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Cuevas Guaman Milenka M Department of Pediatrics, Division of Neonatology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, - - 2014
Background:Respiratory distress syndrome (RDS) persists as a prevalent cause of infant morbidity and mortality. We have previously demonstrated that deletion of Erk3 results in pulmonary immaturity and neonatal lethality. Using RNA-Seq, we identified corticotrophin releasing hormone (CRH) and surfactant protein B (SFTPB) as potential molecular mediators of Erk3-dependent lung maturation. ...
Takahashi Yoshiko Y Department of Pediatrics, Teikyo University Chiba Medical Center, Chiba, Japan; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, - - 2014
Streptococcus gallolyticus subsp. pasteurianus was formerly classified as S. bovis biotype II/2, which is recognized as a rare cause of neonatal sepsis and meningitis. Since the taxonomy classification change, there have not been many reports of meningitis due to S. gallolyticus subsp. pasteurianus. Moreover, the pathogenesis of late onset S. gallolyticus subsp. pasteurianus ...
Lewis Lisa A LA Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, - - 2014
Neisseria meningitidis utilize capsular polysaccharide, lipooligosaccharide (LOS) sialic acid, factor H binding protein (fHbp) and Neisserial surface protein A (NspA) to regulate the alternative pathway (AP) of complement. Using meningococcal mutants that lacked all four above-mentioned molecules (quadruple mutants) we recently identified a role for PorB2 in attenuating the human ...
Mikó-Baráth Eszter E Institute of Physiology, Medical School of Pécs, University of Pécs, 12 Szigeti str., Pécs, H-7623, - - 2014
Purpose: P1 is the major positive component of pattern-reversal visual evoked potentials (PR-VEPs). The rapid decrease of its latency correlates with the progressive myelination in the developing infant brain, which affects signal transmission in the visual system. An age dependent phase shift, analogous to P1 peak latency, can be observed ...
Lazare Farrah B FB *Division of Pediatric Gastroenterology, Hepatology and Nutrition, Winthrop University Hospital, Mineola, NY †Office of Health Outcomes Research, Winthrop University Hospital, Mineola, NY ‡Department of Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, - - 2014
Infants with milk protein intolerance are usually switched to a casein hydrolysate or amino acid based formula, which they continue to receive until one year of age, when they are rechallenged with a cow's milk or soy protein formula. To investigate whether some of these infants actually become tolerant sooner, ...
Chow Jomay - - 2014
Non-targeted metabolomics analyses were used: (1) to compare fecal metabolite profiles of healthy breast-fed (BF) and formula-fed (FF) infants before and during in vitro fermentation in batch culture, and (2) to evaluate fecal metabolomics in assessing infant diet. Samples from healthy BF (n = 4) or FF (n = 4) ...
Burnham Laura L 1The Breastfeeding Center, Division of General Pediatrics, Boston Medical Center, Boston, MA, - - 2014
Background:Infant feeding data are often collected retrospectively through maternal report. Validation studies show that maternal report of initiation and duration of any breastfeeding is accurate but that report of duration of exclusive breastfeeding may be less accurate.Objective:This study aimed to compare infant feeding data collected longitudinally throughout the first 6 ...
Intanon Montira M Food Biotechnology Laboratory, Department of Food Sciences and Technology, BOKU University of Natural Resources and Life Sciences, Vienna, - - 2014
Human milk oligosaccharides are prominent among the functional components of human breast milk. While human milk oligosaccharides have potential applications in both infants and adults, this potential is limited by the difficulties in manufacturing these complex structures. Consequently functional alternatives such as galacto-oligosaccharides are under investigation, and nowadays infant formulae ...
Elabiad Mohamad T MT Division of Neonatology, Department of Pediatrics, University of Tennessee Health Science Center (UTHSC), Memphis, - - 2014
Objective Low total serum protein levels may cause a positive bias on C-reactive protein (CRP) detected by the Vitros 250 Chemistry System (Ortho-Clinical Diagnostics, Inc., Johnson & Johnson Co., Raritan, NJ). Low total serum protein levels are observed in some infants. Our objective was to define a cutoff value for normal ...
