Of concern to new mothers is often the question, "Does my baby look normal?" In regard to the scalp and hair patterns of the infant, we have provided at least a basic guideline of what is generally considered the norm or variants of normal. Our goal was to outline accepted ...

A sample of mothers who had used crack cocaine while pregnant was evaluated during the postpartum period before random assignment to drug treatment. Mean infant age was 74 days. Paired hair samples were acquired from 63 mothers and 63 infants. Maternal urine was screened for cocaine and benzoylecgonine; three different ...

Haematological and serum biochemical measurements were carried out in 1-year-old hairless and haired hybrids derived from the Mexican hairless dog (MHD). These hybrids included F1 hybrids obtained from male MHD and female Beagles, and BCF1 hybrids obtained from male hairless F1 and female Beagles. There were no significant differences between ...

We studied the sensitivity of testing the newborn infant's hair, meconium, and urine in detecting gestational cocaine exposure. The infants were born to 59 women who were interviewed to determine their use of cocaine during pregnancy and whose hair was analyzed for the presence of cocaine. Regression analysis was used ...

The adult rat pineal gland contains relatively high concentrations of Gsa, low amounts of both Gia and Goa, and undetectable levels of GTa. During development the amounts of 45 kDa Gsa and of Gia remain constant. In contrast, 42 kDa Gsa and Goa are nearly absent at birth and increase ...

A rare case of multiple keratoacanthoma in a 9 months old female is reported. It appeared at the age of 1 month. Her mother had been suffering from atopic dermatitis. Hertwo elder brothers and fatherwere normal. Histopathology revealed hypertrophy and dilatation of hair follicles associated with hyperkeratosis papillomatosis, mononuclear infiltration ...

We report a male infant with Menkes' disease who showed, at the age of 3 months, slow growth, hair abnormalities such as pili torti and white hair, and low levels of serum copper and ceruloplasmin. The exceptionally bright portions of his hair contained eumelanin and pheomelanin at levels only half ...

Emulsifiable concentrate and microencapsulated formulations of permethrin were evaluated for residual activity against stable flies on lactating dairy cows. Cows were treated in the field with each formulation and hair was clipped from the leg and shoulder area, and bioassayed at 1, 2, 3, 4, 7 and 14 days after ...

Hair zinc concentration was measured in samples taken from 57 mothers who delivered infants with neural tube defects (NTD) (mainly anencephaly). Control groups consisted of 30 healthy mothers with normal offspring and 37 nonpregnant women from middle-income backgrounds. Zinc concentration was also measured in the hair of eight infants with ...

We describe a Danish family of four generations suffering from hypotrichosis of the scalp. Age at onset was 6-17 years and almost total scalp alopecia was reached by the age of 14-21 years. No associated ectodermal defects were present. Nine of 22 persons covering four generations were affected. Growth of ...

Multimalformed infants (MMI) without a diagnosis of a specific syndrome have often been successfully used by alert clinicians to prompt studies which have led to the definition of new teratogens. However, usually they are not analyzed in any specific way in the routine monitoring by birth defects registries. In 1980 ...

Human foetal adrenal plays a major role in the synthesis and secretion of steroids which are essential to several physiological events during foetal development. Since 3 beta-hydroxysteroid dehydrogenase 5-ene-4-ene isomerase (3 beta-HSD) is involved in the biosynthesis of all classes of hormonal steroids, namely progesterone, glucocorticoids, mineralocorticoids, androgens and estrogens, ...

The earliest stages of acne keloidalis are not well characterized. In the present study, transverse sections of the early lesions revealed follicular units in several stages of inflammation. These follicles surrounded the central follicular units that gave rise to the clinically evident papule. Despite a spectrum of inflammatory changes, the ...

Index by subject of all manuscripts published by the Journal from July 1989 through June 1990.

In vivo and in vitro effects of porphyrins (tin-protoporphyrin [SnPP], cobalt-mesoporphyrin, haemin and protoporphyrin) on neonatal rats were investigated. Under photoirradiation a high mortality rate was recognized in SnPP injected rats. None died from the application of SnPP without photoirradiation. In photoirradiated rats the median lethal dose (LD50) value of ...

Drug self-reports are often unreliable and standard blood and urine tests detect only recent cocaine use. Since cocaine is deposited in hair, we have applied a radioimmunoassay to hair extract to detect past cocaine use. Hair from 16 adult users was positive for benzoylecgonine, in the presence of negative findings ...

Two female cousins were found to be affected with severe retinal dystrophy characterised by visual impairment from birth and profound photophobia in the absence of night blindness. Minimal fundus changes with a small foveal atrophy in the older cousin and slight macular pigment epithelial changes suggestive of early bull's eye ...

Alz-50 is a monoclonal antibody that recognizes pathological alterations in Alzheimer's disease. It has recently been noted also to mark some subplate neurons in human infants under the age of 2 years. We now report that Alz-50 recognizes many neurons in the normal neonatal rat in a pattern that changes ...

