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Musilova S S Department of Microbiology, Nutrition and Dietetics, Faculty of Agrobiology Food and Natural Resources, Czech University of Life Sciences, Kamycka 129, 165 21 Prague 6, Czech - - 2014
Human milk is the gold standard for nourishment of early infants because it contains a number of bioactive components, such as human milk oligosaccharides (HMOs). The high concentration and structural diversity of HMOs are unique to humans. HMOs are a group of complex and diverse glycans that are resistant to ...
Ruhaak L Renee LR Department of Chemistry, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA, - - 2014
Human milk oligosaccharides (HMO) are one of the major components of human milk. HMO are non-digestible by the human gut, where they are known to play important functions as prebiotics and decoys for binding pathogens. Moreover, it has been proposed that HMO may provide sialic acids to the infant that ...
Gallo Sina S School of Dietetics and Human Nutrition, McGill University, Montréal, Québec H9X 3V9, Canada; Nutrition and Food Studies, George Mason University, Fairfax, VA 22030, - - 2014
Few normative data exist for routine clinical chemistry in healthy term infants, that is, during a time of rapid development. Biochemical markers are significantly affected by these physiological changes and the lack of appropriate reference intervals may impede diagnostics in infants. To define reference intervals for calcium, phosphate, creatinine, and ...
Téglás ErnÅ‘ E Cognitive Development Center, Central European University, Budapest, - - 2014
Recent research shows that preverbal infants can reason about single-case probabilities without relying on observed frequencies, adapting their predictions to relevant dynamic parameters of the situation (Téglás, Vul, Girotto, Gonzalez, Tenenbaum & Bonatti, ; Téglás, Girotto, Gonzalez & Bonatti, ). Here we show that intuitions of probabilities may derive from ...
Noori S S Division of Neonatology and the Center for Fetal and Neonatal Medicine, Department of Pediatrics, Children's Hospital Los Angeles and the LAC+USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, - - 2014
Objective:To investigate the effect of targeted neonatal echocardiography (TnEcho) on heart rate, arterial oxygen saturation (SPO2), cerebral regional oxygen saturation (CrSO2) and cerebral fractional oxygen extraction (CFOE) in extremely preterm infants during the first 3 postnatal days.Study Design:As a nested study in a prospective observational study, we acquired continuous data ...
Brownell Elizabeth A EA 1 Connecticut Human Milk Research Center, Division of Neonatology, Connecticut Children's Medical Center, Hartford, - - 2014
Abstract Background: Previous research has not evaluated predictors of donor human milk (DHM) non-consent status in a neonatal intensive care unit (ICU) setting within the United States. The purpose of this study is to identify and describe maternal and infant factors associated with DHM consent status in a Level IV ...
Sorensen Grith Lykke GL Institute of Molecular Medicine, University of Southern Denmark, Odense, - - 2014
Associations between the genetic variation within or downstream of the surfactant protein-D-encoding gene (SFTPD), which encodes the collectin surfactant protein-D (SP-D) and may lead to respiratory distress syndrome or bronchopulmonary dysplasia, recently were reported. Our aim was to investigate whether SFTPD variations affect serum SP-D levels in infants and pulmonary ...
Mazur Mary G MG Mary G. Mazur, BSN, RN, is a Staff Nurse, Providence Hospital, Alternative Birth Care Unit, 16001 W 9 Mile Road, Southfield, MI 48175. She can be reached via e-mail at mayrmazur@gmail.com Judith Mihalko-Mueller, RN, Helen Callans, BS, RN, Deetra Klesh, BSN, RN, Heather Sell, MSN, RN, and Diane Bendig, ASN, RN, are Staff Nurses, Providence Hospital, Alternative Birth Care Unit, 16001 W 9 Mile Road, Southfield, MI - - 2014
To determine the level of agreement between transcutaneous bilirubin (TcB) measurements when sequentially measured by one and two users. A method comparison study design was used to compare two sequential TcB measurements (JM103, Drager Medical Inc., Telford, PA) obtained by the same user and then by two different users. Users ...
Läer K - - 2014
It has been suggested that progressive adenosine triphosphate (ATP) depletion could play a key role in sudden infant death syndrome (SIDS). Because mitochondrial deoxyribonucleic acid (mtDNA) codes for a subset of essential genes for oxidative phosphorylation, we investigated 22 mtDNA polymorphisms in a large sample of Caucasian SIDS cases. A ...
