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Shah Nidhi Agrawal NA Lucile Packard Children's Hospital Stanford, Palo Alto, California, - - 2014
Amplitude-integrated electroencephalography (aEEG) is a method for continuous monitoring of brain activity that is increasingly used in the neonatal intensive care unit. In its simplest form, aEEG is a processed single-channel electroencephalogram that is filtered and time-compressed. Current evidence demonstrates that aEEG is useful to monitor cerebral background activity, diagnose ...
Allegaert Karel K University Hospitals Leuven, Neonatal Intensive Care Unit , Herestraat 49, 3000 Leuven , Belgium +32 16 343850 ; +32 16 343209 ; - - 2014
Introduction: Extensive within-population variability is the essence of neonatal pharmacology. Despite this, infants remain one of the last therapeutic orphans. Together with additional legal initiatives, tailoring of already available tools (modeling, covariates, pharmacovigilance) may significantly improve pharmacotherapy in infants. Areas covered: Modeling approaches that hold the promise to improve pharmacotherapy ...
Wu Tai T Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, - - 2014
To explore the imaging findings of neonatal infants infected with enteroviruses. A retrospective study was conducted on 12 patients who were diagnosed with encephalitis caused by enterovirus. Clinical presentation, cranial ultrasonography (cUS), magnetic resonance imaging (MRI) findings and neurodevelopment outcome of 12 cases were analysed. Twelve infants, with a gestational ...
Ecochard-Dugelay Emmanuelle - - 2014
Acute viral respiratory exacerbation is one of the most common conditions encountered in a paediatric emergency department (PED) during winter months. We aimed at defining clinical predictors of chest radiography prescription and radiographic abnormalities, among infants with bronchiolitis in a paediatric emergency department. We conducted a prospective cohort study of ...
Taşkınlar Hakan H Department of Pediatric Surgery, School of Medicine, Mersin University, Mersin, - - 2014
Although necrotizing enterocolitis (NEC) is a frequently encountered entity in premature infants in the neonatal intensive care unit, intussusception is extremely rare. Abdominal distension, bilious/non-bilious gastric residuals and bloody stool are the common clinical findings of both entities. Here we present three cases of intussusception misdiagnosed as NEC, two of ...
Edmonds Joyce K - - 2014
Cesarean birth is the most common surgical procedure in the United States and is associated with increased morbidity and mortality when compared to vaginal birth. Of the more than 4 million births a year, one in three is now a cesarean. A better understanding of the clinical indications contributing to ...
Higgins M M Obstetrics and Gynaecology, University College Dublin, National Maternity Hospital, Dublin, - - 2014
: The aim of this study was to review the clinical outcomes of congenital haemangiomas and lymphangiomas in our unit. Retrospective cohort study. Between January 2004 and March 2013, over 67,000 infants delivered in Mount Sinai, of which 45 had a diagnosis of haemangioma (n = 23) or lymphangioma (n ...
Neville G G National Maternity Hospital, Holles Street, Dublin 2, - - 2014
: Accurate identification of high risk groups and focused efforts at reducing their risk may be the most effective method currently available of reducing the incidence and associated squeale of preterm birth. A preterm surveillance clinic was established in March 2012 to provide expert management of those at risk of ...
Palanisami B B St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, - - 2014
Asymptomatic cardiac murmurs are commonly detected on newborn examination. These babies are frequently referred to paediatric cardiology services. To reduce waiting time for evaluation of these neonates, a neonatologist run echocardiography clinic was set up. To analyse the cardiac disease burden and time to diagnosis of neonates referred to neonatal ...
Fairclough G G Birmingham Women's Hospital NHS Foundation Trust, Birmingham, - - 2014
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis in infants. Palivizumab is an anti-RSV monoclonal antibody providing passive immunity against RSV. The Joint Committee for Vaccination and Immunisation (JCVI) have produced guidelines for high-risk babies that fulfil the criteria for receiving Palivizumab. Service evaluation of the dedicated Paviluzumab ...
Battersby C C Imperial College London, London, - - 2014
Lack of a universal case-definition hinders (NEC) surveillance and clinical trials. Bell's staging, although widely used, was devised to guide surgical management after diagnosis(1). We aimed to develop an evidence-based NEC case-definition. We used the National Neonatal Research Database, that holds data extracted from the electronic records of babies admitted ...
