Search Results
Results 1 - 50 of 764
1 2 3 4 5 6 7 8 9 10 >
Friedrich M M 1] Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany [2] Clinic for Preventive Dentistry and Parodontology, LMU Munich, Munich, - - 2014
Interleukin (IL)-17C is a novel member of the IL-17 cytokine family. Its function in human inflammatory bowel disease (IBD) remains elusive as its role in colonic inflammation is entirely derived from murine models. We aimed to analyze the role of IL-17C in human IBD, focusing on T helper type 17 ...
Veeriah Vimal V Vascular Biology Lab, AU-KBC Research Centre, Anna University, Chennai, India.Department of Biotechnology, Anna University, Chennai, - - 2014
Although Cadmium (Cd) is a well known heavy metal pollutant and teratogen, the mechanism behind Cd mediated teratogenicity remains unknown. Previously we have reported of the protective role of Nitric oxide (NO), a key signaling molecule in the embryonic developmental process, against Thalidomide induced teratogenicity. The objective of this study ...
Zuo Dongmei D Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. - - 2014
Mesenchymal stem cells (MSCs) inhibit the immune response in vitro and prevent the induction of disease in certain experimental models. As a result, MSC‑mediated therapy is a rapidly growing field of research. However, the efficacy of MSCs in the treatment of inflammatory bowel disease (IBD) has remained to be determined. In ...
Ben-Ami Shor Dana D Department of Gastroenterology, Sheba Medical Center affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center affiliated to Sackler Faculty of Medicine, Tel-Aviv University, - - 2014
Improved clinical findings of inflammatory bowel disease (IBD) upon treatment with helminthes and their ova were proven in animal models of IBD and in human clinical studies. The immunomodulatory properties of several helminthes were attributed to the phosphorylcholine (PC) molecule. We assessed the therapeutic potential of tuftsin-PC conjugate (TPC) to ...
Wang Wei W Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. - - 2014
The high risk of developing colorectal carcinoma (CRC), from ulcerative colitis (UC), is well known. Macrophages are widely distributed immune cells that have an indispensable role in UC, as well as in CRC. However, little is currently known about the dynamic changes that occur in macrophage and M1/M2 macrophage subpopulations, during UC‑associated ...
Adachi Teppei T Departments of *Gastroenterology and Hepatology, and †Biochemistry, Kinki University Faculty of Medicine, Osaka-Sayama, Japan; and ‡Center for Innovation in Immunoregulative Technology and Therapeutics, and §Department of Clinical Molecular Biology, Kyoto University Graduate School of Medicine, Kyoto, - - 2014
Expression of heat shock protein A4 (HSPA4, also called Apg-2), a member of the HSP110 family, is induced by several forms of stress. The physiological and pathological functions of HSPA4 in the intestine remain to be elucidated. We assessed HSPA4 expression and function by generating HSPA4-deficient mice and using 214 ...
Matsuoka Katsuyoshi K Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinano-machi, Shinjuku, Tokyo, 160-8582, - - 2014
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gut. Although the precise cause of IBD remains unknown, the most accepted hypothesis of IBD pathogenesis to date is that an aberrant immune response against the gut microbiota is triggered by environmental factors in a genetically susceptible ...
Zhang Dian D a Department of Pathogen Biology and Immunology , Xi'an Medical University , Xi'an , China and Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy , Fourth Military Medical University , Xi'an , - - 2014
Nuclear factor-kappa B (NF-κB) is an important molecule in mediating inflammatory colitis, which can lead to colorectal cancer (CRC). The aim of this study was to evaluate the chemopreventive efficacy of apple polysaccharide extract (AP) in inhibiting NF-κB-mediated inflammation pathways in CRC. We evaluated AP in vitro in HT-29 and ...
Williams Tere M - - 2014
NLR inflammasome formation plays an essential role in modulating immune system homeostasis in the gut. Recently, a caspase-11 non-canonical inflammasome has been characterized and appears to modulate many biological functions that were previously considered to be solely dependent on caspase-1 and the canonical inflammasome. To better elucidate the function of ...