Salomonis Nathan N Department of Pediatrics, Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center Research Foundation, Cincinnati, Oh 45229, - - 2014
Sudden Infant Death Syndrome (SIDS) remains one of the primary causes of infant mortality in developed countries. While the causes of SIDS remain largely inconclusive, some of the most informative associations implicate molecular, genetic, anatomical, physiological and environmental (i.e., infant sleep) factors. Thus, a comprehensive and evolving systems-level model is ...
Greaves Ronda F RF School of Medical Sciences, RMIT University, Victoria, Australia; Murdoch Children's Research Institute, Melbourne, - - 2014
Preterm infants, especially those born very preterm (<32weeks' gestation), suffer a number of morbidities. Immaturity of the endocrine system and its potential impact on morbidity is the subject of numerous studies. Hormone concentrations are sometimes measured in very preterm infants, however there are little normative data available to be able ...
Væver Mette M Department of Psychology, University of Copenhagen, Copenhagen, Denmark, - - 2014
Head orientation in face-to-face interactions between mothers and infants is an important component of their communicative processes. Manual coding, however, is laborious. Obtaining inter-observer reliability is difficult, with disagreements mostly being related to the on- and offsets of a limited number of orientation categories. We used a motion capture system ...
Schriever Valentin A VA Smell and Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, Dresden, - - 2014
To evaluate olfactory event-related potentials (OERPs) as an objective measurement of olfactory function in infants. OERPs to phenylethyl alcohol were measured in 13 infants, between 23 and 41 days of age. The odor was delivered with a computer-controlled olfactometer. Recording electrodes were applied using the 10-20 system. Data from electrodes Fz, ...
Adler Scott A SA 5030 TEL Building, York University, 4700 Keele St., Toronto, ON, M3J 1P3, Canada, - - 2014
Search asymmetry is characterized by the detection of a feature-present target amidst feature-absent distractors being efficient and unaffected by the number of distractors, whereas detection of a feature-absent target amidst feature-present distractors is typically inefficient and affected by the number of distractors. Although studies have attempted to investigate this phenomenon ...
Schneider Anna A Division for Neonatology, University Hospital for Pediatrics, Paracelsus Medical University, Müllner Hauptstraße 48, 5020, Salzburg, - - 2014
Measuring cerebral oxygenation using near-infrared spectroscopy (NIRS) has taken on an increasingly important role in the field of neonatology. Several companies have already developed commercial devices and more publications are reporting absolute boundary values or percentiles for neonates. We compared four commercially used devices to discover whether they provided consistent ...
Gierbolini-Norat Estela M EM Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2014
Feeding is a rhythmic behavior that consists of several component cycle types. How the timing of these cycles changes over a complete feeding sequence is not well known. To test the hypothesis that cycle frequency/duration changes as a function of time spent feeding, we examined complete feeding sequences in six ...
Basirat Anahita A INSERM, U992, Cognitive Neuroimaging Unit, F-91191 Gif/Yvette, France; CEA, DSV/I2BM, NeuroSpin Center, F-91191 Gif/Yvette, France; University Paris-Sud, Cognitive Neuroimaging Unit, F-91191 Gif/Yvette, France. Electronic address: - - 2014
The adult human brain quickly adapts to regular temporal sequences, and emits a sequence of novelty responses when these regularities are violated. These novelty responses have been interpreted as error signals that reflect the difference between the incoming signal and predictions generated at multiple cortical levels. Do infants already possess ...
Brenna J Thomas JT Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA. Electronic address: - - 2014
Humans evolved a uniquely large brain among terrestrial mammals. Brain and nervous tissue is rich in the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA). Docosahexaenoic acid is required for lower and high order functions in humans because of understood and emerging molecular mechanisms. Among brain components that depend on ...
Cuevas Guaman Milenka M Department of Pediatrics, Division of Neonatology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, - - 2014
Background:Respiratory distress syndrome (RDS) persists as a prevalent cause of infant morbidity and mortality. We have previously demonstrated that deletion of Erk3 results in pulmonary immaturity and neonatal lethality. Using RNA-Seq, we identified corticotrophin releasing hormone (CRH) and surfactant protein B (SFTPB) as potential molecular mediators of Erk3-dependent lung maturation. ...
