and others has revealed that M. tuberculosis infects multiple subsets of mononuclear phagocytes in vivo and in vitro. In ...
Jazwa Agnieszka A Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, - - 2014
Sarcoidosis is a granulomatous disease of unknown etiology. The disease has an important inflammatory and immune component; however, its immunopathogenesis is not completely understood. Recently, the role of microRNAs (miRNAs), the small non-coding RNAs, has attracted attention as both being involved in pathogenesis and serving as disease markers. Accordingly, changes ...
Richard E A EA Normandie Université, UNICAEN, SF 4206 ICORE/LABÉO Frank Duncombe, 14053, Caen Cedex 4, - - 2014
Multiple cytological patterns occur in bronchoalveolar lavage fluid (BALF) of horses with inflammatory airway disease (IAD). Only few data on BALF cytokine profiles are available for horses with IAD, and are limited to mRNA expression. Cytological profiles of IAD are associated with different BALF immunological pathways. To investigate BALF cytokine ...
Teeguarden Justin G - - 2014
BackgroundToxicity testing the rapidly growing number of nanomaterials requires large scale use of in vitro systems under the presumption that these systems are sufficiently predictive or descriptive of responses in in vivo systems for effective use in hazard ranking. We hypothesized that improved relationships between in vitro and in vivo ...
Sixt S U SU Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, - - 2014
In sarcoidosis, an antigen specific immune response is a putative mechanism, resulting in granulomatous inflammation. Since the proteasome is involved in antigen presentation, alterations in the alveolar and parenchymal proteasomal system may be a feature of sarcoidosis. To explore the role of proteasomes and immunoproteasomes in sarcoidosis. Total proteasome concentration ...
Hao Wenrui W Mathematical Biosciences - - 2014
Lupus nephritis (LN) is an autoimmune disease that occurs when autoantibodies complex with self-antigen and form immune complexes that accumulate in the glomeruli. These immune complexes initiate an inflammatory response resulting in glomerular injury. LN often concomitantly affects the tubulointerstitial compartment of the kidney, leading first to interstitial inflammation and ...
Kawai Toshinao T Department of Human Genetics, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan, - - 2014
Chronic granulomatous disease (CGD) is a primary immunodeficiency disease that is characterized by susceptibility to bacterial and fungal infections. CGD patients also suffer from immune regulatory disorders, such as CGD-associated bowel inflammation with granuloma, which could be caused by excessive inflammation without demonstrable infection. We investigated the clinical manifestation of ...
Verschoor Chris P CP Department of Pathology and Molecular Medicine Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, - - 2014
Pneumonia caused by Streptococcus pneumoniae is a major cause of death and economic burden worldwide. S. pneumoniae is an intermittent colonizer of the human upper respiratory tract and the ability to control asymptomatic colonization determines the likelihood of developing invasive disease. Recognition of S. pneumoniae by resident macrophages via TLR-2 ...
Ding Jie J Wound Healing Research Group, Division of Plastic and Reconstructive Surgery, University of Alberta, Edmonton, Alberta, - - 2014
Effective prevention and treatment of hypertrophic scars (HTS), a dermal form of fibrosis that frequently occurs following thermal injury to deep dermis, is an unsolved significant clinical problem. Previously, we have found that SDF-1/CXCR4 signaling is up-regulated during wound healing in burn patients and HTS tissue after thermal injury. We ...
Mansour Sarah C SC Centre for Microbial Diseases and Immunity Research, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, BC, V6T 1Z4, - - 2014
Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now widely recognized for their multifunctional roles in both the innate and adaptive immune responses. Their diverse immunomodulatory capabilities include the modulation of pro- and anti-inflammatory responses, chemoattraction, enhancement of extracellular and intracellular bacterial killing, cellular differentiation and ...
