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Murali Chaya C Department of Molecular and Human Genetics, Baylor College of Medicine; One Baylor Plaza, MS BCM225, Houston, TX, 77030, - - 2014
Congenital Disorder of Glycosylation type Ig (ALG12-CDG) is part of a group of autosomal recessive conditions caused by deficiency of proteins involved in the assembly of dolichol-oligosaccharides used for protein N-glycosylation. In ALG12-CDG, the enzyme affected is encoded by the ALG12 gene. Affected individuals present clinically with neurodevelopmental delay, growth ...
Shah Divyen K - - 2014
There is emerging recognition of the need for continuous long term electrographic monitoring of the encephalopathic neonate. While full-montage EEG with video remains the gold standard for monitoring, it is limited in application due to the complexity of lead application and specialized interpretation of results. Amplitude integrated EEG (aEEG) is ...
Roberts Timothy P L TP Department of Radiology, Lurie Family Foundations MEG Imaging Center, The Children's Hospital of Philadelphia Philadelphia, PA, - - 2014
A major motivation in designing the new infant and child magnetoencephalography (MEG) system described in this manuscript is the premise that electrophysiological signatures (resting activity and evoked responses) may serve as biomarkers of neurodevelopmental disorders, with neuronal abnormalities in conditions such as autism spectrum disorder (ASD) potentially detectable early in ...
Pightling Arthur W AW Listeriosis Reference Service, Research Division, Bureau of Microbial Hazards, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, - - 2014
Cronobacter sakazakii is a food-borne pathogenic bacterium that may cause severe illness in neonates and the elderly. We present the genome sequence of a rare strain (ST40, CC45), commonly found in multiple food processing facilities and in powdered infant formula and only indicted in a single clinical case.
Lu Y Y Key Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University, Harbin 150030, China; National Dairy Engineering and Technical Research Center, Harbin 150086, - - 2013
Cronobacter species represent an emerging opportunistic foodborne pathogen associated with meningitis and necrotizing enterocolitis in infants. Current evidence indicates that powdered infant formula (PIF) is the main source of Cronobacter contamination. A total of 75 strains of Cronobacter spp. from different geographic regions, as well as from PIF processing environments, ...
Nandyal Raja R University of Oklahoma Health Sciences Center, Oklahoma, - - 2013
Late preterm infants (LPI) are preterm infants born at a gestational age between 34 and 0/7 weeks to 36 6/7 weeks. Because of their physiologic and metabolic immaturities, they are at increased risk for a spectrum of morbidities and mortality when compared to the term infants. LPI are "great pretenders ...
Kaatiala Jussi - - 2013
Recording of event-related potentials (ERPs) is one of the best-suited technologies for examining brain function in human infants. Yet the existing software packages are not optimized for the unique requirements of analyzing artifact-prone ERP data from infants. We developed a new graphical user interface that enables an efficient implementation of ...
Morzel M - - 2013
Based on recent studies in adult subjects, saliva composition is increasingly considered as a physiological factor contributing to taste sensitivity or acceptance. In order to evaluate a possible link between salivary protein composition and taste acceptance in infants, 73 infants participated longitudinally in taste acceptance tests and donated saliva at ...
Dotz Viktoria - - 2013
Human milk oligosaccharides (HMO) have been paid much attention due to their beneficial effects observed in vitro, e.g. prebiotic, anti-infective, and anti-inflammatory properties. However, in vivo investigations with regard to HMO metabolism and functions are rare. The few data available indicate that HMO are absorbed to a low extent and ...
Moffett Elizabeth A EA Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, One Hospital Drive, Columbia, - - 2014
The anterior fontanelle (AF) is an integral element of the developing human infant craniofacial system. Consideration of the AF is crucial for assessing craniofacial growth, as altered development of this feature may indicate abnormal growth. Moreover, prolonged patency of the AF may represent a derived hominin feature. The AF is ...
Chen Tianyan - - 2013
Neither HBV DNA nor HBsAg positivity at birth is an accurate marker for HBV infection of infants. No data is available for continuous changes of HBV markers in newborns to HBsAg(+) mothers. This prospective, multi-centers study aims at observing the dynamic changes of HBV markers and exploring an early diagnostic ...
