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Nahar Pragati P PP Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island, - - 2014
Abstract Inflammation and the presence of pro-inflammatory cytokines are associated with numerous chronic diseases such as type-2 diabetes mellitus, cardiovascular disease, Alzheimer's disease, and cancer. An overwhelming amount of data indicates that curcumin, a polyphenol obtained from the Indian spice turmeric, Curcuma longa, is a potential chemopreventive agent for treating ...
Zhou Rui - - 2014
Alginate has notably diverse pharmacological activities. In the present study, we investigated the anti-inflammatory activity of the guluronate oligosaccharides prepared by oxidative degradation (GOS-OD) from alginate. We found that GOS-OD significantly attenuated the production of nitric oxide (NO), prostaglandin E2 (PGE2) and reactive oxygen species (ROS), the expression of inducible ...
Ozer J J Dept. of Microbiology, Immunology and Genetics, Faculty of Health Sciences Ben-Gurion University of the Negev, Beer Sheva, Israel. Electronic address: - - 2014
Various plant organs of Nuphar lutea (L.) SM. (Nymphaeaceae) are used in traditional medicine for the treatment of arthritis, fever, aches, pains and inflammation. The main purpose of this study was to determine the anti-inflammatory effect of Nuphar lutea leaf extract (NUP) in two septic shock models: 1. Survival of ...
Xu Chang-Peng CP Guangzhou Institute of Traumatic Surgery, The Fourth Affiliated Hospital of Medical College, Jinan University, Guangzhou, Guangdong, People's Republic of China; Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of - - 2014
TNF-α, one of the most potent pro-inflammatory cytokines, plays a critical role in inhibition of osteoblast differentiation and bone regeneration in persistent inflammatory microenvironment. To explore the mechanism, quantitative proteomics based on iTRAQ and MRM were employed. The results showed 6 proteins involved in BMP-2 induced osteoblast differentiation inhibition by ...
De Paepe Boel B Department of Neurology, Myopathology & Neuromuscular Reference Centre, Ghent University Hospital, Belgium. Electronic address: - - 2014
Evidence accumulates implicating interferons (IFNs) in the chronic inflammation associated with the idiopathic inflammatory mypathies (IM). Dermatomyositis in particular appears to display a strong IFN type 1 signature. Proposed pathogenic actions of IFNs include the upregulation of major histocompatibility complex class I on muscle fibres, and the induction of a ...
Mahanta Anusree A Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, Tezpur, Assam, - - 2014
Dysregulation of the cytokine network in severe malaria owing to variations in factors like parasite load, strains and host factors is well documented but the key cytokines that are dysregulated remain poorly elucidated. Longitudinal changes in cytokine levels in an individual with parasitemia and disease resolution is likely to identify ...
Savic Danijela D Department for Neurobiology, Institute for Biological Research "Sinisa Stankovic", University of Belgrade , Belgrade, Republic of Serbia - - 2014
Abstract Ribavirin (RBV) is synthetic purine nucleoside analogue, licensed as anti-viral drug that displays immunomodulatory actions on various immune cells. Our previous ex vivo studies have demonstrated immunosuppressive effects of RBV on reactive T-lymphocytes in experimental autoimmune encephalomyelitis. Here, we examined the effects of RBV on inflammatory response of microglia. ...
Eilers June J College of Nursing, University of Nebraska Medical Center College of Nursing, - - 2014
Mucositis is an inflammatory process that can involve the mucosal epithelial cells from the mouth to the rectum. Historically, mucositis and stomatitis were used interchangeably, but momentum has increased toward more specific terminology since the 2000s. Stomatitis refers to inflammatory diseases of the mouth, including the mucosa, dentition, periapices, and ...
Nisar Albeena A Department of Biochemistry, University of Kashmir, Srinagar-190006, J&K, - - 2014
Atropa acuminata has been widely used in traditional medicine against arthritis and several associated inflammatory disorders. The present study was undertaken to investigate the anti-arthritic activities of ethanolic extract of Atropa accuminata (AAEE) and to explore the probable mechanism of action. The anti-arthritic activity of AAEE was evaluated within a ...
Lim Dahae D Department of Korean Physiology, College of Pharmacy, Kyung Hee University, Seoul, Republic of - - 2014
Stemona tuberosa (ST) is a traditional herbal medicine used for the treatment of various respiratory diseases in eastern Asia. We investigated the anti-inflammatory effects of a ST water extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and in cigarette smoke (CS)-induced lung inflammation mouse models. RAW 264.7 macrophages were treated with ...