Lee Hyeyoung H Department of Food Science and Technology, University of California, Davis, CA, 95616, United States; Foods for Health Institute, University of California, Davis, CA, 95616, United - - 2014
Gangliosides are receiving considerable attention because they participate in diverse biological processes. Milk gangliosides appear to block pathogen adhesion and modify the intestinal ecology of newborns. However, the interaction of milk gangliosides with gut bifidobacteria has been little investigated. The digestion products of a mixture of gangliosides isolated from milk ...
Gallo Sina S Department of Nutrition and Food Studies, George Mason University, Fairfax, VA, - - 2014
Although no gold standard exists, liquid chromatography tandem mass spectrometry (LC-MS/MS) is a precise and accurate method for the analysis of plasma 25-hydroxyvitamin D (25(OH)D). Immunoassays are more readily available and require small volume sampling, ideal for infant testing. The objective was to compare two commercially available immunoassays for measuring ...
Bernhard Wolfgang W Department of Neonatology, Faculty of Medicine, Eberhard-Karls-University, Calwer Straße 7, 72076, Tübingen, Germany, - - 2014
During fetal development, docosahexaenoic (DHA) and arachidonic acid (ARA) are particularly enriched in brain phospholipids. After preterm delivery, fetal enrichment of DHA and ARA via placental transfer is replaced by enteral and parenteral nutrition, which is rich in linoleic acid (LA) instead. Specific DHA and ARA enrichment of lipoproteins is ...
Chassard Christophe C Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zürich, Schmelzbergstrasse 7, Zürich CH-8092, - - 2014
Initial neonatal gut colonization is a crucial stage for developing a healthy physiology, beneficially influenced by breast-feeding. Breast milk has been shown not only to provide nutrients and bioactive immunological compounds, but also commensal bacteria, including gut-associated anaerobic bacteria such as Bifidobacterium species. Infant formulas are increasingly supplemented with probiotic ...
Lönnerdal Bo B Department of Nutrition, University of California, Davis, Davis, - - 2014
Human milk contains an abundance of biologically active components that are highly likely to contribute to the short- and long-term benefits of breastfeeding. Many of these components are proteins; this article describes some of these proteins, such as α-lactalbumin, lactoferrin, osteopontin, and milk fat globule membrane proteins. The possibility of ...
Granland Caitlyn C School of Veterinary & Life Sciences, Murdoch University, Perth, - - 2014
To evaluate mononuclear cell expression and function of the cytosolic nucleotide-binding oligomerization domain-containing receptors, NOD1 and NOD2, in very preterm and full-term infants. NOD1 and NOD2 gene and protein expression in very preterm infants, term infants and healthy adult, cord and peripheral blood mononuclear cells (C/PBMC) were quantified using qPCR ...
Matsui Mie M Department of Psychology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, - - 2014
Functional near infrared spectroscopy (fNIRS), which is compact, portable, and tolerant of body movement, is suitable for monitoring infant brain functions. Nevertheless, fNIRS also poses a technical problem in that it cannot provide structural information. Supplementation with structural magnetic resonance images (MRI) is not always feasible for infants who undergo ...
Coceani Flavio - - 2014
The ductus arteriosus is a large fetal vessel connecting pulmonary artery with aorta and allowing right ventricular blood to bypass the unexpanded lungs. At birth, with the start of lung ventilation and the attendant rise in blood oxygen tension, the ductus closes and the cardiovascular system acquires its final arrangement. ...
Smilowitz Jennifer T JT 1Department of Food Science and Technology, University of California Davis, Davis, CA, - - 2014
Background:Although it is well established that human milk varies widely in macronutrient content, it remains common for human milk fortification for premature infants to be based on historic mean values. As a result, those caring for premature infants often underestimate protein intake. Rapid precise measurement of human milk protein, fat, ...