Tesfai Adiam - - 2014
Infant milk formula has recently been implicated as a transmission vehicle for an emerging foodborne pathogen, Enterobacter sakazakii, resulting in high mortality rates. Electron beam (e-beam) efficiently and non-thermally inactivates foodborne pathogens, including E. sakazakii, in infant milk formula. However, the effects of e-beam on chemical changes of nutrients in ...
Sharifzadeh Mohsen M University of Utah, Department of Physics and Astronomy, Salt Lake City, Utah - - 2013
We have developed a reflection-based capability of the RetCam(®) platform, an FDA-cleared pediatric retinal-imaging instrument, for the purpose of measuring macular pigment levels as well as their spatial distributions in infants and children. Our modifications include narrow-band blue-wavelength excitation of the macular pigment absorption in combination with spectrally selective blue-wavelength ...
Hirshkowitz Amy - - 2013
Our capacity to perceive three-dimensional (3D) object structure from two-dimensional (2D) retinal input is fundamental to object perception. The present research examined infants' ability to extract 3D form from structure-from-motion (SFM) displays using a familiarization/visual-paired-comparison paradigm. In SFM displays dots are projected onto the surfaces of a shape that rotates ...
Quinn Elizabeth A - - 2013
Recently, there has been considerable debate regarding the appropriate amount of iron fortification for commercial infant formula. Globally, there is considerable variation in formula iron content, from 4 to 12 mg iron/L. However, how much fortification is necessary is unclear. Human milk is low in iron (0.2-0.5 mg/L), with the ...
Raikos Vassilios V Rowett Institute of Nutrition & Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB - - 2014
Milk proteins have attracted extensive interest in terms of their bioavailability following ingestion. Enzymatic digestion of dairy products generates numerous peptides with various biological activities. Both human milk and infant formulas based on cow's milk are potential sources of bioactive peptides. This review aims to present current knowledge on the ...
Govindan Rathinaswamy B - - 2013
In order to mitigate the effect of non-stationarity in frequency domain analysis of data, we propose a modification to the power spectral estimation, a widely used technique to characterize physiological signals. Spectral analysis requires partitioning data into smaller epochs determined by the desired frequency resolution. The modified approach proposed here ...
Sharma Shilpa S Post Graduate Institute of Medical Education and Research, Dr. Ram ManoharLohia Hospital, New Delhi, India ; Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, - - 2013
Duodenal stenosis usually occurs in isolation and has a variable presentation in infancy due to partial obstruction. An unusual case of congenital double duodenal diaphragms in an infant presenting as failure to thrive has been described and pertinent literature has been reviewed herein. Excision of webs with double Heineke-Mikulicz closure ...
Romek Katarzyna M - - 2013
Since exclusively breast-suckled infants obtain their nutrient only from their mother's milk, it might be anticipated that a correlation will exist between the (15)N/(14)N isotope ratios of amino acids of protein of young infants and those supplied by their mother. The work presented here aimed to determine whether amino nitrogen ...
Mecchia Donatella - - 2013
We present a case of sudden death of a 1-month-old male infant with heart, brainstem and genetic polymorphism involvement. Previously considered quite healthy, the child died suddenly and unexpectedly during sleep. The autopsy protocol included an in-depth anatomopathological examination of both the autonomic nervous system and the cardiac conduction system, ...
Ménard Olivia - - 2014
Understanding the mechanisms of infant formula disintegration in the infant gastrointestinal tract is a key step for developing new formulas with health benefits for the neonate. For ethical reasons, the access to in vivo data obtained on infants is limited. The use of animal models can be an alternative but ...
Ifflaender Sascha - - 2013
Due to a rising number of head deformities in healthy newborns, there has been an increasing interest in nonsynostotic head deformities in children over recent years. Although preterm infants are more likely to have anomalous head shapes than term newborns, there is limited data available on early prevalence of head ...
Moore Gregory P - - 2013
IMPORTANCE Many centers delivering infants at 22 to 25 weeks' gestation have limited data regarding their outcomes. A meta-analysis of the 4- to 8-year neurodevelopmental outcomes and exploration of the limitations of meta-analysis would aid physicians and parents to plan care for these infants. OBJECTIVES To determine the rate of ...
de Betue Carlijn Ti - - 2013
Arginine is considered an essential amino acid during critical illness in children, and supplementation of arginine has been proposed to improve arginine availability to facilitate nitric oxide (NO) synthesis. Protein-energy-enriched enteral formulas (PE-formulas) can improve nutrient intake and promote anabolism in critically ill infants. However, the effect of increased protein ...