Corcoran P P National Perinatal Epidemiology Centre, University College Cork, Cork, - - 2014
Perinatal mortality has decreased in high-resource countries but cause of death, especially for stillbirths, is often unexplained. The Irish National Perinatal Epidemiology Centre (NPEC) established a national clinical audit on perinatal deaths to better identify causes of death and associated risk factors. After piloting the NPEC Perinatal Death Notification Form ...
Carbajal R R Trousseau Hospital, Paris, France Inserm U953, Paris, France UPMC, Paris, - - 2014
Pain and stress induced by mechanical ventilation, invasive procedures, or painful diseases supports the use of sedation/analgesia (S/A) in newborns admitted to Neonatal Units (NNUs). To date, these practices have not been studied on a large scale. To determine current clinical practices regarding the use of S/A drugs in NNUs ...
Seager E E Birmingham Womens Hospital, Birmingham, - - 2014
Lumbar puncture (LP) is usually performed when there is a clinical suspicion of meningitis in babies with suspected sepsis. NICE recently published their guidelines on 'antibiotics for early-onset neonatal infections' with guidance on when LPs should be considered. To audit the number of LPs carried out in term babies (>37+0 ...
Rasiah Sv S South West Midlands Newborn Network, Birmingham, UK Birmingham Women's Hospital NHS Foundation Trust, Birmingham, - - 2014
One of the aims of managed newborn clinical networks is to monitor and report on their neonatal mortality as an outcome measures of improvements in quality of care. The South West Midlands Newborn Network (SWMNN) was established in 2004. Badger electronic patient database has been used since 2009 across all ...
Roberts Jessica K JK Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, Salt Lake City, UT, 84108, - - 2014
Antimicrobials and antivirals are widely used in young infants and neonates. These patients have historically been largely excluded from clinical trials and, as a consequence, the pharmacokinetics and pharmacodynamics of commonly used antibacterials, antifungals, and antivirals are incompletely understood in this population. This review summarizes the current literature specific to ...
- - 2014
Data from large randomized clinical trials indicate that therapeutic hypothermia, using either selective head cooling or systemic cooling, is an effective therapy for neonatal encephalopathy. Infants selected for cooling must meet the criteria outlined in published clinical trials. The implementation of cooling needs to be performed at centers that have ...
Autmizguine J - - 2014
Infants are therapeutic orphans. Many drugs used in infantsare used "off-label", increasing the risk of drug toxicity and suboptimal efficacy in this vulnerable population. This knowledge gap in clinical pharmacology is partly attributed to challenges associatedwith conducting clinical trials in infants. Consequently, there is a need for novel and efficient ...
Sola Augusto A President Ibero American Society of Neonatology - - 2014
Oxygen is a neonatal health hazard that should be avoided in clinical practice. In this review, an international team of neonatologists and nurses assessed oxygen saturation (SpO2 ) targeting in preterm infants and evaluated the potential weaknesses of randomised clinical trials. Conclusions SpO2 of 85-89% can increase mortality and 91-95% ...
Shankaran Seetha S Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, 48201, USA, - - 2014
This article reviews the pathophysiology of hypoxic-ischemic brain injury, and the impact of hypothermia as neuroprotection in the clinical setting. The results of trials performed in well resourced and mid and low resourced countries is presented. Infant and childhood outcome following hypothermia is provided. Biomarkers of outcome that are clinical, ...
Honsel Maik M Paediatric and Neonatal Intensive Care Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, - - 2014
Neuromuscular blocking agents (NMBA) are used in a range of critical illnesses in neonates and infants, despite a lack of guidelines and professional standards. This study reviewed the current evidence base and ascertained UK practice regarding the continuous use of these agents in this age range. We reviewed the literature ...
Small Susan A SA School of Audiology & Speech Sciences, University of British Columbia , Vancouver , - - 2014
Objective: To determine whether ipsilateral/contralateral asymmetries in the bone-conduction (BC) ASSR are robust enough in infants to be used clinically to isolate the test ear. Design: Retrospective investigation of three two-channel BC ASSR datasets. Subjects: Forty-eight adults (mean age 26.7 years), 49 infants (mean age 29.6 weeks). Methods: BC ASSR ...
