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Sunderam Saswati - - 2014
Since the first U.S. infant conceived with Assisted Reproductive Technology (ART) was born in 1981, both the use of advanced technologies to overcome infertility and the number of fertility clinics providing ART services have increased steadily in the United States. ART includes fertility treatments in which both eggs and embryos ...
Bersani Iliana I Department of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital, Rome, - - 2014
Histologic chorioamnionitis (HCA) is an intrauterine status of inflammation which may lead to the fetal inflammatory response syndrome. Inflammation is a pathogenetic mechanism also of preeclampsia, although not of microbial origin. The aim of the present pilot study was to evaluate the pattern of inflammatory cytokines in mothers and high-risk ...
Fulda Kimberly G - - 2014
BackgroundThe purpose was to examine the association between paternal race/ethnicity and very low birth weight stratified by maternal race/ethnicity.MethodsBirth data for Tarrant County, Texas 2006¿2010 were analyzed. Very low birth weight was dichotomized as yes (<1,500 g) and no (¿1,500 g). Paternal race/ethnicity was categorized as Caucasian, African American, Hispanic, other, and ...
Moraes T J TJ Physiology and Experimental Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Paediatrics, University of Toronto, Toronto, ON, - - 2014
It is hypothesised that complex interactions between genetic and environmental factors give rise to allergy and asthma in childhood. The Canadian Healthy Infant Longitudinal Development (CHILD) study was designed to explore these factors. CHILD is a longitudinal, general population birth cohort study following infants from mid-pregnancy to age 5 years. ...
Salzer Wanda L WL U.S. Army Medical Research and Materiel Command, Fort Detrick, - - 2014
Infants with acute lymphoblastic leukemia (ALL) have a poor prognosis. Intensification of therapy has resulted in fewer relapses but increased early deaths, resulting in failure to improve survival. AALL0631 is a Phase 3 study for infants (<366 days of age) with newly diagnosed ALL. Induction initially (Cohort 1) consisted of ...
König Kai K Department of Paediatrics, Mercy Hospital for Women, 163 Studley Road, Melbourne, VIC, 3084, Australia, - - 2014
To evaluate a simplified gentamicin extended-interval dosing regimen in a large cohort of preterm and term newborns, we conducted a retrospective cohort study over a 4-year period. All inborn newborns who received gentamicin for the first episode of suspected or proven sepsis were eligible. Newborns received 4 mg/kg gentamicin intravenously 24-hourly, ...
Gassas Adam A Division of Hematology/Oncology/BMT, The Hospital for Sick Children, University of Toronto, Ontario, - - 2014
It is rare for infants, who are less than 365 days old, to receive hematopoietic stem cell transplantation (HSCT). Our objective was to review the indications, survival, and late effects of infants who received HSCT. Between April 1992 and March 2010, a total of 1,363 children underwent HSCT (775 allogeneic ...
Kastenberg Zachary J ZJ Department of Surgery, Stanford University School of Medicine, Stanford, California2Center for Health Policy/Center for Primary Care and Outcomes Research, Stanford University School of Medicine, Stanford, - - 2014
There has been a significant expansion in the number of low-level and midlevel neonatal intensive care units (NICUs) in recent decades. Infants with necrotizing enterocolitis represent a high-risk subgroup of the very low-birth-weight (VLBW) (<1500 g) population that would benefit from focused regionalization. To describe the current trend toward deregionalization ...
Audu Rosemary Ajuma RA Nigerian Institute of Medical Research, Human Virology Laboratory , 6 Edmond Crescent , Off Murtala Mohammed Way, , Yaba , Lagos, Nigeria , P.M.B. 2013 , +234 8035017790 ; - - 2014
Background: Nigeria has one of the highest HIV burdens as well as mother-to-infant transmission rates in the world. A pilot program using polymerase chain reaction (PCR)-based testing of dried blood spot (DBS) specimens was implemented to enable early identification of HIV-infected infants and timely referral and linkage to care. Method: ...
Jemal Ahmedin A All authors, Surveillance and Health Services Research, American Cancer Society, Atlanta, GA. - - 2014
Although disparities in colorectal cancer (CRC) with regard to race, socioeconomic status, and geography are well documented, the extent to which these factors contribute to premature death resulting from CRC nationwide and by state is unknown. We calculated age-standardized CRC death rates for three broad educational categories as a marker ...
