A cigarette alternative is designed to deliver a dose of medicinal nicotine within a timeframe comparable to that of a cigarette, and gives much of what smokers expect from a cigarette without the risks of smoking tobacco. The design concept is the same as a pressurized metered dose inhaler (pMDI), ...

Pellets are frequently used in pharmaceutical applications. The extrusion-spheronization process is a well-established technique used to produce pellets of a spherical shape and narrow size distribution. In this process, cylindrical extrudates are transformed into spherical pellets by spheronization. Most established mechanisms consider only breakage and deformation to explain pellet formation. ...

The elastic properties of pharmaceutical powders play an important role during the compaction process. The elastic behavior can be represented by Young's modulus (E) and Poisson's ratio (v). However, during the compaction, the density of the powder bed changes and the moduli must be determined as a function of the ...

A dielectric pipe waveguide is successfully demonstrated as a terahertz refractive index sensor for powder and liquid-vapor sensing. Without additional engineered structures, a simple pipe waveguide can act as a terahertz resonator based on anti-resonant reflecting guidance, forming multiple resonant transmission-dips. Loading various powders in the ring-cladding or inserting different ...

This article presents a novel application of small and wide angle X-ray scattering (SWAXS) in the assessment of aspirin and lactose content in a binary pharmaceutical powder formulation. It is shown that the content correlates with the intensity of the SAXS signal and the intensity of polymorph fingerprints in the ...

Tablet production involves compression of free flowing powder in an enclosed cavity of defined geometry. The complexity of the powder bed system necessitates that a way be found to better understand what occurs during compression. One such approach is by means of compaction equations, of which, the Heckel and Kawakita ...

A quantum cutting mechanism for the sublinear near-IR power dependence property in Tb³⁺-Yb³⁺ codoped NaYF₄ powders were investigated both experimentally and theoretically. The slopes of Yb³⁺ luminescence intensity versus excitation power were fitted to be between 0.5 and 1. We have developed a quantum cutting rate equation model to explain ...

This is the second part of a two-part paper that develops graph theoretic techniques for the topological transformation and analysis of multibody system dynamics. The first part focused on tree systems, and developed systematic and rigorous techniques for the partitioning, aggregation and sub-structuring of multibody dynamics models. This second part, ...

Hundred micrometers-sized porous hydroxyapatite globules have proved as a successful tissue engineering strategy for bone defects in vivo, as was shown in studies on human mandibles. These granules need to provide enough porous space for bone ingrowth, while maintaining sufficient mechanical competence (stiffness and strength) in this highly load-bearing organ. ...

Abstract Background: The performance of dry powder aerosol delivery systems depends not only on the powder formulation but also on the dry powder inhalers (DPIs). Effects of turbulence, grid, mouthpiece, inlet size, air flow, and capsule on the DPIs performance have been investigated previously. Considering powder dispersion in DPIs is ...

A new chiral sulfide family, Ln4InSbS9 (Ln = La, Pr, Nd) with its own structure type in space group P41212 or its enantiomorph P43212, has been synthesized by solid-state reaction. Remarkably, the La-member shows the strongest Kleinman forbidden second harmonic generation to date with an intensity of 1.5 times commercial ...

Kimberlites are volatile-rich magmas from mantle depths of ≥150 km and are the primary source of diamonds. Kimberlite volcanism involves the formation of diverging pipes or diatremes, which are the locus of high-intensity explosive eruptions. A conspicuous and previously enigmatic feature of diatreme fills are 'pelletal lapilli'-well-rounded clasts consisting of an ...

This paper focuses on the study of the release rate in a family of modified silica mesoporous supports. A collection of solids containing ethyl, butyl, hexyl, octyl, decyl, octadecyl, docosyl and triacontyl groups anchored on the pore outlets of mesoporous MCM-41 has been prepared and characterized. Controlled release from pore ...

A new diadic family of eigenfunctions of the 2D Fourier transform has been discovered. Specifically, new wavelets are derived by steering the elongated Hermite-Gauss filters with respect to rotations, thus obtaining a natural generalization of the Laguerre-Gauss harmonics. Interestingly, these functions are also proportional to their 2D Fourier transform. Their ...

We show that bimodal systems with a spatially nonuniform defocusing cubic nonlinearity, whose strength grows toward the periphery, can support stable two-component solitons. For a sufficiently strong cross-phase-modulation interaction, vector solitons with overlapping components become unstable, while stable families of solitons with spatially separated components emerge. Stable complexes with separated ...

Families of analytical solutions are found for symmetric and antisymmetric solitons in a dual-core system with Kerr nonlinearity and parity-time (PT)-balanced gain and loss. The crucial issue is stability of the solitons. A stability region is obtained in an analytical form, and verified by simulations, for the PT-symmetric solitons. For ...