Barnhart Kurt T KT Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: - - 2014
Well-designed and -conducted clinical trials are needed to further advance the field for reproductive medicine. However, current reporting of outcomes of trials is ambiguous and disparate. In this review it is offered that the preferred outcome for clinical trials in reproductive medicine should be live birth. Multiple births should be ...
Van Noolen L L Département de Biochimie, Toxicologie et Pharmacologie, Institut de Biologie et Pathologie, CHU Grenoble, Grenoble, - - 2014
Vitamin B12 deficiency can lead to serious haematological and neurological signs in infants. The reported clinical cases of vitamin B12 deficiency were found in exclusively breast-fed infants whose asymptomatic mothers were diagnosed later with pernicious anaemia. For the infants, the diagnosis required urinary methylmalonic acid quantification (grossly elevated in these ...
Finkel Richard S RS Divisions of Neurology, Nemours Children's Hospital, Orlando, - - 2014
To determine the feasibility and safety of respiratory muscle function testing in weak infants with a progressive neuromuscular disorder. Respiratory insufficiency is the major cause of morbidity and mortality in infants with spinal muscular atrophy type I (SMA-I). Tests of respiratory muscle strength, endurance, and breathing patterns can be performed ...
Tidmarsh G F GF Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, - - 2014
Hemolytic disease in newborns can result from a number of conditions, which can place such infants at an increased risk for the development of severe hyperbilirubinemia. Because the catabolism of heme produces equimolar amounts of carbon monoxide (CO) and bilirubin, measurements of end-tidal breath CO (corrected for ambient CO) or ...
Patel Shyama D SD *Department of Pediatrics/Newborn Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10025, - - 2014
Neonatal encephalopathy resulting from HI (hypoxia-ischaemia) continues to be a significant cause of mortality and morbidity in infants and children, affecting 1-2/1000 live term births and up to 60% of pre-term births. In order to understand the pathophysiology of this insult, as well as design therapeutic interventions, it is important ...
Erfanianahmadpoor Mahmood M Anatomy Department, Mashhad Medical Branch, Islamic Azad University, Mashhad, - - 2014
To assess specific anti-cytomegalovirus (CMV) antibodies, clinical status, and demographic data in pregnant women and their infants in northeast Iran. This cross-sectional study was conducted on 225 systematic randomly selected-pregnant women and their newborns attending public hospitals in Mashhad, Iran between December 2007 and January 2008. Two specialists performed clinical ...
Shemie Sam D SD Canadian Blood Services and Division of Critical Care, Montreal Children's Hospital, McGill University Health Centre, 2300 Tupper Street room C-806, Montreal, QC, H3H 1P3, Canada, - - 2014
This report summarizes the results of the first phase in the development of international guidelines for death determination, focusing on the biology of death and the dying process, developed by an invitational forum of international content experts and representatives of a number of professional societies. Precise terminology was developed in ...
Avhad Rajendra R Assistant Professor, Department of Prosthetic Dentistry, Government Dental College and Hospital, Mumbai, Maharashtra, - - 2014
A cleft lip and palate consists of fissures of the upper lip and/or palate, and is the most commonly seen orofacial anomaly that involves the middle third of the face. Early treatment of patients with a cleft lip and palate is important because of esthetic, functional, and psychological concerns. Nasoalveolar ...
Zanelli S S Department of Pediatrics, University of Virginia, Charlottesville, VA, USA. Electronic address: - - 2014
Hypoxemic events are common in sick preterm and term infants and represent the most common cause of seizures in the newborn period. Neonatal seizures often lack clinical correlates and are only recognized by electroencephalogram (EEG). The mechanisms leading from a hypoxic/ischemic insult to acute seizures in neonates remain poorly understood. ...
Falkenstein-Hagander Kathy K Department of Pediatrics, Skåne University Hospital Malmö, Lund University, Sweden; Department of Anesthesiology, Children's Hospital Boston, Boston, MA, - - 2014
To determine the prevalence of various types of viruses in infants hospitalised due to respiratory distress, compare molecular diagnostic tests and evaluate symptom severity METHODS: All 136 nasopharyngeal aspirates from infants hospitalised for respiratory distress over a nine-month period were analysed for virus type by in-house respiratory syncytial virus (RSV) ...