Medellín-Garibay Susanna E SE Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Manuel Nava # 6, Zip Code: 78210, San Luis Potosí, S.L.P. México - - 2014
The aim of this study is to characterize and validate the population pharmacokinetics of gentamicin in infants and to determine the influence of clinically relevant covariates to explain the inter- and intra-individual variability associated to this drug. Infants receiving IV gentamicin and with routine therapeutic drug monitoring were consecutively enrolled ...
Giannì M L ML Fondazione I.R.C.C.S. Ca' Granda Ospedale Maggiore Policlinico, Neonatal Intensive Care Unit, Department of Clinical Science and Community Health, University of Milan, Milan, - - 2014
Prematurity is associated with features of metabolic syndrome in young adulthood. We investigated the body composition and blood pressure of children born preterm. A longitudinal, observational study was conducted with preterm infants who had a birth weight of less than <1500g and a gestational age of less than 32 weeks. ...
Jones Anderson A School of Paediatrics and Child Health Research, University of Western Australia; Telethon Kids Institute, University of Western - - 2014
Vitamin D (25[OH]D3) status in early life has been linked to the risk of allergic disease in multiple observational studies. While immunomodulating properties are well-recognised there are few longitudinal studies of 25(OH)D3 status, immune function and allergic disease in infants. To investigate 25(OH)D3 levels at birth (cord blood [CB]) and ...
Gunes Sezgin S Ege University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Izmir, - - 2014
To investigate the relationship between plasma chitotriosidase levels, an inflammatory protein secreted mainly from macrophages, and neonatal morbidity and mortality in premature infants. Cord blood chitotriosidase levels were studied in healthy control infants [53 term (Group 1) and 26 late preterm (33-37 gestational weeks) (Group 2)] and 35 preterm infants ...
Nnamani Nwamaka Pamela NP Brigham and Women's Hospital, Boston, MA, USA - - 2014
There has been international debate on the infrequent occurrence of malignant hyperthermia in infants, where some reports state that this phenomenon does not exist in this age group; but the vast majority of studies counteract this argument. The proportion of documented cases in the infant population warrants a good review ...
Werner Klaus K Young Epilepsy, Surrey, UK; Department of Clinical Neurophysiology, Great Ormond Street Hospital for Children NHS Trust, London, UK; Neurosciences Unit, UCL Institute of Child Health, London, - - 2014
Objectives: This study investigates auditory processing in infants with West syndrome (WS) using event-related potentials (ERPs). Methods: ERPs were measured in 25 infants with mainly symptomatic WS (age range 3-14 months) and 26 healthy term infants (age range 3-14 months) using an auditory novelty oddball paradigm. The ERP recordings were ...
Colak A A Department of Clinical Biochemistry, Tepecik Teaching and Research Hospital, Izmir, Turkey - - - 2014
Calcium supplementation during pregnancy was suggested to affect fetal growth. We aimed to investigate the association between calcium and phosphorus in cord blood and birth size parameters in term infants. The study included 70 pregnant women and their neonates. Birth weight, birth length and head circumference of the neonates were ...
Ibrahim Abdallah A School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana, - - 2014
This research determined the levels and odds ratios for low birth weight (LBW) infants delivered under the National Health Insurance Scheme (NHIS) compared to LBW infants delivered under the previous "Cash and Carry" system in Northern Ghana. Birth records of infants delivered before and after implementation of the NHIS in ...
Gad GhadaI G Departments - - 2014
Abstract Objective: to evaluate the diagnostic value of antimicrobial peptide(Cathelicidin), LL-37,in congenital pneumonia and its relation to 25 hydroxycholecalciferol [(25 OH)D] status. Methods: The study included 30 neonates with congenital pneumoniaandculture proven sepsis admitted to neonatal intensive care unit of Ain Shams Universityand 30 healthy neonates as control group.All neonates ...
Magalhães Mauricio M Division of Neonatology, Department of Pediatrics, Santa Casa de São Paulo, São Paulo, - - 2014
Neonatal hypoxic-ischemic encephalopathy is associated with high morbidity and mortality. Studies have shown that therapeutic hypothermia decreases neurological sequelae and death. Our aim was therefore to report on a three-year experience of therapeutic hypothermia among asphyxiated newborns. Retrospective study, conducted in a university hospital. Thirty-five patients with perinatal asphyxia undergoing ...