Somatostatin (SS)-containing neurons were mapped in the normal infant hypothalamus with immunohistochemistry, using the peroxidase anti-peroxidase technique. Neurons displaying SS immunoreactivity show a widespread distribution throughout the hypothalamic region. Principal SS-immunoreactive like (SS-IL) perikarya are located in the paraventricular, infundibular and posterior nuclei and in the preoptic region. High SS ...

1. Zinc concentration was measured in hair samples from 57 infants (27 boys and 30 girls) aged 7 to 24 months. Twenty-eight infants were considered eutrophic and 29 presented chronic and severe malnutrition. 2. Hair segments less than 3-cm long were cut close to the scalp in the occipital area ...

A gravid female Mermis nigrescens Dujardin (Mermithidae: Nematoda) was recovered from the mouth of a 1-month-old infant in Mehama, Oregon. This nematode is a parasite of grasshoppers and deposits its eggs on vegetation. The parasite was probably carried on the hair of the household dog or cat to the vicinity ...

The activities of glutaminase and glutamate dehydrogenase in the small intestinal mucosa of infant rats were found to increase at the time of weaning. Pyruvate carboxylase activity, on the other hand, was very high during the suckling period and decreased to negligible values at weaning. It is suggested that gluconeogenesis ...

The intestinal mucosa of infant rats was found to produce ketones when incubated in Krebs-Ringer-Bicarbonate solution. No production was found in weaned rats. Ketogenesis could be inhibited by D-carnitine or tetradecylglycidic acid (TDGA) an inhibitor of long-chain acylcarnitine transferase, suggesting that ketone production is due to a large extent to ...

A term infant underwent scalp blood sampling just prior to delivery because of fetal tachycardia. Afterward, a portion of the scalp blade tip was missing and was noted in two fragments on x-ray film. Because of concern about the difficulty of removal, the fragments were left in situ. The infant ...

Although a specific etiology remains undetermined, most evidence points to an autoimmune pathogenesis for alopecia areata. Treatments for alopecia areata are likely to remain palliative until its etiology is better understood. Even it prolonged remissions cannot always be achieved with the treatments presently available, preservation of hair regrowth with maintenance ...

We report on 11 cases of isochromosome 12p mosaicism (or Pallister mosaic aneuploidy syndrome) in which the isochromosome is usually absent in cultured lymphocytes but present in fibroblasts. The patients range in age from a 22-week-gestation fetus to a 45-year-old man. They have a distinct pattern of anomalies which enables ...

Total mercury levels (TML) were determined in 141 samples of maternal head and pubic hair and neonatal scalp hair. The mean mercury contents of maternal head and pubic hair were 1.88 and 1.10 mg kg-1, respectively, while the mean TML of neonatal hair was 0.11 mg kg-1. A statistically significant ...

Hair samples from newborn heifer calves on Holstein dairy farms in southwestern Ontario were analyzed for selenium content by means of instrumental neutron activation analysis. The mean selenium level in the hair of calves which subsequently died at less than six weeks of age did not differ from selenium levels ...

The development of vestibular receptor surfaces was studied during the postnatal period in the rat on the 1st, 7th, 13th, 32nd and 75th days after birth. Cristae and utricles increase and change their shapes, up to day 13 for the cristae and day 32 for the utricles. Cristae hair bundles ...

The mercury content in hair of the population in Madrid (chosen randomly) was in the range of 1.29-129.47 micrograms/g (geometric mean = 7.96 micrograms/g). The mean mercury content in hair of occupationally exposed workers was 12.70 micrograms/g (range = 2.91-65.43 micrograms/g). The highest means, which were found in two families ...

Three children are reported with uncombable hair syndrome, consisting of slow-growing, straw-colored scalp hair that could not be combed flat. The hairs appeared normal on light microscopy but on scanning electron microscopy were triangular in cross section, with canal-like longitudinal depressions. Oral biotin, 0.3 mg three times a day, produced ...

Hair zinc concentration was determined by atomic absorption spectrophotometry in 308 normal newborn infants and 199 normal infants aged one to twelve months. Hair zinc concentration declined from 204 micrograms/gm at birth to 112 micrograms/gm at age eight months, and then rose to 144 micrograms/gm at age twelve months. Diaper ...

Neutron activation analysis was used to determine the distribution of trace elements in human hair. Hair samples were obtained from five infants (two to seven years of age) with hair length ranging from 15 to 40 cm. The hairs were divided into segments, each of 2.5 cm, starting from the ...

The recognition of Menkes' kinky hair syndrome, trichopoliodystrophy, may present problems in the early neonatal period. The serum copper, and ceruloplasmin levels are within the range of normal infants in the first week of life; they are higher than normal in the cord blood of affected infants and fall gradually. ...