Le Provost Gabrielle S GS Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, - - 2014
During wound healing, excessive inflammation, angiogenesis and differentiated human dermal fibroblast (HDF) function contribute to scarring, while hyperpigmentation negatively impacts scar quality. Over 100 million patients heal with a scar every year. To investigate the role of the β2-adrenoceptor (β2AR) in wound scarring, the ability of β2AR agonists (β2ARag) to ...
Plikus Maksim V MV Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, 92697, Irvine, CA, - - 2014
Skin wound healing is a complex regenerative phenomenon that can result in hair follicle neogenesis. Skin regeneration requires significant contribution from the immune system and involves substantial remodeling of both epidermal and dermal compartments. In this viewpoint, we consider epigenetic regulation of reepithelialization, dermal restructuring and hair neogenesis. Because little ...
El-Hamoly Tarek T Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Drug Radiation Research Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, Egypt Department of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, - - 2014
Poly(ADP-ribosyl)ation (PARylation) is a protein modification reaction regulating various diverse cellular functions ranging from metabolism, DNA repair, transcription to cell death. We set out to investigate the role of PARylation in wound healing, a highly complex process involving various cellular and humoral factors. We found that topically applied PARP inhibitors ...
Mayet Naeema N Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Parktown, 2193, South - - 2014
Wound healing is a complex and dynamic process that involves the mediation of many initiators effective during the healing process such as cytokines, macrophages and fibroblasts. In addition, the defence mechanism of the body undergoes a step-by-step but continuous process known as the wound healing cascade to ensure optimal healing. ...
Maruyama Yuko Y Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, - - 2014
Purpose: Podoplanin has been shown to be a reliable marker of lymphatic endothelium, but its role in the lymphatic system has not been well investigated. The purpose of this study is to investigate the role of podoplanin in lymphangiogenesis and macrophage functions under inflammatory conditions. Methods: Mouse corneal suture and ...
Strbo Natasa N Department of Microbiology and Immunology, Miller School of Medicine, University of Miami , Miami, - - 2014
Significance: Over the years, it has become clear that, in addition to performing their regular duties in immune defense, the innate and adaptive arms of the immune system are important regulators of the complex series of events that lead to wound healing. Immune cells modulate wound healing by promoting cellular ...
Sivamani Raja K RK Department of Dermatology, University of California-Davis , Sacramento, - - 2014
Significance: Eicosanoids are biologically active lipid mediators derived from arachidonic acid that are important in injury and inflammatory responses. Cyclooxygenase-1 and cyclooxygenase-2 mediate the production of prostanoids, whereas 5-lipoxygenase mediates the production of leukotrienes and hydroxyeicosatetraenoic acids. These lipid mediators have traditionally been known to recruit cells of the immune ...
Pastar Irena I Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine , Miami, - - 2014
Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for restoring the epidermis after injury through a process termed epithelialization. This review will focus on the pivotal role of keratinocytes in epithelialization, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other ...
Ramirez Horacio H Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine , Miami, Florida. ; PIBS Human Genetics and Genomics Program, University of Miami Miller School of Medicine , Miami, - - 2014
Significance: Transforming growth factor β (TGFβ) has a crucial role in maintaining skin homeostasis. TGFβ signaling is important for re-epithelialization, inflammation, angiogenesis, and granulation tissue formation during wound healing. This review will discuss the most important findings regarding the role of TGFβ in epidermal maintenance and its restoration after injury. ...
Barrientos Stephan S Division of Wound Healing and Regenerative Medicine, Department of Surgery, Winthrop University Hospital/ Stony Brook University School of Medicine, Mineola, - - 2014
Wound healing is a complex and dynamic biological process that involves the coordinated efforts of multiple cell types and is executed and regulated by numerous growth factors and cytokines. There has been a drivein the past two decades to study the therapeutic effects of various growth factors in the clinical ...