Sylvester Karl G KG Division of Pediatric Surgery, Lucile Packard Children's Hospital, Palo Alto, CA; Department of Surgery, Stanford University School of Medicine, Stanford, CA. Electronic address: - - 2014
To test the hypothesis that an exploratory proteomics analysis of urine proteins with subsequent development of validated urine biomarker panels would produce molecular classifiers for both the diagnosis and prognosis of infants with necrotizing enterocolitis (NEC). Urine samples were collected from 119 premature infants (85 NEC, 17 sepsis, 17 control) ...
Yamamoto Mikachi M Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Tokyo, - - 2014
Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been utilized for identification of various microorganisms. Malassezia species, including Malassezia restricta, which is associated with seborrheic dermatitis, has been difficult to identify by traditional means. This study was performed to develop a system for identification of Malassezia species with ...
Brooks Brandon - - 2014
The source inoculum of gastrointestinal tract (GIT) microbes is largely influenced by delivery mode in full-term infants, but these influences may be decoupled in very low birth weight (VLBW, <1,500 g) neonates via conventional broad-spectrum antibiotic treatment. We hypothesize the built environment (BE), specifically room surfaces frequently touched by humans, ...
Christensen Robert D RD Women and Newborns Program, Intermountain Healthcare, and Division of Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, - - 2014
Background: Many cases of severe neonatal hyperbilirubinemia never have the underlying cause of the jaundice clearly identified. Thus they are said to have 'idiopathic' severe neonatal jaundice. However, finding the exact cause, if it is a genetic condition, can enable informed anticipatory guidance regarding future episodes of hemolysis, anemia, or ...
Said Mariam M 1] Division of Neonatology, Children's National Health System, 111 Michigan Avenue NW, Washington, DC; USA [2] Department of Pediatrics, George Washington University School of Medicine, Washington, DC; - - 2014
We used a cost-effective, non-invasive method to obtain high-quality DNA from buccal epithelial-cells (BEC) of premature infants for genomic analysis. DNAs from BEC were obtained from premature infants with gestational age ≤ 36 weeks. Short terminal repeats (STRs) were performed simultaneously on DNA obtained from the buccal swabs and blood ...
Roberts Timothy P L TP Department of Radiology, Lurie Family Foundations MEG Imaging Center, The Children's Hospital of Philadelphia Philadelphia, PA, - - 2014
Background: A major motivation in designing the new infant and child magnetoencephalography (MEG) system described in this manuscript is the premise that electrophysiological signatures (resting activity and evoked responses) may serve as biomarkers of neurodevelopmental disorders, with neuronal abnormalities in conditions such as autism spectrum disorder (ASD) potentially detectable early ...
Austin Sean S Nestlé Research Centre, 1000 Lausanne, - - 2014
Beta-galactooligosaccharides (GOS) are oligosaccharides normally produced industrially by transgalactosylation of lactose. They are also present naturally in the milk of many animals including humans and cows. GOS are thought to be good for health, being potential prebiotic fibres, and are increasingly added to food products. In order to control the ...
Lu Y Y Key Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University, Harbin 150030, China; National Dairy Engineering and Technical Research Center, Harbin 150086, - - 2013
Cronobacter species represent an emerging opportunistic foodborne pathogen associated with meningitis and necrotizing enterocolitis in infants. Current evidence indicates that powdered infant formula (PIF) is the main source of Cronobacter contamination. A total of 75 strains of Cronobacter spp. from different geographic regions, as well as from PIF processing environments, ...
Nandyal Raja R University of Oklahoma Health Sciences Center, Oklahoma, - - 2013
Late preterm infants (LPI) are preterm infants born at a gestational age between 34 and 0/7 weeks to 36 6/7 weeks. Because of their physiologic and metabolic immaturities, they are at increased risk for a spectrum of morbidities and mortality when compared to the term infants. LPI are "great pretenders ...
