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Zhang W W Department of Immunology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, - - 2014
Serine/threonine kinase family members p21-activated kinases (PAKs) are important regulators of cytoskeletal remodeling and cell motility in mononuclear phagocytic system, but their role in macrophage differentiation and polarization remains obscure. We have shown here that inflammatory stimuli induced PAK1 overexpression in human and murine macrophages. Elevated expression of PAK1 contributed ...
OʼShea Nuala R NR *Division of Medicine, University College London, London, United Kingdom; †Department of Gastroenterology, University College London Hospital, London, United Kingdom; and ‡Department of Microbial Diseases, Eastman Dental Institute, University College London, London, United - - 2014
: There has been an explosion of literature in recent years highlighting the pivotal role of matrix metalloproteases (MMPs) in the immune response. This review will focus on our current understanding of MMPs in the gastrointestinal tract and in particular the field of inflammatory bowel disease. MMPs are structurally similar ...
Dhande Isha I 1] Department of Pharmacological and Pharmaceutical Sciences, Heart and Kidney Institute, University of Houston, Houston, TX, USA [2] Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn University, Auburn, AL, - - 2014
Macrophages have an important role in the pathogenesis of hypertension and associated end-organ damage via the activation of the Toll-like receptors, such as Toll-like receptor-4 (TLR4). Accumulating evidence suggests that the angiotensin AT2 receptor (AT2R) has a protective role in pathological conditions involving inflammation and tissue injury. We have recently ...
Köffel René R Institute of Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, - - 2014
During inflammation, neutrophils are rapidly mobilized from the bone marrow storage pool into peripheral blood to subsequently enter lesional sites where most of them rapidly undergo apoptosis. Monocytes constitute a second wave of inflammatory immigrates giving rise to long-lived macrophages and dendritic cell subsets. According to descriptive immunophenotypic and cell ...
Neacsu Patricia P University of Bucharest, Department of Biochemistry and Molecular Biology, 91-95 Spl. Independentei, 050095, Bucharest, - - 2014
Macrophages play a pivotal role in the hosts response to biomaterials being considered as an essential cell type during both optimal tissue-implant integration and pathologic process of implant failure. Hence, understanding of their cellular activity on biomaterials is important for improving evaluation and design of biomaterials for biomedical applications. In ...
Stephens W Zac WZ Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84211, - - 2014
Resident microbes within the gastrointestinal tract are known to influence the progression of inflammatory bowel diseases (IBD); however, the identity of the bacteria that exacerbate inflammation remains unknown. In the most recent issue of Cell, Palm et al. (2014) utilize the host immune response as a way to identify colitogenic bacteria.
Go Dewi P DP Particulate Fluids Processing Centre, Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, 3010, Victoria, Australia; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, 3010, Victoria, - - 2014
Tissue engineering is a complex and dynamic process that requires varied biomolecular cues to promote optimal tissue growth. Consequently, the development of delivery systems capable of sequestering more than one biomolecule with controllable release profiles is a key step in the advancement of this field. This study develops multilayered polyelectrolyte ...
Schilling Tom - - 2014
Ion channels play pivotal roles in regulating important functions of macrophages, such as cytokine and chemokine production, migration, proliferation, phagocytosis and others. In this study, we have identified a novel ion channel type in macrophages, namely transient receptor potential M7 (TRPM7) channels. TRPM7 channel activity is differentially regulated in macrophages, ...
Wright Kyle T KT Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA University of Connecticut Heath Center- MC3710 263 Farmington Avenue, Farmington, CT 06030. Electronic address: - - 2014
Inflammatory responses can vary depending on a myriad of factors including: 1) the initiating stimulus or trigger, 2) the cell types involved in the response, and 3) the specific effector cytokine-chemokine milieus produced. The compilation of these and other factors in a given mechanistic context is sometimes referred to as ...
Slavish Danica C DC The Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA - - 2014
There is burgeoning interest in the ability to detect inflammatory markers in response to stress within naturally occurring social contexts and/or across multiple time points per day within individuals. Salivary collection is a less invasive process than current methods of blood collection and enables intensive naturalistic methodologies, such as those ...