Meadows John Thomas JT Jr Division of Neonatology, University of Tennessee Medical Center, Knoxville, Tennessee. Electronic address: - - 2014
Rachischisis totalis is a rare open neural tube defect often associated with lethal acrania. When acrania is not present, mortality remains high and morbidity for survivors is extreme. We describe is a term newborn with in-utero diagnosed rachischisis totalis without acrania and Chiari II malformation with subsequent hydrocephalus. At birth, ...
Carcillo Joseph A JA Department of Pediatrics and Critical Care Medicine, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: - - 2014
This is a synopsis of the term newborn and infant portion of the 2007 document (Brierley et al., Crit Care Med 2009;37(2):666-88) which examined and graded new studies performed to test the utility and efficacy of the 2002 recommendations. This 2007 document examined and graded relevant new treatment and outcome ...
Thorley Virginia - - 2014
In 20th century Australia, free well-baby clinics were run by maternal and child health nurses, although the funding and organisational structure varied from state to state. It was assumed that women who attended followed the advice assiduously; yet attendance did not necessarily equate to practice. In Queensland, the state government's ...
Canty Kristi M KM From the Section of Dermatology, Children's Mercy Hospitals and Clinics, and the Department of Radiology, University of Missouri-Kansas City School of Medicine, Kansas City, - - 2014
The objectives of the study were to determine the rate of hepatic hemangiomas in infants with cutaneous infantile hemangiomas that were screened by abdominal ultrasound; identify morphological subtypes and number of cutaneous infantile hemangiomas that are likely to suggest the presence of hepatic hemangiomas; and identify clinical history, physical findings, ...
Nimbalkar Somashekhar Marutirao SM Professor, Department of Paediatrics, Pramukhswami Medical College , Karamsad, Gujarat, India - - 2014
Tracheal Agenesis (TA) presents with respiratory distress at birth. Diagnosis requires recognition of clinical signs in newborns like failure of endotracheal intubation, respiratory distress with absent air entry over both side of chest and inaudible cry. We describe a TA Floyd Type I with a Tracheo-Oesophageal Fistula (TOF) without other ...
Richter Linda L Human Sciences Research Council, Durban, KwaZulu-Natal, South - - 2014
Throughout Africa, Peer Mentors who are women living with HIV (WLH) are supporting pregnant WLH at antenatal and primary healthcare clinics (McColl in BMJ 344:e1590, 2012). We evaluate a program using this intervention strategy at 1.5 months post-birth. In a cluster randomized controlled trial in KwaZulu-Natal, South Africa, eight clinics were ...
Zhou Wei-Qin WQ Department of Pediatrics, BaYi Children's Hospital Affiliated to the Clinical Medical College of the General Hospital of Beijing Military Region, Southern Medical University, Beijing, - - 2014
Information about clinical outcomes of very preterm (VPT) infants in tertiary neonatal intensive care unit (NICU) setting is scant in China. This study aimed to investigate the mortality and morbidity of VPT infants admitted to BaYi Children's Hospital, which serves as a NICU referral center for the city of Beijing, ...
Rotheram-Borus Mary Jane MJ Global Center for Children and Families, University of California, Los Angeles, California, United States of - - 2014
We evaluate the effect of clinic-based support by HIV-positive Peer Mentors, in addition to standard clinic care, on maternal and infant well-being among Women Living with HIV (WLH) from pregnancy through the infant's first year of life. In a cluster randomized controlled trial in KwaZulu-Natal, South Africa, eight clinics were ...
Tsai Ming-Horng MH Division of Neonatology and Pediatric Hematology/Oncology, Department of Pediatrics, Chang Gung Memorial Hospital, Yunlin, Taiwan ; College of Medicine, Chang Gung University, Taoyuan, Taiwan ; Chang Gung University of Science and Technology, Chiayi, - - 2014
Polymicrobial bloodstream infections (PBSIs) have been associated with complex underlying medical conditions and a high incidence of specific microorganisms in several settings, but the relevant data are scarce in neonates. Positive blood cultures from January 2004 to December 2011 in the neonatal intensive care unit (NICU) of Chang Gung Memorial ...
