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Singh Ajeet Kumar AK Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, 221005, - - 2014
Reactive oxygen species are signaling mediators of nociceptive pathways. Exogenous administrations of antioxidants show anti-hyperalgesic effect. However, very little is known about the role of endogenous antioxidant defense system in pain pathology. Curcumin is a dietary antioxidant which shows ameliorative effect on thermal hypersensitivity, however detailed study is lacking. Present ...
Korf Hannelie H Clinical and Experimental Endocrinology, Department of Experimental and Clinical Medicine, KU Leuven, Leuven, - - 2014
Current data clearly support an interaction of vitamin D with cells of the immune system apart from its regulatory role in calcium homeostasis. The discovery that immune cells express the vitamin D receptor and are capable of metabolizing circulating 25-hydroxyvitamin D into its active form, 1,25-dihydroxyvitamin D, has revolutionized the ...
Fabre-Mersseman Véronique V aSorbonne Universités, UPMC Univ Paris, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris) bINSERM, U1135, CIMI-Paris cSorbonne université, UPMC Univ Paris 06, UMR_S 1136 Pierre Louis Institute of Epidemiology and Public Health dINSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique eAP-HP, Groupe hospitalier Pitié-Salpêtrière, Service des Maladies Infectieuses et Tropicales fAP-HP, Hôtel-Dieu, Centre de Diagnostic et de Thérapeutique gCochin Hospital, Infectious Pathology Unit, France and Paris Descartes University, Infectious Pathology Unit hEA 7327 Université Paris-Descartes, Sorbonne Paris Cité, Paris, - - 2014
A majority of HIV-1-infected patients present a severe deficit in vitamin D, which predicts short-term mortality. Vitamin D is a naturally synthesized hormone, with important immunomodulatory functions. In the general population, its deficit has been associated with increased markers of inflammation. Vitamin D deficit may therefore play a role in ...
Bizzaro Giorgia G The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, 52621, Tel-Hashomer, Tel Aviv, - - 2014
Vitamin D deficiency (levels lower than 20 ng/ml) is becoming a global health problem, since it is increasingly represented even among healthy subjects. Vitamin D, as an environmental factor, is involved in many biological processes, like perception of chronic pain and response to infections. In recent years, evidence has emerged pointing ...
Katz Oksana O The Faculty of Agriculture, Food and Environmental Sciences, The School of Nutritional Sciences, The Hebrew University of Jerusalem, 76100, Rehovot, - - 2014
Anemia of chronic disease is frequently seen in chronic inflammatory conditions. Its hallmark is disrupted iron homeostasis, with increased uptake and retention of iron in cells of the reticuloendothelial system. Using the Caco-2 cell line as an in vitro model for iron absorption, local intestinal iron-related protein dynamics were evaluated ...
Mauf Sabrina S Division of Endocrinology & Metabolism, Department of Internal Medicine, Goethe-University Hospital, Theodor-Stern-Kai, Frankfurt am Main, - - 2014
Preventive measures and a causal therapy for type 1 diabetes (T1D) remain elusive. An imbalance between different dendritic cells (DC) with increased immunogenic DC and decreased tolerogenic DC (tDC) may lead to T1D. Furthermore, 25(OH)D3 is associated with less adverse effects than 1,25(OH)2D3. The present study was performed to clarify ...
Zhan Yunfei Y Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China ; Department of Internal Medicine, Shandong Provincial Chest Hospital, Jinan, Shandong 250013, P.R. - - 2015
Pulmonary tuberculosis (PTB) is a high burden infectious disease in China. The immune function is damaged in patients with diabetes mellitus (DM) who are easy to infect with Mycobacterium tuberculosis (Mtb). The growth of Mtb has been shown to be restrained following the administration of vitamin D and antimicrobial peptide ...
Guillot Xavier X Department of rheumatology, Besançon University Hospital, Boulevard Fleming, 25030, Besançon, - - 2014
In cross-sectional studies, vitamin D deficiency is frequent in spondyloarthritic patients and associated with increased spondyloarthritis (SpA) activity and structural damage. Experimental studies also show that vitamin D interferes with molecular pathways critically involved in SpA, especially regarding entheseal inflammation and ossification (involving cytokines such as IL-23 and sclerostin). Vitamin ...