Ueland Thor T Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet; Faculty of Medicine, University of Oslo; K.G. Jebsen Inflammatory Research Center, University of Oslo; KG Jebsen Thrombosis Research and Expertise Center, N-9037 Tromsø, Norway. Electronic address: - - 2014
Inflammation has been implicated in the pathogenesis of heart failure (HF). In addition to their direct involvement as mediators in the pathogenesis of HF, inflammatory cytokines and related mediators could also be suitable markers for risk stratification and prognostication in HF patients. Many reports have suggested that inflammatory cytokines may ...
Fernandes Patricia D PD Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Laboratório de Farmacologia da Dor e da Inflamação. Av. Carlos Chagas Filho, 373. Prédio do CCS, bloco J, sala 10, 21941-902. Rio de Janeiro, Brazil. Electronic address: - - 2014
Convolutamydine A is an oxindole alkaloid that can be isolated from a marine bryozoan. Due to the variety of biological effects, two analogues were synthesised and their anti-inflammatory properties were evaluated. The anti-inflammatory effects of convolutamydine A and its analogues (ISA003 and ISA147) were investigated in a formalin-induced licking behavior ...
Das Lopa M LM Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, - - 2014
Injury initiates recruitment of macrophages to support tissue repair however, excessive macrophage activity may exacerbate tissue damage causing further destruction and subsequent delay in wound repair. Here we show that the PPAR-γ agonist, rosiglitazone (Rosi), a medication recently re-introduced as a drug to treat diabetes and with known anti-inflammatory properties, ...
Lee Woo Hyung WH 1 Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul, - - 2014
Abstract The ethanol extract of fermented soybean from Glycine max (chungkookjang, CHU) has been claimed to have chemopreventive and cytoprotective effects. In the present study, we examined the inhibitory effect of CHU on inducible nitric oxide synthase (iNOS) and cytokine induction by toll-like receptor (TLR) ligands treatment and attempted to ...
Wang Bin B Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Duke University, Durham, NC 27710, - - 2014
Activation of the inflammatory response is accompanied by a metabolic shift to aerobic glycolysis. Here we identify histone deacetylase 4 (HDAC4) as a new component of the immuno-metabolic program. We show that HDAC4 is required for efficient inflammatory cytokine production activated by lipopolysaccharide (LPS). Surprisingly, prolonged LPS treatment leads to ...
Seow Lay-Jing LJ School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia. Electronic address: - - 2014
Gynura segetum, family Compositae, is a cultivated species and can be found growing in the tropical regions of Indonesia and Malaysia. The plant is known for its use for the treatment of cancer, inflammation, diabetes, hypertension and skin afflictions. In the current study, in vivo anti-inflammatory effect of the methanol ...
Ghosh Chiranjit - - 2014
Dictamnus dasycarpus is widely used as a traditional remedy for the treatment of eczema, rheumatism, and other inflammatory diseases in Asia. The current study investigates the molecular mechanism of anti-inflammatory action of the ethanol extract of Dictamnus dasycarpus leaf (DE) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Nitric oxide (NO) production ...
Dios Sonia S 1 Instituto de Investigaciones Marinas (IIM)-Consejo Superior de Investigaciones Científicas (CSIC) , Vigo, Spain - - 2014
Abstract Septic shock is the most common cause of death in intensive care units due to an aggressive inflammatory response that leads to multiple organ failure. However, a lipopolysaccharide (LPS) tolerance phenomenon (a nonreaction to LPS), is also often described. Neither the inflammatory response nor the tolerance is completely understood. ...
Hiramatsu Yukihiro Y Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka 814-0180, - - 2014
Genomic DNA has been identified as an anti-inflammatory component of Lactobacillus species, the effects of which are mediated through toll-like receptor (TLR) 9. In this study, we identified 14 novel anti-inflammatory oligodeoxynucleotide (ODN) from the genomic DNA of Lactobacillus casei by measuring their effects on the secretion of interleukin (IL)-8 ...
Ying Chen C Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing, PR - - 2014
The aim of this investigation was to study the anti-nociceptive and anti-inflammatory activities of Stauntonia chinensis (S. chinensis) and the possible action mechanisms of effective fractions. The anti-nociceptive and anti-inflammatory activities of S. chinensis extracts, including the 60% EtOH extract (YMG), the n-BuOH extract (YMGB) and the aqueous residue (YMGW) ...
