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Kaditis Athanasios G AG Paediatric Pulmonology and Allergy Units, Sleep Disorders Laboratory, First Department of Paediatrics, National and Kapodistrian University of Athens, School of Medicine and Aghia Sophia Children's Hospital, Athens, - - 2014
This study aimed to demonstrate that viral bronchiolitis is associated with intermittent oxygen saturation of haemoglobin (SpO2 ) drops (≥ 3%) and low basal SpO2 between episodes of haemoglobin desaturation. Infants with bronchiolitis underwent pulse oximetry during the first night following hospital admission and a subgroup of them underwent repeat ...
Barber Joy L JL Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK, WC1N - - 2014
Aim of this study was to investigate whether lung assessment on post-mortem magnetic resonance imaging (PMMR) can reliably differentiate between live birth and stillbirth. We retrospectively assessed PMMR imaging features of a group of late foetal terminations following fetocide and stillbirths (without witnessed breathing) and early infant deaths (breathed spontaneously ...
Assaf Santiago J SJ James Whitcomb Riley Hospital for Children Department of Pediatrics, Sections of Pulmonology, Indiana University School of Medicine, Indianapolis, - - 2014
Rationale: While infants who are born extremely premature and develop bronchopulmonary dysplasia (BPD) have impaired alveolar development and decreased pulmonary diffusion (DLCO ), it remains unclear whether infants born less premature and do not develop BPD, healthy premature (HP), have impaired parenchymal development. In addition, there is increasing evidence that ...
Eriksson Lena L Centre for Pharmacoepidemiology and, Unit of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet, 17176, Stockholm, Sweden; Medical Products Agency, 75103, Uppsala, - - 2014
Bronchopulmonary dysplasia (BPD) is a frequent chronic lung disease in preterm infants and we aimed to identify factors associated with this condition in infants with respiratory distress syndrome (RDS). This case-control study, using national Swedish data, included 2,255 preterm infants, born before 33 gestational weeks. The 667 BPD cases were ...
Mullowney Tara T Divisions of Respiratory Medicine and Departments of Post Graduate Medical Education - - 2014
Primary ciliary dyskinesia (PCD) is a rare inherited disease affecting motile cilia lining the respiratory tract. Despite neonatal respiratory distress as an early feature, diagnosis is typically delayed until late childhood. Our objective was to identify characteristics that differentiate PCD from common causes of term neonatal respiratory distress. This was ...
Poli Jonathan A JA Center for Developmental Therapeutics, Seattle Children's Hospital Research Institute, Seattle, Washington. - - 2014
High-frequency pressure oscillations created by gas bubbling through an underwater seal during bubble CPAP may enhance ventilation and aid in lung recruitment in premature infants. We hypothesized that there are no differences in the magnitude of oscillations in lung volume (ΔV) in a preterm neonatal lung model when different bubble ...
Mola Sara J SJ Department of Pediatrics, Division of Neonatology, University of Maryland School of Medicine, Baltimore, Maryland; - - 2014
The objective of this study was to investigate whether a respiratory care bundle, implemented through participation in the Vermont Oxford Network-sponsored Neonatal Intensive Care Quality Improvement Collaborative (NIC/Q 2005) and primarily dependent on bedside caregivers, resulted in sustained decrease in the incidence of bronchopulmonary dysplasia (BPD) in infants < 30 ...
Uberos J J Pediatric Service. Clinical Hospital San Cecilio. Avda. Dr. Oloriz 16, 18012 Granada, Spain - - - 2014
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects premature infants with multifactorial etiology. Some authors have considered malnutrition to be a major factor promoting BDP. The aim of our study was to examine the contribution of enteral and parenteral nutritional intake in the first 14 days of life ...
Chen Liang-Wan LW Department of Cardiac Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian, - - 2014
Recently, the superior approach with transaction of the superior vena cava was introduced for the repair of supracardiac anomalies in adults. We developed a bidirectional right-angle venous cannula and placed it within the innominate vein to make the modified superior approach with the superior caval transection suitable for neonates and ...
Grazioli Serge S Neonatal and Pediatric Intensive Care Unit, University Hospital of Geneva, - - 2014
Several new generation neonatal ventilators that incorporate conventional as well as high frequency ventilation (HFOV) have appeared on the market. Most of them offer the possibility to use HFOV in a volume-targeted mode, despite absence of any preclinical data. With a bench test, we evaluated the performances of 4 new ...