McDermott Andrew J AJ Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, - - 2014
The host response to Clostridium difficile infection in antibiotic-treated mice is characterized by robust recruitment of Gr-1(+) cells, increased expression of inflammatory cytokines including TNFα, and the development of severe epithelial damage. In order to investigate the role of Gr-1(+) cells and TNFα during C. difficile colitis, we treated infected ...
Chen Wei-Xu WX Wei-Xu Chen, Li-Hua Ren, Rui-Hua Shi, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, - - 2014
Ulcerative colitis (UC) is a leading form of inflammatory bowel disease that involves chronic relapsing or progressive inflammation. As a significant proportion of UC patients treated with conventional therapies do not achieve remission, there is a pressing need for the development of more effective therapies. The human gut contains a ...
Roth Sofia S Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, - - 2014
Background/Aims: Anthocyanins are plant-derived dietary components that are highly abundant, for example, in bilberries. We have previously demonstrated that anthocyanins exert anti-inflammatory properties in mouse colitis models and ameliorate disease activity in ulcerative colitis patients. Here, we studied the molecular mechanisms through which anthocyanin-containing bilberry extract (BE) exerts anti-inflammatory effects ...
Sánchez-Fidalgo Susana S Department of Pharmacology, Faculty of Pharmacy, University of Seville, - - 2014
Squalene is a polyunsaturated triterpene which has exhibited anti-cancer and anti-oxidant activities among others. We investigated dietary squalene supplementation effect on an acute colitis model induced by dextran sulfate sodium (DSS) in C57BL/6 mice. Mice were fed from weaning with squalene at 0.02% and 0.1%. After 4 weeks, mice were ...
Alhouayek Mireille M Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Medicinal Chemistry Research Group, - - 2014
N-Palmitoylethanolamine or palmitoylethanolamide (PEA) is an anti-inflammatory compound that was recently shown to exert peroxisome proliferator-activated receptor-α-dependent beneficial effects on colon inflammation. The actions of PEA are terminated following hydrolysis by 2 enzymes: fatty acid amide hydrolase (FAAH), and the less-studied N-acylethanolamine-hydrolyzing acid amidase (NAAA). This study aims to investigate ...
Zeng L X LX Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, - - 2014
β-Arrestins (β-arrs) are regulators and mediators of G protein-coupled receptor signaling, and accumulating evidence suggests that they are functionally involved in inflammation and autoimmune diseases. However, the effect of β-arrs is unclear in inflammatory bowel disease (IBD), and the role of β-arr2 is unknown in ulcerative colitis (UC) and Crohn's ...
Del Carmen Silvina S *Centro de Referencia para Lactobacilos (CERELA-CONICET), San Miguel de Tucumán, Argentina (T4000ILC) †INRA ‡AgroParisTech, UMR Micalis, Jouy-en-Josas, France §Institute of Biological Sciences, Federal University of Minas Gerais (UFMG-ICB), Belo Horizonte, MG, - - 2014
Oral treatment with Lactococcus lactis strains secreting the anti-inflammatory cytokine interleukin (IL)-10 has previously shown success as a therapy for inflammatory bowel diseases (IBD). Our aim was to compare the protective effects of IL-10, delivered by recombinant lactoccoci using 2 novel expression systems, in a murine colitis model mimicking the ...
Um Min Young MY Metabolism and Nutrition Research Group, Korea Food Research Institute , Seongnam, South Korea - - 2014
Abstract Agaricus bisporus (white button mushroom, WBM) is widely consumed in most countries and is reported to have anti-inflammatory and antioxidant activities. However, little is known regarding its effects in dextran sulfate sodium (DSS)-induced colitis, which are related to dysfunction of intestinal immunity. The aim of the present study was ...