Gram Magnus - - 2013
Cerebral intraventricular hemorrhage (IVH) is a major cause of severe neurodevelopmental impairment in preterm infants. To date, no therapy is available that prevents infants from developing serious neurological disability following IVH. Thus, to develop treatment strategies for IVH, it is essential to characterize the initial sequence of molecular events that ...
Stewart Adam Michael AM Brain-Body Center, Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Ave., Chicago, IL 60612, - - 2013
The evolution of the autonomic nervous system provides an organizing principle to interpret the adaptive significance of physiological systems in promoting social behavior and responding to social challenges. This phylogenetic shift in neural regulation of the autonomic nervous system in mammals has produced a neuroanatomically integrated social engagement system, including ...
Dobbins Sara E SE Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, - - 2013
Over 90% of infants (< 1-year-old) diagnosed with leukemia have pro-B acute lymphoblastic leukemia (ALL) containing the MLL-AF4 fusion. When compared with other forms of paediatric ALL affecting later B-cell differentiation, MLL-AF4 pro-B is associated with a dismal prognosis with a typical 5-year disease-free survival of <20%. MLL-AF4 may be ...
Brown Angela M - - 2013
Almost 40 years ago, Davida Teller developed the forced-choice preferential looking method for studying infant visual capabilities and used it to study infant color vision. About 10 years ago, she used infant looking preferences to study infant color perception. Here, we examine four data sets in which the infant looking ...
Ntoumani E - - 2013
Nervonic acid is important for white matter development and its incorporation increases rapidly in the last trimester, but few studies focus on this fatty acid. Other mother's milk, usually after term delivery, is often used for premature infants, whose mothers cannot breastfeed. The fatty acid (FA) concentrations were analyzed by ...
Bamber Andrew R - - 2013
This study aimed to investigate the incidence, and underlying associations, of myocardial necrosis occurring in infants undergoing autopsy. An autopsy database containing anonymized details of all infant autopsies conducted at Great Ormond Street Hospital between January 1996 and December 2010 was searched to identify all infants with myocardial necrosis. The ...
Aqil Mansoor - - 2013
We report a case of unexpected kinking of endotracheal (ET) tube in an infant who was being operated in supine position and positioned away from the anesthetist. The usual management mentioned in the literature was unsuccessful. So, a simple and unique solution that can be useful in unanticipated kinking of ...
Lee Yee Siong - - 2013
This paper further investigates the use of Doppler radar for detecting and identifying certain human respiratory characteristics from observed frequency and phase modulations. Specifically, we show how breathing frequencies can be determined from the demodulated signal leading to identifying abnormalities of breathing patterns using signal derivatives, optimal filtering and standard ...
Neuschulz J - - 2013
In order to visualize and quantify the direction and extent of morphological upper-jaw changes in infants with unilateral cleft lip and palate (UCLP) during early orthodontic treatment, a three-dimensional method of cast analysis for routine application was developed. In the present investigation, this method was used to identify reaction patterns ...
Reggiannini Brian - - 2013
PURPOSE: In this paper, we describe and validate the performance of a modern acoustic analyzer specifically designed for infant-cry analysis. METHOD: Utilizing known algorithms, we developed a method to extract acoustic parameters describing infant cries from standard digital audio files. We use a frame rate of 25 ms with a ...
Cantrell Lisa - - 2013
Considerable research has investigated infants' numerical capacities. Studies in this domain have used procedures of habituation, head turn, violation of expectation, reaching, and crawling to ask what quantities infants discriminate and represent visually, auditorily as well as intermodally. The concensus view from these studies is that infants possess a numerical ...
Venturini Elisabetta - - 2013
Herpes simplex encephalitis classically involves the periventricular white matter in infants and the mesial temporal lobes, inferior frontal lobes, and insula in older children and adults. However, the increasing use of polymerase chain reaction to detect viral DNA in the cerebrospinal fluid has allowed the expansion of the spectrum of ...
Paes Emma C - - 2013
OBJECTIVES: Mandibular distraction osteogenesis (MDO) has been successfully applied in infants suffering Robin sequence (RS) with severe upper airway obstruction, but no comparative studies for the different types of MDO exist to date. The objective of the current study was to systematically review the published data considering this matter, providing ...
