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Van Zutphen Alissa R - - 2012
Although hyperthermia is a recognized animal teratogen and maternal fever has been associated with birth defects in humans, data on the relationship between high environmental temperatures and birth defects are limited. To determine whether pregnancies are potentially vulnerable to the weather extremes anticipated with climate change, we evaluated the relationship ...
Nuntnarumit Pracha - - 2012
Objective:  To determine the feasibility of 50-60% oxygen resuscitation by a simple method using a self-inflation bag without oxygen reservoir for positive pressure ventilation (PPV) or using a constant distance and flow rate for blow-by-oxygen. Methods:  Newly born infants ≤ 35 wk gestational age were eligible. Infants requiring PPV were ...
Heald Alicia - - 2012
Abstract Background/Objective: Hyperglycaemia is common in very premature neonates and is associated with increased risk of intra-ventricular haemorrhage, necrotising enterocolitis, sepsis and death. Administration of insulin may risk hypoglycaemia and associated complications. To determine effects of insulin infusions in very premature infants on morbidity, mortality and long-term neurodevelopmental outcome. Methods: ...
Sehgal Arvind - - 2012
Perinatal asphyxia can lead to multi-organ insult which includes cardiovascular dysfunction. The objective was to study the relationship between cardiac function, perfusion and troponin. Unit database was accessed to identify infants with perinatal asphyxia over the last 2 years. Information from medical records and archived echocardiographic images was retrieved. Comparisons for ...
Murthy Vadivelam - - 2012
BACKGROUND: Successful resuscitation of prematurely born infants is dependent on achieving adequate alveolar ventilation and vasodilation of the pulmonary vascular bed. Elevation of end-tidal carbon dioxide (ETCO(2)) levels may indicate pulmonary vasodilation. AIMS: This research aims to study the temporal changes in ETCO(2) levels and the infant's respiratory efforts during ...
Pickerd N - - 2012
Tidal breathing measurements which provide a non-invasive measure of lung function in preterm and term infants are particularly useful to guide respiratory support. We used a new technique of electromagnetic inductance plethysmography (EIP) to measure tidal breathing in infants between 32 and 42 weeks postconceptional age (PCA). Tidal breathing was ...
Caplow Julie - - 2012
Objectives: The primary aim of the study was to determine the changes, if any, in cardiac output (CO) and stroke volume (SV) in normal infants with RSV bronchiolitis. The secondary aim was to determine whether changes in CO (ΔCO) and SV (ΔSV) are associated with changes in respiratory rate (ΔRR). ...
Weisz Dany E - - 2012
Objectives: Non-invasive cardiac output monitoring is a potentially useful clinical tool in the neonatal setting. Our aim was to evaluate a new method of non-invasive continuous cardiac output (CO) measurement (NICOM™) based on the principle of bioreactance in neonates. Methods: In this prospective observational study, 10 neonates underwent 97 paired ...
Sommers Ross - - 2012
Delayed cord clamping (DCC) has been advocated during preterm delivery to improve hemodynamic stability during the early neonatal period. The hemodynamic effects of DCC in premature infants after birth have not been previously examined. Our objective was to compare the hemodynamic differences between premature infants randomized to either DCC or ...
Lam Francis - - 2012
The primary objective of this study was to evaluate the hemodynamic effects of dexmedetomidine (DEX) infusion on critically ill neonates and infants with congenital heart disease (CHD). The secondary objective of the study was to evaluate the safety and efficacy profile of the drug in this patient population. A retrospective ...
Davis Peter G - - 2012
PURPOSE OF REVIEW: There has been a substantial increase in the number of studies of neonatal resuscitation and it is timely to review the accumulating evidence. RECENT FINDINGS: There have been major changes in the way that newly born infants are managed in the delivery room. Colour is no longer ...
Koh Jeremy - - 2012
BACKGROUND: Using pure oxygen (PO) in neonatal resuscitation increases oxidative stress and mortality in full-term hypoxic infants. International neonatal resuscitation guidelines recommend air or blended oxygen for resuscitation regardless of gestational age but this requires education and equipment that may not be globally available. OBJECTIVE: To determine current neonatal resuscitation ...