The usual Weyl calculus is intimately associated with the choice of the standard symplectic structure on [Formula: see text]. In this paper we will show that the replacement of this structure by an arbitrary symplectic structure leads to a pseudo-differential calculus of operators acting on functions or distributions defined, not ...

We consider a long-wave oscillatory Marangoni convection in a layer of a binary liquid in the presence of the Soret effect. A weakly nonlinear analysis is carried out on a hexagonal lattice. It is shown that the derived set of cubic amplitude equations is degenerate. A three-parameter family of asynchronous ...

We show that a fundamental feature of the three-level:two-level model, used to describe molecular monomode lasers with a saturable absorber, is the existence of isolas of periodic passive Q-switching (PQS) self-pulsations. A common feature of these closed families of periodic solutions is that they contain regions of stability of the ...

Unobscured optical systems have been in production since the 1960s. In each case, the unobscured system is an intrinsically rotationally symmetric optical system with an offset aperture stop, a biased input field, or both. This paper presents a new family of truly nonsymmetric optical systems that exploit a new fabrication ...

The simple mechanistic and functional division of the kinesin family into either active translocators or non-motile microtubule depolymerases was initially appropriate but is now proving increasingly unhelpful, given evidence that several translocase kinesins can affect microtubule dynamics, whilst non-translocase kinesins can promote microtubule assembly and depolymerisation. Such multi-role kinesins act ...

For a given pure state of a composite quantum system we analyze the product of its projections onto a set of locally orthogonal separable pure states. We derive a bound for this product analogous to the entropic uncertainty relations. For bipartite systems the bound is saturated for maximally entangled states ...

The scaling behavior of band gaps, fundamental quantities of exciton, i.e. reduced mass, size, and binding strength, of in three families quasi one dimensional graphene nanoribbons with hydrogen passivated armchair shaped edge (AGNRs) is comprehensively investigated by density functional theory with quasi-particle corrections and many body, i.e. electron-hole, interactions. Compared ...

We consider the problem of transport in a one-parameter family of piecewise rotations of the torus, for rotation number approaching 1∕4. This is a zero-entropy system which in this limit exhibits a divided phase space, with island chains immersed in a "pseudo-chaotic" region. We identify a novel mechanism for long-range ...

We report that defocusing cubic media with spatially inhomogeneous nonlinearity, whose strength increases rapidly enough toward the periphery, can support stable bright localized modes. Such nonlinearity landscapes give rise to a variety of stable solitons in all three dimensions, including one-dimensional fundamental and multihump states, two-dimensional vortex solitons with arbitrarily ...

Declining diversification rates over time are a well-established evolutionary pattern, often interpreted as indicating initial rapid radiation with filling of ecological niche space. Here, we test the hypothesis that island radiations may show constant net diversification rates over time, due to continued expansion into new niche space in highly dispersive ...

Coherent states and their generalizations, displaced Fock states, are of fundamental importance to quantum optics. Here we present a direct observation of a classical analogue for the emergence of these states from the eigenstates of the harmonic oscillator. To this end, the light propagation in a Glauber-Fock waveguide lattice serves ...

Solitons in the model of nonlinear photonic crystals with the transverse structure based on two-dimensional (2D) quadratic- or rhombic-shaped Kronig-Penney (KP) lattices are studied by means of numerical methods. The model can also applies to a Bose-Einstein condensate (BEC) trapped in a superposition of linear and nonlinear 2D periodic potentials. ...

We propose a simple model for the realization of symmetrically and antisymmetrically shape-preserving nonlinear waves with nonvanishing intensities at infinity. A finite lattice embedded into a defocusing saturable medium can support various families of novel solitons, including out-of-phase and in-phase solitons with symmetric and antisymmetric profiles. Although the lattice is ...

The profile of the self-preserving far wake with zero net momentum depends on the effective turbulent viscosity coefficient. The current model is based on the assumption of uniform viscosity in the wake cross section. It predicts the self-similar shape of the wake where the width W depends on the distance ...

Interactions between quiescent solitons in Bragg gratings with cubic-quintic nonlinearity and dispersive reflectivity are systematically investigated. In a previous work two disjoint families of solitons were identified in this model. One family can be viewed as the generalization of the Bragg grating solitons in Kerr nonlinearity with dispersive reflectivity (Type ...

Innovations in locomotor morphology have been invoked as important drivers of vertebrate diversification, although the influence of novel locomotion strategies on marine fish diversification remains largely unexplored. Using triggerfish as a case study, we determine whether the evolution of the distinctive synchronization of enlarged dorsal and anal fins that triggerfish ...

Padé spectrum decomposition is an optimal sum-over-poles expansion scheme of Fermi function and Bose function [J. Hu, R. X. Xu, and Y. J. Yan, J. Chem. Phys. 133, 101106 (2010)]. In this work, we report two additional members to this family, from which the best among all sum-over-poles methods could ...