Moran E M EM Institute for Immunology and Infectious Diseases (IIID), Murdoch University, Murdoch, WA, - - 2014
The idiopathic inflammatory myopathies are a heterogeneous group of disorders characterised by diffuse muscle weakness and inflammation. A common immunopathogenic mechanism is the cytokine-driven infiltration of immune cells into the muscle tissue. Recent studies have further dissected the inflammatory cell types and associated cytokines involved in the immune-mediated myopathies and ...
Wang Yimin Y Department of Stomatology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, 350025, Fujian Province, People's Republic of - - 2014
Protocatechuic acid (PCA), a major metabolite of anthocyanins, has been shown to have antioxidant, antitumoral, and anti-inflammatory activities. In this study, we investigated the anti-inflammatory effects of PCA on lipopolysaccharide (LPS)-induced inflammatory response in human gingival fibroblasts (HGFs). The effects of PCA on LPS-induced inflammatory cytokines IL-6 and chemokines IL-8 ...
Zhang Yang Y Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 32500, Zhejiang, - - 2014
Biochanin A, one of the major isoflavonoids in red clover or cabbage, has been reported to have anti-inflammatory effects. However, the molecular mechanism underlying the anti-inflammatory effects of biochanin A has not been completely elucidated. The aim of this study was to investigate the anti-inflammatory effect and mechanism on lipopolysaccharide ...
Pijanowski L L Department of Evolutionary Immunology, Jagiellonian University, Gronostajowa 9, PL30-387, Krakow, - - 2014
Neutrophilic granulocytes and macrophages are crucial for the innate immune response against infections. They migrate into the focus of inflammation, where they efficiently bind, engulf and kill bacteria by proteolytic enzymes, antimicrobial peptides, reactive oxygen (ROS) and nitrogen (RNS) species. Moreover, activated neutrophils and macrophages can form extracellular traps (ETs). ...
Lee Jung-Hoon JH Department of Biotechnology and Bioinformatics, Korea University, Sejong, 339-700, Republic of - - 2014
The proinflammatory cytokine interleukin-1β plays an important role in protecting the host against airway infection; however, it can also trigger a massive influx of neutrophils into the airways, causing tissue damage. Anti-inflammatory treatments are particularly in demand for patients suffering from chronic inflammatory diseases. Sophora flavescens is a traditional herbal ...
Wang Mengting M a Medical Faculty , Kunming University of Science and Technology , Kunming , P.R. - - 2014
The aim of this paper is to summarise the blocking effects of parthenolide on the cytokines and pathways that cause inflammation. Analyses of the chemical structure of parthenolide have tried to identify the active domains that play key roles in its anti-inflammatory activity. This review focuses on the anti-inflammatory actions ...
Yu Zheng-Miao ZM Department of Cerebropathia, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China, - - 2014
To explore the pharmacological anti-inflammatory mechanism of Chinese formula Qingwen Baidu Decoction (, QBD) from the view of holistic biology. The rats were randomly divided into a normal conrol group, a lipopolysaccharide (LPS) group, the low- and high-dose QBD groups, and a dexamethasone (DXM) group. NR8383 cells were treated with ...
Dohnert Marcelo B MB Laboratório de Síntese de Complexos Multifuncionais, Programa de Pós-Graduação em Ciências e Engenharia de Materiais, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105 Universitário, P.O. Box 3167, 88806-000, Criciúma, Santa Catarina, - - 2014
Tendinitis is a painful condition that occurs in tendons in response to repetitive use or direct trauma. The therapeutic approaches commonly employed to modulate inflammation have not achieved complete success in chronic cases of tendinitis. In this scenario, considering the anti-inflammatory properties of pulsed therapeutic ultrasound and gold nanoparticles (GNPs), ...
Wang Lijun L Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Food and Nutritional Sciences Programme, School of Life Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, - - 2014
Neutral polysaccharides are one of the active components in the American ginseng roots. Recently, the studies about American ginseng polysaccharides are mainly centered on acidic polysaccharides, while there is relatively limited research that explores neutral polysaccharides. In this study a novel neutral polysaccharide (PPQN) was isolated from American ginseng roots ...