Shin Ji-Sun JS Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea; Reactive Oxygen Species Medical Research Center, School of Medicine, Kyung Hee University, Seoul, Republic of Korea; Department of Physiology, School of Medicine, Kyung Hee University, Seoul, Republic of - - 2014
Rubus coreanus Miquel (Rosaceae), the Korean black raspberry, has traditionally been used to treat inflammatory diseases including diarrhea, asthma, stomach ailment, and cancer. Although previous studies showed that the 19α-hydroxyursane-type triterpenoids isolated from Rubus coreanus exerted anti-inflammatory activities, their effects on ulcerative colitis and mode of action have not been ...
Ye Zi Z 1 The First Affiliated Hospital of Chongqing Medical University , Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing, People's Republic of China - - 2014
Interleukin-37 (IL-37) is emerging as an important inhibitor of immune response. This study was set up to investigate the expression of IL-37 in Vogt-Koyanagi-Harada (VKH) disease and to explore its possible regulatory role during inflammation. Twenty-four untreated active VKH patients, 10 VKH patients receiving corticosteroids and cyclosporin A (CsA), and ...
Salem Mohammad M Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, - - 2014
Recognition of bacterial peptidoglycan-derived muramyl-dipeptide (MDP) by nucleotide oligomerization domain 2 (NOD2) induces crucial innate immune responses. Most bacteria carry the N-acetylated form of MDP (A-MDP) in their cell membranes, whereas N-glycolyl MDP (G-MDP) is typical for mycobacteria. Experimental murine studies have reported G-MDP to have a greater NOD2-stimulating capacity ...
Judd Louise M LM MCRI - - 2014
TFF2 is a member of a tripartite family of small proteins, produced by the stomach and the colon. Recombinant TFF2, when applied intra-rectally in a rodent model of hapten colitis, both hastens mucosal healing and reduces inflammatory indices. Additionally, TFF2 is expressed in immune organs, supporting a potential immunomodulatory and ...
Venturini James - - 2014
BackgroundParacoccidioidomycosis (PCM) is systemic mycosis caused by the thermal dimorphic fungus of genus Paracoccidioides, leading to either acute/subacute (AF) or chronic (CF) clinical forms. Numerous CF patients after treatment exhibit sequels, such as pulmonary and adrenal fibrosis. Monocytes are cells that are involved in the inflammatory response during active infection ...
Lin Yan Y Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of - - 2014
Ulcerative colitis (UC) is a major form of inflammatory bowel disease (IBD) and increases the risk of the development of colorectal carcinoma. The anti-inflammatory and immunomodulatory properties of mesenchymal stem cells (MSCs) make them promising tools for treating immune-mediated and inflammatory diseases. However, the lack of robust technique for harvesting ...
Laukens Debby D Department of Gastroenterology, Ghent University, Gent, - - 2014
Ulcerative colitis (UC) is characterized by increased epithelial cell death and subsequent breakdown of the intestinal epithelial barrier, which perpetuates chronic intestinal inflammation. Since fecal bile acid dysmetabolism is associated with UC and tauroursodeoxycholic acid (TUDCA) has been shown to improve murine colitis, we evaluated the effect of TUDCA on ...
Wu Xue-Feng XF State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, - - 2014
Inflammatory bowel disease (IBD) affects millions of people worldwide. Although the etiology of this disease is uncertain, accumulating evidence indicates a key role for the activated mucosal immune system. In the present study, we examined the effects of the natural compound fraxinellone on dextran sulfate sodium (DSS)-induced colitis in mice, ...
Elvington Michelle M Department of Microbiology and Immunology, Children's Research Institute, Medical University of South Carolina, Charleston, SC, - - 2014
The role of complement in IBD has primarily been studied using acute models, and it is unclear how complement affects processes in more relevant chronic models of IBD in which modulation of adaptive immunity and development of fibrosis have pathogenic roles. Using mice deficient in C1q/MBL or C3, we demonstrated ...
