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Feltovich Helen H *Maternal-Fetal Medicine, Intermountain Healthcare, Provo, Utah †Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin ‡Division of Maternal-Fetal Medicine, Tufts Medical Center, Boston, - - 2014
A multitude of pathophysiologic pathways culminate in the final common denominator of cervical softening, shortening, and dilation that lead to preterm birth. At present, a variety of emerging technology aims to objectively quantify critical cervical parameters such as microstructural organization and softening of the cervix. If the nature and timing ...
Le Doare K K Wellcome Trust/Imperial Centre for Global Health Research, Imperial College, London, - - 2014
Herpes simplex encephalitis (HSE) is the most common single cause of viral encephalitis in infants and children. Treated or untreated, it can be associated with considerable morbidity and mortality, and its presentation is usually insidious and non-specific. Prompt and careful investigation is important in order to establish the diagnosis so ...
Bakker N E NE Dutch Growth Research Foundation, Rotterdam, The Netherlands; Erasmus MC/ Sophia Children's Hospital, Department of Pediatrics, Subdivision of Endocrinology, Rotterdam, The Netherlands. Electronic address: - - 2014
Boys with Prader-Willi syndrome (PWS) often have undescended testes. Prospective studies on treatment of cryptorchidism in boys with PWS are lacking. Our aim was to evaluate the effects of human Chorionic Gonadotropin (hCG) treatment on testis position. In those who underwent orchidopexy, biopsy was taken and testis histology studied. Sixteen ...
Guerra Luis L Division of Urology, Children's Hospital of Eastern Ontario (CHEO), 401 Smyth Rd, Ottawa, ON, Canada K1H - - 2014
The purpose of this article is to review normal developmental bladder physiology in infants and bladder dysfunction in conditions such as neurogenic bladder, posterior urethral valves and high grade vesicoureteric reflux. We contrast the classical concept that bladder function in nontoilet-trained children is thought to be 'reflexive' or 'uninhibited', with ...
Iyer Narayan Prabhu NP Department of Pediatrics, Division of Neonatology, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, Ohio, 44109, - - 2014
Surfactant replacement therapy has been used for few decades for the treatment of respiratory distress syndrome (RDS) and has significantly improved morbidity and mortality in premature infants. Non-invasive respiratory support has recently emerged as a strategy in the early management of RDS. In this review, we discuss the different strategies ...
Kocherlakota Prabhakar P Division of Neonatology, Department of Pediatrics, Maria Fareri Children's Hospital at New York Medical College, Valhalla, New York - - 2014
Neonatal abstinence syndrome (NAS) is a result of the sudden discontinuation of fetal exposure to substances that were used or abused by the mother during pregnancy. Withdrawal from licit or illicit substances is becoming more common among neonates in both developed and developing countries. NAS continues to be an important ...
Mukherjee Arindam A Department of Neonatology, St Georges University Hospital, London, - - 2014
In August 2012, new national guidance (National Institute of Health and Care Excellence (NICE) CG149) for management of early onset sepsis (EOS) was introduced in the UK. The guidance outlined a consistent approach for septic screens in newborn infants based on risk factors, and suggested biochemical and clinical parameters to ...
Attar M A MA Department of Pediatrics and Communicable Diseases, University of Michigan Health System, Ann Arbor, MI, - - 2014
We evaluated the use of prenatal steroids and the effect of that practice on hospital mortality of late preterm infants with complex congenital heart defects (CHD). Retrospective review of records of late preterm infants with complex CHD infants that were cared for in a single tertiary perinatal center between 2002 ...
Triantafyllou Panagiota P First Department of Pediatrics, Aristotle University of Thessaloniki, Egnatia St. 106, 54622, Thessaloniki, - - 2014
We performed a systematic neurophysiological evaluation of newborns-infants newly diagnosed with congenital hypothyroidism and started on replacement therapy, in order to document the maturation of visual, auditory and somesthetic pathways and to evaluate the influence of treatment. Twenty-one patients (9 boys, 12 girls) were studied. They underwent neurophysiological evaluation consisting ...