Takahashi Yoshiko Y Department of Pediatrics, Teikyo University Chiba Medical Center, Chiba, Japan; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, - - 2014
Streptococcus gallolyticus subsp. pasteurianus was formerly classified as S. bovis biotype II/2, which is recognized as a rare cause of neonatal sepsis and meningitis. Since the taxonomy classification change, there have not been many reports of meningitis due to S. gallolyticus subsp. pasteurianus. Moreover, the pathogenesis of late onset S. gallolyticus subsp. pasteurianus ...
Lewis Lisa A LA Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, - - 2014
Neisseria meningitidis utilize capsular polysaccharide, lipooligosaccharide (LOS) sialic acid, factor H binding protein (fHbp) and Neisserial surface protein A (NspA) to regulate the alternative pathway (AP) of complement. Using meningococcal mutants that lacked all four above-mentioned molecules (quadruple mutants) we recently identified a role for PorB2 in attenuating the human ...
Mikó-Baráth Eszter E Institute of Physiology, Medical School of Pécs, University of Pécs, 12 Szigeti str., Pécs, H-7623, - - 2014
Purpose: P1 is the major positive component of pattern-reversal visual evoked potentials (PR-VEPs). The rapid decrease of its latency correlates with the progressive myelination in the developing infant brain, which affects signal transmission in the visual system. An age dependent phase shift, analogous to P1 peak latency, can be observed ...
Lazare Farrah B FB *Division of Pediatric Gastroenterology, Hepatology and Nutrition, Winthrop University Hospital, Mineola, NY †Office of Health Outcomes Research, Winthrop University Hospital, Mineola, NY ‡Department of Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, - - 2014
Infants with milk protein intolerance are usually switched to a casein hydrolysate or amino acid based formula, which they continue to receive until one year of age, when they are rechallenged with a cow's milk or soy protein formula. To investigate whether some of these infants actually become tolerant sooner, ...
Chow Jomay - - 2014
Non-targeted metabolomics analyses were used: (1) to compare fecal metabolite profiles of healthy breast-fed (BF) and formula-fed (FF) infants before and during in vitro fermentation in batch culture, and (2) to evaluate fecal metabolomics in assessing infant diet. Samples from healthy BF (n = 4) or FF (n = 4) ...
Burnham Laura L 1The Breastfeeding Center, Division of General Pediatrics, Boston Medical Center, Boston, MA, - - 2014
Background:Infant feeding data are often collected retrospectively through maternal report. Validation studies show that maternal report of initiation and duration of any breastfeeding is accurate but that report of duration of exclusive breastfeeding may be less accurate.Objective:This study aimed to compare infant feeding data collected longitudinally throughout the first 6 ...
Intanon Montira M Food Biotechnology Laboratory, Department of Food Sciences and Technology, BOKU University of Natural Resources and Life Sciences, Vienna, - - 2014
Human milk oligosaccharides are prominent among the functional components of human breast milk. While human milk oligosaccharides have potential applications in both infants and adults, this potential is limited by the difficulties in manufacturing these complex structures. Consequently functional alternatives such as galacto-oligosaccharides are under investigation, and nowadays infant formulae ...
Elabiad Mohamad T MT Division of Neonatology, Department of Pediatrics, University of Tennessee Health Science Center (UTHSC), Memphis, - - 2014
Objective Low total serum protein levels may cause a positive bias on C-reactive protein (CRP) detected by the Vitros 250 Chemistry System (Ortho-Clinical Diagnostics, Inc., Johnson & Johnson Co., Raritan, NJ). Low total serum protein levels are observed in some infants. Our objective was to define a cutoff value for normal ...
Lee Hyeyoung H Department of Food Science and Technology, University of California, Davis, CA, 95616, United States; Foods for Health Institute, University of California, Davis, CA, 95616, United - - 2014
Gangliosides are receiving considerable attention because they participate in diverse biological processes. Milk gangliosides appear to block pathogen adhesion and modify the intestinal ecology of newborns. However, the interaction of milk gangliosides with gut bifidobacteria has been little investigated. The digestion products of a mixture of gangliosides isolated from milk ...
Piantadosi Steven T ST Department of Brain and Cognitive Sciences, University of Rochester, - - 2014
Studies of infant looking times over the past 50 years have provided profound insights about cognitive development, but their dependent measures and analytic techniques are quite limited. In the context of infants' attention to discrete sequential events, we show how a Bayesian data analysis approach can be combined with a rational ...