Schilleman Kim - - 2012
OBJECTIVE: To evaluate compliance with neonatal resuscitation guidelines during resuscitation of preterm infants by video recording of delivery room management and monitoring physiologic parameters. METHODS: The delivery room management of preterm infants at birth was recorded by an independent researcher. Physiological parameters (airway pressures, gas flow, tidal volume, heart rate ...
Sarici A M - - 2012
To evaluate the relationship between serum total homocysteine levels and retinopathy of prematurity (ROP). This prospective case-control study involved premature infants diagnosed with ROP 4 weeks after birth (cases); controls were premature infants not developing ROP during follow-up. Fasting serum total homocysteine concentrations were determined in all participants 4 weeks ...
Kaneyasu Maya - - 2012
Infants in the Neonatal Intensive Care Unit may experience a myriad of painful procedures and stressful experiences. Pain management for infants requiring mechanical ventilation is complex and challenging especially in the preterm population. Many infants may not receive analgesia, primarily due to the unknown long-term neurodevelopmental effects of morphine exposure ...
Silva Camila de A Cde - - 2012
The occurrence of a respiratory syncytial virus (RSV) outbreak in a Neonatal Intensive Care Unit (NICU) is related to unfavorable outcomes, as this infection can lead to respiratory distress and death in premature in infants. Report the successful control of an outbreak that occurred in April 2010 in a NICU. ...
Alberts Jeffrey R - - 2012
Traditionally, the development of oral feeding is viewed as a continuous, unitary process in which reflex-dominated sucking behavior gives rise to a more varied and volitional feeding behavior. In contrast, we consider the thesis that the infant develops two separable ingestive systems, one for suckling and one for feeding. First, ...
Rook Denise - - 2012
Resuscitation at birth with 100% oxygen is known to increase the oxidative burden with concomitant deleterious effects. Although fractions of inspired oxygen (FiO₂) < 100% are widely used in preterm infants, starting resuscitation at a (too) low FiO₂ may result in hypoxia. The objective of this study is to compare the ...
Poletta Fernando A - - 2012
Different approaches have been used in case-control studies to estimate maternal exposure to medications and the risk of birth defects. However, the performance of these approaches and how they affect the odds ratio (OR) estimates have not been evaluated using birth-defect surveillance programmes. The aim of this study was to ...
Czernik Christoph - - 2012
Elevated pulmonary vascular resistance occurs during the first days after birth in all newborn infants and persists in infants at risk for bronchopulmonary dysplasia (BPD). It is difficult to measure in a non-invasive fashion. We assessed the usefulness of the right ventricular index of myocardial performance (RIMP) to estimate pulmonary ...
Le Compte Aaron J - - 2012
Hyperglycemia often occurs in premature, very low birthweight infants (VLBW) due to immaturity of endogenous regulatory systems and the stress of their condition. Hyperglycemia in neonates has been linked to increased morbidities and mortality and occurs at increasing rates with decreasing birthweight. In this cohort, the emerging use of insulin ...
Tomori Zoltan - - 2012
Agonal gasping provoked by asphyxia can save ~15% of mammals even from untreated ventricular fibrillation (VF), but it fails to revive infants with sudden infant death syndrome (SIDS). Our systematic study of airway reflexes in cats and other animals indicated that in addition to cough, there are two distinct airway ...
Cardenas Paul Andres PA National Heart & Lung Institute, Imperial College London, United - - 2012
Observations that the airway microbiome is disturbed in asthma may be confounded by the widespread use of antibiotics and inhaled steroids. We have therefore examined the oropharyngeal microbiome in early onset wheezing infants from a rural area of tropical Ecuador where antibiotic usage is minimal and glucocorticoid usage is absent. ...
Abdellatif Mohamed M Child Health Department, Neonatal Unit, Sultan Qaboos University Hospital, Muscat, Oman. - - 2012
With more and more extreme premature and very low-birth weight babies being resuscitated, umbilical central venous catheterisation is now being used more frequently in neonatal intensive care. The authors present a case of cardiac tamponade following umbilical venous catheterisation in a neonate, an uncommon, yet potentially fatal complication. The patient ...
Iyer Srikant B - - 2011
Although interventions to improve outcomes for children with congenital heart disease may be designed and tested, the rarity of any one specific defect presents a barrier to using traditional statistical methods to measure the effects of these interventions. The purpose of this report is to describe the innovative statistical approach ...