De Rose Domenico Umberto DU Division of Neonatology, Department of Pediatrics, Catholic University of Sacred Heart, Rome, Italy. Electronic address: - - 2014
Little is known regarding the prognostic role of Multichannel Intraluminal Impedance and pH monitoring (MII/pH) parameters in preterm infants with Gastro-Esophageal Reflux Disease (GERD). Our study aimed to evaluate the relationship between MII/pH variables and the duration of pharmacological therapy for GERD, in preterm infants with gestational age (GA) ≤34weeks. ...
Sadeck Lilian S R LS Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Electronic address: - - 2014
to analyze the effects of treatment approach on the outcomes of newborns (birth weight [BW] < 1,000g) with patent ductus arteriosus (PDA), from the Brazilian Neonatal Research Network (BNRN) on: death, bronchopulmonary dysplasia (BPD), severe intraventricular hemorrhage (IVH III/IV), retinopathy of prematurity requiring surgical (ROPsur), necrotizing enterocolitis requiring surgery (NECsur), ...
Wygnanski-Jaffe Tamara T The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer - - - 2014
To report the effect of oral propranolol on intraocular pressure (IOP) in infants newly diagnosed with unilateral Sturge-Weber syndrome (SWS) glaucoma receiving no other treatment. This was a prospective, nonrandomized interventional case series. Four infants presenting with unilateral SWS glaucoma with no prior treatment were treated with oral propranolol at ...
Herskind Anna A Department of Neuroscience and Pharmacology and Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; Helene Elsass Center, Charlottenlund, Denmark; Department of Neonatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, - - 2014
Infants with possible cerebral palsy (CP) are commonly assumed to benefit from early diagnosis and early intervention, but substantial evidence for this is lacking. There is no consensus in the literature on a definition of 'early', but this review focuses on interventions initiated within the first 6 months after term age. ...
Olds David L DL Department of Pediatrics, School of Medicine, University of Colorado, - - 2014
Mothers and children living in adverse contexts are at risk of premature death. To determine the effect of prenatal and infant/toddler nurse home visiting on maternal and child mortality during a 2-decade period (1990-2011). A randomized clinical trial was designed originally to assess the home visiting program's effect on pregnancy ...
Favrais Géraldine G Neonatal Intensive Care Unit (ICU), CHRU de Tours, Tours, - - 2014
Background: Over the last decades, considerable progress has been made in the perinatal management of high-risk preterm neonates, changing the landscape of pathological conditions associated with neurological impairments. Major focal destructive lesions are now less common, and the predominant neuropathological lesion is diffuse white-matter damage in the most immature infants. ...
Furuta Ken K Department of Obstetrics and Gynecology, Center for Perinatal Medicine, University of Miyazaki, Faculty of Medicine, Miyazaki, - - 2014
Among the causes of third trimester bleeding, the impact of placenta previa on cerebral palsy is not well known. To clarify the effect of maternal bleeding from placenta previa on cerebral palsy, and in particular when and how it occurs. A descriptive study. Sixty infants born to mothers with placenta ...
Vucovich Megan M MM Vanderbilt University Medical - - 2014
Sepsis is strongly associated with patency of the ductus arteriosus (PDA) in critically ill newborns. Inflammation and the aminoglycoside antibiotics used to treat neonatal sepsis cause smooth muscle relaxation, but their contribution to PDA is unknown. We examined whether: 1. Lipopolysaccharide (LPS) or inflammatory cytokines cause relaxation of the ex ...
Bethel James J Walsall Campus, University of Wolverhampton, West - - 2014
Incidents of scabies are increasing nationally and globally, particularly among certain vulnerable groups. This article examines a rare and unusual case of scabies infestation in infancy and highlights the importance of recognising the differences in presentation of infestation in infants to enhance early diagnosis and treatment.
Canty Wendy B WB Wendy B. Canty practices thoracic surgery at Brigham and Women's Hospital in Boston, Mass., and is a recent graduate of the Quinnipiac University PA program. Dawn Columb-Lippa is a professor in the PA program at Quinnipiac University in Hamden, Conn. The authors have disclosed no potential conflicts of interest, financial or - - 2014
Bronchiolitis is the most common lower respiratory tract infection in young children and the leading cause of infant hospitalizations. Treatment is centered on supportive measures. Recent studies suggest hypertonic saline is an effective treatment option in admitted infants, demonstrating promising reductions in length of stay and clinical severity scores.