Gallo Sina S Department of Nutrition and Food Studies, George Mason University, Fairfax, VA, - - 2014
Although no gold standard exists, liquid chromatography tandem mass spectrometry (LC-MS/MS) is a precise and accurate method for the analysis of plasma 25-hydroxyvitamin D (25(OH)D). Immunoassays are more readily available and require small volume sampling, ideal for infant testing. The objective was to compare two commercially available immunoassays for measuring ...
Bernhard Wolfgang W Department of Neonatology, Faculty of Medicine, Eberhard-Karls-University, Calwer Straße 7, 72076, Tübingen, Germany, - - 2014
During fetal development, docosahexaenoic (DHA) and arachidonic acid (ARA) are particularly enriched in brain phospholipids. After preterm delivery, fetal enrichment of DHA and ARA via placental transfer is replaced by enteral and parenteral nutrition, which is rich in linoleic acid (LA) instead. Specific DHA and ARA enrichment of lipoproteins is ...
Chassard Christophe C Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zürich, Schmelzbergstrasse 7, Zürich CH-8092, - - 2014
Initial neonatal gut colonization is a crucial stage for developing a healthy physiology, beneficially influenced by breast-feeding. Breast milk has been shown not only to provide nutrients and bioactive immunological compounds, but also commensal bacteria, including gut-associated anaerobic bacteria such as Bifidobacterium species. Infant formulas are increasingly supplemented with probiotic ...
Lönnerdal Bo B Department of Nutrition, University of California, Davis, Davis, - - 2014
Human milk contains an abundance of biologically active components that are highly likely to contribute to the short- and long-term benefits of breastfeeding. Many of these components are proteins; this article describes some of these proteins, such as α-lactalbumin, lactoferrin, osteopontin, and milk fat globule membrane proteins. The possibility of ...
Granland Caitlyn C School of Veterinary & Life Sciences, Murdoch University, Perth, - - 2014
To evaluate mononuclear cell expression and function of the cytosolic nucleotide-binding oligomerization domain-containing receptors, NOD1 and NOD2, in very preterm and full-term infants. NOD1 and NOD2 gene and protein expression in very preterm infants, term infants and healthy adult, cord and peripheral blood mononuclear cells (C/PBMC) were quantified using qPCR ...
Matsui Mie M Department of Psychology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, - - 2014
Functional near infrared spectroscopy (fNIRS), which is compact, portable, and tolerant of body movement, is suitable for monitoring infant brain functions. Nevertheless, fNIRS also poses a technical problem in that it cannot provide structural information. Supplementation with structural magnetic resonance images (MRI) is not always feasible for infants who undergo ...
Coceani Flavio - - 2014
The ductus arteriosus is a large fetal vessel connecting pulmonary artery with aorta and allowing right ventricular blood to bypass the unexpanded lungs. At birth, with the start of lung ventilation and the attendant rise in blood oxygen tension, the ductus closes and the cardiovascular system acquires its final arrangement. ...
Smilowitz Jennifer T JT 1Department of Food Science and Technology, University of California Davis, Davis, CA, - - 2014
Background:Although it is well established that human milk varies widely in macronutrient content, it remains common for human milk fortification for premature infants to be based on historic mean values. As a result, those caring for premature infants often underestimate protein intake. Rapid precise measurement of human milk protein, fat, ...
Sylvester Karl G KG Division of Pediatric Surgery, Lucile Packard Children's Hospital, Palo Alto, CA; Department of Surgery, Stanford University School of Medicine, Stanford, CA. Electronic address: - - 2014
To test the hypothesis that an exploratory proteomics analysis of urine proteins with subsequent development of validated urine biomarker panels would produce molecular classifiers for both the diagnosis and prognosis of infants with necrotizing enterocolitis (NEC). Urine samples were collected from 119 premature infants (85 NEC, 17 sepsis, 17 control) ...
Yamamoto Mikachi M Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Tokyo, - - 2014
Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been utilized for identification of various microorganisms. Malassezia species, including Malassezia restricta, which is associated with seborrheic dermatitis, has been difficult to identify by traditional means. This study was performed to develop a system for identification of Malassezia species with ...
Brooks Brandon - - 2014
The source inoculum of gastrointestinal tract (GIT) microbes is largely influenced by delivery mode in full-term infants, but these influences may be decoupled in very low birth weight (VLBW, <1,500 g) neonates via conventional broad-spectrum antibiotic treatment. We hypothesize the built environment (BE), specifically room surfaces frequently touched by humans, ...