It is well known that two regular tetrahedra can be combined with a single regular octahedron to tile (complete fill) three-dimensional Euclidean space . This structure was called the "octet truss" by Buckminster Fuller. It was believed that such a tiling, which is the Delaunay tessellation of the face-centered cubic ...

We compare the quality factor values of the whispering gallery modes of microdisks (μ-disks) incorporating GaN quantum dots (QDs) grown on AlN and AlGaN barriers by performing room temperature photoluminescence (PL) spectroscopy. The PL measurements show a large number of high Q factor resonant modes on the whole spectrum, which ...

We present the first analytical inspiral-merger-ringdown gravitational waveforms from binary black holes (BBHs) with nonprecessing spins, that is based on a description of the late-inspiral, merger and ringdown in full general relativity. By matching a post-Newtonian description of the inspiral to a set of numerical-relativity simulations, we obtain a waveform ...

This paper presents an analysis of the simultaneous incorporation of force and mass source terms into the multi-relaxation-time (MRT) collision operator. MRT force incorporation was obtained through Chapman-Enskog analysis. The numerical scheme was tested on different benchmark problems, including the decay of a shear wave with different bulk and kinematic ...

We study the existence of a novel complete family of exact and orthogonal solutions of the paraxial wave equation. The complex amplitude of these beams is proportional to the confluent hypergeometric function, which we name hypergeometric modes of type-II (HyG-II). It is formally demonstrated that hyperbolic-index medium can generate and ...

The general quantum χ(2)-divergence has recently been introduced by Temme et al. [Temme K, Kastoryano M, Ruskai M, Wolf M, Verstrate F (2010) J Math Phys 51:122201] and applied to quantum channels (quantum Markov processes). The quantum χ(2)-divergence is not unique, as opposed to the classical χ(2)-divergence, but depends on ...

We study the temporal dynamics of the generalized repressilator, a network of coupled repressing genes arranged in a directed ring topology, and give analytical conditions for the emergence of a finite sequence of unstable periodic orbits that lead to reachable long-lived oscillating transients. Such transients dominate the finite time horizon ...

Periodically structured materials can sustain both optical and mechanical modes. Here we investigate and observe experimentally the optomechanical properties of a conventional two-dimensional suspended photonic crystal defect cavity with a mode volume of ∼3(λ/n)^{3}. Two families of mechanical modes are observed: flexural modes, associated to the motion of the whole ...

We report on the experimental observation of abruptly autofocusing waves. This interesting family of wave packets has been realized by using a radially symmetric Airy intensity distribution. As demonstrated in our experiments, these waves can exhibit unusual features, such as the ability to autofocus by following a parabolic trajectory toward ...

A sample stage is described that allows the on-line analysis of laser intensity profiles and spot sizes directly in the ion source of a matrix-assisted laser desorption ionization (MALDI) mass spectrometer. The detector uses either a scanning knife-edge or a narrow slit in combination with diffusing disks for scattering of ...

The preconcentration of analytes is important in biochemical analysis as it offers the ability to detect for trace species, and increase signal-to-noise ratios when using optical sensing on fluorophores. A strong advantage of the evaporation technique lies in its ability to operate without the need of any energy source; albeit ...

Light absorption by particulate impurities in snow and ice can affect the surface albedo and is important for the climate. The absorption properties of these particles can be determined by collecting and melting snow samples and extracting the particulate material by filtration of the meltwater. This paper describes the optical ...

The optimal diffusion weighting (DW) factor, b, for use in diffusion tensor imaging (DTI) studies remains uncertain. In this study, the geometric relations of DW quantities are examined, in particular, the effects of Rician noise in the measured magnetic resonance signal. This geometric analysis is used to make theoretical predictions ...

The vibrational dynamics of (μ-propanedithiolate)Fe(2)(CO)(4)(CN)(2)(2-), a model compound of the active site of the [FeFe]-hydrogenase enzyme, have been examined via ultrafast 2D-IR spectroscopy. The results indicate that the vibrational coupling between the stretching modes of the CO and CN ligands is small and restricted to certain modes but the slow ...

We have constructed a 1064 nm deep near-infrared (NIR) excited multichannel Raman microspectrometer using an InP/InGaAsP multichannel detector. This microspectrometer achieves high sensitivity suitable for in vivo measurements of single living cells with lateral resolution of 0.7 μm and depth resolution of 3.1 μm. It has been applied to the ...

Recent works have shown the use of diffusion geometry for various pattern recognition applications, including nonrigid shape analysis. In this paper, we introduce spectral shape distance as a general framework for distribution-based shape similarity and show that two recent methods for shape similarity due to Rustamov and Mahmoudi and Sapiro ...

A solid immersion lens can be applied for high-resolution subsurface analysis of integrated circuits and other physical systems. We present a thorough analysis of the focal field distribution of a solid immersion lens system of arbitrary thickness. Cases of linearly and radially polarized illumination are examined and accurate expressions derived ...