Lusk Leslie A LA Division of Neonatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA. Electronic address: - - 2014
To describe the natural history of pulmonary hypertension (PH) and the risk of death and pulmonary morbidity associated with the persistence of PH through the neonatal hospitalization for these infants. We performed a retrospective cohort study of infants with congenital diaphragmatic hernia (CDH) cared for at University of California San ...
Premnath Daphne D Department of Internal Medicine, Canberra Hospital, Garran, ACT, - - 2014
Abstract Objective: To compare two treatment strategies in preterm infants with or at risk of respiratory distress syndrome: early surfactant administration (within one hour of birth) vs. late surfactant administration, in a geographically defined population. Outcome: The primary outcome was chronic lung disease (CLD) and mortality before/at 36 weeks. Secondary ...
Caminita Frank F Draeger Medical - - 2014
Respiratory distress syndrome (RDS) and bronchopulmonary dysplasia remain the leading causes of preterm infant morbidity, mortality, and lifelong disability. Research to improve outcomes requires translational large animal models for RDS. Preterm pigs delivered by caesarian section at gestation days (GD) 98, 100, 102, and 104 days were provided 24 h ...
Gkentzi Despoina - - 2014
Late preterm infants are defined as those born between 34(0/0) and 36(6/7) weeks of gestation. This population represents a growing proportion of preterm deliveries and traditionally has been neglected as thought to behave similarly to term infants. However, studies in the last decade have shown that they are vulnerable not ...
Mourani Peter M PM University of Colorado Denver, Pediatrics, Aurora, Colorado, United States, University of Colorado School of Medicine, Pediatrics, Aurora, Colorado, United States ; - - 2014
Rationale: Pulmonary hypertension (PH) is associated with poor outcomes among preterm infants with bronchopulmonary dysplasia (BPD), but whether early signs of pulmonary vascular disease are associated with the subsequent development of BPD or PH at 36 weeks post menstrual age (PMA) is unknown. Objective: To prospectively evaluate the relationship of ...
Friedman Frederick F Jr Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine, Mount Sinai, New York, NY, USA - - 2014
Sudden unexpected neonatal collapse in the delivery room is a rare occurrence in healthy term infants. Upper airway obstruction may occur from improper positioning of the newborn even while breastfeeding. Such occlusion may have dire consequences if not recognized immediately. We report 2 healthy term neonates who suffered respiratory arrest ...
McAdams Ryan M RM Department of Pediatrics, University of Washington, Seattle, Washington. Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington. - - 2014
Respiratory distress is a leading cause of neonatal death in low-income and middle-income countries. CPAP is a simple and effective respiratory support modality used to support neonates with respiratory failure and can be used in low-income and middle-income countries. The goal of this study was to describe implementation of the ...
Li Xue X Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing, China. Correspondence to: Dr Yuan Shi, Director and Professor, Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing, 400 042, China. - - 2014
To assess the efficacy of nasal intermittent positive pressure ventilation with heliox in preterm infants with respiratory distress syndrome. Premature infants with mild respiratory distress syndrome requiring non-invasive respiratory support were eligible. Infants were randomly assigned to heliox or air-oxygen group. The main outcome was the length of ventilation. Heliox ...
Neumann Roland P RP Department of Neonatology, University Children's Hospital Basel (UKBB), Basel, - - 2014
Background: Ventilated preterm infant lungs are vulnerable to overdistension and underinflation. The optimal ventilator-delivered tidal volume (VT) in these infants is unknown and may depend on the extent of alveolarisation at birth. Objectives: We aimed to calculate respiratory dead space (VD) from the molar mass (MM) signal of an ultrasonic ...
Ambalavanan Namasivayam N Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL. Electronic address: - - 2014
To identify single-nucleotide polymorphisms (SNPs) and pathways associated with bronchopulmonary dysplasia (BPD) because O2 requirement at 36 weeks' postmenstrual age risk is strongly influenced by heritable factors. A genome-wide scan was conducted on 1.2 million genotyped SNPs, and an additional 7 million imputed SNPs, using a DNA repository of extremely low ...