Fan Hui H King's Lab, Shanghai Jiao Tong University School of Pharmacy, 800 Dongchuan Road, Shanghai 200240, - - 2014
We recently reported that the glucagon-like peptide-1 receptor (GLP-1R) peptidic agonists exenatide and GLP-1 produced anti-hypersensitive effects in neuropathic, cancer and diabetic pain. In this study, we investigated the anti-allodynic and anti-hyperalgesic effects of the nonpeptidic agonist WB4-24 in inflammatory nociception and possible involvements of microglial β-endorphin and pro-inflammatory cytokines. ...
Li Bin B Department of Pharmacy, Qingdao University of Science & Technology, Qingdao 266042, P. R. - - 2014
Amomum tsao-ko Crevost et Lemaire, used as a spice in Asia, is an important source of Chinese cuisine and traditional Chinese medicines. A. tsao-ko is reported to exert a variety of biological and pharmacological activities, including anti-proliferative, anti-oxidative and neuroprotective effects. In this study, NNMBS227, consisting of the ethanol extract ...
Moran Ellen M EM Institute for Immunology & Infectious Diseases (IIID), Murdoch University, Murdoch, WA, - - 2014
The idiopathic inflammatory myopathies are a heterogeneous group of disorders characterised by diffuse muscle weakness and inflammation. A common immunopathogenic mechanism is the cytokine driven infiltration of immune cells into the muscle tissue. Recent studies have dissected further the inflammatory cell types and associated cytokines involved in the immune-mediated myopathies ...
Vega Virginia L VL Research and Development Division, SkinMedica, Inc., Carlsbad, CA, 92008, - - 2014
Macrophages (Mϕs) play an important role in the inflammatory response during injury by participating in the removal of injurious stimuli, such as bacteria, and promoting tissue healing to restore homeostasis. Mϕs can acquire distinct functional phenotypes along a spectrum between two opposite stages (M1/M2) during activation. In the present study, ...
Martelli Davide D Florey Institute of Neuroscience and Mental - - 2014
Following an immune challenge, there is two-way communication between the nervous and immune systems. It is proposed that a neural reflex - the inflammatory reflex - regulates the plasma levels of the key pro-inflammatory cytokine tumor necrosis factor α (TNFα), and that its efferent pathway is in the splanchnic sympathetic ...
Sullivan Catherine B - - 2014
Mesenchymal stem cells (MSC) have the ability to repair and regenerate tissue, home to sites of inflammation and evade the host immune system. As such, they represent an attractive therapy for the treatment of autoimmune inflammatory diseases. However; results from in-vivo murine studies in inflammatory arthritis have been conflicting, which ...
Lappas M M Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia; Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia. Electronic address: - - 2014
Members of the NR4A subfamily are involved in a wide range of diseases including obesity and diabetes. The aim of this study was to determine the effect of maternal obesity and gestational diabetes mellitus (GDM) on the expression of the NR4A receptors Nurr1, Nur77 and NOR1. Human placenta was obtained ...
Mateos Melina V MV Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), Universidad Nacional del Sur (UNS) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 8000 Bahía Blanca, Argentina. Electronic address: - - 2014
The retinal pigment epithelium (RPE) plays an important immunological role in the retina and it is involved in many ocular inflammatory diseases that may end in loss of vision and blindness. In this work the role of phospholipase D (PLD) classical isoforms, PLD1 and PLD2, in the inflammatory response of ...
Yang Jae-Wook JW Department of Ophthalmology, Busan Paik Hospital, College of Medicine Inje University , Busan , Republic of Korea - - 2014
Abstract Context: Expression of various inflammatory mediators in corneal fibroblasts contributes to corneal inflammation. Objective: The purpose of this study was to assess the possible effects of caffeic acid phenethyl ester (CAPE) on the expression of inflammatory mediators during an inflammatory response in human corneal fibroblasts. Materials and methods: The ...
Lim Mei Xing MX Department of Microbiology, Yong Loo Lin School of Medicine Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore 117597, - - 2014
Blastocystis is a common enteric protistan parasite that can cause acute as well as chronic infection and is associated with irritable bowel syndrome (IBS). However, the pathogenic status of Blastocystis infection remains unclear. In this study, we found that Blastocystis antigens induced abundant expression of pro-inflammatory cytokines including IL-1β, IL-6 ...