Zhu Linnan L 1Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, - - 2014
Macrophages are a functionally heterogeneous cell population that is mainly shaped by a variety of microenvironmental stimuli. Interferon γ (IFN-γ), interleukin-1β (IL-1β), and lipopolysaccharide (LPS) induce a classical activation of macrophages (M1), whereas IL-4 and IL-13 induce an alternative activation program in macrophages (M2). Reprogramming of intracellular metabolisms is required ...
Kunisawa Jun J Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan. - - 2014
The host immune system is regulated not only by endogenous factors, such as cytokines and chemokines, but also by exogenous factors, such as commensal bacteria and dietary materials. Vitamins are vital nutrients that are mainly derived from the diet and commensal bacteria. Accumulating evidence has revealed specific functions of vitamins ...
Wang Shu - - 2014
ABSTRACT Iodoacetic acid (IAA) is an unregulated drinking-water disinfection by-product with potent cytotoxicity, genotoxicity and tumorigenicity in animals. Oxidative stress is thought to be essential for IAA toxicity, but the exact mechanism remains unknown. Here we evaluate the toxicity of IAA by examining nuclear factor E2-related factor 2 (Nrf2)-mediated antioxidant ...
Esterházy Daria D Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, - - 2014
Vitamin A plays pleiotropic roles in the immune system. A recent eLife paper by Hooper and colleagues shows that hepatic and intestinal serum amyloid A proteins, which are induced in response to infection, can transport vitamin A metabolites to tissues and thus impact immune responses both locally and systemically.
Bakdash Ghaith G Department of Cell Biology & Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, The - - 2014
Vitamin D is recognized as a potent immunosuppressive drug. The suppressive effects of vitamin D are attributed to its physiologically active metabolite 1,25 dihydroxy vitamin D3 (calcitriol), which was shown, to prime dendritic cells (DCs) to promote the development of regulatory T (Treg) cells. Despite the potential benefit in treating ...
Britt Rodney D RD Jr Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, - - 2014
Asthma in the pediatric population remains a significant contributor to morbidity and increasing healthcare costs. Vitamin D3 insufficiency and deficiency have been associated with development of asthma. Recent studies in models of adult airway diseases suggest that the bioactive Vitamin D3 metabolite, calcitriol (1,25-dihydroxyvitamin D3 ; 1,25(OH)2 D3 ), modulates ...
van der Eerden Bram C J BC Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. Electronic address: - - 2014
We present a brother and sister with severe rickets, alopecia and highly elevated serum levels of 1,25-dihydroxyvitamin D (1,25-(OH)2D3). Genomic sequencing showed a homozygous point mutation (A133G) in the vitamin D receptor gene, leading to an amino acid change in the DNA binding domain (K45E), which was described previously. Hereditary ...
Zhang Xiao-Liang XL Institute of Nephrology, Zhong Da Hospital, SE University School of Medicine, Nanjing, Jiangsu 210009, - - 2014
Increasing evidences suggest the heterogeneity of macrophage phenotype and function ultimately determines the outcome of diabetic nephropathy (DN). The study aimed to investigate the effects of vitamin D on macrophages M1/M2 phenotype and its role in preventing podocytes impairment in streptozocin (STZ)-induced DN rats. Calcitriol, a bioactive 1,25-dihydroxyvitamin D3, ameliorated ...
Harishankar M M Department of Immunology, National Institute for Research in Tuberculosis (Formerly Tuberculosis Research Centre), Indian Council of Medical Research, 1, Mayor Sathyamoorthy Road, Chetput, Chennai 600 031, - - 2014
1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] is a potent immunomodulator and regulates various immune responses to Mycobacterium tuberculosis (Mtb). The present study aimed to understand the effect of 1,25(OH)2D3 on pro-inflammatory cytokine response to Mtb antigen. Peripheral blood mononuclear cells from 42 healthy controls (HCs) and 42 pulmonary tuberculosis (PTB) patients were ...