Brumbaugh Jane E JE Stead Family Department of Pediatrics, the Department of Obstetrics and Gynecology, and the College of Liberal Arts and Sciences, University of Iowa, Iowa City, - - 2014
To evaluate neonatal survival after prolonged preterm premature rupture of membranes (PROM) in the era of antenatal corticosteroids, surfactant, and inhaled nitric oxide. A single-center retrospective cohort study of neonates born from 2002-2011 after prolonged (1 week or more) preterm (less than 24 weeks of gestation) rupture of membranes was ...
Maheshwari Rajesh R New South Wales Newborn and Paediatric Emergency Transport Service, Westmead, New South Wales, Australia. Electronic address: - - 2014
The objective was to evaluate the respiratory management of neonates of 23 to 26 weeks' gestation transported after birth outside a tertiary center. Another objective was to collect data regarding survival, intraventricular hemorrhage (IVH), and chronic lung disease. This was a retrospective study of transports from a statewide dedicated neonatal ...
Bass W Thomas WT Department of Pediatrics, Division of Neonatal Medicine, Children's Hospital of The King's Daughters, Children's Specialty Group, Eastern Virginia Medical School, Norfolk, - - 2014
Capnocytophaga is an opportunistic gram-negative anaerobic bacillus found in the oropharyngeal cavity of mammals and is associated with periodontal disease in humans. Sepsis, osteomyelitis, lung abscess, endocarditis, and meningitis have been reported in humans following animal bites. Perinatal infection with Capnocytophaga is infrequent and is generally considered to have a ...
Siaghani Parwizjohn P a UCI MEDICAL CENTER, - - 2014
Abstract Infantile hemangiomas are the most common benign neoplasm of infancy, the majority occurring on the head and neck region. Predisposing factors include prematurity, low birth weight, multiple gestations, advanced maternal age, and chorionic villous sampling. In addition, Caucasians females particularly those with a known family history are also at ...
Sameshima Yoshino Tamaki YT *Pediatric Radiology, †Pediatric Intensive Care Unit, and ‡Diagnostic Imaging Department, Hospital Israelita Albert Einstein, São Paulo, - - 2014
The reversal of lung collapse is one of the challenges of lung injury prevention in pediatric acute respiratory distress syndrome. In this case, lung recruitment maneuver (RM) with positive end-expiratory pressure under computed tomography guidance is the procedure of choice, but cumulative ionizing radiation exposure is a major radiologic concern, ...
Gnanendran Lokiny L Department of Medicine, Canberra Hospital, Garran, Australian Capital Territory, - - 2014
To study the neurodevelopmental outcomes of multiple (twins, triplets, quads) compared with singleton extremely preterm infants <29 weeks gestation. Population-based retrospective cohort study. A network of 10 neonatal intensive care units in a geographically defined area of New South Wales and the Australian Capital territory. 1473 infants <29 weeks gestation born between ...
D'Angio Carl T CT URMC - - 2014
Bronchopulmonary dysplasia (BPD) is an important lung developmental pathophysiology that affects many premature infants each year. Newborn animal models employing both premature and term animals have been used over the years to study various components of BPD. This review describes some of the neonatal rabbit studies that have contributed to ...
Agarwal R R Carman and Ann Adams Department of Pediatrics, Wayne State University, Hutzel Women's Hospital & Children's Hospital of Michigan, Detroit, MI, - - 2014
Persistent pulmonary hypertension of the newborn (PPHN) results from disruption of the normal fetal-neonatal circulatory transition and may be associated with meconium aspiration, group B streptococcal sepsis, pneumonia, respiratory distress syndrome, congenital diaphragmatic hernia and pulmonary hypoplasia. Seventeen percent of cases are considered idiopathic since there is no identifiable cause. ...
Puder Lia C - - 2014
Several respiratory diseases are associated with specific respiratory sounds. In contrast to auscultation, computerized lung sound analysis is objective and can be performed continuously over an extended period. Moreover, audio recordings can be stored. Computerized lung sounds have rarely been assessed in neonates during the first year of life. This ...
la Grange Heleen H Division of Medical Virology, Department of Pathology, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa. Electronic address: - - 2014
Currently in South Africa research into sudden unexpected death in infancy (SUDI) is limited. The causes of sudden infant death syndrome (SIDS) remain obscure despite full medico-legal investigations inclusive of autopsy, scene visit and ancillary studies. Viral infections play an important role as a multitude of respiratory viruses have been ...
