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Healy C Mary CM aDepartment of Pediatrics, Baylor College of Medicine,bBen Taub General Hospital, cCenter for Vaccine Awareness and Research, Texas Children's Hospital, dUniversity of Texas Health Sciences Center at Houston, Houston, - - 2014
Tetanus, diphtheria and acellular pertussis (Tdap) immunization of infant contacts (cocooning) is recommended by Centers for Disease Control and Prevention to prevent infant pertussis. We determined whether implementing a cocooning program at Ben Taub General Hospital (BTGH), Houston, reduced severe pertussis in young infants. Infants ≤ 6 months of age, ...
Tregnaghi Miguel M Centro de Desarrollo de Proyectos Avanzados, Córdoba, - - 2014
This phase III study assessed the safety and immunogenicity of MenACWY-CRM, a quadrivalent meningococcal conjugate vaccine, administered with routine vaccines starting at 2 months of age. Healthy infants received MenACWY-CRM in a two- or three-dose primary infant series plus a single toddler dose. In addition, a two-dose toddler catch-up series ...
Adam Omer - - 2014
Epidemiological data about congenital rubella syndrome (CRS) are scarce and rubella vaccine is not yet included in the childhood immunization schedule in Sudan. This study aimed to identify and describe CRS cases among Sudanese infants with congenital eye or heart defects. Between February and September 2010, paired oral fluid and ...
Harrison Denise - - 2014
Early childhood immunizations, although vital for preventative health, are painful and too often lead to fear of needles. Effective pain management strategies during infant immunizations include breastfeeding, sweet solutions, and upright front-to-front holding. However, it is unknown how often these strategies are used in clinical practice. We aimed to review ...
Goo Leslie L 1] Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2] Graduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, Washington, - - 2014
Eliciting protective neutralizing antibodies (NAbs) against HIV-1 is daunting because of the extensive genetic and antigenic diversity of HIV-1. Moreover, broad and potent responses are uncommon even during persistent infection, with only a subset of adults developing broadly neutralizing antibodies (bNAbs) that recognize viral variants from different HIV-1 clades. It ...
Hsu Ya-Chi YC Department of Pediatrics, Chiayi Branch, Taichung Veterans General Hospital, Chiayi, - - 2014
The primary aim of the study was to investigate the changes in composition of breast milk from mothers with preterm infants (gestation age < 35 weeks) during the first 4-6 weeks of lactation. Breast milk from 17 mothers who had delivered preterm infants was collected longitudinally for 4-6 weeks. Breast milk from 15 ...
Payne Barbara L BL Department of Paediatrics and Child Health, University of Nairobi, Kenya; Department of Medicine, University of Washington, USA; Department of Global Health, University of Washington, - - 2014
In utero exposure to HIV-1 may affect the immune system of the developing child and may induce HIV-1-specific immune responses, even in the absence of HIV-1 infection. We evaluated lymphoproliferative capacity at birth among 40 HIV-1-uninfected infants born to HIV-1-infected mothers and 10 infants who had acquired HIV-1 in utero. ...
Akin Ilke Mungan IM Division of Neonatology, School of Medicine, Ankara University, Ankara, - - 2014
Objective Lactoferrin (LF) is effective in the prevention of sepsis in very low birth weight (VLBW) neonates. T-regulatory cells (Tregs) are important subsets of T lymphocytes that control pathogen-specific immune responses and are essential for intestinal immune homoeostasis. The aim of the present study is to determine whether oral LF at ...
Wong K K KK Epidemic Intelligence Service assigned to Influenza Division,Centers for Disease Control and Prevention,Atlanta, - - 2014
SUMMARY Death certificate reports and laboratory-confirmed influenza deaths probably underestimate paediatric deaths attributable to influenza. Using US mortality data for persons aged <18 years who died during 28 September 2003 to 2 October 2010, we estimated influenza-attributable deaths using a generalized linear regression model based on seasonal covariates, influenza-certified deaths ...
