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- - 2013
Current practice guidelines recommend administration of surfactant at or soon after birth in preterm infants with respiratory distress syndrome. However, recent multicenter randomized controlled trials indicate that early use of continuous positive airway pressure with subsequent selective surfactant administration in extremely preterm infants results in lower rates of bronchopulmonary dysplasia/death ...
Kumar Praveen - - 2013
Nitric oxide, an important signaling molecule with multiple regulatory effects throughout the body, is an important tool for the treatment of full-term and late-preterm infants with persistent pulmonary hypertension of the newborn and hypoxemic respiratory failure. Several randomized controlled trials have evaluated its role in the management of preterm infants ...
Torrazza Roberto Murgas RM Division of Neonatology, Department of Pediatric, University of Florida College of Medicine, United - - 2013
Necrotizing enterocolitis (NEC) is an enigmatic disease that affects primarily premature infants. It often occurs suddenly and when it occurs, treatment attempts at treatment often fail and results in death. If the infant survives, there is a significant risk of long term sequelae including neurodevelopmental delays. The pathophysiology of NEC ...
Feltman Dalia D Neonatology Division, Evanston Hospital, Evanston, - - 2013
Doctors have no ethical obligation to provide futile treatment. This has been true since the time of Hippocrates who warned physicians not to treat patients who were "overmastered by their disease." This principle remains valid today but, as the Society for Critical Care Medicine notes, it is difficult to identify ...
Escobar Gabriel J GJ Regional Director for Hospital Operations Research, Kaiser Permanente Northern California, Division of Research, 2000 Broadway Ave, Oakland, CA 94612. - - 2014
To define a quantitative stratification algorithm for the risk of early-onset sepsis (EOS) in newborns ≥ 34 weeks' gestation. We conducted a retrospective nested case-control study that used split validation. Data collected on each infant included sepsis risk at birth based on objective maternal factors, demographics, specific clinical milestones, and ...
Moghaddam Mahsa Bidgoli MB The Hospital for Sick Children, Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, 555 University Ave, Toronto, ON M5G 1X8, - - 2013
Deformational plagiocephaly (DP) is a multifactorial non-synostotic cranial deformity with a reported incidence as high as 1 in 7 infants in North America. Treatment options have focused on non-operative interventions including head repositioning and the use of an orthotic helmet device. Previous studies have used linear and two dimensional outcome ...
Kluckow Martin - - 2013
Failure of closure of the patent ductus arteriosus (PDA) may be associated with harm. Early cardiac ultrasound-targeted treatment of a large PDA may result in a reduction in adverse outcomes and need for later PDA closure with no increase in adverse effects. Multicentre, double-blind, placebo-controlled randomised trial. Three neonatal intensive ...
Kulkarni Aniket D AD From the Women's Health and Fertility Branch, Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta (A.D.K., D.J.J., D.M.K., M.F.G.); the Johns Hopkins School of Medicine, Baltimore (H.W.J.); the Eastern Virginia Medical School, Norfolk (H.W.J.); the Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati (M.M.); and the Warren Alpert Medical School, Brown University, Providence, RI - - 2013
The advent of fertility treatments has led to an increase in the rate of multiple births in the United States. However, the trends in and magnitude of the contribution of fertility treatments to the increase are uncertain. We derived the rates of multiple births after natural conception from data on ...
Holmes Allison V - - 2013
A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve ...
Ramantani Georgia G Epilepsy Centre, University Hospital Freiburg, - - 2013
Neonatal seizures constitute the most common and distinctive sign of neurological dysfunction in the first weeks of life and reflect a wide variety of underlying central nervous system disorders. Acute symptomatic seizures occur more often during the neonatal period than at any period of life and are associated with adverse ...
Zattra E E Dermatology Unit, Department of Medicine University of Padua, Padua, Italy - - - 2013
Transient symptomatic zinc deficiency is a rare disorder clinically indistinguishable from acrodermatitis enteropathica characterized by periorificial and acral dermatitis that usually occurs in exclusively breast-fed infant especially if preterm. We describe a three-month-old breast-fed preterm boy who developed the typical skin lesions. Maternal breast milk zinc was lower than the ...
Kaparti Lavanya L Senior Resident, Department of Anaesthesiology, PESIMSR , Kuppam, India - - 2013
Neonates who are born with CDH suffer from sub-stantial morbidity and mortality. Modalities of treatment are said to influence outcome, apart from pre-natal and post-natal factors. Reports from developed countries have described improved survival with High Frequency Oscillatory Ventilation (HFOV), Extra Corporeal Membrane Oxygenation (ECMO) and inhaled Nitric Oxide (NO). ...