Kaatiala Jussi - - 2013
Recording of event-related potentials (ERPs) is one of the best-suited technologies for examining brain function in human infants. Yet the existing software packages are not optimized for the unique requirements of analyzing artifact-prone ERP data from infants. We developed a new graphical user interface that enables an efficient implementation of ...
Morzel M - - 2013
Based on recent studies in adult subjects, saliva composition is increasingly considered as a physiological factor contributing to taste sensitivity or acceptance. In order to evaluate a possible link between salivary protein composition and taste acceptance in infants, 73 infants participated longitudinally in taste acceptance tests and donated saliva at ...
Dotz Viktoria - - 2013
Human milk oligosaccharides (HMO) have been paid much attention due to their beneficial effects observed in vitro, e.g. prebiotic, anti-infective, and anti-inflammatory properties. However, in vivo investigations with regard to HMO metabolism and functions are rare. The few data available indicate that HMO are absorbed to a low extent and ...
Moffett Elizabeth A EA Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, One Hospital Drive, Columbia, - - 2014
The anterior fontanelle (AF) is an integral element of the developing human infant craniofacial system. Consideration of the AF is crucial for assessing craniofacial growth, as altered development of this feature may indicate abnormal growth. Moreover, prolonged patency of the AF may represent a derived hominin feature. The AF is ...
Chen Tianyan - - 2013
Neither HBV DNA nor HBsAg positivity at birth is an accurate marker for HBV infection of infants. No data is available for continuous changes of HBV markers in newborns to HBsAg(+) mothers. This prospective, multi-centers study aims at observing the dynamic changes of HBV markers and exploring an early diagnostic ...
Sharifzadeh Mohsen - - 2013
ABSTRACT. We have developed a reflection-based capability of the RetCam® platform, an FDA-cleared pediatric retinal-imaging instrument, for the purpose of measuring macular pigment levels as well as their spatial distributions in infants and children. Our modifications include narrow-band blue-wavelength excitation of the macular pigment absorption in combination with spectrally selective ...
Tesfai Adiam - - 2014
Infant milk formula has recently been implicated as a transmission vehicle for an emerging foodborne pathogen, Enterobacter sakazakii, resulting in high mortality rates. Electron beam (e-beam) efficiently and non-thermally inactivates foodborne pathogens, including E. sakazakii, in infant milk formula. However, the effects of e-beam on chemical changes of nutrients in ...
Hirshkowitz Amy - - 2013
Our capacity to perceive three-dimensional (3D) object structure from two-dimensional (2D) retinal input is fundamental to object perception. The present research examined infants' ability to extract 3D form from structure-from-motion (SFM) displays using a familiarization/visual-paired-comparison paradigm. In SFM displays dots are projected onto the surfaces of a shape that rotates ...
Quinn Elizabeth A - - 2013
Recently, there has been considerable debate regarding the appropriate amount of iron fortification for commercial infant formula. Globally, there is considerable variation in formula iron content, from 4 to 12 mg iron/L. However, how much fortification is necessary is unclear. Human milk is low in iron (0.2-0.5 mg/L), with the ...
Raikos Vassilios V Rowett Institute of Nutrition & Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB - - 2014
Milk proteins have attracted extensive interest in terms of their bioavailability following ingestion. Enzymatic digestion of dairy products generates numerous peptides with various biological activities. Both human milk and infant formulas based on cow's milk are potential sources of bioactive peptides. This review aims to present current knowledge on the ...
Govindan Rathinaswamy B - - 2013
In order to mitigate the effect of non-stationarity in frequency domain analysis of data, we propose a modification to the power spectral estimation, a widely used technique to characterize physiological signals. Spectral analysis requires partitioning data into smaller epochs determined by the desired frequency resolution. The modified approach proposed here ...