Munoz Flor M FM Department of Pediatrics, Baylor College of Medicine, Houston, Texas2Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, - - 2014
Maternal immunization with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine could prevent infant pertussis. To evaluate the safety and immunogenicity of Tdap immunization during pregnancy and its effect on infant responses to diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine. Phase 1-2, randomized, double-blind, placebo-controlled, clinical ...
Bardini M M M Tettamanti Research Center; University of Milano Bicocca, Ospedale San Gerardo, Monza, - - 2014
Distinct from most other acute lymphoblastic leukemia (ALL), infant ALL with mixed lineage leukemia (MLL) gene rearrangement, the most common leukemia occurring within the first year of life, might arise without the need for cooperating genetic lesions. Through Ig/TCR rearrangement analysis of MLL-AF4+ infant ALL at diagnosis and xenograft leukemias ...
Dong Ying Y University Children's Hospital, University of Würzburg, Würzburg, Germany; Department of Neonatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing and Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, - - 2014
Neonatal late-onset sepsis (LOS) is a serious problem in neonatal intensive care. Coagulase-negative staphylococci, especially Staphylococcus epidermidis, have emerged as the predominant pathogen of LOS in very low birth weight (VLBW) infants, accounting for up to 77.9% of neonatal LOS in industrialized countries and 46.5% in some developing regions. VLBW ...
Trolice Mark P MP Fertility Center of Assisted Reproduction and Endocrinology, Winter Park, Florida. Electronic address: - - 2014
To report a live birth with IVF from a 46-year-old woman using autologous oocytes. Case report. Reproductive endocrinology and infertility private practice and ambulatory IVF center. One 46-year-old nulligravid woman. IVF with fresh ET. Live birth after IVF. A 46-year-old with antimullerian hormone (AMH) level less than 0.16 conceived through ...
Tanticharoenwiwat Pattara - - 2014
Infants who were readmitted with high level of bilirubin (more than 20 mg/dl) should be treated as an acute medical emergency to prevent acute and chronic bilirubin encephalopathy. To determine causes of severe neonatal hyperbilirubinemia, risk factors for exchange transfusion and outcomes of neonate after implementation of the jaundice fast-track ...
Drell Tiina T Institute of Microbiology; University of Tartu; Tartu, Estonia; Centre for Biology of Integrated Systems; Tallinn University of Technology; Tallinn, Estonia; Competence Centre on Reproductive Medicine and Biology; Tartu, - - 2014
An increasing number of studies that are using high-throughput molecular methods are rapidly extending our knowledge of gut microbial colonization in preterm infants whose immaturity and requirement for extensive treatment may result in altered colonization process. We aimed to describe the profile of gut microbiota in 50 extremely low birth ...
Kidzeru Elvis B EB aDivision of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town bDesmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, Parow cDivision of Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town dNational Health Laboratory Sciences, South Africa eDivision of Epidemiology & Biostatistics, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa fSeattle Biomedical Research Institute, Seattle, Washington, - - 2014
In sub-Saharan Africa, HIV-exposed uninfected (HEU) infants have higher morbidity and mortality than HIV-unexposed infants. To evaluate whether immune dysfunction contributes to this vulnerability of HEU infants, we conducted a longitudinal, observational cohort study to assess T-cell immune responses to infant vaccines (Mycobacterium bovis BCG and acellular pertussis) and staphylococcal ...
Jones R P RP Healthcare Analysis & Forecasting, Honister Walk, Camberley GU15 1RQ, UK. Electronic address: - - 2014
In early 2012 deaths (all-cause mortality) in England and Wales showed an unexpected and unexplained increase which continued for 18months before abating. The highest percentage increase in deaths was noted to be for neurological degenerations (mainly dementia, Alzheimer's, Parkinson's). This study seeks to understand why increased deaths should focus on ...