Ferrari Giulio G Cornea and Ocular Surface Disease Unit, Eye Repair Lab, San Raffaele Scientific Institute, San Raffaele Hospital, Via Olgettina 60, Milan, 20122, Italy - - 2014
Purpose. To test whether a corneal injury can stimulate inflammation in the trigeminal ganglion (TG), a structure located in the brain. Methods. After 4 and 8 days from alkali burn induced in the right eye of mice, in vivo MRI of the brain was done before and after USPIO contrast ...
Lopes-Ferreira Mônica M Immunoregulation Unit, Special Laboratory of Applied Toxinology (Cepid/Fapesp), Butantan Institute, São - - 2014
This is the first report describing in mice the envenoming that possible to occur in humans provoked by P. fasciatum and evaluated the different class of mediators involved in the inflammatory injury, identifying important targets for drugs intervention. First we demonstrate that P. fasciatum venom induces an acute inflammatory response ...
Bro-Jeppesen John J Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Denmark. Electronic address: - - 2014
Survivors after cardiac arrest (CA) exhibits a systemic inflammatory response as part of post-cardiac arrest syndrome (PCAS). We investigated the association between systemic inflammation and severity of PCAS and whether level of targeted temperature management (TTM) modifies level of the inflammatory response. We studied 169 patients included at a single ...
Mirantes Cristina C The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA 94143, - - 2014
Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the regulatory factors that maintain proper HSC function and lineage output under normal conditions are well understood, significantly less is known about how HSC ...
Bury Matthew I MI Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Pediatric Urology, Chicago, IL 60614, - - 2014
Current attempts at tissue regeneration utilizing synthetic and decellularized biologic-based materials have typically been met in part by innate immune responses in the form of a robust inflammatory reaction at the site of implantation or grafting. This can ultimately lead to tissue fibrosis with direct negative impact on tissue growth, ...
Freitas Marisa M REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal. Electronic address: - - 2014
Neutrophils are considered the central cells of acute inflammation. Flavonoids have been suggested as therapeutic agents to avoid damages induced by inflammatory processes. It is well known the reactivity of flavonoids with hypochlorous acid produced by neutrophils, to form stable mono and dichlorinated products. In this study, we synthesized novel ...
Rajendran Peramaiyan P NPO-International Laboratory of Biochemistry, 1-166, Uchide, Nakagawa-ku, Nagoya 454-0926, - - 2014
Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many edible plants (e.g., tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries, and grapes) and in plants or botanical products commonly used in traditional medicine (e.g., Ginkgo biloba, Tilia spp, Equisetum spp, Moringa oleifera, Sophora japonica and propolis). Its anti-oxidant/anti-inflammatory effects have ...
Davidovich Pavel - - 2014
Abstract Microbial infection and tissue injury are well established as the two major drivers of inflammation. However, although it is well established that necrotic cell death can trigger or potentiate inflammation, precisely how this is achieved still remains relatively obscure. Certain molecules, which have been dubbed 'damage-associated molecular patterns' (DAMPs) ...
Leite Fagner Carvalho FC Laboratório de Imunofarmacologia, Departamento de Fisiologia e Patologia, UFPB, João Pessoa, Paraíba, - - 2014
Curine is a bisbenzylisoquinoline alkaloid that is isolated from Chondrodendron platyphyllum, a plant that is used to treat malaria, inflammation, and pain. Recent reports have demonstrated the antiallergic effects of curine at nontoxic doses. However, its anti-inflammatory and analgesic properties remain to be elucidated. This study investigated the anti-inflammatory and ...
de Lima V T VT Faculties Biological and Environmental Sciences, Federal University of Grande Dourados UFGD, MS, - - 2014
The essential oil from the leaves of Ocimum kilimandscharicum (EOOK), collected in Dourados-MS, was investigated for anticancer, anti-inflammatory and antioxidant activity and chemical composition. The essential oil was extracted by hydrodistillation, and the chemical composition was performed by gas chromatography-mass spectrometry. The essential oil was evaluated for free radical-scavenging activity ...