Cash Jenna L JL School of Physiology & Pharmacology, Medical Sciences, University Walk, Bristol University, Bristol BS8 1TD, UK; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK; Calvin, Phoebe, and Joan Snyder Institute for Infection, Immunity, & Inflammation, University of Calgary, Calgary, AB T2N 4N1, Canada. Electronic address: - - 2014
Disorders of cutaneous repair can cause disability or death given that skin functions as a protective barrier against the external environment. The inflammatory response triggered by tissue damage is thought to play both positive (e.g., pathogen-killing) and negative (e.g., scarring) roles in repair [1-3]. Inflammatory resolution mediators such as chemerin15 ...
Stramer Brian M BM King's College London, Randall Division of Cell and Molecular Biophysics, London SE1 1UL, United Kingdom. Electronic address: - - 2014
Drosophila melanogaster has emerged as a powerful model to understand innate immune responses to infection (note the 2011 Nobel Prize in Physiology or Medicine), and in recent years this system has begun to inform on the role and regulation of immune responses during tissue injury. Due to the speed and ...
Ti Dongdong D Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, - - 2014
Wound healing is a complex and systematic tissue level response to mechanical and chemical injuries that may cause the release of growth factors, cytokines, and chemokines by damaged tissues. For the complex features of these restorative processes, it is a crucial challenge to identify the relevant cell types and biochemical ...
Neuman-Lee Lorin A LA Department of Biology, Utah State University, 3505 Old Main Hill, Logan, UT, 84322, USA, - - 2014
Immune system function is affected by a variety of exogenous and endogenous stressors. Most studies have focused on the effect of stressors on immune function, but not necessarily on trade-offs within the immune system and interactions with energy-mobilizing hormones. In this study, we examined how bactericidal ability and corticosterone interacted ...
Zgheib Carlos C Department of Surgery, Nemours Children's Hospital , Orlando, - - 2014
Significance: Delayed wound healing is one of the most challenging complications of several diseases, including diabetes. There is a vast interest in finding efficient treatments that promote scarless wound healing. The ability of the fetus to regenerate skin wounds after injury has generated much interest in the fetus as a ...
van den Berg Linda M LM Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
Beta-glucans in temporary wound dressings have immuno-stimulatory capacities and have been shown to enhance wound healing in burn patients. Curdlan is a 1,3-linked bacterial/fungal derived beta-glucan that induces inflammatory responses via the C-type lectin receptor dectin-1 on dendritic cells (DCs). Here we investigated the effect of beta-glucan curdlan and the ...
Dachir Shlomit S Department of Pharmacology, Israel Institute for Biological Research , Ness Ziona , Israel - - 2014
Abstract Objective: Macrophages are known to have key functions in almost every stage of wound healing and there is evidence for their beneficial effects in treating decubital ulcers and deep sternal wound infections in human. This study aimed to investigate the efficacy of a treatment with activated macrophages on ameliorating ...
Martin Patricia E PE Department of Life Sciences and Institute for Applied Health Research, Glasgow Caledonian University, Glasgow G4 0BA, UK. Electronic address: - - 2014
Gap junction proteins (connexins) are differentially expressed throughout the multiple layers of the epidermis. A variety of skin conditions arise with aberrant connexin expression or function and suggest that maintaining the epidermal gap junction network has many important roles in preserving epidermal integrity and maintaining homeostasis. Mutations in a number ...
Pellicoro Antonella A The University of Edinburgh/Medical Research Council (MRC) Centre for Inflammation Research, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, - - 2014
Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The interaction of multiple pathways, molecules and systems determines whether fibrosis is self-limiting and homeostatic, or whether it is uncontrolled and excessive. Immune cells have been identified as key players in this fibrotic cascade, with the capacity to ...
Majtan Juraj J Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia; Department of Microbiology, Faculty of Medicine, Slovak Medical University, Bratislava, - - 2014
Honey is a popular natural product that is used in the treatment of burns and a broad spectrum of injuries, in particular chronic wounds. The antibacterial potential of honey has been considered the exclusive criterion for its wound healing properties. The antibacterial activity of honey has recently been fully characterized ...