Le Doare Kirsty K Imperial College London, Department of Paediatrics, St. Mary's Hospital, Praed Street, London, W2 1NY, UK; Wellcome Trust Centre for Global Health Research, Norfolk Place, London, UK; MRC Unit, Vaccinology Theme, Atlantic Road, Fajara, Gambia. Electronic address: - - 2014
Invasive Group-B streptococcal (GBS) disease is a leading cause of infant mortality and morbidity worldwide. GBS colonises the maternal rectum and vagina and transmission of bacteria from a colonized mother to her infant at birth is an important risk factor for GBS disease. GBS disease has also been associated with ...
Reikie Brian A BA 1Division of Infectious & Immunological Diseases, and Centre for Understanding and Preventing Infections in Children, Department of Pediatrics, University of British Columbia, Vancouver, V5Z 4H4, Canada 2Immunology Unit, Division of Medical Microbiology, Department of Pathology, NHLS and Stellenbosch University, PO 19063, Tygerberg 7505 South Africa 3Division of Medical Virology, Department of Pathology, NHLS and Stellenbosch University, PO 19063, Tygerberg 7505 South Africa 4Department of Paediatrics and Child Health, Tygerberg Children's Hospital and Stellenbosch University, PO 19063, Tygerberg 7505 South Africa 5Leaders in Medicine Program, University of Calgary, Calgary, T2N 4N1, - - 2014
Early in life HIV-exposed uninfected (HEU) infants are at an increased risk of morbidity and mortality from infectious disease compared to HIV-unexposed (UE) infants. To improve our understanding of the mechanisms underlying their increased risk, we contrasted innate immune development between HEU and UE infants in a developing world setting, ...
Zhang Lei L Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China, - - 2014
Hepatitis B virus (HBV) infection is of high prevalence in China. Mother-to-infant transmission is the major route for HBV transmission and subsequent chronicity. This study aimed to investigate current HBsAg-positive rate among pregnant women and immunoprophylaxis outcome in China. Multicenter prospective study was conducted in 10 centers. From 2008 to ...
McDonald Suzanna L - - 2014
Vitamin A supplementation significantly reduces all-cause mortality when given between 6-59 months of age, but has a null or detrimental effect when given between 1-5 months. Studies of neonatal vitamin A supplementation conducted across Africa and South Asia have produced conflicting findings. These age-pattern variations might result from immunological interactions ...
Winkler Beate B Department of Paediatric Haematology/Oncology and Stem Cell Transplantation, University Children's Hospital, Joseph-Schneider-Str. 2, 97080, Würzburg, - - 2014
Breast-feeding (BF) versus formula-feeding (FF) may be a factor for the development and differentiation of T-cell subsets and cytokine production in infancy and childhood. We therefore investigated T-cell subpopulations and their cytokine production by flow cytometry as well as cytokine levels in serum samples in breast-fed versus formula-fed infants and ...
Derscheid Rachel J RJ Department of Veterinary Pathology, Iowa State University , College of Veterinary Medicine, Ames, - - 2014
Respiratory syncytial virus (RSV) is the leading cause of hospitalization due to respiratory illness among infants and young children of industrialized countries. There is a lack of understanding of the severe disease mechanisms as well as limited treatment options, none of which are fully satisfactory. This is partly due to ...
Groer Maureen M 1University of South Florida College of Nursing, Tampa, FL, - - 2014
Background:There has been a recent increase in availability of banked donor milk for feeding of preterm infants. This milk is pooled from donations to milk banks from carefully screened lactating women. The milk is then pasteurized by the Holder method to remove all microbes. The processed milk is frozen, banked, ...
Ward Tonya L TL Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, - - 2014
Soluble CD14 (sCD14) is a pattern recognition receptor and Toll-like co-receptor observed in human milk (5-26μg/mL) and other bodily fluids such as blood (3μg/mL). The most well defined role of sCD14 is to recognize lipopolysaccharide of Gram-negative bacteria and signal an immune response through Toll-like receptor 4 (TLR4). Previous research ...