Wu Wei W Department of Gastroenterology, The Shanghai Tenth People's Hospital, Tongji University, Shanghai, China Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, - - 2014
Although both innate and adaptive responses to microbiota have been implicated in the pathogenesis of IBD, it is still largely unknown how they are regulated during intestinal inflammation. In this report, we investigated the role of microRNA (miR)-10a, a small, non-coding RNA, in the regulation of innate and adaptive responses ...
Zou Ying Y Department of Traditional Chinese Medicine, The Second Clinical Medical College, Guangdong Medical College, Dongguan, 523808, - - 2014
Baicalin, a flavonoid, has a wide range of pharmacological properties, including immunomodulation. The objective of this study was to investigate the effect of baicalin on the balance of T helper 17 (Th17) and regulatory T (Treg) cells in a colitis model. The rat colitis model was induced by 2,4,6-trinitrobenzene sulfonic ...
Zychowski Katherine E KE College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, TAMU 4458, College Station, TX, 77843-4458, USA, - - 2014
Five million people currently live with Crohn's disease (CD) or ulcerative colitis, the two major forms of inflammatory bowel disease. Available treatments frequently result in side effects that compromise the immune health of the patient. Consequently, alternative therapies that cause fewer systemic effects are needed. Dioctahedral smectite clays have been ...
Cui Li L Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu, Nanjing 210028, PR - - 2014
Baicalin holds a protective effect on inflammatory responses in several diseases. However, its molecular mechanism of anti-inflammatory activity on ulcerative colitis (UC) remains unknown. The present study was conducted to verify whether the anti-inflammation effect of baicalin on experimental colitis is via inhibiting TLR4/NF-κB pathway activation. The inflammatory response in ...
Műzes Györgyi G 2nd Department of Internal Medicine, Semmelweis University, Szentkirályi Street 46, Budapest, 1088, Hungary, - - 2014
Presence of cell-free-circulating DNA (fcDNA) sequences in sera of patients with inflammatory bowel diseases (IBD) is a well-established phenomenon. Potential roles of fcDNA in diagnosis, prognosis and therapy monitoring of chronic inflammatory colonic disorders have already been examined, albeit its actual biological function still remains unclear. In the present experiment, ...
Loera-Arias María J MJ Departamento de Histología, Facultad de Medicina, Universidad Autónoma de Nuevo León (UANL), Madero y Aguirre Pequeño s/n Mitras Centro, 66460, Monterrey, Nuevo León, Mexico, - - 2014
Interleukin-22 (IL-22) participates in the modulation of innate immunity and inflammation. This cytokine has important therapeutic potential, such as with ulcerative colitis, liver and lung injury, and infection, in different animal models. We generated a Lactococcus lactis strain that secretes human IL-22 under the regulation of the nisin-inducible promoter. Identification ...
Landy Jonathan J *Department of Gastroenterology, St Mark's Hospital, London, United Kingdom; †Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark's Campus, London, United Kingdom; ‡Department of Gastroenterology, The Rayne Institute, St Thomas' Hospital, London, United Kingdom; and §Department of Surgery, St Mark's Hospital, London, United - - 2014
Tight junction proteins (TJPs) and dendritic cells (DC) are critical in the pathogenesis of inflammatory bowel diseases. The ileal pouch formed by restorative proctocolectomy provides a unique human model for studying the pathogenesis of inflammatory bowel diseases. Data implicate the microbiota in the pathogenesis of pouchitis, while the role of ...
Wang Shubei S Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, - - 2014
Crohn's disease is a chronic inflammatory bowel disease. Oridonin is an effective component isolated from Rabdosia rubescens. It can inhibit the activation of transcription factor nuclear factor-kappa B and suppress the over expression of cytokines. We postulated that oridonin may be a potential therapeutic candidate for Crohn's disease. To confirm ...