Janér Cecilia C Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, - - 2014
Background: Respiratory distress due to inadequate lung liquid clearance is a significant problem in infants delivered late preterm or early term, especially by elective cesarean delivery (CD). Lung liquid clearance depends on epithelial ion transport and in animals is induced by glucocorticoids. Objectives: In newborn late preterm and term infants ...
Bozdağ Senol S Department of Neonatology, Umraniye Research and Training Hospital, İstanbul, - - 2014
Objective To compare the efficacy of two natural surfactants for pulmonary hemorrhage in very low-birth-weight (VLBW) infants. Study Design A prospective randomized controlled trial was conducted on 42 infants who were divided into two groups, poractant alfa (n = 21) and beractant (n = 21). Results In both the groups, the mean standard deviation (SD) birth-weight and ...
van Vonderen Jeroen J JJ Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The - - 2014
Upper airway distention during mask ventilation could reduce gas volumes entering the lung compared with ventilation via an endotracheal tube. Therefore, respiratory tract volumes were measured in lambs and tidal volumes were compared in preterm infants before and after intubation. Design: In seven preterm lambs, volumes of the airways (oropharynx, ...
Nagiub Mohamed M Division of Pediatric Cardiology, Department of Pediatrics, Children Hospital of Richmond, Virginia Commonwealth University, Richmond, - - 2014
As survival and outcomes continue to improve in neonates born prematurely, there is an increasing need to promptly identify and treat pulmonary hypertension (PHT) in this population. Several echocardiographic indices have been used to evaluate for PHT. There is no clear consensus on how to utilize these parameters specifically for ...
Tolia Veeral N VN Pediatrix Medical Group, Baylor Health Care System, Dallas, - - 2014
Prophylactic vitamin A supplementation has been shown to reduce the incidence of chronic lung disease or death in extremely low-birth-weight infants. Beginning in 2010, a national shortage reduced the supply of vitamin A available. To estimate the association between vitamin A supplementation and death or chronic lung disease in the ...
Ashmeade Terri L TL University of South Florida Morsani College of Medicine, Tampa, FL - - 2014
The objective of this study was to implement and evaluate a quality improvement project (the golden hour pathway [GHP]) aimed at improving the quality and efficiency of care delivered to extremely low birth weight (ELBW) infants <28 weeks gestation and/or <1000 g birth weight during the first hour of life. ...
Gibson Anne-Marie AM Murdoch Children's Research Institute, Melbourne, Victoria, Australia; University of Melbourne, Melbourne, Victoria, - - 2014
The lung function outcome of cohorts of very low birth weight (VLBW; birth weight <1501 g) survivors born in the late 1970s or early 1980s into adulthood at an age when lung growth would be expected to have ceased is not well described. The aim of this study was to report ...
Lemyre Brigitte B Division of Neonatology, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, Canada, KlH - - 2014
Previous randomised trials and meta-analyses have shown nasal continuous positive airway pressure (NCPAP) to be a useful method of respiratory support after extubation. However, infants managed in this way sometimes 'fail' and require endotracheal reintubation with its attendant risks and expense. Nasal intermittent positive pressure ventilation (NIPPV) is a method ...
Losty Paul D PD Department of Paediatric Surgery, Alder Hey Children׳s Hospital NHS Foundation Trust, University of Liverpool, Liverpool, UK. Electronic address: - - 2014
Congenital diaphragmatic hernia (CDH) retains high mortality and morbidity due to lung hypoplasia, pulmonary hypertension and severe co-existent anomalies. This article offers a comprehensive state-of-the-art review for the paediatric surgeon whilst also describing key contributions from the basic sciences in the search to uncover the cause of the birth defect ...
Thunqvist Per P Sachs' Children's Hospital, Department of Pediatrics, Södersjukhuset, 118 83, Stockholm, Sweden; Karolinska Institute, Department of Clinical Science and Education, 171 77, Stockholm, - - 2014
Many preterm infants with bronchopulmonary dysplasia (BPD) demonstrate impaired lung function and respiratory symptoms during infancy. The relationships between initial BPD severity, lung function and respiratory morbidity are not fully understood. We aimed to investigate the association between BPD severity and subsequent lung function and whether lung function impairment is ...