Sharma Shilpa S Post Graduate Institute of Medical Education and Research, Dr. Ram ManoharLohia Hospital, New Delhi, India ; Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, - - 2013
Duodenal stenosis usually occurs in isolation and has a variable presentation in infancy due to partial obstruction. An unusual case of congenital double duodenal diaphragms in an infant presenting as failure to thrive has been described and pertinent literature has been reviewed herein. Excision of webs with double Heineke-Mikulicz closure ...
Romek Katarzyna M - - 2013
Since exclusively breast-suckled infants obtain their nutrient only from their mother's milk, it might be anticipated that a correlation will exist between the (15)N/(14)N isotope ratios of amino acids of protein of young infants and those supplied by their mother. The work presented here aimed to determine whether amino nitrogen ...
Mecchia Donatella - - 2013
We present a case of sudden death of a 1-month-old male infant with heart, brainstem and genetic polymorphism involvement. Previously considered quite healthy, the child died suddenly and unexpectedly during sleep. The autopsy protocol included an in-depth anatomopathological examination of both the autonomic nervous system and the cardiac conduction system, ...
Ménard Olivia - - 2014
Understanding the mechanisms of infant formula disintegration in the infant gastrointestinal tract is a key step for developing new formulas with health benefits for the neonate. For ethical reasons, the access to in vivo data obtained on infants is limited. The use of animal models can be an alternative but ...
Ifflaender Sascha - - 2013
Due to a rising number of head deformities in healthy newborns, there has been an increasing interest in nonsynostotic head deformities in children over recent years. Although preterm infants are more likely to have anomalous head shapes than term newborns, there is limited data available on early prevalence of head ...
Moore Gregory P - - 2013
IMPORTANCE Many centers delivering infants at 22 to 25 weeks' gestation have limited data regarding their outcomes. A meta-analysis of the 4- to 8-year neurodevelopmental outcomes and exploration of the limitations of meta-analysis would aid physicians and parents to plan care for these infants. OBJECTIVES To determine the rate of ...
de Betue Carlijn Ti - - 2013
Arginine is considered an essential amino acid during critical illness in children, and supplementation of arginine has been proposed to improve arginine availability to facilitate nitric oxide (NO) synthesis. Protein-energy-enriched enteral formulas (PE-formulas) can improve nutrient intake and promote anabolism in critically ill infants. However, the effect of increased protein ...
Gram Magnus - - 2013
Cerebral intraventricular hemorrhage (IVH) is a major cause of severe neurodevelopmental impairment in preterm infants. To date, no therapy is available that prevents infants from developing serious neurological disability following IVH. Thus, to develop treatment strategies for IVH, it is essential to characterize the initial sequence of molecular events that ...
Stewart Adam Michael - - 2013
The evolution of the autonomic nervous system provides an organizing principle to interpret the adaptive significance of physiological systems in promoting social behavior and responding to social challenges. This phylogenetic shift in neural regulation of the autonomic nervous system in mammals has produced a neuroanatomically integrated social engagement system, including ...
Dobbins Sara E SE Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, - - 2013
Over 90% of infants (< 1-year-old) diagnosed with leukemia have pro-B acute lymphoblastic leukemia (ALL) containing the MLL-AF4 fusion. When compared with other forms of paediatric ALL affecting later B-cell differentiation, MLL-AF4 pro-B is associated with a dismal prognosis with a typical 5-year disease-free survival of <20%. MLL-AF4 may be ...
Brown Angela M - - 2013
Almost 40 years ago, Davida Teller developed the forced-choice preferential looking method for studying infant visual capabilities and used it to study infant color vision. About 10 years ago, she used infant looking preferences to study infant color perception. Here, we examine four data sets in which the infant looking ...
Ntoumani E - - 2013
Nervonic acid is important for white matter development and its incorporation increases rapidly in the last trimester, but few studies focus on this fatty acid. Other mother's milk, usually after term delivery, is often used for premature infants, whose mothers cannot breastfeed. The fatty acid (FA) concentrations were analyzed by ...
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