Bates J M JM Department of Pathology, Genetech, South San Francisco, California, - - 2014
Dendritic cells (DCs) form an extensive network in the intestinal lamina propria, which orchestrates the mucosal immune response. Alterations in DC function can predispose to inflammatory bowel disease, although by unknown mechanisms. We show that CD83, a highly regulated DC cell surface protein, modulates the immune response to prevent colitis. ...
Tang Ruihan R *Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; †Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, China; and ‡Department of Immunology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, - - 2014
Inflammatory bowel disease (IBD) is characterized by a damaged intestinal epithelium barrier. Interferon regulatory factor 1 (IRF1) and osteopontin (OPN) regulate cell survival and growth in a variety of circumstances but their effects on the intestinal epithelium have not been elucidated. In this study, we sought to determine the effects ...
Kaushal Naveen N Center for Molecular Immunology and Infectious Disease and Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA - - 2014
Inflammation is a hallmark of inflammatory bowel disease (IBD) that involves macrophages. Given the inverse link between selenium (Se) status and IBD-induced inflammation, our objective was to demonstrate that selenoproteins in macrophages were essential to suppress proinflammatory mediators, in part, by the modulation of arachidonic acid metabolism. Acute colitis was ...
Sakurai Toshiharu T Gastroenterology and Hepatology, Kinki University - - 2014
Colitis-associated cancer (CAC) is caused by chronic intestinal inflammation and reported to be associated with refractory inflammatory bowel disease (IBD). Defective apoptosis of inflammatory cell populations seems to be a relevant pathogenetic mechanism in refractory IBD. We assessed the involvement of stress response protein cold-inducible RNA-binding protein (Cirp) in the ...
Chen Yunzi Y *Laboratory of Metabolic Disease Research and Drug Development, China Medical University, Shenyang, Liaoning, China; †Division of Biological Sciences, Department of Medicine, The University of Chicago, Chicago, Illinois; and ‡Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China. Dr Chen is now with the Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, - - 2014
We recently reported that the gut epithelial vitamin D receptor (VDR) signaling inhibits colitis through inhibition of intestinal epithelial cell apoptosis, and the level of colonic epithelial VDR is markedly reduced in patients with inflammatory bowel diseases (IBD). VDR downregulation promotes colitis, but the mechanism underlying VDR downregulation in IBD ...
Yamamoto Motohisa M Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine , Sapporo , - - 2014
IgG4-related disease (IgG4-RD) is a new disease entity characterized by type 2 helper T (Th2)-dominant inflammation and progressive fibrosis. We found the infiltration of strange cell populations in the fibrotic lesions of submandibular gland specimens obtained from 15 patients with IgG4-RD. These cells expressed CCAAT/enhancer binding protein a (C/EBPα). Many ...
Sacco Rodolfo R Department of Gastroenterology-Pisa University Hospital, Pisa, - - 2014
Cytokines such as TNF-α have a validated role in the immunopathogensis of ulcerative colitis (UC), and intercepting inflammatory cytokines is currently the best option for maximizing treatment efficacy. One of the major sources of inflammatory cytokines are myeloid linage leucocytes (granulocytes, monocytes), which are present in great numbers in the ...
Steiner Stefanie S Medical Clinic 1, Kussmaul Research Campus, Friedrich-Alexander University of Erlangen-Nuremberg, Hartmannstr. 14, 91052, Erlangen, - - 2014
Crohn's disease (CD) and ulcerative colitis (UC) are the two major forms of inflammatory bowel diseases (IBD), which are defined as relapsing inflammations of the gastrointestinal tract. Cyclosporine A (CsA) is a potential rescue treatment to avoid colectomy in severe steroid-refractory UC patients. The molecular mechanism of action of CsA ...
Schneditz Georg G Institute of Molecular Biosciences, University of Graz, 8010 Graz, - - 2014
Antibiotic therapy disrupts the human intestinal microbiota. In some patients rapid overgrowth of the enteric bacterium Klebsiella oxytoca results in antibiotic-associated hemorrhagic colitis (AAHC). We isolated and identified a toxin produced by K. oxytoca as the pyrrolobenzodiazepine tilivalline and demonstrated its causative action in the pathogenesis of colitis in an ...