S Thabitha Rani TR Reader, Department of Pedodontics and Preventive Dentistry, Kamineni Institute of Dental Sciences , Narketpally, Nalgonda, India - - 2013
In infants with cleft lip and palate, failure to thrive (FTT) condition has largely been attributed to early feeding difficulties. Presurgical Nasoalveolar Molding (PNAM) forms an integral part of treatment modality for cleft infants in such conditions, by providing a myriad of benefits.It balances several aspects of treatment such as ...
Jacobs A A Charité - Universitätsmedizin Berlin, Klinik für Dermatologie, Berlin ; Bundesinstitut für Risikobewertung, Abteilung für Lebensmittelsicherheit, - - 2013
Breastfeeding is widely acknowledged to be the best and most complete form of nutrition for healthy infants born at term and is associated with numerous benefits in terms of infants' health, growth, immunity and development. However, breastfeeding problems often result in early weaning. Standardized treatment recommendations for breastfeeding-related diseases are ...
Rosen Rachel - - 2013
IMPORTANCE Rarely have the best methods of diagnosis or the treatment of a disease engendered more controversy than gastroesophageal reflux (GER), a highly prevalent condition in infants. OBJECTIVE To discuss the latest controversies in the diagnosis and treatment of GER in infants. EVIDENCE REVIEW All articles related to the diagnosis ...
Puligadda Ranjith K - - 2013
Most infantile hemangiomas resolve spontaneously without any need for therapy. However some hemangiomas require treatment to preserve function (vision, feeding and breathing) or to treat complications like ulceration, bleeding and scarring. The authors present a 5-mo-old infant with large orbital hemangioma on left side completely obscuring palpebral fissure, successfully managed ...
Corsini Iuri - - 2013
Abstract Pulmonary interstitial emphysema (PIE) is a frequent complication in preterm ventilated infants. These newborns have an increased risk of mortality and bronchopulmonary dysplasia. Various treatments for PIE have been proposed: high-frequency ventilation, postural therapy, selective bronchial intubation or surgery. We present an atypical case of a preterm infant with ...
Sørensen Holger J - - 2013
Background: Numerous studies on seasonality of birth and schizophrenia risk have been published but it is uncertain whether, among those with schizophrenia, refractory illness exhibits any predilection for birth month. We hypothesized and examined whether a season of birth effect was present in patients with schizophrenia with a history of ...
Kwon Dong Rak - - 2013
Objective:To compare the effects of a combination of therapeutic exercise and ultrasound with or without additional microcurrent therapy in infants with congenital muscular torticollis involving the entire sternocleidomastoid muscle.Design:Prospective, randomized, placebo-controlled trial.Setting:An outpatient rehabilitation clinic in a tertiary university hospital.Subjects:Infants (n = 20) with congenital muscular torticollis involving the entire ...
Anabrees Jasim - - 2013
Infantile colic is a common paediatric condition which causes significant parental distress. Increased intestinal coliform colonization in addition to alteration in Lactobacillus abundance and distribution may play an important role in its pathogenesis.The objectives of this systematic review are to evaluate the efficacy of probiotic supplementation in the reduction of ...
Binkiewicz-Glinska Anna - - 2013
Arthrogryposis multiplex congenita is an etiopathogenetically heterogeneous disorder characterised by non-progressive multiple intra-articular contractures, which can be recognised at birth. The frequency is estimated at 1 in 3,000 newborns. Etiopathogenesis of arthrogryposis is multifactorial. We report first 26 weeks of life of a boy with severe arthrogryposis. Owing to the ...
Dang Dan D Department of Neonatology, The First Hospital of Jilin University, Changchun, - - 2014
Harlequin color change is a benign transient skin change usually seen in the neonatal period with unknown etiology. It has been rarely reported in preterm infants. Herein, we report two cases of harlequin color change developed in premature infants without any adverse consequences. During the event, one infant was receiving ...
Joshi Kriti - - 2013
Vitamin D has an important role to play in skeletal and extraskeletal health. Inspite of being a sun rich country, India has widespread vitamin D deficiency. Vitamin D deficiency can lead to serious consequences like hypocalcemic seizures and increased risk of respiratory tract infections in neonates and infants. International expert ...
Maguire Denise J - - 2013
When women addicted to opioids seek prenatal care, the treatment of choice is methadone. Methadone mediates the addiction by reducing fluctuations in maternal serum opioid levels and protecting the fetus from repeated withdrawal episodes. Methadone maintenance is associated with increased maternal weight gain, decreased illegal drug use, and improved compliance ...
Subramaniam Sathyaseelan - - 2013
Scabies is commonly seen worldwide, in its usual classic form when afflicting older children and adults. However, neonatal scabies is described as its own entity in the literature. We present a case of a 4-week-old infant with a generalized papulopustular, vesicular, and crusted rash who was diagnosed with scabies. We ...