Albokrinov Andrew A AA From the Regional Children's Clinic Hospital, Lviv, - - 2014
Thoracolumbar paravertebral block (PVB) is one method of providing regional anaesthesia for abdominal wall surgery in children. It is common practice when performing a PVB for abdominal wall anaesthesia to inject a certain volume of local anaesthetic solution in the paravertebral space at several levels. This increases the duration of ...
Ahlfeld Shawn K SK Developmental Biology and Neonatal Medicine Program, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, - - 2014
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of extreme prematurity and is defined clinically by dependence on supplemental oxygen due to impaired gas exchange. Optimal gas exchange is dependent on the development of a sufficient surface area for diffusion. In the mammalian lung, rapid acquisition of distal lung surface ...
Romano-Keeler Joann J Department of Pediatrics; Vanderbilt University; Nashville, TN - - 2014
Fecal sampling is widely utilized to define small intestinal tissue-level microbial communities in healthy and diseased newborns. However, this approach may lead to inaccurate assessments of disease or therapeutics in newborns because of the assumption that the taxa in the fecal microbiota are representative of the taxa present throughout the ...
Davidson Autumn P AP Veterinary Medical Teaching Hospital Small Animal Clinic, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA 95616, USA; Pet Care Veterinary Hospital, East Campus, 2425 Mendocino Avenue, Santa Rosa, CA 95403, USA. Electronic address: - - 2014
Prudent veterinary intervention in the prenatal, parturient, and postpartum periods can increase neonatal survival by controlling or eliminating factors contributing to puppy morbidity and mortality. Postresuscitation or within the first 24 hours of a natural delivery, a complete physical examination should be performed by a veterinarian, technician, or knowledgeable breeder. Adequate ...
Chahroudi Ann A Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America; Yerkes National Primate Research Center, Atlanta, Georgia, United States of - - 2014
Mother-to-infant transmission (MTIT) of HIV is a serious global health concern, with over 300,000 children newly infected in 2011. SIV infection of rhesus macaques (RMs) results in similar rates of MTIT to that of HIV in humans. In contrast, SIV infection of sooty mangabeys (SMs) rarely results in MTIT. The ...
Longo Stefania S Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: - - 2014
Intra-uterine growth retardation (IUGR) is usually defined as impaired growth and development of the fetus and/or its organs during gestation. Infants are defined small for gestational age (SGA), following IUGR, when the birth weight is below the 10th percentile. Pre-natal congenital infections caused by T. gondii, rubella, cytomegalovirus (CMV), herpes ...
Chaves Sandra S SS 1Centers for Disease Control and Prevention, Atlanta, GA 2Emory University School of Medicine, Atlanta, GA 3Atlanta Veterans Administration Medical Center, Atlanta, GA 4Colorado Department of Public Health and Environment, Denver, CO 5Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN 6Michigan Department of Community Health, Lansing, MI 7Connecticut Emerging Infections Program, Yale University, New Haven, CT 8Oregon Public Health Division, Portland, OR 9Utah Department of Health, Salt Lake City, UT 10New Mexico Department of Health, Santa Fe, NM 11Rhode Island Department of Health, Providence, RI 12Minnesota Department of Health, St. Paul, MN 13Emerging Infections Program, New York State Department of Health, Albany, NY 14California Emerging Infections Program, Oakland, CA 15Department of Medicine, University of Rochester School, of Medicine and Dentistry, Rochester, NY 16Monroe County, Department of Public Health, Rochester, NY 17Maryland Department of Health and Mental Hygiene, Baltimore, MD 18Ohio Department of Health, Columbus, - - 2014
Little information is available describing the epidemiology and clinical characteristics of those <12 months hospitalized with influenza, particularly at a population level. We used population-based, laboratory-confirmed influenza hospitalization surveillance data from 2003-2012 seasons to describe the impact of influenza by age category (<3, 3 to <6 and 6 to <12 ...