Zoico Elena E Department of Medicine, Division of Geriatrics, University of Verona, 10-37134 Verona, - - 2014
Recent experimental data seem to suggest a relevant role for 1,25[OH]2cholecalciferol (1,25[OH]2D3) in adipocyte physiology and pathophysiology, with some studies showing adipogenic and pro-inflammatory properties, and others lipolytic and anti-inflammatory functions. Moreover, to our knowledge, the role of cholecalciferol (D3) in adipocytes function is still not known. Therefore, the aim ...
Menezes Arthur R AR aDepartment of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School- The University of Queensland School of Medicine bDepartment of Preventive Cardiology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana cMid America Heart Institute, Kansas City, Missouri, - - 2014
To provide an overview of the association between vitamin D deficiency and atherosclerosis. Vitamin D exerts protective effects on atherosclerosis through multiple mechanisms. It has been shown to protect against endothelial dysfunction, vascular smooth muscle cell proliferation and migration, and modulation of the immune system, as well as the inflammatory ...
Fabiś Jaroslaw J Department of Arthroscopy, Minimally Invasive Surgery and Sports Traumatology, Medical University of Łódź, Łódź, Poland; FMC Private Medical Centre, Łódź, Poland. Electronic address: - - 2014
We hypothesize that the expression of proapoptotic and antiapoptotic molecules and cytokines is dependent on the distance from the torn supraspinatus tendon edge and this expression may influence its potential for healing. The aim of this work is to evaluate the expression of proapoptotic Bax molecule and caspases 3, 8, ...
Lundgreen Kirsten K Department of Orthopaedic Surgery, Lovisenberg Diaconal Hospital, Oslo, Norway. Electronic address: - - 2014
The purpose of this study was to assess the effect of smoking on supraspinatus tendon degeneration, including cellular alterations, proliferation, and apoptosis of tendon cells. Supraspinatus tendon samples of 10 smokers and 15 nonsmokers with full-thickness tears were compared, focusing on the severity of tendon histopathology including apoptosis (programmed cell ...
Andarawis-Puri Nelly N Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, New - - 2014
Accumulation of damage is a leading factor in the development of tendinopathy. Apoptosis has been implicated in tendinopathy, but the biological mechanisms responsible for initiation and progression of these injuries are poorly understood. We assessed the relationship between initial induced damage and apoptotic activity 3 and 7 days after fatigue ...
Sugg Kristoffer B KB Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, Biomedical Science Research Building, Room 2017, Ann Arbor, Michigan; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan; Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, - - 2014
Tendon injuries occur frequently in physically active individuals, but the clinical outcomes for these injuries can be poor. In many injured tissues the repair process is orchestrated by two types of cells, macrophages and fibroblasts. Macrophages, which have both pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes, can directly participate in tissue ...
Dakin Stephanie G SG Royal Veterinary College, Department of Clinical Sciences and Services, North Mymms, Hatfield, Hertfordshire AL9 7TA, United Kingdom. Electronic address: - - 2014
Injuries to the superficial digital flexor tendon (SDFT) are an important cause of morbidity and mortality in equine athletes, but the healing response is poorly understood. One important drive for the healing of connective tissues is the inflammatory cascade, but the role of inflammation in tendinopathy has been contentious in ...
Manning Cionne N CN Department of Orthopaedic Surgery, Washington University, 425 South Euclid, Campus Box 8233, St Louis, Missouri, - - 2014
Despite advances in surgical techniques over the past three decades, tendon repairs remain prone to poor clinical outcomes. Previous attempts to improve tendon healing have focused on the later stages of healing (i.e., proliferation and matrix synthesis). The early inflammatory phase of tendon healing, however, is not fully understood and ...
Wei Wei W Department of Ophthalmology, Inner Mongolia People's Hospital, 20 Zhaowuda Road, Hohhot, Inner Mongolia 010017, - - 2014
The purpose was to investigate the protective effects of Vitamin C (Vit C) and the regulatory mechanism between Vit C and sirtuin 1 (SIRT1) in PREs during oxidative stress as Vit C and SIRT1 exerted famous effects as antioxidants. We found that moderate Vit C (100 µM) prevented ARPE-19 cells from ...
Allegra M M Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Università di Palermo, Via M. Cipolla 74, Palermo 90123, - - 2014
Macrophages come across active prostaglandin (PG) metabolism during inflammation, shunting early production of pro-inflammatory towards anti-inflammatory mediators terminating the process. This work for the first time provides evidence that a phytochemical may modulate the arachidonate (AA) metabolism in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, promoting the ultimate formation of anti-inflammatory cyclopentenone ...