Bawazeer Manal M Department of Pediatric, King Abdulaziz Medical City, Riyadh, Saudi - - 2014
This study investigated the effect of combining oral dexamethasone with either nebulized racemic epinephrine or salbutamol compared to bronchodilators alone for the treatment of infants with bronchiolitis. This was a double-blind, randomized controlled trial on infants (1 to 12 months) who were diagnosed in the emergency department with moderate-to-severe bronchiolitis. ...
Steiner M M Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Vienna, - - 2014
Background: Intravenous sildenafil treatment has recently shown promising results and good tolerability in the treatment of refractory pulmonary hypertension (PH) in term and near-term neonates, while comparable data in preterm infants are still lacking. However, for critically ill preterm infants suffering from PH refractory to conventional treatment, sildenafil may represent a ...
Wachman Elisha M EM Pediatrics, Boston Medical Center, Boston, MA. Electronic address: - - 2014
Neonatal abstinence syndrome (NAS) from in utero opioid exposure is highly variable with genetic factors appearing to play an important role. Epigenetic changes in cytosine:guanine (CpG) dinucleotide methylation can occur after drug exposure and may help to explain NAS variability. We correlated DNA methylation levels in the mu-opioid receptor (OPRM1) ...
Axelsson Paul Bryde PB Gynækologisk-Obstetrisk Afdeling, Nordsjællands Hospital, Dyrehavevej 29, 3400 Hillerød, Denmark. - - 2014
Breast milk has many advantages over formula for infants in developed and developing countries alike. Despite intentions of breastfeeding, some women develop insufficient lactation. Treatment options traditionally include breastfeeding education and pharmacotherapy. An electronic questionnaire regarding treatment of insufficient lactation was sent to all obstetric departments (n = 21) and ...
Woodacre Timothy T Royal Devon and Exeter Hospital, Barrack Road, Exeter, Devon, EX2 5DW, UK, - - 2014
Debate currently exists regarding the economic viability for screening for developmental dysplasia of the hip in infants. A prospective study of infant hip dysplasia over the period of 1998-2008 (36,960 live births) was performed to determine treatment complexity and associated costs of disease detection and hospital treatment, related to the ...
Aihara Yasuo Y Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan, - - 2014
The growing number of infants with deformational plagiocephaly (DP) has raised clinical questions about which children, at what age, and how molding helmet therapy (MHT) should be performed especially in Japan. A total of 1,011 Japanese pediatric head deformity infants had undergone MHT after being diagnosed with non-synostotic DP. Three ...
Miura Yuichiro Y Departments of *Neonatology †Radiology ‡Clinical Pathology §Maternal and Fetal Medicine, Miyagi Children's Hospital ∥Department of Maternal and Fetal Medicine, Tohoku University Graduate School of Medicine, Sendai, - - 2014
Reports of hepatoblastoma (HB) in preterm infants are quite rare. Herein, we report the clinical management of a preterm infant with inoperable congenital HB. A female fetus that had been diagnosed with a large liver tumor consistent with hemangioma was delivered by emergency cesarean section at 33 weeks of gestation ...
Murray Aisling A Economic and Social Research Institute, Dublin, Ireland, - - 2014
The Growing Up in Ireland Infant Cohort dataset (n = 11,134) includes information on fertility treatments for over 400 infants. IVF (28.1 %) and IVF-related treatments (17.8 %) were the most frequent, but there was also a high percentage following clomiphene citrate alone (31.5 %). Infants born following fertility treatment were much more likely to ...
Li Zhuoyang Z National Perinatal Epidemiology and Statistics Unit, The University of New South Wales, Sydney 2031, - - 2014
What is the standard of birthweight for gestational age for babies following assisted reproductive technology (ART) treatment? Birthweight for gestational age percentile charts were developed for singleton births following ART treatment using population-based data. Small for gestational age (SGA) and large for gestational age (LGA) births are at increased risks ...
Phillips Roderic J RJ Vascular Biology, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Paediatrics, Monash University, Melbourne, Victoria, - - 2014
To describe the clinical and histopathological characteristics of infantile haemangiomas that failed treatment with oral propranolol . This study is a case series from the vascular birthmarks clinic at Royal Children's Hospital, Melbourne. The patients for this study were infants who commenced treatment with oral propranolol before 6 months of ...