Norman Elisabeth - - 2011
OBJECTIVES: To compare rapid sequence intubation (RSI) premedication with morphine for intubation of preterm infants. STUDY DESIGN: Preterm infants needing semi-urgent intubation were enrolled to either RSI (glycopyrrolate, thiopental, suxamethonium, and remifentanil, n = 17) or atropine and morphine (n = 17) in a randomized trial. The main outcome was ...
Srinivasjois Ravisha - - 2011
Objective: To study the efficacy of early meconium evacuation using per rectal laxatives on the level of serum bilirubin and the need for phototherapy in healthy term infants. Materials and Methods: Systematic review of randomized controlled trials comparing per rectal laxatives versus no intervention was conducted using English language articles ...
Whalen D H - - 2011
The article by MacNeilage and Davis in this issue, entitled "In Defense of the 'Frames, then Content' (FC) Perspective on Speech Acquisition: A Response to Two Critiques" appears to assume that the only alternative to segment-level control is oscillation specifically of the jaw; however, other articulators could be oscillated by ...
Koshinaga Tsugumichi - - 2011
Background:  Meconium obstruction without cystic fibrosis in low-birthweight neonates is a distinct clinical entity. We aimed to determine what therapeutic strategies work best in very-low-birthweight neonates with meconium obstruction of the small bowel under varied clinical conditions caused by the associated diseases of prematurity. Methods:  Medical records of very-low-birthweight neonates ...
Claas M J - - 2011
Extremely low birth weight (ELBW) infants are at risk of impaired postnatal growth. Impaired postnatal growth has been reported to be associated with delayed cognitive and motor development. To describe postnatal growth patterns of appropriate and small for gestational age (AGA and SGA) ELBW children in relation to their cognitive ...
Ram Kumar T V - - 2011
This was a randomized blinded placebo controlled trial undertaken to study the role of zinc supplementation on growth, primarily the linear growth velocity in very low birth weight (VLBW) infants at 3 months corrected age (CA). Out of 134 neonates with birth weight <1500 g, 101 babies were eligible. Due to ...
Urlesberger Berndt - - 2011
OBJECTIVE: To evaluate differences in regional oxygen saturation of the brains of term infants of vaginal or cesarean deliveries. STUDY DESIGN: Vaginal delivery (n = 63) and elective cesarean delivery infants were prospectively evaluated for the first 10 minutes after delivery. Peripheral arterial oxygen saturation (SpO(2)) and heart rate were ...
Schillaci Michael A - - 2011
The present study examines patterns of infant and juvenile growth in a diachronic sample of ancestral Pueblo Indians (AD 1300-1680) from the American Southwest. An assessment of growth patterns is accompanied by an evaluation of pathological conditions often considered to be indicators of nutritional deficiencies and/or gastrointestinal infections. Growth patterns ...
Lampl Michelle - - 2011
BACKGROUND: Rapid growth rates of head circumference and body size during infancy have been reported to predict developmental pathologies that emerge during childhood. AIMS: This study investigated whether growth in head circumference was concordant with growth in body length. SUBJECTS: Forty infants (16 males) were followed between the ages of ...
Pridham Karen - - 2011
The small sample sizes of studies involving preterm infants limit the use of statistics for examination of multivariate conditions contributing to clinically important growth dimensions of weight: rate of weight gain, body composition (fat-free and fat mass), and weight relative to reference infants (z score). The authors used graphical analyses, ...
Morgan J A - - 2011
Preterm infants, especially very preterm infants, are usually growth-restricted at the time of hospital discharge. Proposed interventions to promote catch-up growth following hospital discharge include multinutrient fortification of expressed breast milk for breastfed infants and nutrient-enriched formula milk for formula-fed infants. The current evidence to support these strategies is limited. ...
Butler Merlin G - - 2011
To generate and report standardized growth curves for weight, length, head circumference, weight/length, and BMI for non-growth hormone-treated white infants (boys and girls) with Prader-Willi syndrome (PWS) between 0 and 36 months of age. The goal was to monitor growth and compare data with other infants with PWS. Anthropometric measures ...
Jaeger E - - 2011
Objective:The aim of this study was to assess cerebellar growth of very low birth weight infants from birth to discharge and compare it with term infants.Study Design:Very low birth weight infants were matched by gender, adequacy of weight to gestational age at birth and postmenstrual ages at hospital discharge to ...