Harrison Tondi M TM Principal Investigator, Assistant Professor, Center for Cardiovascular & Pulmonary Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, JW4989, Columbus, OH, 43205; College of Medicine, The Ohio State University, Columbus, - - 2014
The quality of maternal-infant interaction is a critical factor in the development of infants' autonomic function and social engagement skills. In this secondary data analysis, relationships among infant and maternal affect and behavior and quality of dyadic interaction, as measured by the Parent-Child Early Relational Assessment, and infant autonomic function, ...
Keating Elizabeth M - - 2014
Background: Beriberi is endemic in South-east Asia. Diagnosis is based on clinical findings, but correlation of clinical features with blood thiamine concentrations is uncertain. Objectives: To investigate in tachypnoeic Cambodian infants the correlation between whole blood thiamine diphosphate (TDP) concentrations, clinical findings and blood TDP levels after therapy. Methods: Infants ...
Wright Karen D KD Division of Neuro-oncology, Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 260, Memphis, TN, 38105, USA, - - 2014
High-dose methotrexate (HD-MTX) has been used to treat children with central nervous system tumors. Accumulation of MTX within pleural, peritoneal, or cardiac effusions has led to delayed excretion and increased risk of systemic toxicity. This retrospective study analyzed the association of intracranial post-resection fluid collections with MTX plasma disposition in ...
Scalais Emmanuel E Division of Pediatric Neurology, Department of Pediatrics, Centre Hospitalier de Luxembourg, Luxembourg City, - - 2014
In neonates, very long chain acyl-CoA dehydrogenase (VLCAD) deficiency is often characterized by cardiomyopathy, hepatic encephalopathy, or severe hypoketotic hypoglycemia, or a combination thereof. The purpose of this study was to further elucidate a familial VLCAD deficiency in three patients, two of whom died in the neonatal period. We report ...
Iskander Iman I Departments of Pediatrics, - - 2014
Bilirubin/albumin ratio (B/A) may provide a better estimate of free bilirubin than total serum bilirubin (TSB), thus improving identification of newborns at risk for bilirubin encephalopathy. The objective of the study was to identify thresholds and compare specificities of TSB and B/A in detecting patients with acute and posttreatment auditory ...
Qubty William F WF Division of Child Neurology, Mayo Clinic, Rochester, - - 2014
The clinical characteristics of obstructive sleep apnea (OSA) in infants have been insufficiently characterized. Our aim was to describe identifiable comorbidities in infants with obstructive sleep apnea, which may assist in recognizing these patients earlier in their disease course and help improve management. This was a single-center, retrospective study involving ...
Mansour Fatima F Surgery Unit, UCL Institute of Child Health and Great Ormond Street Hospital for Children, 30 Guilford Street, London, WC1N 1EH, - - 2014
Sodium is thought to be critical to growth. Infants who have an ileostomy may suffer from growth faltering, as sodium losses from stomas may be excessive. Urinary sodium measurements may indicate which patients could benefit from sodium supplementation; however, there is no consensus on what level of urinary sodium should ...
Longardt A C AC Department of Neonatology, Charité University Medical Center, Berlin, - - 2014
Background/Objectives:Preterm infants have low vitamin A stores at birth, and parenteral administration of high-dose vitamin A reduces pulmonary morbidity. The aim was to characterize vitamin A transport and status.Subjects/Methods:Prospective study of 69 preterm infants (median birth weight 995 g, gestational age 28 weeks), in which 51 received 5000 IU vitamin A three ...
Garland J S JS Department of Pediatrics, Wheaton Franciscan Healthcare-St Joseph Hospital, Milwaukee, Wisconsin, - - 2014
To determine the frequency of tracheal pepsin in ventilated neonates and whether the angle of head elevation was associated with tracheal pepsin. Serial trachael samples (day 3, 7, 14, 21, 28 days of ventilation) were obtained from intubated, ventilated very low birth weight infants. Presence of tracheal pepsin was determined ...