Heuchan Anne Marie AM Department of Neonatology, Royal Hospital for Sick Children, Glasgow, - - 2014
Optimal management of the patent ductus arteriosus (PDA) in the premature infant remains controversial. Despite considerable historical and physiological data indicating that a persistent PDA may be harmful, robust evidence of long-term benefits or harms from treatment is lacking. This has been equated to a lack of benefit but is ...
Rac Martha W F MW Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: - - 2014
To evaluate ultrasound findings of fetal syphilis and describe their progression after maternal treatment. This is a retrospective cohort study from September 1981 to June 2011 of seropositive women after 18 weeks of gestation who had an ultrasound prior to treatment to evaluate for fetal syphilis. Only those women receiving ...
Pérez Martínez E E Pediatric Department, Hospital Sant Joan de Déu, Barcelona, - - 2014
Subcutaneous fat necrosis (SCFN) is a rare entity that occurs generally in term or post-term newborns exposed to perinatal stressing factors. These cutaneous lesions appear during the first weeks of life and their potential complications, such as hypercalcemia, determine the prognosis. We present a full-term newborn with SCFN lesions that ...
Slusher Tina M TM Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota;Hennepin County Medical Center, Minneapolis, Minnesota; - - 2014
Evaluate safety and efficacy of filtered-sunlight phototherapy (FS-PT).METHODS: Term/late preterm infants ≤14 days old with clinically significant jaundice, assessed by total bilirubin (TB) levels, were recruited from a maternity hospital in Lagos, Nigeria. Sunlight was filtered with commercial window-tinting films that remove most UV and significant levels of infrared light ...
Galinsky Robert R Department of Physiology, University of Auckland, Auckland, New - - 2014
There is an important unmet need to further improve the outcome of neonatal encephalopathy in term infants. Meta-analyses of large controlled trials now suggest that maternal magnesium sulfate (MgSO4) therapy is associated with a reduced risk of cerebral palsy and gross motor dysfunction after premature birth, but that it has ...
Bajčetić Milica M *Clinical Pharmacology Unit, University Children's Hospital Belgrade, and Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Belgrade, Serbia; ‡IChTM, University of Belgrade, Belgrade, Serbia; §Institute for Multidisciplinary Research, University of Belgrade, Belgrade, - - 2014
Neonatal sepsis is one of the most fulminating conditions in neonatal intensive care units. Anti-pathogen and supportive care are administered routinely, but do not deliver satisfactory results. In addition, the efforts to treat neonatal sepsis with anti-inflammatory agents have generally shown to be futile. The accumulating data imply that intracellular ...
Oymar Knut - - 2014
Continuous positive airway pressure (CPAP) is commonly used to relieve respiratory distress in infants with bronchiolitis, but has mostly been studied in an intensive care setting. Our prime aim was to evaluate the feasibility of CPAP for infants with bronchiolitis in a general paediatric ward, and secondary to assess capillary ...
Czaba-Hnizdo Christine C Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, - - 2014
The aim of this study was to measure the brain activity of preterm infants treated with caffeine citrate and doxapram for preterm apnea, using amplitude-integrated electroencephalography (aEEG), to identify any adverse effects on cerebral function. We analysed the aEEG tracings of 13 preterm infants < 30 weeks of gestation before, ...
Ramzan Mohammed M Pediatric Hematology Oncology and BMT Unit, Department of Pediatrics, Fortis Memorial Research Institute, Gurgaon, Haryana, India. Correspondence to: Dr Satya P Yadav, Department of Pediatrics, Fortis Memorial Research Institute, Gurgaon, Haryana, India. - - 2014
Isolated mediastinal involvement in Langerhans cell histiocytosis (LCH) has been rarely reported. A 3-month-old boy presented with history of low grade intermittent fever, cough and noisy breathing for 2 weeks. A chest X-ray showed massive mediastinal widening. Biopsy of the mass confirmed LCH. Patient is doing well after one year ...
Vesoulis Zachary A ZA Washington University School of Medicine, St. Louis, MO, 63110, - - 2014
Seizures are more common in the neonatal period than any other time in the human lifespan. A high index of suspicion for seizures should be maintained for infants who present with encephalopathy soon after birth, have had a stroke, central nervous system (CNS) infection or intracranial hemorrhage or have a ...