Sullivan Brynne A BA Department of Pediatrics, University of Virginia Health System, Charlottesville, - - 2014
To identify clinical conditions associated with a large increase (spike) in the heart rate characteristics index in very low birth weight (VLBW) infants. Retrospective medical record review within a day of all large heart rate characteristics index spikes (increase of ≥3 from the previous 5-day average) in VLBW infants at ...
Fernandes Ricardo M RM Department of Pediatrics, Santa Maria Hospital, Lisbon Academic Medical Centre, Portugal2Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, - - 2014
CLINICAL QUESTION Are glucocorticoids, alone or combined with bronchodilators, associated with reduced admission rates, length of stay, or improvements in clinical severity scores without increased adverse effects in infants and young children with acute viral bronchiolitis? BOTTOM LINE There is no consistent clinically relevant association of single therapy with systemic ...
Maastrup Ragnhild R Knowledge Centre for Breastfeeding Infants with Special Needs at Department of Neonatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark ; Department of Health Sciences, Faculty of Medicine, Lund University, Lund, Sweden ; Danish National Panel of Experts on Breastfeeding Infants with Special - - 2014
Evidence-based knowledge of how to guide the mothers of preterm infants in breastfeeding establishment is contradictive or sparse. The aim was to investigate the associations between pre-specified clinical practices for facilitating breastfeeding, and exclusive breastfeeding at discharge as well as adequate duration thereof. A prospective survey based on questionnaires was ...
Ji Jun J State Key Laboratory of Industrial Control Technology, Institute of Industrial Process Control, Zhejiang University, Hangzhou, Zhejiang, China ; Department of Surgery, Stanford University, Stanford, California, United States of - - 2014
Necrotizing enterocolitis (NEC) is a major source of neonatal morbidity and mortality. Since there is no specific diagnostic test or risk of progression model available for NEC, the diagnosis and outcome prediction of NEC is made on clinical grounds. The objective in this study was to develop and validate new ...
Yilmaz Osman O Department of Pediatric Cardiology, District Training and Research Hospital, Erzurum, 25070, - - 2014
Superior vena cava syndrome (SVCS) is rare in infants. Non-Hodgkin lymphoma is the most common cause of SVCS in children. Swelling in the face and neck are the most common clinical symptoms associated with this syndrome. However, these clinical findings are also observed in allergic diseases, which therefore often leads ...
Markham Kara B KB Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, The Ohio State University, Columbus, - - 2014
To evaluate whether progestin prophylaxis influenced the odds of recurrent spontaneous preterm birth among pregnant women with a previous preterm birth. A retrospective cohort study was performed evaluating outcomes of pregnant women with one or more previous preterm births who received prenatal care in a single academic prematurity clinic. Care ...
Cuna Alain A Department of Pediatrics, Winthrop University Hospital , Mineola, NY , - - 2014
Background: Although histologic chorioamnionitis (HCA) is known to be associated with poor outcomes in preterm infants, its clinical significance among term infants is not clearly known. Objectives: To investigate the utility of HCA in determining early onset clinical sepsis (EOCS) among term newborns. Methods: The incidence of HCA and EOCS ...
Poddighe Dimitri D Department of Pediatrics, Ospedale di Circolo di Melegnano, Vizzolo Predabissi, - - 2014
Unconjugated hyperbilirubinaemia is a common finding in newborns. When it is exaggerated, it is usually investigated in order to exclude several diseases, such as newborn's haemolytic diseases, infections or hypothyroidism. Breast milk jaundice is a form of neonatal jaundice related to breast feeding and it is not usually associated with ...
García-Muñoz Rodrigo Fermín F Complejo Hospitalario Universitario Insular Materno-Infantil de Las Palmas, Las Palmas de Gran Canaria, - - 2014
Background: Chorioamnionitis is a recognized risk factor of preterm delivery; however, controversy still persists concerning the relationship between maternal inflammation and neonatal morbidity and mortality. Objective: To determine the incidence of clinical chorioamnionitis and its relationship to morbidity and mortality among very-low-birth-weight (VLBW) infants. Methods: This was a retrospective analysis ...
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