Setia Shruti S Department of Biophysics, Panjab University, Chandigarh, - - 2014
Uncontrolled cell proliferation and suppressed apoptosis are the critical events transforming a normal cell to a cancerous one wherein the inflammatory microenvironment supports this oncogenic transformation. The process of colon carcinogenesis may be aggravated in chronic inflammatory conditions such as ulcerative colitis where non-steroidal anti-inflammatory drugs (NSAIDs) may effectively prevent ...
Isidro Raymond A RA Department of Physiology and Pharmacology, Ponce School of Medicine and Health Sciences, Ponce, PR 00716, - - 2014
Patients with Inflammatory Bowel Disease (IBD), most commonly Crohn's disease (CD) or ulcerative colitis (UC), suffer from chronic intestinal inflammation of unknown etiology. Increased proinflammatory macrophages (M1) have been documented in tissue from patients with CD. Anti-inflammatory macrophages (M2) may play a role in UC given the preponderance of Th2 ...
Du Chao C 1] Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China [2] Department of Gastroenterology, Linyi People's Hospital, Linyi, Shandong, 276000, PR - - 2014
Inflammatory macrophages in colonic mucosa are the leading drivers of the pathology associated with inflammatory bowel disease (IBD). Here we examined whether gadolinium chloride (GdCl3), a macrophage selective inhibitor, would improve the course of 2,4,6-trinitro benzene sulfonic acid (TNBS) and dextran sodium sulfate (DSS)-induced colitis in mice and the potential ...
Li Li L 1] College of Life Sciences, Shenzhen Key Laboratory of Microbial Genetic Engineering, Shenzhen University, Shenzhen 518060, China - - 2014
Edible berries have a broad spectrum of biomedical functions, including improving immune responses and reducing risk for chronic diseases. In this study, the anti-inflammatory activities of crude extracts (CEs), anthocyanin-rich fractions (ARFs), and des-anthocyanin fractions (DAFs) from seven berries were evaluated based on their inhibitory effects on nitric oxide (NO) ...
Li Yanmei Y Department of Gastroenterology, Qilu Hospital, Shandong University, 107 Wenhua West Road, Jinan 250012, - - 2014
Interleukin- (IL-) 35 and IL-37 are newly discovered immune-suppressing cytokines. They have been described in inflammatory diseases such as collagen-induced arthritis and asthma. However, their expressions in inflammatory bowel disease (IBD) patients have not been yet explored. Our aim was to evaluate serum and inflamed mucosal levels in IBD patients. ...
Sartor R Balfour RB Division of Gastroenterology and Hepatology, Center for Gastrointestinal Biology and Disease, Department of Medicine, Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, - - 2014
Abundant clinical and experimental evidence supports a role for resident microbiota in Crohn's disease and pouchitis, and probably in ulcerative colitis (UC). These disorders occur in areas of highest bacterial concentrations. Pouchitis and Crohn's colitis respond to antibiotics, while pouchitis and UC can be treated with probiotics. Serologic markers recognizing ...
Mouzaoui Souad S Institut National de la Santé et de la Recherche Médicale U1149, Equipes de Recherches Labellisées CNRS, Centre de Recherche sur l'Inflammation, 75018 Paris, France ; Faculté des Sciences Biologiques, Laboratoire de Biologie Cellulaire et Moléculaire, Université des Sciences et de la Technologie Houari Boumediene, 16111 Algiers, - - 2014
Reactive oxygen species- (ROS-) mediated injury has been implicated in several inflammatory disorders, including inflammatory bowel disease (IBD). NADPH oxidases (NOXs) are the major source of endogenous ROS. Here, we investigated the role of NOXs derived-ROS in a mouse model of colitis induced by the proinflammatory cytokine, tumor necrosis factor-α ...
1 2 3 4 5 6 7 8 9 10 >