Martin Nicole G NG Kennesaw State University, Kennesaw, GA 30144, United States. Electronic address: - - 2014
Referential specificity and affect specificity were examined in 12- to 14-month-olds (n=20), and 16- to 18-month-olds (n=20). Infants were presented with a televised social referencing paradigm involving an actress who emoted a simple descriptive message to one of two objects appearing on the video. The actress altered her affective message ...
Tanriverdi Sema S Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Ege University, Bornova, 35100, Izmir, Turkey, - - 2014
Studies about the effects of inhaled nitric oxide (iNO) on bleeding time and platelet aggregation in newborns are limited in number and have inconclusive results. Thromboelastogram (TEG) shows the combined effects of coagulation factors and platelet functions. In this preliminary study, we aimed to evaluate the effects of iNO on ...
Demirel Nihal N Department of Neonatology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, - - 2014
Background: Retinopathy of prematurity (ROP) is a significant cause of childhood blindness. Aim: The aim of this study is to determine the feasibility of remifentanil analgesia during laser treatment of ROP performed in the neonatal intensive care unit (NICU). Patients and Methods: Remifentanil was infused continuously during the procedure starting with a dose ...
Siriratsivawong Rick - - 2014
We present the case of a preterm neonate who was born with respiratory distress and a papulovesicular rash that was diagnosed as congenital candidiasis (CC). The mother was asymptomatic. The cutaneous eruption and respiratory distress improved following treatment with systemic antifungals. Congenital candidiasis ranges in presentation from isolated cutaneous involvement ...
Ozgun Uygur U Department of Pediatrics, Division of Neonatology, Ege University, Faculty of Medicine, Izmir, - - 2014
Retinopathy of prematurity (ROP) is a serious problem of preterm infants which may lead to impairment of vision and even to blindness if untreated. Routine eye examination is necessary for early diagnosis and treatment of ROP in preterm infants. Mydriatic eye drops (cyclopentolate, tropicamide and phenylephrine) are applied before the ...
Keating Brad - - 2014
This case was one that would put many EMS personnel out of their comfort zones. The presentation of an unstable child is enough to have some providers put on their blinders and focus solely on the respiratory causes and overlook the cardiac. This child had been unstable most of the ...
Ezeaka Chinyere V - - 2014
Timely and appropriate treatment of severe neonatal jaundice (NNJ) is crucial for preventing the associated morbidity and neuro-developmental sequelae. Since mothers are likely to be the first to observe the onset of severe illness in their newborns, we set out to identify the pattern and predictors of maternal care-seeking practices ...
Tunc Turan T Department of Pediatrics, Division of Neonatology, Gulhane Military School of Medicine, Ankara, - - 2014
Abstract Objective: Neonatal sepsis remains a major cause of morbidity and mortality in newborns. The chemokine CXCL12 and its receptor CXCR4 are now known to play an important role in inflammatory states. However, it's unclear how chemokines respond to late-onset neonatal sepsis. Methods: Patients were classified into the groups of ...
Neu Madalynn M 1 University of Colorado College of Nursing , Aurora, - - 2014
Abstract Objectives: To examine whether maternal-child interaction during feedings was suboptimal in dyads in which the infant had gastroesophageal reflux disease (GERD) and to compare massage therapy to a nonmassage therapy sham treatment in improving the mother-child interaction in these dyads. Design: In this randomized, controlled pilot study, infants received ...
Peters Babette B Emma Children's Hospital/AMC - Pediatrics, Meibergdreef 9, Amsterdam 1105 AZ, The - - 2014
Infantile hypertrophic pyloric stenosis (IHPS) is a common condition in infancy, characterized by an acquired narrowing of the pylorus, which requires surgery. These infants usually present with projectile, nonbilious vomiting, with a palpable 'olive' in the abdomen and sometimes a 'peristaltic wave' after being fed with formula or breast milk. ...
Haabrekke Kristin Johanne - - 2014
Abstract Aims There is a growing documentation that infants exposed to opioids and poly-substances prenatally have an increased risk of aberrant development. In Norway there are several in-patients-clinics that specialize in medically supervised detoxification for pregnant women with substance dependence in a therapeutic setting. As there is virtually no documentation ...
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