Sykes Sarah - - 2011
Aims:  There is uncertainty about the best method of withdrawing supplemental oxygen in babies with chronic neonatal lung disease (CNLD). Some authors advocate withdrawal of oxygen in the day, but continuing supplementation during sleep, based on early work suggesting that oxygen saturations are lower during sleep, which did not accord ...
Poddutoor Preetham Kumar - - 2011
The aim was to study the efficacy of rescue High Frequency Oscillatory Ventilation (HFOV) in improving the oxygenation and ventilation in neonates with acute respiratory failure after failing Conventional Mechanical Ventilation (CMV). Primary outcome was short term oxygenation, lung recruitment, and ventilation and secondary outcome studied was survival. 675 babies ...
Sullivan Stephanie A - - 2011
To examine how urban parents' perceptions of healthy infant size and growth relate to objective weight-for-length percentiles of their children, parents of 222 (69% minority) 6- to 27-month-old infants were surveyed. In all, 41% of parents said growth charts had never been explained to them, and 31% were not confident ...
Vento Maximo - - 2011
Resuscitation is the most common procedure performed in neonatology. However, new contributions based on scientific evidence challenge the traditional procedures. Of these new contributions, the use of room-air instead of 100% oxygen and titration of the oxygen inspiratory fraction according to oximetry and heart rate represent a new approach in ...
Johnson Krystal - - 2011
Preterm infants in neonatal intensive care units frequently require oxygen therapy. Clinicians are responsible for titrating oxygen to maximize the benefits and minimize the risks of this therapy. Studies have identified various toxic effects of oxygen on the developing tissues of the preterm infant; however, optimal target SpO2 ranges have ...
Bassan Haim - - 2011
Late onset intrauterine growth restriction is a common form of growth restriction, mainly caused by placenta-vascular insufficiency. Whether the intrauterine or extrauterine environment offers a better long-term outcome for the growth-restricted fetus remains unclear. We compared the risk factors and long-term outcomes of late onset growth-restricted neonates delivered between 31-36 ...
Cervantes Amanda C - - 2011
This study examines the experience of mothers whose very low-birth-weight infants require the delivery of supplemental oxygen during their hospitalization in the neonatal intensive care unit (NICU). Eleven mothers of very low-birth-weight infants who have received various supplemental oxygen delivery methods in the NICU for a minimum of 7 days ...
Moore Gregory P - - 2011
Neonatology, in large part due to its population of babies born at the edge of viability, is rife with bioethical issues. This unique population is at high risk of mortality and considerable neurodevelopmental morbidity. One contentious, ongoing debate concerns whether these extremely low birth weight infants born at the border ...
Harigopal S - - 2011
Aim To establish a reference range for oxygen saturation (SpO(2)) in well preterm infants to guide home oxygen therapy using a pulse oximeter and Pulse Oximetry Data Analysis Software (PODS). Methods SpO(2) and heart-rate profiles of healthy preterm infants receiving mechanical ventilation for less than 6 h and supplemental oxygen ...
Hansen-Pupp Ingrid - - 2011
Pronounced growth restriction occurs after very preterm birth. The interaction between IGF-I, nutritional intake and growth was evaluated prospectively in 64 infants with a mean (SD) GA of 25.7 (1.9) weeks. Blood sampling of IGF-I and measurements of weight, length and head circumference were performed weekly until discharge. Daily calculation ...
Ishimaru Daichi - - 2011
Bacille Calmette-Guérin osteomyelitis in infants is a known complication of Bacille Calmette-Guérin vaccination. Treatment consists of antituberculosis chemotherapy after biopsy/curettage; however, in cases of Bacille Calmette-Guérin osteomyelitis extending to the growth plate and epiphysis, the extent and time of surgical treatment such as curettage/biopsy is unknown because of bone growth ...
Cosmi Erich - - 2011
Intrauterine growth restriction is a condition fetus does not reach its growth potential and associated with perinatal mobility and mortality. Intrauterine growth restriction is caused by placental insufficiency, which determines cardiovascular abnormalities in the fetus. This condition, moreover, should prompt intensive antenatal surveillance of the fetus as well as follow-up ...
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