Christensen Robert D RD Women and Newborns Program, Intermountain Healthcare, and Division of Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, - - 2014
Background: Many cases of severe neonatal hyperbilirubinemia never have the underlying cause of the jaundice clearly identified. Thus they are said to have 'idiopathic' severe neonatal jaundice. However, finding the exact cause, if it is a genetic condition, can enable informed anticipatory guidance regarding future episodes of hemolysis, anemia, or ...
Said Mariam M 1] Division of Neonatology, Children's National Health System, 111 Michigan Avenue NW, Washington, DC; USA [2] Department of Pediatrics, George Washington University School of Medicine, Washington, DC; - - 2014
We used a cost-effective, non-invasive method to obtain high-quality DNA from buccal epithelial-cells (BEC) of premature infants for genomic analysis. DNAs from BEC were obtained from premature infants with gestational age ≤ 36 weeks. Short terminal repeats (STRs) were performed simultaneously on DNA obtained from the buccal swabs and blood ...
Roberts Timothy P L TP Department of Radiology, Lurie Family Foundations MEG Imaging Center, The Children's Hospital of Philadelphia Philadelphia, PA, - - 2014
Background: A major motivation in designing the new infant and child magnetoencephalography (MEG) system described in this manuscript is the premise that electrophysiological signatures (resting activity and evoked responses) may serve as biomarkers of neurodevelopmental disorders, with neuronal abnormalities in conditions such as autism spectrum disorder (ASD) potentially detectable early ...
Austin Sean S Nestlé Research Centre, 1000 Lausanne, - - 2014
Beta-galactooligosaccharides (GOS) are oligosaccharides normally produced industrially by transgalactosylation of lactose. They are also present naturally in the milk of many animals including humans and cows. GOS are thought to be good for health, being potential prebiotic fibres, and are increasingly added to food products. In order to control the ...
de Hevia Maria Dolores MD Université Paris Descartes, Laboratoire Psychologie de la Perception, CNRS, UMR 8158, Paris, France; Cognitive NeuroImaging Unit, NeuroSpin, INSERM, U992, Saclay, - - 2014
While associations between number and space, in the form of a spatially oriented numerical representation, have been extensively reported in human adults, the origins of this phenomenon are still poorly understood. The commonly accepted view is that this number-space association is a product of human invention, with accounts proposing that ...
Knight Jason M JM 1] Department of Electrical Engineering, Texas A&M University, College Station, TX [2] Center for Translational Environmental Health Research, Texas A&M University, College Station, - - 2014
The state and development of the intestinal epithelium is vital for infant health, and increased understanding in this area has been limited by an inability to directly assess epithelial cell biology in the healthy newborn intestine. To that end, we have developed a novel, noninvasive, molecular approach that utilizes next ...
Parsons Christine E CE Section of Child and Adolescent Psychiatry, Department of Psychiatry, University of Oxford Oxford, UK ; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University Aarhus, - - 2014
Sound moves us. Nowhere is this more apparent than in our responses to genuine emotional vocalizations, be they heartfelt distress cries or raucous laughter. Here, we present perceptual ratings and a description of a freely available, large database of natural affective vocal sounds from human infants, adults and domestic animals, ...
Goehring Karen C KC Department of Global Discovery Research, Abbott Nutrition, Columbus, Ohio, United States of - - 2014
It has been hypothesized that human milk oligosaccharides (HMOs) confer systemic health benefits to breastfed infants; however, plausible mechanisms for some effects, such as systemic immunomodulation, require HMOs to access the bloodstream of the developing infant. While small concentrations of HMOs have been detected in the urine of breastfed infants ...
Murali Chaya C Department of Molecular and Human Genetics, Baylor College of Medicine; One Baylor Plaza, MS BCM225, Houston, TX, 77030, - - 2014
Congenital Disorder of Glycosylation type Ig (ALG12-CDG) is part of a group of autosomal recessive conditions caused by deficiency of proteins involved in the assembly of dolichol-oligosaccharides used for protein N-glycosylation. In ALG12-CDG, the enzyme affected is encoded by the ALG12 gene. Affected individuals present clinically with neurodevelopmental delay, growth ...
Shah Divyen K - - 2014
There is emerging recognition of the need for continuous long term electrographic monitoring of the encephalopathic neonate. While full-montage EEG with video remains the gold standard for monitoring, it is limited in application due to the complexity of lead application and specialized interpretation of results. Amplitude integrated EEG (aEEG) is ...
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