Matejcek Adela - - 2013
Question In my office I occasionally see neonates with conjunctivitis. What are the current recommendations for ocular prophylaxis at birth? Do topical antibiotics alone provide adequate treatment of neonatal conjunctivitis? When is systemic therapy indicated? Answer All infants should receive ocular prophylaxis at birth to prevent gonococcal ophthalmia. Neonates presenting ...
N Girish G Assistant Professor, Department of Pediatrics, Kempegowda Institute of Medical Sciences Hospital & Research Centre , Bangalore, India - - 2013
Introduction: Neonatal jaundice is the commonest abnormal physical finding in the new born nursery and hemolytic disease of the newborn (HDN) among babies born to Rh negative mothers is the most formidable etiology. During last few decades considerable evolution has been observed in this entity secondary to development of several ...
Vose Linnea R LR Departments of Pediatrics, and Cell Biology and Anatomy, Regional Neonatal Center, Maria Fareri Children's Hospital at Westchester Medical Center-New York Medical College, Valhalla, New York 10595, Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239, Department of Neuroscience, University of Connecticut, Farmington, Connecticut 06269, and Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Florida - - 2013
Intraventricular hemorrhage (IVH) remains a major cause of white matter injury in preterm infants with no viable therapeutic strategy to restore myelination. Maturation of oligodendrocytes and myelination is influenced by thyroid hormone (TH) signaling, which is mediated by TH receptor α (TRα) and TRβ. In the brain, cellular levels of ...
Siqveland Torill S - - 2013
The quality of mother-infant interaction during the first year may be hampered by maternal substance abuse and co-existing non-optimal factors such as psychiatric problems and difficult relational experiences. In the present study three groups of women were recruited during pregnancy: One group with substance abuse problems from residential treatment centers ...
Persaud Deborah D From the Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore (D.P., C.Z., Y.H.C.), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick (M.P.), and the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda (T.-W.C.) - all in Maryland; the Department of Pediatrics, University of Mississippi Medical Center, Jackson (H.G.); the University of California San Diego, La Jolla, and the Veterans Affairs San Diego Healthcare System, San Diego (M.S., D.R.); and the Department of Pediatrics, Program in Molecular Medicine, and Center for Clinical and Translational Science, University of Massachusetts Medical School, Worcester - - 2013
An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was ...
Dyson Jessica Katharine JK Liver Unit , Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne , - - 2014
Vertical transmission of the hepatitis B virus (HBV) is the commonest mode of infection and can be prevented with immunoprophylaxis of the infant and antiviral therapy in the mother. Our aim was to review a cohort of subjects with HBV in pregnancy to determine the prevalence of active disease or ...
Davis Ryan P RP Section of Pediatric Surgery, C.S. Mott Children's Hospital, University of Michigan Health Systems, Ann Arbor, - - 2013
Managing pulmonary issues faced by both term and preterm infants remains a challenge to the practicing pediatric surgeon. An understanding of normal fetal and neonatal pulmonary development and physiology is the cornerstone for understanding the pathophysiology and treatment of many congenital and acquired problems in the neonate. Progression through the ...
Mitra Souvik - - 2013
Patent ductus arteriosus (PDA) in preterm infants is a controversial topic in the management of preterm neonates. There are no generally accepted guidelines for diagnosis, treatment, and follow-up of PDA, and few publications have covered the whole topic or have been conclusively summarized to give a proper direction for the ...
Lopez Emmanuel - - 2013
Surfactant therapy is one of the few treatments that have dramatically changed clinical practice in neonatology. In addition to respiratory distress syndrome (RDS), surfactant deficiency is observed in many other clinical situations in term and preterm infants, raising several questions regarding the use of surfactant therapy.Objectives: This review focuses on ...
Manley Brett J BJ Newborn Research Centre, Royal Women's Hospital, Melbourne, VIC, Australia. - - 2013
The use of high-flow nasal cannulae is an increasingly popular alternative to nasal continuous positive airway pressure (CPAP) for noninvasive respiratory support of very preterm infants (gestational age, <32 weeks) after extubation. However, data on the efficacy or safety of such cannulae in this population are lacking. In this multicenter, ...
Ganeshalingham Anusha - - 2013
Anaerobic meningitis in infants is rare, therefore a high index of clinical suspicion is essential as routine methods for processing cerebrospinal fluid (CSF) do not detect anaerobes and specific antimicrobial therapy is required. We present an infant with Escherichia coli meningitis where treatment-resistance developed in association with culture negative purulent ...