Callahan Patrick P Departments of Anesthesiology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, - - 2014
For the last thirty years, oral chloral hydrate has been used for sedation of infants for lung function testing. Recently, however, availability of chloral hydrate became severely limited in the United States after two manufacturers discontinued manufacturing in 2012. Due to these limitations and the recent and ongoing shortage of ...
Raimondi Francesco F Division of Neonatology, Section of Pediatrics, Department of Translational Medical Sciences, and - - 2014
Noninvasive ventilation is the treatment of choice for neonatal moderate respiratory distress (RD). Predictors of nasal ventilation failure are helpful in preventing clinical deterioration. Work on neonatal lung ultrasound has shown that the persistence of a hyperechogenic, "white lung" image correlates with severe distress in the preterm infant. We investigate ...
Manzoni Paolo P Neonatology and NICU, S. Anna Hospital, Torino, Italy. Electronic address: - - 2014
The diagnosis of congenital CMV is usually guided by a number of specific symptoms and findings. Unusual presentations may occur and diagnosis is challenging due to uncommon or rare features. Here we report the case of two preterm, extremely low birthweight, 28-week gestational age old twin neonates with CMV infection ...
Thall Peter F PF Dept. of Biostatistics, M.D. Anderson Cancer Center, Houston, Texas, - - 2014
The Intubation-Surfactant-Extubation (INSURE) procedure is used worldwide to treat pre-term newborn infants suffering from respiratory distress syndrome, which is caused by an insufficient amount of the chemical surfactant in the lungs. With INSURE, the infant is intubated, surfactant is administered via the tube to the trachea, and at completion the ...
Arora Kamaldeep K Department of Pediatrics, Dayanand Medical College and Hospital, Ludhiana, Punjab, 141001, - - 2014
Pneumothorax, though rare, is a recognized cause of respiratory distress in the immediate newborn period. It may occur spontaneously or secondary to various underlying lung diseases. Here we share our experience of a neonate with spontaneous pneumothorax with mild to moderate respiratory distress, who recovered completely with conservative management with ...
Astle Valerie V Department of Neonatology , Centenary Hospital for Women and Children , Canberra , Australia - - 2014
Abstract Objective: Pulmonary function abnormalities and hospital re-admissions in survivors of neonatal lung disease remain highly prevalent. The respiratory outcomes study (RESPOS) aimed to investigate the respiratory and associated atopy outcomes in preterm infants <30 weeks gestational age (GA) and/or birth-weight (BWt) <1000 g at primary school age, and to compare ...
Pacifici Gian Maria GM Department of Translational Research and New Technologies in Medicine and Surgery, Section of Pharmacology, Medical School, University of Pisa, Pisa, Italy. Electronic address: - - 2014
Fentanyl is a synthetic opioid that is very important in anesthetic practice because of its relatively short time to peak analgesic effect and the rapid termination of action after small bolus doses. The objective of this survey is to review the clinical pharmacology of fentanyl in preterm infants. The bibliographic ...
van der Burg P S PS Department of Neonatology, Emma Children's Hospital AMC, PO Box 22660, 1100 DD, Amsterdam, The Netherlands, - - 2014
Electrical impedance tomography (EIT) is a non-invasive, radiation-free tool to monitor regional changes in ventilation. This report describes, for the first time, that unilateral atelectasis in an extremely low birth weight infant results in a loss of regional ventilation measured by EIT in the affected lung. Conclusion: EIT is currently the ...
Wambach Jennifer A JA Edward Mallinckrodt Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO, - - 2014
The American Thoracic Society (ATS) recently published a clinical practice guideline regarding the classification, evaluation, and management of childhood interstitial lung disease in infancy (chILD). As disease entities among infants with ILD are often distinct from forms seen in older children and adults, the guideline encourages an age-based classification system ...
Alicandro Gianfranco G National Institute of Statistics (ISTAT), Rome, Italy; Cystic Fibrosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, - - 2014
Survival in cystic fibrosis (CF) has progressively improved and the female-gender disadvantage first described many years ago remains controversial. To describe the mortality trend due to CF in Italy over the last decades; to verify the female-mortality disadvantage; to compare the comorbidities reported in death certificates of CF patients with ...
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