Impellizzeri Daniela D Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 31-98166 Messina, - - 2014
The beneficial properties of the flavonoid fraction of bergamot juice (BJe) have been raising interest and have been the subject of recent studies, considering the potentiality of its health promoting substances. Flavonoids have demonstrated radical-scavenging and anti-inflammatory activities. The aim of the present study was to examine the effects of ...
Silveira Marcia L L ML Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CP 19046, 81531-980 Curitiba, PR, Brazil; Universidade da Região de Joinville, CEP 89219-710 Joinville, SC, - - 2014
Glucans comprise an important class of polysaccharides present in basidiomycetes with potential biological activities. A (1→3)-β-d-glucan was isolated from Pleurotus sajor-caju via extraction with hot water followed by fractionation by freeze-thawing and finally by dimethyl sulfoxide extraction. The purified polysaccharide showed a (13)C-NMR spectrum with six signals consisting of a ...
Voltolini Chiara C Department of Molecular and Developmental Medicine, University of Siena, Siena - - 2014
The purpose of the study was to investigate Ucn2 involvement in placental and myometrial inflammatory pathways associated with parturition by evaluating: i) Ucn2 and its receptor, CRH-R2, expression in laboring/non laboring human gestational tissues and in mouse utero-placental tissues approaching delivery; ii) Ucn2 effect on myometrial contractility and on the ...
Rao R R Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC - - 2014
The superantigen Staphylococcal enterotoxin B (SEB) is a potent activator of Vβ8+T-cells which results in the clonal expansion of ∼30% of the T-cell pool. Consequently, this leads to the substantial release of inflammatory cytokines, induction of toxic shock, and eventually death. In the current study, we investigated if Δ9Tetrahydrocannabinol (THC), ...
Abokwidir Manal M Department of Dermatology, Wake Forest School of Medicine; Winston-Salem, North - - 2014
Abstract Ivermectin shows broad-spectrum anti-parasitic activity. It kills the Demodex mites that reside in the pilosebaceous units of patients with papulopustular rosacea. Ivermectin also has anti-inflammatory effects, it decreases cellular and humoral immune responses. Inflammatory mechanisms appear to play a dominant role in development of rosacea inflammatory lesions. Additionally, there ...
Králová A A Laboratory for Atherosclerosis Research, Centre of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. - - 2014
Atherosclerosis is a degenerative inflammatory disease of the vascular wall, which is characterized by the formation of atherosclerotic plaques that contain lipids, activated smooth muscle cells, immune cells, foam cells, a necrotic core and calcified sites. In atherosclerosis pathology, monocytes and macrophages play the most important role by accumulating redundant ...
Kwon Hyokjoon H Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY 10461, - - 2014
Adipose tissue inflammation is one pathway shown to mediate insulin resistance in obese humans and rodents. Obesity induces dynamic cellular changes in adipose tissue to increase proinflammatory cytokines and diminish anti-inflammatory cytokines. However, we have found that anti-inflammatory interleukin-13 (IL-13) is unexpectedly induced in adipose tissue of obese humans and ...
Mobraten Kaia K Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences , Ås , Norway - - 2014
Abstract Introduction: Bile acids are recognized as signaling molecules, mediating their effects both through the cell surface receptor TGR5 and the nuclear receptor FXR. After a meal, approximately 95% of the bile acids are transported from terminal ileum and back to the liver via the portal vein, resulting in postprandial ...
Ildefonso Cristhian J CJ University of Florida College of Medicine, Molecular Genetics & Microbiology , 1600 SW Archer Rd PO Box 100266-MGM , Gainesville, Florida, United States , 32610-0266 , 352-273-5083 ; - - 2014
Inflammation of the retina is a contributing factor in ocular diseases such as uveitis, diabetic retinopathy, and age related macular degeneration (AMD). The M013 immunomodulatory protein from myxoma virus has been shown to interfere with the pro-inflammatory signaling pathways involving both the NLRP3 inflammasome and NF-κB. We have developed and ...
Yu Wen-Wen - - 2014
Uncontrolled inflammatory responses cause tissue injury and severe immunopathology. Pharmacological interference of intracellular proinflammatory signaling may confer a therapeutic benefit under these conditions. Daphnetin, a natural coumarin derivative, has been used to treat inflammatory diseases including bronchitis. However, the therapeutic effect of daphnetin in inflammatory airway disorders has yet to ...