Zhang Ying - - 2013
Very preterm infants are at high risk of death and serious permanent brain damage, as occurs with intraventricular hemorrhage (IVH). Detrended fluctuation analysis (DFA) that quantifies the fractal correlation properties of physiological signals has been proposed as a potential method for clinical risk assessment. This study examined whether DFA of ...
Lipkind Dina D Department of Psychology, Hunter College, City University of New York, New York, NY 10065, USA. - - 2013
Human language, as well as birdsong, relies on the ability to arrange vocal elements in new sequences. However, little is known about the ontogenetic origin of this capacity. Here we track the development of vocal combinatorial capacity in three species of vocal learners, combining an experimental approach in zebra finches ...
Chatterton Dereck E W - - 2013
The human newborn infant is susceptible to gut inflammatory disorders. In particular, growth-restricted infants or infants born prematurely may develop a severe form of intestinal inflammation known as necrotizing enterocolitis (NEC), which has a high mortality. Milk provides a multitude of proteins with anti-inflammatory properties and in this review we ...
Sravish Akhila V - - 2013
A dynamic systems analytical model was used to characterize infant-caregiver regulatory dynamics. Though stable, there was an increase in dyadic flexibility following a perturbation. Dyadic flexibility was positively related to infant negativity during the perturbation. Findings were qualified by infant sex and maternal depressive symptoms.
Oresic Matej M VTT Technical Research Centre of Finland, Espoo, Finland. - - 2013
Previous studies show that children who later progress to type 1 diabetes (T1D) have decreased preautoimmune concentrations of multiple phospholipids as compared with nonprogressors. It is still unclear whether these changes associate with development of β-cell autoimmunity or specifically with clinical T1D. Here, we studied umbilical cord serum lipidome in ...
Marchitti Satori A - - 2013
Women in the United States have breast milk concentrations of polybrominated diphenyl ethers (PBDEs) that are among the highest in the world, leading to concerns over the potential health implications to breastfeeding infants during critical stages of growth and development. Developing cost effective and sustainable methods for assessing chemical exposures ...
Montagna M - - 2013
Palivizumab (Synagis) is a humanized monoclonal antibody (IgG1K) composed of 95 percent human and 5 percent murine sequences. It is directed to an epitope in the A antigenic site of the F protein of respiratory syncytial virus (RSV). Palivizumab is used for prevention of serious lower respiratory tract disease caused ...
Ram Ashok Daya - - 2013
Background/Purpose The purpose of this study was to assess the degree of elevation of serum C-reactive protein (CRP) levels in infants with gastroschisis managed by placement of a preformed silo and subsequent nonoperative closure.Methods CRP measurements were collected prospectively in infants with gastroschisis undergoing preformed silo placement until defect closure. ...
Xiao Wen S WS University of Toronto, - - 2013
The present study investigated whether infants visually scan own- and other-race faces differently as well as how these differences in face scanning develop with age. A multi-method approach was used to analyze the eye-tracking data of 6- and 9-month-old Caucasian infants scanning dynamically displayed own- and other-race faces. We found ...
Cui Hong - - 2013
BACKGROUND: With the improvement of perinatal care and neonatal intensive care technology in recent years, a preterm infant, especially with small gestational age and very low birth weight, survives more and more. At the same time, adverse neurodevelopmental prognosis caused by brain damage in preterm infant also increased significantly. Preterm ...
Gross Bradley A - - 2013
BACKGROUND: Among the technical challenges involved in safely performing neuroendovascular procedures in infants are limitations on the size of femoral arterial access catheters. Restricting groin access to 4 F and 5 F systems constrains the range of procedures that can potentially be performed. METHODS AND RESULTS: We present here a ...
Mash Clay - - 2013
The brain electrical responses of 3-month-old infants were compared between images of familiar and unfamiliar faces. Infants were shown images of their mothers and of appearance-matched female strangers for 500 ms per trial while their electroencephalography was recorded. Electroencephalographic signals were segmented from stimulus onset through 1200 ms, and segments ...
Lane Victoria - - 2013
We report an infant who presented with a discharging single-lumen, tubular, and mucosa-lined umbilical mass and a large central abdominal mass, inferior to the umbilicus. At operation, the mass was discovered to be a prolapsed, open, and inflamed urachal sinus leading to a pyourachus. Primary total excision from dome of ...
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