Abdelmogheth Anas-Alwogud A AA Departments of Child Health, Sultan Qaboos University Hospital, Muscat, - - 2014
The aim of this study was to describe the pattern of viral infections in infants and children admitted to the Paediatric Intensive Care Unit (PICU) at Sultan Qaboos University Hospital (SQUH) in Muscat, Oman. A retrospective review of patient records was carried out on all patients admitted to the PICU ...
Anderssen Sven-Harald SH Department of Pediatrics, Sykehuset Østfold, Fredrikstad, - - 2014
This study aimed to evaluate the reproducibility of macronutrient measurements of domestic pooled human milk from mothers with preterm infants and to see how the results affected human milk fortifications. We asked 28 new mothers to express their breast milk for 24 hours on two consecutive days and repeat the ...
Casas Maribel M Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain. Electronic address: - - 2014
Low-level exposure to polychlorinated biphenyl-153 (PCB-153) and dichlorodiphenyldichloroethylene (p-p'-DDE) can impair fetal growth; however, the exposure-response relationship and effect modifiers of such association are not well established. This study is an extension of an earlier European meta-analysis. Our aim was to explore exposure-response relationship between PCB-153 and p-p'-DDE and birth ...
Abbasoglu Aslihan A Division of Neonatology, Department of Pediatrics, Baskent University Faculty of Medicine, Ankara, Turkey. Electronic address: - - 2014
Elevated serum levels of neuron-specific enolase (NSE) was initially assumed to be specific to neuronal tumors (particularly neuroblastoma), but is now known to accompany nontumoral conditions and tumors other than neuroblastomas. There is a need to establish normal ranges for NSE, especially in early infancy. The aims of this study ...
Gaensbauer James T JT Departments of Pediatrics Center for Global Health, Colorado School of Public Health, Aurora, USA - - 2014
To determine whether immune function is impaired among HIV-exposed but uninfected (HEU) infants born to HIV-infected mothers and to identify potential vulnerabilities to vaccine preventable infection, we characterized mother-to-infant placental transfer of Haemophilus influenzae type b-specific IgG (Hib-IgG), and levels and avidity after vaccination in Ugandan HEU infants and in ...
Reed Susan G SG Medical University of South Carolina , Charleston, South - - 2014
Abstract The purpose of this study was to investigate infant oral mutans streptococci (MS) by feeding method and by the mother's oral MS status. For this cross-sectional data collection, full-term infants at 4-6 weeks of age and their mothers were tested for oral MS using the Dentocult(®) SM chairside test ...
Zakaria Dala D Division of Pediatric Cardiology, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, - - 2014
Right ventricular (RV) function is reduced in infants with pulmonary hypertension (PH) but echocardiographic assessment can be challenging. We sought to determine the role of tricuspid annular plane systolic excursion (TAPSE) in infants with PH and compared it with other markers such as tricuspid annular S' and RV fractional area ...
Hesla Helena Marell HM Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, - - 2014
An anthroposophic lifestyle, which has been associated with reduced allergy risk in children, has several characteristics that could influence gut microbiota. This study aimed to investigate the impact of anthroposophic lifestyle as well as specific early life exposures, on the gut microbiota. In total, 665 stool samples from 128 mother-child ...
Stein Michal M Wolfson Medical Center, Holon, Israel The Sackler School of Medicine, Tel Aviv University, Tel Aviv, - - 2014
In this prospective study, we examined the usefulness of C-reactive protein (CRP), soluble triggering receptor expressed on myeloid cells (s-TREM-1), and procalcitonin (PCT), in identifying serious bacterial infection (SBI) among neonates. Infants younger than 3 months with suspected SBI were included and serum concentrations of CRP, PCT, and s-TREM-1 were ...
Hulzebos Christian V CV Department of Pediatrics, Beatrix Children׳s Hospital, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands. Electronic address: - - 2014
Treatment for unconjugated hyperbilirubinemia is predominantly based on one parameter, i.e., total serum bilirubin (TSB) levels. Yet, overt kernicterus has been reported in preterm infants at relatively low TSB levels, and it has been repeatedly shown that free unconjugated bilirubin (freeUCB) levels, or bilirubin/albumin (B/A) ratios for that matter, are ...