Chung Sangwoon S Division of Pulmonary, Allergy, Critical Care, and Sleep, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, - - 2014
Macrophages are a heterogeneous population of immune cells that are essential for the initiation and containment inflammation. There are 2 well-established populations of inflammatory macrophages: classically activated M1 and alternatively activated M2 macrophages. The FoxO family of transcription factors plays key roles in a number of cellular processes, including cell ...
Yuan Yun - - 2014
BackgroundIn response to cerebral ischemia, activated microglia release excessive inflammatory mediators which contribute to neuronal damage. Therefore, inhibition of microglial over-activation could be a therapeutic strategy to alleviate various microglia-mediated neuroinflammation. This study was aimed to elucidate the anti-inflammatory effects of Scutellarin and Edaravone given either singly, or in combination ...
Yuan Xiao X Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Road, Wuhan, 430030, - - 2014
NO and NO synthase (NOS) are known to play key roles in the development of myocardial apoptosis induced by ischemia/hypoxia. Current evidence suggests that angiotensin II type 1 receptor blockers, such as telmisartan, lower blood pressure and produce beneficial regulatory effects on NO and NOS. Here, we examined the protective ...
Hoegenauer Klemens - - 2014
GPBAR1 (also known as TGR5) is a G protein-coupled receptor (GPCR), which triggers intracellular signals upon ligation by various bile acids. The receptor has been studied mainly for its function in energy expenditure and glucose homeostasis, and there is little information on the role of GPBAR1 in the context of ...
Yu Pin P Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing, 100021, China, - - 2014
In previous studies of hand, foot, and mouth disease patients fatally infected with enterovirus 71 (EV71), the distribution of viral protein, but not the genome, was determined. To understand the pathogenesis of EV71, however, it is important to investigate the spread of the viral genome. There have been no pathological ...
Lin Sue-Jane - - 2014
BackgroundHighly pathogenic influenza viruses cause high levels of morbidity, including excessive infiltration of leukocytes into the lungs, high viral loads and a cytokine storm. However, the details of how these pathological features unfold in severe influenza infections remain unclear. Accumulation of Gr1¿+¿CD11b¿+¿myeloid cells has been observed in highly pathogenic influenza ...
Tan Zheng Z UAB, United - - 2014
There has been fast growing evidence showing that glycolysis plays a critical role in the activation of immune cells. Enhanced glycolysis leads to increased formation of intracellular lactate that is exported to the extracellular environment by monocarboxylate transporter 4 (MCT4). Although the biological activities of extracellular lactate have been well ...
Bukrinsky Michael M George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA. Electronic address: - - 2014
Extracellular cyclophilins (eCyPs) are pro-inflammatory factors implicated in pathogenesis of a number of inflammatory diseases. Most pathogenic activities of eCyPs are related to their chemotactic action towards leukocytes, which is mediated by eCyP receptor on target cells, CD147, and involves peptidyl-prolyl cis-trans isomerase activity of cyclophilins. This activity is inhibited ...
Katsuyama Eri E Keui University, - - 2014
Formation of foreign body giant cells (FBGCs) occurs following implantation of medical devices such as artificial joints and is implicated in implant failure associated with inflammation or microbial infection. Two major macrophage subpopulations, M1 and M2, play different roles in inflammation and wound-healing, respectively. Therefore, M1/M2 polarization is crucial for ...
Zhang Ting T Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: - - 2014
Carbon nanotubes (CNTs) are widely used in industry and biomedicine. While several studies have focused on biological matters, attempts to systematically elucidate the toxicity mechanisms of CNTs are limited. The aim of the present study was to evaluate and compare the cytotoxicity of raw multi-walled carbon nanotubes (MWCNTs) and MWCNTs ...
Na Ha-Na HN Department of Infection and Obesity, Pennington Biomedical Research Center, Baton Rouge, - - 2014
Aging and obesity are associated with elevated pro-inflammatory cytokines such as monocyte chemoattractant protein (MCP)-1 and tumor necrosis factor (TNF)α, which are linked to insulin resistance. Anti-inflammatory agents have marginal effect in improving insulin resistance. Hence, agents are needed to improve glycemic control despite the inflammation. Ad36, a human adenovirus, ...