Groome Michelle J MJ Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, PO Box 90753, Bertsham, 2013, Gauteng, South - - 2014
To investigate the effect of abstention from breastfeeding, for an hour before and after each vaccination, on the immune responses of infants to two doses of rotavirus vaccine. In Soweto, South Africa, mother-infant pairs who were uninfected with human immunodeficiency virus (HIV) were enrolled as they presented for the "6-week" ...
Gephart Sheila M SM College of Nursing, University of Arizona, Tucson (Dr Gephart); and Neonatal Intensive Care Unit, Phoenix Children's Hospital, Arizona (Ms - - 2014
It is well known that the immune response is blunted and underdeveloped in the premature infant, but human milk supports the infant's growth, function, and effectiveness. Thus, own mother's colostrum (OMC) administered oropharyngeally has potential to deliver oral immune therapy (C-OIT) even before enteral feedings have begun. Colostrum interacts with ...
Pifko Elysha E Resident Physician (Pifko), Pediatric Emergency Medicine Fellow (Price), Pediatric Emergency Medicine Attending Physician (Sterner), Medical University of South Carolina, Charleston, - - 2014
Infant botulism is caused by the ingestion of Clostridium botulinum spores and leads to a life-threatening descending motor weakness and flaccid paralysis in infant children. This disease presents with symptoms such as constipation, weakness, and hypotonia and can lead to respiratory failure. Botulism immune globulin (BIG) was created to treat ...
Penders John J Department of Medical Microbiology; School for Nutrition, Toxicology, and Metabolism; Maastricht University Medical Centre; Maastricht, the Netherlands; Department of Epidemiology; School for Public Health and Primary Care; Maastricht University; Maastricht, the - - 2014
There is convincing evidence from both human and animal studies suggesting that the infant intestinal microbiota plays an important role in regulating immune responses associated with the development of allergic diseases. To date there are, however, still no definite bacterial taxa or particular subsets of the microbiota that have been ...
Tobin Nicole H NH Department of Pediatrics, Children's Hospital Los Angeles, 4650 Sunset Blvd., MS#51, Los Angeles, CA, 90027, - - 2014
The recent report of an infant that appears to have achieved a "functional cure" of HIV-1 following receipt of antiretroviral therapy (ART) within 30 hours of birth raises many questions: was the child infected? Was this result due to unique features of this particular infant's immune system, the immune system of ...
Liao Sui-Ling SL 1Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Chang Gung University College of Medicine , Taoyuan , - - 2014
G6PD-deficient adults are reported to be susceptible to severe infection, and decreased cytokine responses have been postulated as the underlying mechanism. However, investigating the association of G6PD deficiency and cytokine responses during infancy is lacking. The current study aims to determine whether cytokine responses of tumor necrosis factor ()-α, interleukins ...
Kallapur Suhas G SG Division of Neonatology/Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of - - 2014
Chorioamnionitis is a frequent cause of preterm birth and is associated with an increased risk for injury responses in the lung, gastrointestinal tract, brain, and other fetal organs. Chorioamnionitis is a polymicrobial nontraditional infectious disease because the organisms causing chorioamnionitis are generally of low virulence and colonize the amniotic fluid ...
Latuga M Susan MS Department of Pediatrics, Division of Neonatology, Albert Einstein College of Medicine, Bronx, New - - 2014
Breast milk contains a rich microbiota composed of viable skin and non-skin bacteria. The extent of the breast milk microbiota diversity has been revealed through new culture-independent studies using microbial DNA signatures. However, the extent to which the breast milk microbiota are transferred from mother to infant and the function ...
Zagato Elena E Department of Experimental Oncology, European Institute of Oncology, Milan, - - 2014
The rapid expansion of commercially available fermented food products raises important safety issues particularly when infant food is concerned. In many cases, the activity of the microorganisms used for fermentation as well as what will be the immunological outcome of fermented food intake is not known. In this manuscript we ...