Two men at the age of 48 and 54 yr developed gynecomastia and lost their potency after the use of estrogen containing hair lotions. During exposure to the lotion the levels of 17-beta estradiol were increased, whereas the levels of testosterone and gonadotropins were depressed. Thus, a previous application of ...

In the hair of 41 normal newborn children the amounts of the trace elements zinc, copper, manganese and gold were followed up longitudinally by neutron activation analysis, the samples being taken on the 1st day of life, between the 63th and 109th days, the 200th and 240 th as well ...

Clay eating, a form of geophagia, is often observed in the human population, particularly during pregnancy. The intent of this study was to determine the effects of maternal geophagia on developmental and behavioral characteristics of the offspring. Twelve Sprague-Dawley female rats and their 88 progeny were divided into three groups: ...

In order to examine the receptor basis for the development of spontaneous locomotion and for the effects of clonidine in the infant rat, we measured the densities of alpha 1-adrenoceptors, alpha 2-adrenoceptors and D2-dopamine receptors in various brain regions of the developing infant Wistar rat. The mesolimbic D2-dopamine receptors paralleled ...

Two different hybrid myosins were obtained by combining "desensitized" myosin (DM) of Akazara scallop striated adductor with rabbit skeletal DTNB-light chains (DTNB-LC) and with chicken gizzard regulatory light chains (GR-LC). Using the two hybrid myosins, the following were found: (a) DTNB-LC has an inhibitory effect on the Mg-ATPase activities of ...

Several studies suggest that infant animals may be more sensitive to toxic insult from methylmercury than adults. In our experiment, newly born infant monkeys were given equivalent daily doses of 50 micrograms Hg/kg body weight orally in the form of methylmercury for more than 60 weeks. Data revealed that after ...

The concentration of manganese in the hair of normal newborn infants was found to increase significantly from 0.19 micrograms/g at birth to 0.965 micrograms/g at 6 weeks of age and 0.685 micrograms/g at 4 months when they were fed infant formula. There was an insignificant increase to 0.330 micrograms/g at ...

Rats received either control saline, 6-hydroxydopamine (6-OHDA) or kainic acid (KA) unilateral lesions of 5 different foci in the neostriatum. Both KA and 6-OHDA lesions in the mid-ventral focus resulted in a substantial and prolonged impairment in sensorimotor orientation to contralateral stimuli. At all other placements 6-OHDA induced a temporary ...

Acid extracts of human neurohypophyseal tissue were found to contain neurophysin-immunoreactive proteins in the 17,000-20,000 dalton molecular weight range by sodium dodecyl sulfate polyacrylamide gel electrophoresis. The 17,000-20,000 dalton neurophysins persisted under reducing conditions. Limited chymotrypsin proteolysis of the 17,000-20,000 dalton neurophysins generated both increased 10,000 dalton neurophysin and also ...

The effects of prenatal malnutrition on the growth of incisor and molar tooth germs and tongue were investigated in newborn rats. Compared with the results on the young of well-nourished mothers, the young of the malnourished animals had fewer and smaller cells in the molar tooth germs and fewer cells ...

Taxol has the following effects on myogenic cultures: (a) it blocks cell replication of presumptive myoblasts and fibroblasts. (b) It induces the aggregation of microtubules into sheets or massive cables in presumptive myoblasts and fibroblasts, but not in postmitotic, mononucleated myoblasts. (c) It induces normally elongated postmitotic myoblasts to form ...

The roots of Rauwolfia volkensii yielded 26 alkaloids comprising five main groups--sarpagan, akuammicine, heteroyohimbine with derived oxindole and anhydronium bases, yohimbine with 18-hydroxy-yohimbine and its derived esters, and dihydroindole alkaloids. The principal alkaloids were ajmaline (0.08 per cent) and reserpiline (0.15 per cent), and the reserpine yield (0.0007 per cent) ...

The case of a female infant with athelia is reported. Her mother, maternal aunt and grandmother show hypodontia, sparse hair and small breasts associated with mammillary hypoplasia. The clinical features and the results of MINOR's sweat test suggest a heterozygous state of anhidrotic ectodermal dysplasia as the most likely explanation.

After 7 day dosing with SK & F 64139, an inhibitor of adrenal and CNS PNMT, a stoichiometric relationship is observed between epinephrine decrease and norepinephrine increase in adrenal tissue. However, this relationship is not found with the adrenal PNMT inhibitor, SK & F 29661. SK & F 64139 was ...

To clarify the mechanism responsible for age-related differences in tolerance to digitalis, we studied the potassium contents of serum and myocardium and the digoxin concentrations of serum, myocardium, and myocardial microsomal fraction in infant and adult rats. While serum potassium concentration was the same in both infant and adult rats, ...

Hair zinc concentration was measured in centimeter sections of hair strands obtained from 17 mothers after delivery of newborn infants with spina bifida cystica. Thirty unselected healthy mothers and their normal newborn infants served as the controls. In the mothers of the diagnosis group, mean hair zinc concentration (216.2 microgram/g; ...