Wen Ti T Department of Medical Oncology, First Hospital of China Medical University , Shengyang 110001, - - 2014
We have previously demonstrated that DCB-3503, a tylophorine analogue, has an anti-inflammatory property in murine models for autoimmune diseases. However, its mechanism remains unknown. Here, we have synthesized 34 derivatives of DCB-3503 and investigated their effects on T cells differentiation and TNF-α production. Six derivatives (4, 9, 13, 19, 31, ...
Kuhny Marcel - - 2014
Mast cells (MCs) are major contributors to an inflammatory milieu. One of the most potent drivers of inflammation is the cytokine IL-1β, which is produced in the cytoplasm in response to danger signals like LPS. Several controlling mechanisms have been reported which limit the release of IL-1β. Central to this ...
Drummond Peter D PD Centre for Research on Chronic Pain and Inflammatory Diseases, Murdoch University, Perth, Western Australia, - - 2014
Under normal conditions, the sympathetic neurotransmitter noradrenaline inhibits the production and release of pro-inflammatory cytokines. However, after peripheral nerve and tissue injury, pro-inflammatory cytokines appear to induce the expression of the alpha1A-adrenoceptor subtype on immune cells and perhaps also on other cells in the injured tissue. In turn, noradrenaline may ...
Takimoto Koyo K Department of Pulp Biology and Endodontics, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, - - 2014
Matrix metalloproteinase (MMP)-3 is a member of the MMP family that degrades the extracellular matrix. Application of MMP-3 to injured pulp tissue induces angiogenesis and wound healing, but its anti-inflammatory effects are still unclear. Here, we evaluated the anti-inflammatory functions of MMP-3 in vitro and in vivo. Nitric oxide and inflammatory mediator ...
Wang Hui H Department of Vascular and Endocrine Surgery, Xijing Hospital, Fourth Military Medical University, No. 15 Changle West Road, Xi'an, Shaanxi 710032, - - 2014
Volatile anesthetic isoflurane (ISO) has immunomodulatory effects. The fungal component zymosan (ZY) induces inflammation through toll-like receptor 2 or dectin-1 signaling. We investigated the molecular actions of subanesthetic (0.7%) ISO against ZY-induced inflammatory activation in murine Kupffer cells (KCs), which are known as the resident macrophages within the liver. We ...
Ojha Durbadal D ICMR Virus Unit, I.D. & B.G. Hospital, Beliaghata, Kolkata, India; Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, - - 2014
Inflammation is part of self-limiting non-specific immune response, which occurs during bodily injury. In some disorders the inflammatory process becomes continuous, leading to the development of chronic inflammatory diseases including cardiovascular diseases, diabetes, cancer etc. Several Indian tribes used the bark of Odina wodier (OWB) for treating inflammatory disorders. Thus, ...
Szabo Attila A Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Research Centre for Molecular Medicine, University of Debrecen, Debrecen, - - 2014
The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation and cell survival, and mediates anti-inflammatory responses and immunosuppression in murine in vivo models. Since the details of these findings have ...
Fasano Elena E 0000-0002-4040-876X Institute of General Pathology, Catholic University, 00168 Rome, - - 2014
Several advantages may derive from the use of dietary supplements containing multiple natural antioxidants and/or anti-inflammatory agents. At present, however, there is scarce information on the properties and potential of combined supplements. To fill the gap, the antioxidant and anti-inflammatory activities exerted by a combination of seven natural components (coenzyme ...
Shimada Tadayuki T 0000-0001-7333-9847 Neural Plasticity Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, - - 2014
Epilepsy is one of the most common chronic brain disorders worldwide, affecting 1% of people across different ages and backgrounds. Epilepsy is defined as the sporadic occurrence of spontaneous recurrent seizures. Accumulating preclinical and clinical evidence suggest that there is a positive feedback cycle between epileptogenesis and brain inflammation. Epileptic ...
Castro Jenny P - - 2014
Despite Cryptostegia grandiflora Roxb. ex R. Br. (Apocynaceae) leaves are widely used in folk Caribbean Colombian medicine for their anti-inflammatory effects, there are no studies that support this traditional use. Therefore, this work aimed to evaluate the effect of the total extract and primary fractions obtained from Cryptostegia grandiflora leaves, ...
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