Vetvicka Vaclav V Department of Pathology, University of Louisville, Louisville, KY 40202, USA. - - 2014
Stress has repeatedly been found to reduce the abilities of the immune system to fight against individual attacks. The current dissatisfaction with classical medications has led to more attention being focused on natural molecules. As recent studies have suggested that some bioactive molecules can have synergistic effects in stimulation of ...
Chen Yuanyuan Y Respiratory Section, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, - - 2014
Oxidative stress is an important part of host innate immune response to foreign pathogens. However, the impact of vitamin C on oxidative stress and inflammation remains unclear in community-acquired pneumonia (CAP). We aimed to determine the effect of vitamin C on oxidative stress and inflammation. CAP patients were enrolled. Reactive ...
Mohammed Bassem M BM Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, VA 23298-0533, USA ; Department of Clinical Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, - - 2014
Introduction. Macrophage reprogramming is vital for resolution of acute inflammation. Parenteral vitamin C (VitC) attenuates proinflammatory states in murine and human sepsis. However information about the mechanism by which VitC regulates resolution of inflammation is limited. Methods. To examine whether physiological levels of VitC modulate resolution of inflammation, we used ...
Selvaraju Thilaga Rati TR Biochemistry Unit, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, 43400 Selangor, Malaysia. - - 2014
Tocotrienol rich fraction (TRF) is an extract of palm oil, which consists of 25% alpha tocopherol (α-TCP) and 75% tocotrienols. TRF has been shown to possess potent antioxidant, anti-inflammatory, anticancer, neuroprotection, and cholesterol lowering activities. Glutamate is the main excitatory amino acid neurotransmitter in the central nervous system of mammalian, ...
Jin Xiaoting X Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, - - 2014
Dichlorodiphenoxytrichloroethane (DDT) is a known persistent organic pollutant and liver damage toxicant. However, there has been little emphasis on the mechanism underlying liver damage toxicity of DDT and the relevant effective inhibitors. Hence, the present study was conducted to explore the protective effects of vitamin C (VC) and vitamin E ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0107564.].
Lee Hyo-Jin - - 2013
BACKGROUND:Even though apoptosis is known to be closely associated with rotator cuff tears, the differences in apoptosis according to the location within the torn supraspinatus tendon are still unknown. PURPOSE:To elucidate where apoptosis begins within the supraspinatus tendon. STUDY DESIGN:Controlled laboratory study. METHODS:Tendon tissues were collected from 14 patients undergoing ...
Wu Ya Fang - - 2013
Early flexor tendon healing is characterized by peak cellular apoptosis of both inflammatory and tendon cells in the first week, followed by progressively greater tenocyte proliferation in the second and third weeks. Tenocyte apoptosis is a predominant event, but proliferation of tenocytes is minimal in the middle and late healing ...
Mobasheri A - - 2013
Tendonitis and tendinitis are terms used to describe an inflamed and painful tendon. Tendinopathy, is a descriptive term for describing clinical conditions arising from tendon injury and overuse both within and around tendons. The aim of this mini-review is to explore the role of pro-inflammatory cytokines, particularly interleukin-1β (IL-1β) in ...
Millar Neal L - - 2013
Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care in the UK and account for up to 30% of rheumatological consultations. While the molecular pathophysiology of tendinopathy remains incompletely understood, recent observations concerning repetitive stress and cellular load provide important mechanistic insight implicating a role for tissue alarmins. ...
de Girolamo L - - 2013
Low frequency pulsed electromagnetic field (PEMF) has proven to be effective in the modulation of bone and cartilage tissue functional responsiveness, but its effect on tendon tissue and tendon cells (TCs) is still underinvestigated. PEMF treatment (1.5 mT, 75 Hz) was assessed on primary TCs, harvested from semitendinosus and gracilis tendons ...
Lundgreen Kirsten - - 2012
PURPOSE: The role of apoptosis in the progression of rotator cuff tendinopathy remains poorly understood. In particular, the extent of apoptosis in the partially torn supraspinatus tendon has not been well examined. METHODS: Biopsies were obtained from nine partially torn supraspinatus tendons, from the matched intact subscapularis tendons, and from ...