Haertel Eric E Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, CH 8093 Zurich, - - 2014
The attraction and activation of immune cells is an important response of the skin to injury and allows an efficient defense against invading pathogens. In addition, immune cells fulfill various functions that are important for the repair process. An exaggerated inflammatory response, however, is a hallmark of chronic, non-healing wounds. ...
Martin-Granados Cristina C College of Life Sciences and Medicine, Institute of Medical Sciences, University of Aberdeen , Aberdeen, United Kingdom - - 2014
Significance: Skin wounds cause great distress and are a huge economic burden, particularly with an increasingly aging population that heals poorly. There is an urgent need for better therapies that improve repair. Intracellular signaling pathways that regulate wound repair are activated by growth factors, hormones, and cytokines released at the ...
Terc Joshua J Departments of Physiology & Pharmacology, University of Calgary, 3330 Hospital Dr. NW, Health Sciences Room 1802, Calgary, Alberta, Canada, T2N4N1; Microbiology, Immunology & Infectious Diseases, University of Calgary, 3330 Hospital Dr. NW, Health Sciences Room 1802, Calgary, Alberta, Canada, - - 2014
The intestinal epithelial barrier plays a key role in the maintenance of homeostasis within the gastrointestinal tract. Barrier dysfunction leading to increased epithelial permeability is associated with a number of gastrointestinal disorders including the inflammatory bowel diseases (IBD)- Crohn's disease and ulcerative colitis. It is thought that the increased permeability ...
Enderlin Vaz da Silva Zoé Z Division of Gastroenterology and Hepatology, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, - - 2014
Objective: Macrophages play a critical role in wound repair. However, the specific role of the different macrophage subtypes in wound repair remains incompletely understood. The aim of this study was to compare the wound repair activities of undifferentiated macrophages (M0), classically activated macrophages (M1) and alternatively activated (M2) macrophages. Methods: ...
Crane Meredith J MJ Department of Surgery, Rhode Island Hospital and The Warren Alpert School of Medicine of Brown University, Providence, Rhode Island, United States of - - 2014
The origin of wound repair macrophages is incompletely defined and was examined here in sterile wounds using the subcutaneous polyvinyl alcohol sponge implantation model in mice. Phenotypic analysis identified F4/80(+)Ly6C(hi)CD64(+)MerTK(-) monocytes and F4/80(+)Ly6C(low)CD64(+)MerTK(+) macrophages in the wound. Circulating monocytes were the precursors of inflammatory Ly6C(hi) wound monocytes. Ly6C(low)MerTK(+) macrophages appeared ...
Ernst Matthias M The Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia; Department of Medical Biology, University of Melbourne, Australia. Electronic address: - - 2014
A contiguous intestinal epithelial barrier safeguards against aberrant activation of the immune system and therefore requires molecular mechanisms that ensure effective wound-healing responses. During this processes cytokine-producing myeloid cells serve as rheostats that link the degree of wounding and local inflammation to the epithelial repair response. Likewise, intestinal inflammation is ...
Shi Guo-Bing GB Department of Pharmacy, Shen-yang North Hospital, 83# Wenhua Road, Shen-yang, PR - - 2014
In folklore medicine, Acorus calamus has been used as a wound-healing agent for thousands of years; however, there have been few scientific reports on this activity so far. Now, we explored deeply the wound-healing effect of aqueous extracts from the fresh roots and rhizomes of A. calamus in vivo, as ...
Wang Lihui L Laboratory of Genes and Development, Department of Biochemistry, University of Oxford Oxford, - - 2014
Drosophila has a primitive yet effective blood system with three types of haemocytes which function throughout different developmental stages and environmental stimuli. Haemocytes play essential roles in tissue modeling during embryogenesis and morphogenesis, and also in innate immunity. The open circulatory system of Drosophila makes haemocytes ideal signal mediators to ...