Zoccal Karina Furlani KF Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Brazil. Electronic address: - - 2014
Tityus serrulatus venom (TsV) consists of numerous peptides with different physiological and pharmacological activities. Studies have shown that scorpion venom increases pro-inflammatory cytokine production, contributing to immunological imbalance, multiple organ dysfunction, and patient death. We have previously demonstrated that TsV is a venom-associated molecular pattern (VAMP) recognized by TLRs inducing ...
Choi Eun-Young EY Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Republic of - - 2014
Here we aimed to investigate the anti-inflammatory effects of calcium citrate in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The anti-inflammatory effects of calcium citrate were investigated by assessing pro-inflammatory factors (NO, ROS, NF-κB, iNOS, and COX-2) and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). Treatment of cells with calcium citrate (10-100μM) significantly ...
Hye Yang Ji J College of Pharmacy, Chosun University, Gwangju 501-759, - - 2014
Sestrins (Sesns) are conserved antioxidant proteins that accumulate in cells in response to various stresses. However, the regulatory roles of Sesn2 in the immune system and in inflammatory response remain obscure. In the present study, we investigated whether Sesn2 regulates Toll like receptor (TLR)-mediated inflammatory signaling and sought to identify ...
Li Yan Y Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19014, - - 2014
Identifying signaling pathways that regulate hematopoietic stem and progenitor cell (HSPC) formation in the embryo will guide efforts to produce and expand HSPCs ex vivo. Here we show that sterile tonic inflammatory signaling regulates embryonic HSPC formation. Expression profiling of progenitors with lymphoid potential and hematopoietic stem cells (HSCs) from ...
van Stijn Caroline M W CM Division of Endocrinology, Diabetes & Hypertension - - 2014
Adiponectin (APN), a pleiotropic adipokine that exerts anti-inflammatory, antidiabetic, and antiatherogenic effects through its receptors (AdipoRs), AdipoR1 and AdipoR2, is an important therapeutic target. Factors regulating AdipoR expression in monocyte/macrophages are poorly understood, and the significance of polarized macrophage activation in controlling AdipoR expression and the APN-mediated inflammatory response has ...
Alamili Mahdi M Department of Surgery, Køge Hospital, University of Copenhagen, Køge, Denmark - - 2014
Background: Endotoxaemia is widely used as an experimental model to study sepsis under controlled conditions. Nighttime endotoxaemia induces a more pronounced inflammatory stress response compared to daytime. Previously, we have shown that melatonin has antioxidative and anti-inflammatory effects in inflammatory response to daytime endotoxaemia. Herein, we examined the effect of ...
Boyanapalli Sarandeep S S - - 2014
The role of phytochemicals in preventive and therapeutic medicine is a major area of scientific research. Several studies have illustrated the mechanistic roles of phytochemicals in Nrf2 transcriptional activation. The present study aims to examine the importance of the transcription factor Nrf2 by treating peritoneal macrophages from Nrf2 (+/+) and ...
Cohen Merav M Department of Neurobiology, Weizmann Institute of Science, Rehovot, - - 2014
Tissue microenvironment influences the function of resident and infiltrating myeloid-derived cells. In the central nervous system (CNS), resident microglia and freshly recruited infiltrating monocyte-derived macrophages (mo-MΦ) display distinct activities under pathological conditions, yet little is known about the microenvironment-derived molecular mechanism that regulates these differences. Here, we demonstrate that long ...
Yang Hsin-Ling HL Institute of Nutrition, China Medical University, Taichung 40402, - - 2014
Antrodia salmonea (AS), a well-known medicinal mushroom in Taiwan, has been reported to exhibit anti-oxidant, anti-angiogenic, anti-atherogenic, and anti-inflammatory effects. In the present study, we investigated the activation of Nrf2-mediated antioxidant genes in RAW264.7 macrophages by the fermented culture broth of AS, studied the resulting protection against lipopolysaccharide (LPS)-stimulated inflammation, ...
Niu Xiaofeng X School of Pharmacy, Xi'an Jiaotong University, No. 76 Western Yanta Road, Xi'an City, Shaanxi Province, 710061, People's Republic of China, - - 2014
Cavidine is an isoquinoline alkaloid which is isolated from Corydalis impatiens. In traditional Tibetan herb, C. impatiens has been widely used for treatment of skin injuries, hepatitis, cholecystitis, and scabies. The present study aimed to evaluate its anti-inflammatory effect and investigate the mechanisms underlying this anti-inflammatory action. We used different ...
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