Ackermann P W - - 2012
PURPOSE: The aim of this study was to assess inflammation and the presence and relative levels of cytokines, which may be involved in regulating early human Achilles tendon healing. METHODS: Nine patients with acute Achilles tendon rupture were included, operated on and post-operatively immobilized. Two weeks post-operatively, microdialysis of the ...
Ambade Aditya A Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, - - 2012
Endotoxin-mediated proinflammatory cytokines play a significant role in the pathogenesis of acute and chronic liver diseases. Heat shock protein 90 (molecular weight, 90 kDa) (hsp90) functions as an important chaperone of lipopolysaccharide (LPS) signaling and is required for the production of proinflammatory cytokines. We hypothesized that inhibition of hsp90 would ...
Colombo Paolo C PC Department of Medicine, Division of Cardiology, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY, USA. - - 2012
Although inflammation is a physiologic response designed to protect us from infection, when unchecked and ongoing it may cause substantial harm. Both chronic heart failure (CHF) and chronic kidney disease (CKD) are known to cause elaboration of several pro-inflammatory mediators that can be detected at high concentrations in the tissues ...
Karper Jacco C - - 2012
New circulating and local arterial biomarkers may help the clinician with risk stratification or diagnostic assessment of patients and selecting the proper therapy for a patient. In addition, they may be used for follow-up and testing efficacy of therapy, which is not possible with current biomarkers. Processes leading to postinterventional ...
Yang Xuechao - - 2012
Postnatal dental pulp stem cells (DPSCs) represent a unique precursor population in the dental pulp, which have multipotential and harbor great potential for tissue engineering purposes. However, for therapy applications, transplanted cells are often exposed to unfavorable conditions such as cytokines released from necrotic or inflammatory cells in injured tissues. ...
Costa Alessandro A Elie Metchnikoff Department, University of Messina, Messina I-98125, - - 2012
Group B Streptococcus (GBS) is a frequent agent of life-threatening sepsis and meningitis in neonates and adults with predisposing conditions. We tested the hypothesis that activation of the inflammasome, an inflammatory signaling complex, is involved in host defenses against this pathogen. We show in this study that murine bone marrow-derived ...
Sunaga Takafumi - - 2012
Canine osteoarthritis occurs frequently and causes secondary synovitis. Administration of non-steroidal anti-inflammatory drugs (NSAIDs) is one of major therapeutic options for pain management of joint diseases. Tepoxalin has an unique property as NSAIDs, which suppress both cyclooxygenase and lipoxygenase. The purpose of this study was to evaluate anti-proliferative effects of ...
Kvarnström Andreas L - - 2012
Study Objective:  The objective of this study was to evaluate whether major abdominal surgery leads to complement activation and interleukin response and whether the kind of anaesthesia influence complement activation and the release of inflammatory interleukins. Design:  Prospective and randomised trial. Setting:  Operating room and in the postoperative recovery area. ...
Schafer Peter - - 2012
Psoriasis and psoriatic arthritis are common clinical conditions that negatively impact health-related quality of life and are linked to serious medical comorbidities. Disease mechanisms involve local and systemic chronic inflammatory processes. Available biologic therapies specifically target single inflammatory mediators, such as tumor necrosis factor-α (TNF-α), in the context of a ...
Jungbauer Alois - - 2012
Obesity and metabolic syndrome are increasing global health problems. In addition to the malnutrition of a sedentary lifestyle, high calorie intake leads to obesity with many negative health consequences. Macrophages infiltrate adipose tissue and induce chronic inflammation by secreting pro-inflammatory cytokines, including COX-2 and iNOS, among other mediators of inflammation. ...
Minelli Alba - - 2012
Oxidative stress is a critical contributing factor to neurodegenerative disorders. Therefore, the inhibition of ROS formation, responsible for chronic detrimental neuroinflammation, is an important strategy for preventing the neurodegenerative disease and for neuroprotective therapy. Gly-Pro-Glu (GPE) is the N-terminal tripeptide of insulin-like growth factor-I, which is naturally cleaved in the ...
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