Lee Won-Jae WJ School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul, South Korea. Electronic address: - - 2014
In response to cellular and tissue losses caused by physical or chemical injuries, organisms must activate multiple wound repair systems at the cellular, tissue, and organismal levels. The systemic wound response (SWR) that occurs via interorgan communication between local wound sites and remote organs ensures that the host is protected ...
Tolg Cornelia C London Regional Cancer Program, London Health Sciences Center, Victoria Hospital, London, Ontario, - - 2014
The extracellular matrix polysaccharide hyaluronan (HA) plays a key role in both fibrotic and regenerative tissue repair. Accumulation of high molecular weight HA is typical of regenerative repair, which is associated with minimal inflammation and fibrosis, while fragmentation of HA is typical of postnatal wounds, which heal in the presence ...
Tomblin Victoria V Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New - - 2014
The role of honey in wound healing continues to attract worldwide attention. This study examines the anti-inflammatory effect of four honeys on wound healing, to gauge its efficacy as a treatment option. Isolated phenolics and crude extracts from manuka (Leptospermum scoparium), kanuka (Kunzea ericoides), clover (Trifolium spp.), and a manuka/kanuka ...
Tang Jing J Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Graduate University of Chinese Academy of Sciences, Beijing, - - 2014
Wound-healing represents a major health burden, such as diabetes-induced skin ulcers and burning. Many works are being tried to find ideal clinical wound-healing biomaterials. Especially, small molecules with low cost and function to promote production of endogenous wound healing agents (i.e. transforming growth factor beta, TGF-β) are excellent candidates. In ...
Tornuev Yu V YV Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia, - - 2014
The changes in mammary gland bioimpedance were examined in the dynamics of the inflammatory process. Bioimpedance of affected gland was 2-3-fold lower than that of the contralateral one; normally, this difference did not exceed 10%. The phases of inflammation development were paralleled by changes in bioimpedance. During wound epithelization, impedance ...
Olczyk Pawel P 0000-0001-7387-9587 Department of Community Pharmacy, Medical University of Silesia, ul. Kasztanowa 3, 41-200 Sosnowiec, - - 2014
Wound healing is the physiologic response to tissue trauma proceeding as a complex pathway of biochemical reactions and cellular events, secreted growth factors, and cytokines. Extracellular matrix constituents are essential components of the wound repair phenomenon. Firstly, they create a provisional matrix, providing a structural integrity of matrix during each ...
Heinze Dar M DM Department of Pathology, University of Texas Medical Branch Galveston, TX, - - 2014
Tick salivary glands produce complex cocktails of bioactive molecules that facilitate blood feeding and pathogen transmission by modulating host hemostasis, pain/itch responses, wound healing, and both innate and adaptive immunity. In this study, cutaneous responses at Dermacentor andersoni bite-sites were analyzed using Affymetrix mouse genome arrays and histopathology at 12, ...
Liao James J 0000-0002-6602-8626 Oral Ecology Research Group, Faculty of Dentistry, Laval University, 2420 Rue de la Terrasse, Quebec City, QC, Canada G1V - - 2014
Periodontal diseases, which are inflammatory diseases of bacterial origin affecting the tooth-supporting tissues, are characterized by inflammation and destruction of gingival connective tissue and alveolar bone, and may lead to tooth loss. The aim of the study was to investigate Rokumigan, a Kampo Japanese traditional medicine made of six different ...
Tankersley Amy A Biology Department, University of Central Oklahoma, 100 North University Drive, Edmond, Oklahoma 73034, - - 2014
Chronic wounds such as diabetic foot ulcers, pressure ulcers, and venous leg ulcers contribute to a considerable amount of mortality in the U.S. annually. The inability of these wounds to heal has now been associated with the presence of microbial biofilms. The aim of this study was to determine if ...
Douaiher Jeffrey J Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, - - 2014
Mast cells (MCs) are active participants in blood coagulation and innate and acquired immunity. This review focuses on the development of mouse and human MCs, as well as the involvement of their granule serine proteases in inflammation and the connective tissue remodeling that occurs during the different phases of the ...
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