Verma Nishant - - 2013
Bronchiolitis is one of the major causes for hospital admissions in infants. Managing bronchiolitis, both in the outpatient and inpatient setting remains a challenge to the treating pediatrician. The effectiveness of various interventions used for infants with bronchiolitis remains unclear. To evaluate the evidence supporting the use of currently available ...
Chen Xin-Chun - - 2013
The most common cause of facial palsy is idiopathic or Bell's palsy. Although uncommon in the postantibiotic era, otomastoiditis should receive more attention as a cause of facial palsy, especially in young children. Delay of identification and treatment may result in permanent neurological sequelae. To describe a 3-month-old infant eventually ...
Mactier Helen - - 2013
Substance misuse in pregnancy is not a new problem, but although impaired foetal growth and the risk of developing neonatal abstinence syndrome are widely appreciated, relatively little attention has been paid to longer term consequences for the infant. Available evidence indicates that prenatal exposure to opioids and other drugs of ...
Wei Shu-Hao - - 2013
Few clinical studies have assessed the efficacy and safety of oxcarbazepine (OXC) oral suspension in Asian pediatric patients and particularly in infants. The aim of this study was to investigate and compare the efficacy, tolerability, and side effects of OXC oral suspension in Taiwanese infants and children with various types ...
Sandal G - - 2013
Evidence that oxidative stress plays a role in the development of bronchopulmonary dysplasia (BPD). There is a close relationship between oxidative stress and inflammation. In this study, it is aimed to investigate influences of hydrocortisone used in the treatment of BPD on anti-oxidant system in preterm infants with BPD. The ...
Jasani B B Department of Neonatology, Seth GS Medical College and KEM Hospital, Acharya Donde Marg, Parel, Mumbai, Maharashtra, - - 2013
We herewith report a case series of six premature neonates with hemodynamically significant paten ductus successfully treated with oral paracetamol. This is a first case series describing the use of oral paracetamol treatment patent ductus in preterm neonates from India. Further prospective randomized-controlled trials are needed to evaluate the efficacy ...
Gerull Roland - - 2013
To compare treatment strategies for respiratory failure in extremely low birth weight (ELBW) infants in Germany in 1997 to Germany, Austria and Switzerland in 2011. A detailed questionnaire about treatment strategies for ELBW infants was sent to all German centres treating ELBW infants in 1997. A follow-up survey was conducted ...
Pritham Ursula A - - 2013
To review the literature about the association between breastfeeding and neonatal abstinence syndrome (NAS) severity, need for pharmacologic treatment for NAS, and length of hospital stays in neonates with in-utero exposure to methadone or buprenorphine opioid replacement therapy. PubMed, CINAHL, and Medline were searched for articles published between January 1990 ...
Makadia Darshak - - 2013
Autoimmune hemolytic anemia (AIHA) is an immune mediated destruction of erythrocytes, which has a good prognosis in children. It is known to have chronic, remitting or relapsing course, especially in infants and adolescents. Treatment of refractory or relapsing AIHA is a challenge as the other aim of the treatment is ...
Olukman O - - 2013
Nemaline myopathy (NM) is a genetically and clinically heterogeneous muscle disorder, defined by the presence of characteristic nemaline bodies on muscle biopsy. The disease has a wide spectrum of phenotypes, ranging from forms with neonatal onset and fatal outcome to asymptomatic forms. The neonatal form is severe and usually fatal. ...
Richerson George B GB Departments of Neurology and Molecular Physiology & Biophysics, University of Iowa, Veteran's Affairs Medical Center, Iowa City, - - 2013
Sudden unexpected death in epilepsy (SUDEP) is an exceptionally difficult condition to study in humans. Therefore, translational research in animal models has been very important in defining pathophysiological mechanisms of death and identifying potential treatments. These models are helping define whether the primary mechanism of death is cardiac or respiratory. ...
Erdinç Kemal K Gülhane Military Academy of Medicine, Department of Pediatrics, Ankara, - - 2013
Herein we report an asphyctic preterm neonate with respiratory distress and prothrombotic risk factors that responded positively to rtPA treatment following 2 attacks of acute thrombosis. Conflict of interest:None declared.
- - 2013
In resource-limited settings, most young infants with signs of severe infection do not receive the recommended inpatient treatment with intravenous broad spectrum antibiotics for 10 days or more because such treatment is not accessible, acceptable or affordable to families. This trial was initiated in the Democratic Republic of Congo, Kenya ...
Esamai Fabian F Department of Child Health and Paediatrics, School of Medicine, Moi University, Eldoret, - - 2013
The current World Health Organization (WHO) recommendation for treatment of severe infection in young infants is hospitalization and parenteral antibiotic therapy. Hospital care is generally not available outside large cities in low- and middle-income countries and even when available is not acceptable or affordable for many families. Previous research in ...
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