Bharathi B B Division of Neonatology, Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, 605 006, - - 2014
To identify biomarkers for neuronal injury and outcome in perinatal asphyxia. This prospective cohort study was done in authors' level III NICU involving 80 neonates - 40 babies with perinatal asphyxia and 40 weight and gender matched normal neonates. Levels of cytokines IL-6, IL -1β, IL-2 and TNF -α in ...
Chen Wen W Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, - - 2014
The effects of long-term excessive maternal iodine intake on neonatal thyroid function is less known. This study aimed to assess the effects of maternal excessive iodine intake from drinking water on thyroid functions of both mothers and their neonates. This observational study was performed in high iodine (HI) areas and ...
Hibbs A M AM 1] Department of Pediatrics, Case Western Reserve School of Medicine, Cleveland, OH, USA [2] Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, OH, - - 2014
Objective:We aimed to determine whether vitamin D exposure, as estimated by use of multivitamins, is positively or negatively associated with recurrent wheezing in infants born preterm.Study Design:This prospective cohort study enrolled 300 infants, born at 28(0/7) to 34(6/7) weeks gestational age, and conducted follow-up at 3-, 6-, 9- and 12-month ...
Ozguven Ali Aykan AA Department of Pediatric Hematology and Oncology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, - - 2014
To determine outcome of neuroblastoma (NBL) in children under 18 mo of age who had been treated with national protocols. The characteristics and treatment outcomes of 27 children were evaluated retrospectively. The event-free survival (EFS) at 60 and 108 mo were 84.7 % ± 7.7 and 72.6 % ± 7.7, respectively. The overall survival (OS) was 91.7 % ± 8 at ...
Zionts Lewis E LE Orthopaedic Institute for Children, 403 West Adams Boulevard, Los Angeles, CA 90007. E-mail address: - - 2014
The Ponseti method is an established approach to treating idiopathic clubfoot in infants. The method involves a period of cast immobilization and postcorrective bracing that potentially interferes with normal movements of the lower extremities. In the present study, we investigated the age at which infants who had idiopathic clubfoot treated ...
Edmunds Suzanne M SM From the Departments of Anesthesiology and Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, - - 2014
Alcohol ingestion in the pediatric patient can be life threatening. Younger patients consume larger volumes per body weight with accidental ingestions, and children have more serious adverse effects at lower blood alcohol levels. Complications of alcohol poisoning can include hypothermia, hypoglycemia, seizures, coma, and death. We present the course of ...
Shim So-Yeon SY Division of Neonatology, Ewha Womans University, School of Medicine, Seoul, - - 2014
Background: Even preterm infants with normal magnetic resonance imaging (MRI) results are at greater risk for neuromotor dysfunction. Objectives: Our aim was to compare serial diffusion tensor imaging (DTI) data from preterm infants without apparent brain abnormalities on magnetic resonance imaging with those from term controls and to investigate the ...
Bansal Seema S 1Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. 2Children's National Medical Center, Washington, - - 2014
To determine the prevalence of acute symptomatic seizures in infants with supratentorial intracranial hemorrhage, to identify potential risk factors, and to determine the effect of acute seizures on long-term morbidity and mortality. Children less than 24 months with intracranial hemorrhage were identified from a neurocritical care database. All patients who ...
Friedman Eleanor E EE Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of - - 2014
Dengue is a mosquito-borne disease that is common in many tropical and subtropical areas. Dengue infections can occur at any age and time in the lifespan, including during pregnancy. Few large scale studies have been conducted to determine the risk of preterm birth (PTB) and low birthweight (LBW) for infants ...
Koontz M B MB Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, - - 2014
Rapid weight gain in infancy has been established as a risk factor for the development of later obesity. We aimed to investigate the role of changes in infant body composition (assessed via total body electrical conductivity) on the development of overweight/obesity in mid-childhood. Fifty-three term infants were evaluated at birth, ...
Eckhardt Cara L CL School of Community Health, Portland State University, Portland , USA - - 2014
Abstract Background: Maternal vitamin D status in pregnancy is linked to foetal growth and may impact infant growth. Aim: This study examined the association between maternal vitamin D status and infant anthropometry. Subjects and methods: Data came from n = 2473 mother-child pairs from the 12-site US Collaborative Perinatal Project (1959-1965). Maternal ...
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