P Suryawanshi S Associate Professor, Division of Neonatology, Department of Pediatrics, Bharati Vidyapeeth University Medical College,Neonatal Intensive Care Unit (NICU) Incharge & Consultant Neonatologist, Bharati Hospital , Pune-411043, - - 2014
We report a case of a preterm neonate with isolated spontaneous pneumopericardium occurring in the absence of a history of neonatal resuscitation, mechanical ventilation, major lung disease or another air leak. The pneumopericardium was asymptomatic and resolved without the need for aspiration, although the "nitrogen washout" technique was used.
van den Berg Jolice P JP Department of Paediatrics, Division of Neonatology, VU University Medical Center, Amsterdam, The - - 2014
Maternal antibodies, transported over the placenta during pregnancy, contribute to the protection of infants from infectious diseases during the first months of life. In term infants, this protection does not last until the first recommended measles-mumps-rubella vaccination at 14 months in the Netherlands, while these viruses still circulate. The aim ...
Ziegler Ekhard E EE Department of Pediatrics, University of Iowa, Iowa City, Iowa, - - 2014
Human milk contains numerous immune-protective components that protect the premature infant from sepsis and necrotizing enterocolitis. Because of these protective effects, human milk is the feeding of choice for the premature infant. However, human milk does not provide adequate amounts of most nutrients for premature infants and must therefore be ...
Wang Shugui S Department of Microbiology, National University of Singapore, Singapore, Singapore; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore, - - 2014
Colonizing commensal bacteria after birth are required for the proper development of the gastrointestinal tract. It is believed that bacterial colonization pattern in neonatal gut affects gut barrier function and immune system maturation. Studies on the development of faecal microbiota in infants showed that the neonatal gut was first colonized ...
Libraty Daniel H DH Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of - - 2014
Dengue is the most prevalent arthropod-borne viral illness in humans. A MHC class I polypeptide-related sequence B (MICB) single nucleotide polymorphism (SNP) was previously associated with symptomatic dengue compared to non-dengue causes of acute febrile illnesses in infants. We measured circulating levels of soluble (s)MICB in the sera of infants ...
Ackermann Mark R - - 2014
Preterm birth is a risk factor for respiratory syncytial virus (RSV) bronchiolitis and hospitalization. The pathogenesis underlying this is not fully understood, and in vivo studies are needed to better clarify essential cellular features and molecular mechanisms. Such studies include analysis of lung tissue from affected human infants and various ...
Forsberg Anna A Department of Clinical and Experimental Medicine, Unit of Autoimmunity and Immune Regulation, Division of Clinical Immunology, Linköping University, SE-581 85 Linköping, - - 2014
Mice models indicate that intact Toll like receptor (TLR) signaling may be essential for the allergy protective effects of diverse bacterial exposure observed in clinical trials and epidemiological studies. Probiotic supplementation with Lactobacillus reuteri from pregnancy week 36 and to the infant through the first year of life decreased the ...
Urbaniak Camilla C Lawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada ; Department of Microbiology & Immunology, Western University, London, ON N6A 5C1, - - 2014
Human milk is an important source of bacteria for the developing infant and has been shown to influence the bacterial composition of the neonatal gut, which in turn can affect disease risk later in life. Human milk is also an important source of nutrients, influencing bacterial composition but also directly ...
Lanari Marcello M 0000-0002-2586-314X Pediatrics and Neonatology Unit, Imola Hospital, Via Montericco 4, 40026 Imola, - - 2014
Primary immunodeficiencies are rare inherited disorders that may lead to frequent and often severe acute respiratory infections. Respiratory syncytial virus (RSV) is one of the most frequent pathogens during early infancy and the infection is more severe in immunocompromised infants than in healthy infants, as a result of impaired T- ...
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